Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	androsterone dehydrogenase activity	RDH5 AKR1C1 AKR1C2	2.26e-05	8	150	3	GO:0047023
GeneOntologyMolecularFunction	androstan-3-alpha,17-beta-diol dehydrogenase activity	RDH5 AKR1C1 AKR1C2	3.38e-05	9	150	3	GO:0047044
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine phosphatase activity	PTPRU PTPRH PTPRM	2.62e-04	17	150	3	GO:0005001
GeneOntologyMolecularFunction	transmembrane receptor protein phosphatase activity	PTPRU PTPRH PTPRM	2.62e-04	17	150	3	GO:0019198
GeneOntologyMolecularFunction	androsterone dehydrogenase (B-specific) activity	AKR1C1 AKR1C2	3.33e-04	4	150	2	GO:0047042
GeneOntologyMolecularFunction	ketoreductase activity	AKR1C1 AKR1C2	3.33e-04	4	150	2	GO:0045703
GeneOntologyMolecularFunction	indanol dehydrogenase activity	AKR1C1 AKR1C2	3.33e-04	4	150	2	GO:0047718
GeneOntologyMolecularFunction	chlordecone reductase activity	AKR1C1 AKR1C2	3.33e-04	4	150	2	GO:0047743
GeneOntologyMolecularFunction	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	AKR1C1 AKR1C2	5.52e-04	5	150	2	GO:0047115
GeneOntologyMolecularFunction	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	5.52e-04	5	150	2	GO:0047020
GeneOntologyMolecularFunction	17-beta-ketosteroid reductase (NADPH) activity	AKR1C1 AKR1C2	5.52e-04	5	150	2	GO:0072555
GeneOntologyMolecularFunction	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	AKR1C1 AKR1C2	5.52e-04	5	150	2	GO:0047006
GeneOntologyMolecularFunction	lithocholic acid binding	AKR1C1 AKR1C2	5.52e-04	5	150	2	GO:1902121
GeneOntologyMolecularFunction	ketosteroid monooxygenase activity	AKR1C1 AKR1C2	5.52e-04	5	150	2	GO:0047086
GeneOntologyMolecularFunction	Delta4-3-oxosteroid 5beta-reductase activity	AKR1C1 AKR1C2	5.52e-04	5	150	2	GO:0047787
GeneOntologyMolecularFunction	all-trans-retinol dehydrogenase (NAD+) activity	RDH5 AKR1C1 AKR1C2	7.49e-04	24	150	3	GO:0004745
GeneOntologyMolecularFunction	geranylgeranyl reductase activity	AKR1C1 AKR1C2	8.24e-04	6	150	2	GO:0045550
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5C KDM5D	8.24e-04	6	150	2	GO:0034647
GeneOntologyMolecularFunction	alcohol dehydrogenase (NAD+) activity	RDH5 AKR1C1 AKR1C2	9.52e-04	26	150	3	GO:0004022
GeneOntologyMolecularFunction	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	1.15e-03	7	150	2	GO:0072582
GeneOntologyMolecularFunction	alcohol dehydrogenase [NAD(P)+] activity	RDH5 AKR1C1 AKR1C2	1.45e-03	30	150	3	GO:0018455
GeneOntologyMolecularFunction	5alpha-androstane-3beta,17beta-diol dehydrogenase activity	AKR1C1 AKR1C2	1.52e-03	8	150	2	GO:0047024
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5C KDM5D	1.52e-03	8	150	2	GO:0032453
GeneOntologyMolecularFunction	enone reductase activity	AKR1C1 AKR1C2	1.52e-03	8	150	2	GO:0035671
GeneOntologyMolecularFunction	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	RDH5 AKR1C1 AKR1C2	1.92e-03	33	150	3	GO:0033764
GeneOntologyMolecularFunction	NADP+ binding	AKR1C1 AKR1C2	1.95e-03	9	150	2	GO:0070401
GeneOntologyMolecularFunction	coreceptor activity	IL12RB2 PTK7 NRP1 NGFR	2.12e-03	72	150	4	GO:0015026
GeneOntologyMolecularFunction	carbohydrate binding	P3H3 REG3G NOMO1 NOMO2 TKT REG3A LY75 NOMO3	2.42e-03	310	150	8	GO:0030246
GeneOntologyMolecularFunction	testosterone 17-beta-dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	2.42e-03	10	150	2	GO:0047045
GeneOntologyMolecularFunction	bile acid binding	AKR1C1 AKR1C2	2.42e-03	10	150	2	GO:0032052
GeneOntologyMolecularFunction	neuropeptide binding	GRPR OPRL1 KISS1R	2.68e-03	37	150	3	GO:0042923
GeneOntologyBiologicalProcess	cell-cell adhesion	FLNA DLG5 TRAF6 ABCA12 PKD1L1 ITGA10 ADGRV1 ITGA3 PTPRU DCC PTK7 TYK2 DNAJA3 TBX18 PTPN2 NLGN3 HMCN2 PTPRM PKP1 CERCAM REG3A CDH2 FOXF1	1.41e-06	1077	143	23	GO:0098609
GeneOntologyBiologicalProcess	lateral mesoderm development	NOMO1 FOXH1 NOMO3 FOXF1	9.84e-06	20	143	4	GO:0048368
GeneOntologyBiologicalProcess	multi-pass transmembrane protein insertion into ER membrane	NOMO1 NOMO2 NOMO3	2.66e-05	9	143	3	GO:0160063
GeneOntologyBiologicalProcess	determination of left/right asymmetry in lateral mesoderm	NOMO1 FOXH1 NOMO3	3.78e-05	10	143	3	GO:0003140
GeneOntologyBiologicalProcess	detection of monosaccharide stimulus	REG3G REG3A	1.43e-04	3	143	2	GO:0034287
GeneOntologyBiologicalProcess	detection of hexose stimulus	REG3G REG3A	1.43e-04	3	143	2	GO:0009732
GeneOntologyBiologicalProcess	detection of carbohydrate stimulus	REG3G REG3A	1.43e-04	3	143	2	GO:0009730
GeneOntologyBiologicalProcess	positive regulation of detection of glucose	REG3G REG3A	1.43e-04	3	143	2	GO:2000972
GeneOntologyBiologicalProcess	regulation of detection of glucose	REG3G REG3A	1.43e-04	3	143	2	GO:2000970
GeneOntologyBiologicalProcess	detection of glucose	REG3G REG3A	1.43e-04	3	143	2	GO:0051594
GeneOntologyBiologicalProcess	negative regulation of neuron projection development	FLNA RTN4R DCC NRP1 KIAA0319 NLGN3 NGFR	1.80e-04	169	143	7	GO:0010977
GeneOntologyBiologicalProcess	negative regulation of cell projection organization	FLNA RTN4R ITGA3 DCC NRP1 KIAA0319 NLGN3 NGFR	2.26e-04	233	143	8	GO:0031345
GeneOntologyBiologicalProcess	mesenchyme development	FLNA DLG5 PTK7 NOMO1 NRP1 FOXH1 CDH2 NOMO3 FOXF1 FOXF2	2.76e-04	372	143	10	GO:0060485
GeneOntologyBiologicalProcess	response to jasmonic acid	AKR1C1 AKR1C2	2.84e-04	4	143	2	GO:0009753
GeneOntologyBiologicalProcess	progesterone catabolic process	AKR1C1 AKR1C2	2.84e-04	4	143	2	GO:0006709
GeneOntologyBiologicalProcess	cellular response to jasmonic acid stimulus	AKR1C1 AKR1C2	2.84e-04	4	143	2	GO:0071395
GeneOntologyBiologicalProcess	C21-steroid hormone catabolic process	AKR1C1 AKR1C2	2.84e-04	4	143	2	GO:0008208
GeneOntologyCellularComponent	multi-pass translocon complex	NOMO1 NOMO2 NOMO3	2.72e-05	9	146	3	GO:0160064
GeneOntologyCellularComponent	ER membrane insertion complex	NOMO1 NOMO2 NOMO3	1.15e-04	14	146	3	GO:0072379
GeneOntologyCellularComponent	side of membrane	MPL IL12RB2 TRAF6 RTN4R ITGA10 ITGA3 BTN3A2 BTN3A1 TFR2 TYK2 DNAJA3 BTN3A3 CLPTM1 PRSS21 NGFR LY75 TAPBP	1.34e-04	875	146	17	GO:0098552
GeneOntologyCellularComponent	cell surface	MPL IL12RB2 RTN4R ITGA10 ADGRV1 ITGA3 DCC BTN3A2 BTN3A1 TFR2 NRP1 NLGN3 BTN3A3 KISS1R CLPTM1 NGFR LY75 CDH2 TNS1	2.74e-04	1111	146	19	GO:0009986
