Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
HumanPhenoCaesarian section

SATB1 PTCD3

8.05e-051552HP:0011410
HumanPhenoEnterocolitis

STAT1 NLRC4

1.45e-042052HP:0004387
HumanPhenoAcute colitis

STAT1 NLRC4

1.45e-042052HP:0100282
HumanPhenoAbnormal delivery

SATB1 PTCD3 ASH1L

2.17e-0414553HP:0001787
HumanPhenoVillous atrophy

STAT1 NLRC4

2.29e-042552HP:0011473
HumanPhenoAbnormal small intestinal villus morphology

STAT1 NLRC4

2.29e-042552HP:0011472
HumanPhenoAbnormal small intestinal mucosa morphology

STAT1 NLRC4

2.88e-042852HP:0025129
Domain-

HHIP TENM2

1.90e-03393122.120.10.30
Domain6-blade_b-propeller_TolB-like

HHIP TENM2

2.64e-0346312IPR011042
PathwayBIOCARTA_CHEMICAL_PATHWAY

EIF2S1 STAT1

2.33e-0418182MM1350
PathwayBIOCARTA_CHEMICAL_PATHWAY

EIF2S1 STAT1

2.33e-0418182M3873
Pubmed

Gene expression changes in cancellous bone of type 2 diabetics: a biomolecular basis for diabetic bone disease.

SATB1 STAT1

2.31e-06331224715035
Pubmed

Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria.

STAT1 NLRC4

2.76e-05931223853600
Pubmed

The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells.

L3MBTL3 MIER1

4.21e-051131233097091
Pubmed

Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study.

EIF2S1 STAT1

4.21e-051131212447867
Pubmed

An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers.

EPC2 MIER1

6.95e-051431228981838
Pubmed

Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.

EPC2 TENM2 STAT1 ASH1L

7.83e-0525731430945288
Pubmed

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.

STAT1 NLRC4

1.04e-041731225774715
Pubmed

ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.

STAT1 NLRC4

2.28e-042531227917412
Pubmed

Suppressing UPR-dependent overactivation of FGFR3 signaling ameliorates SLC26A2-deficient chondrodysplasias.

HHIP STAT1

2.47e-042631230685387
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

EPC2 MCTP1 DNTTIP2 NUFIP1 PTCD3 ASH1L

3.98e-04111631631753913
Pubmed

Blockade of TNF receptor superfamily 1 (TNFR1)-dependent and TNFR1-independent cell death is crucial for normal epidermal differentiation.

STAT1 NLRC4

4.49e-043531229596938
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

SATB1 L3MBTL3 STAT1 DNTTIP2

6.28e-0444431434795231
CytobandEnsembl 112 genes in cytogenetic band chr3p25

EMC3 C3orf20

4.94e-03155312chr3p25
ToppCellLymphoid-Lymphoid-T_cells_(Cd4+_Tnaive-Tcm)|Lymphoid / shred on cell class and cell subclass (v4)

SLC44A2 LIMD2 SATB1 CYP2E1 MIER1

6.74e-08153315ffb8ac88513e83d3ba01574e60beb5476154372b
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIMD2 SATB1 MIER1 STAT1

7.16e-06180314de87503d9caac3ebc80ab8090c1a9ee5a925b2a0
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MCTP1 STAT1 KSR2 EML6

8.51e-06188314e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MCTP1 STAT1 KSR2 EML6

8.87e-0619031411d3c31167ea71809b4cc3757a0c6ea54a448602
Diseasereticulocyte measurement

SLC44A2 L3MBTL3 STAT1 NUFIP1 EML6 SPDYE3 ASH1L

5.66e-051053297EFO_0010700
Disease3-hydroxypropylmercapturic acid measurement

EMC3 MCTP1 FRMD6 KSR2

3.74e-04352294EFO_0007014
Diseaseresponse to angiotensin receptor blocker

TENM2 EML6

3.99e-0430292EFO_0010735
Diseasereticulocyte count

SLC44A2 L3MBTL3 STAT1 NUFIP1 EML6 ASH1L

4.59e-041045296EFO_0007986
Diseasethreonine measurement

MANEA STAT1

6.08e-0437292EFO_0009775
DiseaseDuchenne muscular dystrophy, disease progression measurement

