Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	7.14e-07	5	84	3	GO:0030156
GeneOntologyBiologicalProcess	transcription-coupled nucleotide-excision repair	ERCC2 ERCC6 UVSSA	7.66e-06	10	84	3	GO:0006283
HumanPheno	Testicular gonadoblastoma	DHX37 ZFPM2 MAP3K1	3.59e-05	11	32	3	HP:0000030
HumanPheno	Vanishing testis	DHX37 ZFPM2 MAP3K1	3.59e-05	11	32	3	HP:0012870
HumanPheno	Ovarian gonadoblastoma	DHX37 ZFPM2 MAP3K1	3.59e-05	11	32	3	HP:0000149
HumanPheno	Gonadal dysgenesis	ERCC2 DHX37 ZFPM2 MAP3K1	8.15e-05	38	32	4	HP:0000133
HumanPheno	Hypoplasia of the vagina	DHX37 ZFPM2 MAP3K1	1.19e-04	16	32	3	HP:0008726
HumanPheno	Primary gonadal insufficiency	DHX37 ZFPM2 MAP3K1	1.44e-04	17	32	3	HP:0008193
HumanPheno	Female external genitalia in individual with 46,XY karyotype	DHX37 ZFPM2 MAP3K1	1.44e-04	17	32	3	HP:0008730
HumanPheno	Urogenital sinus anomaly	DHX37 ZFPM2 MAP3K1	1.72e-04	18	32	3	HP:0100779
HumanPheno	Gonadoblastoma	DHX37 ZFPM2 MAP3K1	1.72e-04	18	32	3	HP:0000150
HumanPheno	Embryonal renal neoplasm	DHX37 BUB1 ZFPM2 MAP3K1	2.23e-04	49	32	4	HP:0011794
HumanPheno	Nephroblastoma	DHX37 BUB1 ZFPM2 MAP3K1	2.23e-04	49	32	4	HP:0002667
HumanPheno	Increased cellular sensitivity to UV light	ERCC6 UVSSA	2.28e-04	4	32	2	HP:0003224
HumanPheno	Abnormal sex determination	DHX37 ZFPM2 MAP3K1	2.77e-04	21	32	3	HP:0012244
Domain	FN3	RIMBP3 OBSL1 RIMBP3C RIMBP3B PTPRT MYBPC3	2.59e-04	199	83	6	PS50853
Domain	DUF3398	DOCK8 DOCK6	2.89e-04	6	83	2	PF11878
Domain	DOCK_C/D_N	DOCK8 DOCK6	2.89e-04	6	83	2	IPR021816
Domain	Glycos_transf_2	GALNTL6 GALNT14 B3GNTL1	3.15e-04	30	83	3	PF00535
Domain	Glyco_trans_2-like	GALNTL6 GALNT14 B3GNTL1	3.15e-04	30	83	3	IPR001173
Domain	FN3_dom	RIMBP3 OBSL1 RIMBP3C RIMBP3B PTPRT MYBPC3	3.37e-04	209	83	6	IPR003961
Domain	DOCK_C	DOCK8 DOCK6	1.05e-03	11	83	2	IPR010703
Domain	DHR-1_domain	DOCK8 DOCK6	1.05e-03	11	83	2	IPR027007
Domain	DHR_2	DOCK8 DOCK6	1.05e-03	11	83	2	PS51651
Domain	DHR_1	DOCK8 DOCK6	1.05e-03	11	83	2	PS51650
Domain	DOCK-C2	DOCK8 DOCK6	1.05e-03	11	83	2	PF14429
Domain	DHR-2	DOCK8 DOCK6	1.05e-03	11	83	2	IPR027357
Domain	DHR-2	DOCK8 DOCK6	1.05e-03	11	83	2	PF06920
Domain	DOCK	DOCK8 DOCK6	1.05e-03	11	83	2	IPR026791
Domain	FN3	OBSL1 RIMBP3C RIMBP3B PTPRT MYBPC3	1.40e-03	185	83	5	SM00060
Domain	SH3	RIMBP3 MATK RIMBP3C PLCG2 RIMBP3B	2.76e-03	216	83	5	SM00326
Domain	SH3	RIMBP3 MATK RIMBP3C PLCG2 RIMBP3B	2.76e-03	216	83	5	PS50002
Domain	SH3_domain	RIMBP3 MATK RIMBP3C PLCG2 RIMBP3B	2.99e-03	220	83	5	IPR001452
Domain	Cupredoxin	PRPF8 PADI1	4.25e-03	22	83	2	IPR008972
Domain	SH3_9	RIMBP3 RIMBP3C RIMBP3B	5.07e-03	78	83	3	PF14604
Domain	Ricin_B_lectin	GALNTL6 GALNT14	5.48e-03	25	83	2	PF00652
Domain	-	GALNTL6 GALNT14 B3GNTL1	5.63e-03	81	83	3	3.90.550.10
Domain	SH3_2	RIMBP3 RIMBP3C RIMBP3B	6.64e-03	86	83	3	IPR011511
Domain	SH3_2	RIMBP3 RIMBP3C RIMBP3B	6.64e-03	86	83	3	PF07653
Domain	RICIN	GALNTL6 GALNT14	6.84e-03	28	83	2	SM00458
