Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaldehyde dehydrogenase (NAD+) activity

ALDH2 ALDH1A3

1.10e-0415212GO:0004029
GeneOntologyMolecularFunctionaldehyde dehydrogenase [NAD(P)+] activity

ALDH2 ALDH1A3

1.42e-0417212GO:0004030
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

ALDH2 ALDH1A3

1.15e-0348212GO:0016620
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors

ALDH2 ALDH1A3

1.57e-0356212GO:0016903
GeneOntologyMolecularFunctionNAD binding

ALDH2 ALDH1A3

2.65e-0373212GO:0051287
GeneOntologyBiologicalProcesspositive regulation of integrin-mediated signaling pathway

PCSK5 LIMS1

7.27e-0514192GO:2001046
MousePhenoincreased thoracic vertebrae number

PCSK5 ACVR2B

6.23e-0510172MP:0004651
MousePhenoincreased presacral vertebrae number

PCSK5 ACVR2B

1.08e-0413172MP:0000464
DomainLIM

LIMS4 LMO3 LIMS3 LIMS1

7.90e-0769204PF00412
DomainLIM_DOMAIN_2

LIMS4 LMO3 LIMS3 LIMS1

8.87e-0771204PS50023
DomainZnf_LIM

LIMS4 LMO3 LIMS3 LIMS1

8.87e-0771204IPR001781
DomainLIM_DOMAIN_1

LIMS4 LMO3 LIMS3 LIMS1

8.87e-0771204PS00478
DomainLIM

LIMS4 LMO3 LIMS3 LIMS1

8.87e-0771204SM00132
DomainTCR

TESMIN LIN54

1.09e-062202PF03638
DomainLin-54_fam

TESMIN LIN54

1.09e-062202IPR028307
DomainCRC

TESMIN LIN54

1.09e-062202PS51634
DomainCRC

TESMIN LIN54

1.09e-062202IPR005172
DomainPINCH

LIMS4 LIMS1

3.27e-063202IPR017351
DomainEGF

PCSK5 LAMA3 LRP1B AREG ZAN

4.02e-06235205SM00181
DomainEGF-like_dom

PCSK5 LAMA3 LRP1B AREG ZAN

5.33e-06249205IPR000742
DomainTesmin/TSO1-like_CXC

TESMIN LIN54

1.63e-056202IPR033467
DomainCXC

TESMIN LIN54

1.63e-056202SM01114
Domain-

LIMS4 LMO3 LIMS1

5.49e-05702032.10.110.10
DomainAld_DH_CS_GLU

ALDH2 ALDH1A3

1.30e-0416202IPR029510
DomainEGF_1

LAMA3 LRP1B AREG ZAN

1.38e-04255204PS00022
DomainAld_DH_CS_CYS

ALDH2 ALDH1A3

1.47e-0417202IPR016160
DomainEGF-like_CS

LAMA3 LRP1B AREG ZAN

1.51e-04261204IPR013032
DomainEGF_2

LAMA3 LRP1B AREG ZAN

1.60e-04265204PS01186
DomainALDEHYDE_DEHYDR_GLU

ALDH2 ALDH1A3

1.65e-0418202PS00687
DomainALDEHYDE_DEHYDR_CYS

ALDH2 ALDH1A3

1.65e-0418202PS00070
Domain-

ALDH2 ALDH1A3

1.84e-04192023.40.605.10
DomainAldedh

ALDH2 ALDH1A3

1.84e-0419202PF00171
DomainAldehyde_DH_dom

ALDH2 ALDH1A3

1.84e-0419202IPR015590
Domain-

ALDH2 ALDH1A3

1.84e-04192023.40.309.10
DomainAld_DH_C

ALDH2 ALDH1A3

1.84e-0419202IPR016163
DomainAld_DH_N

ALDH2 ALDH1A3

1.84e-0419202IPR016162
DomainAld_DH/histidinol_DH

ALDH2 ALDH1A3

1.84e-0419202IPR016161
DomainEGF

LRP1B AREG ZAN

3.14e-04126203PF00008
DomainGrowth_fac_rcpt_

PCSK5 LAMA3 LRP1B

5.87e-04156203IPR009030
DomainEGF_3

LRP1B AREG ZAN

1.91e-03235203PS50026
PathwayKEGG_HISTIDINE_METABOLISM

ALDH2 ALDH1A3

3.14e-0429132M12524
PathwayWP_ETHANOL_EFFECTS_ON_HISTONE_MODIFICATIONS

ALDH2 ALDH1A3

3.60e-0431132M39714
Pubmed

Characterization of cardiac-resident progenitor cells expressing high aldehyde dehydrogenase activity.