GeneOntologyCellularComponent	external side of plasma membrane	MPL IL12RB2 RTN4R ITGA10 ITGA3 BTN3A2 BTN3A1 TFR2 BTN3A3 CLPTM1 NGFR LY75	2.93e-04	519	146	12	GO:0009897
Domain	Ig-like_fold	MPL IGSF8 IL12RB2 FLNA PTPRU DCC PKHD1L1 BTN3A2 BTN3A1 PTK7 NOMO1 KIAA0319 IGSF10 BTN3A3 HMCN2 PTPRH PTPRM NOMO2 TAPBP NOMO3	5.64e-07	706	145	20	IPR013783
Domain	DUF2012	NOMO1 NOMO2 NOMO3	1.82e-06	4	145	3	PF09430
Domain	DUF2012	NOMO1 NOMO2 NOMO3	1.82e-06	4	145	3	IPR019008
Domain	-	MPL IGSF8 IL12RB2 FLNA PTPRU DCC PKHD1L1 BTN3A2 BTN3A1 PTK7 NOMO1 IGSF10 BTN3A3 PTPRM NOMO2 TAPBP NOMO3	1.57e-05	663	145	17	2.60.40.10
Domain	Carb-bd-like_fold	NOMO1 NOMO2 NOMO3	2.49e-05	8	145	3	IPR013784
Domain	CarboxyPept_regulatory_dom	NOMO1 NOMO2 NOMO3	1.24e-04	13	145	3	IPR014766
Domain	-	NOMO1 NOMO2 NOMO3	1.24e-04	13	145	3	2.60.40.1120
Domain	PTPc	PTPRU PTPN2 PTPRH PTPRM	1.69e-04	36	145	4	SM00194
Domain	-	B4GALNT4 PKHD1L1	1.79e-04	3	145	2	3.90.182.10
Domain	PA14	B4GALNT4 PKHD1L1	1.79e-04	3	145	2	SM00758
Domain	PA14	B4GALNT4 PKHD1L1	1.79e-04	3	145	2	PF07691
Domain	PA14_dom	B4GALNT4 PKHD1L1	1.79e-04	3	145	2	IPR011658
Domain	TYR_PHOSPHATASE_PTP	PTPRU PTPN2 PTPRH PTPRM	2.32e-04	39	145	4	PS50055
Domain	MAM_1	PTPRU NRP1 PTPRM	2.38e-04	16	145	3	PS00740
Domain	PTPase_domain	PTPRU PTPN2 PTPRH PTPRM	2.82e-04	41	145	4	IPR000242
Domain	Y_phosphatase	PTPRU PTPN2 PTPRH PTPRM	2.82e-04	41	145	4	PF00102
Domain	CarboxyPept-like_regulatory	NOMO1 NOMO2 NOMO3	2.88e-04	17	145	3	IPR008969
Domain	MAM	PTPRU NRP1 PTPRM	2.88e-04	17	145	3	SM00137
Domain	MAM	PTPRU NRP1 PTPRM	3.43e-04	18	145	3	PF00629
Domain	MAM_dom	PTPRU NRP1 PTPRM	3.43e-04	18	145	3	IPR000998
Domain	MAM_2	PTPRU NRP1 PTPRM	3.43e-04	18	145	3	PS50060
Domain	Lys_sp_deMease-like_dom	KDM5C KDM5D	3.56e-04	4	145	2	IPR013637
Domain	PLU-1	KDM5C KDM5D	3.56e-04	4	145	2	PF08429
Domain	zf-C5HC2	KDM5C KDM5D	5.89e-04	5	145	2	PF02928
Domain	Znf_C5HC2	KDM5C KDM5D	5.89e-04	5	145	2	IPR004198
Domain	FN3	MPL IL12RB2 PTPRU DCC KIAA0319 PTPRH PTPRM	6.11e-04	185	145	7	SM00060
Domain	PKD/REJ-like	PKD1L1 KIAA0319	8.80e-04	6	145	2	IPR002859
Domain	REJ	PKD1L1 KIAA0319	8.80e-04	6	145	2	PF02010
Domain	PTPc_motif	PTPRU PTPN2 PTPRM TNS1	1.14e-03	59	145	4	SM00404
Domain	Tyr_Pase_cat	PTPRU PTPN2 PTPRM TNS1	1.14e-03	59	145	4	IPR003595
Domain	FN3_dom	MPL IL12RB2 PTPRU DCC KIAA0319 PTPRH PTPRM	1.25e-03	209	145	7	IPR003961
Pubmed	Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.	NOMO1 NOMO2 NOMO3	8.35e-08	3	153	3	36011023
Pubmed	Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset.	BTN3A2 BTN3A1 BTN3A3	8.35e-08	3	153	3	22767497
Pubmed	Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.	NOMO1 NOMO2 NOMO3	8.35e-08	3	153	3	25576386
Pubmed	Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2.	BTN3A2 BTN3A1 BTN3A3	3.33e-07	4	153	3	39142074
Pubmed	Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.	NOMO1 NOMO2 NOMO3	3.33e-07	4	153	3	31833031
Pubmed	A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.	NOMO1 NOMO2 NOMO3	3.33e-07	4	153	3	9267806
Pubmed	A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors.	RTN4R RTKN NGFR	8.29e-07	5	153	3	15694321
Pubmed	Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology.	BTN3A2 BTN3A1 BTN3A3	8.29e-07	5	153	3	29339503
Pubmed	Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation.	TRAF6 BID SMAD6	8.29e-07	5	153	3	29720226
Pubmed	The cluster of BTN genes in the extended major histocompatibility complex.	BTN3A2 BTN3A1 BTN3A3	2.88e-06	7	153	3	11170752
Pubmed	Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.	NOMO1 NOMO2 NOMO3	4.60e-06	8	153	3	15257293
Pubmed	Substrate-driven assembly of a translocon for multipass membrane proteins.	NOMO1 NOMO2 NOMO3	6.88e-06	9	153	3	36261522
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLNA B4GALNT4 SZT2 APBB3 TRMT11 CEP192 ITGA3 ZNF865 BTN3A2 TYK2 FAM20C GAREM2 ADAMTSL5 MTHFR HELZ2 PDIA5 ABCC10	8.10e-06	1105	153	17	35748872
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	UBE2K SYT12 SZT2 SLC44A2 ZSWIM6 RFC2 NDUFB2 BTN3A1 BUD23 HOXA10 YKT6 TKT PRSS21 PDIA5 SMOX SMAD6	1.21e-05	1021	153	16	26760575
Pubmed	An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.	ITGA3 NOMO1 NOMO2 NOMO3	1.33e-05	33	153	4	30783098
Pubmed	An ER translocon for multi-pass membrane protein biogenesis.	NOMO1 NOMO2 NOMO3	1.34e-05	11	153	3	32820719
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	FLNA RANBP2 KDM5C TRMT11 DHX57 RFC2 HELZ2 ABCC10	1.61e-05	250	153	8	33536335
Pubmed	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	IRF6 MTHFR CLPTM1 PTCH2 PKP1 PAX9 FOXH1 CDH2 FOXF2	1.72e-05	331	153	9	20634891
Pubmed	P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.	RTN4R NGFR	1.92e-05	2	153	2	12422217
Pubmed	Pancreatic islet immunoreactivity to the Reg protein INGAP.	REG3G REG3A	1.92e-05	2	153	2	17998566
Pubmed	Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo.	RTN4R NGFR	1.92e-05	2	153	2	15647357
Pubmed	Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.	AKR1C1 AKR1C2	1.92e-05	2	153	2	8573067
Pubmed	Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.	AKR1C1 AKR1C2	1.92e-05	2	153	2	15492289
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	1.92e-05	2	153	2	10441747
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	1.92e-05	2	153	2	16416087
Pubmed	Targeted expression of islet neogenesis associated protein to beta cells enhances glucose tolerance and confers resistance to streptozotocin-induced hyperglycemia.	REG3G REG3A	1.92e-05	2	153	2	21187123
Pubmed	Genomic structure and refined chromosomal localization of the mouse Ptch2 gene.	MPL PTCH2	1.92e-05	2	153	2	12438747
Pubmed	Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation.	REG3G REG3A	1.92e-05	2	153	2	26867181
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5C KDM5D	1.92e-05	2	153	2	32081420
Pubmed	Forkhead transcription factor FoxF2 is expressed in mesodermal tissues involved in epithelio-mesenchymal interactions.	FOXF1 FOXF2	1.92e-05	2	153	2	10822266
Pubmed	Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP).	REG3G REG3A	1.92e-05	2	153	2	7679928
Pubmed	Modeling single nucleotide polymorphisms in the human AKR1C1 and AKR1C2 genes: implications for functional and genotyping analyses.	AKR1C1 AKR1C2	1.92e-05	2	153	2	21217827
