Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	starch binding	EPM2A STBD1	6.56e-05	3	94	2	GO:2001070
GeneOntologyMolecularFunction	G-protein beta-subunit binding	CCT5 RGS11 GNG3	2.16e-04	25	94	3	GO:0031681
Domain	CBM_20	EPM2A STBD1	7.18e-05	3	92	2	PF00686
Domain	CBM_2	EPM2A STBD1	7.18e-05	3	92	2	SM01065
Domain	CBM20	EPM2A STBD1	7.18e-05	3	92	2	PS51166
Domain	CBM_fam20	EPM2A STBD1	7.18e-05	3	92	2	IPR002044
Pubmed	Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.	AP2B1 KIAA1217 UPF1 BAIAP2 PLEC MAP3K5	1.68e-06	131	95	6	28634551
Pubmed	Receptor tyrosine kinase EphA5 is a functional molecular target in human lung cancer.	ATM EPHA5	7.38e-06	2	95	2	25623065
Pubmed	Polycystin-1 mitigates damage and regulates CTGF expression through AKT activation during cardiac ischemia/reperfusion.	PKD1 CCN2	7.38e-06	2	95	2	33065236
Pubmed	Involvement of hepatocyte nuclear factor 4 alpha in transcriptional regulation of the human pregnane X receptor gene in the human liver.	NR1I2 HNF4A	7.38e-06	2	95	2	18305375
Pubmed	Suppression of the pregnane X receptor during endoplasmic reticulum stress is achieved by down-regulating hepatocyte nuclear factor-4α and up-regulating liver-enriched inhibitory protein.	NR1I2 HNF4A	7.38e-06	2	95	2	25616597
Pubmed	Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development.	NR1I2 HNF4A	7.38e-06	2	95	2	12774017
Pubmed	Hepatic nuclear factor 4α positively regulates complement C3 expression and does not interfere with TNFα-mediated stimulation of C3 expression in HepG2 cells.	C3 HNF4A	7.38e-06	2	95	2	23628799
Pubmed	Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease.	PKD1 ATM	7.38e-06	2	95	2	33802342
Pubmed	Pregnane X receptor and hepatocyte nuclear factor 4α polymorphisms are cooperatively associated with carbamazepine autoinduction.	NR1I2 HNF4A	7.38e-06	2	95	2	24384557
Pubmed	Hepatocyte nuclear factor 4α negatively regulates connective tissue growth factor during liver regeneration.	CCN2 HNF4A	7.38e-06	2	95	2	32057145
Pubmed	miR-26a attenuates cardiac apoptosis and fibrosis by targeting ataxia-telangiectasia mutated in myocardial infarction.	CCN2 ATM	7.38e-06	2	95	2	31990056
Pubmed	A disease-relevant mutation of SPOP highlights functional significance of ATM-mediated DNA damage response.	SPOP ATM	7.38e-06	2	95	2	33446628
Pubmed	Apoptosis signal-regulating kinase 1 mediates the inhibitory effect of hepatocyte nuclear factor-4α on hepatocellular carcinoma.	HNF4A MAP3K5	7.38e-06	2	95	2	27050273
Pubmed	Speckle-type POZ protein, SPOP, is involved in the DNA damage response.	SPOP ATM	7.38e-06	2	95	2	24451148
Pubmed	Kidney Cyst Lining Epithelial Cells Are Resistant to Low-Dose Cisplatin-Induced DNA Damage in a Preclinical Model of Autosomal Dominant Polycystic Kidney Disease.	PKD1 ATM	7.38e-06	2	95	2	36293397
Pubmed	Ets-1 is essential for connective tissue growth factor (CTGF/CCN2) induction by TGF-β1 in osteoblasts.	ETS1 CCN2	7.38e-06	2	95	2	22539964
Pubmed	ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial.	BIRC3 ATM	7.38e-06	2	95	2	24584352
Pubmed	A human MAP kinase interactome.	SYNPO2 KIAA1549L ANK3 AP2B1 HIPK2 LAMA4 BAIAP2 PLEC MAP3K5	7.66e-06	486	95	9	20936779
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	MED15 MTA3 AP2B1 CCT5 TLN1 CKAP5 ETS1 QRICH1 UPF1 MTREX RSRC2 HSD17B4 DCXR	9.62e-06	1103	95	13	34189442
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MTA3 ANK3 AP2B1 KIAA0319L PKD1 CKAP5 CCN2 EXOC1 QRICH1 ATM BAIAP2 PLEC HSD17B4 TMED4	1.03e-05	1285	95	14	35914814
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	AP2B1 TLN1 CKAP5 UPF1 PLEC MTREX	1.12e-05	182	95	6	31067453
Pubmed	Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.	NR1I2 HNF4A	2.21e-05	3	95	2	15322103
