Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	IgG receptor activity	FCGR2C FCGR2A FCGR2B	3.83e-06	7	97	3	GO:0019770
GeneOntologyMolecularFunction	IgG binding	FCGR2C FCGR2A FCGR2B	1.78e-05	11	97	3	GO:0019864
GeneOntologyMolecularFunction	immunoglobulin receptor activity	FCGR2C FCGR2A FCGR2B	3.89e-05	14	97	3	GO:0019763
GeneOntologyMolecularFunction	calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity	PDE1C PDE1B	6.98e-05	3	97	2	GO:0048101
GeneOntologyMolecularFunction	calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity	PDE1C PDE1B	6.98e-05	3	97	2	GO:0004117
GeneOntologyMolecularFunction	Toll-like receptor 2 binding	TLR6 TLR1	1.39e-04	4	97	2	GO:0035663
GeneOntologyMolecularFunction	beta-adrenergic receptor kinase activity	GRK2 GRK3	1.39e-04	4	97	2	GO:0047696
GeneOntologyMolecularFunction	low-affinity IgG receptor activity	FCGR2A FCGR2B	1.39e-04	4	97	2	GO:0019772
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE1C PDE1B PDE11A	1.60e-04	22	97	3	GO:0004115
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE1C PDE1B PDE11A	2.09e-04	24	97	3	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE1C PDE1B PDE11A	2.36e-04	25	97	3	GO:0004114
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE1C PDE1B PDE11A	2.99e-04	27	97	3	GO:0004112
GeneOntologyMolecularFunction	G protein-coupled receptor kinase activity	GRK2 GRK3	4.83e-04	7	97	2	GO:0004703
GeneOntologyMolecularFunction	immunoglobulin binding	FCGR2C FCGR2A FCGR2B	7.06e-04	36	97	3	GO:0019865
GeneOntologyMolecularFunction	calcium ion binding	FLG CLSTN3 TRPM2 HRNR FLG2 FAT2 ARSA EML1 PLCH1 PCDH10 MEX3B	1.02e-03	749	97	11	GO:0005509
GeneOntologyMolecularFunction	lipopeptide binding	TLR6 TLR1	1.02e-03	10	97	2	GO:0071723
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	PDE1C PDE1B PLCH1 PDE11A	1.28e-03	97	97	4	GO:0008081
GeneOntologyMolecularFunction	alpha-catenin binding	PKP3 PKP2	1.49e-03	12	97	2	GO:0045294
GeneOntologyMolecularFunction	amyloid-beta binding	CLSTN3 TLR6 FCGR2A FCGR2B	1.55e-03	102	97	4	GO:0001540
GeneOntologyMolecularFunction	arylsulfatase activity	ARSA ARSF	2.05e-03	14	97	2	GO:0004065
GeneOntologyMolecularFunction	NAD+ nucleotidase, cyclic ADP-ribose generating	TLR6 TLR1	2.68e-03	16	97	2	GO:0061809
GeneOntologyMolecularFunction	sulfuric ester hydrolase activity	ARSA ARSF	3.03e-03	17	97	2	GO:0008484
GeneOntologyMolecularFunction	cell-cell adhesion mediator activity	CLSTN3 PKP3 PKP2	3.26e-03	61	97	3	GO:0098632
GeneOntologyMolecularFunction	magnesium ion transmembrane transporter activity	MAGT1 SLC41A2	3.40e-03	18	97	2	GO:0015095
GeneOntologyMolecularFunction	serine-type peptidase activity	TPSD1 PCSK6 PCSK7 ENDOU IMMP2L	3.40e-03	207	97	5	GO:0008236
GeneOntologyBiologicalProcess	negative regulation of type I hypersensitivity	FCGR2A FCGR2B	2.19e-05	2	97	2	GO:0001811
GeneOntologyBiologicalProcess	antibody-dependent cellular cytotoxicity	FCGR2C FCGR2A FCGR2B	2.79e-05	13	97	3	GO:0001788
GeneOntologyBiologicalProcess	type IIa hypersensitivity	FCGR2C FCGR2A FCGR2B	4.40e-05	15	97	3	GO:0001794
GeneOntologyBiologicalProcess	type II hypersensitivity	FCGR2C FCGR2A FCGR2B	4.40e-05	15	97	3	GO:0002445
GeneOntologyBiologicalProcess	activation of NF-kappaB-inducing kinase activity	TLR6 TLR1 TLR3	6.54e-05	17	97	3	GO:0007250
GeneOntologyBiologicalProcess	detection of bacterial lipopeptide	TLR6 TLR1	6.55e-05	3	97	2	GO:0070340
GeneOntologyBiologicalProcess	detection of bacterial lipoprotein	TLR6 TLR1	1.31e-04	4	97	2	GO:0042494
GeneOntologyBiologicalProcess	negative regulation of hypersensitivity	FCGR2A FCGR2B	1.31e-04	4	97	2	GO:0002884
GeneOntologyBiologicalProcess	desmosome assembly	PKP3 PKP2	1.31e-04	4	97	2	GO:0002159
GeneOntologyBiologicalProcess	hypersensitivity	FCGR2C FCGR2A FCGR2B	2.15e-04	25	97	3	GO:0002524
GeneOntologyBiologicalProcess	regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	FCGR2A FCGR2B	2.17e-04	5	97	2	GO:1903381
GeneOntologyBiologicalProcess	negative regulation of neutrophil apoptotic process	FCGR2A FCGR2B	2.17e-04	5	97	2	GO:0033030
GeneOntologyCellularComponent	keratohyalin granule	FLG HRNR FLG2	9.32e-07	5	96	3	GO:0036457
GeneOntologyCellularComponent	cornified envelope	FLG HRNR FLG2 PKP3 PKP2	1.64e-05	69	96	5	GO:0001533
Domain	Filaggrin	FLG FLG2	2.61e-05	2	96	2	IPR003303
Domain	PDEase_N	PDE1C PDE1B	7.82e-05	3	96	2	IPR013706
Domain	PDEase_I_N	PDE1C PDE1B	7.82e-05	3	96	2	PF08499
Domain	PDEase	PDE1C PDE1B PDE11A	1.20e-04	19	96	3	IPR023088
Domain	PDEase_I	PDE1C PDE1B PDE11A	1.64e-04	21	96	3	PF00233
Domain	PDEASE_I	PDE1C PDE1B PDE11A	1.64e-04	21	96	3	PS00126
Domain	PDEase_CS	PDE1C PDE1B PDE11A	1.64e-04	21	96	3	IPR023174
Domain	TIR	TLR6 TLR1 TLR3	1.64e-04	21	96	3	SM00255
Domain	TIR	TLR6 TLR1 TLR3	1.89e-04	22	96	3	PF01582
Domain	-	PDE1C PDE1B PDE11A	1.89e-04	22	96	3	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE1C PDE1B PDE11A	2.16e-04	23	96	3	IPR002073
Domain	-	TLR6 TLR1 TLR3	2.16e-04	23	96	3	3.40.50.10140
Domain	HDc	PDE1C PDE1B PDE11A	2.46e-04	24	96	3	SM00471
Domain	HD/PDEase_dom	PDE1C PDE1B PDE11A	2.46e-04	24	96	3	IPR003607
Domain	TIR	TLR6 TLR1 TLR3	2.46e-04	24	96	3	PS50104
Domain	Toll-like_receptor	TLR6 TLR1	2.59e-04	5	96	2	IPR017241
Domain	TIR_dom	TLR6 TLR1 TLR3	2.79e-04	25	96	3	IPR000157
Domain	S100_CABP	FLG HRNR FLG2	3.52e-04	27	96	3	PS00303
Domain	S_100	FLG HRNR FLG2	3.52e-04	27	96	3	PF01023
Domain	HELP	EML2 EML1	3.87e-04	6	96	2	PF03451
Domain	HELP	EML2 EML1	3.87e-04	6	96	2	IPR005108
Domain	S100_Ca-bd_sub	FLG HRNR FLG2	3.93e-04	28	96	3	IPR013787
Domain	S100/CaBP-9k_CS	FLG HRNR FLG2	3.93e-04	28	96	3	IPR001751
Domain	S_100	FLG HRNR FLG2	3.93e-04	28	96	3	SM01394
Domain	Alkaline_phosphatase_core	ARSA ARSF ALPI	5.33e-04	31	96	3	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ARSA ARSF ALPI	5.33e-04	31	96	3	IPR017849
Domain	-	ARSA ARSF ALPI	5.33e-04	31	96	3	3.40.720.10
Domain	PrprotnconvertsP	PCSK6 PCSK7	5.40e-04	7	96	2	IPR002884
Domain	GPCR_kinase	GRK2 GRK3	5.40e-04	7	96	2	IPR000239
Domain	P_proprotein	PCSK6 PCSK7	5.40e-04	7	96	2	PF01483
Domain	Plakophilin/d_Catenin	PKP3 PKP2	5.40e-04	7	96	2	IPR028435
Domain	S8_pro-domain	PCSK6 PCSK7	5.40e-04	7	96	2	IPR032815
Domain	-	PCSK6 PCSK7	5.40e-04	7	96	2	3.30.70.850
Domain	S8_pro-domain	PCSK6 PCSK7	5.40e-04	7	96	2	PF16470
Domain	LRRCT	TLR6 TLR1 TLR3	5.86e-04	32	96	3	PF01463
Domain	Peptidase_S8_His-AS	PCSK6 PCSK7	9.19e-04	9	96	2	IPR022398
Domain	Peptidase_S8_Ser-AS	PCSK6 PCSK7	9.19e-04	9	96	2	IPR023828
Domain	Peptidase_S8_subtilisin-rel	PCSK6 PCSK7	1.15e-03	10	96	2	IPR015500
Domain	SUBTILASE_ASP	PCSK6 PCSK7	1.15e-03	10	96	2	PS00136
