Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	D-glucose transmembrane transporter activity	SLC2A14 MFSD4A SLC2A1	1.39e-04	25	81	3	GO:0055056
GeneOntologyMolecularFunction	hexose transmembrane transporter activity	SLC2A14 MFSD4A SLC2A1	1.39e-04	25	81	3	GO:0015149
GeneOntologyMolecularFunction	monosaccharide transmembrane transporter activity	SLC2A14 MFSD4A SLC2A1	1.75e-04	27	81	3	GO:0015145
GeneOntologyMolecularFunction	sugar transmembrane transporter activity	SLC2A14 MFSD4A SLC2A1	2.18e-04	29	81	3	GO:0051119
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	TYRO3 OR2A7 OPN4 OR6B3 PTPRH OR2A4 GPR75 RXFP2 INSRR OR2G2 GPR52 OSMR MERTK OR6B2 CHRM3	3.16e-04	1353	81	15	GO:0004888
GeneOntologyMolecularFunction	dehydroascorbic acid transmembrane transporter activity	SLC2A14 SLC2A1	4.48e-04	8	81	2	GO:0033300
GeneOntologyMolecularFunction	galactoside binding	GLB1 SLC2A14	5.74e-04	9	81	2	GO:0016936
GeneOntologyMolecularFunction	carbohydrate transmembrane transporter activity	SLC2A14 MFSD4A SLC2A1	6.59e-04	42	81	3	GO:0015144
GeneOntologyMolecularFunction	exopeptidase activity	TPP2 ACE2 ERMP1 XPNPEP2	1.05e-03	110	81	4	GO:0008238
GeneOntologyMolecularFunction	G protein-coupled photoreceptor activity	OPN4 GPR52	1.65e-03	15	81	2	GO:0008020
GeneOntologyMolecularFunction	odorant binding	OR2A7 OR6B3 OR2A4 OR6B2	1.78e-03	127	81	4	GO:0005549
GeneOntologyCellularComponent	tenascin complex	TNC TNR TNXB	2.24e-07	4	81	3	GO:0090733
GeneOntologyCellularComponent	protein complex involved in cell-matrix adhesion	TNC TNR TNXB	3.66e-05	17	81	3	GO:0098637
GeneOntologyCellularComponent	protein complex involved in cell adhesion	TNC TNR ITGB4 TNXB	8.10e-05	59	81	4	GO:0098636
GeneOntologyCellularComponent	host cell part	GBP7 GBP3	2.20e-04	6	81	2	GO:0033643
GeneOntologyCellularComponent	host intracellular part	GBP7 GBP3	2.20e-04	6	81	2	GO:0033646
GeneOntologyCellularComponent	host cell cytoplasm part	GBP7 GBP3	2.20e-04	6	81	2	GO:0033655
GeneOntologyCellularComponent	symbiont-containing vacuole	GBP7 GBP3	2.20e-04	6	81	2	GO:0020003
GeneOntologyCellularComponent	symbiont-containing vacuole membrane	GBP7 GBP3	2.20e-04	6	81	2	GO:0020005
GeneOntologyCellularComponent	host intracellular region	GBP7 GBP3	2.20e-04	6	81	2	GO:0043656
GeneOntologyCellularComponent	host cell cytoplasm	GBP7 GBP3	2.20e-04	6	81	2	GO:0030430
GeneOntologyCellularComponent	Flemming body	OR2A7 OR2A4 BIRC6	3.65e-04	36	81	3	GO:0090543
GeneOntologyCellularComponent	perisynaptic extracellular matrix	TNC TNR	7.97e-04	11	81	2	GO:0098966
GeneOntologyCellularComponent	synapse-associated extracellular matrix	TNC TNR	1.13e-03	13	81	2	GO:0099535
GeneOntologyCellularComponent	host cellular component	GBP7 GBP3	1.51e-03	15	81	2	GO:0018995
GeneOntologyCellularComponent	mitotic spindle midzone	OR2A7 OR2A4	1.72e-03	16	81	2	GO:1990023
GeneOntologyCellularComponent	midbody	OR2A7 OR2A4 EXOC3 BIRC6 SLC2A1	1.72e-03	222	81	5	GO:0030496
GeneOntologyCellularComponent	apical plasma membrane	ACE2 SLC12A3 PTPRH KCNMA1 TMEM235 OSMR SLC2A1	2.81e-03	487	81	7	GO:0016324
Domain	fn3	TYRO3 IGFN1 SDK2 PTPRH PTPRJ TNC INSRR OSMR MERTK TNR ITGB4 TNXB SDK1	7.69e-14	162	75	13	PF00041
Domain	FN3	TYRO3 IGFN1 SDK2 PTPRH PTPRJ TNC INSRR OSMR MERTK TNR ITGB4 TNXB SDK1	4.28e-13	185	75	13	SM00060
Domain	FN3	TYRO3 IGFN1 SDK2 PTPRH PTPRJ TNC INSRR OSMR MERTK TNR ITGB4 TNXB SDK1	1.09e-12	199	75	13	PS50853
Domain	FN3_dom	TYRO3 IGFN1 SDK2 PTPRH PTPRJ TNC INSRR OSMR MERTK TNR ITGB4 TNXB SDK1	2.04e-12	209	75	13	IPR003961
