Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionneuropilin binding

TAOK2 VEGFA

4.73e-055442GO:0038191
GeneOntologyMolecularFunctionATPase-coupled inorganic anion transmembrane transporter activity

ABCC9 ABCC10

2.11e-0410442GO:0043225
GeneOntologyMolecularFunctionATP-dependent activity

SHPRH NAV3 UBA6 DNHD1 ABCC9 MDN1 ABCC10

3.58e-04614447GO:0140657
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC6A8 ABCC9 TTYH3 ABCC10

5.40e-04171444GO:0015103
GeneOntologyMolecularFunctionxenobiotic transmembrane transporter activity

SLC43A3 ABCC10

2.55e-0334442GO:0042910
GeneOntologyBiologicalProcesspositive regulation of protein autophosphorylation

TAOK2 NEK10 VEGFA

3.41e-0529453GO:0031954
DomainAAA+_ATPase

NAV3 ABCC9 MDN1 ABCC10

3.62e-04144444IPR003593
DomainAAA

NAV3 ABCC9 MDN1 ABCC10

3.62e-04144444SM00382
DomainABC_membrane

ABCC9 ABCC10

1.45e-0324442PF00664
DomainABC_TM1F

ABCC9 ABCC10

1.97e-0328442PS50929
DomainABC1_TM_dom

ABCC9 ABCC10

1.97e-0328442IPR011527
Domain7TM_GPCR_Srsx

GPR19 GALR1 OR56B1

2.32e-03112443SM01381
DomainP-loop_NTPase

SHPRH NAV3 DNHD1 ABCC9 MDN1 ABCC10 IQCB1

3.42e-03848447IPR027417
DomainABC_transporter_CS

ABCC9 ABCC10

4.40e-0342442IPR017871
DomainGPCR_Rhodpsn_7TM

GPBAR1 TAS2R42 GPR19 GALR1 OR56B1 OR56B4

4.61e-03670446IPR017452
DomainG_PROTEIN_RECEP_F1_2

GPBAR1 TAS2R42 GPR19 GALR1 OR56B1 OR56B4

5.35e-03691446PS50262
DomainGPCR_Rhodpsn

GPBAR1 TAS2R42 GPR19 GALR1 OR56B1 OR56B4

5.38e-03692446IPR000276
DomainABC_TRANSPORTER_2

ABCC9 ABCC10

5.71e-0348442PS50893
DomainABC_tran

ABCC9 ABCC10

5.71e-0348442PF00005
DomainABC_TRANSPORTER_1

ABCC9 ABCC10

5.95e-0349442PS00211
DomainABC_transporter-like

ABCC9 ABCC10

6.18e-0350442IPR003439
Domain-

SHPRH NAV3 DNHD1 ABCC9 MDN1 ABCC10

7.70e-037464463.40.50.300
DomainS_TKc

TAOK2 PKMYT1 NEK10 RPS6KA3

9.95e-03359444SM00220
DomainProtein_kinase_ATP_BS

TAOK2 PKMYT1 NEK10 RPS6KA3

1.20e-02379444IPR017441
DomainPkinase

TAOK2 PKMYT1 NEK10 RPS6KA3

1.22e-02381444PF00069
Pubmed

GANP suppresses the arginine methyltransferase PRMT5 regulating IL-4-mediated STAT6-signaling to IgE production in B cells.

CD19 MCM3AP

1.87e-06248219181385
Pubmed

Significance of glycosylphosphatidylinositol-anchored protein enrichment in lipid rafts for the control of autoimmunity.

PGAP3 CD19

1.87e-06248223864655
Pubmed

Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses.

CD19 MCM3AP

1.87e-06248214715907
Pubmed

Integrity of immunoglobulin variable regions is supported by GANP during AID-induced somatic hypermutation in germinal center B cells.

CD19 MCM3AP

1.87e-06248228541550
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TAOK2 PKMYT1 CCDC142 SLC6A8 TTYH3 PGAP3 MDN1 ABCC10 MCM3AP CTDP1

2.20e-061105481035748872
Pubmed

GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.

CD19 MCM3AP

5.59e-06348220507984
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

TTC27 MDN1 MCM3AP CTDP1

1.33e-0510448431240132
Pubmed

Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain.

PGAP3 MPPE1

1.86e-05548229374258
Pubmed

Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions.

TPO VEGFA

5.19e-05848221149635
Pubmed

GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.

CD19 MCM3AP

1.02e-041148223652018
Pubmed

Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation.

TPO VEGFA

3.85e-042148223707896
Pubmed

Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.

ABCC9 ABCC10

4.63e-042348210708515
Pubmed

The MEV mouse linkage testing stock: mapping 30 novel proviral insertions and establishment of an improved stock.

