Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription coactivator activity

KAT6B SS18 NCOA1 BCL9L NCOA3 EP300 KAT6A BCL9

2.76e-10303208GO:0003713
GeneOntologyMolecularFunctionhistone acetyltransferase activity

KAT6B NCOA1 NCOA3 EP300 KAT6A

1.34e-0951205GO:0004402
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

KAT6B NCOA1 NCOA3 EP300 KAT6A

1.98e-0955205GO:0061733
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

KAT6B NCOA1 NCOA3 EP300 KAT6A

3.09e-0960205GO:0034212
GeneOntologyMolecularFunctionN-acetyltransferase activity

KAT6B NCOA1 NCOA3 EP300 KAT6A

1.18e-0878205GO:0008080
GeneOntologyMolecularFunctiontranscription coregulator activity

KAT6B SS18 NCOA1 BCL9L NCOA3 EP300 KAT6A BCL9

3.50e-08562208GO:0003712
GeneOntologyMolecularFunctionN-acyltransferase activity

KAT6B NCOA1 NCOA3 EP300 KAT6A

4.60e-08102205GO:0016410
GeneOntologyMolecularFunctionacetyltransferase activity

KAT6B NCOA1 NCOA3 EP300 KAT6A

5.07e-08104205GO:0016407
GeneOntologyMolecularFunctionhistone H3 acetyltransferase activity

KAT6B EP300 KAT6A

3.88e-0715203GO:0010484
GeneOntologyMolecularFunctionhistone modifying activity

KAT6B NCOA1 NCOA3 EP300 KAT6A

2.56e-06229205GO:0140993
GeneOntologyMolecularFunctionacyltransferase activity, transferring groups other than amino-acyl groups

KAT6B NCOA1 NCOA3 EP300 KAT6A

3.09e-06238205GO:0016747
GeneOntologyMolecularFunctionchromatin binding

FOXA2 KAT6B NCOA1 NCOA3 EP300 KAT6A ZIC2

4.70e-06739207GO:0003682
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

KAT6B SS18 NCOA1 BCL9L NCOA3 EP300 KAT6A BCL9

8.51e-061160208GO:0030674
GeneOntologyMolecularFunctionmolecular adaptor activity

KAT6B SS18 NCOA1 BCL9L NCOA3 EP300 KAT6A BCL9

2.67e-051356208GO:0060090
GeneOntologyMolecularFunctionnuclear receptor coactivator activity

SS18 NCOA1 NCOA3

2.98e-0561203GO:0030374
GeneOntologyMolecularFunctionhistone H3K14 acetyltransferase activity

KAT6B KAT6A

3.42e-059202GO:0036408
GeneOntologyMolecularFunctionperoxisome proliferator activated receptor binding

NCOA3 EP300

1.98e-0421202GO:0042975
GeneOntologyMolecularFunctionbeta-catenin binding

BCL9L EP300 BCL9

2.24e-04120203GO:0008013
GeneOntologyMolecularFunctionhistone H4 acetyltransferase activity

EP300 KAT6A

2.38e-0423202GO:0010485
GeneOntologyMolecularFunctionnuclear androgen receptor binding

NCOA3 EP300

4.94e-0433202GO:0050681
GeneOntologyMolecularFunctiontranscription factor binding

FOXA2 NCOA1 NCOA3 EP300 KAT6A

7.28e-04753205GO:0008134
GeneOntologyMolecularFunctionnuclear receptor binding

NCOA1 NCOA3 EP300

8.19e-04187203GO:0016922
GeneOntologyMolecularFunctionacyltransferase activity

KAT6B NCOA1 NCOA3 EP300 KAT6A

8.29e-04775205GO:0016746
GeneOntologyMolecularFunctionnuclear estrogen receptor binding

NCOA1 NCOA3

1.27e-0353202GO:0030331
GeneOntologyMolecularFunctionpre-mRNA binding

EP300 CELF4

1.85e-0364202GO:0036002
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

FOXA2 NCOA3 CREB5 ZIC2

2.07e-03560204GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

FOXA2 NCOA3 CREB5 ZIC2

2.16e-03566204GO:0001216
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

NCOA1 NCOA3 EP300 KAT6A

2.39e-03582204GO:0140297
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

FOXA2 NCOA1 NCOA3 EP300 CREB5 ZIC2

2.39e-031459206GO:0000977
GeneOntologyMolecularFunctionSMAD binding

FOXA2 EP300

3.31e-0386202GO:0046332
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

NCOA1 NCOA3 EP300

7.92e-03417203GO:0061629
GeneOntologyMolecularFunctionchromatin DNA binding

EP300 ZIC2

1.20e-02167202GO:0031490
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

FOXA2 KAT6B SS18 NCOA1 BCL9L NCOA3 EP300 CREB5 ZIC2 BCL9

1.85e-0713902010GO:0045944
GeneOntologyBiologicalProcessstem cell population maintenance

SS18 BCL9L NCOA3 KAT6A BCL9

2.59e-06237205GO:0019827
GeneOntologyBiologicalProcessmaintenance of cell number

SS18 BCL9L NCOA3 KAT6A BCL9

2.86e-06242205GO:0098727
GeneOntologyBiologicalProcesschromatin organization

FOXA2 KAT6B SS18 NCOA1 NCOA3 EP300 KAT6A

1.34e-05896207GO:0006325
GeneOntologyBiologicalProcesscarbon catabolite activation of transcription from RNA polymerase II promoter

FOXA2 NCOA1

2.49e-058202GO:0000436
GeneOntologyBiologicalProcessprotein-DNA complex organization

FOXA2 KAT6B SS18 NCOA1 NCOA3 EP300 KAT6A

2.72e-05999207GO:0071824
GeneOntologyBiologicalProcesscarbon catabolite regulation of transcription from RNA polymerase II promoter

FOXA2 NCOA1

3.20e-059202GO:0000429
GeneOntologyBiologicalProcesscarbon catabolite activation of transcription

FOXA2 NCOA1

3.20e-059202GO:0045991
GeneOntologyBiologicalProcesscarbon catabolite regulation of transcription

FOXA2 NCOA1

4.00e-0510202GO:0045990
GeneOntologyBiologicalProcesschromatin remodeling

KAT6B SS18 NCOA1 NCOA3 EP300 KAT6A

5.30e-05741206GO:0006338
GeneOntologyBiologicalProcesssomatic stem cell population maintenance

BCL9L KAT6A BCL9

1.49e-04108203GO:0035019
GeneOntologyBiologicalProcesschordate embryonic development

FOXA2 NCOA1 NCOA3 EP300 CELF4 ZIC2

1.61e-04906206GO:0043009
GeneOntologyBiologicalProcessembryo development ending in birth or egg hatching

FOXA2 NCOA1 NCOA3 EP300 CELF4 ZIC2

1.85e-04929206GO:0009792
GeneOntologyBiologicalProcesssegmentation

FOXA2 EP300 ZIC2

2.19e-04123203GO:0035282
GeneOntologyBiologicalProcessembryo development

FOXA2 NCOA1 NCOA3 EP300 CELF4 KAT6A ZIC2

2.71e-041437207GO:0009790
GeneOntologyBiologicalProcessconnective tissue development

FOXA2 NCOA1 EP300 CREB5

2.95e-04343204GO:0061448
GeneOntologyBiologicalProcesslabyrinthine layer morphogenesis

NCOA1 NCOA3

3.33e-0428202GO:0060713
GeneOntologyBiologicalProcessembryonic placenta morphogenesis

NCOA1 NCOA3

4.63e-0433202GO:0060669
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

SLC31A1 SS18 BCL9L EP300 ZIC2 BCL9

6.88e-041186206GO:0007167
GeneOntologyBiologicalProcessface morphogenesis

EP300 KAT6A

7.16e-0441202GO:0060325
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

BCL9L EP300 ZIC2 BCL9

7.87e-04445204GO:0141091
GeneOntologyBiologicalProcessregulation of transforming growth factor beta receptor signaling pathway

BCL9L EP300 BCL9

8.05e-04192203GO:0017015
GeneOntologyBiologicalProcessregulation of DNA-binding transcription factor activity

FOXA2 EP300 KAT6A ZIC2

8.14e-04449204GO:0051090
GeneOntologyBiologicalProcessregulation of cellular response to transforming growth factor beta stimulus

BCL9L EP300 BCL9

8.42e-04195203GO:1903844
GeneOntologyBiologicalProcessnuclear receptor-mediated signaling pathway

NCOA1 NCOA3 EP300

9.33e-04202203GO:0141193
GeneOntologyBiologicalProcesshead morphogenesis

EP300 KAT6A

9.81e-0448202GO:0060323
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

BCL9L EP300 ZIC2 BCL9

1.06e-03482204GO:0007178
GeneOntologyBiologicalProcesspositive regulation of stem cell population maintenance

SS18 NCOA3

1.11e-0351202GO:1902459
GeneOntologyBiologicalProcessskeletal muscle tissue development

BCL9L EP300 BCL9

1.24e-03223203GO:0007519
GeneOntologyBiologicalProcesscellular response to nutrient

FOXA2 NCOA1

1.29e-0355202GO:0031670
GeneOntologyBiologicalProcessskeletal muscle organ development

BCL9L EP300 BCL9

1.53e-03240203GO:0060538
GeneOntologyBiologicalProcesshead development

FOXA2 NCOA1 EP300 KAT6A ZIC2

1.54e-03919205GO:0060322
GeneOntologyBiologicalProcesshormone-mediated signaling pathway

NCOA1 NCOA3 EP300

1.61e-03244203GO:0009755
GeneOntologyBiologicalProcesstube development

FOXA2 SLC31A1 NCOA3 EP300 KAT6A ZIC2

1.65e-031402206GO:0035295
GeneOntologyBiologicalProcessface development

EP300 KAT6A

1.68e-0363202GO:0060324
GeneOntologyBiologicalProcessprotein-DNA complex assembly