Domain	Ig-like_fold	TYRO3 IGKV1-5 IGFN1 SDK2 PTPRH PTPRJ TNC INSRR OSMR MERTK TNR ITGB4 TNXB SDK1	7.08e-07	706	75	14	IPR013783
Domain	-	TYRO3 IGFN1 SDK2 PTPRJ TNC INSRR OSMR MERTK TNR ITGB4 TNXB SDK1	1.22e-05	663	75	12	2.60.40.10
Domain	EGF_extracell	TNC TNR ITGB4 TNXB	9.86e-05	60	75	4	IPR013111
Domain	EGF_2	TNC TNR ITGB4 TNXB	9.86e-05	60	75	4	PF07974
Domain	Fibrinogen_a/b/g_C_2	TNC TNR TNXB	1.18e-04	24	75	3	IPR014715
Domain	-	TNC TNR TNXB	1.18e-04	24	75	3	4.10.530.10
Domain	Fibrinogen_C	TNC TNR TNXB	1.70e-04	27	75	3	PF00147
Domain	FBG	TNC TNR TNXB	2.11e-04	29	75	3	SM00186
Domain	-	TNC TNR TNXB	2.34e-04	30	75	3	3.90.215.10
Domain	Fibrinogen_a/b/g_C_1	TNC TNR TNXB	2.34e-04	30	75	3	IPR014716
Domain	FIBRINOGEN_C_1	TNC TNR TNXB	2.84e-04	32	75	3	PS00514
Domain	Fibrinogen_a/b/g_C_dom	TNC TNR TNXB	2.84e-04	32	75	3	IPR002181
Domain	FIBRINOGEN_C_2	TNC TNR TNXB	2.84e-04	32	75	3	PS51406
Domain	GPCR_Rhodpsn_7TM	OR2A7 OPN4 OR6B3 OR2A4 GPR75 RXFP2 OR2G2 GPR52 OR6B2 CHRM3	3.34e-04	670	75	10	IPR017452
Domain	7tm_1	OR2A7 OPN4 OR6B3 OR2A4 GPR75 RXFP2 OR2G2 GPR52 OR6B2 CHRM3	3.62e-04	677	75	10	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2A7 OPN4 OR6B3 OR2A4 GPR75 RXFP2 OR2G2 GPR52 OR6B2 CHRM3	3.98e-04	685	75	10	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2A7 OPN4 OR6B3 OR2A4 GPR75 RXFP2 OR2G2 GPR52 OR6B2 CHRM3	4.26e-04	691	75	10	PS50262
Domain	GPCR_Rhodpsn	OR2A7 OPN4 OR6B3 OR2A4 GPR75 RXFP2 OR2G2 GPR52 OR6B2 CHRM3	4.31e-04	692	75	10	IPR000276
Domain	GBP_C	GBP7 GBP3	7.01e-04	10	75	2	PF02841
Domain	G_GB1_RHD3_dom	GBP7 GBP3	8.55e-04	11	75	2	IPR030386
Domain	Guanylate-bd_C	GBP7 GBP3	8.55e-04	11	75	2	IPR003191
Domain	GBP	GBP7 GBP3	8.55e-04	11	75	2	PF02263
Domain	Guanylate-bd_N	GBP7 GBP3	8.55e-04	11	75	2	IPR015894
Domain	G_GB1_RHD3	GBP7 GBP3	8.55e-04	11	75	2	PS51715
Domain	Ig_I-set	TYRO3 IGFN1 SDK2 MERTK SDK1	1.00e-03	190	75	5	IPR013098
Domain	I-set	TYRO3 IGFN1 SDK2 MERTK SDK1	1.00e-03	190	75	5	PF07679
Domain	Sugar/inositol_transpt	SLC2A14 SLC2A1	1.40e-03	14	75	2	IPR003663
Domain	L_dom-like	FBXL16 CNOT6L LRRTM4 RXFP2 INSRR LRRC58	2.04e-03	328	75	6	IPR032675
Domain	SUGAR_TRANSPORT_2	SLC2A14 SLC2A1	2.08e-03	17	75	2	PS00217
Domain	HEAT_REPEAT	UTP20 HEATR5A TANGO6	2.81e-03	70	75	3	PS50077
Domain	EGF_1	TNC TNR MUC3A ITGB4 TNXB	3.62e-03	255	75	5	PS00022
Domain	EGF-like_CS	TNC TNR MUC3A ITGB4 TNXB	4.00e-03	261	75	5	IPR013032
Domain	SUGAR_TRANSPORT_1	SLC2A14 SLC2A1	4.15e-03	24	75	2	PS00216
Domain	EGF_2	TNC TNR MUC3A ITGB4 TNXB	4.26e-03	265	75	5	PS01186
Domain	Leu-rich_rpt	FBXL16 CNOT6L LRRTM4 RXFP2 LRRC58	4.68e-03	271	75	5	IPR001611
Domain	LRR_8	CNOT6L LRRTM4 RXFP2 LRRC58	4.98e-03	171	75	4	PF13855
Domain	TyrKc	TYRO3 INSRR MERTK	5.34e-03	88	75	3	SM00219
Domain	Tyr_kinase_cat_dom	TYRO3 INSRR MERTK	5.34e-03	88	75	3	IPR020635
Domain	Leu-rich_rpt_typical-subtyp	CNOT6L LRRTM4 RXFP2 LRRC58	5.62e-03	177	75	4	IPR003591
Domain	LRR_TYP	CNOT6L LRRTM4 RXFP2 LRRC58	5.62e-03	177	75	4	SM00369
Domain	PROTEIN_KINASE_TYR	TYRO3 INSRR MERTK	7.00e-03	97	75	3	PS00109
Domain	Tyr_kinase_AS	TYRO3 INSRR MERTK	7.00e-03	97	75	3	IPR008266
Domain	Sugar_transporter_CS	SLC2A14 SLC2A1	7.30e-03	32	75	2	IPR005829
Pubmed	The tenascin gene family.	TNC TNR TNXB	1.26e-08	3	82	3	7530141
Pubmed	Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions.	TNC TNR TNXB	1.26e-08	3	82	3	7694605
Pubmed	YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis.	TNC TNR TNXB	2.74e-06	12	82	3	10101119