ALDH2 ALDH1A3

2.08e-06421223484127
Pubmed

ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools.

ALDH2 ALDH1A3

1.90e-051121223142317
Pubmed

Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.

PCSK5 LAMA3

7.24e-052121222959728
Pubmed

Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems.

ALDH2 ALDH1A3

8.72e-052321218971422
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

RNF31 PCSK5 LMO3 AREG

4.37e-0460821416713569
InteractionTRIM49C interactions

LIMS4 LIMS3

1.96e-057202int:TRIM49C
InteractionIGFL3 interactions

PCSK5 LAMA3 LRP1B

5.39e-0575203int:IGFL3
CytobandEnsembl 112 genes in cytogenetic band chr2q13

LIMS4 LIMS3

3.36e-0459212chr2q13
Cytoband2q13

LIMS4 LIMS3

4.46e-04682122q13
GeneFamilyLIM zinc finger domain containing|LIM domain containing

LIMS4 LIMS3 LIMS1

3.31e-0941831163
GeneFamilyLIM domain containing

LMO3 LIMS3 LIMS1

2.60e-05591831218
GeneFamilyAldehyde dehydrogenases

ALDH2 ALDH1A3

1.58e-0419182398
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3-Excitatory_Neuron.Slc17a7.Pvrl3-Fos_(CA3_Principal_cells)|Hippocampus / BrainAtlas - Mouse McCarroll V32

SPINK13 TESMIN AREG ALDH1A3

5.42e-0880214b661644806e225f215047e78ae46d7cee6efde4f
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TESMIN EVPL ALDH2 ACVR2B

1.29e-06176214d43d9e86c4d4fa1e88fbf2b899ac7143717aac90
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Nxph2_Wls|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PCSK5 LRP1B LMO3

3.02e-0513021305d5a73acf1d7f75a79876b1a06d27c74a89b8a4
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_7|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

EVPL AREG ALDH2

3.61e-05138213c172880eda7b8b8b758dbbc77f93191238f3181c
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_7|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

EVPL AREG ALDH2

3.68e-05139213313f7e66ed94950129c7146a2afe2feb8951fe1e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPINK13 AREG ALDH1A3

3.93e-051422136469cf82552b39f63e20b841c9eed50de6f58d54
ToppCellAdult-Immune-mast_cell-D122|Adult / Lineage, Cell type, age group and donor

TESMIN LRP1B AREG

5.10e-051552137c9de0591d1bf756b8e268b278bbe10bd5415dcd
ToppCell356C-Myeloid-Macrophage-SPP1+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

PCSK5 DTNB ACVR2B

6.03e-05164213d6806deabf5f5c355934387be2baae125ac33fb8
ToppCell10x3'2.3-week_17-19-Myeloid_DC-DC-tDC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

LRP1B ALDH2 ZAN

6.82e-05171213b327fb7813a3cdae06c8a4f8a0c256e9a20132f6
ToppCellAT1-AT2_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

LAMA3 EVPL ALDH1A3

6.94e-051722130be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_12|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LRP1B AREG ALDH2

7.06e-051732139c7386bf0a899882c733f0b4921a96afde032a7d
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_12|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LRP1B AREG ALDH2

7.06e-05173213a55f310c533432e9e26e400026a5b47245152976
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TESMIN ALDH2 ACVR2B

7.18e-05174213a9f34d1237f335d27c5560ff514368f4709f9144
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TESMIN EVPL ALDH1A3

7.43e-051762138d9d0fb46c418b2067be58aec822e8c2b1561461
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMA3 LMO3 ALDH1A3