Domain	RICIN_B_LECTIN	GALNTL6 GALNT14	6.84e-03	28	83	2	PS50231
Domain	FHA	KIF13B STARD9	6.84e-03	28	83	2	SM00240
Domain	Nucleotide-diphossugar_trans	GALNTL6 GALNT14 B3GNTL1	7.08e-03	88	83	3	IPR029044
Domain	Ricin_B_lectin	GALNTL6 GALNT14	7.83e-03	30	83	2	IPR000772
Domain	FHA	KIF13B STARD9	8.35e-03	31	83	2	PF00498
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	6.04e-08	4	87	3	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	1.51e-07	5	87	3	17855024
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	5.39e-06	14	87	3	17662146
Pubmed	The Cellular Response to Oxidatively Induced DNA Damage and Polymorphism of Some DNA Repair Genes Associated with Clinicopathological Features of Bladder Cancer.	ERCC2 ERCC6	6.19e-06	2	87	2	26649138
Pubmed	The Involvement of ERCC2/XPD and ERCC6/CSB Wild Type Alleles in Protection Against Aging and Cancer.	ERCC2 ERCC6	6.19e-06	2	87	2	28707579
Pubmed	KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR).	ERCC2 ERCC6 UVSSA	1.00e-05	17	87	3	22902626
Pubmed	Role of CCR2+ Myeloid Cells in Inflammation Responses Driven by Expression of a Surfactant Protein-C Mutant in the Alveolar Epithelium.	CCR2 SFTPC	1.85e-05	3	87	2	33968067
Pubmed	Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint.	BUB1 ESPL1	1.85e-05	3	87	2	19249208
Pubmed	An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria.	ERCC2 ERCC6	1.85e-05	3	87	2	16904611
Pubmed	The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.	WDR81 PLCG2 MYBPC3	2.95e-05	24	87	3	21822214
Pubmed	Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition.	ERCC2 ERCC6	3.70e-05	4	87	2	10416615
Pubmed	Fra-2-expressing macrophages promote lung fibrosis in mice.	SFTPC FOSL2	3.70e-05	4	87	2	31135379
Pubmed	p53 modulation of TFIIH-associated nucleotide excision repair activity.	ERCC2 ERCC6	3.70e-05	4	87	2	7663514
Pubmed	MEKK1 regulates the AP-1 dimer repertoire via control of JunB transcription and Fra-2 protein stability.	FOSL2 MAP3K1	3.70e-05	4	87	2	15558021
Pubmed	Transcription-coupled and global genome repair differentially influence UV-B-induced acute skin effects and systemic immunosuppression.	ERCC2 ERCC6	3.70e-05	4	87	2	10843671
Pubmed	High-order interactions among genetic polymorphisms in nucleotide excision repair pathway genes and smoking in modulating bladder cancer risk.	ERCC2 ERCC6	3.70e-05	4	87	2	17728339
Pubmed	[The polymorphism of DNA repair genes XPD, XRCC1, OGG1, and ERCC6, life expectancy, and the inclination to smoke].	ERCC2 ERCC6	3.70e-05	4	87	2	25731027
Pubmed	Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair.	ERCC6 UVSSA	3.70e-05	4	87	2	22466612
Pubmed	Nucleotide excision repair polymorphisms may modify ionizing radiation-related breast cancer risk in US radiologic technologists.	ERCC2 ERCC6	3.70e-05	4	87	2	18767034
Pubmed	Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice.	ERCC2 ERCC6	3.70e-05	4	87	2	16472827