Pubmed	PXR, CAR and HNF4alpha genotypes and their association with pharmacokinetics and pharmacodynamics of docetaxel and doxorubicin in Asian patients.	NR1I2 HNF4A	2.21e-05	3	95	2	17876342
Pubmed	Pregnane X Receptor Represses HNF4α Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells.	NR1I2 HNF4A	2.21e-05	3	95	2	26232425
Pubmed	ETS1 regulates NKX3.1 5' promoter activity and expression in prostate cancer cells.	ETS1 PLEC	2.21e-05	3	95	2	20842667
Pubmed	HNF4α is required for Tkfc promoter activation by ChREBP.	TKFC HNF4A	2.21e-05	3	95	2	38782732
Pubmed	The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha.	NR1I2 HNF4A	2.21e-05	3	95	2	17764444
Pubmed	Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics.	NR1I2 HNF4A	2.21e-05	3	95	2	18056193
Pubmed	Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells.	PKD1 CDH23	2.21e-05	3	95	2	21865467
Pubmed	Genetic susceptibility of intervertebral disc degeneration among young Finnish adults.	CILP KIAA1217	2.21e-05	3	95	2	22107760
Pubmed	Novel interactions of ankyrins-G at the costameres: the muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C.	ANK3 PLEC	2.21e-05	3	95	2	21223964
Pubmed	Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.	HIPK2 ATM	2.21e-05	3	95	2	11780126
Pubmed	Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial.	BIRC3 ATM	2.21e-05	3	95	2	32015491
Pubmed	Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier.	PKD1 HNF4A	2.21e-05	3	95	2	23209428
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	TKFC CCT5 TSR1 TLN1 SLC35E1 C3 UPF1 PLEC HSD17B4 DCXR	2.54e-05	711	95	10	33022573
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	ARNT2 ESAM ADCK2 CCN2 PLEC TEP1	2.79e-05	214	95	6	22199357
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	MPP2 CCT5 TLN1 CKAP5 EXOC1 ATM UPF1 PLEC MTREX	3.17e-05	582	95	9	20467437
Pubmed	Mutated SPOP E3 Ligase Promotes 17βHSD4 Protein Degradation to Drive Androgenesis and Prostate Cancer Progression.	SPOP HSD17B4	4.41e-05	4	95	2	33762355
Pubmed	Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha.	NR1I2 HNF4A	4.41e-05	4	95	2	16825189
Pubmed	The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.	ATM UPF1	4.41e-05	4	95	2	15175154
Pubmed	The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter.	NR1I2 HNF4A	4.41e-05	4	95	2	15919766
Pubmed	Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR is overexpressed in human fetal liver cells.	NR1I2 HNF4A	4.41e-05	4	95	2	22333269
Pubmed	The carbohydrate-binding domain of overexpressed STBD1 is important for its stability and protein-protein interactions.	EPM2A STBD1	4.41e-05	4	95	2	24837458
Pubmed	Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis.	HIPK2 MAP3K5	4.41e-05	4	95	2	27321923
Pubmed	Lafora disease proteins laforin and malin negatively regulate the HIPK2-p53 cell death pathway.	EPM2A HIPK2	4.41e-05	4	95	2	26102034
Pubmed	ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation.	HIPK2 ATM	4.41e-05	4	95	2	11875057
Pubmed	ATM binds to beta-adaptin in cytoplasmic vesicles.	AP2B1 ATM	4.41e-05	4	95	2	9707615
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	MED15 TCAF1 KIAA1549L ARNT2 QRICH1 BAIAP2 RSRC2 TEP1 PCDH17	4.45e-05	608	95	9	16713569
Pubmed	Genetic link between renal birth defects and congenital heart disease.	AP2B1 PKD1 QRICH1	6.16e-05	28	95	3	27002738
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	AP2B1 CCT5 TLN1 CKAP5 UPF1 UBE3C PLEC MTREX HSD17B4	6.43e-05	638	95	9	33239621
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	MED15 AP2B1 TSR1 TLN1 CKAP5 ATM PLEC	7.22e-05	370	95	7	22922362
Pubmed	Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.	HIPK2 ATM	7.34e-05	5	95	2	18536714
Pubmed	Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.	NR1I2 HNF4A	7.34e-05	5	95	2	15933212
Pubmed	Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.	NR1I2 HNF4A	7.34e-05	5	95	2	16455805