7.56e-051772136b4fe717928814dafcd13090b1c90ea973938c6d
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

EVPL LYNX1 ALDH1A3

7.81e-051792132b5f8e109a67c7fc3ec2b83e8f1854160c99283a
ToppCell10x3'2.3-week_14-16-Myeloid_DC-DC-tDC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LRP1B AREG ALDH2

7.94e-051802133d9f3e6f13e558279b4ef43e2c44c7c50d761745
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic-DC2|bone_marrow / Manually curated celltypes from each tissue

LRP1B AREG ALDH2

8.34e-05183213f482e4fe011fa450a475034b1e25587233855bdb
ToppCellCOVID-19-lung-AT1|COVID-19 / Disease (COVID-19 only), tissue and cell type

LAMA3 EVPL LMO3

8.34e-051832137b1a385ed54f93bfe85bf0c162e42d05d516b45c
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 LRP1B ALDH1A3

8.75e-051862132d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1B LMO3 ALDH1A3

8.75e-051862137582b5154d8e5a4434817b5ab77a10b789ea2288
ToppCellPCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

LAMA3 EVPL LMO3

9.03e-051882130d86044bc340e3efb90d0022dd299873639d831c
ToppCell10x3'2.3-week_17-19-Myeloid_DC-DC-DC_precursor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

LRP1B ALDH2 ZAN

9.03e-05188213c1b8682f2edb45d51bf91ebf429dff1cb57a7a73
ToppCell10x3'2.3-week_14-16-Myeloid_DC-DC-DC2|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LRP1B AREG ALDH2

9.03e-0518821315d8dc514d5da46f6af284e7c1c92c606712dae6
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

LAMA3 LMO3 DTNB

9.47e-05191213ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

LAMA3 LMO3 AREG

9.62e-0519221325378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1B ALDH2 ALDH1A3

9.62e-051922138ad6678df89175c5a4a835c8566f1552df3c996e
ToppCellPCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

LAMA3 LMO3 AREG

9.62e-05192213450baeb5c3df7a9445472530002ce38f177a333c
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1B ALDH2 ALDH1A3

9.62e-051922132f5378ea0b2fb2f672a36585d375f675983363a1
ToppCelldistal-Hematologic-Basophil/Mast_2-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TESMIN EVPL AREG

9.76e-05193213f22d0a2ea6bbdd625909ccb6a89aca89ab670306
ToppCellLA|World / Chamber and Cluster_Paper

PCSK5 LRP1B LMO3

9.76e-05193213d4bf89437216baf489ea0239136dcedf3b6714af
ToppCellFetal_29-31_weeks-Epithelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

LAMA3 LMO3 DTNB

9.76e-05193213a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCelldistal-Hematologic-Basophil/Mast_2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TESMIN EVPL AREG

9.76e-05193213dcdc1498726c68bf590bf84cb81e5f7fb7ba4d78
ToppCelldistal-3-Hematologic-Basophil/Mast_2|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TESMIN EVPL AREG

9.76e-0519321323c6c798525dad43eff792727902ea562bf373be
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PCSK5 LIN54 AREG

9.91e-051942136be74e4ba631b0c46cef2c580553f4c1ed29579e
ToppCellNS-critical-d_0-4-Epithelial-Squamous|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EVPL LYNX1 ALDH1A3

9.91e-05194213614d0c25b56957c70f397abb169fd2a860eb1c06
ToppCell10x5'v1-week_14-16-Myeloid_DC-DC-DC2|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LRP1B AREG ALDH2

9.91e-05194213a0cfc8c1cdc0722db39170e4417615b6e6b85041
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1B LMO3 ALDH1A3

9.91e-0519421369bff17df4a760ccf081cf52ff04af02c14f448d
ToppCellLA-14._Fibroblast_III|World / Chamber and Cluster_Paper

PCSK5 LMO3 ALDH1A3

9.91e-05194213803fa83ceada17c38ca9f933b888f7e7b0b90761
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LMO3 AREG ACVR2B

9.91e-0519421354975e663ed4414b99b3c9a1aa6335613946470f
ToppCell10x5'v1-week_17-19-Myeloid_DC-DC-DC2|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