Pubmed	[Association between nucleotide excision repair gene polymorphisms and chromosomal damage in coke-oven workers].	ERCC2 ERCC6	6.16e-05	5	87	2	17313739
Pubmed	Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology.	ERCC2 ERCC6	6.16e-05	5	87	2	22174697
Pubmed	Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia.	TBC1D1 MORC3	6.16e-05	5	87	2	23153538
Pubmed	Nucleotide excision repair gene polymorphisms and recurrence after treatment for superficial bladder cancer.	ERCC2 ERCC6	6.16e-05	5	87	2	15746040
Pubmed	Association between nucleotide excision repair gene polymorphisms and chromosomal damage in coke-oven workers.	ERCC2 ERCC6	6.16e-05	5	87	2	17438655
Pubmed	Polymorphisms in nucleotide excision repair genes and risk of multiple primary melanoma: the Genes Environment and Melanoma Study.	ERCC2 ERCC6	6.16e-05	5	87	2	16258177
Pubmed	The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.	ERCC2 ERCC6 UVSSA	6.46e-05	31	87	3	32355176
Pubmed	Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration.	SFTPC FOSL2	9.22e-05	6	87	2	34475534
Pubmed	USP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UV radiation-induced DNA damage.	ERCC6 UVSSA	9.22e-05	6	87	2	31775559
Pubmed	Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing.	ERCC2 ERCC6	9.22e-05	6	87	2	23562818
Pubmed	Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study.	ERCC2 ERCC6	9.22e-05	6	87	2	16399771
Pubmed	Modulation of nucleotide excision repair in human lymphocytes by genetic and dietary factors.	ERCC2 ERCC6	1.29e-04	7	87	2	19878615
Pubmed	Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk.	ERCC2 ERCC6	1.29e-04	7	87	2	16492920
Pubmed	Nucleotide excision repair pathway genes and oral premalignant lesions.	ERCC2 ERCC6	1.29e-04	7	87	2	17575242
Pubmed	Structural basis of human transcription-DNA repair coupling.	ERCC6 UVSSA	1.29e-04	7	87	2	34526721
Pubmed	Genetic variation in the nucleotide excision repair pathway and bladder cancer risk.	ERCC2 ERCC6	1.29e-04	7	87	2	16537713
Pubmed	A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy.	ERCC2 ERCC6	1.29e-04	7	87	2	10447254
Pubmed	Genetic susceptibility to esophageal cancer: the role of the nucleotide excision repair pathway.	ERCC2 ERCC6	1.72e-04	8	87	2	19270000
Pubmed	Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy.	CCR2 SFTPC	1.72e-04	8	87	2	28506464
Pubmed	Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein.	ERCC2 ERCC6	1.72e-04	8	87	2	8652557
Pubmed	Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice.	ERCC2 ERCC6	1.72e-04	8	87	2	9607915
Pubmed	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	CAD DHX37 PRPF8	1.86e-04	44	87	3	26471122
Pubmed	Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection.	CCR2 SFTPC	2.20e-04	9	87	2	33951416
Pubmed	Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects.	SFTPC ZFPM2	2.20e-04	9	87	2	17069789