Pubmed	c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease.	PKD1 MAP3K5	7.34e-05	5	95	2	34962918
Pubmed	Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.	NR1I2 HNF4A	7.34e-05	5	95	2	15331348
Pubmed	Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease.	ABCA4 C3	7.34e-05	5	95	2	28348233
Pubmed	Combined effects of hepatocyte nuclear factor 4α and constitutive androstane receptor on stable warfarin doses.	CYP4F2 HNF4A	7.34e-05	5	95	2	25356900
Pubmed	Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1.	ATM UPF1	7.34e-05	5	95	2	16086026
Pubmed	Preferential physical and functional interaction of pregnane X receptor with the SMRTalpha isoform.	NR1I2 TXNRD2	7.34e-05	5	95	2	18978041
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	AP2B1 CCT5 TSR1 TLN1 CKAP5 ATM UPF1 PLEC MTREX	7.68e-05	653	95	9	22586326
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	MED15 GGTLC3 HIPK2 CDH23 UBE3C MAP3K5	7.70e-05	257	95	6	30945288
Pubmed	Direct interactions between the heterotrimeric G protein subunit G beta 5 and the G protein gamma subunit-like domain-containing regulator of G protein signaling 11: gain of function of cyan fluorescent protein-tagged G gamma 3.	RGS11 GNG3	1.10e-04	6	95	2	12606627
Pubmed	Protein Kinase D1 regulates focal adhesion dynamics and cell adhesion through Phosphatidylinositol-4-phosphate 5-kinase type-l γ.	TLN1 PKD1	1.10e-04	6	95	2	27775029
Pubmed	Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids.	TLN1 CCN2	1.10e-04	6	95	2	22964303
Pubmed	FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage.	HIPK2 ATM	1.10e-04	6	95	2	22893124
Pubmed	Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.	PPARGC1B HNF4A	1.10e-04	6	95	2	11733490
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	CCT5 TSR1 KIAA1217 TLN1 KIAA0319L CKAP5 BAIAP2 UBE3C PLEC HSD17B4	1.15e-04	853	95	10	28718761
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	SLC25A24 CCT5 TSR1 TLN1 FN3KRP CKAP5 BIRC3 ATM UPF1 UBE3C MTREX HSD17B4 PCYOX1	1.33e-04	1425	95	13	30948266
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	SLC25A24 TKFC MTA3 PUDP AP2B1 CCT5 TLN1 FN3KRP QRICH1 HSD17B4	1.46e-04	878	95	10	37223481
Pubmed	Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice.	PKD1 RYK	1.54e-04	7	95	2	34174014
Pubmed	Genetic predictors of interindividual variability in hepatic CYP3A4 expression.	NR1I2 HNF4A	1.54e-04	7	95	2	19934400
Pubmed	ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.	SPOP ATM	1.54e-04	7	95	2	34144977
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	SLC25A24 MTA3 AP2B1 CCT5 TSR1 KIAA1217 CKAP5 C3 UPF1 BAIAP2 PLEC MTREX	1.62e-04	1257	95	12	36526897
Pubmed	Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.	MTA3 ANK3 ATM	1.68e-04	39	95	3	22802532
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	SYNPO2 STBD1 ANK3 AP2B1 TLN1 ATM PLEC	1.82e-04	430	95	7	35044719
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	NLN MTA3 INTS2 KIAA1217	1.88e-04	103	95	4	10574462
Pubmed	A genome-wide association study of total serum and mite-specific IgEs in asthma patients.	SYNPO2 TLN1	2.05e-04	8	95	2	23967269
Pubmed	NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genes.	NR1I2 HNF4A	2.05e-04	8	95	2	21292004
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	MPP2 SLC25A24 SYNPO2 INTS2 FN3KRP ARNT2 NCOA7 TMED4 EPHA5	2.17e-04	750	95	9	11230166
Pubmed	Characterization of the zinc-induced Shank3 interactome of mouse synaptosome.	MPP2 CCT5 CDH23 BAIAP2	2.33e-04	109	95	4	29111324
Pubmed	Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches.	MED15 SEC24D AP2B1 UBE3C FILIP1L	2.39e-04	202	95	5	29540532
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	MED15 PDE6D ANK3 AP2B1 SLC35E1 CDH23 C3 EXOC1 BAIAP2 PLEC SPAG16 TMED4	2.56e-04	1321	95	12	27173435