TPO H6PD

6.40e-04274828390965
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

TAOK2 SYNJ2 MCM3AP

7.80e-0413048312421765
Pubmed

Novel loci regulating bone anabolic response to loading: expression QTL analysis in C57BL/6JXC3H/HeJ mice cross.

GALR1 VEGFA

1.27e-033848217543594
Cytoband18q23

GALR1 CTDP1

4.27e-042948218q23
CytobandEnsembl 112 genes in cytogenetic band chr18q23

GALR1 CTDP1

8.14e-0440482chr18q23
Cytoband11p15.4

DNHD1 OR56B1 OR56B4

1.22e-0320048311p15.4
GeneFamilyOlfactory receptors, family 56

OR56B1 OR56B4

1.02e-049312167
GeneFamilyATP binding cassette subfamily C

ABCC9 ABCC10

2.19e-0413312807
ToppCell368C-Fibroblasts-Fibroblast-E|368C / Donor, Lineage, Cell class and subclass (all cells)

PKMYT1 NAV3 GPR19 ZSWIM1 ABI3BP

8.60e-07162485e17632778a57c71d6005d3abca3a0443a92040e7
ToppCell368C-Fibroblasts-Fibroblast-E-|368C / Donor, Lineage, Cell class and subclass (all cells)

PKMYT1 NAV3 GPR19 ZSWIM1 ABI3BP

8.60e-07162485ac4a80fd72c9311ea2b3e574c6284bbce4f2756c
ToppCellLPS-IL1RA-Stromal_mesenchymal-Fibroblasts|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC6A8 PGAP3 ABI3BP SYNJ2

1.85e-0514648486cddd0e7f954547b7ffdccb0329cd5c4b725ac1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PKMYT1 MMS22L LMF2 GPR19

2.40e-05156484955547dfeb1b1ad4957b4338701055726b22619f
ToppCellLPS-IL1RA-Stromal_mesenchymal-Fibroblasts-Pericyte_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNHD1 ABI3BP SYNJ2 NEK10

2.53e-051584847f5426585d0d299d2b48e5fcb349950feffdef33
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

PKMYT1 MMS22L CD19 NEK10

3.06e-05166484f4698fd08965936d51695d571bd10fb77330d916
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

PKMYT1 MMS22L CD19 NEK10

3.52e-05172484e9b97f37bb1732ad9aa89c5e9b513d14022801ac
ToppCellCOVID-19_Mild-PLT_2|COVID-19_Mild / Disease Group and Platelet Clusters

TTC27 DNHD1 PGAP3 MCM3AP

3.60e-05173484d11705e56b6b21eec963ea224717f27680c781ed
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TPO LINC00299 ABCC9 SYNJ2

3.94e-05177484921783ed0fe20294d2f384d9136924b679df01bb
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TPO LINC00299 ABCC9 SYNJ2

4.11e-05179484445eeb0356d9fd894aa33dd9f45d893b21424149
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NAV3 CYP4X1 ABCC9 ABI3BP

5.18e-05190484efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PIDD1 MMS22L ZSWIM1 SYNJ2

5.18e-051904843f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC43A3 H6PD ABI3BP VEGFA

5.29e-0519148444a9a6768084dafc641ad455b65862bfd4cc0cb9
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PIDD1 MMS22L ZSWIM1 SYNJ2

5.40e-05192484c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MXRA5 ABI3BP DHCR7 VEGFA

6.20e-051994848b86c69aaf60feff53aa782559cfece7342a23de
ToppCelldistal-Hematologic-EREG+_Dendritic-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TTYH3 CD19 MBOAT4 VEGFA

6.33e-052004847809c74a2e52768854b66a135522138281bc4449
ToppCell(5)_Fibroblast-E|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

NAV3 ABCC9 MXRA5 ABI3BP

6.33e-0520048475e5ecb05e965e24d569aa2ef5cdf740b1528c06
Diseaseglomerulonephritis (is_implicated_in)

TPO VEGFA

1.13e-0411432DOID:2921 (is_implicated_in)
Diseasegallstones

GPBAR1 SYNJ2 VEGFA

5.29e-04108433EFO_0004210
DiseaseDepressive Symptoms

ABCC9 SYNJ2

6.59e-0426432C0086132
DiseasePapillary Renal Cell Carcinoma

NAV3 DNHD1 PIDD1

8.67e-04128433C1306837
DiseaseRenal Cell Carcinoma

NAV3 DNHD1 PIDD1

8.67e-04128433C0007134
DiseaseSarcomatoid Renal Cell Carcinoma

NAV3 DNHD1 PIDD1

8.67e-04128433C1266043
DiseaseChromophobe Renal Cell Carcinoma

NAV3 DNHD1 PIDD1

8.67e-04128433C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

NAV3 DNHD1 PIDD1

8.67e-04128433C1266044
Diseaseintellectual disability (is_implicated_in)