Pubmed	High throughput RNAi screening identifies ID1 as a synthetic sick/lethal gene interacting with the common TP53 mutation R175H.	LMLN AP3B2 CTBS	2.56e-04	49	87	3	24378760
Pubmed	The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development.	SFTPC ZFPM2	2.75e-04	10	87	2	23836893
Pubmed	Nonsyndromic Disorders of Testicular Development Overview	DHX37 MAP3K1	2.75e-04	10	87	2	20301714
Pubmed	NEDD4L-mediated LTF protein degradation limits ferroptosis.	TMED8 STOML2	2.75e-04	10	87	2	32811647
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	ERCC2 TBC1D1 FKBP9 SENP2 RIMBP3C TUT1 CLHC1 MMACHC	3.37e-04	689	87	8	36543142
Pubmed	A pathway sensor for genome-wide screens of intracellular proteolytic cleavage.	TBC1D10A CYFIP2	4.02e-04	12	87	2	18387192
Pubmed	A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair.	ERCC2 ERCC6	4.74e-04	13	87	2	20541997
Pubmed	Interleukin-32α modulates promyelocytic leukemia zinc finger gene activity by inhibiting protein kinase Cɛ-dependent sumoylation.	TUT1 ZFPM2	4.74e-04	13	87	2	25178676
Pubmed	Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.	BUB1 IL17RA ESPL1	4.90e-04	61	87	3	27694478
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK8 DOCK6	5.52e-04	14	87	2	12432077
Pubmed	Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.	TLE2 MAFA	5.52e-04	14	87	2	17202186
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	STARD9 TBC1D1 MARK4 OBSL1 SENP2 YY1AP1	5.63e-04	407	87	6	12693553
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	CAD TUT1 PRPF8 CYFIP2	6.19e-04	154	87	4	16055720
Pubmed	Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy.	ERCC2 ERCC6	6.36e-04	15	87	2	18854777
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	RIMBP3 KIF13B CAD BUB1 OBSL1 YY1AP1 MORC3	6.93e-04	588	87	7	38580884
Pubmed	Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution.	ERCC2 ERCC6	7.26e-04	16	87	2	11313499
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	LINGO1 HMCN1 OBSL1 PTPRT	7.48e-04	162	87	4	25826454
Pubmed	Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.	CAPN13 GALNT14	8.21e-04	17	87	2	25102180
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	LNX2 DOCK8 TBC1D1 ECH1 DOCK6 CYFIP2	9.05e-04	446	87	6	24255178
Pubmed	Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons.	FOSL2 ZFPM2	9.22e-04	18	87	2	34161768
Pubmed	Binding specificity of Toll-like receptor cytoplasmic domains.	GLDC ECH1	1.03e-03	19	87	2	16482509
Pubmed	Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.	GALNT14 CYP7B1	1.14e-03	20	87	2	22174851
Pubmed	Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.	ERCC2 ERCC6 POLM	1.24e-03	84	87	3	19237606
Pubmed	Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development.	SFTPC ZFPM2	1.38e-03	22	87	2	25079229
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIF13B CEP112 STARD9 TBC1D1 MATK MARK4 MORC3 DOCK6	1.43e-03	861	87	8	36931259