KAT6B EP300 KAT6A

1.70e-03249203GO:0065004
GeneOntologyBiologicalProcesslabyrinthine layer development

NCOA1 NCOA3

1.74e-0364202GO:0060711
GeneOntologyBiologicalProcessbody morphogenesis

EP300 KAT6A

1.74e-0364202GO:0010171
GeneOntologyBiologicalProcessprotein acetylation

EP300 KAT6A

1.96e-0368202GO:0006473
GeneOntologyBiologicalProcesscellular response to nutrient levels

FOXA2 NCOA1 EP300

1.97e-03262203GO:0031669
GeneOntologyBiologicalProcessnegative regulation of carbohydrate metabolic process

FOXA2 EP300

2.19e-0372202GO:0045912
GeneOntologyBiologicalProcesstransforming growth factor beta receptor signaling pathway

BCL9L EP300 BCL9

2.28e-03276203GO:0007179
GeneOntologyBiologicalProcessin utero embryonic development

FOXA2 NCOA1 NCOA3 CELF4

2.31e-03596204GO:0001701
GeneOntologyBiologicalProcesssomitogenesis

FOXA2 EP300

2.44e-0376202GO:0001756
GeneOntologyBiologicalProcessregulation of stem cell population maintenance

SS18 NCOA3

2.57e-0378202GO:2000036
GeneOntologyBiologicalProcessadipose tissue development

NCOA1 CREB5

2.63e-0379202GO:0060612
GeneOntologyBiologicalProcessmesenchymal cell differentiation

FOXA2 BCL9L ZIC2

2.78e-03296203GO:0048762
GeneOntologyCellularComponenttranscription regulator complex

FOXA2 NCOA1 BCL9L NCOA3 EP300 BCL9

1.44e-05596206GO:0005667
GeneOntologyCellularComponentMOZ/MORF histone acetyltransferase complex

KAT6B KAT6A

1.82e-057202GO:0070776
GeneOntologyCellularComponentH3 histone acetyltransferase complex

KAT6B KAT6A

2.43e-058202GO:0070775
GeneOntologyCellularComponentchromatin

FOXA2 KAT6B SS18 NCOA1 NCOA3 EP300 CREB5 KAT6A

3.61e-051480208GO:0000785
GeneOntologyCellularComponentbeta-catenin-TCF complex

BCL9L BCL9

6.74e-0513202GO:1990907
GeneOntologyCellularComponenthistone acetyltransferase complex

KAT6B EP300 KAT6A

9.50e-0594203GO:0000123
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

NCOA1 BCL9L NCOA3 BCL9

1.15e-04272204GO:0090575
GeneOntologyCellularComponentprotein acetyltransferase complex

KAT6B EP300 KAT6A

1.28e-04104203GO:0031248
GeneOntologyCellularComponentacetyltransferase complex

KAT6B EP300 KAT6A

1.47e-04109203GO:1902493
GeneOntologyCellularComponentnuclear protein-containing complex

SS18 NCOA1 BCL9L NCOA3 PRPF40A BCL9

1.40e-031377206GO:0140513
HumanPhenoLaryngomalacia

KAT6B EP300 KAT6A

8.35e-058463HP:0001601
HumanPhenoAbnormal nasolacrimal system morphology

KAT6B EP300 KAT6A

9.28e-058763HP:0000614
HumanPhenoCleft palate

FOXA2 KAT6B EP300 KAT6A ZIC2

1.70e-0464365HP:0000175
HumanPhenoAbnormal hard palate morphology

FOXA2 KAT6B EP300 KAT6A ZIC2

1.75e-0464765HP:0100737
HumanPhenoAbnormality of the incisor

EP300 KAT6A ZIC2

1.77e-0410863HP:0000676
HumanPhenoCraniofacial cleft

FOXA2 KAT6B EP300 KAT6A ZIC2

2.47e-0469465HP:5201015
HumanPhenoOrofacial cleft

FOXA2 KAT6B EP300 KAT6A ZIC2

2.47e-0469465HP:0000202
HumanPhenoAbnormal lateral ventricle morphology

KAT6B EP300 ZIC2

3.00e-0412963HP:0030047
HumanPhenoAbnormal male external genitalia morphology

FOXA2 KAT6B SLC31A1 EP300 KAT6A ZIC2

3.13e-04132966HP:0000032
HumanPhenoAgenesis of corpus callosum

FOXA2 KAT6B EP300 ZIC2

3.46e-0436564HP:0001274
HumanPhenoAbnormal external genitalia

FOXA2 KAT6B SLC31A1 EP300 KAT6A ZIC2

3.79e-04137266HP:0000811
HumanPhenoDysplastic corpus callosum

FOXA2 KAT6B EP300 ZIC2

4.71e-0439564HP:0006989
HumanPhenoAbnormality of the male genitalia

FOXA2 KAT6B SLC31A1 EP300 KAT6A ZIC2

5.00e-04143766HP:0010461
HumanPhenoAbnormality of tear glands or tear production

KAT6B EP300 KAT6A

5.27e-0415663HP:0000521
HumanPhenoIntestinal malrotation

KAT6B EP300 KAT6A

5.37e-0415763HP:0002566
HumanPhenoNasolacrimal duct obstruction

EP300 KAT6A

7.16e-043662HP:0000579
HumanPhenoAbnormal pattern of respiration

KAT6B SLC31A1 EP300 KAT6A ZIC2

7.50e-0487265HP:0002793
HumanPhenoCerebral visual impairment

SLC31A1 KAT6A ZIC2

7.89e-0417963HP:0100704
HumanPhenoShort hallux

EP300 KAT6A

7.98e-043862HP:0010109
HumanPhenoAbnormality of the helix

KAT6B EP300 KAT6A

8.42e-0418363HP:0000380
HumanPhenoAbnormality of upper lip vermillion

KAT6B EP300 KAT6A ZIC2

8.78e-0446464HP:0011339
HumanPhenoAbnormal external nose morphology

FOXA2 KAT6B EP300 KAT6A ZIC2

9.51e-0491665HP:0010938
HumanPhenoAplasia/hypoplasia involving bones of the lower limbs

