Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	serpin family protein binding	CTSL CTSV	8.29e-06	2	58	2	GO:0097655
GeneOntologyMolecularFunction	cysteine-type carboxypeptidase activity	CTSL CTSV	4.96e-05	4	58	2	GO:0016807
GeneOntologyMolecularFunction	kininogen binding	CTSL CTSV	8.25e-05	5	58	2	GO:0030984
GeneOntologyMolecularFunction	cysteine-type exopeptidase activity	CTSL CTSV	3.68e-04	10	58	2	GO:0070004
GeneOntologyBiologicalProcess	elastin metabolic process	ATP7A CTSL CTSV	7.13e-06	14	57	3	GO:0051541
GeneOntologyCellularComponent	somatodendritic compartment	EPHB2 MYH10 CAD ATP7A SLC12A2 PRKAA2 REG1B CTSL CTSV ADCY2 SLC9A6 ALOX5 GABRA5	2.02e-05	1228	57	13	GO:0036477
GeneOntologyCellularComponent	neuronal cell body	EPHB2 MYH10 CAD ATP7A SLC12A2 PRKAA2 REG1B CTSL CTSV GABRA5	7.70e-05	835	57	10	GO:0043025
GeneOntologyCellularComponent	cell body	EPHB2 MYH10 CAD ATP7A SLC12A2 PRKAA2 REG1B CTSL CTSV GABRA5	1.85e-04	929	57	10	GO:0044297
GeneOntologyCellularComponent	cell body membrane	SLC12A2 REG1B GABRA5	2.86e-04	47	57	3	GO:0044298
GeneOntologyCellularComponent	late endosome	SLC9A9 ATP7A RASGEF1B CTSL CTSV SLC9A6	3.62e-04	348	57	6	GO:0005770
GeneOntologyCellularComponent	cerebellar climbing fiber to Purkinje cell synapse	ADGRB3 PLXNA4	3.95e-04	11	57	2	GO:0150053
GeneOntologyCellularComponent	dendrite	EPHB2 MYH10 ATP7A PRKAA2 REG1B ADCY2 SLC9A6 ALOX5 GABRA5	4.86e-04	858	57	9	GO:0030425
GeneOntologyCellularComponent	dendritic tree	EPHB2 MYH10 ATP7A PRKAA2 REG1B ADCY2 SLC9A6 ALOX5 GABRA5	4.94e-04	860	57	9	GO:0097447
GeneOntologyCellularComponent	nuclear matrix	CAD SF3B1 BCL11A ALOX5	5.78e-04	140	57	4	GO:0016363
GeneOntologyCellularComponent	axon	EPHB2 MYH10 CAD ATP7A POLG PRKAA2 SH2D3C REG1B SLC9A6	6.37e-04	891	57	9	GO:0030424
GeneOntologyCellularComponent	nuclear periphery	CAD SF3B1 BCL11A ALOX5	1.22e-03	171	57	4	GO:0034399
GeneOntologyCellularComponent	pigment granule membrane	TYR ATP7A	1.63e-03	22	57	2	GO:0090741
GeneOntologyCellularComponent	chitosome	TYR ATP7A	1.63e-03	22	57	2	GO:0045009
GeneOntologyCellularComponent	melanosome membrane	TYR ATP7A	1.63e-03	22	57	2	GO:0033162
GeneOntologyCellularComponent	asymmetric, glutamatergic, excitatory synapse	ADGRB3 PLXNA4	1.94e-03	24	57	2	GO:0098985
MousePheno	dental pulp necrosis	FAM20C NOTUM CTSL CTSV	3.51e-10	5	42	4	MP:0013251
MousePheno	abnormal dental pulp morphology	FAM20C NOTUM CTSL CTSV	3.42e-08	12	42	4	MP:0013250
MousePheno	abnormal dental pulp cavity morphology	FAM20C NOTUM CTSL CTSV	1.25e-07	16	42	4	MP:0002819
MousePheno	abnormal ligament morphology	SLC12A2 NOTUM CTSL CTSV GABRA5	3.31e-07	49	42	5	MP:0005504
MousePheno	abnormal periodontal ligament morphology	NOTUM CTSL CTSV	7.06e-06	13	42	3	MP:0003668
MousePheno	periodontal ligament necrosis	CTSL CTSV	8.81e-06	2	42	2	MP:0030515
MousePheno	abnormal circulating ceruloplasmin level	ATP7A CP	8.81e-06	2	42	2	MP:0020986
MousePheno	abnormal lymph node medullary sinus morphology	CTSL CTSV	8.81e-06	2	42	2	MP:0011222
MousePheno	dilated lymph node medullary sinus	CTSL CTSV	8.81e-06	2	42	2	MP:0011223
MousePheno	tooth abscess	FAM20C NOTUM	8.81e-06	2	42	2	MP:0030462
MousePheno	apical tooth abscess	FAM20C NOTUM	8.81e-06	2	42	2	MP:0030463
MousePheno	decreased ceruloplasmin level	ATP7A CP	8.81e-06	2	42	2	MP:0012612
MousePheno	abnormal ceruloplasmin level	ATP7A CP	8.81e-06	2	42	2	MP:0012611
MousePheno	decreased circulating ceruloplasmin level	ATP7A CP	8.81e-06	2	42	2	MP:0012661
MousePheno	postnatal lethality, incomplete penetrance	FAM20C MYH10 ATP7A SLC12A2 NOTUM SPEF2 SMARCAD1 CTSL CTSV SLC9A6	2.15e-05	669	42	10	MP:0011086
MousePheno	abnormal exocrine gland physiology	FAM20C SLC12A2 CTSL CTSV ELAC2 PRLR	2.43e-05	196	42	6	MP:0013559
MousePheno	abnormal merocrine gland physiology	SLC12A2 CTSL CTSV PRLR	3.04e-05	60	42	4	MP:0013557
MousePheno	abnormal hair texture	ATP7A CTSL CTSV PRLR	3.69e-05	63	42	4	MP:0002074
MousePheno	hearing/vestibular/ear phenotype	EPHB2 TYR FAM20C SLC12A2 POLG ATG2B REG1B PRAMEF17 CTSL CTSV GABRA5	5.26e-05	905	42	11	MP:0005377
MousePheno	abnormal male reproductive gland morphology	TYR FAM20C SLC12A2 POLG RAB11FIP2 SH2D3C PLXNA4 PRAMEF17 CTSL CTSV ELAC2 PRLR GABRA5	6.60e-05	1290	42	13	MP:0013325
MousePheno	folliculitis	CTSL CTSV	8.76e-05	5	42	2	MP:0000376
MousePheno	hair follicle outer root sheath hyperplasia	CTSL CTSV	8.76e-05	5	42	2	MP:0010688
MousePheno	enlarged thymus cortex	CTSL CTSV	8.76e-05	5	42	2	MP:0013593
MousePheno	abnormal liver copper level	ATP7A CP	1.31e-04	6	42	2	MP:0003065
MousePheno	abnormal periodontium morphology	NOTUM CTSL CTSV	1.41e-04	34	42	3	MP:0030131
MousePheno	abnormal internal male genitalia morphology	TYR FAM20C SLC12A2 POLG RAB11FIP2 SH2D3C PLXNA4 PRAMEF17 CTSL CTSV ELAC2 PRLR GABRA5	1.44e-04	1392	42	13	MP:0009205
MousePheno	abnormal sensory neuron innervation pattern	EPHB2 SH2D3C PLXNA4 GABRA5	1.62e-04	92	42	4	MP:0000968
MousePheno	abnormal exocrine gland morphology	EPHB2 TYR FAM20C SLC12A2 POLG PRAMEF17 CTSL CTSV ELAC2 PRLR	1.67e-04	853	42	10	MP:0013558
MousePheno	abnormal male genitalia morphology	TYR FAM20C SLC12A2 POLG RAB11FIP2 SH2D3C PLXNA4 PRAMEF17 CTSL CTSV ELAC2 PRLR GABRA5	1.70e-04	1415	42	13	MP:0009198
MousePheno	abnormal male reproductive system morphology	TYR FAM20C SLC12A2 POLG RAB11FIP2 SH2D3C PLXNA4 PRAMEF17 CTSL CTSV ELAC2 PRLR GABRA5	1.70e-04	1415	42	13	MP:0001145
MousePheno	abnormal gland physiology	FAM20C SLC12A2 POLG PRKAA2 REG1B CTSL CTSV ELAC2 PRLR	1.72e-04	691	42	9	MP:0002164
MousePheno	abnormal type IV spiral ligament fibrocytes	SLC12A2 GABRA5	1.83e-04	7	42	2	MP:0004296
MousePheno	mitral valve regurgitation	CTSL CTSV	1.83e-04	7	42	2	MP:0006045
MousePheno	abnormal R wave	CTSL CTSV	1.83e-04	7	42	2	MP:0011919
MousePheno	mottled coat	TYR ATP7A	1.83e-04	7	42	2	MP:0000421
MousePheno	small spleen	EPHB2 ATP7A NOTUM PLXNA4 ALOX5 NSD3 GABRA5	2.15e-04	416	42	7	MP:0000692
MousePheno	abnormal axial skeleton morphology	FAM20C MYH10 CFAP54 ATP7A SF3B1 NOTUM SPEF2 POLG GMPR SMARCAD1 CTSL CTSV ALOX5	2.30e-04	1458	42	13	MP:0002114
MousePheno	dilated piliary canal	CTSL CTSV	2.44e-04	8	42	2	MP:0030571