SATB1 PREP

1.11e-0350292EFO_0008336, MONDO_0010679
Diseasedepressive disorder (biomarker_via_orthology)

CYP2E1 PREP

1.20e-0352292DOID:1596 (biomarker_via_orthology)
Diseasechronic obstructive pulmonary disease (is_implicated_in)

HHIP CYP2E1

1.76e-0363292DOID:3083 (is_implicated_in)
DiseaseJT interval

SLC27A6 PREP SPDYE3

1.82e-03248293EFO_0007885
Diseaseresponse to angiotensin-converting enzyme inhibitor

HHIP PREP

2.67e-0378292EFO_0005325
Diseaselongitudinal BMI measurement

NUFIP1 KSR2

2.95e-0382292EFO_0005937
Diseaseneuroimaging measurement

HHIP SLC27A6 L3MBTL3 STAT1 KSR2

3.56e-031069295EFO_0004346
Diseaselean body mass

SLC44A2 HHIP L3MBTL3

6.00e-03379293EFO_0004995
Diseasebirth weight

HHIP L3MBTL3 STAT1

6.91e-03399293EFO_0004344
DiseaseAstigmatism

TENM2 EML6

7.13e-03129292HP_0000483

Protein segments in the cluster

PeptideGeneStartEntry
KYSDFNASPFRKHFK

nan

241

A8MVM7
YNRLYKGEFKQPKQF

EPC2

86

Q52LR7
KKDFSPHYVPDNYKR

ASH1L

2821

Q9NR48
NENGKFKYSDYFKPF

CYP2E1

416

P05181
FKEHQSFPYNKNGFK

L3MBTL3

251

Q96JM7
KLFEAPSFFQKYKHY

PAPOLB

361

Q9NRJ5
KFIGPDQHRNFYYSK

PTCD3

446

Q96EY7
SDPYVKFRLGHQKYK

MCTP1

491

Q6DN14
FYCKPHFQQLFKSKG

LIMD2

86

Q9BT23
KPKYKFFHKSFQEYT

NLRC4

436

Q9NPP4
KYKRPGYGAYDAFKH

EIF2S1

141

P05198
QKNFNLPASHYYKYK

KSR2

556

Q6VAB6
GNHPAFYRYKTKTGN

MANEA

246

Q5SRI9
YDYPKYSCHFKKGKR

PREP

71

P48147
NFKRNKHYGKYFEPE

FRMD6

166

Q96NE9
VDKGYKNQSFYRKHF

GUCD1

91

Q96NT3
KFKGQYFHSRDYKNP

FMO5

166

P49326
GKAPKKAFKFHYTFY

C3orf20

366

Q8ND61
QKGTKNENKPYLFYF

SLC44A2

76

Q8IWA5
SYPVKGQHARFKKYV

EML6

1221

Q6ZMW3
RKYYFNNPEDGFFKK

EMC3

76

Q9P0I2
YDFFAQQTRFGKKKY

MIER1

336

Q8N108
IDKDHAFGKYYSRPK

STAT1

671

P42224
NKEFKHSNNPAHKYY

TENM2

1276

Q9NT68
SLAFHPNYKKNGKLY

HHIP

286

Q96QV1
KFFQNQRYYLKHHGK

SATB1

691

Q01826
YKKNDRDGFPKYFQI

DNTTIP2

676

Q5QJE6
NPKRKKDYHNYQTLF

NUFIP1

431

Q9UHK0
APKQKIFYFLYGKTH

SPDYE3

461

A6NKU9
YQKIHTREKPFGYNK

ZNF582

161

Q96NG8
KPFQANSHFVKFKYA

TMEM81

136

Q6P7N7
KNPFFGYAGPYKHTK

SLC27A6

431

Q9Y2P4