LRP1B AREG ALDH2

9.91e-05194213833c695779edc94690b08814b0dedcf00ae082cd
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

LAMA3 EVPL AREG

9.91e-05194213c47fc3f716ab091a39c20d7639ac783029589ee5
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

LAMA3 EVPL AREG

1.01e-0419521362d369a8af2b76a2553bc8ff9cb89a133b060123
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-B|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LIMS4 AREG ALDH2

1.01e-041952132394e75cf493d8bc2e638ecb425386265176dd41
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRP1B LMO3 ALDH1A3

1.04e-0419721317344464fdcc5ba0c03959696b97c195f11e644c
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

LAMA3 EVPL AREG

1.04e-041972136852a8ec1397811bbdd1fc625c52ed4fa75a931e
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal-mesenchymal_stem_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRP1B LMO3 ALDH1A3

1.04e-041972133bb92dd8a94e2be3b7fe51c9a21b241215477ac7
ToppCelltumor_Lung-Epithelial_cells-tS1|Epithelial_cells / Location, Cell class and cell subclass

LMO3 AREG ALDH2

1.04e-041972137190143468939cf26c069d125a5e88e4bf026299
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRP1B LMO3 ALDH1A3

1.04e-041972135b8d0d7116b20d8e27541e88ec80c9f1f477e384
ToppCelldistal-Epithelial-Club-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

EVPL LMO3 AREG

1.05e-04198213e56a5ffadfa4d1e34d34aec43eaf560cd80286e1
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LMO3 ALDH2 ALDH1A3

1.05e-041982130d9d401190792fd61434f1b82548253187d805f0
ToppCellBronchial-10x5prime-Epithelial-Epi_alveolar-AT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA3 EVPL LMO3

1.05e-0419821354228dd9a50616d2022712d162a419ed0327cabd
ToppCellPCW_13-14-Epithelial|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

LAMA3 EVPL AREG

1.05e-0419821348eb6f69a464a34ab32e8d425a22b9d45ec20428
ToppCellParenchymal-10x5prime-Epithelial-Epi_alveolar-AT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA3 EVPL LMO3

1.07e-04199213aca81a879ef9c196bd1885eff4c63ffe6c9682b7
ToppCelldistal-Epithelial-Club|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

EVPL LMO3 AREG

1.07e-04199213c63ccce1285352927fd8c4f7374ec5fff8d70cec
ToppCell(05)_Secretory-(2)_GFP_FOXI1|(05)_Secretory / shred by cell type by condition

LIMS1 AREG ALDH1A3

1.07e-04199213d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCellsevere-cDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LRP1B AREG ALDH2

1.08e-0420021323e3d2fb86a71f62cca32640842fbba5dd163453
ToppCellCalu_3|World / Cell line, Condition and Strain

LAMA3 AREG ALDH1A3

1.08e-04200213a549aa08aeefe905653266dae3936094ff55f8e4
ToppCellBiopsy_Other_PF-Epithelial-Transitional_AT2|Biopsy_Other_PF / Sample group, Lineage and Cell type

LAMA3 EVPL LMO3

1.08e-042002131ba6327851aa61e9a1f1fe1671bc27929d93ac74
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Kctd12-Inhibitory_Gad1Gad2Slc17a8_Htr3a.Ktcd12_(Interneuron,__GABA/Glutamate_co-releasing?_(candidate_CGE-derived_9))|Hippocampus / BrainAtlas - Mouse McCarroll V32

ACVR2B ZAN

4.11e-04642123e3eed30abcecd3fc8d30489dca05222ac353180
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Kctd12|Hippocampus / BrainAtlas - Mouse McCarroll V32

ACVR2B ZAN

4.11e-04642122edc3ae3e334bb04a411778e3b102b3a84a97824
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Kctd12-Inhibitory_Gad1Gad2Slc17a8_Htr3a.Ktcd12_(Interneuron,__GABA/Glutamate_co-releasing?_(candidate_CGE-derived_9))-|Hippocampus / BrainAtlas - Mouse McCarroll V32