SLC6A8 RPS6KA3

8.79e-0430432DOID:1059 (is_implicated_in)
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

NAV3 DNHD1 PIDD1

1.32e-03148433C0279702
Diseasechildhood onset asthma

LINC00299 PGAP3 ABI3BP SYNJ2

1.41e-03334434MONDO_0005405
Diseaseosteoarthritis, knee, body mass index

TAOK2 VEGFA

1.64e-0341432EFO_0004340, EFO_0004616

Protein segments in the cluster

PeptideGeneStartEntry
LLGVQHWLHLWRPQT

LINC00299

36

Q6ZSB3
GHLHVVNPDWLWSCL

CTDP1

701

Q9Y5B0
PHLVSWHSWVGALTL

CYB561D1

121

Q8N8Q1
LLSWLPFHVAQLWHP

GPR19

286

Q15760
NTWLHFPGHNLRWIL

ABCC9

61

O60706
HRLLHQSLIWSWDQG

CCDC142

356

Q17RM4
LYCWAPWVQTHLHLD

DNHD1

111

Q96M86
WLLTHLLWFANAHLL

DHCR7

151

Q9UBM7
LLWFANAHLLSWFSP

DHCR7

156

Q9UBM7
AWISHSLALWVLAHS

ABCC10

111

Q5T3U5
VDAPGLALLALHWHW

MDN1

2736

Q9NU22
LLFASLPALGWNHWT

GPBAR1

136

Q8TDU6
PSWHLLHLHLDIHWL

MMS22L

206

Q6ZRQ5
ALVLRHPWIVHWDQL

RPS6KA3

671

P51812
LLPHLHWNAPEHLAW

MCM3AP

1646

O60318
LWWLQPRLVLSGHTH

MPPE1

291

Q53F39
HSDHLKLLWSIVWIL

NEK10

301

Q6ZWH5
GLWLHQAFFSPWTLL

TPO

516

P07202
WIPKTWHHLNSFLET

NAV3

2216

Q8IVL0
FILLGFPGIHSWQHW

OR56B1

21

Q8NGI3
FPGIHSWQHWLSLPL

OR56B1

26

Q8NGI3
FPGIHSWQHWLSLPL

OR56B2P

26

Q8NGI1
IHEWQHWLSLPLTLL

OR56B4

26

Q8NH76
FGISWLPHHIIHLWA

GALR1

256

P47211
HLEITARPVLWHWLL

CD19

271

P15391
VVLSIWGLHHNPAVW

CYP4X1

406

Q8N118
LHWLWAASSALFPSI

HYAL3

231

O43820
LHPRHSFWALSWRGL

MBOAT4

196

Q96T53
QAHLTTLKHIQAPWW

IQCB1

551

Q15051
NSLVAHTKPVWWSLH

ESRG

16

Q1W209
ASWNFWTPLLESLAH

H6PD

481

O95479
LWAHCQVPHFSWFLV

PIDD1

436

Q9HB75
PLFWVLDAHAIWHIS

PGAP3

276

Q96FM1
IAHFPHSLFLWLRWR

TAS2R42

111

Q7RTR8
WNLLHHPKLLNNTWL

SYNJ2

1416

O15056
TPRSWNFLHTLSWVL

SAMD8

316

Q96LT4
TPAAWFAHHLPVWLH

LMF2

211

Q9BU23
HSNSPWWLNVIHRAI

SHPRH

1136

Q149N8
HLPPWAIHTLASWGL

TAOK2

1171

Q9UL54
WHLVWLSVIQLWHYL

SLC43A3

281

Q8NBI5
WQHLTQPIWGLHHLE

SLC6A8

591

P48029
VHWLSWTAQGFLSPL

UBA6

376

A0AVT1
CWLWHGLAHPASWLQ

PKMYT1

391

Q99640
FWTRLHLIHFWNVLL

TTC41P

756

Q6P2S7
LFVLSSPHWWLHLAQ

TPTE2P1

81

Q5T6R2
LPELHSHWLLNDRIW

ZSWIM1

226

Q9BR11
SWVHWSLALLLYLHH

VEGFA

6

P15692
FLSWGFLINPHHDWT

ABI3BP

131

Q7Z7G0
LPWWTLRCVNIHQHL

TTC27

181

Q6P3X3
YAAPWWVSLLHRLPH

TTYH3

6

Q9C0H2
WVSLLHRLPHFDLSW

TTYH3

11

Q9C0H2
HWGALSVVLILLWGH

MXRA5

6

Q9NR99