Domain	SUBTILASE_HIS	PCSK6 PCSK7	1.15e-03	10	96	2	PS00137
Domain	SUBTILASE_SER	PCSK6 PCSK7	1.15e-03	10	96	2	PS00138
Domain	Cys-rich_flank_reg_C	TLR6 AMIGO1 TLR1 TLR3	1.19e-03	90	96	4	IPR000483
Domain	LRRCT	TLR6 AMIGO1 TLR1 TLR3	1.19e-03	90	96	4	SM00082
Domain	-	PCSK6 PCSK7	1.40e-03	11	96	2	3.40.50.200
Domain	Peptidase_S8/S53_dom	PCSK6 PCSK7	1.40e-03	11	96	2	IPR000209
Domain	Peptidase_S8	PCSK6 PCSK7	1.40e-03	11	96	2	PF00082
Domain	Quinoprot_gluc/sorb_DH	EML2 FBXW5	1.67e-03	12	96	2	IPR011041
Domain	Sulfatase_CS	ARSA ARSF	2.99e-03	16	96	2	IPR024607
Domain	SULFATASE_1	ARSA ARSF	3.38e-03	17	96	2	PS00523
Domain	Propept_inh	PCSK6 PCSK7	3.38e-03	17	96	2	IPR009020
Domain	SULFATASE_2	ARSA ARSF	3.38e-03	17	96	2	PS00149
Domain	Sulfatase	ARSA ARSF	3.79e-03	18	96	2	PF00884
Domain	Sulfatase_N	ARSA ARSF	3.79e-03	18	96	2	IPR000917
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	FLG HRNR FLG2	2.24e-08	3	99	3	23403047
Pubmed	Functional Fcgamma receptor polymorphisms are associated with human allergy.	FCGR2C FCGR2A FCGR2B	2.24e-08	3	99	3	24586589
Pubmed	Nonallelic homologous recombination of the FCGR2/3 locus results in copy number variation and novel chimeric FCGR2 genes with aberrant functional expression.	FCGR2C FCGR2A FCGR2B	2.24e-08	3	99	3	26133275
Pubmed	SNPs of Fc-gamma receptor genes and chronic periodontitis.	FCGR2C FCGR2A FCGR2B	2.23e-07	5	99	3	20439936
Pubmed	Copy number, linkage disequilibrium and disease association in the FCGR locus.	FCGR2C FCGR2A FCGR2B	2.23e-07	5	99	3	20508037
Pubmed	Proprotein convertase expression and localization in epidermis: evidence for multiple roles and substrates.	FLG PCSK6 PCSK7	2.23e-07	5	99	3	11380615
Pubmed	Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B.	FCGR2C FCGR2A FCGR2B	2.23e-07	5	99	3	19309690
Pubmed	Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.	TLR6 TLR1 TLR3	4.45e-07	6	99	3	10426995
Pubmed	Isolated Toll-like receptor transmembrane domains are capable of oligomerization.	TLR6 TLR1 TLR3	7.77e-07	7	99	3	23155421
Pubmed	Polymorphisms of toll like receptors in the genetics of severe RSV associated diseases.	TLR6 TLR1 TLR3	7.77e-07	7	99	3	18776592
Pubmed	Characterization and chromosomal distribution of endogenous mouse mammary tumor viruses of European mouse strains STS/A and GR/A.	TCN2 FCGR2A FCGR2B	7.77e-07	7	99	3	2997987
Pubmed	Identification of genetic loci associated with Helicobacter pylori serologic status.	TLR6 FCGR2A TLR1	7.77e-07	7	99	3	23652523
Pubmed	Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.	TLR6 TLR1 TLR3	1.24e-06	8	99	3	20100933
Pubmed	Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.	TLR6 TLR1 TLR3	1.24e-06	8	99	3	11561001
Pubmed	Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.	TLR6 TLR1 TLR3	1.86e-06	9	99	3	24091496
Pubmed	[Expression of toll-like receptors in human epidermal keratinocytes].	TLR6 TLR1 TLR3	2.65e-06	10	99	3	18686608
Pubmed	Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.	TLR6 TLR1 TLR3	2.65e-06	10	99	3	20227302
Pubmed	Toll-like receptors.	TLR6 TLR1 TLR3	2.65e-06	10	99	3	11782555
Pubmed	A family of human receptors structurally related to Drosophila Toll.	TLR6 TLR1 TLR3	2.65e-06	10	99	3	9435236
Pubmed	Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.	TLR6 TLR1 TLR3	3.63e-06	11	99	3	17572686
Pubmed	Toll-like receptors.	TLR6 TLR1 TLR3	3.63e-06	11	99	3	18394314
Pubmed	Pathogen recognition in the innate immune response.	TLR6 TLR1 TLR3	4.83e-06	12	99	3	19382893
Pubmed	Murine cerebral malaria development is independent of toll-like receptor signaling.	TLR6 TLR1 TLR3	4.83e-06	12	99	3	17456769
Pubmed	Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE.	TLR6 TLR1 TLR3	4.83e-06	12	99	3	19254290
Pubmed	Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases.	PDE1C PDE1B PDE11A	6.27e-06	13	99	3	8557689
Pubmed	YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes.	TLR6 TLR1 TLR3	7.96e-06	14	99	3	34206257
Pubmed	MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals.	TLR6 TLR1 TLR3	7.96e-06	14	99	3	16886064
Pubmed	Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients.	TLR6 TLR1 TLR3	7.96e-06	14	99	3	20595247
Pubmed	The amplified mouse squamous cell carcinoma antigen gene locus contains a serpin (Serpinb3b) that inhibits both papain-like cysteine and trypsin-like serine proteinases.	SERPINB3 SERPINB4	8.02e-06	2	99	2	15203214
Pubmed	Increased Th1 immune response in SERPINB3 transgenic mice during acute liver failure.	SERPINB3 SERPINB4	8.02e-06	2	99	2	23354406
Pubmed	Serpin B4 isoform overexpression is associated with aberrant epithelial proliferation and lung cancer in idiopathic pulmonary fibrosis.	SERPINB3 SERPINB4	8.02e-06	2	99	2	22406480
Pubmed	Human FcγRII cytoplasmic domains differentially influence antibody-mediated dengue virus infection.	FCGR2A FCGR2B	8.02e-06	2	99	2	23616574
Pubmed	FcgammaRIIa (CD32) polymorphism and anti-malarial IgG subclass pattern among Fulani and sympatric ethnic groups living in eastern Sudan.	FCGR2A FCGR2B	8.02e-06	2	99	2	19284648
Pubmed	FcγRIIb on myeloid cells rather than on B cells protects from collagen-induced arthritis.	FCGR2A FCGR2B	8.02e-06	2	99	2	24842758
Pubmed	Uptake of human papillomavirus virus-like particles by dendritic cells is mediated by Fcgamma receptors and contributes to acquisition of T cell immunity.	FCGR2A FCGR2B	8.02e-06	2	99	2	17548594
Pubmed	Follicular dendritic cell (FDC)-FcgammaRIIB engagement via immune complexes induces the activated FDC phenotype associated with secondary follicle development.	FCGR2A FCGR2B	8.02e-06	2	99	2	17013985
Pubmed	Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6.	TLR6 TLR1	8.02e-06	2	99	2	22315281
Pubmed	Intraperitoneal Immunization with Cry1Ac Protoxin from Bacillus thuringiensis Provokes Upregulation of Fc-Gamma-II/and Fc-Gamma-III Receptors Associated with IgG in the Intestinal Epithelium of Mice.	FCGR2A FCGR2B	8.02e-06	2	99	2	25904149
Pubmed	Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc gammaRIIB-deficient mice.	FCGR2A FCGR2B	8.02e-06	2	99	2	21078890
Pubmed	FcγRIIB is a T cell checkpoint in antitumor immunity.	FCGR2A FCGR2B	8.02e-06	2	99	2	33616086
Pubmed	Etanercept prevents TNF-α mediated mandibular bone loss in FcγRIIb-/- lupus model.	FCGR2A FCGR2B	8.02e-06	2	99	2	33861790
Pubmed	Notch1 confers thymocytes a resistance to GC-induced apoptosis through Deltex1 by blocking the recruitment of p300 to the SRG3 promoter.	DTX1 RBPJ	8.02e-06	2	99	2	16341126
Pubmed	TEAD3 inhibits the proliferation and metastasis of prostate cancer via suppressing ADRBK2.	TEAD3 GRK3	8.02e-06	2	99	2	36907139