Pubmed	Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation.	SEC24D TCAF1 FN3KRP	2.58e-04	45	95	3	34504087
Pubmed	New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice.	NR1I2 HNF4A	2.62e-04	9	95	2	12837957
Pubmed	Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.	NR1I2 HNF4A	2.62e-04	9	95	2	28751364
Pubmed	The chaperonin containing t-complex polypeptide 1 (TCP-1). Multisubunit machinery assisting in protein folding and assembly in the eukaryotic cytosol.	CCT5 TEP1	2.62e-04	9	95	2	7601114
Pubmed	A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1.	KIAA1549L ARL14EP	2.62e-04	9	95	2	10568747
Pubmed	Human ADA3 regulates RARalpha transcriptional activity through direct contact between LxxLL motifs and the receptor coactivator pocket.	NR1I2 TXNRD2	2.62e-04	9	95	2	20413580
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	TCAF1 AP2B1 FN3KRP SLC35E1 SPOP UPF1 TMED4	2.82e-04	462	95	7	31138677
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	TLN1 CKAP5 ETS1 CCN2 PLEC APOL2	3.08e-04	332	95	6	37433992
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	CCT5 TSR1 TLN1 CKAP5 UPF1 PLEC	3.08e-04	332	95	6	32786267
Pubmed	The EHEC-host interactome reveals novel targets for the translocated intimin receptor.	PDE6D BAIAP2	3.28e-04	10	95	2	25519916
Pubmed	Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation.	TLN1 PKD1	3.28e-04	10	95	2	11113628
Pubmed	Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin.	CCT5 TEP1	3.28e-04	10	95	2	7953530
Pubmed	Protein profile of exosomes from trabecular meshwork cells.	TLN1 LAMA4 C3	3.32e-04	49	95	3	21362503
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	NLN TCAF1 CCT5 TLN1 CKAP5 EXOC1 UPF1 BAIAP2 HSD17B4 APOL2 DCXR PCYOX1	3.49e-04	1367	95	12	32687490
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	TCAF1 TKFC AP2B1 CCT5 TSR1 TLN1 UPF1 BAIAP2 PLEC MTREX RSRC2 TMED4	3.58e-04	1371	95	12	36244648
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	CCT5 CKAP5 UPF1 UBE3C MTREX	3.61e-04	221	95	5	29991511
Pubmed	Plasticity and expanding complexity of the hepatic transcription factor network during liver development.	NR1I2 HNF4A	4.00e-04	11	95	2	16912278
Cytoband	Ensembl 112 genes in cytogenetic band chr11q22	CNTN5 MMP27 BIRC3 ATM	7.54e-05	107	95	4	chr11q22
Cytoband	Ensembl 112 genes in cytogenetic band chr7q34	TRBV12-5 HIPK2 ADCK2 TRPV5	6.11e-04	185	95	4	chr7q34
Coexpression	GSE37301_CD4_TCELL_VS_RAG2_KO_NK_CELL_DN	NLN SEC24D MID1IP1 TLN1 ADCK2 ST3GAL2 PLEC	3.69e-06	180	93	7	M8906
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEC24D SYNPO2 KIAA1217 CCN2 PCDH17 FILIP1L EPHA5	9.15e-08	173	95	7	95c723b09254ae7131fe5ba0841472502e83269b
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEC24D SYNPO2 KIAA1217 BIRC3 CCN2 PCDH17 FILIP1L	1.03e-07	176	95	7	72a2a01618ce836bc843395d5095e9090759b4a6
ToppCell	Cerebellum-Endothelial\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SLC25A24 TLN1 ETS1 LAMA4 ESAM CCN2 FILIP1L	2.06e-07	195	95	7	2192fd9b4682054776f0716933aed5a4a9412657
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEC24D SYNPO2 KIAA1217 CCN2 FILIP1L EPHA5	2.21e-06	177	95	6	4c069f0d044a96118090b85ca592a21d6b5d9399
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEC24D SYNPO2 KIAA1217 BIRC3 CCN2 PCDH17	2.29e-06	178	95	6	431e7557b8e8764e16e9e48368ce6bfa3c61561a
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEC24D SYNPO2 KIAA1217 BIRC3 CCN2 PCDH17	2.36e-06	179	95	6	f65889bf1e41396979cce44a5e63f49dea2bbd9b
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEC24D SYNPO2 KIAA1217 BIRC3 CCN2 EPHA5	2.44e-06	180	95	6	b514c55e52b46e8a1a2f09ed2c59a7683367a505
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEC24D SYNPO2 KIAA1217 BIRC3 CCN2 PCDH17	2.68e-06	183	95	6	65f2a5895d166189a095cf7ea9dda171f0419b08