Pubmed	Intestinal microbiota transplantation reveals the role of microbiota in dietary regulation of RegIIIβ and RegIIIγ expression in mouse intestine.	REG3G REG3A	1.92e-05	2	153	2	32560820
Pubmed	Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer.	REG3G REG3A	1.92e-05	2	153	2	8076648
Pubmed	cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family.	AKR1C1 AKR1C2	1.92e-05	2	153	2	8486699
Pubmed	Genetic factors define CPO and CLO subtypes of nonsyndromicorofacial cleft.	IRF6 PAX9	1.92e-05	2	153	2	31609978
Pubmed	The Reg3α (HIP/PAP) Lectin Suppresses Extracellular Oxidative Stress in a Murine Model of Acute Liver Failure.	REG3G REG3A	1.92e-05	2	153	2	25938566
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5C KDM5D	1.92e-05	2	153	2	7524912
Pubmed	Regulation of pancreatitis-associated protein (HIP/PAP) mRNA levels in mouse pancreas and small intestine.	REG3G REG3A	1.92e-05	2	153	2	8795446
Pubmed	Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing.	CFAP47 CCDC187	1.92e-05	2	153	2	25751143
Pubmed	Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.	AKR1C1 AKR1C2	1.92e-05	2	153	2	11514561
Pubmed	Differential role for CD277 as a co-regulator of the immune signal in T and NK cells.	BTN3A2 BTN3A1	1.92e-05	2	153	2	21918970
Pubmed	The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.	BTN3A2 BTN3A1	1.92e-05	2	153	2	22846996
Pubmed	Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease.	REG3G REG3A	1.92e-05	2	153	2	21979939
Pubmed	Nogo receptor antagonizes p75NTR-dependent motor neuron death.	RTN4R NGFR	1.92e-05	2	153	2	18182498
Pubmed	HIP/PAP protects against bleomycin-induced lung injury and inflammation and subsequent fibrosis in mice.	REG3G REG3A	1.92e-05	2	153	2	32352211
Pubmed	Differences in the embryonic expression patterns of mouse Foxf1 and -2 match their distinct mutant phenotypes.	FOXF1 FOXF2	1.92e-05	2	153	2	14745957
Pubmed	Reg3β is associated with cardiac inflammation and provides prognostic information in patients with acute coronary syndrome.	REG3G REG3A	1.92e-05	2	153	2	29544958
Pubmed	The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury.	RTN4R OPRL1	1.92e-05	2	153	2	29615517
Pubmed	MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C, are risks for nonsyndromic cleft lip with or without cleft palate in an Indian population.	IRF6 MTHFR	1.92e-05	2	153	2	19419265
Pubmed	Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment.	REG3G REG3A	1.92e-05	2	153	2	19095652
Pubmed	Symbiotic bacteria direct expression of an intestinal bactericidal lectin.	REG3G REG3A	1.92e-05	2	153	2	16931762
Pubmed	A high-content screening assay for the Nogo receptor based on cellular Rho activation.	RTN4R NGFR	1.92e-05	2	153	2	16712417
Pubmed	cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.	AKR1C1 AKR1C2	1.92e-05	2	153	2	8011662
Pubmed	Nogo-66 Restricts Synaptic Strengthening via Lingo1 and the ROCK2-Cofilin Pathway to Control Actin Dynamics.	RTN4R NGFR	1.92e-05	2	153	2	27166169
Pubmed	Salmonella-induced mucosal lectin RegIIIβ kills competing gut microbiota.	REG3G REG3A	1.92e-05	2	153	2	21694778
Pubmed	Recombinant Reg3α protein protects against experimental acute pancreatitis in mice.	REG3G REG3A	1.92e-05	2	153	2	26683606
Pubmed	CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells.	BTN3A2 BTN3A1	1.92e-05	2	153	2	21113407
Pubmed	Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors.	AKR1C1 AKR1C2	1.92e-05	2	153	2	18654764
Pubmed	The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover.	FLNA NRP1	1.92e-05	2	153	2	24021649
Pubmed	Gastroparesis is associated with decreased FOXF1 and FOXF2 in humans, and loss of FOXF1 and FOXF2 results in gastroparesis in mice.	FOXF1 FOXF2	1.92e-05	2	153	2	30565344
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5C KDM5D	1.92e-05	2	153	2	9060413
Pubmed	The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death.	AKR1C1 AKR1C2	1.92e-05	2	153	2	26934124
Pubmed	MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth.	RTN4R NGFR	1.92e-05	2	153	2	15953414
Pubmed	DmFoxF, a novel Drosophila fork head factor expressed in visceral mesoderm.	FOXF1 FOXF2	1.92e-05	2	153	2	11804790
Pubmed	Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2.	FOXF1 FOXF2	1.92e-05	2	153	2	8626802
Pubmed	Molecular cloning and tissue-specific expression of a new member of the regenerating protein family, islet neogenesis-associated protein-related protein.	REG3G REG3A	1.92e-05	2	153	2	10564727
Pubmed	Pancreatic islet-specific overexpression of Reg3β protein induced the expression of pro-islet genes and protected the mice against streptozotocin-induced diabetes mellitus.	REG3G REG3A	1.92e-05	2	153	2	21245462
Pubmed	An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.	IRF6 AKR1C1 AKR1C2 KISS1R	2.12e-05	37	153	4	21362171
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	IGSF8 RCE1 SYT12 P3H3 ITGA3 BTN3A2 PTK7 NOMO1 NRP1 IGSF10 NOMO2 CLPTM1 PRSS21 PDIA5 CERCAM CDH2 TAPBP	2.35e-05	1201	153	17	35696571
Pubmed	Characterization of HMGB1/2 Interactome in Prostate Cancer by Yeast Two Hybrid Approach: Potential Pathobiological Implications.	FLNA DNAAF2 HOXA10 PTPN2	2.37e-05	38	153	4	31694235
Pubmed	Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth.	PAX9 FOXF1 FOXF2	4.48e-05	16	153	3	19304890
Pubmed	Dengue hemorrhagic fever is associated with polymorphisms in JAK1.	TRAF6 ADAR NRP1 TYK2 AQR	5.29e-05	91	153	5	20588308
Pubmed	Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.	PAX9 FOXF1 FOXF2	5.43e-05	17	153	3	25356765
Pubmed	Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.	AKR1C1 AKR1C2	5.75e-05	3	153	2	19320734
Pubmed	Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction.	REG3G REG3A	5.75e-05	3	153	2	23064197
Pubmed	LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.	RTN4R NGFR	5.75e-05	3	153	2	14966521
Pubmed	Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.	AKR1C1 AKR1C2	5.75e-05	3	153	2	31780644
Pubmed	Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.	AKR1C1 AKR1C2	5.75e-05	3	153	2	13678667
Pubmed	Interleukin 1β regulates progesterone metabolism in human cervical fibroblasts.	AKR1C1 AKR1C2	5.75e-05	3	153	2	22064385