MousePheno	sparse vibrissae	CTSL CTSV	2.44e-04	8	42	2	MP:0001283
MousePheno	variegated coat color	TYR ATP7A	2.44e-04	8	42	2	MP:0005366
MousePheno	enlarged heart	MYH10 POLG ATG2B FGB CP SMARCAD1 PRAMEF17 CTSL CTSV GABRA5	2.98e-04	916	42	10	MP:0000274
MousePheno	abnormal T wave	CTSL CTSV	3.13e-04	9	42	2	MP:0010505
MousePheno	increased heart left atrium size	CTSL CTSV	3.13e-04	9	42	2	MP:0008726
MousePheno	hypergranulosis	CTSL CTSV	3.13e-04	9	42	2	MP:0009600
MousePheno	focal dorsal hair loss	CTSL CTSV	3.13e-04	9	42	2	MP:0010202
MousePheno	abnormal hair cycle catagen phase	CTSL CTSV	3.13e-04	9	42	2	MP:0008859
MousePheno	coarse hair	ATP7A PRLR	3.13e-04	9	42	2	MP:0002832
MousePheno	lethality during fetal growth through weaning, incomplete penetrance	FAM20C MYH10 ATP7A SLC12A2 NOTUM SPEF2 SH2D3C SMARCAD1 CTSL CTSV SLC9A6	3.61e-04	1124	42	11	MP:0011112
MousePheno	abnormal copper level	ATP7A CP	3.91e-04	10	42	2	MP:0003952
MousePheno	abnormal lymph node medulla morphology	CTSL CTSV	3.91e-04	10	42	2	MP:0002348
MousePheno	abnormal anterior commissure pars posterior morphology	EPHB2 PLXNA4	3.91e-04	10	42	2	MP:0010860
MousePheno	stereotypic behavior	EPHB2 SLC9A9 SLC12A2 CTSL CTSV	4.30e-04	214	42	5	MP:0001408
MousePheno	cardiac interstitial fibrosis	MYH10 CTSL CTSV	4.48e-04	50	42	3	MP:0005608
MousePheno	dilated heart	ZSWIM8 MYH10 POLG CTSL CTSV	4.49e-04	216	42	5	MP:0004937
MousePheno	abnormal response to novelty	EPHB2 SLC9A9 NOTUM PRKAA2 ATG2B PLXNA4 PRAMEF17 CTSL NSD3	4.51e-04	787	42	9	MP:0003107
MousePheno	impaired balance	FAM20C MYH10 ATP7A SLC12A2	4.64e-04	121	42	4	MP:0001525
MousePheno	abnormal sensory neuron morphology	EPHB2 TYR MYH10 SLC12A2 SH2D3C PLXNA4 GABRA5	4.69e-04	473	42	7	MP:0000965
MousePheno	decreased thyroxine level	CTSL CTSV PRLR	4.75e-04	51	42	3	MP:0005471
MousePheno	globular heart	ZSWIM8 MYH10	4.76e-04	11	42	2	MP:0031511
MousePheno	abnormal copper homeostasis	ATP7A CP	4.76e-04	11	42	2	MP:0003951
MousePheno	abnormal amino acid derivative level	ATP7A CTSL CTSV PRLR	5.24e-04	125	42	4	MP:0021145
MousePheno	abnormal heart size	ZSWIM8 MYH10 POLG ATG2B FGB CP SMARCAD1 PRAMEF17 CTSL CTSV GABRA5	5.48e-04	1180	42	11	MP:0005406
MousePheno	abnormal piliary canal morphology	CTSL CTSV	5.71e-04	12	42	2	MP:0030570
MousePheno	absent coat pigmentation	TYR ATP7A	5.71e-04	12	42	2	MP:0005171
MousePheno	thick epidermis stratum granulosum	CTSL CTSV	5.71e-04	12	42	2	MP:0009599
MousePheno	lymph node inflammation	CTSL CTSV	5.71e-04	12	42	2	MP:0003865
MousePheno	abnormal exploration in a new environment	EPHB2 NOTUM PRKAA2 ATG2B PLXNA4 PRAMEF17 CTSL NSD3	5.89e-04	647	42	8	MP:0013189
MousePheno	abnormal Ammon gyrus morphology	ATP7A SLC9A6 GABRA5	5.94e-04	55	42	3	MP:0000815
MousePheno	abnormal hair cycle	CTSL CTSV PRLR	5.94e-04	55	42	3	MP:0000427
MousePheno	aortic valve regurgitation	CTSL CTSV	6.73e-04	13	42	2	MP:0006047
MousePheno	atrioventricular valve regurgitation	CTSL CTSV	6.73e-04	13	42	2	MP:0006046
MousePheno	abnormal salivary gland physiology	SLC12A2 CTSL CTSV	6.94e-04	58	42	3	MP:0005310
MousePheno	dilated cardiomyopathy	MYH10 CTSL CTSV	7.66e-04	60	42	3	MP:0002795
MousePheno	abnormal learning/memory/conditioning	EPHB2 FAM20C NOTUM PRKAA2 ATG2B PLXNA4 PRAMEF17 CTSL SLC9A6 NSD3 GABRA5	8.27e-04	1239	42	11	MP:0002063
MousePheno	abnormal ear physiology	EPHB2 FAM20C SLC12A2 POLG ATG2B REG1B PRAMEF17 GABRA5	8.48e-04	684	42	8	MP:0003878
MousePheno	abnormal cognition	EPHB2 FAM20C NOTUM PRKAA2 ATG2B PLXNA4 PRAMEF17 CTSL SLC9A6 NSD3 GABRA5	8.66e-04	1246	42	11	MP:0014114
MousePheno	abnormal response to new environment	EPHB2 NOTUM PRKAA2 ATG2B PLXNA4 PRAMEF17 CTSL NSD3	8.73e-04	687	42	8	MP:0001413
MousePheno	abnormal spiral ligament fibrocyte morphology	SLC12A2 GABRA5	9.03e-04	15	42	2	MP:0004292
MousePheno	excessive scratching	CTSL CTSV	9.03e-04	15	42	2	MP:0001412
MousePheno	abnormal somatic sensory system morphology	EPHB2 TYR MYH10 SLC12A2 POLG SH2D3C PLXNA4 GABRA5	1.00e-03	702	42	8	MP:0000959
MousePheno	dilated lateral ventricle	MYH10 CFAP54 SPEF2	1.01e-03	66	42	3	MP:0000825
MousePheno	abnormal thyroxine level	CTSL CTSV PRLR	1.01e-03	66	42	3	MP:0005469
MousePheno	abnormal hair follicle outer root sheath morphology	CTSL CTSV	1.03e-03	16	42	2	MP:0010684
MousePheno	orthokeratosis	CTSL CTSV	1.03e-03	16	42	2	MP:0009675
MousePheno	short hair	CTSL CTSV	1.03e-03	16	42	2	MP:0000417
MousePheno	abnormal testis morphology	FAM20C SLC12A2 POLG RAB11FIP2 SH2D3C PLXNA4 PRAMEF17 CTSL CTSV GABRA5	1.10e-03	1081	42	10	MP:0001146
MousePheno	postnatal lethality	FAM20C MYH10 ATP7A SLC12A2 NOTUM SPEF2 SMARCAD1 CTSL CTSV SLC9A6	1.12e-03	1084	42	10	MP:0002082
MousePheno	abnormal thymus corticomedullary boundary morphology	CTSL CTSV	1.16e-03	17	42	2	MP:0009543
MousePheno	greasy coat	CTSL CTSV	1.16e-03	17	42	2	MP:0003849
MousePheno	abnormal tooth root morphology	FAM20C NOTUM	1.16e-03	17	42	2	MP:0030493
MousePheno	semilunar valve regurgitation	CTSL CTSV	1.31e-03	18	42	2	MP:0006049
MousePheno	abnormal testis size	SLC12A2 POLG RAB11FIP2 SH2D3C PLXNA4 PRAMEF17 CTSL CTSV GABRA5	1.33e-03	915	42	9	MP:0004849
MousePheno	abnormal thyroid hormone level	CTSL CTSV PRLR	1.41e-03	74	42	3	MP:0005468
MousePheno	abnormal external auditory canal morphology	CTSL CTSV	1.46e-03	19	42	2	MP:0006033
MousePheno	abnormal hair follicle orientation	CTSL CTSV	1.46e-03	19	42	2	MP:0000383
MousePheno	delayed hair appearance	CTSL CTSV	1.46e-03	19	42	2	MP:0000422
MousePheno	macrocytic anemia	SF3B1 POLG	1.46e-03	19	42	2	MP:0002811
MousePheno	abnormal hair shaft morphology	ATP7A CTSL CTSV	1.47e-03	75	42	3	MP:0003809
MousePheno	short vibrissae	CTSL CTSV	1.62e-03	20	42	2	MP:0001282
MousePheno	chronic inflammation	NOTUM CTSL CTSV	1.70e-03	79	42	3	MP:0002499
Domain	Na/H_exchanger_6	SLC9A9 SLC9A6	2.74e-05	3	57	2	IPR002090
Domain	Inhibitor_I29	CTSL CTSV	1.90e-04	7	57	2	PF08246
Domain	Prot_inhib_I29	CTSL CTSV	1.90e-04	7	57	2	IPR013201
Domain	Inhibitor_I29	CTSL CTSV	1.90e-04	7	57	2	SM00848
Domain	NaH_exchanger	SLC9A9 SLC9A6	3.25e-04	9	57	2	IPR004709
Domain	Pept_asp_AS	CTSL CTSV	4.05e-04	10	57	2	IPR025661