Pubmed	Increased Circulating and Urinary Levels of Soluble TAM Receptors in Diabetic Nephropathy.	TYRO3 MERTK	5.49e-06	2	82	2	28668213
Pubmed	Both GLUT-1 and GLUT-14 are Independent Prognostic Factors in Gastric Adenocarcinoma.	SLC2A14 SLC2A1	5.49e-06	2	82	2	26183839
Pubmed	The tenascin gene family in axon growth and guidance.	TNC TNXB	5.49e-06	2	82	2	9321695
Pubmed	Tenascins and inflammation in disorders of the nervous system.	TNC TNR	5.49e-06	2	82	2	23269478
Pubmed	Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis.	TYRO3 MERTK	5.49e-06	2	82	2	21496228
Pubmed	Tenascin-X expression in tumor cells and fibroblasts: glucocorticoids as negative regulators in fibroblasts.	TNC TNXB	5.49e-06	2	82	2	8856503
Pubmed	Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy.	SDK2 SDK1	5.49e-06	2	82	2	15213259
Pubmed	Definition of the critical domains required for homophilic targeting of mouse sidekick molecules.	SDK2 SDK1	5.49e-06	2	82	2	15703275
Pubmed	Architecture of cell-cell adhesion mediated by sidekicks.	SDK2 SDK1	5.49e-06	2	82	2	30150416
Pubmed	Potent neutralization of SARS-CoV-2 variants of concern by an antibody with an uncommon genetic signature and structural mode of spike recognition.	ACE2 IGHV2-5	5.49e-06	2	82	2	34592170
Pubmed	Opposite impacts of tenascin-C and tenascin-R deficiency in mice on the functional outcome of facial nerve repair.	TNC TNR	5.49e-06	2	82	2	16262655
Pubmed	Tenascins are associated with lipid rafts isolated from mouse brain.	TNC TNR	5.49e-06	2	82	2	12056833
Pubmed	Invasion of melanoma in double knockout mice lacking tenascin-X and tenascin-C.	TNC TNXB	5.49e-06	2	82	2	12359049
Pubmed	Microarray-based identification of tenascin C and tenascin XB, genes possibly involved in tumorigenesis associated with neurofibromatosis type 1.	TNC TNXB	5.49e-06	2	82	2	17202312
Pubmed	The Extracellular Matrix Proteins Tenascin-C and Tenascin-R Retard Oligodendrocyte Precursor Maturation and Myelin Regeneration in a Cuprizone-Induced Long-Term Demyelination Animal Model.	TNC TNR	5.49e-06	2	82	2	35681468
Pubmed	Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina.	SDK2 SDK1	5.49e-06	2	82	2	12230981
Pubmed	Regulation of bone homeostasis by MERTK and TYRO3.	TYRO3 MERTK	5.49e-06	2	82	2	36509738
Pubmed	The change in tenascin expression in mouse uterus during early pregnancy.	TNC TNXB	5.49e-06	2	82	2	9013311
Pubmed	Tenascin C and tenascin R similarly prevent the formation of myelin membranes in a RhoA-dependent manner, but antagonistically regulate the expression of myelin basic protein via a separate pathway.	TNC TNR	5.49e-06	2	82	2	19459213
Pubmed	Distribution of tenascin-C and -X, and soft X-ray analysis of the mandibular symphysis during mandible formation in the human fetus.	TNC TNXB	5.49e-06	2	82	2	15455729
Pubmed	Tenascin variants: ligands and expression.	TNC TNXB	5.49e-06	2	82	2	7509489
Pubmed	The effects of tenascin C knockdown on trabecular meshwork outflow resistance.	TNC TNXB	5.49e-06	2	82	2	23882691
Pubmed	Molecular basis of sidekick-mediated cell-cell adhesion and specificity.	SDK2 SDK1	5.49e-06	2	82	2	27644106
Pubmed	Epithelial-Macrophage Crosstalk Initiates Sterile Inflammation in Embryonic Skin.	TNC MERTK ITGB4	5.63e-06	15	82	3	34721382
Pubmed	Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome.	SLC2A14 SLC2A1 ERVFRD-1	1.00e-05	18	82	3	21729874
Pubmed	Expression of tenascin in developing and adult mouse lymphoid organs.	TNC TNXB	1.64e-05	3	82	2	7687262