ACVR2B ZAN

4.11e-0464212b8aac6e83c2e5b09b55ea22ddb29940099f186e1
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P1-Tnr-Polydendrocyte.Tnr.Pdgfa-Pik3r3_(Pdgfa)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TESMIN ACVR2B

5.06e-04712122220e1b02baa71961cfc85536bafeb313e588bf3
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P1-Tnr-Polydendrocyte.Tnr.Pdgfa-Pik3r3_(Pdgfa)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TESMIN ACVR2B

5.06e-0471212cc5de8bbcfefa2bf93cc137c74b49a745d5da229
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Fezf2-Excitatory_Neuron.Slc17a7-Slc17a8.Fezf2-Slc17a8_(Layer_5,_Retrosplenial_cortex_(RSG)_and_Subiculum,_Tshz2+)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

AREG ACVR2B

5.20e-0472212e3f4d1df43cc41b0424f27485a00ddca9e905f95
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

LAMA3 ZAN

6.90e-04832123aa95bf2d8ac37e648037faf3d54ebb243a4fde1
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

LAMA3 ZAN

6.90e-048321270804dd63221dd5ed26068ec1b50f11875abbc50
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)|Cerebellum / BrainAtlas - Mouse McCarroll V32

LAMA3 ZAN

6.90e-0483212c1818411438f53aec76afead5c8caab701b95d39
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2|Cerebellum / BrainAtlas - Mouse McCarroll V32

LAMA3 ZAN

6.90e-04832121e7af8aaa20b4c2a77cf2f330113db0faa9d483c
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

TESMIN ACVR2B

7.07e-0484212c37e1170d39ad015f724e373a547ea5b6ba45a84
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

TESMIN ACVR2B

7.07e-04842127e4a76b65b0d34d9950f8b02590ff5a4b4534a27
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE-P2-Tnr|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

TESMIN ACVR2B

7.07e-0484212503490e9408d9638bcd089ef8ec0521924df9a5d
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE-P2|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

TESMIN ACVR2B

7.07e-04842121f8b19b159f83655f66cb99f8d10d9a87c08f78f
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Col15a1_(Col15a1)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TESMIN ADAM5

8.47e-0492212926e02725a03d8473eda25d4aef63e34a6566224
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Col15a1_(Col15a1)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TESMIN ADAM5

8.47e-0492212d2c1d25e5bb6ba4f406e916e3c0a5ad05492e59d
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Slc17a7.Cplx3_(Cortical_subplate)|Striatum / BrainAtlas - Mouse McCarroll V32

SPINK13 PCSK5

1.08e-0310421259e982b521610af0532c63b2caf934fa65644b0b
ToppCellCOVID-19-Heart-Fib_+_CM|Heart / Disease (COVID-19 only), tissue and cell type

LMO3 ALDH1A3

1.08e-031042120b60a56a46f1fe3f8224ec6399d009a34a117a21
ToppCellControl-B_naive-4|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

PCSK5 LRP1B

1.08e-031042125f72aa686b0fb83d401621e1b9d9c69e56105570
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Slc17a7.Cplx3_(Cortical_subplate)--|Striatum / BrainAtlas - Mouse McCarroll V32

SPINK13 PCSK5

1.08e-031042127642c6ac1a51b431a8d48d35520930c072a3710e
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Slc17a7.Cplx3_(Cortical_subplate)-|Striatum / BrainAtlas - Mouse McCarroll V32

SPINK13 PCSK5

1.08e-03104212016704f1d1c43e6d4067ad1d81c22cc660e605d0
ToppCell343B-Myeloid-Dendritic-cDC2|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

LIMS1 ALDH2

1.19e-031092126e90d04c5094c7410d667dae80de3279bddd24bd
ToppCellPND07-28-samps-Myeloid-Macrophage-macrophage-A|PND07-28-samps / Age Group, Lineage, Cell class and subclass

TESMIN EVPL

1.25e-03112212d21cfcb04a27cc9fb74e0c2afa8a8cdfb886ae21
ToppCell(05)_Ciliated-(3)_72hpi|(05)_Ciliated / shred by cell type and Timepoint