Domain	Pept_his_AS	CTSL CTSV	4.94e-04	11	57	2	IPR025660
Domain	Cation/H_exchanger_CPA1	SLC9A9 SLC9A6	4.94e-04	11	57	2	IPR018422
Domain	Pept_C1	CTSL CTSV	6.99e-04	13	57	2	SM00645
Domain	Peptidase_C1A_C	CTSL CTSV	6.99e-04	13	57	2	IPR000668
Domain	Peptidase_C1	CTSL CTSV	6.99e-04	13	57	2	PF00112
Domain	Peptidase_C1A	CTSL CTSV	6.99e-04	13	57	2	IPR013128
Domain	Na_H_Exchanger	SLC9A9 SLC9A6	8.13e-04	14	57	2	PF00999
Domain	Cation/H_exchanger	SLC9A9 SLC9A6	8.13e-04	14	57	2	IPR006153
Domain	RASGEF	SH2D3C RASGEF1B	2.84e-03	26	57	2	PS00720
Domain	THIOL_PROTEASE_CYS	CTSL CTSV	2.84e-03	26	57	2	PS00139
Domain	THIOL_PROTEASE_ASN	CTSL CTSV	3.06e-03	27	57	2	PS00640
Domain	THIOL_PROTEASE_HIS	CTSL CTSV	3.06e-03	27	57	2	PS00639
Domain	Pept_cys_AS	CTSL CTSV	3.29e-03	28	57	2	IPR000169
Domain	RASGEF_CAT	SH2D3C RASGEF1B	3.52e-03	29	57	2	PS50009
Domain	RasGEF	SH2D3C RASGEF1B	3.77e-03	30	57	2	PF00617
Domain	-	SH2D3C RASGEF1B	3.77e-03	30	57	2	1.10.840.10
Domain	Ras_GEF_dom	SH2D3C RASGEF1B	3.77e-03	30	57	2	IPR023578
Domain	RASGEF_cat_dom	SH2D3C RASGEF1B	3.77e-03	30	57	2	IPR001895
Domain	RasGEF	SH2D3C RASGEF1B	3.77e-03	30	57	2	SM00147
Pubmed	Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions.	CTSL CTSV	2.83e-06	2	59	2	19801522
Pubmed	Genes for endosomal pH regulators NHE6 and NHE9 are dysregulated in the substantia nigra in Parkinson's disease.	SLC9A9 SLC9A6	2.83e-06	2	59	2	38945311
Pubmed	Identification of procathepsin L (pCTS-L)-neutralizing monoclonal antibodies to treat potentially lethal sepsis.	CTSL CTSV	2.83e-06	2	59	2	36735789
Pubmed	Cathepsin L plays an active role in involution of the mouse mammary gland.	CTSL CTSV	2.83e-06	2	59	2	12815617
Pubmed	Cathepsin L promotes Vascular Intimal Hyperplasia after Arterial Injury.	CTSL CTSV	2.83e-06	2	59	2	28332696
Pubmed	Impaired turnover of autophagolysosomes in cathepsin L deficiency.	CTSL CTSV	2.83e-06	2	59	2	20536383
Pubmed	Response to comment on "Cathepsin-L influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number".	CTSL CTSV	2.83e-06	2	59	2	16621972
Pubmed	Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis.	CTSL CTSV	2.83e-06	2	59	2	33540247
Pubmed	The protease cathepsin L regulates Th17 cell differentiation.	CTSL CTSV	2.83e-06	2	59	2	26343333
Pubmed	Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice.	CTSL CTSV	2.83e-06	2	59	2	16636100
Pubmed	Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation.	CTSL CTSV	2.83e-06	2	59	2	31010818
Pubmed	Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages.	CTSL CTSV	2.83e-06	2	59	2	20338168
Pubmed	A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A.	EPHB2 SH2D3C	2.83e-06	2	59	2	10542222
Pubmed	Cathepsin L coexists with Cytotoxic T-lymphocyte Antigen-2 alpha in distinct regions of the mouse brain.	CTSL CTSV	2.83e-06	2	59	2	27586811
Pubmed	Autophagy and cathepsin L are involved in the antinociceptive effect of DMBC in a mouse acetic acid-writhing model.	CTSL CTSV	2.83e-06	2	59	2	23912553
Pubmed	Cathepsin L Helps to Defend Mice from Infection with Influenza A.	CTSL CTSV	2.83e-06	2	59	2	27716790
Pubmed	The radiation-induced nackt (nkt) allele is a loss-of-function mutation of the mouse cathepsin L gene.	CTSL CTSV	2.83e-06	2	59	2	16393949
Pubmed	Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization.	CTSL CTSV	2.83e-06	2	59	2	20304958
Pubmed	Characterization and comparative mapping of the porcine CTSL gene indicates a novel synteny between HSA9q21-->q22 and SSC10q11-->q12.	CTSL CTSV	2.83e-06	2	59	2	11978977
Pubmed	Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels.	CTSL CTSV	2.83e-06	2	59	2	2275556
Pubmed	The CD4 T cell-deficient mouse mutation nackt (nkt) involves a deletion in the cathepsin L (CtsI) gene.	CTSL CTSV	2.83e-06	2	59	2	11398968
Pubmed	A variant of pulmonary alveolar microlithiasis in nackt mice.	CTSL CTSV	2.83e-06	2	59	2	12014504
Pubmed	Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis.	CTSL CTSV	2.83e-06	2	59	2	23600672
Pubmed	Mice that express enzymatically inactive cathepsin L exhibit abnormal spermatogenesis.	CTSL CTSV	2.83e-06	2	59	2	12533435
Pubmed	Cathepsin L was involved in vascular aging by mediating phenotypic transformation of vascular cells.	CTSL CTSV	2.83e-06	2	59	2	36206719
Pubmed	Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice.	CTSL CTSV	2.83e-06	2	59	2	12466121
Pubmed	Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin.	CTSL CTSV	2.83e-06	2	59	2	3689328
Pubmed	Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly.	CTSL CTSV	2.83e-06	2	59	2	10516062
Pubmed	Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling.	CTSL CTSV	2.83e-06	2	59	2	19096818
Pubmed	Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling.	CTSL CTSV	2.83e-06	2	59	2	11023992
Pubmed	Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease.	CTSL CTSV	2.83e-06	2	59	2	17671649
Pubmed	Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins.	CTSL CTSV	2.83e-06	2	59	2	3755373
Pubmed	[Effect of bushen tiaojing recipe and xiaoyao pill on expression of cathepsin-L mRNA in gonadotropin-primed mice].	CTSL CTSV	2.83e-06	2	59	2	21434350
Pubmed	Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts.	CTSL CTSV	2.83e-06	2	59	2	21972973
Pubmed	Cell type-specific functions of the lysosomal protease cathepsin L in the heart.	CTSL CTSV	2.83e-06	2	59	2	17942402
Pubmed	Genes for endosomal NHE6 and NHE9 are misregulated in autism brains.	SLC9A9 SLC9A6	2.83e-06	2	59	2	23508127
Pubmed	Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin.	CTSL CTSV	2.83e-06	2	59	2	16705169
Pubmed	The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles.	CTSL CTSV	2.83e-06	2	59	2	15679121
Pubmed	Interaction of ceruloplasmin and 5-lipoxygenase.	CP ALOX5	2.83e-06	2	59	2	21314617
Pubmed	Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts.	CTSL CTSV	2.83e-06	2	59	2	2835398
Pubmed	Identification on melanoma cells of p39, a cysteine proteinase that cleaves C3, the third component of complement: amino-acid-sequence identities with procathepsin L.	CTSL CTSV	2.83e-06	2	59	2	8554545
Pubmed	Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies.	CTSL CTSV	2.83e-06	2	59	2	19589362