Pubmed	Spatio-temporal profiling of Filamin A RNA-editing reveals ADAR preferences and high editing levels outside neuronal tissues.	FLNA ADAR	5.75e-05	3	153	2	24025532
Pubmed	HIP/PAP gene, encoding a C-type lectin overexpressed in primary liver cancer, is expressed in nervous system as well as in intestine and pancreas of the postimplantation mouse embryo.	REG3G REG3A	5.75e-05	3	153	2	10329612
Pubmed	Myocardial Accumulations of Reg3A, Reg3γ and Oncostatin M Are Associated with the Formation of Granulomata in Patients with Cardiac Sarcoidosis.	REG3G REG3A	5.75e-05	3	153	2	33923774
Pubmed	RIP2 Gates TRAF6 Interaction with Death Receptor p75NTR to Regulate Cerebellar Granule Neuron Survival.	TRAF6 NGFR	5.75e-05	3	153	2	30044969
Pubmed	Molecular dissection of the myelin-associated glycoprotein receptor complex reveals cell type-specific mechanisms for neurite outgrowth inhibition.	RTN4R NGFR	5.75e-05	3	153	2	17470639
Pubmed	Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration.	RTN4R NGFR	5.75e-05	3	153	2	11201742
Pubmed	LINGO-1 protein interacts with the p75 neurotrophin receptor in intracellular membrane compartments.	RTN4R NGFR	5.75e-05	3	153	2	25666623
Pubmed	Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart.	REG3G REG3A	5.75e-05	3	153	2	25751817
Pubmed	p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I.	REG3G REG3A	5.75e-05	3	153	2	14660681
Pubmed	Foxf2 and Smad6 co-regulation of collagen 5A2 transcription is involved in the pathogenesis of intrauterine adhesion.	FOXF2 SMAD6	5.75e-05	3	153	2	32022446
Pubmed	Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.	AKR1C1 AKR1C2	5.75e-05	3	153	2	21232532
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5C KDM5D	5.75e-05	3	153	2	7544442
Pubmed	Slc44a2 deletion alters tetraspanin and N-cadherin expression: Reduced adhesion and enhanced proliferation in cultured mesenchymal lung cells.	SLC44A2 CDH2	5.75e-05	3	153	2	34371293
Pubmed	Dual Function of NRP1 in Axon Guidance and Subcellular Target Recognition in Cerebellum.	PTF1A NRP1	5.75e-05	3	153	2	27618676
Pubmed	Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease.	REG3G REG3A	5.75e-05	3	153	2	30106382
Pubmed	SNPs and interaction analyses of IRF6, MSX1 and PAX9 genes in patients with non‑syndromic cleft lip with or without palate.	IRF6 PAX9	5.75e-05	3	153	2	23921572
Pubmed	A cross-ethnicity investigation of genes previously implicated in primary angle closure glaucoma.	MFRP MTHFR	5.75e-05	3	153	2	22933837
Pubmed	Axonal injury mediated by neuronal p75NTR/TRAF6/JNK pathway contributes to cognitive impairment after repetitive mTBI.	TRAF6 NGFR	5.75e-05	3	153	2	38029807
Pubmed	EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5.	IGSF8 ITGA3	5.75e-05	3	153	2	14662754
Pubmed	Human brain factor 1, a new member of the fork head gene family.	FOXF1 FOXF2	5.75e-05	3	153	2	7959731
Cytoband	10p15-p14	AKR1C1 AKR1C2	1.64e-04	6	153	2	10p15-p14
GeneFamily	Butyrophilins\|V-set domain containing\|C2-set domain containing	BTN3A2 BTN3A1 BTN3A3	6.11e-05	15	95	3	458
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRU PTPRH PTPRM	1.75e-04	21	95	3	813
GeneFamily	Fibronectin type III domain containing	MPL IL12RB2 PTPRU DCC PTPRH PTPRM	1.99e-04	160	95	6	555
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	MPL IGSF8 ITGA3 BTN3A1 NRP1 NGFR LY75 CDH2	1.10e-03	394	95	8	471
GeneFamily	UPF1 like RNA helicases	HELZ2 AQR	1.46e-03	11	95	2	1169
GeneFamily	Forkhead boxes	FOXH1 FOXF1 FOXF2	1.49e-03	43	95	3	508
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	DCC PTK7 IGSF10 HMCN2 PTPRM	1.60e-03	161	95	5	593
GeneFamily	AT-rich interaction domain containing	KDM5C KDM5D	2.74e-03	15	95	2	418
GeneFamily	Aldo-keto reductases	AKR1C1 AKR1C2	2.74e-03	15	95	2	399
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA10 ITGA3	3.96e-03	18	95	2	1160
GeneFamily	Proteases, serine	TMPRSS11B PRSS47P PRSS21	4.44e-03	63	95	3	738
Coexpression	GSE2405_S_AUREUS_VS_A_PHAGOCYTOPHILUM_NEUTROPHIL_DN	PLXDC1 SZT2 APBB3 DHX57 KLHL22 MTHFR PI4KB HELZ2	2.08e-05	200	150	8	M6208
Coexpression	KANG_IMMORTALIZED_BY_TERT_DN	SMG1 RDH5 OPRL1 TFR2 NRP1 CDH2	2.57e-05	101	150	6	M1514
Coexpression	PEREZ_TP53_AND_TP63_TARGETS	RTN4R NLRP1 ZSWIM6 KISS1R NGFR FOXF1 FOXF2 SMAD6	2.66e-05	207	150	8	M14566
Coexpression	DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN	FLNA P3H3 KDM5C PTK7 NOMO1 TYK2 PI4KB ABCC10 AQR	3.18e-05	276	150	9	M3063
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PLXDC1 ABCA12 BAAT RDH5 PTPRH VILL	1.54e-07	70	153	6	8d6bdf2e773e894a0db39fdff1fafc2474e03fcf
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	VIPR1 BAAT RDH5 DCC PKHD1L1 VILL	2.72e-07	77	153	6	a799ccdb84014e978d9fbccf3d2fee8fbeac7b0c
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	B4GALNT4 KDM5C SEC14L6 PTCH2 NGFR SMOX PPP1R27	1.02e-06	153	153	7	92a5307b8e4dcf9ee42134b4c0645f9d488df61a
ToppCell	(7)_Epithelial-H_(AT1)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	ABCA12 IRF6 ITGA3 CROT NGFR PKP1 PAX9	3.50e-06	184	153	7	1f76b37c265b519171b767a52d48f31f0cdc4a3c
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IRF6 ITGA3 AKR1C1 AKR1C2 TKT NGFR PKP1	5.66e-06	198	153	7	22935a8afac54021f68b5f7a5accf51523e2f336
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DLG5 IRF6 ITGA3 AKR1C1 AKR1C2 NGFR PKP1	5.85e-06	199	153	7	c88a28a73f54dc571f2ff1e4b55073f83cbead2c
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	RBM11 PLXDC1 P3H3 TBX18 ADAMTSL5 NGFR PPP1R12C	6.05e-06	200	153	7	f7c3a8f5ac156c05ad7335d6d142c154c7d86449
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	IL12RB2 FLNA DLG5 ADAR BTN3A2 BTN3A1 BTN3A3	6.05e-06	200	153	7	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IRF6 ITGA3 AKR1C2 CROT NGFR PKP1 PAX9	6.05e-06	200	153	7	2a9d715aba8bdef2341b0d44ff60825c074a4b03
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Basal_2\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	SLC7A4 NGFR PKP1 CDH2 PPP1R27 CNDP1	1.50e-05	153	153	6	a44da11a913b19edde6c5d1d6e625c24b20ecbfd
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Basal_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SLC7A4 NGFR PKP1 CDH2 PPP1R27 CNDP1	2.14e-05	163	153	6	f21951e63188eb0c04675a8f81a0da495c26c007