Pubmed	Recurrent SERPINB3 and SERPINB4 mutations in patients who respond to anti-CTLA4 immunotherapy.	SERPINB3 SERPINB4	8.02e-06	2	99	2	27668655
Pubmed	Cloning of GRK2 cDNA from S49 murine lymphoma cells.	GRK2 GRK3	8.02e-06	2	99	2	8638670
Pubmed	Lupus-like Disease in FcγRIIB-/- Mice Induces Osteopenia.	FCGR2A FCGR2B	8.02e-06	2	99	2	31758072
Pubmed	Role of TLR1 and TLR6 in the host defense against disseminated candidiasis.	TLR6 TLR1	8.02e-06	2	99	2	18036178
Pubmed	FcgammaRIIb inhibits allergic lung inflammation in a murine model of allergic asthma.	FCGR2A FCGR2B	8.02e-06	2	99	2	20179765
Pubmed	Respiratory syncytial virus persistence in macrophages upregulates Fcgamma receptors expression.	FCGR2A FCGR2B	8.02e-06	2	99	2	24509813
Pubmed	Antigen-Specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells.	FCGR2A FCGR2B	8.02e-06	2	99	2	21477339
Pubmed	Therapeutic inhibition of FcγRIIb signaling targets leukemic stem cells in chronic myeloid leukemia.	FCGR2A FCGR2B	8.02e-06	2	99	2	32684632
Pubmed	Opposite regulation of type II and III receptors for immunoglobulin G in mouse glomerular mesangial cells and in the induction of anti-glomerular basement membrane (GBM) nephritis.	FCGR2A FCGR2B	8.02e-06	2	99	2	11983693
Pubmed	Acute Kidney Injury Induced Lupus Exacerbation Through the Enhanced Neutrophil Extracellular Traps (and Apoptosis) in Fcgr2b Deficient Lupus Mice With Renal Ischemia Reperfusion Injury.	FCGR2A FCGR2B	8.02e-06	2	99	2	34248948
Pubmed	Negative regulation of c-kit-mediated cell proliferation by Fc gamma RIIB.	FCGR2A FCGR2B	8.02e-06	2	99	2	10201978
Pubmed	Antigen-induced oligomerization of the B cell receptor is an early target of Fc gamma RIIB inhibition.	FCGR2A FCGR2B	8.02e-06	2	99	2	20083655
Pubmed	Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.	FCGR2C FCGR2B	8.02e-06	2	99	2	2531080
Pubmed	Genomic organization of mouse Fc gamma receptor genes.	FCGR2A FCGR2B	8.02e-06	2	99	2	2138787
Pubmed	Fc receptors: rubor redux.	FCGR2A FCGR2B	8.02e-06	2	99	2	8069908
Pubmed	Atopic Dermatitis Susceptibility Variants in Filaggrin Hitchhike Hornerin Selective Sweep.	FLG HRNR	8.02e-06	2	99	2	27678121
Pubmed	Genetic control of T-cell proliferative response in mice linked to chromosomes 11 and 15.	FCGR2A FCGR2B	8.02e-06	2	99	2	8824160
Pubmed	Regulation of allograft survival by inhibitory FcγRIIb signaling.	FCGR2A FCGR2B	8.02e-06	2	99	2	23150718
Pubmed	Expression of Fc gamma RIII defines distinct subpopulations of fetal liver B cell and myeloid precursors.	FCGR2A FCGR2B	8.02e-06	2	99	2	7664793
Pubmed	The association of genetic variants in toll-like receptor 2 subfamily with allergy and asthma after hospitalization for bronchiolitis in infancy.	TLR6 TLR1	8.02e-06	2	99	2	24445834
Pubmed	FcγRIIIA Negatively Impacts Humoral Immune Responses but Not Overall Lung Inflammation in an Ovalbumin-Induced Allergic Asthma Mouse Model.	FCGR2A FCGR2B	8.02e-06	2	99	2	29597194
Pubmed	FcγRIIB modulates splenic germinal center response against immune subversion during acute influenza A virus infection.	FCGR2A FCGR2B	8.02e-06	2	99	2	38087748
Pubmed	Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus.	FCGR2A FCGR2B	8.02e-06	2	99	2	21357255
Pubmed	Selective regulation of autoreactive B cells by FcgammaRIIB.	FCGR2A FCGR2B	8.02e-06	2	99	2	19327966
Pubmed	Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses.	FCGR2A FCGR2B	8.02e-06	2	99	2	12370366
Pubmed	Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.	GRK2 GRK3	8.02e-06	2	99	2	33060647
Pubmed	Association of FcγRIIB and FcγRIIA R131H gene polymorphisms with renal involvement in Egyptian systemic lupus erythematosus patients.	FCGR2A FCGR2B	8.02e-06	2	99	2	24366619
Pubmed	Deletion or inhibition of Fc gamma receptor 2B (CD32) prevents FVIII-specific activation of memory B cells in vitro.	FCGR2A FCGR2B	8.02e-06	2	99	2	26245154
Pubmed	[DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF MICROBIAL COMPONENT SENSOR GENES TLR1 AND TLR6 IN MAJOR POPULATIONS OF SOUTH URALS].	TLR6 TLR1	8.02e-06	2	99	2	26470427
Pubmed	FcgammaRIIa and FcgammaRIIIb polymorphisms were not associated with meningococcal disease in Western Norway.	FCGR2A FCGR2B	8.02e-06	2	99	2	12729187
Pubmed	Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors.	FCGR2A FCGR2B	8.02e-06	2	99	2	2946078
Pubmed	Human antibodies induce arthritis in mice deficient in the low-affinity inhibitory IgG receptor Fc gamma RIIB.	FCGR2A FCGR2B	8.02e-06	2	99	2	16476768
Pubmed	Differences in endocytosis mediated by FcγRIIA and FcγRIIB2.	FCGR2A FCGR2B	8.02e-06	2	99	2	21945020
Pubmed	Reversal of immune thrombocytopenia in mice by cross-linking human immunoglobulin G with a high-affinity monoclonal antibody.	FCGR2A FCGR2B	8.02e-06	2	99	2	16925577
Pubmed	FcgRIII Deficiency and FcgRIIb Defeciency Promote Renal Injury in Diabetic Mice.	FCGR2A FCGR2B	8.02e-06	2	99	2	31534958
Pubmed	FcγRIIb on liver sinusoidal endothelium clears small immune complexes.	FCGR2A FCGR2B	8.02e-06	2	99	2	23053513
Pubmed	A complementary DNA clone for a macrophage-lymphocyte Fc receptor.	FCGR2A FCGR2B	8.02e-06	2	99	2	3024012
Pubmed	G protein--coupled receptor kinases.	GRK2 GRK3	8.02e-06	2	99	2	8035170
Pubmed	Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants.	TLR6 TLR1	8.02e-06	2	99	2	21852947
Pubmed	Human rhinovirus type 2-antibody complexes enter and infect cells via Fc-gamma receptor IIB1.	FCGR2A FCGR2B	8.02e-06	2	99	2	14990693
Pubmed	Fcgamma receptor IIB-deficient mice develop Goodpasture's syndrome upon immunization with type IV collagen: a novel murine model for autoimmune glomerular basement membrane disease.	FCGR2A FCGR2B	8.02e-06	2	99	2	10704470
Pubmed	Endothelial Fcγ Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice.	FCGR2A FCGR2B	8.02e-06	2	99	2	27207525
Pubmed	Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: a case control study of north Indian population from Agra (India).	TLR6 TLR1	8.02e-06	2	99	2	24984237
Pubmed	Biochemical characterization of murine lymphoid alloantigen Ly-m20.2, a cell surface marker controlled by a gene linked to the Mls locus.	FCGR2A FCGR2B	8.02e-06	2	99	2	3161943
Pubmed	Lipopolysaccharide Impedes Bone Repair in FcγRIIB-Deficient Mice.	FCGR2A FCGR2B	8.02e-06	2	99	2	38069267
Pubmed	Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcgammaRII.	FCGR2A FCGR2B	8.02e-06	2	99	2	10704418
Pubmed	Plasmodium curtails autoimmune nephritis via lasting bone marrow alterations, independent of hemozoin accumulation.	FCGR2A FCGR2B	8.02e-06	2	99	2	37539049