Pubmed	Cathepsin L is essential for onset of autoimmune diabetes in NOD mice.	CTSL CTSV	2.83e-06	2	59	2	16184198
Pubmed	The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling.	CTSL CTSV	2.83e-06	2	59	2	16079282
Pubmed	Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice.	CTSL CTSV	2.83e-06	2	59	2	21868704
Pubmed	Cathepsin-L contributes to cardiac repair and remodelling post-infarction.	CTSL CTSV	2.83e-06	2	59	2	21147810
Pubmed	Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation.	CTSL CTSV	2.83e-06	2	59	2	18957203
Pubmed	Identification of a membrane-associated cysteine protease with possible dual roles in the endoplasmic reticulum and protein storage vacuole.	CTSL CTSV	2.83e-06	2	59	2	11022031
Pubmed	B-cell lymphopoiesis is regulated by cathepsin L.	CTSL CTSV	2.83e-06	2	59	2	23585893
Pubmed	Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.	CTSL CTSV	2.83e-06	2	59	2	9545226
Pubmed	Cathepsin L gene expression and promoter activation in rodent granulosa cells.	CTSL CTSV	2.83e-06	2	59	2	14563703
Pubmed	Cathepsin L is crucial for the development of early experimental diabetic nephropathy.	CTSL CTSV	2.83e-06	2	59	2	27575559
Pubmed	Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.	CTSL CTSV	2.83e-06	2	59	2	11972068
Pubmed	Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity.	CTSL CTSV	2.83e-06	2	59	2	20877570
Pubmed	Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.	CTSL CTSV	2.83e-06	2	59	2	19900452
Pubmed	Evidence for a critical role of ceruloplasmin oxidase activity in iron metabolism of Wilson disease gene knockout mice.	ATP7A CP	2.83e-06	2	59	2	20594231
Pubmed	Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression.	CTSL CTSV	2.83e-06	2	59	2	25957406
Pubmed	Cloning, genomic organization, and chromosomal localization of human cathepsin L.	CTSL CTSV	2.83e-06	2	59	2	8419312
Pubmed	Thymocyte expression of cathepsin L is essential for NKT cell development.	CTSL CTSV	2.83e-06	2	59	2	12368909
Pubmed	Cloning and characterization of a mouse cysteine proteinase.	CTSL CTSV	2.83e-06	2	59	2	3533924
Pubmed	Surface activation of pro-cathepsin L.	CTSL CTSV	2.83e-06	2	59	2	1482371
Pubmed	Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation.	CTSL CTSV	2.83e-06	2	59	2	12163394
Pubmed	Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice.	CTSL CTSV	2.83e-06	2	59	2	20347002
Pubmed	Cathepsin L-deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy.	CTSL CTSV	2.83e-06	2	59	2	15154914
Pubmed	Cathepsin-L ameliorates cardiac hypertrophy through activation of the autophagy-lysosomal dependent protein processing pathways.	CTSL CTSV	2.83e-06	2	59	2	23608608
Pubmed	Developmental expression of cathepsin L and c-rasHa in the mouse placenta.	CTSL CTSV	2.83e-06	2	59	2	1751032
Pubmed	Inhibition of cathepsin L alleviates the microglia-mediated neuroinflammatory responses through caspase-8 and NF-κB pathways.	CTSL CTSV	2.83e-06	2	59	2	29154036
Pubmed	Peripheral cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin synthesis.	CTSL CTSV	2.83e-06	2	59	2	31771567
Pubmed	The Menkes copper transporter is required for the activation of tyrosinase.	TYR ATP7A	2.83e-06	2	59	2	11092760
Pubmed	Evolution of placentally expressed cathepsins.	CTSL CTSV	2.83e-06	2	59	2	12054558
Pubmed	Cathepsin L is involved in proliferation and invasion of breast cancer cells.	CTSL CTSV	2.83e-06	2	59	2	26639231
Pubmed	An alternate targeting pathway for procathepsin L in mouse fibroblasts.	CTSL CTSV	2.83e-06	2	59	2	11929604
Pubmed	Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis.	CTSL CTSV	2.83e-06	2	59	2	20023699
Pubmed	Vestibular hair bundles control pH with (Na+, K+)/H+ exchangers NHE6 and NHE9.	SLC9A9 SLC9A6	2.83e-06	2	59	2	17005858
Pubmed	Impaired cathepsin L gene expression in skeletal muscle is associated with type 2 diabetes.	CTSL CTSV	2.83e-06	2	59	2	12941783
Pubmed	The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling.	CTSL CTSV	2.83e-06	2	59	2	12000732
Pubmed	Cathepsin-L influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number.	CTSL CTSV	2.83e-06	2	59	2	15905545
Pubmed	[Identification of a fragment of ceruloplasmin, interacting with copper-transporting Menkes ATPase].	ATP7A CP	2.83e-06	2	59	2	11040994
Pubmed	Alterations during positive selection in the thymus of nackt CD4-deficient mice.	CTSL CTSV	2.83e-06	2	59	2	11119260
Pubmed	Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels.	CTSL CTSV	2.83e-06	2	59	2	18469859
Pubmed	Cortical Thymocytes Along With Their Selecting Ligands Are Required for the Further Thymic Maturation of NKT Cells in Mice.	CTSL CTSV	2.83e-06	2	59	2	32457751
Pubmed	Cloning and expression of the gene for the major excreted protein of transformed mouse fibroblasts. A secreted lysosomal protease regulated by transformation.	CTSL CTSV	2.83e-06	2	59	2	2826441
Pubmed	Inhibition of cysteine protease cathepsin L increases the level and activity of lysosomal glucocerebrosidase.	CTSL CTSV	2.83e-06	2	59	2	38329128
Pubmed	Inhibitory fragment from the p41 form of invariant chain can regulate activity of cysteine cathepsins in antigen presentation.	CTSL CTSV	8.48e-06	3	59	2	18362148
Pubmed	The PI3K regulatory subunits p55α and p50α regulate cell death in vivo.	CTSL CTSV	8.48e-06	3	59	2	24902901
Pubmed	Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome.	CTSL CTSV	8.48e-06	3	59	2	23233448
Pubmed	Cathepsin L activity controls adipogenesis and glucose tolerance.	CTSL CTSV	8.48e-06	3	59	2	17643114
Pubmed	Invariant chain controls the activity of extracellular cathepsin L.	CTSL CTSV	8.48e-06	3	59	2	12417635
Pubmed	Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression.	CTSL CTSV	8.48e-06	3	59	2	32707827
Pubmed	Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis.	CTSL CTSV	8.48e-06	3	59	2	23811845
Pubmed	Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion.	CTSL CTSV	8.48e-06	3	59	2	28759565
Pubmed	Expression levels of cathepsin L and cystatin C in a hyperglycemic environment were associated with aortic aneurysm development in a mouse model.	CTSL CTSV	8.48e-06	3	59	2	31096818