ToppCell	normal-na-Lymphocytic_NK-NK_bright-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	IL12RB2 PKD1L1 CDC20B KDM5D HOXA10 PTPN2	2.22e-05	164	153	6	b5a91f2cbfad9a2bc38aea576085a37865df955d
ToppCell	LPS-IL1RA-Epithelial_airway-Club_cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 AKR1C1 TMPRSS11B VILL PKP1 PAX9	2.30e-05	165	153	6	1a114eacaab598f755a173a3fed842ba91f689dd
ToppCell	LPS-IL1RA-Epithelial_airway-Club_cells-Airway\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 AKR1C1 TMPRSS11B VILL PKP1 PAX9	2.30e-05	165	153	6	9cfd3c1d2c6d714fde83b90465f1f9741b0e50ce
ToppCell	Basal_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	HGFAC PLXDC1 ABCA12 NGFR PKP1 PAX9	2.54e-05	168	153	6	48089fa2d4a0f31a72405717119b767a92571f01
ToppCell	facs-Marrow-T-cells-24m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF8 C16orf96 NRP1 NGFR CDH2 TNS1	3.00e-05	173	153	6	ca3d2a9562734f76127e3e7d54c10b63e95141bb
ToppCell	facs-Marrow-T-cells-24m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF8 C16orf96 NRP1 NGFR CDH2 TNS1	3.00e-05	173	153	6	19a9e10885173d7712996be8660a3a5a7a9aa39f
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IRF6 PTPRU NGFR PKP1 PAX9 CDH2	3.41e-05	177	153	6	cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IRF6 PTPRU NGFR PKP1 PAX9 CDH2	3.41e-05	177	153	6	ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL5A3 ARSI PTK7 CERCAM CDH2 FOXF2	3.74e-05	180	153	6	935c091bbcd6d10b81dc4731779e5bd98205c99f
ToppCell	5'-Airway_Nasal-Mesenchymal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL5A3 ARSI PTK7 CERCAM CDH2 FOXF2	3.74e-05	180	153	6	3dd384b7f3d9582b8fec9fe05100e466e6218b76
ToppCell	droplet-Kidney-nan-21m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXDC1 P3H3 HOXA10 NLGN3 ABCC10 PLCE1	4.10e-05	183	153	6	ad7421623e4c0c5ba02eec56e9bdae43ebb88d90
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP13A4 ABCA12 ADGRV1 DCC PKHD1L1 PLCE1	4.23e-05	184	153	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP13A4 ABCA12 ADGRV1 DCC PKHD1L1 PLCE1	4.23e-05	184	153	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP13A4 ABCA12 ADGRV1 DCC PKHD1L1 PLCE1	4.23e-05	184	153	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	356C-Endothelial_cells-Endothelial-E-\|356C / Donor, Lineage, Cell class and subclass (all cells)	SYT12 HMCN2 PTPRM PKP1 FOXF1 TECPR1	4.49e-05	186	153	6	2e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell	356C-Endothelial_cells-Endothelial-E\|356C / Donor, Lineage, Cell class and subclass (all cells)	SYT12 HMCN2 PTPRM PKP1 FOXF1 TECPR1	4.49e-05	186	153	6	c3449e54454009973818fc1101933c6f0168258c
ToppCell	367C-Epithelial_cells-Epithelial-H_(AT1)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	ATP13A4 ABCA12 IRF6 ITGA3 PKP1 PAX9	4.77e-05	188	153	6	61422c7919ca0ea02d6be4302f11b169a3ce35e5
ToppCell	367C-Epithelial_cells-Epithelial-H_(AT1)\|367C / Donor, Lineage, Cell class and subclass (all cells)	ATP13A4 ABCA12 IRF6 ITGA3 PKP1 PAX9	4.77e-05	188	153	6	18698f0b22ccbc2b93759acc1c8dbdb30a6b5a16
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	VIPR1 ITGA10 ITGA3 PTPRM FOXF1 SMAD6	4.91e-05	189	153	6	b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCell	facs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLXDC1 ITGA3 NRP1 ADAMTSL5 FOXF1 SMAD6	5.05e-05	190	153	6	52213cd2a6a20772d4f49ba9ac0407abafa528db
ToppCell	IPF-Epithelial-Basal\|IPF / Disease state, Lineage and Cell class	IRF6 ITGA3 PTPRU NGFR PKP1 PAX9	5.05e-05	190	153	6	ea19e9ce954f2dfde97388db9695325cd92ab88f
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	VIPR1 ITGA10 ITGA3 PTPRM FOXF1 SMAD6	5.05e-05	190	153	6	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA PLXDC1 COL5A3 TBX18 TNS1 PLCE1	5.05e-05	190	153	6	5681c211baeed4af82a2bbc13420f6a7b487581c
ToppCell	LAM-Epithelial-AT1\|LAM / Condition, Lineage and Cell class	ATP13A4 BAAT ITGA3 PTPRU AKR1C1 TNS1	5.20e-05	191	153	6	66875b2ec2c510489407f3e433a90cdf74a15094
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	VIPR1 ITGA10 ITGA3 PTPRM FOXF1 SMAD6	5.20e-05	191	153	6	f229abf69a1217194f74b0502486907e07dba989
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VIPR1 NLRP1 PKHD1L1 PTPRM PDIA5 SMAD6	5.51e-05	193	153	6	456aa8a8f1f9cbba0bd618a5f623909079c0f56b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VIPR1 SLC44A2 NLRP1 PTPRM PDIA5 SMAD6	5.84e-05	195	153	6	23ced69fd904f1d4114b1a7f99f4b5f65ea8824b
ToppCell	droplet-Bladder-Unstain-18m\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA IRF6 ITGA3 PKP1 SMOX CDH2	6.01e-05	196	153	6	0d040ae2ce8a0e1a59145a9b9eaa979239c477ff
ToppCell	Basal_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	DLG5 IRF6 CROT NGFR PKP1 PAX9	6.01e-05	196	153	6	3b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLNA RDH5 ITGA3 IGSF10 FAM20C CDH2	6.01e-05	196	153	6	b8b9801181d7604871b48aebacb295d0a57a5eaf
ToppCell	droplet-Bladder-Unstain\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA IRF6 ITGA3 PKP1 SMOX CDH2	6.01e-05	196	153	6	f240056e63aca02f25ea29bc9d34eedcf0f1c811
ToppCell	Parenchymal-10x5prime-Stromal-Mesofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DPYS REG3G PKHD1L1 TBX18 SMOX CDH2	6.18e-05	197	153	6	88a86286b9c3ea3b076d7464faec42d0392ee7f8
ToppCell	Parenchymal-10x5prime-Stromal-Mesofibroblastic-Mesothelia\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DPYS REG3G PKHD1L1 TBX18 SMOX CDH2	6.18e-05	197	153	6	2773d2eb5f232a7e49da116efffcb6bf5eb90810
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NRP1 HOXA10 PTCH2 NGFR CERCAM C1QTNF4	6.18e-05	197	153	6	2744cc94883c5d0424677cf5093bbab622933e9b
ToppCell	cellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IRF6 AKR1C1 AKR1C2 VILL PKP1 PAX9	6.35e-05	198	153	6	6e047de63ef59dcb47e4fc06b173b2a02fdcf4c9
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_basal-Suprabasal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA12 IRF6 AKR1C2 NGFR PKP1 PAX9	6.35e-05	198	153	6	de5987588b9fa9ee8c595ba06d7d844ead0e3c74
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IRF6 AKR1C1 AKR1C2 NGFR PKP1 PAX9	6.35e-05	198	153	6	240e1aa0594ee6de530b2f97d5e392c5fcbf278b