Pubmed	Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies.	FCGR2A FCGR2B	8.02e-06	2	99	2	23897982
Pubmed	CD32B, the human inhibitory Fc-gamma receptor IIB, as a target for monoclonal antibody therapy of B-cell lymphoma.	FCGR2A FCGR2B	8.02e-06	2	99	2	16757681
Pubmed	Identification of multiple isoforms of the low-affinity human IgG Fc receptor.	FCGR2A FCGR2B	8.02e-06	2	99	2	2526077
Pubmed	Polymorphisms in IgG Fc receptor IIB regulatory regions associated with autoimmune susceptibility.	FCGR2A FCGR2B	8.02e-06	2	99	2	10866109
Pubmed	FcγRIIb attenuates TLR4‑mediated NF‑κB signaling in B cells.	FCGR2A FCGR2B	8.02e-06	2	99	2	28849025
Pubmed	Fc receptor beta chain deficiency exacerbates murine arthritis in the anti-type II collagen antibody-induced experimental model.	FCGR2A FCGR2B	8.02e-06	2	99	2	23053716
Pubmed	FcgammaRIIB in IgG-mediated suppression of antibody responses: different impact in vivo and in vitro.	FCGR2A FCGR2B	8.02e-06	2	99	2	11698426
Pubmed	Expression of the autoimmune Fcgr2b NZW allele fails to be upregulated in germinal center B cells and is associated with increased IgG production.	FCGR2A FCGR2B	8.02e-06	2	99	2	17713556
Pubmed	Fc gamma RIIB regulates nasal and oral tolerance: a role for dendritic cells.	FCGR2A FCGR2B	8.02e-06	2	99	2	15843524
Pubmed	Lupus nephritis progression in FcγRIIB-/-yaa mice is associated with early development of glomerular electron dense deposits and loss of renal DNase I in severe disease.	FCGR2A FCGR2B	8.02e-06	2	99	2	29190833
Interaction	OR2A4 interactions	FLG EML2 SQOR ARSF SERPINB3 SERPINB4 PKP3 ENDOU	3.91e-07	145	94	8	int:OR2A4
Interaction	STX17 interactions	FLG EML2 CP FLG2 SQOR SERPINB3 SERPINB4 PKP3 ENDOU	4.12e-06	265	94	9	int:STX17
Interaction	HTN3 interactions	FLG DNAJB11 HRNR PLCH1	1.11e-05	30	94	4	int:HTN3
Interaction	RIPPLY3 interactions	FLG MAN2C1 SQOR SERPINB3 SERPINB4 ENDOU	1.41e-05	112	94	6	int:RIPPLY3
Interaction	CDPF1 interactions	SQOR ZIC1 HOXA1 CATSPER1	2.61e-05	37	94	4	int:CDPF1
Interaction	SH2D3A interactions	FLG FLG2 ARSA SERPINB3 SERPINB4	2.64e-05	75	94	5	int:SH2D3A
Interaction	GPR18 interactions	FLG SERPINB3 SERPINB4	3.45e-05	14	94	3	int:GPR18
Interaction	CFAP68 interactions	MAGT1 ZIC1 HOXA1 CATSPER1	4.76e-05	43	94	4	int:CFAP68
Interaction	PRSS16 interactions	FLG FLG2 SERPINB3 SERPINB4	5.22e-05	44	94	4	int:PRSS16
Interaction	FCGR2C interactions	FCGR2C FCGR2A	6.44e-05	3	94	2	int:FCGR2C
Cytoband	18q21.3	SERPINB3 SERPINB4	2.50e-04	11	99	2	18q21.3
GeneFamily	EF-hand domain containing\|S100 fused type protein family	FLG HRNR FLG2	2.18e-06	7	73	3	1350
GeneFamily	CD molecules\|Toll like receptors	TLR6 TLR1 TLR3	7.43e-06	10	73	3	948
GeneFamily	Phosphodiesterases	PDE1C PDE1B PDE11A	1.20e-04	24	73	3	681
GeneFamily	Proprotein convertase subtilisin/kexin family	PCSK6 PCSK7	5.68e-04	9	73	2	973
GeneFamily	Cadherin related	CLSTN3 FAT2	2.10e-03	17	73	2	24
GeneFamily	Sulfatases	ARSA ARSF	2.36e-03	18	73	2	410
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	TLR6 FCGR2C FCGR2A FCGR2B TLR1 TLR3	5.14e-03	394	73	6	471
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	IKZF2 ZNF148 ZNF214 ZNF112 ZIC1 ZNF808 ZNF81 ZNF443	8.23e-03	718	73	8	28
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	DOCK9 GRK2 GRK3 PLEKHM3	9.66e-03	206	73	4	682
GeneFamily	Serpin peptidase inhibitors	SERPINB3 SERPINB4	9.77e-03	37	73	2	739
GeneFamily	EF-hand domain containing	FLG HRNR FLG2 PLCH1	1.19e-02	219	73	4	863
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PKP3 PKP2	1.30e-02	43	73	2	409
Coexpression	IL21_UP.V1_UP	CLSTN3 TEAD3 TLR6 FAT2 MYOZ1 TLR3 PCSK7 UGT8 PYGM	3.76e-08	186	99	9	M2827
Coexpression	FULLER_PBMC_F_TULARENSIS_VACCINE_LVS_AGE_22_54YO_18HR_UP	TLR6 ADAMDEC1 FCGR2A FCGR2B TLR1 TLR3	7.73e-08	57	99	6	M40884
Coexpression	FULLER_PBMC_F_TULARENSIS_VACCINE_LVS_AGE_22_54YO_48HR_UP	TLR6 ADAMDEC1 FCGR2A FCGR2B TLR1 TLR3	1.06e-07	60	99	6	M40883
Coexpression	FULLER_PBMC_F_TULARENSIS_VACCINE_LVS_AGE_22_54YO_336HR_UP	TLR6 ADAMDEC1 FCGR2A TLR1 TLR3	8.42e-07	46	99	5	M40885
Coexpression	FULLER_PBMC_F_TULARENSIS_VACCINE_LVS_AGE_22_54YO_192HR_UP	TLR6 ADAMDEC1 TLR1 TLR3	2.53e-05	45	99	4	M40886
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder epithelial cells_emap-30875_k-means-cluster#2_top-relative-expression-ranked_500	IKZF2 HOXA1 PKP3 UGT8 PLCH1 LNX1 CCSER1	4.27e-06	148	94	7	gudmap_developingLowerUrinaryTract_e13.5_bladder epithelial cells_500_k2
CoexpressionAtlas	Myeloid Cells, DC.103-11b+.SI, CD45+ MHCII+ CD11c-hi CD11b+ CD103- F4/80+, Small Intestine, avg-7	PDE1B TRPM2 CP TLR6 SKIL GRK3 ADAMDEC1 FCGR2A FCGR2B TLR1	7.29e-06	381	94	10	GSM854262_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_emap-30875_top-relative-expression-ranked_1000	SOX6 IKZF2 SKIL INIP HOXA1 NFE2L3 GRK3 ADAMDEC1 PKP3 UGT8 PLCH1 LNX1 PCDH10 CCSER1	1.10e-05	800	94	14	gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_1000
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_top-relative-expression-ranked_1000	SOX6 IKZF2 PGM2L1 HIPK3 NFE2L3 FCGR2B TLR3 ENAH USP7 KANK4 PKP2 UGT8 PLCH1	5.10e-05	801	94	13	gudmap_developingKidney_e15.5_ureter tip_1000_flank cortic collct
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 DTX1 NAALADL2 RBM20 MALRD1 UGT8 LNX1 CCSER1	1.17e-08	192	99	8	562df5e87038c500dd3a003fe5374cb31946b145
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 DTX1 NAALADL2 MALRD1 UGT8 LNX1 CCSER1	1.59e-07	180	99	7	9e09b3dfe344b5d50520711513d389865d73a861
ToppCell	cellseq2-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TRPM2 TLR6 CATSPER1 GRK3 FCGR2A FCGR2B TLR1	1.78e-07	183	99	7	9840706f972387241bf1d4ba8af25efc3214a91b
ToppCell	cellseq2-Immune-Immune_Myeloid-Myeloid_Dendritic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TRPM2 TLR6 CATSPER1 GRK3 FCGR2A FCGR2B TLR1	1.78e-07	183	99	7	409cb52cf4c967e52bf75a6680bcbe87f638c75d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 NAALADL2 RBM20 MALRD1 UGT8 LNX1 CCSER1	1.85e-07	184	99	7	e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 NAALADL2 RBM20 MALRD1 UGT8 LNX1 CCSER1	2.14e-07	188	99	7	2ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	SOX6 CLDN22 NAALADL2 UGT8 IMMP2L NLK CCSER1	2.22e-07	189	99	7	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 DTX1 RBM20 MALRD1 UGT8 LNX1 CCSER1	2.30e-07	190	99	7	3dcadabbefe0128a5f30ab51234f049ab4d870c6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SOX6 CA12 NAALADL2 UGT8 IMMP2L HYDIN CCSER1	2.65e-07	194	99	7	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SOX6 CA12 NAALADL2 UGT8 IMMP2L HYDIN CCSER1	2.84e-07	196	99	7	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	Tracheal\|World / Cell types per location group and 10X technology with lineage, and cell group designations	CP NAALADL2 SERPINB3 SERPINB4 PKP2 LNX1 CCSER1	3.25e-07	200	99	7	682960e28542a3d6c119047cd0131941932cfdea