Pubmed	Protective role of cathepsin L in mouse skin carcinogenesis.	CTSL CTSV	8.48e-06	3	59	2	21538579
Pubmed	Expression of the human Cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis.	CTSL CTSV	8.48e-06	3	59	2	17697143
Pubmed	Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin.	CTSL CTSV	8.48e-06	3	59	2	15197181
Pubmed	Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis.	CTSL CTSV	8.48e-06	3	59	2	12809493
Pubmed	Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection.	CTSL CTSV	8.48e-06	3	59	2	15831716
Pubmed	Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia.	CTSL CTSV	8.48e-06	3	59	2	17622569
Pubmed	Induction of cytotoxic T-lymphocyte antigen-2beta, a cysteine protease inhibitor in decidua: a potential regulator of embryo implantation.	CTSL CTSV	8.48e-06	3	59	2	14681235
Pubmed	Proteolytic cleavage of the disease-related lysosomal membrane glycoprotein CLN7.	CTSL CTSV	8.48e-06	3	59	2	22668694
Interaction	CTSL3P interactions	CTSL3P CTSL	7.31e-06	2	55	2	int:CTSL3P
Cytoband	11p15.4	OR51M1 OR52N2 OR52E4 OR52P1	1.32e-04	200	59	4	11p15.4
Cytoband	9q21.33	CTSL3P CTSL	2.45e-04	18	59	2	9q21.33
Cytoband	5p13.2	SPEF2 PRLR	7.37e-04	31	59	2	5p13.2
GeneFamily	Olfactory receptors, family 52	OR52N2 OR52E4 OR52P1	1.85e-04	49	41	3	165
GeneFamily	Cathepsins	CTSL CTSV	5.17e-04	15	41	2	470
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	HEATR1 SP110	5.96e-03	51	41	2	870
Coexpression	CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP	UGT1A3 SLC12A2 UBA2 CTSL CTSV	1.08e-05	136	56	5	MM464
Coexpression	NABA_MATRISOME_HYPERPLASTIC_PANCREATIC_ISLETS	REG1B CTSL CTSV	2.32e-05	26	56	3	MM17051
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC9A9 ADGRB3 CP ADCY2 ALOX5	3.55e-06	175	59	5	f24b664b9056b5976bf2222e8013f15c09e049ad
ToppCell	E15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLC9A9 ATP7A SLC12A2 CYP20A1 SH2D3C	5.30e-06	190	59	5	84fbd5664ec886120963d4f50dfa1fd1851d36c1
ToppCell	droplet-Pancreas-Endocrine-21m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM20C CAD SF3B1 GMPR PRLR	5.87e-06	194	59	5	3a3ecedcdc7691cf21775818b598208fcb980c29
ToppCell	Tracheal\|World / Cell types per location group and 10X technology with lineage, and cell group designations	SLC12A2 PRKAA2 ADGRB3 CP ADCY2	6.80e-06	200	59	5	682960e28542a3d6c119047cd0131941932cfdea
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	RASGEF1B SLC35B2 CTSL ALOX5	4.22e-05	146	59	4	a317f14a1aab11ffcce65baeb1c475c04324315f
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P1\|Thalamus / BrainAtlas - Mouse McCarroll V32	SLC12A2 SLC35B2 CTSL ALOX5	4.33e-05	147	59	4	a21b63d0d3aec9ffadf3fac833a0a24da58a95bf
ToppCell	Adult-Epithelial-basal_cell-D122\|Adult / Lineage, Cell type, age group and donor	CP NYAP1 ADCY2 GABRA5	5.19e-05	154	59	4	38d346402417960044ae999e61f0092b46f2b591
ToppCell	343B-Myeloid-Dendritic-pDC\|343B / Donor, Lineage, Cell class and subclass (all cells)	RASGEF1B PLXNA4 BCL11A CTSV	5.46e-05	156	59	4	547e2debfc09c07c049a880dded5fda7dd53e156
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC9A9 SLC12A2 WDR7 SLC9A6	5.46e-05	156	59	4	d411116d54add2d4fe649a97ac54cb94c085312f
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE\|Thalamus / BrainAtlas - Mouse McCarroll V32	SLC12A2 SLC35B2 CTSL ALOX5	7.11e-05	167	59	4	1e144c03409df94ccd39760842590e8ea7487e29
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.4\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC12A2 PRKAA2 CP CTSV	8.15e-05	173	59	4	176b956e71d98e8275d698b39437fc326e5fe449
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	RASGEF1B BCL11A SP110 ALOX5	8.15e-05	173	59	4	d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB2 GMPR ECT2L GSG1	8.33e-05	174	59	4	b2fc2a756f8e373ad903bd416d9de703d945fa1c
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A2 ADGRB3 FGB PRLR	8.52e-05	175	59	4	0992de1c7bffcb6890584357a7a0a8955927da6c
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB2 SLC9A9 BCL11A CTSL	8.71e-05	176	59	4	d4075796c38b775fe721abb47426e662a0d415e3
ToppCell	Ciliated_cells-B-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	CFAP54 SPEF2 UBA2 ECT2L	9.50e-05	180	59	4	bdea5ec6b60fc8c7cce4d71db5da74ac8675e211
ToppCell	15-Airway-Epithelial-Submucosal_gland\|Airway / Age, Tissue, Lineage and Cell class	SLC12A2 CP BCL11A PRLR	9.50e-05	180	59	4	283bb0d58811947bfda4e286b9ec87d869c8e29e
ToppCell	Adult-Epithelial-ciliated_cell-D122\|Adult / Lineage, Cell type, age group and donor	TYR CFAP54 SPEF2 ECT2L	9.91e-05	182	59	4	7ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D175\|Adult / Lineage, Cell type, age group and donor	EPHB2 FAM20C SLC9A9 CTSL	1.06e-04	185	59	4	ab5704b96f1d368911308797d10c7c52766ab134
ToppCell	RV-07._Pericyte\|RV / Chamber and Cluster_Paper	SLC12A2 SH2D3C ADGRB3 UBA2	1.08e-04	186	59	4	c533b264fbe12bc35467486fc7fbde24ba968fe1
ToppCell	Ciliated_cells-B-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	CFAP54 SPEF2 CP ECT2L	1.10e-04	187	59	4	6fa38dbccca36bc7a4fef46de74c6688f599f421
ToppCell	normal_Lung-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	PLXNA4 HEATR1 BCL11A CTSV	1.10e-04	187	59	4	a3592f056e1c2f82ba325fea2ecc4dd6c6347c81
ToppCell	RV-07._Pericyte\|World / Chamber and Cluster_Paper	SLC12A2 SH2D3C ADGRB3 UBA2	1.10e-04	187	59	4	dc274d6bbda619a2c914d84e2b4069cfef1739d1
ToppCell	normal_Lung-Myeloid_cells-pDCs\|normal_Lung / Location, Cell class and cell subclass	PLXNA4 HEATR1 BCL11A CTSV	1.10e-04	187	59	4	d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	PRKAA2 GMPR ECT2L BCL11A	1.10e-04	187	59	4	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Ciliated_1\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	CFAP54 SPEF2 CP ECT2L	1.15e-04	189	59	4	dc440015949a768188c67661b6be63b1ead1a0f0
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_1\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	NOTUM PLXNA4 GMPR SLC9A6	1.17e-04	190	59	4	71a00f63fdd4eb4cc6f190d37e7a0417cdaafacb