KAT6B SLC31A1 EP300 KAT6A

9.54e-0447464HP:0006493
HumanPhenoTemperature instability

SLC31A1 ZIC2

1.02e-034362HP:0005968
HumanPhenoAbnormal antihelix morphology

KAT6B KAT6A

1.02e-034362HP:0009738
HumanPhenoAplasia/Hypoplasia of the hallux

EP300 KAT6A

1.02e-034362HP:0008362
HumanPhenoAbnormal larynx morphology

KAT6B EP300 KAT6A

1.11e-0320163HP:0025423
HumanPhenoAbnormal helix morphology

KAT6B EP300 KAT6A

1.30e-0321263HP:0011039
HumanPhenoAbnormal hallux morphology

KAT6B EP300 KAT6A

1.30e-0321263HP:0001844
HumanPhenoAbnormal upper lip morphology

FOXA2 KAT6B EP300 KAT6A ZIC2

1.32e-0398065HP:0000177
HumanPhenoGastroesophageal reflux

KAT6B EP300 KAT6A ZIC2

1.33e-0351764HP:0002020
HumanPhenoCutaneous syndactyly of toes

EP300 KAT6A

1.38e-035062HP:0010621
HumanPhenoAbnormal lacrimal duct morphology

EP300 KAT6A

1.38e-035062HP:0011481
HumanPhenoHypoplasia of the toes

EP300 KAT6A

1.38e-035062HP:0004701
HumanPhenoCongenital malformation of the great arteries

KAT6B EP300 KAT6A ZIC2

1.45e-0352964HP:0011603
HumanPhenoAplasia/Hypoplasia of the earlobes

EP300 KAT6A

1.55e-035362HP:0009906
HumanPhenoNarrow nasal bridge

EP300 ZIC2

1.55e-035362HP:0000446
HumanPhenoRespiratory distress

SLC31A1 EP300 KAT6A

1.56e-0322663HP:0002098
HumanPhenoBilateral cryptorchidism

EP300 KAT6A

1.61e-035462HP:0008689
HumanPhenoAbnormal posterior pituitary morphogenesis

FOXA2 ZIC2

1.67e-035562HP:0011751
HumanPhenoMedian cleft palate

FOXA2 ZIC2

1.73e-035662HP:0009099
HumanPhenoMedian cleft upper lip

FOXA2 ZIC2

1.73e-035662HP:0000161
HumanPhenoMedian cleft lip and palate

FOXA2 ZIC2

1.73e-035662HP:0008501
HumanPhenoLow hanging columella

EP300 KAT6A

1.73e-035662HP:0009765
HumanPhenoAbnormal incisor morphology

EP300 KAT6A

2.12e-036262HP:0011063
HumanPhenoAbnormal heart valve morphology

KAT6B SLC31A1 EP300 KAT6A

2.18e-0358864HP:0001654
HumanPhenoAbnormal number of incisors

KAT6A ZIC2

2.19e-036362HP:0011064
HumanPhenoHypoplastic ilia

KAT6B EP300

2.19e-036362HP:0000946
HumanPhenoAbnormal nasal dorsum morphology

FOXA2 EP300 ZIC2

2.40e-0326263HP:0011119
HumanPhenoHydronephrosis

KAT6B EP300 KAT6A

2.45e-0326463HP:0000126
MousePhenokinked neural tube

FOXA2 SS18 EP300

5.95e-0557193MP:0003400
MousePhenoabnormal prenatal growth/weight/body size

FOXA2 SLC31A1 SS18 BCL9L NCOA3 EP300 CELF4 KAT6A BCL9

6.01e-051493199MP:0004196
DomainNuc_rcpt_coact

NCOA1 NCOA3 EP300

2.10e-086203IPR009110
DomainBCL9_beta-catenin-bd_dom

BCL9L BCL9

1.09e-062202IPR024670
DomainBCL9

BCL9L BCL9

1.09e-062202PF11502
DomainBcl-9

BCL9L BCL9

1.09e-062202IPR015668
DomainDUF1518

NCOA1 NCOA3

3.27e-063202SM01151
DomainNuc_rcpt_coact_Ncoa-typ

NCOA1 NCOA3

3.27e-063202IPR014920
DomainSRC-1

NCOA1 NCOA3

3.27e-063202IPR014935
DomainSRC-1

NCOA1 NCOA3

3.27e-063202PF08832
DomainDUF1518

NCOA1 NCOA3

3.27e-063202PF07469
Domain-

NCOA1 NCOA3

3.27e-0632024.10.630.10
DomainDUF1518

NCOA1 NCOA3

3.27e-063202IPR010011
DomainNuc_rec_co-act

NCOA1 NCOA3

3.27e-063202PF08815
DomainSrc1_rcpt_coact

NCOA1 NCOA3

3.27e-063202IPR008955
DomainNuclear_rcpt_coactivator

NCOA1 NCOA3

3.27e-063202IPR017426
DomainMOZ_SAS

KAT6B KAT6A

1.09e-055202PF01853
DomainHAT_MYST-type

KAT6B KAT6A

1.09e-055202IPR002717
DomainMYST_HAT

KAT6B KAT6A

1.09e-055202PS51726
DomainH15

KAT6B KAT6A

8.44e-0513202PS51504
DomainH15

KAT6B KAT6A

8.44e-0513202SM00526
DomainHistone_H1/H5_H15

KAT6B KAT6A

9.84e-0514202IPR005818
DomainPAS

NCOA1 NCOA3

3.22e-0425202PF00989
DomainPAS_fold

NCOA1 NCOA3

3.22e-0425202IPR013767
DomainPAS

NCOA1 NCOA3

5.30e-0432202SM00091
DomainPAS

NCOA1 NCOA3

5.99e-0434202IPR000014
DomainPAS

NCOA1 NCOA3

5.99e-0434202PS50112
Domain-

KAT6B KAT6A

8.29e-04402023.40.630.30
DomainAcyl_CoA_acyltransferase

KAT6B KAT6A

1.05e-0345202IPR016181
Domain-

FOXA2 KAT6B KAT6A

1.54e-032182031.10.10.10
DomainWHTH_DNA-bd_dom

FOXA2 KAT6B KAT6A

2.08e-03242203IPR011991
DomainPHD

KAT6B KAT6A

2.88e-0375202PF00628
DomainZnf_PHD-finger

KAT6B KAT6A

3.19e-0379202IPR019787
DomainPHD

KAT6B KAT6A

4.03e-0389202SM00249
DomainZnf_PHD

KAT6B KAT6A

4.21e-0391202IPR001965
DomainZF_PHD_2

KAT6B KAT6A

4.58e-0395202PS50016
DomainZF_PHD_1

KAT6B KAT6A

4.68e-0396202PS01359
Domain-

NCOA1 NCOA3

5.99e-031092024.10.280.10
DomainHLH

NCOA1 NCOA3

6.20e-03111202PF00010
DomainHLH

NCOA1 NCOA3

6.75e-03116202SM00353
DomainBHLH

NCOA1 NCOA3

6.87e-03117202PS50888
DomainbHLH_dom

NCOA1 NCOA3

6.98e-03118202IPR011598
DomainZnf_FYVE_PHD

KAT6B KAT6A

1.07e-02147202IPR011011
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

BCL9L EP300 BCL9

4.46e-0626183MM14793
PathwayPID_RETINOIC_ACID_PATHWAY

NCOA1 NCOA3 EP300

6.95e-0630183M207
PathwayKEGG_MEDICUS_VARIANT_ESR1_POSITIVE_TO_NUCLEAR_INITIATED_ESTROGEN_SIGNALING_PATHWAY

NCOA1 NCOA3

1.54e-055182M48983
PathwayPID_HNF3A_PATHWAY

FOXA2 NCOA3 EP300

2.24e-0544183M285
PathwayREACTOME_HATS_ACETYLATE_HISTONES

KAT6B NCOA1 KAT6A

2.56e-0546183MM14935
PathwayREACTOME_HATS_ACETYLATE_HISTONES

KAT6B NCOA1 EP300 KAT6A

2.71e-05142184M27233
PathwayBIOCARTA_PPARG_PATHWAY

NCOA1 EP300

4.29e-058182M22058
PathwayPID_ERA_GENOMIC_PATHWAY

NCOA1 NCOA3 EP300

6.94e-0564183M200
PathwayKEGG_MEDICUS_REFERENCE_NUCLEAR_INITIATED_ESTROGEN_SIGNALING_PATHWAY

NCOA1 NCOA3

8.41e-0511182M47503
PathwayREACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING

NCOA1 EP300

1.19e-0413182MM15622
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION

NCOA1 NCOA3 EP300

1.56e-0484183M1008
PathwayPID_ERB_GENOMIC_PATHWAY

NCOA1 NCOA3

1.60e-0415182M119
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

BCL9L EP300 BCL9

1.98e-0491183M27101
PathwayWP_ANDROGEN_RECEPTOR_SIGNALING

NCOA1 NCOA3 EP300

1.98e-0491183M39700
PathwayREACTOME_RORA_ACTIVATES_GENE_EXPRESSION

NCOA1 EP300

2.33e-0418182M26942
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KAT6B NCOA1 EP300 KAT6A

3.35e-04272184M29619
PathwayREACTOME_ADIPOGENESIS

NCOA1 NCOA3 EP300

3.46e-04110183M48259
PathwayBIOCARTA_VDR_PATHWAY

NCOA3 EP300

3.50e-0422182MM1370
PathwayBIOCARTA_VDR_PATHWAY

NCOA1 EP300

4.18e-0424182M13404
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

NCOA1 NCOA3 EP300

4.26e-04118183M27316
PathwayREACTOME_GASTRULATION

FOXA2 EP300 ZIC2

5.52e-04129183M46433
PathwayWP_NUCLEAR_RECEPTORS_METAPATHWAY

NCOA1 NCOA3 EP300 ZIC2

5.77e-04314184M39428
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION

EP300 KAT6A

6.13e-0429182MM15340
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION

EP300 KAT6A

6.56e-0430182M27637
PathwayWP_PREGNANE_X_RECEPTOR_PATHWAY

NCOA1 NCOA3

7.47e-0432182M39567
PathwayREACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION

NCOA1 NCOA3 EP300

8.40e-04149183M27888
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

BCL9L EP300 BCL9

9.96e-04158183MM14791
PathwayREACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX

NCOA1 EP300

9.99e-0437182M29790
PathwayREACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS

NCOA1 EP300

1.17e-0340182MM15000
PathwayREACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT

FOXA2 EP300

1.29e-0342182M17541
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

BCL9L BCL9

1.29e-0342182M27272
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KAT6B NCOA1 KAT6A

1.34e-03175183MM14941
PathwayREACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS

NCOA1 EP300

1.41e-0344182M27295
PathwayWP_ARYL_HYDROCARBON_RECEPTOR_PATHWAY_WP2873

NCOA1 EP300

1.48e-0345182M39615
PathwayREACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING

NCOA1 EP300

1.61e-0347182M29777
PathwayWP_ENERGY_METABOLISM

NCOA1 EP300

1.68e-0348182M39590
PathwayPID_HES_HEY_PATHWAY

NCOA1 EP300

1.68e-0348182M288
PathwayREACTOME_HEME_SIGNALING

NCOA1 EP300

1.75e-0349182M41832
PathwayBIOCARTA_PPARA_PATHWAY

NCOA1 EP300

1.97e-0352182M2404
PathwayPID_AR_TF_PATHWAY

NCOA1 EP300

2.04e-0353182M151
PathwayREACTOME_ESR_MEDIATED_SIGNALING

NCOA1 NCOA3 EP300

2.57e-03220183M27794
PathwayREACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION

NCOA1 EP300

2.87e-0363182MM15613
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

BCL9L EP300 BCL9

3.03e-03233183M27099
PathwayWP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA

EP300 KAT6A

3.05e-0365182M39682
PathwayPID_HIF1_TFPATHWAY

NCOA1 EP300

3.15e-0366182M255
PathwayREACTOME_SIGNALING_BY_WNT

BCL9L EP300 BCL9

3.25e-03239183MM14756
PathwayREACTOME_CIRCADIAN_CLOCK

NCOA1 EP300

3.53e-0370182M938
PathwayPID_BETA_CATENIN_NUC_PATHWAY

EP300 BCL9

4.59e-0380182M223
PathwayPID_REG_GR_PATHWAY

NCOA1 EP300

4.81e-0382182M115
PathwayPID_SMAD2_3NUCLEAR_PATHWAY

NCOA1 EP300

4.81e-0382182M2
PathwayKEGG_PROSTATE_CANCER

EP300 CREB5

5.65e-0389182M13191
PathwayWNT_SIGNALING

EP300 BCL9

5.65e-0389182M5493
PathwayREACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS

NCOA1 NCOA3 EP300

5.92e-03296183M27869
PathwayWP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY

NCOA1 EP300 ZIC2

6.20e-03301183MM15983
Pubmed

New nomenclature for chromatin-modifying enzymes.

KAT6B NCOA1 NCOA3 EP300 KAT6A

1.50e-105720518022353
Pubmed

Posttranslational acetylation of the human immunodeficiency virus type 1 integrase carboxyl-terminal domain is dispensable for viral replication.