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	ATP13A4 NOXA1 PTPRU CERCAM HPS5 PLCE1	6.35e-05	198	153	6	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	cellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IRF6 AKR1C1 CROT NGFR PKP1 PAX9	6.35e-05	198	153	6	7063d74d79f53d5c59c853a2575f9d3ef12f19ea
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLNA PLXDC1 P3H3 COL5A3 PTK7 FOXF2	6.35e-05	198	153	6	eb78b2ae6a787dbc75947e8dd5a03693285bc8be
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IRF6 AKR1C1 AKR1C2 NGFR PKP1 PAX9	6.35e-05	198	153	6	9a229167d4da4abf8c336dfe5cfdf57db756fc8b
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA12 IRF6 AKR1C2 CROT PKP1 PLCE1	6.35e-05	198	153	6	19d8ff3a4f911b13ecc34844202925475ad4d2ab
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IRF6 ITGA3 AKR1C1 AKR1C2 NGFR PKP1	6.35e-05	198	153	6	fc00cb25cdc6c31b7f9d397bc9f9a8f4e9708003
ToppCell	normal_Lung-Endothelial_cells-Tip-like_ECs\|Endothelial_cells / Location, Cell class and cell subclass	VIPR1 ITGA3 BTN3A2 NRP1 BTN3A3 FOXF1	6.53e-05	199	153	6	72c96a5954dfcfbfee8f095984ce1f5249d9a679
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	VIPR1 ITGA10 ITGA3 NRP1 FOXF1 SMAD6	6.53e-05	199	153	6	1621ce2968f3100e4c39e0ef8293232a5d76c614
ToppCell	Tracheal-10x3prime_v2-Stromal-Schwann-Schwann_nonmyelinating\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SLC44A2 TRMT11 COL5A3 ARSI DNAJA3 CDH2	6.53e-05	199	153	6	a92718a3f1153b8d2196fd343ed5bc0ebc98cad7
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLNA ITGA3 TFR2 NRP1 FAM20C SMOX	6.53e-05	199	153	6	85bb28369e0568b7b3bda095722102fc793f60ef
ToppCell	Tracheal-10x3prime_v2-Stromal-Schwann\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SLC44A2 TRMT11 COL5A3 ARSI DNAJA3 CDH2	6.53e-05	199	153	6	8dc65662c3ca1db2ba0091332f0658abc0afc5de
ToppCell	Parenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	VIPR1 ITGA10 ITGA3 NRP1 FOXF1 SMAD6	6.71e-05	200	153	6	3653002c805c314043e2a7b0c9980dfe952dc53e
ToppCell	Biopsy_Other_PF-Epithelial-KRT5-/KRT17+\|Biopsy_Other_PF / Sample group, Lineage and Cell type	SYT12 ABCA12 BAAT IRF6 ITGA3 CDH2	6.71e-05	200	153	6	077e6b9340686de9d0f11b035a8954e1f6a1b790
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial-Proteoglycan-expressing_cell\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	PLXDC1 ITGA10 TFR2 TBX18 ADAMTSL5 FOXF2	6.71e-05	200	153	6	aafe594c88710f8c53d59667cdac5035e08f5511
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	RBM11 PLXDC1 TBX18 ADAMTSL5 NGFR PPP1R12C	6.71e-05	200	153	6	24e13b6d9d2d8b29df1f02544ea9c50084d9e75c
ToppCell	Biopsy_IPF-Epithelial-Basal\|Biopsy_IPF / Sample group, Lineage and Cell type	IRF6 AKR1C2 CROT NGFR PKP1 PAX9	6.71e-05	200	153	6	5cea84581201cee7ba8141b96e65864f4fd67113
ToppCell	Parenchyma_COVID-19-Epithelial-TX-Basal_1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	IRF6 ITGA3 CROT NGFR PKP1 PAX9	6.71e-05	200	153	6	592c7c3ded409a9957cbcdc62fcc213fa8eae598
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_basal-Basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IRF6 ITGA3 CROT NGFR PKP1 PAX9	6.71e-05	200	153	6	9da214f756a03516eaafde00289b90f69623b9f3
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DLG5 IRF6 CROT VILL PKP1 PAX9	6.71e-05	200	153	6	8827653738a931e4a4545e0c7d75be12bed40740
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-Basal_1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IRF6 ITGA3 CROT NGFR PKP1 PAX9	6.71e-05	200	153	6	8cfbde43c5e66269ad128aa5398b1517667d7d36
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	PLXDC1 ITGA10 TFR2 TBX18 ADAMTSL5 FOXF2	6.71e-05	200	153	6	a6f0f5f644b7262878b0b9d4d90ee407c4124dd9
ToppCell	distal-2-Epithelial-Basal\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SYT12 IRF6 RTKN PTK7 NGFR PAX9	6.71e-05	200	153	6	9beb128841c50241aa819261f21bf66f881ea125
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-Basal_1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	IRF6 ITGA3 CROT NGFR PKP1 PAX9	6.71e-05	200	153	6	61811380d9252f12f27b7ad4752380b52692677f
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Neuron\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	VIPR1 RTKN NRP1 PTPRM NGFR	8.35e-05	129	153	5	64768adf23123b92280fb30eb85147cbee084ae0
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	IRF6 RAD54B HELZ2 LY75 FOXF1	9.31e-05	132	153	5	06e7337de35bd7120655a22b6020604ad004c4e1
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 RBM11 PRSS21 PDIA5 CNDP1	1.15e-04	138	153	5	611fe0fb284e12678f9c47a0bdbfc367a93c52b3
ToppCell	COVID-19-Fibroblasts-Mesothelial_FB\|COVID-19 / group, cell type (main and fine annotations)	DPYS REG3G PKHD1L1 TBX18 CDH2	1.27e-04	141	153	5	7e6dcccb74e7ee90b69dc91b59491b84f3a713c9
ToppCell	droplet-Liver-Npc-21m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIPR1 RDH5 DHX57 RFTN2	1.30e-04	75	153	4	7f3be37cc378ee115fcb4b0eb9653fc77447aa0a
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	IRF6 RAD54B HELZ2 FOXF1 SMAD6	1.40e-04	144	153	5	1c118b22c2ff3a526a5207d6c9d772636ee065fd
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-Monocytes-Macrophages\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AOAH CDC20B NLRP1 HMCN2 NGFR	1.49e-04	146	153	5	b76110b159acd27a2c8d6a9f98336608ace1ec12
ToppCell	Lymphoid-Lymphoid-NK_cells\|Lymphoid / shred on cell class and cell subclass (v4)	AOAH REG3G OTOP3 CROT TNS1	1.59e-04	148	153	5	d51a4b654a88d58dcdf29c2bc362c0cc1c40723a
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	IRF6 RAD54B HELZ2 FOXF1 SMAD6	1.64e-04	149	153	5	d9c47f523c75ddcd6131e45d2ffc24b970932cae
ToppCell	LPS-antiTNF-Endothelial-Epi-like-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BAAT KIAA0319 DNAJA3 KISS1R VILL	1.70e-04	150	153	5	9cb3332924bd67c966873343c14445e30d3f384f
ToppCell	PBMC-Severe-cDC_1\|Severe / Compartment, Disease Groups and Clusters	FLNA NLRP1 ADAR NOMO2	1.75e-04	81	153	4	6d1e524f000b71c935359afc801a1d31f218fec8
ToppCell	MS-CD4-antiviral_CD4\|MS / Condition, Cell_class and T cell subcluster	ETV7 DCC ADAMTSL5 NOMO2 HELZ2	1.80e-04	152	153	5	b1eba2d5a6da3eeb83d40a92976e3e8751ed18ee
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_CT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SYT12 PLXDC1 PTK7 NRP1 PTCH2	2.03e-04	156	153	5	fe383ce3a0c37f7343d7026cb51260a04d4c2829