Pubmed	Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.	WDR81 PRPF8	1.65e-03	24	87	2	20705733
Pubmed	Proteomic analysis of the cellular responses induced in uninfected immune cells by cell-expressed X4 HIV-1 envelope.	ECH1 STOML2	1.65e-03	24	87	2	17676665
Pubmed	Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice.	SFTPC AP3B2	1.65e-03	24	87	2	26178733
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	NBAS CAD PRPF8 DOCK6	1.69e-03	202	87	4	33005030
Pubmed	Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.	CCR2 IL15RA SFTPC IL17RA	1.75e-03	204	87	4	20503287
Pubmed	Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.	CCR2 IL15RA SFTPC IL17RA	1.78e-03	205	87	4	19258923
Pubmed	Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.	KIF13B STARD9	1.79e-03	25	87	2	9275178
Pubmed	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	CCR2 IL15RA SFTPC IL17RA	1.85e-03	207	87	4	17703412
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	KIF13B NBAS ERCC2 CAD DHX37 PRPF8 STOML2	1.95e-03	704	87	7	29955894
Pubmed	Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.	TBC1D10A TBC1D1	2.08e-03	27	87	2	22354992
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	KIF13B HECTD4 OBSL1	2.17e-03	102	87	3	9734811
Pubmed	Transcription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation.	ERCC6 SENP2 MORC3	2.17e-03	102	87	3	31722399
Pubmed	Novel interactors and a role for supervillin in early cytokinesis.	STARD9 BUB1	2.24e-03	28	87	2	20309963
Interaction	UBE2E1 interactions	RNF150 POLM MARCHF3 UVSSA TRIM29 TRIB1 MAP3K1	5.14e-06	164	83	7	int:UBE2E1
Cytoband	2p22-p21	CAPN13 CAD	9.87e-05	8	87	2	2p22-p21
Cytoband	Ensembl 112 genes in cytogenetic band chr2p23	CAPN13 GALNT14 CAD FOSL2	1.92e-04	149	87	4	chr2p23
GeneFamily	WD repeat domain containing\|ERCC excision repair associated	ERCC2 ERCC6	1.56e-04	7	50	2	1268
GeneFamily	Zinc fingers C2HC-type\|PHD finger proteins\|Lysine acetyltransferases	NANOS2 ZFPM2	8.77e-04	16	50	2	66
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	LINGO1 HMCN1 OBSL1 MYBPC3	1.01e-03	161	50	4	593
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNTL6 GALNT14	1.38e-03	20	50	2	433
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL15RA IL17RA	6.01e-03	42	50	2	602
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF13B STARD9	7.18e-03	46	50	2	622
GeneFamily	Basic leucine zipper proteins	FOSL2 MAFA	8.11e-03	49	50	2	506
ToppCell	cellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GALNT14 SYCP2L IL15RA LNX2 CEP112 WDR81	1.93e-06	189	87	6	bccb3481ffed597c845fe860da658505316105b5
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GALNTL6 SYCP2L STARD9 MARCHF3 MARK4 RYR3	2.12e-06	192	87	6	c0e59e642b42c055cf73d029cf54d07d9b719359
ToppCell	Control_saline-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	ATP13A4 SFTPC OBSL1 RBM47 TRIB1 CYFIP2	2.46e-06	197	87	6	44a59dfb889577b3160a5b13ada1276771a00241