ToppCell	TCGA-Stomach-Solid_Tissue_Normal-Stomach_normal_tissue-Stomach_normal_tissue-4\|TCGA-Stomach / Sample_Type by Project: Shred V9	FLG MUC21 FAT2 ARSF SERPINB3 ENDOU	1.41e-06	157	99	6	2553ebf3e48de5bd184e77bd61114faa5a1d95ed
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-4\|TCGA-Stomach / Sample_Type by Project: Shred V9	MUC21 IKZF2 FAT2 ARSF SERPINB3 ENDOU	1.75e-06	163	99	6	6a12b802cb181f979ebc72674f3626fb855024e3
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IKZF2 SERPINB3 SERPINB4 PKP3 IMMP2L ZNF443	1.94e-06	166	99	6	9fd9de82f98b9acdaa59ac98fb9664161514aec0
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9\|TCGA-Bladder / Sample_Type by Project: Shred V9	CP MAGT1 SKIL FAT2 SERPINB3 SERPINB4	2.31e-06	171	99	6	adbcfa4bf6bc1c604535a24435924cdb091e2dd7
ToppCell	NS-critical-d_16-33-Epithelial-Basal\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CA12 XG CLDN22 FAT2 SERPINB3 SERPINB4	2.47e-06	173	99	6	3d3afc9ab234eaabf5b9bff455406231cd54ded6
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC2-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NFE2L3 SLC41A2 GRK3 FCGR2B PKP2 CCSER1	2.73e-06	176	99	6	a31d7532f8c055d4e62bbaa78d819f2495bfee00
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 DTX1 MALRD1 UGT8 LNX1 CCSER1	3.11e-06	180	99	6	eee71184ebed2694d3e60f579a44b3cf7dd2cd35
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 DTX1 MALRD1 UGT8 LNX1 CCSER1	3.11e-06	180	99	6	a17dbe03597b81e7a1fe2bf2d23e59e55c615a2a
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CP NFE2L3 SLC41A2 KANK4 PLCH1 LNX1	3.21e-06	181	99	6	0513b9e6673ff7bf8e72ba123ca3794b65d10170
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TPSD1 GRK3 FCGR2A FCGR2B TLR1 RBPJ	3.42e-06	183	99	6	a97f052950429245c3231464271e1ba539863bba
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 NAALADL2 MALRD1 UGT8 LNX1 CCSER1	3.42e-06	183	99	6	31ab55d5f3639f5964541d5eae23044dbda3356e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 CLDN22 NAALADL2 UGT8 LNX1 CCSER1	3.52e-06	184	99	6	d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 CLDN22 NAALADL2 UGT8 LNX1 CCSER1	3.52e-06	184	99	6	8fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 NAALADL2 MALRD1 UGT8 LNX1 CCSER1	3.64e-06	185	99	6	898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCell	NS-critical-LOC-Epithelial-Basal\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CA12 CP FAT2 SERPINB3 SERPINB4 PKP3	3.75e-06	186	99	6	c28f62524637c7eb9c43c9ec38fb12dfec6f5566
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 DTX1 MALRD1 UGT8 LNX1 CCSER1	3.87e-06	187	99	6	85e58a312fc325e4063a2d250666b99b8f99beb6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 RBM20 MALRD1 UGT8 LNX1 CCSER1	3.87e-06	187	99	6	7ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CP SLC41A2 KANK4 PLCH1 LNX1 IMMP2L	3.99e-06	188	99	6	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 NAALADL2 MALRD1 UGT8 LNX1 CCSER1	3.99e-06	188	99	6	3cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 NAALADL2 MALRD1 UGT8 LNX1 CCSER1	4.11e-06	189	99	6	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	CP FAT2 SERPINB3 SERPINB4 LNX1 CCSER1	4.11e-06	189	99	6	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	COVID-19-Heart-Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TRPM2 GRK3 FCGR2A FCGR2B TLR1 RBPJ	4.11e-06	189	99	6	2586f4088721c5debec86c2b211b739fd33713eb
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CA12 MUC21 IKZF2 CP PGM2L1 SERPINB3	4.24e-06	190	99	6	6ea9fa08bd97bedcb21d3654467e7f8dd74c8fd0
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 NAALADL2 MALRD1 UGT8 LNX1 CCSER1	4.24e-06	190	99	6	cc17ab84a9328124f146951c06be3eff9650d9fd
ToppCell	Adult-Immune-monocyte-D175\|Adult / Lineage, Cell type, age group and donor	TRPM2 GRK2 FCGR2A FCGR2B TLR1 RBPJ	4.37e-06	191	99	6	cbebb4d9550fdcd606cb3685ac9546c6b73fd422
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CA12 CP PGM2L1 NFE2L3 SERPINB3 SERPINB4	4.64e-06	193	99	6	463274f394757fb2570ae885d58e1f9fa7e60c4a
ToppCell	RV-09._Endothelium_I\|World / Chamber and Cluster_Paper	ANO2 DOCK9 FRYL MAP3K6 EML1 LNX1	4.64e-06	193	99	6	e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCell	COVID-19-Heart-Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	TRPM2 GRK3 FCGR2A FCGR2B TLR1 RBPJ	4.78e-06	194	99	6	f09675cd472200363c458952f00d2e41990800ee
ToppCell	RV-09._Endothelium_I\|RV / Chamber and Cluster_Paper	ANO2 DOCK9 FRYL MAP3K6 EML1 LNX1	4.78e-06	194	99	6	7b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TLR6 ADAMDEC1 FCGR2A FCGR2B TLR1 RBPJ	4.78e-06	194	99	6	48c37251518f96524807b5bd1bbc2820637666ad
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TLR6 ADAMDEC1 FCGR2A FCGR2B TLR1 RBPJ	4.78e-06	194	99	6	7b6a34d1f8922b71dcc931421666c1822cec8345
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM2 GRK3 FCGR2A FCGR2B TLR1 RBPJ	4.78e-06	194	99	6	1dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TLR6 ADAMDEC1 FCGR2A FCGR2B TLR1 RBPJ	4.78e-06	194	99	6	435406ebe626c702f7d5a99a3d68ee85aa09be95
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SOX6 CA12 NAALADL2 UGT8 IMMP2L CCSER1	4.92e-06	195	99	6	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	LV-09._Endothelium_I\|World / Chamber and Cluster_Paper	ANO2 DOCK9 FRYL MAP3K6 EML1 LNX1	4.92e-06	195	99	6	19e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM2 GRK3 FCGR2A FCGR2B TLR1 RBPJ	4.92e-06	195	99	6	34a9462f4e843f3065cc58c17ad71c1b5b836ae1
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDE1C TRPM2 AMIGO1 MEX3B NXPH2 PDE11A	5.07e-06	196	99	6	ef650ff106a76c1e926e13c7f002fbc452cc48ae
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SOX6 CA12 NAALADL2 UGT8 IMMP2L CCSER1	5.07e-06	196	99	6	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM2 GRK3 FCGR2A FCGR2B TLR1 RBPJ	5.22e-06	197	99	6	6ca6e17b7cc5f7ea8d4b6ca1ff670969bee65a45
ToppCell	LV-09._Endothelium_I\|LV / Chamber and Cluster_Paper	ANO2 DOCK9 FRYL MAP3K6 EML1 LNX1	5.22e-06	197	99	6	f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TCN2 TLR6 ADAMDEC1 FCGR2A FCGR2B TLR1	5.37e-06	198	99	6	243109377d62d20c69e9d1fedc252156e90cda1e
ToppCell	COVID-19-kidney-Macrophages\|kidney / Disease (COVID-19 only), tissue and cell type	TRPM2 GRK3 FCGR2A FCGR2B TLR1 RBPJ	5.37e-06	198	99	6	161324541fe5da5cbb58142ea94fefd39b7dfb04