KAT6B EP300 KAT6A

1.62e-09520317182677
Pubmed

SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4.

NCOA1 NCOA3 EP300

1.62e-0952039812974
Pubmed

Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains.

NCOA1 NCOA3 EP300

1.62e-09520312714702
Pubmed

Temporal/spatial expression of nuclear receptor coactivators in the mouse lung.

NCOA1 NCOA3 EP300

3.25e-09620311076796
Pubmed

Roles of coactivators in hypoxic induction of the erythropoietin gene.

NCOA1 NCOA3 EP300

3.25e-09620320368990
Pubmed

Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly.

NCOA1 NCOA3 EP300

3.25e-09620316923966
Pubmed

The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine.

NCOA1 NCOA3 EP300

5.68e-09720312709428
Pubmed

The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment.

NCOA1 NCOA3 EP300

9.09e-09820312082103
Pubmed

Aberrant association of promyelocytic leukemia protein-retinoic acid receptor-alpha with coactivators contributes to its ability to regulate gene expression.

NCOA1 NCOA3 EP300

9.09e-09820317475621
Pubmed

Acetylation of HIV-1 integrase by p300 regulates viral integration.

KAT6B EP300 KAT6A

2.68e-081120316096645
Pubmed

Multiplexed molecular interactions of nuclear receptors using fluorescent microspheres.

NCOA1 NCOA3 EP300

5.90e-081420311500849
Pubmed

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.

FOXA2 KAT6B SLC31A1 NCOA1 NCOA3 KAT6A

1.06e-0742420621731673
Pubmed

Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.

BCL9L NCOA3 PRPF40A EP300 CREB5 BCL9

1.08e-0742520624999758
Pubmed

Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.

NCOA1 NCOA3 EP300

1.10e-071720319183483
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

FOXA2 BCL9L NCOA3 PRPF40A EP300 BCL9

1.65e-0745720632344865
Pubmed

T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.

NCOA1 NCOA3 EP300

1.84e-072020311877444
Pubmed

Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.

NCOA1 NCOA3 EP300

2.15e-072120319596656
Pubmed

Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells.

FOXA2 NCOA1 NCOA3

2.86e-072320319737349
Pubmed

p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion.

SS18 EP300

3.14e-07220211030627
Pubmed

Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance.

NCOA1 NCOA3

3.14e-07220216459312
Pubmed

MOZ is fused to p300 in an acute monocytic leukemia with t(8;22).

EP300 KAT6A

3.14e-07220210824998
Pubmed

The coactivator SRC-1 is an essential coordinator of hepatic glucose production.

NCOA1 NCOA3

3.14e-07220221109193
Pubmed

ERα status of invasive ductal breast carcinoma as a result of regulatory interactions between lysine deacetylases KAT6A and KAT6B.

KAT6B KAT6A

3.14e-07220239505971
Pubmed

Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor.

NCOA1 NCOA3

3.14e-07220216141356
Pubmed

Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas.

BCL9L BCL9

3.14e-07220220682801
Pubmed

Immunohistochemical localization of steroid receptor coactivators in chondrosarcoma: an in vivo tissue microarray study.

NCOA1 NCOA3

3.14e-07220224875297
Pubmed

Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration.

BCL9L BCL9

3.14e-07220238811552
Pubmed

NCOA3, a new fusion partner for MOZ/MYST3 in M5 acute myeloid leukemia.

NCOA3 KAT6A

3.14e-07220217805331
Pubmed

BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.

BCL9L BCL9

3.14e-07220233767438
Pubmed

Regulation of KAT6 Acetyltransferases and Their Roles in Cell Cycle Progression, Stem Cell Maintenance, and Human Disease.

KAT6B KAT6A

3.14e-07220227185879
Pubmed

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.

BCL9L BCL9

3.14e-07220215371335
Pubmed

The double PHD finger domain of MOZ/MYST3 induces α-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification.

KAT6B KAT6A

3.14e-07220224150941
Pubmed

Role of accessory factors and steroid receptor coactivator 1 in the regulation of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids.

FOXA2 NCOA1

3.14e-07220211069927
Pubmed

Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.

NCOA1 NCOA3 EP300

5.28e-072820324880616
Pubmed

MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain.

KAT6B KAT6A

9.42e-07320236754959
Pubmed

Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.

NCOA1 EP300

9.42e-07320211773079
Pubmed

The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles.

NCOA1 NCOA3

9.42e-07320221035760
Pubmed

Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators.

NCOA3 EP300

9.42e-07320211823864
Pubmed

Expression and significance of androgen receptor coactivators in urothelial carcinoma of the bladder.

NCOA1 NCOA3

9.42e-07320218845648
Pubmed

The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP.

NCOA1 NCOA3

9.42e-07320212138202
Pubmed

Distinctive functions of p160 steroid receptor coactivators in proliferation of an estrogen-independent, tamoxifen-resistant breast cancer cell line.

NCOA1 NCOA3

9.42e-07320221059860
Pubmed

AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor.

NCOA3 EP300

9.42e-07320210866661
Pubmed

The transcriptional co-activator p/CIP (NCoA-3) is up-regulated by STAT6 and serves as a positive regulator of transcriptional activation by STAT6.

NCOA3 EP300

9.42e-07320215145939
Pubmed

The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.

NCOA1 EP300

9.42e-0732028855229
Pubmed

Dynamics changes in the transcription factors during early human embryonic development.

FOXA2 EP300

9.42e-07320230246428
Pubmed

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1.

NCOA1 NCOA3

9.42e-0732029832502
Pubmed

Tandem PHD fingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin.

KAT6B KAT6A

9.42e-07320223063713
Pubmed

The interactions of Bcl9/Bcl9L with β-catenin and Pygopus promote breast cancer growth, invasion, and metastasis.

BCL9L BCL9

9.42e-07320234545187
Pubmed

Absence of the steroid receptor coactivator-3 induces B-cell lymphoma.

NCOA1 NCOA3

9.42e-07320216675958
Pubmed

Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells.

BCL9L BCL9

9.42e-07320233649334
Pubmed

Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene.

NCOA1 NCOA3

9.42e-0732029506940
Pubmed

Structure and chromosomal locations of mouse steroid receptor coactivator gene family.

NCOA1 NCOA3

9.42e-07320210501088
Pubmed

Estradiol increases cell growth in human astrocytoma cell lines through ERα activation and its interaction with SRC-1 and SRC-3 coactivators.

NCOA1 NCOA3

9.42e-07320222142990
Pubmed

Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers.

NCOA1 NCOA3

9.42e-07320228390937
Pubmed

The transcriptional coactivators p/CIP and SRC-1 control insulin resistance through IRS1 in obesity models.

NCOA1 NCOA3

9.42e-07320222859932
Pubmed

The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis.

NCOA1 NCOA3

9.42e-07320219383905
Pubmed

p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha.

NCOA1 EP300

9.42e-0732029407140
Pubmed

Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor.

BCL9L BCL9

9.42e-07320220637214
Pubmed

A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment.

NCOA1 NCOA3

9.42e-07320232963012
Pubmed

Mediator and p300/CBP-steroid receptor coactivator complexes have distinct roles, but function synergistically, during estrogen receptor alpha-dependent transcription with chromatin templates.

NCOA1 EP300

9.42e-07320212482985
Pubmed

Research resource: loss of the steroid receptor coactivators confers neurobehavioral consequences.

NCOA1 NCOA3

9.42e-07320223927929
Pubmed

Co-activator SRC-1 is dispensable for transcriptional control by STAT3.

NCOA1 EP300

9.42e-07320219203349
Pubmed

The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription.

NCOA3 EP300

9.42e-07320212569362
Pubmed

The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolism.

NCOA1 NCOA3

9.42e-07320216423883
Pubmed

Interaction network of human early embryonic transcription factors.

NCOA1 BCL9L NCOA3 EP300 BCL9

1.39e-0635120538297188
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

NCOA1 NCOA3 EP300 BCL9

1.61e-0615220438360978
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

KAT6B SS18 EP300 KAT6A

1.83e-0615720430186101
Pubmed

miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation.

NCOA1 NCOA3

1.88e-06420226066330
Pubmed

CBP/p300 interact with and function as transcriptional coactivators of BRCA1.

NCOA3 EP300

1.88e-06420210655477
Pubmed

Steroid receptor coactivator-1 and its family members differentially regulate transactivation by the tumor suppressor protein p53.

NCOA1 NCOA3

1.88e-06420210551785
Pubmed

Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1).

NCOA3 EP300

1.88e-06420216227615
Pubmed

Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator.

SS18 NCOA1

1.88e-06420215919756
Pubmed

Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1.

NCOA1 EP300

1.88e-06420211113179
Pubmed

Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma.

NCOA3 EP300

1.88e-06420233589584
Pubmed

Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes.

NCOA3 EP300

1.88e-06420232668201
Pubmed

Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF).

KAT6B KAT6A

1.88e-06420221880731
Pubmed

Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.

NCOA1 NCOA3

1.88e-06420222560224
Pubmed

The interaction of ETV6 (TEL) and TIP60 requires a functional histone acetyltransferase domain in TIP60.

KAT6B KAT6A

1.88e-06420217980166
Pubmed

P160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain.

NCOA1 NCOA3

1.88e-06420218267973
Pubmed

Selective recruitment of p160 coactivators on glucocorticoid-regulated promoters in Schwann cells.

NCOA1 NCOA3

1.88e-06420215331759
Pubmed

Cyclic changes in the expression of steroid receptor coactivators and corepressors in the normal human endometrium.

NCOA1 EP300

1.88e-06420212574227
Pubmed

A simple method to screen ligands of peroxisome proliferator-activated receptor delta.