Pubmed	Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.	TYRO3 MERTK	1.64e-05	3	82	2	23071254
Pubmed	TAM receptors are dispensable in the phagocytosis and killing of bacteria.	TYRO3 MERTK	1.64e-05	3	82	2	19625016
Pubmed	TAM receptor ligands in lupus: protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus.	TYRO3 MERTK	1.64e-05	3	82	2	20637106
Pubmed	High incidence of distal vaginal atresia in mice lacking Tyro3 RTK subfamily.	TYRO3 MERTK	1.64e-05	3	82	2	18393392
Pubmed	Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis.	TYRO3 MERTK	1.64e-05	3	82	2	37537628
Pubmed	The role of Tyro 3 subfamily receptors in the regulation of hemostasis and megakaryocytopoiesis.	TYRO3 MERTK	1.64e-05	3	82	2	17488688
Pubmed	Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain damage and cell death.	TYRO3 MERTK	1.64e-05	3	82	2	23840307
Pubmed	Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis.	TYRO3 MERTK	1.64e-05	3	82	2	30335822
Pubmed	Glucose transporter GLUT3: ontogeny, targeting, and role in the mouse blastocyst.	SLC2A14 SLC2A1	1.64e-05	3	82	2	9108057
Pubmed	Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation.	TYRO3 MERTK	1.64e-05	3	82	2	25074926
Pubmed	Functions of TAM RTKs in regulating spermatogenesis and male fertility in mice.	TYRO3 MERTK	1.64e-05	3	82	2	19602523
Pubmed	TAM receptor function in the retinal pigment epithelium.	TYRO3 MERTK	1.64e-05	3	82	2	16901715
Pubmed	Tyro-3 family receptors are essential regulators of mammalian spermatogenesis.	TYRO3 MERTK	1.64e-05	3	82	2	10227296
Pubmed	Significant reduction of the GLUT3 level, but not GLUT1 level, was observed in the brain tissues of several scrapie experimental animals and scrapie-infected cell lines.	SLC2A14 SLC2A1	1.64e-05	3	82	2	24243341
Pubmed	Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells.	TYRO3 MERTK	1.64e-05	3	82	2	17442946
Pubmed	GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.	GBP7 GBP3	1.64e-05	3	82	2	35780181
Pubmed	TAM receptors and their ligand-mediated activation: Role in atherosclerosis.	TYRO3 MERTK	1.64e-05	3	82	2	33234243
Pubmed	Post-translational modifications of the ligands: Requirement for TAM receptor activation.	TYRO3 MERTK	1.64e-05	3	82	2	33234244
Pubmed	Recent advancements in role of TAM receptors on efferocytosis, viral infection, autoimmunity, and tissue repair.	TYRO3 MERTK	1.64e-05	3	82	2	33234241
Pubmed	Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases.	TYRO3 MERTK	1.64e-05	3	82	2	16751775
Pubmed	Immunological role of TAM receptors in the cancer microenvironment.	TYRO3 MERTK	1.64e-05	3	82	2	33234245
Pubmed	TAM Receptors Are Not Required for Zika Virus Infection in Mice.	TYRO3 MERTK	1.64e-05	3	82	2	28423319
Pubmed	Glucose transporter expression in brain. cDNA sequence of mouse GLUT3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization.	SLC2A14 SLC2A1	1.64e-05	3	82	2	1730609
Pubmed	TAM receptors in apoptotic cell clearance, autoimmunity, and cancer.	TYRO3 MERTK	1.64e-05	3	82	2	23662598
Pubmed	The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity.	TYRO3 MERTK	1.64e-05	3	82	2	26523970
Pubmed	TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer.	TYRO3 MERTK	1.64e-05	3	82	2	18620092
Pubmed	Glucose transporter isoform-3 mutations cause early pregnancy loss and fetal growth restriction.	SLC2A14 SLC2A1	1.64e-05	3	82	2	17213475
Pubmed	Tenascins and osteopontin in biological response in cornea.	TNC TNXB	1.64e-05	3	82	2	37209968