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CA12 CP FAT2 SERPINB3 SERPINB4 PKP3	5.53e-06	199	99	6	fbd39d34636137d1b877dd8815d58f124990136b
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CA12 CP FAT2 SERPINB3 SERPINB4 PKP3	5.53e-06	199	99	6	6977f939ddbc47d4921f36c0a61a205259fe1284
ToppCell	proximal-3-Epithelial-Proximal_Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CP FAT2 SERPINB3 SERPINB4 PKP3 PKP2	5.69e-06	200	99	6	3a0c84f9a551fc2581ec3693481eada297d83f7b
ToppCell	Parenchyma_Control_(B.)-Immune-TX-MoAM-2\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	TCN2 TRPM2 ADAMDEC1 FCGR2A FCGR2B RBPJ	5.69e-06	200	99	6	670ef1e68be0d2c6ea20ab4dea1d051a3cc89799
ToppCell	proximal-Epithelial-Proximal_Basal-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CP FAT2 SERPINB3 SERPINB4 PKP3 PKP2	5.69e-06	200	99	6	de9aec87c86ad0a1bd5e0737c2aae0ec6f269bca
ToppCell	proximal-Epithelial-Proximal_Basal\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CP FAT2 SERPINB3 SERPINB4 PKP3 PKP2	5.69e-06	200	99	6	ff2afa5c0352c214525129f9ff85afc139fe44d2
ToppCell	TCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue-6\|TCGA-Bladder / Sample_Type by Project: Shred V9	FLG MUC21 FLG2 ARSF ENDOU	9.58e-06	127	99	5	d61b71572eab8a850ee8ce54323fb247525006e5
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 PDE1C PLCH1 NXPH2 CCSER1	2.07e-05	149	99	5	cc911b454fe4e4b489885b9920baa7eb01a027ba
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MBLAC2 IKZF2 PGM2L1 BLM FBXW5	2.07e-05	149	99	5	65778f19599b4955c0a16f0121237656449431fb
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Club\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	CP CLDN22 FLG2 SERPINB3 SERPINB4	2.75e-05	158	99	5	03281e87780e3bacd089903383c016d03c373bf7
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFE2L3 GRK3 PKP3 RBPJ CCSER1	2.75e-05	158	99	5	90ca742739a208d457db087655ba3d1c18a9da57
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFE2L3 GRK3 PKP3 RBPJ CCSER1	2.92e-05	160	99	5	8dae9b0cf90a09acb196223f45a14680102630b2
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Club\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	PDE1C CP CLDN22 FLG2 SERPINB3	3.10e-05	162	99	5	fe546c2272a70bb5f08e6e097b9accdb891eda23
ToppCell	Dendritic_Cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	TLR6 FCGR2A FCGR2B TLR1 RBPJ	3.48e-05	166	99	5	fbeb74b98b58085de323f744b18d4a8f7b22d5d4
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC41A2 GRK3 TLR1 PLEKHM3 CCSER1	3.48e-05	166	99	5	63dc58864268b4e7779e4c45155022556fc634f9
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D122\|Adult / Lineage, Cell type, age group and donor	PDE1B GRK2 ADAMDEC1 TLR1 RBPJ	3.48e-05	166	99	5	be284e2e596390f05305c7bcfc316f87b963fc0b
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-CR\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ZIC1 FAT2 PKP3 HYDIN	3.55e-05	83	99	4	1ab68323518adc7fd0a459b41fad12d60f97eb5c
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-CR-CR_Lhx5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ZIC1 FAT2 PKP3 HYDIN	3.55e-05	83	99	4	75b27d91a4473286f4b40027e96ac5246f5abe5b
ToppCell	facs-Lung-EPCAM-24m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CP AMIGO1 BLM SLC41A2 KCTD3	3.58e-05	167	99	5	961e722442d786ab15d1e490941d2be265a9057a
ToppCell	facs-Lung-EPCAM-24m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CP AMIGO1 BLM SLC41A2 KCTD3	3.58e-05	167	99	5	3760efc35d4e7e9c2da1a20f9795ddea397e2206
ToppCell	Children_(3_yrs)-Immune-enucleated_erythrocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FCGR2B PCSK6 ARFGAP1 PKP2 PYGM	3.68e-05	168	99	5	8f0c4dfad9f6fed9dcc31795abfe77758ceb46a1
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	TRPM2 RBM20 GRK3 RBPJ CCSER1	3.90e-05	170	99	5	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TEAD3 ARSF SERPINB3 SERPINB4 PKP3	4.01e-05	171	99	5	121e63ca281ad765d76c2afb3b4d441329b47f81
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|metastatic_Lymph_Node / Location, Cell class and cell subclass	NPHS1 PDE1B HOXA1 GRK3 TLR1	4.12e-05	172	99	5	f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Proximal_secretory_2\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CP CLDN22 FAT2 SERPINB3 PKP3	4.24e-05	173	99	5	d1e47c87bd4750801f3531f66a56c5dccb4ea64c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NAALADL2 MALRD1 UGT8 LNX1 CCSER1	4.47e-05	175	99	5	e5467dacf81f1f913b1719931cf1a7331434a7e7
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-4\|TCGA-Lung / Sample_Type by Project: Shred V9	MUC21 SLC41A2 FCGR2C CATSPER1 FCGR2B	4.60e-05	176	99	5	0923b01137d6f9956ca815b41102c81e82624065
ToppCell	Fetal_29-31_weeks-Epithelial-lung_goblet_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CP CLDN22 SERPINB3 LNX1 CCSER1	4.72e-05	177	99	5	a4c001a8e44142babf9f24dfe6f7b73a70b11b16
ToppCell	Fetal_29-31_weeks-Epithelial-lung_goblet_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CP CLDN22 SERPINB3 LNX1 CCSER1	4.72e-05	177	99	5	363e07b0f347f3716d530a28ead854b98e27d37c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DTX1 MALRD1 UGT8 LNX1 CCSER1	4.85e-05	178	99	5	4df6218b20c2f076c22346d23260964cc0d73e65
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CP SLC41A2 KANK4 PLCH1 LNX1	4.98e-05	179	99	5	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	Control-Endothelial_cells-Capillary_endothelial_cells\|Control / group, cell type (main and fine annotations)	PDE1C DOCK9 KCTD3 EML1 LNX1	5.12e-05	180	99	5	b043f9ffb9a4cd427a15bebb86a711c7b08866e8
ToppCell	COVID-19-kidney-CD-IC-B\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SOX6 CA12 PDE1C UGT8 NXPH2	5.39e-05	182	99	5	ee6a8c356bbbdae55e4ea858337e079491f9f4aa
ToppCell	droplet-Thymus-nan-18m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CP NFE2L3 GRK3 EML1 HYDIN	5.39e-05	182	99	5	f6717e97e87513384149800c9fd8dea821ab9393
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 NAALADL2 MALRD1 UGT8 CCSER1	5.39e-05	182	99	5	041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCell	droplet-Thymus-nan-18m-Myeloid-professional_antigen_presenting_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CP NFE2L3 GRK3 EML1 HYDIN	5.39e-05	182	99	5	c33b0d532822186a1e8e645500347972468718c0
ToppCell	LA-11._Adipocyte\|World / Chamber and Cluster_Paper	CA12 CLSTN3 HPSE2 GRK3 KANK4	5.53e-05	183	99	5	b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCell	LPS_only-Epithelial_alveolar-AT_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CP SLC41A2 KANK4 PLCH1 LNX1	5.53e-05	183	99	5	e972432dd4d1bd31bb0982f4df3061e5e152658f