NCOA1 EP300

1.88e-06420216930961
Pubmed

Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators.

NCOA1 EP300

1.88e-06420212208951
Pubmed

Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death.

NCOA1 NCOA3

1.88e-06420226267537
Pubmed

A transcriptional switch mediated by cofactor methylation.

NCOA3 EP300

1.88e-06420211701890
Pubmed

BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration.

BCL9L BCL9

1.88e-06420219699733
Pubmed

The oncoprotein Tax binds the SRC-1-interacting domain of CBP/p300 to mediate transcriptional activation.

NCOA1 EP300

1.88e-06420211463834
Pubmed

Mutation of a lysine residue in a homeodomain generates dominant negative thyroid transcription factor 1.

NCOA1 NCOA3

1.88e-06420215449938
Pubmed

Nuclear receptor coregulator SNP discovery and impact on breast cancer risk.

NCOA1 NCOA3

1.88e-06420220003447
Pubmed

The steroid receptor co-activator-1 (SRC-1) potentiates TGF-beta/Smad signaling: role of p300/CBP.

NCOA1 EP300

1.88e-06420215688032
Pubmed

Unique roles of p160 coactivators for regulation of breast cancer cell proliferation and estrogen receptor-alpha transcriptional activity.

NCOA1 NCOA3

1.88e-06420219095746
Pubmed

Nuclear hormone receptor coregulator GRIP1 suppresses, whereas SRC1A and p/CIP coactivate, by domain-specific binding of MyoD.

NCOA1 NCOA3

1.88e-06420215563453
Pubmed

Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene.

NCOA1 NCOA3

3.14e-06520210652338
Pubmed

Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models.

BCL9L BCL9

3.14e-06520230760710
Pubmed

Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor.

NCOA1 NCOA3

3.14e-06520218798693
Pubmed

Isoform-selective interactions between estrogen receptors and steroid receptor coactivators promoted by estradiol and ErbB-2 signaling in living cells.

NCOA1 NCOA3

3.14e-06520212554772
Pubmed

Redundant enhancement of mouse constitutive androstane receptor transactivation by p160 coactivator family members.

NCOA1 NCOA3

3.14e-06520217950690
Pubmed

Structure of a biologically active estrogen receptor-coactivator complex on DNA.

NCOA3 EP300

3.14e-06520225728767
Pubmed

SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm.