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC9A9 MYH10 ADGRB3 PLXNA4	1.19e-04	191	59	4	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	(011)_pDC\|World / immune cells in Peripheral Blood (logTPM normalization)	ADGRB3 PLXNA4 BCL11A CTSV	1.19e-04	191	59	4	d82ac4f6d9863734e09bf3cb71c1354a49b66b4f
ToppCell	18-Airway-Mesenchymal-Airway_Smooth_Muscle\|Airway / Age, Tissue, Lineage and Cell class	NOTUM PLXNA4 GMPR SLC9A6	1.19e-04	191	59	4	86ce98d2c90c196474b06869de888cf5d1eed196
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC9A9 MYH10 ADGRB3 PLXNA4	1.22e-04	192	59	4	6f4ef24dab544681304b7f8a9dc073e7edaa4cf5
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM20C CAD GMPR PRLR	1.24e-04	193	59	4	471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC9A9 MYH10 ADGRB3 PLXNA4	1.24e-04	193	59	4	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM20C CAD GMPR PRLR	1.24e-04	193	59	4	fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC9A9 MYH10 ADGRB3 PLXNA4	1.27e-04	194	59	4	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC9A9 MYH10 ADGRB3 PLXNA4	1.27e-04	194	59	4	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM20C CAD GMPR PRLR	1.27e-04	194	59	4	0b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAM20C RASGEF1B CTSL ALOX5	1.29e-04	195	59	4	9d649ac7d2af313481069c95349efc0c68449e2b
ToppCell	distal-Epithelial-Differentiating_Basal-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	EPHB2 CP BCL11A GABRA5	1.29e-04	195	59	4	3fe6e49a9161fc9e5160251e6932cb5378175a54
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP54 SPEF2 CP ECT2L	1.29e-04	195	59	4	9651ee03738226ee10e901f8b9ec6a417eb9c301
ToppCell	11.5-Distal-Mesenchymal-Airway_Smooth_Muscle\|Distal / Age, Tissue, Lineage and Cell class	NOTUM PLXNA4 BCL11A SLC9A6	1.32e-04	196	59	4	05530fe7a5681c2f39b95016cd22ef99d6ac0430
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC12A2 PRKAA2 CP ADCY2	1.32e-04	196	59	4	020110cd79453df9546fb20802fe38ecadd9fe74
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM1\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	EPHB2 FAM20C CTSL PRLR	1.32e-04	196	59	4	7c8aa5853d7096628e35af665097c0299c329753
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM1-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EPHB2 FAM20C CTSL PRLR	1.32e-04	196	59	4	f60b220ed117bcc33e0f7bbf5b53d3b1422ebaca
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM1-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	EPHB2 FAM20C CTSL PRLR	1.32e-04	196	59	4	bcd274db4955ea76ca26267a272c7d1929db24f4
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EPHB2 FAM20C CTSL PRLR	1.32e-04	196	59	4	80b9139d91dda4de69830d2d443859e047ab5503
ToppCell	Mild_COVID-19-Myeloid-MoAM1\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	EPHB2 FAM20C CTSL PRLR	1.32e-04	196	59	4	ea3fbe81b4ecb6ccc8031f6d99da93c9f9f8c1aa
ToppCell	BAL-Mild-Myeloid-MoAM\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EPHB2 FAM20C CTSL PRLR	1.34e-04	197	59	4	0f40dd3530eb8d02e79b32f942efe3b65b8f6ee6
ToppCell	BAL-Mild-Myeloid-MoAM\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	EPHB2 FAM20C CTSL PRLR	1.34e-04	197	59	4	a6aa5991d566c28440f7e24a30933e69669064f2
ToppCell	5'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHB2 SLC12A2 BCL11A PRLR	1.40e-04	199	59	4	f544229f471b4717166dd4b588399afe45cc31b5
ToppCell	BAL-Mild-cDC_1\|Mild / Compartment, Disease Groups and Clusters	RASGEF1B GMPR SP110 CTSL	1.40e-04	199	59	4	c55181bdec8952b54198f0d4c9c5c84265b16572
ToppCell	background\|World / Sample and Cell Type and Tumor Cluster (all cells)	RASGEF1B FGB CP CTSL	1.40e-04	199	59	4	5a6d0e00bfe1351eea192b54020bedeef78854e9
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CP BCL11A GSG1 GABRA5	1.40e-04	199	59	4	e9c47f565a0a7737ecff68569d668aeb707ae5a6
ToppCell	LPS_IL1RA-Epithelial_airway-airway_epithelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CFAP54 CP CTSV ADCY2	1.42e-04	200	59	4	cf191104484bfb2b9f87de416b9453135f8833c1
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CFAP54 CP CTSV ADCY2	1.42e-04	200	59	4	da12821e8a0657869ca0f75d351cce2d7605a505
ToppCell	LPS_IL1RA-Epithelial_airway\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CFAP54 CP CTSV ADCY2	1.42e-04	200	59	4	a5ae33dd4dc1ff6e1a1eec22c4d523d5ab657607
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Mesenchymal\|3m / Sample Type, Dataset, Time_group, and Cell type.	TYR SPEF2 CP GMPR	1.42e-04	200	59	4	ce012d738cbec1afdd6af0e10e94b2b6c17b036e
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Mesenchymal-BMP_responsible_cell\|3m / Sample Type, Dataset, Time_group, and Cell type.	TYR SPEF2 CP GMPR	1.42e-04	200	59	4	a4b52466b6426a835655b5fe7487e15aea816e14
ToppCell	mLN-Dendritic_cell-pDC\|Dendritic_cell / Region, Cell class and subclass	ATG2B PLXNA4 SMARCAD1 BCL11A	1.42e-04	200	59	4	10ae1ac8a98346320a92e855aebb3a7109f0ab9b
ToppCell	LPS_IL1RA_TNF-Epithelial_airway\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CFAP54 CP CTSV ADCY2	1.42e-04	200	59	4	72c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf-Oligodendrocyte.Tfr.Tmem2_(Tmem2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SPEF2 CTSL ALOX5	3.45e-04	103	59	3	287e945ef2f9646f1ff4a4c50fe6e8a5e7fe0d92
ToppCell	(09)_Ionocytes-(3)_72hpi\|(09)_Ionocytes / shred by cell type and Timepoint	FAM20C POLG ALOX5	4.18e-04	110	59	3	fce7d5a0617fc664b657f5bb9abb290e7cc234cb
ToppCell	COVID-19-kidney-Epithelial_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	SLC9A9 BCL11A ALOX5	5.39e-04	120	59	3	e17c85d41c781a29dec7e03a8b0637dccb4346bc
ToppCell	Cerebellum-Macroglia-POLYDENDROCYTE-P1-P1_1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	RASGEF1B CTSL ALOX5	5.80e-04	123	59	3	e0eb95f1da12687230b47f0a7367b6138bc7ff1a
ToppCell	Cerebellum-Macroglia-POLYDENDROCYTE-P1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	RASGEF1B CTSL ALOX5	5.80e-04	123	59	3	356e2b1b47fdfc2bb2fcd45e44b452fe811f0fd8
ToppCell	Cerebellum-Macroglia-POLYDENDROCYTE-P1-P1_1-Polydendrocyte.Tnr.Tnr_(Tnr)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	RASGEF1B CTSL ALOX5	5.80e-04	123	59	3	b06a38d1081b4485b519853d8c9a2cddfb1e9e75