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 PDE1C PLCH1 PCDH10 HYDIN	5.68e-05	184	99	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 PDE1C PLCH1 PCDH10 HYDIN	5.68e-05	184	99	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 PDE1C PLCH1 PCDH10 HYDIN	5.68e-05	184	99	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CP PGM2L1 SERPINB3 SERPINB4 CCSER1	5.68e-05	184	99	5	01c19a830348ab0b9c02c1546a439de70ee10f97
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 DTX1 NAALADL2 UGT8 LNX1	5.82e-05	185	99	5	03f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRPM2 FCGR2A FCGR2B TLR1 RBPJ	5.82e-05	185	99	5	8207f9eff113eed429e961748c6b17d672a13b33
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CA12 FAT2 SERPINB3 SERPINB4 PKP3	5.82e-05	185	99	5	e0172e0ab0f1d7151a3c3c63bb7c84d6bda92035
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NPHS1 CLDN22 SERPINB4 PKP2 PYGM	5.82e-05	185	99	5	11fbea1eb1d9a3e4480d0d2b0f7b02e2866b8142
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IKZF2 CP NAALADL2 SLC41A2 IMMP2L	5.98e-05	186	99	5	4e94158db52df41d71e67b02b9895a358eebee0f
Computational	Genes in the cancer module 424.	FCGR2A TLR1 TLR3	9.27e-05	18	54	3	MODULE_424
Drug	MDL 20,610	FCGR2C FCGR2A FCGR2B	7.68e-07	5	98	3	CID000128209
Drug	TAN-1030A	FCGR2C FCGR2A FCGR2B	1.53e-06	6	98	3	CID009576886
Drug	AC1MHTIN	FCGR2C FCGR2A FCGR2B	2.67e-06	7	98	3	CID003011133
Drug	TAN-999	FCGR2C FCGR2A FCGR2B	2.67e-06	7	98	3	CID000130283
Drug	Intravenous Immunoglobulin	FCGR2C FCGR2A FCGR2B	4.26e-06	8	98	3	DB00028
Drug	histamine	HPSE2 TPSD1 FCGR2C GRK2 GRK3 FCGR2A FCGR2B TLR1 TLR3 PLCH1 NLK ALPI	5.18e-06	560	98	12	CID000000774
Drug	AC1NSK5W	FCGR2C FCGR2A FCGR2B	6.37e-06	9	98	3	CID005311182
Drug	Palivizumab	FCGR2C FCGR2A FCGR2B	9.08e-06	10	98	3	DB00110
Drug	Denny-Jaffe reagent	FCGR2C FCGR2A FCGR2B	9.08e-06	10	98	3	CID003035979
Drug	lawsone	MAN2C1 DTX1 SERPINB3 SERPINB4 RBPJ UGT8	1.05e-05	115	98	6	CID000006755
Drug	Bevacizumab	FCGR2C FCGR2A FCGR2B	1.24e-05	11	98	3	DB00112
Drug	Tositumomab	FCGR2C FCGR2A FCGR2B	1.24e-05	11	98	3	DB00081
Drug	Alemtuzumab	FCGR2C FCGR2A FCGR2B	1.24e-05	11	98	3	DB00087
Drug	Efalizumab	FCGR2C FCGR2A FCGR2B	1.24e-05	11	98	3	DB00095
Drug	Alefacept	FCGR2C FCGR2A FCGR2B	1.24e-05	11	98	3	DB00092
Drug	austin	FCGR2C ARSA ARSF FCGR2A FCGR2B	1.29e-05	70	98	5	CID000430632
Drug	2-Aminopurine	TLR6 TLR1 TLR3	1.65e-05	12	98	3	ctd:D015075
Drug	Daclizumab	FCGR2C FCGR2A FCGR2B	1.65e-05	12	98	3	DB00111
Drug	Natalizumab	FCGR2C FCGR2A FCGR2B	1.65e-05	12	98	3	DB00108
Drug	Rituximab	FCGR2C FCGR2A FCGR2B	1.65e-05	12	98	3	DB00073
Drug	Ibritumomab	FCGR2C FCGR2A FCGR2B	1.65e-05	12	98	3	DB00078
Drug	Adalimumab	FCGR2C FCGR2A FCGR2B	1.65e-05	12	98	3	DB00051
Drug	Gemtuzumab ozogamicin	FCGR2C FCGR2A FCGR2B	1.65e-05	12	98	3	DB00056
Drug	Cetuximab	FCGR2C FCGR2A FCGR2B	1.65e-05	12	98	3	DB00002
Drug	Trastuzumab	FCGR2C FCGR2A FCGR2B	2.14e-05	13	98	3	DB00072
Drug	Basiliximab	FCGR2C FCGR2A FCGR2B	2.14e-05	13	98	3	DB00074
Drug	Abciximab	FCGR2C FCGR2A FCGR2B	2.72e-05	14	98	3	DB00054
Drug	Etanercept	FCGR2C FCGR2A FCGR2B	2.72e-05	14	98	3	DB00005
Drug	2',3'-dideoxyadenosine	TCN2 GRK2 GRK3 FCGR2A PYGM	2.80e-05	82	98	5	CID000020039
Drug	S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (2R)-2-[4-(2-methylpropyl)phenyl]propanethioate	TPSD1 FCGR2C FCGR2A FCGR2B	2.89e-05	41	98	4	CID009854504
Drug	Muromonab	FCGR2C FCGR2A FCGR2B	3.39e-05	15	98	3	DB00075
Drug	AC1L9LSE	FCGR2C FCGR2A FCGR2B	4.16e-05	16	98	3	CID000448272
Drug	milrinone	PDE1C PDE1B GRK2 GRK3 PLCH1 PDE11A	4.73e-05	150	98	6	CID000004197
Drug	2cgx	FCGR2C FCGR2A FCGR2B	6.02e-05	18	98	3	CID001548380
Drug	8-azido cyclic AMP	GRK2 GRK3 PYGM	6.02e-05	18	98	3	CID000115296
Drug	delta-(l-alpha-aminoadipoyl)-l-cysteinyl-glycine	TRPM2 GRK2 GRK3 SERPINB3 SERPINB4 TLR1 ENDOU	6.05e-05	229	98	7	CID004369448
Drug	R13-1	FCGR2C FCGR2A FCGR2B	7.13e-05	19	98	3	CID000009666
Drug	dipyridamole	PDE1C PDE1B TCN2 BLM GRK2 GRK3	7.25e-05	162	98	6	CID000003108
Drug	Loestrin	FCGR2C FCGR2A FCGR2B	9.72e-05	21	98	3	CID000062925
Drug	glycerylcysteine	TLR6 TLR1	1.09e-04	4	98	2	CID000152469
Drug	AC1Q5JRE	FCGR2C FCGR2A FCGR2B	1.12e-04	22	98	3	CID000188349
Drug	AC1L1CFC	SERPINB3 SERPINB4 TLR3 NLK	1.15e-04	58	98	4	CID000001874
Drug	resiquimod	TLR6 FCGR2C FCGR2B TLR1 TLR3	1.41e-04	115	98	5	CID000159603
Drug	tyrphostin 23	FCGR2C GRK2 GRK3 FCGR2A FCGR2B	1.47e-04	116	98	5	CID000002052
Drug	PDEs	PDE1C PDE1B GRK2 GRK3 PDE11A	1.47e-04	116	98	5	CID003036959
Drug	NA-1	FCGR2C FCGR2A FCGR2B UGT8	1.49e-04	62	98	4	CID000446091
Drug	Pam(3)CSK(4) peptide	TLR6 TLR1 TLR3	1.66e-04	25	98	3	ctd:C508075
Drug	LY 294002; Down 200; 10uM; PC3; HT_HG-U133A	PDE1C TRPM2 HOXA1 HIPK3 PKP3 UGT8	1.79e-04	191	98	6	4451_DN
Drug	dihydroquinoline 31	SERPINB3 SERPINB4	1.82e-04	5	98	2	CID010561174
Drug	ChAG	SERPINB3 SERPINB4	1.82e-04	5	98	2	CID000126253
Drug	glucose-6-P	MAN2C1 PGM2L1 HPSE2 ARSA GRK2 GRK3 PYGM ALPI	1.85e-04	366	98	8	CID000000208
Drug	Cyclacillin [3485-14-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	CA12 SKIL MAP3K6 HIPK3 GRK2 PCSK6	2.00e-04	195	98	6	4358_DN
Drug	2-propylpentanoic acid; Down 200; 200uM; MCF7; HT_HG-U133A	MAP3K6 ZIC1 GRK2 GRK3 PCSK6 RBPJ	2.06e-04	196	98	6	5574_DN
Drug	Dantrolene sodium salt [14663-23-1]; Up 200; 11.8uM; HL60; HT_HG-U133A	DOCK9 EML2 MAP3K6 PCSK6 ZNF81 PLCH1	2.17e-04	198	98	6	2369_UP
Disease	malaria (implicated_via_orthology)	FCGR2C FCGR2A FCGR2B	2.76e-06	9	96	3	DOID:12365 (implicated_via_orthology)
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR6 TLR1 TLR3	2.20e-05	17	96	3	DOID:8677 (biomarker_via_orthology)
Disease	low affinity immunoglobulin gamma Fc region receptor II-a measurement	FCGR2C FCGR2A FCGR2B	2.20e-05	17	96	3	EFO_0021969
Disease	anti-Helicobacter pylori serum IgG measurement	FCGR2A TLR1	3.14e-05	3	96	2	EFO_0005247
Disease	low affinity immunoglobulin gamma Fc region receptor II-b measurement	FCGR2C FCGR2A FCGR2B	7.29e-05	25	96	3	EFO_0021970
Disease	serum albumin measurement	SOX6 NPHS1 ZNF148 FCGR2C FCGR2A FCGR2B RBPJ LNX1 PDE11A	1.37e-04	592	96	9	EFO_0004535
Disease	SYSTEMIC LUPUS ERYTHEMATOSUS	FCGR2A FCGR2B	1.56e-04	6	96	2	152700
Disease	low affinity immunoglobulin gamma Fc region receptor II-a/b measurement	FCGR2A FCGR2B	2.18e-04	7	96	2	EFO_0008211
Disease	lymphoid leukemia (is_implicated_in)	FCGR2A FCGR2B	2.18e-04	7	96	2	DOID:1037 (is_implicated_in)
Disease	aspergillosis (is_implicated_in)	TLR6 TLR1	2.90e-04	8	96	2	DOID:13564 (is_implicated_in)