Pubmed	TAM receptors support neural stem cell survival, proliferation and neuronal differentiation.	TYRO3 MERTK	1.64e-05	3	82	2	25514676
Pubmed	Gestational changes of glucose transporter gene expression in the mouse placenta and decidua.	SLC2A14 SLC2A1	1.64e-05	3	82	2	8905482
Pubmed	The dynamic expression of tenascin-C and tenascin-X during early heart development in the mouse.	TNC TNXB	1.64e-05	3	82	2	12823230
Pubmed	Regular Exercise Enhances Cognitive Function and Intracephalic GLUT Expression in Alzheimer's Disease Model Mice.	SLC2A14 SLC2A1	1.64e-05	3	82	2	31561359
Pubmed	New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis.	TYRO3 MERTK	1.64e-05	3	82	2	32051695
Pubmed	TAM receptor knockout mice are susceptible to retinal autoimmune induction.	TYRO3 MERTK	1.64e-05	3	82	2	21467176
Pubmed	Development of a spontaneous liver disease resembling autoimmune hepatitis in mice lacking tyro3, axl and mer receptor tyrosine kinases.	TYRO3 MERTK	1.64e-05	3	82	2	23799121
Pubmed	The association of Tyro3/Axl/Mer signaling with inflammatory response, disease activity in patients with primary Sjögren's syndrome.	TYRO3 MERTK	1.64e-05	3	82	2	25881761
Pubmed	Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses.	TYRO3 MERTK	1.64e-05	3	82	2	15733062
Pubmed	Hyperglycemia reduces mitochondrial content and glucose transporter expression in mouse embryos developing in vitro.	SLC2A14 SLC2A1	1.64e-05	3	82	2	19550108
Pubmed	Transcriptome analysis of neural progenitor cells by a genetic dual reporter strategy.	TYRO3 MERTK	1.64e-05	3	82	2	21805534
Pubmed	Placental glucose transporter expression is regulated by glucocorticoids.	SLC2A14 SLC2A1	1.64e-05	3	82	2	10199793
Pubmed	TAM receptors Tyro3 and Mer as novel targets in colorectal cancer.	TYRO3 MERTK	1.64e-05	3	82	2	27486820
Pubmed	Reduced extracellular space in the brain of tenascin-R- and HNK-1-sulphotransferase deficient mice.	TNC TNR	1.64e-05	3	82	2	16262627
Pubmed	Tyro3, Axl, and Mertk receptors differentially participate in platelet activation and thrombus formation.	TYRO3 MERTK	1.64e-05	3	82	2	30541554
Pubmed	Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation.	OR2A7 OR2A4	1.64e-05	3	82	2	27315375
Pubmed	Tissue-specific modifier alleles determine Mertk loss-of-function traits.	TYRO3 MERTK	1.64e-05	3	82	2	35969037
Pubmed	TYRO3 as a molecular target for growth inhibition and apoptosis induction in bladder cancer.	TYRO3 MERTK	1.64e-05	3	82	2	30765874
Pubmed	The non-diuretic hypotensive effects of thiazides are enhanced during volume depletion states.	SLC12A3 KCNMA1	1.64e-05	3	82	2	28719636
Pubmed	Glucose transporter proteins in brain.	SLC2A14 SLC2A1	1.64e-05	3	82	2	7926364
Pubmed	Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation.	TYRO3 MERTK	1.64e-05	3	82	2	21192804
Pubmed	GBP3 promotes glioma cell proliferation via SQSTM1/p62-ERK1/2 axis.	GBP7 GBP3	1.64e-05	3	82	2	29128363
Pubmed	TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti-PD-1 Therapy in Melanoma.	TYRO3 MERTK	1.64e-05	3	82	2	31451482
Pubmed	Increased soluble phagocytic receptors sMer, sTyro3 and sAxl and reduced phagocytosis in juvenile-onset systemic lupus erythematosus.	TYRO3 MERTK	1.64e-05	3	82	2	25878564
Pubmed	Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family.	TYRO3 MERTK	1.64e-05	3	82	2	11452127
Pubmed	Increased hematopoietic cells in the mertk-/- mouse peritoneal cavity: a result of augmented migration.	TYRO3 MERTK	1.64e-05	3	82	2	20483720