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RANBP2 PTF1A AOAH RDH5 HPS5	2.16e-04	158	153	5	12661763d1c309106801cb710c04cd2b62d16cba
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RANBP2 PTF1A AOAH RDH5 HPS5	2.16e-04	158	153	5	e7db50d6dfaf7280a73a0d5b5aa4f43ea2762d72
ToppCell	Leuk-UTI-Lymphocyte-B-Plasmablast\|Leuk-UTI / Disease, Lineage and Cell Type	PKHD1L1 PNPO TFR2 SMOX TNS1	2.16e-04	158	153	5	05a29c2d5506a25ccdfa4c6a86e9188977a18272
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RANBP2 PTF1A AOAH RDH5 HPS5	2.16e-04	158	153	5	0792c39e6fc0745095af7812de2d50949540d60f
ToppCell	Basal_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	NGFR PKP1 C1QTNF4 PAX9 PLCE1	2.16e-04	158	153	5	dd069a822e9698e6dddc155d9a5b52383f7879d5
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ARSI OPRL1 HMCN2 PDIA5 SMAD6	2.29e-04	160	153	5	19105debef96ea0c267d6a1d332303ec668ae47e
ToppCell	wk_15-18-Hematologic-Meg-ery-Platelet\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MPL TRAF6 PKHD1L1 GRPR TFR2	2.29e-04	160	153	5	768f3cefc3ad4cda229e598cce8bde574cf64bb2
ToppCell	RV-13._Vascular_Smooth_Muscle\|RV / Chamber and Cluster_Paper	FLNA ITGA3 HMCN2 FOXF1 PLCE1	2.35e-04	161	153	5	47b3b7662cbb671ccc086dc0a0cabd65f63eb5a1
ToppCell	lymphoid-B_cell-pro-B\|World / Lineage, cell class and subclass	RTKN HOXA10 NGFR C1QTNF4 CDH2	2.35e-04	161	153	5	23138e579f07d5a6f20d41457cb573b4ac95a4ef
ToppCell	Control-Epithelial-Ionocyte\|Control / Disease state, Lineage and Cell class	RTKN SLC7A4 NGFR PAX9 CDH2	2.49e-04	163	153	5	bf09fa39bf3e6b3a776d5e79c30c96df572956a3
ToppCell	wk_20-22-Hematologic-Myeloid-HSC\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MPL HOXA10 TKT PRSS21 C1QTNF4	2.56e-04	164	153	5	a35a0725b8bfe3cad5b85484217fd8a02bdee827
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_TNFAIP8L3\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CFAP47 HGFAC GAREM2 PSKH2 MINDY1	2.64e-04	165	153	5	cd73bba51f3f4871533c3512bdc0a1f05716344b
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	P3H3 ETV7 ZNF865 NGFR FOXF1	2.64e-04	165	153	5	9d2bdc42c13c8c2a68889bec8612a1ce56f659fa
ToppCell	facs-Lung-Endomucin-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIPR1 NLRP1 ZNF865 FAM20C CERCAM	2.71e-04	166	153	5	a2ce44702a0cd5fa5872cac3302d3c451205feef
ToppCell	facs-Lung-Endomucin-3m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIPR1 NLRP1 ZNF865 FAM20C CERCAM	2.71e-04	166	153	5	0f641302a6b71c4badaaf20f51162bfc2386b167
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AKR1C1 AKR1C2 TMPRSS11B VILL PKP1	2.71e-04	166	153	5	1df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
Disease	Neoplasms, Hormone-Dependent	AKR1C1 AKR1C2	7.37e-05	3	147	2	C0027661
Disease	sciatic neuropathy (biomarker_via_orthology)	REG3G OPRL1 NLGN3 NGFR REG3A	1.41e-04	99	147	5	DOID:11446 (biomarker_via_orthology)
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5C KDM5D	1.47e-04	4	147	2	DOID:0060809 (implicated_via_orthology)
Disease	systemic lupus erythematosus, COVID-19	IL12RB2 RFTN2 BTN3A1 TYK2	2.04e-04	58	147	4	MONDO_0007915, MONDO_0100096
Disease	hypertension, pregnancy-induced	MTHFR PLCE1	2.44e-04	5	147	2	MONDO_0024664
Disease	Hermaphroditism	AKR1C1 AKR1C2	2.44e-04	5	147	2	C0019269
Disease	Ambiguous Genitalia	AKR1C1 AKR1C2	2.44e-04	5	147	2	C0266362
Disease	Pseudohermaphroditism	AKR1C1 AKR1C2	2.44e-04	5	147	2	C0033804
Disease	acute pancreatitis (implicated_via_orthology)	REG3G REG3A	2.44e-04	5	147	2	DOID:2913 (implicated_via_orthology)
Disease	Intersex Conditions	AKR1C1 AKR1C2	2.44e-04	5	147	2	C2930618
Disease	Sex Differentiation Disorders	AKR1C1 AKR1C2	2.44e-04	5	147	2	C2930619
Disease	Disorders of Sex Development	AKR1C1 AKR1C2	5.09e-04	7	147	2	C0036875
Disease	pneumonia (implicated_via_orthology)	REG3G REG3A	1.08e-03	10	147	2	DOID:552 (implicated_via_orthology)
Disease	glomerulonephritis (is_implicated_in)	MTHFR CNDP1	1.32e-03	11	147	2	DOID:2921 (is_implicated_in)
Disease	SCHIZOPHRENIA	RTN4R MTHFR	1.32e-03	11	147	2	181500
Disease	Crohn's disease of large bowel	TYK2 PTPN2 MTHFR	1.38e-03	44	147	3	C0156147
Disease	IIeocolitis	TYK2 PTPN2 MTHFR	1.38e-03	44	147	3	C0949272
Disease	Crohn's disease of the ileum	TYK2 PTPN2 MTHFR	1.38e-03	44	147	3	C0267380
Disease	Regional enteritis	TYK2 PTPN2 MTHFR	1.38e-03	44	147	3	C0678202
Disease	Oligodontia	IRF6 PAX9	1.57e-03	12	147	2	C4082304
Disease	craniosynostosis (is_implicated_in)	FLNA SMAD6	1.57e-03	12	147	2	DOID:2340 (is_implicated_in)
Disease	Crohn Disease	TYK2 PTPN2 MTHFR	2.00e-03	50	147	3	C0010346
Disease	cardiovascular disease	HGFAC OPRL1 ABHD16B TBC1D1 NDUFAF6 C1QTNF4 ABCC10 PLCE1	2.13e-03	457	147	8	EFO_0000319
Disease	Hypodontia	IRF6 PAX9	2.16e-03	14	147	2	C0020608
Disease	cleft lip (is_implicated_in)	IRF6 MTHFR	2.48e-03	15	147	2	DOID:9296 (is_implicated_in)
Disease	response to olanzapine	IGSF8 ADGRV1	2.48e-03	15	147	2	GO_0097333
Disease	Acute Cerebrovascular Accidents	MTHFR SMOX FOXF2	2.49e-03	54	147	3	C0751956
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C KDM5D	2.83e-03	16	147	2	DOID:0050888 (implicated_via_orthology)
Disease	preeclampsia, hypertension, pregnancy-induced	MTHFR PLCE1	2.83e-03	16	147	2	EFO_0000668, MONDO_0024664
Disease	response to methotrexate	AKR1C1 AKR1C2	2.83e-03	16	147	2	GO_0031427
Disease	platelet crit	MPL HGFAC UBE2K ADGRV1 TFR2 BID TYK2 PTPRH PDIA5 LY75 ABCC10 PLCE1	2.98e-03	952	147	12	EFO_0007985
Disease	Endometrial Neoplasms	AKR1C1 HOXA10 MTHFR	3.06e-03	58	147	3	C0014170
Disease	apolipoprotein A 1 measurement	HGFAC UBE2K ITGA10 PTPRU ADAR NRP1 BTN3A3 SEC14L6 CLPTM1 NDUFAF6 MINDY1	3.57e-03	848	147	11	EFO_0004614
Disease	sweet liking measurement	DCC KISS1R	3.58e-03	18	147	2	EFO_0010156
Disease	Schizophrenia	RTN4R MTHFR	3.58e-03	18	147	2	cv:C0036341
Disease	mean arterial pressure	UBE2K SZT2 MTHFR NDUFAF6 TNS1 ABCC10 PLCE1 TRMT61A	3.64e-03	499	147	8	EFO_0006340
Disease	Cerebrovascular accident	MTHFR SMOX FOXF2	3.70e-03	62	147	3	C0038454
Disease	Liver carcinoma	VIPR1 HGFAC PLXDC1 AKR1C2 BID HOXA10 PKP1 CNDP1	4.01e-03	507	147	8	C2239176
Disease	bone mineral content measurement	UBE2K NLRP1 ADGRV1 TNS1	4.13e-03	130	147	4	EFO_0007621