ToppCell	Cerebellum-Macroglia-POLYDENDROCYTE-P1-P1_1-Polydendrocyte.Tnr.Tnr_(Tnr)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	RASGEF1B CTSL ALOX5	5.80e-04	123	59	3	f60c1dd89da0e204f73772fe0c319eeca82e7e8a
ToppCell	Cerebellum-Macroglia-POLYDENDROCYTE\|Cerebellum / BrainAtlas - Mouse McCarroll V32	RASGEF1B CTSL ALOX5	5.80e-04	123	59	3	15f951b4eb2f39888e51e1af18c329953d253f7f
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9\|TCGA-Bladder / Sample_Type by Project: Shred V9	CP RFX7 NSD3	7.12e-04	132	59	3	48449e2e95804a26f204ac7ea763dee26cf794ab
ToppCell	RV-14._Fibroblast_III\|World / Chamber and Cluster_Paper	SLC9A9 ADGRB3 GSG1	7.43e-04	134	59	3	8c4046ba1f85172915a112499e492c3efe8474c2
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRB3 PLXNA4 BCL11A	7.43e-04	134	59	3	0e3f37ef041b751ed45060b5ce39385a2731370b
ToppCell	(09)_Ionocytes\|World / shred by cell type and Timepoint	ATP7A SLC12A2 PLXNA4	7.60e-04	135	59	3	237b9b646513ca6e4b754c0da95d24015b3661f7
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SLC12A2 CTSL ALOX5	7.93e-04	137	59	3	80f1a6cfb48ccfba1c3545fdcd5fcb3157272aca
ToppCell	RV-14._Fibroblast_III\|RV / Chamber and Cluster_Paper	SLC9A9 ADGRB3 GSG1	8.44e-04	140	59	3	b4fee8eb6bf855b364b00bda3f78e49d851bbca0
ToppCell	Goblet-gob-2\|World / Class top	SLC12A2 BCL11A ADCY2	8.79e-04	142	59	3	9b058dc313d1f0edcd8473e342852632e17536a6
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-Monocytes-Macrophages\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPHB2 SLC9A9 RASGEF1B	9.53e-04	146	59	3	b76110b159acd27a2c8d6a9f98336608ace1ec12
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Cortical_neuron\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	PLXNA4 SMARCAD1 BCL11A	9.91e-04	148	59	3	a1269312903fc27830c1835dabf660c659a711be
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SLC35B2 CTSL ALOX5	1.03e-03	150	59	3	70ac8ae4b1683fb17278a8e4606f2fa0b94988c0
ToppCell	droplet-Liver-nan-3m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGB CP PRLR	1.05e-03	151	59	3	cc9632b58522e2ba3ad36a0b8d37c7c9c8b636c4
ToppCell	droplet-Liver-nan-3m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGB CP PRLR	1.05e-03	151	59	3	7758cfbe8dca849c90bd6e8bc63310e53beeb8fd
ToppCell	droplet-Liver-nan-3m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGB CP PRLR	1.05e-03	151	59	3	b4a0546c1573b4b2290890307f2a5daf3a7cbb37
ToppCell	droplet-Bladder-nan-3m-Hematologic-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXNA4 ALOX5 GSG1	1.05e-03	151	59	3	a7b1a60d68f0ed17022fe4c97af64f9f08d39fa3
ToppCell	droplet-Liver-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGB CP PRLR	1.07e-03	152	59	3	1febeeb7376e34b9f86c81b2cb1314ee12408864
ToppCell	droplet-Liver-nan-3m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGB CP PRLR	1.07e-03	152	59	3	faa92f7c5a6db9f1eb7d8ec930ba7c8ed9fd1bf1
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PRKAA2 CP ADCY2	1.07e-03	152	59	3	1b2a39ae159e79f1fb18d6d164bd7acab5299fca
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage\|368C / Donor, Lineage, Cell class and subclass (all cells)	TAS2R30 CTSL ALOX5	1.09e-03	153	59	3	e0fbbfd4d13031412e0b985322c8b99c56eb7af5
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZSWIM8 SLC12A2 CTSV	1.11e-03	154	59	3	ba55a63cfa5e0fb9dfec794f80078a2f0d03d0ad
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP54 ATP7A GMPR	1.13e-03	155	59	3	441fcb6d05364fc6f4973f0b973f1a80b573ce1f
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CP NYAP1 ADCY2	1.17e-03	157	59	3	c43f2e1ea53b375a7432f17f87cfef3b2261003d
ToppCell	droplet-Liver-nan-3m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGB CP PRLR	1.17e-03	157	59	3	b72c6a1ed17bfc32d9dec193d934ea82e80b6bd5
ToppCell	Control-Epithelial_airway\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CP CTSV ADCY2	1.20e-03	158	59	3	35aee1c3b92169e73569331022833cb44ab7e7e8
ToppCell	droplet-Heart-nan-24m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZSWIM8 FAM20C CP	1.22e-03	159	59	3	7ad3a91d29639b32f6264c91f401c14a35469ac0
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-7\|TCGA-Liver / Sample_Type by Project: Shred V9	EPHB2 UGT1A3 NOTUM	1.22e-03	159	59	3	70288df54adab167c0f50675128619299077db11
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGB CP PRLR	1.24e-03	160	59	3	8de1fc75241d9bf2b355afa0e9ef39fea1977177
ToppCell	mild-Myeloid-CD14_Monocytes_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	EPHB2 GMPR CTSL	1.24e-03	160	59	3	a83568cd8a0b05642bacd43a8ec443e5ce314c4d
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGB CP PRLR	1.26e-03	161	59	3	274838cebdc7af1db32d309dfe42ef7ccd3c190b
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Epithelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOTUM FGB BCL11A	1.26e-03	161	59	3	b9a63fc9becc44d305fc7c221283bf59ec06b10f
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ATP7A ZNF790 CP	1.26e-03	161	59	3	5fba13f0aa5002f7eefe219e2c6a07e163f1a50d
ToppCell	normal_Lymph_Node-B_lymphocytes-Undetermined\|normal_Lymph_Node / Location, Cell class and cell subclass	OR52N2 BCL11A NSD3	1.28e-03	162	59	3	91ac35ae7fde411cd6a44e715a33dac62419cab8
ToppCell	droplet-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGB CP PRLR	1.31e-03	163	59	3	a794540f2d8984f963c08f05175e4bc916fcc224
Drug	AC1Q5IY7	TYR CP PRLR	4.90e-07	7	56	3	CID000161776
Drug	bicarbonate	EPHB2 SLC9A9 CAD SLC12A2 ADCY2 SLC9A6 PRLR	1.44e-05	325	56	7	CID000000767
Drug	AC1LA3FP	TYR CP	1.78e-05	3	56	2	CID000480798
Drug	6-hydroxykaempferol	TYR ALOX5	1.78e-05	3	56	2	CID005281638
Disease	hepatocellular carcinoma (implicated_via_orthology)	CAD POLG CTSL CTSV	1.71e-06	49	52	4	DOID:684 (implicated_via_orthology)
Disease	Menkes Kinky Hair Syndrome	ATP7A CP	3.05e-06	2	52	2	C0022716
Disease	Wilson disease (biomarker_via_orthology)	ATP7A CP	9.13e-06	3	52	2	DOID:893 (biomarker_via_orthology)
Disease	hyperthyroidism (biomarker_via_orthology)	CP CTSL CTSV	1.64e-05	28	52	3	DOID:7998 (biomarker_via_orthology)
Disease	pancreatitis (biomarker_via_orthology)	FGB CTSL CTSV	4.51e-05	39	52	3	DOID:4989 (biomarker_via_orthology)