Pubmed	Vitamin C enters mouse T cells as dehydroascorbic acid in vitro and does not recapitulate in vivo vitamin C effects.	SLC2A14 SLC2A1	1.64e-05	3	82	2	19327547
Pubmed	Glucose Metabolism Is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes.	SLC2A14 SLC2A1	1.64e-05	3	82	2	30765335
Pubmed	Tyro3 family-mediated cell entry of Ebola and Marburg viruses.	TYRO3 MERTK	1.64e-05	3	82	2	17005688
Pubmed	Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.	SLC2A14 SLC2A1	1.64e-05	3	82	2	28746873
Pubmed	Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa.	TYRO3 MERTK	1.64e-05	3	82	2	36662852
Pubmed	Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues.	SLC2A14 SLC2A1	1.64e-05	3	82	2	3170580
Pubmed	The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival.	NR6A1 SLC2A1 ERVFRD-1	3.16e-05	26	82	3	20685850
Pubmed	Analysis of glucose metabolism by 18F-FDG-PET imaging and glucose transporter expression in a mouse model of intracerebral hemorrhage.	SLC2A14 SLC2A1	3.28e-05	4	82	2	34035344
Pubmed	Changes in resting-state functional connectivity after stroke in a mouse brain lacking extracellular matrix components.	TNC TNR	3.28e-05	4	82	2	29367009
Pubmed	Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl.	TYRO3 MERTK	3.28e-05	4	82	2	8621659
Pubmed	Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses.	TNC TNR	3.28e-05	4	82	2	31558805
Pubmed	Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy.	TYRO3 MERTK	3.28e-05	4	82	2	15650770
Pubmed	Role of the Gas6/TAM System as a Disease Marker and Potential Drug Target.	TYRO3 MERTK	3.28e-05	4	82	2	33532004
Pubmed	A zonal organization of odorant receptor gene expression in the olfactory epithelium.	OR2A7 OR2A4	3.28e-05	4	82	2	7683976
Pubmed	Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2.	TNC TNR	3.28e-05	4	82	2	35721494
Pubmed	A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells.	SLC2A14 SLC2A1	3.28e-05	4	82	2	35810171
Pubmed	The Gas6/TAM System and Multiple Sclerosis.	TYRO3 MERTK	3.28e-05	4	82	2	27801848
Cytoband	1p34.2	TMCO2 SZT2 SLC2A1	1.55e-04	57	83	3	1p34.2
Cytoband	1q24	GPR52 TNR	6.01e-04	20	83	2	1q24
GeneFamily	Fibronectin type III domain containing	TYRO3 IGFN1 SDK2 PTPRH PTPRJ TNC INSRR OSMR MERTK TNR ITGB4 TNXB SDK1	4.44e-16	160	51	13	555
GeneFamily	Fibrinogen C domain containing	TNC TNR TNXB	4.65e-05	25	51	3	554
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	TYRO3 IGFN1 SDK2 MERTK SDK1	8.88e-05	161	51	5	593
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	TYRO3 INSRR MERTK	1.94e-04	40	51	3	321
GeneFamily	Solute carriers	SLC12A3 SLC6A16 SLC35D3 SLC30A8 SLC2A14 SLC2A1	8.22e-04	395	51	6	752
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRH PTPRJ	1.58e-03	21	51	2	813
GeneFamily	CD molecules\|Mucins	MUC5B MUC3A	1.58e-03	21	51	2	648
GeneFamily	Immunoglobulin like domain containing	TYRO3 SDK2 MERTK SDK1	2.13e-03	193	51	4	594
GeneFamily	Olfactory receptors, family 2	OR2A7 OR2A4 OR2G2	3.98e-03	113	51	3	149
GeneFamily	Olfactory receptors, family 6	OR6B3 OR6B2	9.11e-03	51	51	2	153
GeneFamily	Immunoglobulin heavy locus at 14q32.33	IGHV2-70 IGHV2-5 IGHV2-70D	1.58e-02	187	51	3	349
GeneFamily	G protein-coupled receptors, Class A orphans	GPR75 GPR52	2.04e-02	78	51	2	262
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TNC GPR75 OSMR ITGB4 SLC2A1 XPR1	1.92e-06	198	83	6	399760b6b6fef8639ded53b14f251b9fce600e81