NCOA1 NCOA3

3.14e-06520217476305
InteractionSP7 interactions

SS18 NCOA1 BCL9L NCOA3 PRPF40A EP300 BCL9

1.09e-08304207int:SP7
InteractionGSC interactions

FOXA2 BCL9L NCOA3 EP300 BCL9

1.97e-0887205int:GSC
InteractionFOS interactions

SS18 NCOA1 NCOA3 EP300 CREB5 BCL9

4.24e-07312206int:FOS
InteractionGCM1 interactions

SS18 NCOA3 EP300 BCL9

5.51e-0768204int:GCM1
InteractionEGR2 interactions

NCOA1 BCL9L NCOA3 EP300 BCL9

5.80e-07171205int:EGR2
InteractionETV4 interactions

SS18 NCOA3 EP300 BCL9

5.85e-0769204int:ETV4
InteractionMYOD1 interactions

SS18 NCOA1 NCOA3 EP300 BCL9

1.08e-06194205int:MYOD1
InteractionEWSR1 interactions

BCL9L NCOA3 PRPF40A EP300 CREB5 CLINT1 KAT6A BCL9

1.26e-06906208int:EWSR1
InteractionERG interactions

SS18 NCOA3 PRPF40A EP300 BCL9

2.15e-06223205int:ERG
InteractionNUP35 interactions

FOXA2 BCL9L NCOA3 PRPF40A EP300 BCL9

2.53e-06424206int:NUP35
InteractionCRX interactions

NCOA1 BCL9L NCOA3 EP300 BCL9

4.06e-06254205int:CRX
InteractionTBR1 interactions

BCL9L NCOA3 EP300 BCL9

4.24e-06113204int:TBR1
InteractionTBXT interactions

SS18 NCOA3 EP300 BCL9

4.70e-06116204int:TBXT
InteractionHNF4A interactions

FOXA2 SS18 NCOA1 NCOA3 EP300

5.98e-06275205int:HNF4A
InteractionPAX7 interactions

SS18 NCOA3 EP300 BCL9

6.13e-06124204int:PAX7
InteractionSMARCE1 interactions

SS18 NCOA1 NCOA3 PRPF40A EP300

7.36e-06287205int:SMARCE1
InteractionPAX9 interactions

BCL9L NCOA3 EP300 BCL9

7.39e-06130204int:PAX9
InteractionHEMGN interactions

DCAF15 EP300 KAT6A

1.08e-0544203int:HEMGN
InteractionNCOA1 interactions

FOXA2 NCOA1 NCOA3 EP300

1.17e-05146204int:NCOA1
InteractionRARB interactions

NCOA1 NCOA3 EP300

1.23e-0546203int:RARB
InteractionNR1I2 interactions

NCOA1 NCOA3 EP300

1.41e-0548203int:NR1I2
InteractionTLX1 interactions

NCOA3 EP300 KAT6A BCL9

2.39e-05175204int:TLX1
InteractionRARG interactions

NCOA1 NCOA3 EP300

2.49e-0558203int:RARG
InteractionNR1H3 interactions

NCOA1 NCOA3 EP300

2.49e-0558203int:NR1H3
InteractionSSBP4 interactions

BCL9L EP300 BCL9

2.62e-0559203int:SSBP4
InteractionTLE3 interactions

NCOA1 BCL9L NCOA3 EP300 BCL9

2.71e-05376205int:TLE3
InteractionALG13 interactions

NCOA3 PRPF40A EP300 BCL9

2.84e-05183204int:ALG13
InteractionETS2 interactions

NCOA1 NCOA3 EP300

2.90e-0561203int:ETS2
InteractionSMARCC1 interactions

SS18 NCOA1 NCOA3 PRPF40A EP300

3.00e-05384205int:SMARCC1
InteractionAR interactions

NCOA1 BCL9L NCOA3 PRPF40A MLF2 EP300 BCL9

3.02e-05992207int:AR
InteractionGATA3 interactions

NCOA3 PRPF40A EP300 BCL9

3.10e-05187204int:GATA3
InteractionSOX2 interactions

KAT6B SS18 BCL9L NCOA3 MLF2 EP300 CLINT1 BCL9

3.52e-051422208int:SOX2
InteractionKLF5 interactions

SS18 NCOA3 EP300 BCL9

3.65e-05195204int:KLF5
InteractionGATA2 interactions

SS18 NCOA3 EP300 BCL9

3.95e-05199204int:GATA2
InteractionASCC1 interactions

NCOA1 EP300 KAT6A

4.58e-0571203int:ASCC1
InteractionING4 interactions

KAT6B EP300 KAT6A

6.06e-0578203int:ING4
InteractionHNF1A interactions

NCOA1 NCOA3 EP300

6.54e-0580203int:HNF1A
InteractionCDK12 interactions

DCAF15 PRPF40A EP300 KAT6A

6.70e-05228204int:CDK12
InteractionSOX7 interactions

NCOA1 NCOA3 EP300

7.04e-0582203int:SOX7
InteractionSMARCA4 interactions

SS18 NCOA1 PRPF40A EP300 KAT6A

7.23e-05462205int:SMARCA4
InteractionPGR interactions

NCOA1 NCOA3 EP300

7.57e-0584203int:PGR
InteractionJUN interactions

NCOA1 NCOA3 EP300 CREB5 CLINT1

7.84e-05470205int:JUN
InteractionIRF4 interactions

SS18 NCOA3 EP300

7.84e-0585203int:IRF4
InteractionSTAT6 interactions

NCOA1 NCOA3 EP300

8.40e-0587203int:STAT6
InteractionEYA4 interactions

NCOA1 NCOA3 EP300 BCL9

8.58e-05243204int:EYA4
InteractionPPARA interactions

NCOA1 NCOA3 EP300

9.92e-0592203int:PPARA
InteractionFOXI1 interactions

NCOA3 EP300 BCL9

9.92e-0592203int:FOXI1
InteractionSOX10 interactions

NCOA3 EP300 BCL9

9.92e-0592203int:SOX10
InteractionHOXA5 interactions

FOXA2 PRPF40A KAT6A

1.06e-0494203int:HOXA5
InteractionSOX17 interactions

SS18 NCOA3 BCL9

1.09e-0495203int:SOX17
InteractionSOX9 interactions

NCOA3 EP300 BCL9

1.16e-0497203int:SOX9
InteractionAMBRA1 interactions

RAB40C PRPF40A MLF2 KAT6A

1.20e-04265204int:AMBRA1
InteractionPOP1 interactions

PRPF40A MLF2 EP300 KAT6A

1.42e-04277204int:POP1
InteractionSSBP2 interactions

BCL9L EP300 BCL9

1.47e-04105203int:SSBP2
InteractionWDR44 interactions

SLC31A1 DCAF15 EP300

1.47e-04105203int:WDR44
InteractionCCND1 interactions

NCOA1 NCOA3 MLF2 EP300

1.61e-04286204int:CCND1
InteractionKLF15 interactions

NCOA1 NCOA3 EP300 BCL9

1.70e-04290204int:KLF15
InteractionTLX3 interactions

BCL9L NCOA3 EP300 BCL9

1.72e-04291204int:TLX3
InteractionPAX8 interactions

NCOA3 EP300 BCL9

1.73e-04111203int:PAX8
InteractionTHRA interactions

NCOA1 NCOA3 EP300

1.73e-04111203int:THRA
InteractionFOXM1 interactions

SLC31A1 DCAF15 EP300

1.83e-04113203int:FOXM1
InteractionING5 interactions

KAT6B EP300 KAT6A

1.87e-04114203int:ING5
InteractionLDB1 interactions

BCL9L EP300 BCL9

1.92e-04115203int:LDB1
InteractionKLF13 interactions

EP300 KAT6A

1.94e-0421202int:KLF13
InteractionPPARD interactions

NCOA1 NCOA3 EP300

2.02e-04117203int:PPARD
InteractionHNF4G interactions

NCOA1 NCOA3

2.14e-0422202int:HNF4G
InteractionETS1 interactions

NCOA1 NCOA3 EP300

2.23e-04121203int:ETS1
InteractionRUNX2 interactions

KAT6B NCOA1 EP300

2.52e-04126203int:RUNX2
InteractionNR6A1 interactions

NCOA1 EP300

2.55e-0424202int:NR6A1
InteractionVDR interactions

NCOA1 NCOA3 EP300

2.58e-04127203int:VDR
InteractionEP300 interactions

SS18 NCOA1 NCOA3 PRPF40A EP300 CLINT1 KAT6A

2.68e-041401207int:EP300
InteractionRABL6 interactions

DCAF15 PRPF40A EP300

2.76e-04130203int:RABL6
InteractionTLE6 interactions

NCOA3 EP300

2.77e-0425202int:TLE6
InteractionSETSIP interactions

EP300 KAT6A

2.77e-0425202int:SETSIP
InteractionPYGO1 interactions

BCL9L BCL9

3.48e-0428202int:PYGO1
InteractionSOX15 interactions

NCOA3 EP300 BCL9

3.50e-04141203int:SOX15
InteractionNCOA2 interactions

NCOA1 NCOA3 EP300

3.50e-04141203int:NCOA2
InteractionGTF2B interactions

NCOA1 NCOA3 EP300

3.50e-04141203int:GTF2B
InteractionSMARCC2 interactions

SS18 NCOA3 PRPF40A EP300

3.59e-04353204int:SMARCC2
InteractionETV1 interactions

NCOA3 EP300

3.74e-0429202int:ETV1
InteractionMN1 interactions

NCOA3 EP300

3.74e-0429202int:MN1
InteractionMYOCD interactions

NCOA3 EP300

3.74e-0429202int:MYOCD
InteractionTOE1 interactions

RAB40C EP300 KAT6A

3.88e-04146203int:TOE1
InteractionELF5 interactions

SS18 PRPF40A EP300

3.96e-04147203int:ELF5
InteractionDDA1 interactions

RAB40C DCAF15 EP300 KAT6A

4.20e-04368204int:DDA1
InteractionTCEAL9 interactions

DCAF15 PRPF40A

4.28e-0431202int:TCEAL9
InteractionSPATA1 interactions

PRPF40A EP300

4.28e-0431202int:SPATA1
InteractionH4C16 interactions

NCOA3 EP300 KAT6A

4.36e-04152203int:H4C16
InteractionNR1H4 interactions

NCOA1 EP300

4.56e-0432202int:NR1H4
InteractionZRANB3 interactions

SLC31A1 DCAF15

4.85e-0433202int:ZRANB3
InteractionMEX3A interactions

SS18 BCL9L EP300 KAT6A

4.94e-04384204int:MEX3A
InteractionYLPM1 interactions

DCAF15 PRPF40A EP300

5.07e-04160203int:YLPM1
InteractionKLF4 interactions

NCOA3 EP300 BCL9

5.07e-04160203int:KLF4
InteractionKAT6B interactions

KAT6B KAT6A

5.15e-0434202int:KAT6B
InteractionFOXA2 interactions

FOXA2 NCOA1

5.46e-0435202int:FOXA2
InteractionPPIL4 interactions

PRPF40A EP300 KAT6A

5.55e-04165203int:PPIL4
InteractionHOXB2 interactions

NCOA1 EP300

5.78e-0436202int:HOXB2
InteractionRXRA interactions

NCOA1 NCOA3 EP300

5.95e-04169203int:RXRA
InteractionNRIP1 interactions

NCOA1 NCOA3 PRPF40A

6.05e-04170203int:NRIP1
InteractionGATA1 interactions

PRPF40A EP300 BCL9

6.15e-04171203int:GATA1
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

KAT6B NCOA1 NCOA3 EP300 KAT6A

3.03e-1317125486
GeneFamilyZinc fingers C2HC-type|PHD finger proteins|Lysine acetyltransferases

KAT6B KAT6A

4.82e-051612266
GeneFamilyPHD finger proteins

KAT6B KAT6A

1.57e-039012288
GeneFamilyBasic helix-loop-helix proteins

NCOA1 NCOA3

2.33e-03110122420
CoexpressionGSE7764_IL15_NK_CELL_24H_VS_SPLENOCYTE_DN

NCOA3 EP300 KAT6A BCL9

1.42e-05199204M5726
CoexpressionGSE45881_CXCR6HI_VS_CXCR1LO_COLONIC_LAMINA_PROPRIA_UP

DCAF15 PRPF40A EP300 KAT6A

1.45e-05200204M9889
CoexpressionGSE17721_PAM3CSK4_VS_GADIQUIMOD_2H_BMDC_DN

RAB40C NCOA1 DCAF15 CLINT1

1.45e-05200204M3965
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

KAT6B NCOA1 NCOA3 CREB5 CLINT1 KAT6A

3.12e-05856206M4500
CoexpressionGRESHOCK_CANCER_COPY_NUMBER_UP

KAT6B SS18 EP300 BCL9

9.38e-05323204M9150
CoexpressionZHONG_PFC_C5_BCL11B_CALB2_POS_INP

KAT6B CELF4

1.27e-0422202M39085
CoexpressionGSE3920_UNTREATED_VS_IFNG_TREATED_FIBROBLAST_UP

FOXA2 NCOA1 DCAF15

2.63e-04166203M6688
CoexpressionGSE6269_FLU_VS_STREP_PNEUMO_INF_PBMC_UP

NCOA3 DCAF15 PRPF40A

2.82e-04170203M5657
CoexpressionGENTILE_UV_RESPONSE_CLUSTER_D5

SS18 NCOA3

3.24e-0435202M13814
CoexpressionGSE37301_CD4_TCELL_VS_RAG2_KO_NK_CELL_DN

NCOA1 EMC3 KAT6A

3.33e-04180203M8906
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

KAT6B NCOA1 NCOA3 KAT6A

3.81e-04466204M13522
CoexpressionGSE19772_CTRL_VS_HCMV_INF_MONOCYTES_AND_PI3K_INHIBITION_UP

PRPF40A MLF2 CREB5

4.15e-04194203M7288
CoexpressionGSE3982_DC_VS_NEUTROPHIL_LPS_STIM_DN

DCAF15 MLF2 CREB5

4.15e-04194203M5393
CoexpressionGSE45382_UNTREATED_VS_TGFB_TREATED_MACROPHAGES_DN

BCL9L PRPF40A CREB5

4.21e-04195203M9804
CoexpressionDESCARTES_ORGANOGENESIS_PREMATURE_OLIGODENDROCYTE

KAT6B CREB5

4.24e-0440202MM3636
CoexpressionGSE26290_CTRL_VS_AKT_INHIBITOR_TREATED_ANTI_CD3_AND_IL2_STIM_CD8_TCELL_DN

NIPAL3 NCOA3 BCL9

4.34e-04197203M8133
CoexpressionGSE360_L_DONOVANI_VS_T_GONDII_DC_DN

KAT6B PRPF40A MLF2

4.34e-04197203M5196
CoexpressionGSE18281_SUBCAPSULAR_CORTICAL_REGION_VS_WHOLE_MEDULLA_THYMUS_UP

NCOA1 EP300 BCL9

4.47e-04199203M7254
CoexpressionGSE17721_CTRL_VS_GARDIQUIMOD_0.5H_BMDC_DN

NCOA3 PRPF40A EMC3

4.47e-04199203M3775
CoexpressionGSE22886_NAIVE_CD4_TCELL_VS_12H_ACT_TH2_UP

NIPAL3 KAT6B KAT6A

4.47e-04199203M4526
CoexpressionGSE17322_CD103_POS_VS_CD11B_HIGH_LUNG_DC_DN

KAT6B SLC31A1 BCL9L

4.47e-04199203M7390
CoexpressionGSE36527_CD69_NEG_VS_POS_TREG_CD62L_LOS_KLRG1_NEG_DN

RAB40C DCAF15 EMC3

4.53e-04200203M9029
CoexpressionGSE41867_DAY6_EFFECTOR_VS_DAY30_MEMORY_CD8_TCELL_LCMV_ARMSTRONG_UP

NIPAL3 EP300 EMC3

4.53e-04200203M9458
CoexpressionGSE24726_WT_VS_E2_2_KO_PDC_UP

NIPAL3 RAB40C NCOA3

4.53e-04200203M8060
CoexpressionGSE31622_WT_VS_KLF3_KO_BCELL_UP

FOXA2 DCAF15 CELF4

4.53e-04200203M8473
CoexpressionGSE21360_NAIVE_VS_QUATERNARY_MEMORY_CD8_TCELL_UP

NIPAL3 SLC31A1 NCOA3

4.53e-04200203M7613
CoexpressionGSE21360_NAIVE_VS_QUATERNARY_MEMORY_CD8_TCELL_DN

NIPAL3 SLC31A1 NCOA3

4.53e-04200203M7618
CoexpressionGSE17721_POLYIC_VS_CPG_12H_BMDC_UP

NCOA1 NCOA3 MLF2

4.53e-04200203M3948
CoexpressionGSE16450_IMMATURE_VS_MATURE_NEURON_CELL_LINE_6H_IFNA_STIM_DN

SLC31A1 DCAF15 CREB5

4.53e-04200203M7415
CoexpressionMURARO_PANCREAS_BETA_CELL

FOXA2 KAT6B NCOA3 CELF4 BCL9

5.98e-04946205M39169
CoexpressionBENITEZ_GBM_PROTEASOME_INHIBITION_RESPONSE

MLF2 EP300

6.11e-0448202M40000
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

KAT6B NCOA1 NCOA3 PRPF40A EP300 KAT6A

6.53e-041492206M40023
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Neuronal-Intermediate|2m / Sample Type, Dataset, Time_group, and Cell type.