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GALNT14 BUB1 TRIM29 ESPL1 PTPRT PADI1	2.53e-06	198	87	6	f088badb90c6c2d916195f5649eda102119c9ac6
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GALNT14 ATP13A4 CEP112 PTPRT RYR3	5.28e-06	128	87	5	e100629f6038e32176ffcc81bd06bd175df46cef
ToppCell	VE-CD8-memory_CD4\|VE / Condition, Cell_class and T cell subcluster	CCR2 HMCN1 MATK CELF2-AS1 RYR3	1.22e-05	152	87	5	9401b7770c1bdc87eba25e82922f5dd1c4fa37ee
ToppCell	Basal_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	CAPN13 GALNT14 HMCN1 AP3B2 TRIM29	1.47e-05	158	87	5	51e3ed1b91b010404d66e3e7efdbffc0c815e25b
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCR2 MATK IL17RA PLCG2 CYFIP2	1.51e-05	159	87	5	cdbccb83af6220bab300dfe56443ff69f6e2043a
ToppCell	facs-Lung-EPCAM-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK8 IL17RA PLCG2 CLHC1 CYFIP2	1.66e-05	162	87	5	484ea4ac40de672dcbd2583a52cb7f385c918814
ToppCell	facs-Lung-EPCAM-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK8 IL17RA PLCG2 CLHC1 CYFIP2	1.66e-05	162	87	5	bba144ac5332bab9eba2ccf599703c781a7f88f1
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LINGO1 CEP112 STARD9 ANKS3 RYR3	2.03e-05	169	87	5	16c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCell	facs-Lung-18m-Hematologic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CCR2 DOCK8 IL17RA PLCG2 CYFIP2	2.67e-05	179	87	5	62fd60963203a3db98c83b19292c40cc4421cd94
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ATP13A4 SFTPC GLDC RBM47 CYFIP2	3.30e-05	187	87	5	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	GLDC BUB1 ESPL1 RBM47 CYFIP2	3.74e-05	192	87	5	25378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell	Children_(3_yrs)-Immune-monocyte-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CCR2 DOCK8 TBC1D1 IL17RA MAP3K1	3.83e-05	193	87	5	58e1930a1d80ad3729ab9604ac8ebf7308232a3d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYCP2L STARD9 MARCHF3 MARK4 DOCK6	4.12e-05	196	87	5	ab7be3858deabbd1fc44e8b9da8ff49a50bf1fb1
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-B-Plasmablast\|ICU-NoSEP / Disease, condition lineage and cell class	GALNT14 SCMH1 GLDC FAM209B BUB1	4.22e-05	197	87	5	8f35f9741086a38f0e594dce0547b575946f52bb
ToppCell	Control_saline-Epithelial_alveolar-AT_2\|Control_saline / Treatment groups by lineage, cell group, cell type	SFTPC OBSL1 RBM47 TRIB1 CYFIP2	4.22e-05	197	87	5	b8f62fcd6eb8f47b3cc41f616126f82c68a36e87
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYCP2L STARD9 MARCHF3 DOCK6 RYR3	4.33e-05	198	87	5	0a172c6d997c7cfbad34b56e80121bd104dee67d
Disease	UV-sensitive syndrome (is_implicated_in)	ERCC6 UVSSA	2.28e-05	3	82	2	DOID:0060240 (is_implicated_in)
Disease	UV-Sensitive Syndrome	ERCC6 UVSSA	2.28e-05	3	82	2	C1833561
Disease	Cerebrooculofacioskeletal Syndrome 1	ERCC2 ERCC6	4.56e-05	4	82	2	C0220722