TESMIN ADAM5

1.27e-03113212eaa5bc8f8183b353ee1e7618e99220eb3684cd60
ToppCellControl-B_naive-4|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

PCSK5 LRP1B

1.34e-0311621235d471c8dbf408d0be3837c428d9c2a73c805a6f
ToppCell356C-Myeloid-Macrophage-SPP1+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

PCSK5 ACVR2B

1.55e-0312521243aa4b77dccf0ea2979218826af16034f2017c3a
ToppCell390C-Lymphocytic-NK_cells-NK_cell_B1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

LYNX1 ACVR2B

1.58e-0312621210e1448a03f79965b72922fd83ef51de1b7b474f
ToppCellGlobus_pallidus|World / BrainAtlas - Mouse McCarroll V32

ACVR2B ZAN

1.58e-0312621244b63f945d5bedf1a2ca1810e7e100276ea9dd89
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMA3 LMO3

1.60e-031272125b0adbcafad31a6759c9bdce2f7f9591a8edc450
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMA3 LMO3

1.68e-031302126434d9106ccb38786dad36fab80163dfc07b6eb7
ToppCellPND01-03-samps-Myeloid-Macrophage-macrophage_-_intermediate_-_unactivated|PND01-03-samps / Age Group, Lineage, Cell class and subclass

TESMIN ADAM5

1.73e-03132212617644597726e881cd343e57f6edb5a98473b421
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMA3 LMO3

1.76e-031332125bf5e654653e2c340891f51e3f2a30441b7b6b2b
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Nxph3|Hippocampus / BrainAtlas - Mouse McCarroll V32

PCSK5 LMO3

1.89e-03138212b63e26afafbd2cdeed9c9451e6f530ab6295504c
ToppCell10x3'2.3-week_12-13-Myeloid_DC-DC-DC2|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

LRP1B ALDH2

1.94e-03140212c3331cb7720f93af8bab35d02c6cbe87dd324d91
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LMO3 ALDH1A3

1.97e-03141212091b5b72811db5fca2314f4a79d467566920e257
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6b|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PCSK5 LMO3

1.97e-031412125ef3166c5271aa90fd0633016edfe2c74b835319
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1B LMO3

2.05e-031442125665dd2839b6c8ddbf5ddb2d22e1ee6073f74c3b
ToppCell10x3'2.3-week_12-13-Myeloid_DC-DC-tDC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

LRP1B ALDH2

2.08e-03145212a6c291811bf62f1c13f1b4b396d75c2223cf1c7d
ToppCellSevere-Myeloid-Mast-|Severe / Condition, Lineage, Cell class and cell subclass

LRP1B AREG

2.08e-03145212ce307d45425a5191882078f049f85477eec40b69
ToppCellSevere-Myeloid-Mast|Severe / Condition, Lineage, Cell class and cell subclass

LRP1B AREG

2.08e-03145212e0bfd2ffdbd6c197ef0a04e983396ebd87ef7127
ComputationalNeighborhood of CDH3

LAMA3 AREG ALDH1A3

5.05e-0627143GNF2_CDH3
ComputationalNeighborhood of SERPINB5

LAMA3 AREG ALDH1A3

5.65e-0628143GNF2_SERPINB5
ComputationalIntermediate filaments and MT.

LAMA3 EVPL DTNB

8.39e-0568143MODULE_438
ComputationalIntermediate filaments.

LAMA3 AREG ALDH1A3

1.12e-0475143MODULE_154
ComputationalGenes in the cancer module 297.

LAMA3 AREG ALDH1A3

1.36e-0480143MODULE_297
ComputationalIntermediate filaments and keratins.

LAMA3 AREG ALDH1A3

1.36e-0480143MODULE_357
ComputationalBreast cancer expression clusters.

EVPL ZMYM1

8.13e-0433142MODULE_366
ComputationalGenes in the cancer module 153.

LAMA3 EVPL

8.63e-0434142MODULE_153
ComputationalGenes in the cancer module 285.