FOXA2 KAT6B CREB5 CELF4

1.74e-062002042a635694844ddabcd98462c5636a6f41a3f08a46
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NIPAL3 SLC31A1 DCAF15

4.38e-0515520393f21b09f6f7755991d67886361b1c42a50fbbfc
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9|TCGA-Bladder / Sample_Type by Project: Shred V9

BCL9L NCOA3 CLINT1

5.86e-05171203adbcfa4bf6bc1c604535a24435924cdb091e2dd7
ToppCelldroplet-Marrow-nan-3m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EP300 CLINT1 KAT6A

7.06e-05182203f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EP300 CLINT1 KAT6A

7.29e-051842031154a5ad7b8512272b7476f949ddac350910bfb7
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EP300 CLINT1 KAT6A

7.41e-051852037adfa929930cfa795cbfbd9f1a0b439e08aa765d
Druganacardic acid

KAT6B NCOA1 EP300 KAT6A

1.17e-0830204CID000167551
DrugAC1L1COZ

KAT6B NCOA1 NCOA3 EP300 KAT6A

1.28e-0890205CID000001996
DrugTiNi

KAT6B SLC31A1 NCOA3 EP300 KAT6A

2.17e-08100205CID000159408
DrugAC1L1G5B

KAT6B NCOA1 EP300 KAT6A

6.90e-0846204CID000003531
Drugglutamin

KAT6B NCOA1 NCOA3 PRPF40A MLF2 EP300 KAT6A

8.23e-08461207CID000000738
Drugvorinostat

KAT6B NCOA1 NCOA3 PRPF40A EP300 KAT6A

2.16e-07314206CID000005311
DrugIn-G

KAT6B NCOA1 NCOA3 EP300 KAT6A

3.10e-07170205CID000446054
DrugCV-1

SS18 NCOA1 NCOA3 EP300 CREB5

9.45e-07213205CID000130105
Drugmelatonin

KAT6B NCOA1 NCOA3 PRPF40A EP300 KAT6A

1.61e-06443206CID000000896
DrugAC1L2E0P

KAT6B NCOA1 NCOA3 EP300 KAT6A

5.67e-06307205CID000019390
Drugbutamben

NCOA1 NCOA3

1.10e-056202ctd:C004605
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

KAT6B SS18 DCAF15 EP300

1.42e-051732044237_DN
DrugPhenoxybenzamine hydrochloride [63-92-3]; Down 200; 11.8uM; PC3; HT_HG-U133A

FOXA2 SS18 NCOA1 DCAF15

1.55e-051772044652_DN
DrugAC1Q68Z5

KAT6B NCOA1 NCOA3 EP300 KAT6A

1.72e-05386205CID000000181
DrugAC1N0FHX

EP300 KAT6A

2.05e-058202CID003916227
DrugAC1LCVO8

KAT6B KAT6A

2.05e-058202CID000656891
DrugHydrochlorothiazide [58-93-5]; Down 200; 13.4uM; PC3; HT_HG-U133A

NIPAL3 SS18 NCOA3 CREB5

2.18e-051932046625_DN
DrugMS-275; Down 200; 10uM; PC3; HT_HG-U133A

KAT6B NCOA1 EP300 CLINT1

2.18e-051932047084_DN
DrugAlthiazide [5588-16-9]; Down 200; 10.4uM; HL60; HT_HG-U133A

NIPAL3 SS18 NCOA3 DCAF15

2.23e-051942042527_DN
Drug17-DMAG; Down 200; 0.1uM; HL60; HT_HG-U133A

KAT6B NCOA1 DCAF15 KAT6A

2.27e-051952046172_DN
DrugMevalonic-D, L acid lactone [674-26-0]; Down 200; 30.8uM; HL60; HT_HG-U133A

KAT6B SS18 DCAF15 CLINT1

2.32e-051962042718_DN
DrugOrlistat; Down 200; 10uM; MCF7; HT_HG-U133A

SS18 NCOA3 MLF2 BCL9

2.32e-051962046905_DN
DrugMuramic acid, N-acetyl [10597-89-4]; Up 200; 13.6uM; HL60; HT_HG-U133A

KAT6B SS18 NCOA1 NCOA3

2.32e-051962041326_UP
DrugTrichlorfon [52-68-6]; Down 200; 15.6uM; PC3; HT_HG-U133A

FOXA2 KAT6B SS18 NCOA3

2.41e-051982041797_DN
Druggalangin

NCOA1 NCOA3 EP300

2.80e-0568203ctd:C037032
DrugCoA group

KAT6B NCOA1 NCOA3 EP300 KAT6A

2.98e-05433205CID000000317
Drug2,3,4,7,8-pentachlorodibenzofuran

NCOA1 NCOA3 EP300

3.76e-0575203ctd:C038890
DrugA25618

KAT6B NCOA1 NCOA3 EP300 CREB5 KAT6A

3.98e-05777206CID000005562
Drug2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3

NCOA1 NCOA3

4.01e-0511202ctd:C061137
DrugC04424

KAT6B KAT6A

4.01e-0511202CID011953835
DrugB on A

KAT6B NCOA1 NCOA3 EP300 KAT6A

4.14e-05464205CID000007104
DrugC05118

KAT6B KAT6A

4.81e-0512202CID000440565
DrugC05119

KAT6B KAT6A

4.81e-0512202CID000440566
Drugdihydroxy-vitamin D3

NCOA1 NCOA3

5.68e-0513202ctd:C118756
DrugAC1L9EUB

KAT6B KAT6A

5.68e-0513202CID000443527
DrugAC1L9EU8

KAT6B KAT6A

6.63e-0514202CID000443526
DrugAC1LCVO5

KAT6B KAT6A

6.63e-0514202CID000656890
Drugferutinin

NCOA1 NCOA3

8.73e-0516202CID000354654
DrugAC1L9ASI

KAT6B KAT6A

9.89e-0517202CID000441230
DrugAC1L9DEH

KAT6B NCOA1 NCOA3 EP300 KAT6A

1.09e-04569205CID000442783
Drugmobs

NCOA1 EP300

1.68e-0422202CID003674064
Drugsodium butyrate

KAT6B NCOA1 EP300 KAT6A

2.05e-04344204CID005222465
DrugDihydrotestosterone

FOXA2 NCOA1 NCOA3 EP300

2.44e-04360204ctd:D013196
DrugLY117018

NCOA1 NCOA3

2.93e-0429202CID000104946
Drugtetrac

NCOA1 EP300

2.93e-0429202CID000065552
Drug3-hydroxyflavone

NCOA1 NCOA3

2.93e-0429202ctd:C041477
DrugLycorine hydrochloride [2188-68-3]; Up 200; 12.4uM; HL60; HT_HG-U133A

NCOA3 DCAF15 CREB5

3.12e-041532032195_UP
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

FOXA2 KAT6B DCAF15

4.25e-041702033791_DN
Drugirinotecan HCl; Down 200; 100uM; PC3; HT_HG-U133A

KAT6B NCOA1 NCOA3

4.32e-041712037535_DN
Drugkhellin

KAT6B NCOA3 KAT6A

4.32e-04171203CID000003828
Drugbutyrate

KAT6B NCOA1 NCOA3 EP300 KAT6A

4.36e-04767205CID000000264
DrugL-165041

NCOA1 EP300

4.54e-0436202CID006603901
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

KAT6B DCAF15 EP300

4.54e-041742035745_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

KAT6B SS18 EP300

4.54e-041742035065_DN
Drug2-methylbutyryl-CoA

KAT6B KAT6A

4.79e-0437202CID000000054
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

KAT6B SS18 EP300

4.86e-041782034184_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

KAT6B DCAF15 EP300

4.94e-041792036609_DN
DrugCaptopril [62571-86-2]; Down 200; 17.2uM; PC3; HT_HG-U133A

KAT6B NCOA3 PRPF40A

4.94e-041792034585_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

KAT6B DCAF15 EP300

5.02e-041802033688_DN
DrugCamptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; PC3; HT_HG-U133A

KAT6B EP300 KAT6A

5.02e-041802034541_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

KAT6B DCAF15 EP300

5.02e-041802036886_DN
Drugcystamine

NCOA1 PRPF40A EP300

5.10e-04181203CID000002915
DrugPicrotoxinin [17617-45-7]; Down 200; 13.6uM; HL60; HT_HG-U133A

SS18 NCOA3 CLINT1

5.70e-041882032161_DN
DrugNeostigmine bromide [114-80-7]; Down 200; 13.2uM; PC3; HT_HG-U133A

KAT6B NCOA3 PRPF40A

5.70e-041882036735_DN
DrugMS-275; Down 200; 10uM; PC3; HT_HG-U133A

KAT6B DCAF15 CLINT1

5.78e-041892037074_DN
DrugNocodazole [31430-18-9]; Down 200; 13.2uM; PC3; HT_HG-U133A

SS18 NCOA3 KAT6A

5.87e-041902037145_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

KAT6B SS18 DCAF15

5.87e-041902036709_DN
DrugDeptropine citrate [2169-75-7]; Down 200; 7.6uM; HL60; HT_HG-U133A