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Dividing_Basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TDRKH VPS18 CYP2J2 MUC5B PRR11 ITGB4	1.97e-06	199	83	6	f0c289523957258d16135c04679db379d43d28d9
ToppCell	Club_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	PTPRH CYP2J2 MFSD4A MUC5B SDK1	8.78e-06	149	83	5	81c813588bb5efb7b31141a75d387210dcb76094
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SDK2 SLC35D3 INSRR SLC30A8 GPR52	2.07e-05	178	83	5	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SDK2 TNC LRRTM4 TNXB SDK1	2.19e-05	180	83	5	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	SLC12A3 SLC30A8 SLC2A14 MFSD4A XPNPEP2	2.25e-05	181	83	5	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A3 MFSD4A MUC5B ERMP1 LHFPL1	2.37e-05	183	83	5	f3728b1a51951c7349f77a3e4d2671ca3a8d2a44
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TNC GBP3 ITGB4 SLC2A1 TANGO6	2.62e-05	187	83	5	a6a112689d1c9049f57935ad9d2f4955538427de
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TNC LRRTM4 KCNMA1 TNXB SDK1	2.90e-05	191	83	5	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	AT2_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	TNC MFSD4A MUC5B OSMR MUC3A	3.37e-05	197	83	5	5e0d222872a25bb9e9069d3dffda2844bb69874a
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SDK2 TNC OSMR TNXB SDK1	3.53e-05	199	83	5	ba586690f88fd051f449753bfe7603a2cb431782
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SDK2 TNC OSMR TNXB SDK1	3.53e-05	199	83	5	38ed3bc7daa993d9edcf3e7834597ebb06dd24f8
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SDK2 TNC OSMR TNXB SDK1	3.53e-05	199	83	5	06a7d874ff7c4616577f6e59d3118717a8c47c00
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SDK2 TNC OSMR TNXB SDK1	3.53e-05	199	83	5	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PTPRJ KCNMA1 MUC5B CHRM3 DOP1B	3.62e-05	200	83	5	0eb9ad8c0373bcc62029ec21c590ed03aaacd039
Drug	3-ethylpyridine	TNC TNR TNXB	1.43e-07	4	76	3	CID000010823
Drug	AC1O5SNJ	TNC TNR TNXB	7.10e-07	6	76	3	CID006439900
Disease	initial pursuit acceleration	LRRTM4 KCNMA1 TEX51 SPAG16	6.22e-05	87	72	4	EFO_0008434
Disease	Developmental delay (disorder)	SZT2 SLC2A1 STT3B	1.02e-04	37	72	3	C0424605
Disease	hypertension	PTPRJ SZT2 RXFP2 OAS3 CHRM3 TNXB	1.06e-04	307	72	6	EFO_0000537
Disease	Hepatic fibrosis	SDK2 TNR SDK1	2.37e-04	49	72	3	HP_0001395
Disease	tenascin measurement	TNC TNXB	2.61e-04	10	72	2	EFO_0008296
Disease	Cryptorchidism	RXFP2 CHRM3	2.61e-04	10	72	2	C0010417
Disease	pulmonary fibrosis	MUC5B CHRM3	3.18e-04	11	72	2	EFO_0009448
Disease	pancreatic ductal carcinoma (is_marker_for)	ACE2 MUC5B MUC3A	4.53e-04	61	72	3	DOID:3587 (is_marker_for)
Disease	cholangiocarcinoma (is_marker_for)	MFSD4A MUC5B MUC3A	5.22e-04	64	72	3	DOID:4947 (is_marker_for)
Disease	Astrocytosis	TNR ITGB4	7.80e-04	17	72	2	C3887640
Disease	Gliosis	TNR ITGB4	7.80e-04	17	72	2	C0017639
Disease	anorectal malformation	MUC5B CSMD2	9.77e-04	19	72	2	MONDO_0019938
Disease	nucleus accumbens volume	BIRC6 STT3B	1.31e-03	22	72	2	EFO_0006931
Disease	childhood aggressive behaviour measurement	LRRTM4 SDK1 XPR1	1.36e-03	89	72	3	EFO_0007663
Disease	response to venlafaxine	RXFP2 CSMD2	1.70e-03	25	72	2	EFO_0006328
Disease	attention deficit hyperactivity disorder	FBXL16 SPAG16 CSMD2 TNR TANGO6	1.75e-03	354	72	5	EFO_0003888
Disease	Bell's palsy	TYRO3 KCNMA1 SLC2A1	2.01e-03	102	72	3	EFO_0007167
Disease	Early Pregnancy Loss	ACE2 TNR ITGB4	2.43e-03	109	72	3	C3830362
Disease	Miscarriage	ACE2 TNR ITGB4	2.43e-03	109	72	3	C4552766