Disease	epilepsy (is_implicated_in)	POLG CP	1.09e-04	9	52	2	DOID:1826 (is_implicated_in)
Disease	hair colour measurement, eye colour measurement, skin pigmentation measurement	TYR RAB11FIP2	1.36e-04	10	52	2	EFO_0007009, EFO_0007822, EFO_0009764
Disease	Prostate cancer, familial	EPHB2 RFX7 ELAC2	2.49e-04	69	52	3	C2931456
Disease	myelodysplastic syndrome (implicated_via_orthology)	SF3B1 POLG	3.15e-04	15	52	2	DOID:0050908 (implicated_via_orthology)
Disease	Tremor, Rubral	ATP7A CP	3.60e-04	16	52	2	C0750940
Disease	Ataxia, Appendicular	ATP7A CP	3.60e-04	16	52	2	C0750937
Disease	Ataxia, Motor	ATP7A CP	3.60e-04	16	52	2	C0278161
Disease	Abnormal coordination	ATP7A CP	3.60e-04	16	52	2	C0520966
Disease	Ataxia, Truncal	ATP7A CP	3.60e-04	16	52	2	C0427190
Disease	Ataxia, Sensory	ATP7A CP	3.60e-04	16	52	2	C0240991
Disease	otitis media (biomarker_via_orthology)	CTSL CTSV	4.07e-04	17	52	2	DOID:10754 (biomarker_via_orthology)
Disease	diet measurement, HOMA-B	RAB11FIP2 PLXNA4	5.11e-04	19	52	2	EFO_0004469, EFO_0008111
Disease	freckles	TYR RAB11FIP2	5.67e-04	20	52	2	EFO_0003963
Disease	Hepatitis, Chronic	ATP7A CP	6.88e-04	22	52	2	C0019189
Disease	Chronic active hepatitis	ATP7A CP	6.88e-04	22	52	2	C0520463
Disease	Cryptogenic Chronic Hepatitis	ATP7A CP	6.88e-04	22	52	2	C0524611
Disease	Chronic Persistent Hepatitis	ATP7A CP	6.88e-04	22	52	2	C0149519
Disease	Malignant neoplasm of prostate	EPHB2 SF3B1 SLC12A2 SMARCAD1 ALOX5 ELAC2	7.28e-04	616	52	6	C0376358
Disease	Visual seizure	ATP7A POLG GABRA5	7.62e-04	101	52	3	C0270824
Disease	Epileptic drop attack	ATP7A POLG GABRA5	7.62e-04	101	52	3	C0270846
Disease	Generalized seizures	ATP7A POLG GABRA5	7.62e-04	101	52	3	C0234533
Disease	Clonic Seizures	ATP7A POLG GABRA5	7.62e-04	101	52	3	C0234535
Disease	Vertiginous seizure	ATP7A POLG GABRA5	7.62e-04	101	52	3	C0422855
Disease	Gustatory seizure	ATP7A POLG GABRA5	7.62e-04	101	52	3	C0422854
Disease	Seizures, Somatosensory	ATP7A POLG GABRA5	7.62e-04	101	52	3	C0422850
Disease	Olfactory seizure	ATP7A POLG GABRA5	7.62e-04	101	52	3	C0422853
Disease	Seizures, Auditory	ATP7A POLG GABRA5	7.62e-04	101	52	3	C0422852
Disease	Generalized Absence Seizures	ATP7A POLG GABRA5	7.62e-04	101	52	3	C4505436
Disease	Convulsive Seizures	ATP7A POLG GABRA5	7.62e-04	101	52	3	C0751494
Disease	Seizures, Sensory	ATP7A POLG GABRA5	7.62e-04	101	52	3	C0751496
Disease	Jacksonian Seizure	ATP7A POLG GABRA5	7.62e-04	101	52	3	C0022333
Disease	Non-epileptic convulsion	ATP7A POLG GABRA5	7.62e-04	101	52	3	C0751056
Disease	Atonic Absence Seizures	ATP7A POLG GABRA5	7.62e-04	101	52	3	C0751123
Disease	Complex partial seizures	ATP7A POLG GABRA5	7.62e-04	101	52	3	C0149958
Disease	Single Seizure	ATP7A POLG GABRA5	7.62e-04	101	52	3	C0751110
Disease	Epileptic Seizures	ATP7A POLG GABRA5	7.62e-04	101	52	3	C4317109
Disease	Nonepileptic Seizures	ATP7A POLG GABRA5	7.62e-04	101	52	3	C3495874
Disease	Tonic Seizures	ATP7A POLG GABRA5	7.84e-04	102	52	3	C0270844
Disease	brain ischemia (biomarker_via_orthology)	CP CTSL CTSV	7.84e-04	102	52	3	DOID:2316 (biomarker_via_orthology)
Disease	Absence Seizures	ATP7A POLG GABRA5	7.84e-04	102	52	3	C4316903
Disease	Convulsions	ATP7A POLG GABRA5	7.84e-04	102	52	3	C4048158
Disease	nephrotic syndrome (biomarker_via_orthology)	CTSL CTSV	8.20e-04	24	52	2	DOID:1184 (biomarker_via_orthology)
Disease	Seizures, Focal	ATP7A POLG GABRA5	8.29e-04	104	52	3	C0751495
Disease	Myoclonic Seizures	ATP7A POLG GABRA5	8.29e-04	104	52	3	C4317123
Disease	Tonic - clonic seizures	ATP7A POLG GABRA5	8.29e-04	104	52	3	C0494475
Disease	Impaired glucose tolerance	SLC12A2 PRKAA2	8.90e-04	25	52	2	C0271650
Disease	Ataxia	ATP7A CP	8.90e-04	25	52	2	C0004134
Disease	erythrocyte measurement	SLC12A2 GMPR BCL11A ALOX5	1.10e-03	257	52	4	EFO_0005047
Disease	Autistic Disorder	SLC9A9 CP PRLR GABRA5	1.16e-03	261	52	4	C0004352
Disease	muscular atrophy (biomarker_via_orthology)	CTSL CTSV	1.20e-03	29	52	2	DOID:767 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FRSMAMLNNMSLVYH	UGT1A3	111	P35503
NSDHMTFMQRVKNML	UGT1A3	201	P35503
SHMMVSFRSCDPNMF	CFAP54	1511	Q96N23
FIHIVGMGMMDFQNS	ADGRB3	681	O60242
HGFTMAMNAFGDMTN	CTSV	71	O60911
HSFTMAMNAFGEMTS	CTSL3P	16	Q5NE16
MNAKIADFGLSNMMS	PRKAA2	151	P54646
LGMVAHMMYSQVFQA	GSG1	201	Q2KHT4
IGQFMFDTMGMTNIL	ECT2L	491	Q008S8
VFFSMADMDMSHSLS	ATG2B	406	Q96BY7
NMSKEEMINLHSSMF	ATP7A	686	Q04656
HLKSFSMANGMNAVM	RAB40C	221	Q96S21
MNAVMMHGRSYSLAS	RAB40C	231	Q96S21
ESNKMHSMNGFMYGN	CP	616	P00450
LQMFFIHMFTGMETV	OR52E4	101	Q8NGH9
FPLMFMEASSMRHFE	PRAMEF17	36	Q5VTA0
LEAMMSAAMGADFHF	GPN2	271	Q9H9Y4
VMQGMVLSSMQHFSE	BCL11A	546	Q9H165
NAGFTSFDVVSQMMM	EPHB2	936	P29323
MGENRTMTIHNGMFF	FGB	391	P02675
QSRMHMNEFNTMSAL	PLXNA4	1836	Q9HCM2
IHSFSFMESSVLLMM	OR51M1	116	Q9H341
FLDTMSMHMAISGLS	POLG	291	P54098
MDNGMFSGFIMIKNL	GABRA5	1	P31644
MNGMNHSVVSEFVFM	OR4F15	1	Q8NGB8
AQMFFVHMLTGMESG	OR52N2	101	Q8NGI0
AQMFFIHAFCMMEST	OR52P1	101	Q8NH57
NFNSLMAIISGMNMS	RASGEF1B	301	Q0VAM2
FTGQEMNVAQFLMHM	NOTUM	456	Q6P988
LMMAVFNMFFLSDSE	ADCY2	691	Q08462
DMTIFDFLMGNMDRH	FAM20C	446	Q8IXL6
HNIMSIFTFMGANVM	HEATR1	1321	Q9H583
QHMLGFAMKSVTQMV	CYP20A1	166	Q6UW02
FEMAAVMSQHSMFTA	GMPR	61	P36959
FQETMEAMHIMGFSH	MYH10	326	P35580
FSSHMPTMQRLFMTQ	PRR14L	1841	Q5THK1
MAQTNSFFMLISSLM	REG1B	1	P48304
LRMGFMTMPASQEHT	NYAP1	56	Q6ZVC0
AMYHSNMTLTMLANF	TAS2R30	171	P59541
QDTLGMTMNHFFSLM	SPEF2	1141	Q9C093
MTMNHFFSLMQAELN	SPEF2	1146	Q9C093
RSKIGSNFQHMMMFA	SLC9A6	441	Q92581
SNFQHMMMFAGLRGA	SLC9A6	446	Q92581
FQHMMMFSGLRGAIA	SLC9A9	431	Q8IVB4
ELMSLLNFVMPHMFS	SMARCAD1	666	Q9H4L7
MENLFINRFMHMFQS	ALOX5	186	P09917
TSAANLRMHIFSMNM	UBA2	356	Q9UBT2
MFTMTRAMEEALFQH	SP110	1	Q9HB58
HSFTMAMNAFGDMTS	CTSL	71	P07711
VGMRMNAEFIMLNHF	ELAC2	711	Q9BQ52
KMSSVQMMFGVNFFS	SLC35B2	296	Q8TB61
MTGFHMQTEDRTMKS	SF3B1	441	O75533
LMNNFQVMSMVSGFT	SLC12A2	586	P55011
MMVNATNQMGSSFSD	PRLR	101	P16471
SMHNALHIYMNGTMS	TYR	361	P14679
LMEQQMSMNNSHSYG	RFX7	796	Q2KHR2
QFMRNNMTASMFDLS	RAB11FIP2	141	Q7L804
MDFSFSFMQGIMGNT	NSD3	1	Q9BZ95
QMSHLFNVAHTLRMM	CAD	1936	P27708
MLSARNSMMFGHLSP	nan	1	A8MV72
SAFCLTPMGMMQFND	ZSWIM8	1796	A7E2V4
MAHLMMFRDVAVDFS	ZNF790	1	Q6PG37
NMFSFAAVMGALDMA	SH2D3C	681	Q8N5H7
LMSMTNATFIGDHMK	WDR7	901	Q9Y4E6