SS18 NCOA3 CLINT1

5.87e-041902033144_DN
DrugNitrofural [59-87-0]; Down 200; 20.2uM; PC3; HT_HG-U133A

FOXA2 SS18 DCAF15

5.96e-041912036721_DN
DrugMonobenzone [103-16-2]; Down 200; 20uM; PC3; HT_HG-U133A

SS18 DCAF15 CLINT1

6.05e-041922036713_DN
DrugBenfluorex hydrochloride [23642-66-2]; Down 200; 10.4uM; HL60; HT_HG-U133A

KAT6B SS18 CLINT1

6.05e-041922031266_DN
DrugQuercetine dihydrate [6151-25-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A

KAT6B CLINT1 KAT6A

6.15e-041932034846_DN
DrugTropicamide [1508-75-4]; Down 200; 14uM; PC3; HT_HG-U133A

NIPAL3 FOXA2 KAT6A

6.15e-041932034280_DN
DrugGSK-3beta Inhibitor VIII; Up 200; 10uM; PC3; HT_HG-U133A

SS18 NCOA3 CLINT1

6.15e-041932037097_UP
DrugEtifenin [63245-28-3]; Down 200; 12.4uM; HL60; HT_HG-U133A

KAT6B SS18 NCOA3

6.15e-041932032477_DN
Drugpaclitaxel; Down 200; 0.1uM; MCF7; HG-U133A

NCOA1 EP300 BCL9

6.24e-04194203640_DN
DrugEnalapril maleate [76095-16-4]; Down 200; 8.2uM; HL60; HT_HG-U133A

KAT6B NCOA1 NCOA3

6.24e-041942032397_DN
DrugBetazole hydrochloride; Up 200; 27uM; PC3; HT_HG-U133A

NIPAL3 EP300 BCL9

6.24e-041942031812_UP
DrugCaptopril [62571-86-2]; Down 200; 17.2uM; HL60; HG-U133A

KAT6B PRPF40A MLF2

6.24e-041942031988_DN
DrugMoroxidine hydrochloride [3160-91-6]; Down 200; 19.2uM; PC3; HT_HG-U133A

SS18 DCAF15 KAT6A

6.24e-041942036705_DN
DrugMethylprednisolone, 6-alpha [83-43-2]; Down 200; 10.6uM; PC3; HT_HG-U133A

FOXA2 EP300 BCL9

6.24e-041942037137_DN
Drug11-deoxy-16,16-dimethyl Prostaglandin E2; Down 200; 10uM; PC3; HT_HG-U133A

KAT6B SS18 KAT6A

6.24e-041942037538_DN
DrugKaempferol [520-18-3]; Down 200; 14uM; MCF7; HT_HG-U133A

KAT6B NCOA1 DCAF15

6.24e-041942037196_DN
DrugMebendazole [31431-39-7]; Down 200; 13.6uM; PC3; HT_HG-U133A

NIPAL3 SS18 BCL9

6.24e-041942033671_DN
DrugBufexamac [2438-72-4]; Up 200; 18uM; HL60; HT_HG-U133A

SS18 NCOA3 DCAF15

6.33e-041952032382_UP
DrugAtractyloside potassium salt [102130-43-8]; Down 200; 5uM; PC3; HT_HG-U133A

SS18 NCOA3 CREB5

6.33e-041952033695_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HG-U133A

KAT6B NCOA3 PRPF40A

6.33e-041952031785_DN
DrugTiaprofenic acid [33005-95-7]; Down 200; 15.4uM; MCF7; HT_HG-U133A

DCAF15 EP300 BCL9

6.33e-041952032852_DN
DrugEstradiol-17 beta [50-28-2]; Down 200; 14.6uM; MCF7; HT_HG-U133A

SS18 NCOA1 EP300

6.33e-041952035318_DN
DrugCisapride [81098-60-4]; Down 200; 8.6uM; PC3; HT_HG-U133A

SS18 DCAF15 CLINT1

6.33e-041952036706_DN
Drugtrichostatin A; Up 200; 0.1uM; HL60; HG-U133A

NIPAL3 NCOA1 NCOA3

6.33e-04195203364_UP
DrugBenfluorex hydrochloride [23642-66-2]; Down 200; 10.4uM; MCF7; HT_HG-U133A

KAT6B SS18 DCAF15

6.33e-041952035327_DN
DrugCefazolin sodium salt [27164-46-1]; Down 200; 8.4uM; PC3; HT_HG-U133A

NCOA1 EP300 BCL9

6.33e-041952037385_DN
Drugprochlorperazine dimaleate salt; Up 200; 10uM; HL60; HT_HG-U133A

SS18 NCOA1 NCOA3

6.33e-041952031156_UP
DrugPimethixene maleate [13187-06-9]; Down 200; 9.8uM; MCF7; HT_HG-U133A

KAT6B NCOA1 DCAF15

6.33e-041952037426_DN
DrugMetrizamide [31112-62-6]; Up 200; 5uM; HL60; HT_HG-U133A

KAT6B SS18 NCOA3

6.33e-041952031318_UP
DrugSulfamethazine sodium salt [1981-58-4]; Down 200; 13.4uM; MCF7; HT_HG-U133A

SS18 NCOA1 BCL9

6.43e-041962033422_DN
DrugFlurandrenolide [1524-88-5]; Down 200; 9.2uM; PC3; HT_HG-U133A

NIPAL3 FOXA2 SS18

6.43e-041962033679_DN
DrugOfloxacin [82419-36-1]; Down 200; 11uM; PC3; HT_HG-U133A

SS18 NCOA3 DCAF15

6.43e-041962033673_DN
DrugProxyphylline [603-00-9]; Up 200; 16.8uM; HL60; HT_HG-U133A

SS18 DCAF15 CREB5

6.43e-041962033115_UP
DiseaseProstatic Neoplasms

NIPAL3 SLC31A1 NCOA1 NCOA3 KAT6A ZIC2

2.44e-06616206C0033578
DiseaseMalignant neoplasm of prostate

NIPAL3 SLC31A1 NCOA1 NCOA3 KAT6A ZIC2

2.44e-06616206C0376358
Diseasebreast carcinoma (is_marker_for)

NCOA1 NCOA3 EP300

1.19e-0566203DOID:3459 (is_marker_for)
Diseaseprostate cancer (is_marker_for)

NCOA1 NCOA3 EP300

1.55e-04156203DOID:10283 (is_marker_for)
Diseaseleft ventricular structural measurement

KAT6B SS18

1.61e-0388202EFO_0008205
DiseaseAdenoid Cystic Carcinoma

EP300 KAT6A

2.08e-03100202C0010606
DiseaseSquamous cell carcinoma

NCOA3 EP300

3.17e-03124202C0007137
Diseasemood instability measurement

EP300 CELF4

3.37e-03128202EFO_0008475
Diseaseirritable bowel syndrome

EP300 CELF4

3.53e-03131202EFO_0000555
DiseaseMammary Neoplasms, Human

NCOA1 NCOA3 EP300

5.10e-03525203C1257931
DiseaseMammary Carcinoma, Human

NCOA1 NCOA3 EP300

5.10e-03525203C4704874
DiseaseMammary Neoplasms

NCOA1 NCOA3 EP300

5.15e-03527203C1458155
DiseaseMalignant neoplasm of breast

KAT6B NCOA1 NCOA3 EP300

5.30e-031074204C0006142
DiseaseBreast Carcinoma

NCOA1 NCOA3 EP300

5.45e-03538203C0678222
Diseaseanxiety

CREB5 CELF4

9.88e-03223202EFO_0005230
Diseaseneutrophil count, basophil count

NCOA1 CREB5

9.96e-03224202EFO_0004833, EFO_0005090

Protein segments in the cluster

PeptideGeneStartEntry
RMQHHMQQMQQGNMG

EP300

2226

Q09472
SMANGMNAVMMHGRS

RAB40C

226

Q96S21
MQMQMGMMGTQPYAQ

KAT6B

2021

Q8WYB5
AMSNGNMNTMGHMME

CREB5

246

Q02930
NMNTMGHMMEMMGSR

CREB5

251

Q02930
MDAMPGMQNMHDKGM

NIPAL3

336

Q6P499
LGNTPMMNQSMMGMN

CLINT1

566

Q14677
MMNQSMMGMNMNIGM

CLINT1

571

Q14677
MMGMNMNIGMSAAGM

CLINT1

576

Q14677
SVMPGMMMSHMSQAS

PRPF40A

106

O75400
MMMSHMSQASMQPAL

PRPF40A

111

O75400
TAQYPMQMQMGMMGS

KAT6A

1946

Q92794
MQMQMGMMGSQAYTQ

KAT6A

1951

Q92794
MMSMQGMMGPQQNIM

BCL9

1381

O00512
GMGQSMEMERMMQAH

BCL9L

701

Q86UU0
SRMMQEQMTGAAMAM

EMC3

196

Q9P0I2
HSHGGGDSSMMMMPM

SLC31A1

31

O15431
SANGMLMNMMMMSDE

DCAF15

161

Q66K64
FMDMFGMMNDMIGNM

MLF2

76

Q15773
GMMNDMIGNMEHMTA

MLF2

81

Q15773
GMNGMNTYMSMSAAA

FOXA2

36

Q9Y261
MNPMMAQMQMSSLQM

NCOA1

1331

Q15788
SMVHMNGSSGHMGQM

NCOA3

1391

Q9Y6Q9
HMGQMNMNPMPMSGM

NCOA3

1401

Q9Y6Q9
MQQMAGQMGMFNPMA

CELF4

241

Q9BZC1
PMGMMGQVNQGNHMM

SS18

231

Q15532
HNQYGPMNMNMGMNM

ZIC2

211

O95409
PMNMNMGMNMAAAAA

ZIC2

216

O95409