Disease	Global developmental delay	SZT2 KDM5C PNPO CDH2	4.48e-03	133	147	4	C0557874
Disease	Lymphoma, Diffuse	MTHFR RAD54B	4.86e-03	21	147	2	C3714542
Disease	Low Grade Lymphoma (neoplasm)	MTHFR RAD54B	4.86e-03	21	147	2	C0079747
Disease	Lymphoma, Intermediate-Grade	MTHFR RAD54B	4.86e-03	21	147	2	C0079741
Disease	High Grade Lymphoma (neoplasm)	MTHFR RAD54B	4.86e-03	21	147	2	C0079740
Disease	Diffuse Mixed-Cell Lymphoma	MTHFR RAD54B	4.86e-03	21	147	2	C0079757
Disease	Lymphoma, Undifferentiated	MTHFR RAD54B	4.86e-03	21	147	2	C0024306
Disease	Reticulosarcoma	MTHFR RAD54B	4.86e-03	21	147	2	C0024302
Disease	Lymphoma, Mixed-Cell	MTHFR RAD54B	4.86e-03	21	147	2	C0024304

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSDEGHYWVGLDISP	BUD23	71	O43709
NWTLLSYPGAGHLIE	BAAT	351	Q14032
SSYAGPATLHPIWGS	CCDC187	976	A0A096LP49
GIHLECRSTGWYPQP	BTN3A3	161	O00478
APSSPGGSTHAWLYL	BLACE	86	A4D250
GIHLECRSTGWYPQP	BTN3A1	161	O00481
HITDWYPTLVGLAGG	ARSI	346	Q5FYB1
EVHSFASGQALPWGP	ATP13A4	511	Q4VNC1
WHRGYDSGNVFLPPV	ABCA12	966	Q86UK0
SPGWPEAFVLHLSGV	ADGRV1	4966	Q8WXG9
LDYGDTVWLRLHGAP	C1QTNF4	126	Q9BXJ3
IGRPSTEHSWFPGYA	CRBN	371	Q96SW2
HGPYVITGDYPRSLW	LINC00518	76	Q8N0U6
WLHDIILGYGDPSSA	AQR	686	O60306
HVGSWQVPLLGHYPD	SLC7A4	156	O43246
APLEAGYSVLGWNHP	ABHD16B	191	Q9H3Z7
FPPAHLVVYGWSVGG	ABHD16B	236	Q9H3Z7
GGSHLILYDIDWNPA	RAD54B	731	Q9Y620
ASPHRWPTENYGPDS	RANBP2	836	P49792
HVPDLEAGPSSYKWT	RBM11	176	P57052
VLPGDYEILATHPTW	NOMO3	176	P69849
LGQLSYLAPGEDGHW	NOXA1	351	Q86UR1
TDYGPLLHTLAEFGW	RFTN2	356	Q52LD8
LETPPHWAAYDTGLE	P3H3	211	Q8IVL6
HYTTWPDFGVPESPA	PTPN2	176	P17706
SHVILYGLPDGTFLW	AOAH	411	P28039
EDASYSVPAPWHGRR	MFRP	41	Q9BY79
PLPLWEGDTTGHCFT	ABCC10	16	Q5T3U5
LYQDPHAGPLWVRGS	OTOP3	151	Q7RTS5
RHGDGGYWPVDTNLI	DCC	1056	P43146
GGPLYIDVTWHPAGD	MTHFR	86	P42898
VLPGDYEILATHPTW	NOMO2	176	Q5JPE7
PYHSPKVEEWSSLGR	PAX9	216	P55771
YTGEPWPSISHLAKD	PSKH2	281	Q96QS6
YDVWVSHPRDLAAPG	FOXH1	341	O75593
RGAAPGSHWSLPYSL	DNAAF2	111	Q9NVR5
GSHWSLPYSLAPGRE	DNAAF2	116	Q9NVR5
LEPPHWGADETSGLL	HMCN2	1246	Q8NDA2
EPIAASLGTDGTHYW	DPYS	271	Q14117
DEGYPRPHSHLLSWG	HPS5	941	Q9UPZ3
WTVLPAGDLPTHDGY	IL12RB2	786	Q99665
PKTWYGVPSLAAEHL	KDM5D	521	Q9BY66
GSLYVWKSELPRDHP	RCE1	51	Q9Y256
LYPTEITVHGNGSWP	ITGA3	831	P26006
LPGIPGLEAYHIWLS	OR52B2	16	Q96RD2
IPHGGDGTWRYLNID	NAT16	286	Q8N8M0
HFPVAGSYRWPNTGL	NLRP1	1101	Q9C000
GPGAWGTDHYCLELL	NDUFAF6	51	Q330K2
VLPGDYEILATHPTW	NOMO1	176	Q15155
SPELQEWAPYSPGHS	DLG5	1146	Q8TDM6
QALGPAGSWHPRSYA	KISS1R	286	Q969F8
LYHGWLVDPQSPEAV	MINDY1	236	Q8N5J2
DTHLRGYALWPEQGP	LMLN2	156	A0A1B0GTW7
IHGPPLIIEGSEYWF	LY75	811	O60449
GAHGYGPSPIDLWLD	HOXA10	106	P31260
TFGRPAEWPGYLSHL	PNPO	11	Q9NVS9
PGSHPWLAAIYIGDS	HGFAC	416	Q04756
PGEEPCWGDSHEYRL	ADAMTSL5	76	Q6ZMM2
NGHWVVSPPGTYEAA	ADAMTSL5	251	Q6ZMM2
PHAGYARPWSPAEDS	ADAMTSL5	456	Q6ZMM2
YGLPPLAGHSLSWTD	PTF1A	271	Q7RTS3
WPEHGVPYHATGLLA	PTPRU	1051	Q92729
LEIWDGFPDVGPHIG	NRP1	211	O14786
PAWSDAAHGDEVPYV	NLGN3	516	Q9NZ94
LPPGWRKIHDAAGTY	APBB3	31	O95704
GDPTPHVDWLLADGS	IGSF10	501	Q6WRI0
ALPPAGRHAAYSVGW	IGSF8	331	Q969P0
YDPGSNTWHTLADGP	KLHL22	466	Q53GT1
GDVYRQGTTPPIWHL	ADAR	341	P55265
FGHLDDPGLARWTPG	ETV7	171	Q9Y603
WHYEVPELLPEGSSA	C16orf96	281	A6NNT2
WHPEIVYSGGDDGLL	DPH7	206	Q9BTV6
DWPHAGAEGAEFLSP	FAM20C	201	Q8IXL6
KWGDEHIPGSPYRVV	FLNA	2631	P21333
EWIVDGKHSYPPGAI	DHX57	836	Q6P158
NDDWSHPGILYVIPA	GRPR	31	P30550
AGREGWAFLPESPHT	C2CD4D	86	B7Z1M9
GIHLECRSTGWYPQP	BTN3A2	161	P78410
GHELPVLAPQWEGYD	BID	41	P55957
LVQYGESPVHEWSLG	ITGA10	206	O75578
WHLSSLAPPYVKGVD	CEP192	2306	Q8TEP8
DGLLTIWPHDPGASA	CDC20B	376	Q86Y33
GYVAVGIIAWTHGDP	SLC44A2	46	Q8IWA5
HSLWAQLGGYPDIPR	FAM186A	2311	A6NE01
PGLNVDPGTYTWVAH	HELZ2	2031	Q9BYK8
PLLAAPTHYAGDAEW	CERCAM	531	Q5T4B2
HSYWKGGPTVDPEEL	DNAJA3	171	Q96EY1
SPVWYHIVGSLDPKG	SEC14L6	96	B5MCN3
LFGWPEGPHSFSIPE	CFAP47	1546	Q6ZTR5
WFYGPVDLHVGPDEI	CFAP47	2356	Q6ZTR5
PPGGGLWVEVYANHV	PKD1L1	46	Q8TDX9
PHTPAWNAVYRISGG	CDH2	411	P19022
STLGIPTWELFPEGH	COL5A3	71	P25940
WLQGFGPPSVYHAAI	MFSD14C	36	Q5VZR4
GHPVYGEEAWKSATP	FAM166A	151	Q6J272
VPETPWADEGGSVYH	PDIA5	266	Q14554
EHYWPPKEGTQLERG	CROT	111	Q9UKG9
WPDHGVPYHATGLLG	PTPRM	1061	P28827
YIWIGLHDPTQGSEP	REG3G	101	Q6UW15
AQVDSGLYPGLIWLH	IRF6	16	O14896
PAPFWEVIYGSHLQG	OPRL1	6	P41146
GRPGKGHYWTIDPAS	FOXF2	166	Q12947
PEEETNPKGSGWLYH	PKP1	531	Q13835
EIPYEELWAHQGPEG	GAREM2	426	Q75VX8
PGKGHYWTIDPASEF	FOXF1	116	Q12946
ASHEENPAWLPLYGS	RTKN	281	Q9BST9
VATGPYHPIWTGRAT	RTN4R	311	Q9BZR6
YHPIWTGRATDEEPL	RTN4R	316	Q9BZR6
FDPAAWLHGPPETSG	SZT2	2856	Q5T011
PGGPEHNEYALVSAW	SZT2	3131	Q5T011
AEYHLSVIKSPPGWE	SYT12	6	Q8IV01
YVWIGLHDPTQGTEP	REG3A	101	Q06141
LWGHGQSPEELYSSL	TRMT11	76	Q7Z4G4
GELWLPHGTVATPVF	QTRT1	31	Q9BXR0
YDPELRDGDGWTPLH	PPP1R12C	251	Q9BZL4
EPDGVWAYNRGEHPI	SMAD6	396	O43541
LPSGHIGLTAWSYID	PLCE1	351	Q9P212
PPPEWLHDKYDTTGE	PTCH2	881	Q9Y6C5
YLEHGLETTPTAPWR	SMG1	1806	Q96Q15
GLASWGLDCRHPAYP	PRSS47P	291	A8MTI9
IYLSKPTHWERDGAP	POLR2B	91	P30876
GDAPLGRSHYWPSQS	PROSER3	16	Q2NL68
EGSPYGHLPNWRLLS	PI4KB	546	Q9UBF8
WARLPPATQAHYGGA	RDH5	226	Q92781
LSCGSSPRDPHGYWE	B4GALNT4	946	Q76KP1
YSALGSHREEPWVDP	AKR1C1	216	Q04828
YSALGSHREEPWVDP	AKR1C2	216	P52895
AEDYGPVEVISHWHP	CLPTM1	226	O96005
LWRYPSLSIHGIEGA	CNDP1	341	Q96KN2
DRIDWPVGSPATIHY	YKT6	106	O15498
AGWTPLHIACSDGYP	PPP1R27	96	Q86WC6
YLRAEHWGASPSGAP	TLX1NB	41	P0CAT3
TDEGWTHLEPGPYPI	VIPR1	106	P32241
AFPTPQWGIVDLSGH	ZNF865	141	P0CJ78
SGGPLAYPDSRNIWH	TMPRSS11B	366	Q86T26
GHAAPILYAVWAEAG	TKT	76	P29401
GDTWRHLAGELGYQP	NGFR	356	P08138
RVYIHPDSPASGETW	TBX18	221	O95935
GLEEPYGVDDHPLWA	TECPR1	521	Q7Z6L1
LVSHFYPSGGLEVEW	TAPBP	316	O15533
GEYDSHLPWPFQGTI	TRAF6	416	Q9Y4K3
GRGGWVYVLHPTPEL	TRMT61A	61	Q96FX7
EGLAGYQREGPHPAW	TNS1	586	Q9HBL0
EEHEIGPSLYAAPWF	TBC1D1	956	Q86TI0
LGHFPYPDPSQWTDE	NDUFB2	81	O95178
PPERYGHVLSGWICG	SMOX	416	Q9NWM0
PGPVYDCLVWHDGEV	TPP2	191	P29144
GEGEITTIYHHPLPW	TTC41P	1251	Q6P2S7
KAPGSAGHYELPWVE	RFC2	26	P35250
SVHGLGYAWSPPVLN	PKHD1L1	1401	Q86WI1
APGTVHSYLGSPFWI	MPL	371	P40238
HFWEALGGRAPYPSN	VILL	586	O15195
RLWAHVYAGAPVSSP	UBE2K	146	P61086
EGWVGHPLDPVGTLF	ZSWIM6	626	Q9HCJ5
WGYIKEDEALPSPHT	PRSS21	176	Q9Y6M0
LYGPSEPHSRELWVD	PLXDC1	96	Q8IUK5
YQAWPDHGVPSSPDT	PTPRH	981	Q9HD43
EAPGPVHVYWLLDGA	PTK7	56	Q13308
APQEWQGSLLGSPYH	TFR2	376	Q9UP52
LVSWYGLEHGQPPIE	USP11	166	P51784
PEDGLYLIHWSTSHP	TYK2	466	P29597
PKTWYGVPSLAAEHL	KDM5C	531	P41229
DHQIVLYEWSLGPGS	KIAA0319	556	Q5VV43