Disease	Cockayne syndrome (implicated_via_orthology)	ERCC2 ERCC6	1.14e-04	6	82	2	DOID:2962 (implicated_via_orthology)
Disease	Gonadal Dysgenesis, 46,XY	ZFPM2 MAP3K1	2.11e-04	8	82	2	C0018054
Disease	eye movement measurement	CAPN13 GALNT14	2.11e-04	8	82	2	EFO_0007699
Disease	Dickkopf-related protein 4 measurement	CEP112 ZFPM2	2.11e-04	8	82	2	EFO_0008110
Disease	thrombin generation potential measurement	SYCP2L MYBPC3	4.13e-04	11	82	2	EFO_0005538
Disease	46,XY partial gonadal dysgenesis	ZFPM2 MAP3K1	4.13e-04	11	82	2	C4510744
Disease	coronary artery disease	DOCK8 MARK4 HECTD4 AS3MT GRIFIN PLCG2 DOCK6 RBM47 TRIB1 ZFPM2 MAP3K1	4.58e-04	1194	82	11	EFO_0001645
Disease	C-reactive protein measurement	ERCC2 CAD LINGO1 TBC1D1 FOSL2 MARK4 TRIB1 ZFPM2 MAP3K1 CYFIP2 MYBPC3	4.98e-04	1206	82	11	EFO_0004458
Disease	apolipoprotein B measurement	KIF13B NANOS2 ERCC2 MARK4 WDR81 DOCK6 RBM47 TRIB1	5.15e-04	663	82	8	EFO_0004615
Disease	glycerate measurement	HMCN1 RYR3	7.82e-04	15	82	2	EFO_0021029
Disease	venous thromboembolism, fibrinogen measurement	HECTD4 PLCG2 ZFPM2	8.72e-04	67	82	3	EFO_0004286, EFO_0004623
Disease	stomach cancer (is_implicated_in)	ERCC2 ERCC6 MAP3K1	1.07e-03	72	82	3	DOID:10534 (is_implicated_in)
Disease	drug-Induced dyskinesia, response to levodopa	CAPN13 GALNT14	1.13e-03	18	82	2	EFO_0010747, EFO_1000904
Disease	Age-related macular degeneration	ERCC6 HMCN1	1.13e-03	18	82	2	cv:C0242383
Disease	phosphatidylethanolamine measurement	SYCP2L WDR81 PLCG2 RYR3	1.40e-03	173	82	4	EFO_0010228
Disease	Moderate albuminuria	AS3MT TRIB1 PTPRT	1.46e-03	80	82	3	HP_0012594
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	PLCG2 ZFPM2	1.55e-03	21	82	2	EFO_0004286, EFO_0004792
Disease	lung disease (is_marker_for)	CCR2 SFTPC	1.70e-03	22	82	2	DOID:850 (is_marker_for)
Disease	cardiovascular disease	TBC1D1 FOSL2 GRIFIN TRIB1 ZFPM2 MYBPC3	1.73e-03	457	82	6	EFO_0000319
Disease	venous thromboembolism, tissue plasminogen activator measurement	PLCG2 ZFPM2	1.86e-03	23	82	2	EFO_0004286, EFO_0004791
Disease	interstitial lung disease (is_marker_for)	CCR2 SFTPC	2.20e-03	25	82	2	DOID:3082 (is_marker_for)
Disease	macular degeneration (is_marker_for)	CCR2 ERCC6	2.37e-03	26	82	2	DOID:4448 (is_marker_for)
Disease	Agents acting on the renin-angiotensin system use measurement	TBC1D1 FOSL2 GRIFIN TRIB1 MYBPC3	2.45e-03	335	82	5	EFO_0009931
Disease	hip circumference	HMCN1 DOCK8 DHX37 SENP2 PTPRT	2.54e-03	338	82	5	EFO_0005093
Disease	reticulocyte measurement	MARCHF3 MARK4 HECTD4 FKBP9 GRIFIN PLCG2 PRPF8 TRIB1 MAP3K1	2.58e-03	1053	82	9	EFO_0010700
Disease	triglyceride measurement, alcohol drinking	FOSL2 TRIB1 MYBPC3	2.68e-03	99	82	3	EFO_0004329, EFO_0004530
Disease	stimulant use measurement	NBAS ATP13A4	2.75e-03	28	82	2	EFO_0600076

Protein segments in the cluster

Peptide	Gene	Start	Entry
GECKPEGLFRRLPHL	BUB1	1011	O43683
PNIECVPHLIKEGRA	ATP13A4	881	Q4VNC1
PFVLKLPHRTERQRC	CEP112	26	Q8N8E3