EVPL ZMYM1

1.79e-0349142MODULE_285
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

LAMA3 AREG

1.86e-0350142GAVISH_3CA_METAPROGRAM_EPITHELIAL_EPI3
DrugNSC350854

AREG ZMYM1 ACVR2B ZAN

2.69e-06108214CID000434448
Drugbetaine aldehyde

DTNB ALDH2 ALDH1A3

3.30e-0632213CID000000249
DrugRetinaldehyde

AREG ALDH2 ALDH1A3

7.59e-0642213ctd:D012172
Drug3-butynoate

ALDH2 ALDH1A3

1.70e-057212CID000137547
Drug3-butynal

ALDH2 ALDH1A3

1.70e-057212CID000142966
DrugC04554

ALDH2 ALDH1A3

2.26e-058212CID000440384
DrugKaempferol [520-18-3]; Down 200; 14uM; MCF7; HT_HG-U133A

RNF31 LAMA3 EVPL ACVR2B

2.73e-051942147196_DN
DrugCPD 30

ALDH2 ALDH1A3

2.91e-059212CID000440850
Drug4-acetamidobutyrate

ALDH2 ALDH1A3

2.91e-059212CID000018189
Drugsuccinic semialdehyde

DTNB ALDH2 ALDH1A3

3.41e-0569213CID000001112
Drugsulfenic acid

EVPL DTNB ALDH2

3.41e-0569213CID000447586
Drugynoate

ALDH2 ALDH1A3

4.43e-0511212CID000010110
DrugAC1L1J0I

ALDH2 ALDH1A3

5.32e-0512212CID000030201
Drugimidazole acetaldehyde

ALDH2 ALDH1A3

5.32e-0512212CID000150841
Drug6-[(3R,7R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylheptanal

ALDH2 ALDH1A3

8.45e-0515212CID000440673
Drugglycurone

ALDH2 ALDH1A3

9.65e-0516212CID000003483
Drugtrimethylaminobutyraldehyde

ALDH2 ALDH1A3

1.09e-0417212CID000000133
Drugpropynal

ALDH2 ALDH1A3

1.09e-0417212CID000012222
Drugmethylimidazole acetaldehyde

ALDH2 ALDH1A3

1.09e-0417212CID000193545
DrugN-methylmaleimide

DTNB ALDH2

1.23e-0418212CID000070261
Drug5-HIAL

ALDH2 ALDH1A3

1.37e-0419212CID000074688
Drugtestosterone enanthate

LIMS1 AREG ZMYM1 ALDH1A3 ACVR2B

1.47e-04575215ctd:C004648
Drugperillaldehyde

ALDH2 ALDH1A3

1.68e-0421212CID000016441
Druggamma-aminobutyraldehyde

ALDH2 ALDH1A3

2.40e-0425212CID000000118
Drugglyceraldehyde

DTNB ALDH2 ALDH1A3

2.79e-04140213CID000000751
Drugindole-3-acetaldehyde

ALDH2 ALDH1A3

3.02e-0428212CID000000800
Drugnonanal

PCSK5 ALDH2

3.24e-0429212CID000031289
Drug3,4-dihydroxyphenylacetaldehyde

ALDH2 ALDH1A3

3.47e-0430212CID000119219
Drug3-aminopropanal

ALDH2 ALDH1A3

3.47e-0430212CID000000075
Drugdecanal

ALDH2 ALDH1A3

3.71e-0431212CID000008175
Drugperillic acid

ALDH2 ALDH1A3

3.71e-0431212CID000001256
Drugmethylmalonate semialdehyde

ALDH2 ALDH1A3

3.95e-0432212CID000000296
Drugglyceraldehyde-3-phosphate

DTNB ALDH2 ALDH1A3

4.05e-04159213CID000000729
Drugalpha-neoendorphin

PCSK5 LAMA3

4.20e-0433212CID005311003
Drugoctanal

ALDH2 ALDH1A3

5.29e-0437212CID000000454
Drugalpha-CDs

LAMA3 ALDH2

6.50e-0441212CID000452566
DrugAC1LAR7G

PCSK5 DTNB

6.50e-0441212CID000493598
Druggamma-butyrobetaine

ALDH2 ALDH1A3

6.82e-0442212CID000000134
DrugSelegiline hydrochloride [14611-52-0]; Up 200; 17.8uM; MCF7; HT_HG-U133A