Disease	Spontaneous abortion	ACE2 TNR ITGB4	2.43e-03	109	72	3	C0000786
Disease	Abortion, Tubal	ACE2 TNR ITGB4	2.43e-03	109	72	3	C0000822

Protein segments in the cluster

Peptide	Gene	Start	Entry
VTNLSASATTRLWAV	BTNL10	191	A8MVZ5
LQLWLTLSLNSSSTG	BIRC6	2661	Q9NR09
TLNSTSSSLWLDFIT	CSMD2	1176	Q7Z408
AGTETTSTTLRWALL	CYP2J2	311	P51589
LLVSSTSWTEFEQLT	ALG1L2	76	C9J202
QTLSAILLAFIITWT	CHRM3	491	P20309
ITLISWFTSLVTVLI	ERMP1	456	Q7Z2K6
WILTEQTTAATTTAT	MUC5B	2991	Q9HC84
TTWILTELTTAATTT	MUC5B	3131	Q9HC84
VLVDTLTSHSFTLSW	OSMR	631	Q99650
NISATSLTLIWKVSD	PTPRJ	376	Q12913
NIDVSTNTTAATLSW	PTPRJ	631	Q12913
AWLSGIATTLVQSTL	OR2G2	151	Q8NGZ5
VNLLSIFISTWLTAA	KCNMA1	301	Q12791
TVNAWISLISITLSG	LRRTM4	296	Q86VH4
RTLAQSLWALFTSSL	MFSD4A	76	Q8N468
SLWALFTSSLAISLV	MFSD4A	81	Q8N468
SIRNSTAHSILISWV	MERTK	291	Q12866
ILPTTLTTLWSLSVA	SLC2A1	56	P11166
LTTLWSLSVAIFSVG	SLC2A1	61	P11166
STLLLLTVPSWVLSQ	IGHV2-70D	6	A0A0C4DH43
TVNLLITSLSTDFLW	DOP1B	431	Q9Y3R5
VSNLTLSSNILTDWT	GLB1	496	P16278
NAILTSFSTIIWSST	MUC3A	2671	Q02505
NDSWIFTLAVLLSST	GBP3	111	Q9H0R5
SDSWIFALAVLLSSS	GBP7	111	Q8N8V2
LWAFLSLVTAVTSST	LHFPL1	11	Q86WI0
STLLLLTVPSWVLSQ	IGHV2-70	6	P01814
ITLAVTSWTTGVLLS	OR2A7	141	Q96R45
VLLTNLWSLSVAIFS	SLC2A14	81	Q8TDB8
PTLSFLTTWLAISNS	GPR52	296	Q9Y2T5
LAFNVVSSTVTQLSW	ITGB4	1226	P16144
LLLWATSFTLATLAT	GPR75	166	O95800
STLLLLTIPSWVLSQ	IGHV2-5	6	P01817
LNWSRLSVSTETLES	LRRC58	16	Q96CX6
ITLAVTSWTTGVLLS	OR2A4	141	O95047
STLTSHTSNLSWISI	OPN4	391	Q9UHM6
TAWTDLLRSALTTIL	HEATR5A	1796	Q86XA9
MSSSSWLLLSLVAVT	ACE2	1	Q9BYF1
WLLLSLVAVTAAQST	ACE2	6	Q9BYF1
VISTSNSSSHLLVRW	INSRR	611	P14616
VTITCRASQSISSWL	IGKV1-5	41	P01602
AILSASSQGITLTWT	IGFN1	751	Q86VF2
LQVTDRSNTSITLSW	IGFN1	851	Q86VF2
IELLTLDASWVSSAS	EMC3	156	Q9P0I2
IVSLLTWVLNTYTST	EXOC3	336	O60645
SLNASATLTVWNRTS	SDK1	561	Q7Z5N4
EAVSSTQILLTWTSV	SDK1	1286	Q7Z5N4
ANVSLRTASETSLWL	SDK2	1101	Q58EX2
LSTWSVLNLLTQGLS	PRRT3	591	Q5FWE3
ENLAIILIVWSSTSL	OR6B2	41	Q6IFH4
VLVTTFSWSNITLLL	MT-ND4	381	P03905
QLVSTALKSWTDVSL	OAS3	531	Q9Y6K5
LNSSTTTLLLSRTWN	MT-ND2	221	P03891
SSTWQELILLSSLTV	NR6A1	321	Q15406
LWSSLSARITSLSVS	FBXL16	236	Q8N461
SLTSLLRDWSSFVLV	SZT2	616	Q5T011
TLQVASLSTSCWETL	UTP20	351	O75691
VAVLSTLQSSLTLWS	SLC35D3	81	Q5M8T2
TLQSSLTLWSLRGLS	SLC35D3	86	Q5M8T2
LLANTSWTGTVISDS	SLC6A16	11	Q9GZN6
EALSAIIASWQSLSS	STK40	326	Q8N2I9
SSSWDNLLESLSLST	TMCO2	6	Q7Z6W1
SLSTSIVWIEDSSSL	RXFP2	721	Q8WXD0
AWALSITLIATSLTS	MT-ND5	406	P03915
ENLAIILTVWSSTSL	OR6B3	41	Q8NGW1
RTSLWAVSLSSALLL	TEX51	136	A0A1B0GUA7
LWRALQSIHTTSTSQ	CLBA1	196	Q96F83
RSLSTSLWSLTHLTA	CNOT6L	46	Q96LI5
SISSLADILVWSETT	TEX44	286	Q53QW1
FAWTIQISITSTTLL	XPR1	571	Q9UBH6
LTSFLLSLFSLWLSS	SLC30A8	111	Q8IWU4
LNSGWILTTTLVLSV	TMEM59	236	Q9BXS4
HWSLITVTLSNRIIS	SENP5	646	Q96HI0
SGTLLLSAAWTLSLS	TMEM235	191	A6NFC5
TSWTSLSTIQKIALG	TDRKH	6	Q9Y2W6
LQISNLSSTAEWVLL	ERVFRD-1	216	P60508
TSISTFLLTRELWNQ	STT3B	181	Q8TCJ2
TQATLLTTWLTELYL	VPS18	486	Q9P253
NTLLTSSADKTLSIW	SPAG16	491	Q8N0X2
LSVTDVTTSSLRLNW	TNXB	3661	P22105
LQVSETAETSLTLLW	TNC	991	P24821
TVLLQAAQDTTWSSI	TNR	1106	Q92752
SLQLHLALTSNSSWV	TPP2	566	P29144
NSVDVTWSFTSQTLL	TANGO6	86	Q9C0B7
TWSFTSQTLLLLLCL	TANGO6	91	Q9C0B7
TWIIILLSVTVTSIT	SLC12A3	171	P55017
STLSSDWQIATLALL	TMEM47	71	Q9BQJ4
LVSESSSQVLWAISS	TMEM109	76	Q9BVC6
SSQVLWAISSAISVA	TMEM109	81	Q9BVC6
GWSVVAQSLLTSTSA	TPTE2P1	111	Q5T6R2
ASWASVLVVSTLAIL	XPNPEP2	656	O43895
LTVETQTTSSISLSW	PTPRH	36	Q9HD43
ISSIDISQSRSWLTS	PRR11	46	Q96HE9
ALLTLIISVTTSWLN	UBXN8	46	O00124
ITVTKLSSSNASVAW	TYRO3	231	Q06418
TTWTIFSIISSTANQ	GARIN5B	276	Q8N5Q1