Disease	plexin-B2 measurement	FCGR2C FCGR2B	3.72e-04	9	96	2	EFO_0021867
Disease	systemic lupus erythematosus (implicated_via_orthology)	FCGR2C FCGR2A FCGR2B	3.75e-04	43	96	3	DOID:9074 (implicated_via_orthology)
Disease	glycerophospholipid measurement	ANO2 SQOR UGT8	5.52e-04	49	96	3	EFO_0007630
Disease	response to ondansetron, QT interval	TLR3 LNX1	5.65e-04	11	96	2	EFO_0004682, EFO_0020997
Disease	Systemic lupus erythematosus	FCGR2A FCGR2B	5.65e-04	11	96	2	cv:C0024141
Disease	Ashkenazi Jewish disorders	BLM FCGR2A	5.65e-04	11	96	2	cv:CN118946
Disease	diabetic maculopathy	ZIC1 USP7	6.77e-04	12	96	2	EFO_0010133
Disease	vitamin D measurement	SOX6 NPHS1 FLG HRNR PCSK7 ZNF808	8.18e-04	336	96	6	EFO_0004631
Disease	response to beta blocker, mortality	NAALADL2 SLC41A2	9.29e-04	14	96	2	EFO_0004352, EFO_0007766
Disease	autoimmune thrombocytopenic purpura (is_implicated_in)	FCGR2A FCGR2B	1.07e-03	15	96	2	DOID:8924 (is_implicated_in)
Disease	tumor necrosis factor beta measurement	NAALADL2 IMMP2L	1.07e-03	15	96	2	EFO_0008308
Disease	–	FCGR2A FCGR2B	1.22e-03	16	96	2	611162
Disease	Malaria, susceptibility to	FCGR2A FCGR2B	1.22e-03	16	96	2	cv:C1970028
Disease	low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	NFE2L3 FCGR2B KANK4 PCSK7	1.59e-03	153	96	4	EFO_0004611, EFO_0020946
Disease	Contact Dermatitis	FLG SERPINB3 SERPINB4	1.63e-03	71	96	3	C0011616
Disease	Contact hypersensitivity	FLG SERPINB3 SERPINB4	1.63e-03	71	96	3	C0162351
Disease	Autistic Disorder	TCN2 CP HOXA1 IMMP2L PCDH10	1.66e-03	261	96	5	C0004352
Disease	anorectal malformation	TRPM2 PKP3	1.73e-03	19	96	2	MONDO_0019938
Disease	limited scleroderma	FCGR2B TLR1	1.73e-03	19	96	2	EFO_1001017
Disease	Malaria	FCGR2A FCGR2B	1.92e-03	20	96	2	C0024530
Disease	Neutropenia	TCN2 FCGR2B	2.11e-03	21	96	2	C0027947
Disease	otosclerosis	MAN2C1 MEX3B CCSER1	2.37e-03	81	96	3	EFO_0004213
Disease	Headache, type 2 diabetes mellitus	PCSK6 RBPJ	2.53e-03	23	96	2	HP_0002315, MONDO_0005148
Disease	Rheumatoid Arthritis	CP GRK2 FCGR2A RBPJ	2.55e-03	174	96	4	C0003873
Disease	Drug toxicity	TCN2 CP TLR1	2.63e-03	84	96	3	C0013221
Disease	Adverse reaction to drug	TCN2 CP TLR1	2.63e-03	84	96	3	C0041755
Disease	systemic scleroderma	IKZF2 FLG2 FCGR2B	2.72e-03	85	96	3	EFO_0000717
Disease	tobacco smoke exposure measurement	PDE1C AMIGO1	2.76e-03	24	96	2	EFO_0009115
Disease	Albuminuria	NPHS1 CP	2.76e-03	24	96	2	C0001925
Disease	malaria (is_implicated_in)	FCGR2A FCGR2B	2.76e-03	24	96	2	DOID:12365 (is_implicated_in)
Disease	corpus collosum mid-posterior volume measurement	SQOR LNX1	2.99e-03	25	96	2	EFO_0010300

Protein segments in the cluster

Peptide	Gene	Start	Entry
NNTLVYFTSDHGGHL	ARSF	336	P54793
RSHQESKYHFGGHVQ	LINC00158	41	P58513
DHHGNSNVLYGQHRF	BAHCC1	141	Q9P281
FTLHGHHDTLNTAYT	AMIGO1	361	Q86WK6
GGDLHYHLSQHGVFS	GRK3	276	P35626
TTQGDPLSIHHYFHG	CLSTN3	511	Q9BQT9
HHDGSQYGGFHQQSD	CATSPER1	126	Q8NEC5
QYGGFHQQSDSHYHR	CATSPER1	131	Q8NEC5
HSDKHVASHGFSAGY	CDCP2	126	Q5VXM1
QANHSHSGDYHCTGN	FCGR2A	176	P12318
FSIPQANHSHSGDYH	FCGR2B	181	P31994
ANHSHSGDYHCTGNI	FCGR2B	186	P31994
KEEHHYSAAFQIGGH	C14orf28	261	Q4W4Y0
SEGHSYQNSGLDHFQ	ARFGAP1	306	Q8N6T3
TSGDHHIFNKTSHGY	CCSER1	421	Q9C0I3
EQSVDRSGHSGYHHS	FLG	1506	P20930
YSYSHNGTLHGFVNH	ANO2	836	Q9NQ90
TDNFHGGHFEIHFNQ	ACAD11	591	Q709F0
GGDLHYHLSQHGVFS	GRK2	276	P25098
DHGNGTFSVYFRHNS	NXPH2	136	O95156
HYSHTGQDGQAAFSK	RBM20	266	Q5T481
EGDHHGHSFDSNSFG	IMMP2L	121	Q96T52
IDLHTVHFHGHSFQY	CP	991	P00450
VHFHGHSFQYKHRGV	CP	996	P00450
EHTYHQGGVHSSLLT	NPHS1	891	O60500
HESRSHQSSYGQHGS	FLG2	836	Q5D862
GQHESRSHQSSYGQH	FLG2	911	Q5D862
TGHVNYIHGSSQAQF	MAGT1	251	Q9H0U3
TFNTAVYHPHGLNHG	MUC21	511	Q5SSG8
SGQHFAAELHIVHYN	CA12	136	O43570
SSGFQDAGHREQAYH	MAP3K6	366	O95382
FSIPQANHSHSGDYH	FCGR2C	181	P31995
ANHSHSGDYHCTGNI	FCGR2C	186	P31995
HTDQVLHLSFSHSGY	FBXW5	91	Q969U6
GTAEHPYHTFSAHQS	PCSK6	631	P29122
TNEAGFSHSHQHGFG	PCSK7	451	Q16549
GFYGNLSSQRHVNDH	FAT2	3836	Q9NYQ8
VHTSFHGVGHDYVQL	PGM2L1	261	Q6PCE3
LYGTSATLEHHHFNH	PDE11A	726	Q9HCR9
AIHDYEHTGTTNSFH	PDE1B	261	Q01064
AIHDYEHTGTTNNFH	PDE1C	266	Q14123
LNNYQRATGHGEHFS	ENDOU	206	P21128
YFHHQTLGQTGSFAV	FRYL	2951	O94915
HGDLTFQHVFHNHTY	NFE2L3	486	Q9Y4A8
SYGQHESASHHASGR	HRNR	866	Q86YZ3
QHGSGSGHSSSYEQH	HRNR	946	Q86YZ3
QHESGSGHSSAYSQH	HRNR	1286	Q86YZ3
QHGSGSGHSSSYEQH	HRNR	1416	Q86YZ3
QHESGSGHSSAYSQH	HRNR	1756	Q86YZ3
QHGSGSGHSSSYEQH	HRNR	1886	Q86YZ3
QHESGSGHSSAYSQH	HRNR	2226	Q86YZ3
QHGSGSGHSSSYEQH	HRNR	2356	Q86YZ3
QHESGSGHSSAYSQH	HRNR	2696	Q86YZ3
EHHFQTSCKGASHYG	LNX1	121	Q8TBB1
HHTHYPQFSGQSFAE	ARSA	226	P15289
HHSYGQEHQSLALAT	HOXA1	161	P49639
YNGGTSAAAAGHHHH	NLK	16	Q9UBE8
ESGGFGSHHHNQNYC	PCDH10	806	Q9P2E7
GLGHHDDYTQNHSFQ	PLEKHM3	326	Q6ZWE6
HSFFDHGYNHLVDQN	HPSE2	421	Q8WWQ2
QHLNFSQVQHFGSGH	HIPK3	1051	Q9H422
ESSHDDHQSYQGHPA	IKZF2	411	Q9UKS7
HHKTEFGSNLTGHGY	DTX1	581	Q86Y01
HGHHEGVAYQALTEA	ALPI	336	P09923
AADHTLGNSSGHYIF	MALRD1	1341	Q5VYJ5
SGHYAVAQTQDHHQE	CLDN22	196	Q8N7P3
PHSSHQISFTFYGHA	HYDIN	1341	Q4G0P3
GNHHTRETHFNNLYS	BLM	1011	P54132
NHSYGHSDADVLHQS	DOCK9	1376	Q9BZ29
KHSTVNGHYHNGILN	UGT8	511	Q16880
GTGHSLQQVTGHDHY	C17orf98	101	A8MV24
DGHQSSHGDIFSHFF	DNAJB11	96	Q9UBS4
ATHVHFDHSGGLYQF	MBLAC2	81	Q68D91
FFGQHGGESQHTIHA	MAN2C1	241	Q9NTJ4
DHNGNTALHYSVSHS	KANK4	821	Q5T7N3
GFSRVHIYHHTGNNT	ENAH	31	Q8N8S7
HIYHHTGNNTFRVVG	ENAH	36	Q8N8S7
PSHIYGGHSSHVTNV	EML1	776	O00423
SHKYGGHSSHVTNVA	EML2	611	O95834
QLQHHDTTHEAATYG	KCTD3	631	Q9Y597
FHANGTDVGFDLHHG	MEX3B	241	Q6ZN04
QLHTGASHAARNHYE	SQOR	31	Q9Y6N5
NAEYHTGLHTGHSFQ	TPSD1	196	Q9BZJ3
SYGNSDNTHGGDHHS	XG	116	P55808
DNTHGGDHHSTYGNP	XG	121	P55808
GDHVSQTHSFLHPSY	SKIL	386	P12757
YHSFSEQSFHANNGH	SLC41A2	86	Q96JW4
ALQHAHAHSSGYFIT	INIP	71	Q9NRY2
ATYHVDRSGNVHHQF	SERPINB3	71	P29508
LYFAHHNLFHEGSNS	TLR1	711	Q15399
DTFEHGGGHSYNHKQ	SOX6	351	P35712
YAVEPFHQGHHSVDT	TCN2	181	P20062
STCDGLRGYFTHHHQ	ADAMDEC1	141	O15204
DVHGFNSYGSHRTLQ	PKP3	296	Q9Y446
NHHGTLESGHYTSFI	USP51	656	Q70EK9
EYNNIQHLFSHSLHG	TLR3	306	O15455
VHFYGHVEHTSQGAK	PYGM	201	P11217
HSHFILVDDGTHGQY	TRPM2	281	O94759
FEVSTSEHGAQHHVY	TEAD3	416	Q99594
HTGTLQRHQSYHIGD	ZNF808	86	Q8N4W9
ATYHVDRSGNVHHQF	SERPINB4	71	P48594
AYQGAGFVHNHFSDS	PLCH1	1436	Q4KWH8
RYLHVEGGNFHASSQ	RBPJ	201	Q06330
LYFAHHNLFHEGSNN	TLR6	716	Q9Y2C9
GYSSLQAHHRVHTGE	ZNF112	816	Q9UJU3
HHPGHVGSYSSAAFN	ZIC1	81	Q15915
LSQLLGHHHSVFYSS	UBE3B	801	Q7Z3V4
SYHNSFQTHERLHTG	ZNF443	151	Q9Y2A4
DHYSHKANGQHEISF	ZNF148	546	Q9UQR1
HVAGGQLHAAYSHLT	VSIG10L2	126	P0DP72
HAVLVHSGDNHGGHY	USP7	451	Q93009
YQYSQRSQAGHTLHH	PKP2	166	Q99959
DGNFHQSSGVHFHQR	ZNF214	281	Q9UL59
IGHGQVFTQNSSYSH	ZNF81	221	P51508
IIVGSHHHTAHSYNG	NAALADL2	446	Q58DX5
SGSAGQYGSDQQHHL	MYOZ1	121	Q9NP98