TESMIN LMO3 ALDH2

7.13e-041932134146_UP
DrugScopolamin-N-oxide hydrobromide [6106-81-6]; Down 200; 10uM; PC3; HT_HG-U133A

RNF31 ZMYM1 ALDH2

7.45e-041962132099_DN
DrugLoxapine succinate [27833-64-3]; Down 200; 9uM; MCF7; HT_HG-U133A

LAMA3 EVPL ACVR2B

7.45e-041962135293_DN
DrugRolitetracycline [751-97-3]; Up 200; 7.6uM; MCF7; HT_HG-U133A

TESMIN LAMA3 ACVR2B

7.45e-041962135331_UP
Drugcelecoxib; Down 200; 10uM; MCF7; HG-U133A

DTNB LIMS1 ALDH2

7.68e-04198213252_DN
Drug(-)-quinpirole hydrochloride; Down 200; 1uM; MCF7; HG-U133A

EVPL ALDH2 ACVR2B

7.79e-04199213456_DN
DrugAcetazolamide [59-66-5]; Up 200; 18uM; MCF7; HT_HG-U133A

RNF31 ALDH2 ACVR2B

7.79e-041992137461_UP
DrugMeprylcaine hydrochloride [956-03-6]; Up 200; 14.8uM; MCF7; HT_HG-U133A

TESMIN DTNB ALDH2

7.79e-041992133544_UP
Drughexanal

ALDH2 ALDH1A3

8.54e-0447212CID000006184
Drugimidazole-4-acetic acid

ALDH2 ALDH1A3

8.91e-0448212CID000096215
Diseasevisceral heterotaxy (implicated_via_orthology)

PCSK5 ACVR2B

2.06e-0437172DOID:0050545 (implicated_via_orthology)
DiseaseAsthma

AREG ALDH2

9.61e-0480172C0004096
Diseasetea consumption measurement

LMO3 ALDH2

2.47e-03129172EFO_0010091
Diseaseparental longevity

PCSK5 LRP1B ALDH2

2.66e-03494173EFO_0007796
DiseaseTakayasu arteritis

PCSK5 LRP1B

3.23e-03148172EFO_1001857

Protein segments in the cluster

PeptideGeneStartEntry
VCNNFNHCHCEKGYN

ADAM5

366

Q6NVV9
CNAEFQNFCIHGECK

AREG

146

P15514
CAHQGVFFNQGQCCT

ALDH1A3

301

P47895
CASNGHTFQNECFFC

SPINK13

61

Q1W4C9
QCFVCAQCFQQFPEG

LIMS3

96

P0CW19
QCFVCAQCFQQFPEG

LIMS4

96

P0CW20
CFNHSCPDDQFKCQN

LRP1B

881

Q9NZR2
YCDCFANGEFCNNCN

LIN54

536

Q6MZP7
CNNCNCTNCYNNLEH

LIN54

546

Q6MZP7
CFCFGVNNQCHSSHK

LAMA3

1456

Q16787
YFNGQDCQPCHRFCA

PCSK5

776

Q92824
HACAALQNNFQEFCQ

EVPL

701

Q92817
NVYHLDCFACQLCNQ

LMO3

96

Q8TAP4
CHNYQLCQNCFWRGH

DTNB

261

O60941
LDCHVCAYNGDNCFN

LYNX1

21

P0DP58
FASGDFCNNCNCNNC

TESMIN

311

Q9Y4I5
FCNNCNCNNCCNNLH

TESMIN

316

Q9Y4I5
YHEQCFVCAQCFQQF

LIMS1

31

P48059
QAHFALFFNQGQCCC

ALDH2

306

P05091
NPQVYFCCCEGNFCN

ACVR2B

96

Q13705
TQCRHQFCSGCYNAF

RNF31

891

Q96EP0
FHSANNFIMNCCENC

ZMYM1

221

Q5SVZ6
HCIQASSCNCFYNND

ZAN

1086

Q9Y493