PVQGDKCLFVRPRHQ	CAPN13	146	Q6MZZ7
DHVCTIAKVPFRGAP	CTBS	266	Q01459
TPKCHLKRRIQPAFG	ERCC6	1031	Q03468
YCEHVPRIAPDVLRK	AP3B2	511	Q13367
PVECRHRLEVAGPRK	POLM	116	Q9NP87
HPQRGCEVFVGKIPR	RBM47	66	A0AV96
GEIHCGTNVRRKPFP	PADI1	641	Q9ULC6
GFIHLRTECGPRKEP	RIMBP3B	1326	A6NNM3
GFIHLRTECGPRKEP	RIMBP3C	1326	A6NJZ7
GRLPCKQIIHAVGPR	PARP9	186	Q8IXQ6
CRHPPREKTVLVGRR	OBSL1	1811	O75147
KLACRPFHPKRDGFV	OXSM	261	Q9NWU1
RGAPVRLRCDHGKPV	IL17RA	461	Q96F46
KCEHTRPKPGELAFR	MATK	56	P42679
VKKEPPEAERFCHRL	MAFA	31	Q8NHW3
LKCIRDPALVHQRPA	IL15RA	91	Q13261
CLLRVGVFRPCHVRP	CELF2-AS1	116	Q8N7Q2
PRCDIFPGIVSKHLE	ZFPM2	786	Q8WW38
PRVVEEARKHFDCPV	LMLN	346	Q96KR4
VPPHGCLARDGRIKR	LNX2	501	Q8N448
PRGIRLSALCPKFLH	MORC3	6	Q14149
EPQGKVPCGEHFRIR	FAM209B	31	Q5JX69
IERCPKPVIAAVHGG	ECH1	156	Q13011
GPGVRPRLCHIVKDE	PDZD3	216	Q86UT5
CIHPEVTPLRFGKDV	ERCC2	116	P18074
LCHRKRFVAVPEGIP	LINGO1	56	Q96FE5
RHLPKLGRSIACPFV	PLCG2	1071	P16885
NFVGPPHFKTICRLL	CYFIP2	931	Q96F07
EGIATVRFPPIDCRK	HECTD4	1771	Q9Y4D8
PRKPHDCVPTRADRI	MMACHC	176	Q9Y4U1
VPFLHRCEKQSPGVA	NBAS	936	A2RRP1
LKTPDGVVVCPILRH	NANOS2	81	P60321
TRKRLCDHPVPVKGG	HMCN1	4836	Q96RW7
EVRVLAHPCRKAPHF	PTPRT	181	O14522
VPCSRVGHVFRKKHP	GALNT14	326	Q96FL9
CIGEKRRIVVPPHLG	FKBP9	326	O95302
CHGVRRPPFSIDLFK	CFAP119	176	A1A4V9
PEVPPEKLHRCFRLQ	ESPL1	496	Q14674
EPPREHFGQRILVKC	DOCK6	251	Q96HP0
VPECPKEHLGNRILV	DOCK8	256	Q8NF50
AHGPVCKISPEERRS	FOSL2	186	P15408
GCVTTARPVPKHIRE	AS3MT	31	Q9HBK9
FHIALGCRIAPLQKP	CCR2	316	P41597
CHFRFAVERKPRPLV	MARCHF3	116	Q86UD3
HFEVEVCQLPRPGLR	MARK4	711	Q96L34
RPCRKKGVSIHEGPR	ANKS3	256	Q6ZW76
CVRKGDLVAIFPPVL	CYP7B1	386	O75881
HKVLQFPCRQRPLGA	GRIFIN	101	A4D1Z8
RVQCPALIVHGEKDP	BPHL	231	Q86WA6
EVHALCRRLRKAFPP	DHX37	481	Q8IY37
FKLSCRAVGVHPPLE	CFAP74	1006	Q9C0B2
RGRFGIPCCPVHLKR	SFTPC	21	P11686
KPNDVVRILPCRHLF	RNF150	286	Q9ULK6
VSKHRLQGFIPCRIP	MAP3K1	1001	Q13233
IRPGEPLHTRKFCFD	GALNTL6	506	Q49A17
IGCVKVRPLRAPRTH	KIF13B	1056	Q9NQT8
PAKRPRLDCFIHQVK	SENP2	46	Q9HC62
PIRDFEARKCPVHGK	TRIM29	216	Q14134
DRLKCPFHGKIVPRD	UVSSA	581	Q2YD98
CRIHRIPFRPKSGDG	SLC6A16	681	Q9GZN6
GFIHLRTECGPRKEP	RIMBP3	1326	Q9UFD9
EVCRAGSKHSRPIPL	STARD9	2886	Q9P2P6
VDRKNPHFICPATIG	SCMH1	176	Q96GD3
HFRAARPPFVICVKL	B3GNTL1	321	Q67FW5
IRKHAVLPPIICRSD	CLHC1	6	Q8NHS4
YREHCPAGQPVKVRV	PRPF8	431	Q6P2Q9
IRRGQFCIPEHISPK	TRIB1	296	Q96RU8
VVVKLLIRRPECFGP	RYR3	2216	Q15413
VPSARRPVVKFCHRP	TUT1	361	Q9H6E5
CILHAVPREERKKFP	SYCP2L	191	Q5T4T6
LFCGRVTVAHKKAPP	TBC1D1	176	Q86TI0
LLALCHVDGRVPFRP	SLC35A4	36	Q96G79
RCLRYEIKDIHVPPR	STOML2	171	Q9UJZ1
PQPGAVELAAKHCRR	CAD	2026	P27708
GARAFRCIKPAPVIH	YY1AP1	581	Q9H869
GHLSPVRIPCLRGKF	nan	41	Q8N9G6
HVNEKIPRPTCIGDR	ZNF18	276	P17022
CRSPPRLHGAKAILD	TBC1D10A	381	Q9BXI6
GKVPICIPARRDLVD	TLE2	256	Q04725
APFLCERLHIKVIPT	TXNDC9	131	O14530
DHFRAFKPLGKVPCR	WDR87	96	Q6ZQQ6
QAVRGLCTRHPKEVP	WDR81	801	Q562E7
VTIRVPTHPEGKRVC	TMED8	191	Q6PL24
RRKFLVDPRCHPQTI	GLDC	216	P23378
KIHLDCPGRIPDTIV	MYBPC3	646	Q14896
CVKPDVHVYRIPPRA	NECAP2	11	Q9NVZ3