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MPP2 SYNPO2 RGS11 CCN2 PRDM6 FILIP1L	2.77e-06	184	95	6	54e5b63f55b8d6eccad53d389ea9c78f991e1414
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MPP2 SYNPO2 RGS11 CCN2 PRDM6 FILIP1L	2.77e-06	184	95	6	7b5678718719020b52e7c2a7bd9797987defd7ff
ToppCell	Entopeduncular-Endothelial\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SLC25A24 ANGPTL4 LAMA4 ESAM CCN2 FILIP1L	3.14e-06	188	95	6	94774652fd42bad5012356672ffac8b6d2c22d37
ToppCell	Globus_pallidus-Endothelial\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ANGPTL4 ETS1 LAMA4 ESAM CCN2 FILIP1L	3.23e-06	189	95	6	ad7dc9d25edd68fb624380a082c389fe7d640e7d
ToppCell	Control-Endothelial-VE_Venous\|Endothelial / Disease state, Lineage and Cell class	CDH23 BIRC3 NCOA7 CCN2 PCDH17 MAP3K5	3.33e-06	190	95	6	4e30155203b4a8c5e496fcbe9348b67b98ebc625
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 SLCO1C1 KIAA1217 LAMA4 MAP3K5 FILIP1L	3.87e-06	195	95	6	803f714d91f2d97ecbee8c15a5139fd9310f66c7
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CILP ANGPTL4 LAMA4 C3 CCN2 FILIP1L	3.87e-06	195	95	6	47762d9e442fb1f6f0033e3e10f4c6e498d2c081
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 SLCO1C1 KIAA1217 LAMA4 MAP3K5 FILIP1L	3.87e-06	195	95	6	4f70157d42a16ff0259bc24a62803c4df4285c44
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SYNPO2 STBD1 LAMA4 CCN2 PRDM6 FILIP1L	3.99e-06	196	95	6	4740ef6e428f1ccc81fc98c3b868afd38ce60535
ToppCell	COPD-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	PPARGC1B KIAA1217 HIPK2 ESAM BAIAP2 PCDH17	4.11e-06	197	95	6	30dbc05ea66892d2e18ff375ffa86d1db7bc4083
ToppCell	343B-Endothelial_cells-Endothelial-A_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MED15 ARNT2 CDH23 BIRC3 NCOA7 CCN2	4.11e-06	197	95	6	ec92d60f802c9d4bdf9877bed5c0a91a5a5ed5d0
ToppCell	343B-Endothelial_cells-Endothelial-A_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MED15 ARNT2 CDH23 BIRC3 NCOA7 CCN2	4.11e-06	197	95	6	7bec9c1bc8851064eb229324493b47a31201c83c
ToppCell	367C-Epithelial_cells-Epithelial-E_(AT2)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MID1IP1 GGTLC1 ESAM C3 HSD17B4 DCXR	4.23e-06	198	95	6	85215015bb86ada0e871c413a4ecdc903a3785ca
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SYNPO2 LAMA4 CCN2 PRDM6 RYK FILIP1L	4.23e-06	198	95	6	a699b365d3b6149f13f02b2e2ae9b6fdce761848
ToppCell	367C-Epithelial_cells-Epithelial-E_(AT2)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MID1IP1 GGTLC1 ESAM C3 HSD17B4 DCXR	4.23e-06	198	95	6	38349e42a3f1fb700ff6dfd89c4bf5ff97f1a3e9
ToppCell	LPS_only-Endothelial-Endothelial-Vein\|LPS_only / Treatment groups by lineage, cell group, cell type	KIAA1549L ESAM NCOA7 PLEC PCDH17 FILIP1L	4.48e-06	200	95	6	b036f5e22c95a3b14391785b6e91aa183b9bc9a8
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	KIAA1217 ETS1 ESAM NCOA7 APOL2 FILIP1L	4.48e-06	200	95	6	6f531a418ff25b59a543800cf4bce7b72404ce08
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	KIAA1217 ETS1 LAMA4 ESAM APOL2 PCDH17	4.48e-06	200	95	6	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TKFC NR1I2 CHDH ANGPTL4 HNF4A	2.39e-05	160	95	5	c42bcc6c7d113f0db43febb088b75ca4ac7cb7a3
ToppCell	BL-critical-LOC-Epithelial-FOXN4+\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MPP2 WFIKKN1 SPAG16 GNG3 EPHX3	2.39e-05	160	95	5	3f737451d5713deed20061aa72a9ef77a9a2bc06
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEC24D SYNPO2 KIAA1217 CCN2 PCDH17	3.02e-05	168	95	5	7abaddbcc55e44653d54aa15464266aa6bd5c9d2
ToppCell	droplet-Pancreas-Exocrine-18m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A24 STBD1 CHDH LAMA4 C3	3.11e-05	169	95	5	53690d6f9712b54aa99a0408aae930d64ae478e5
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 LAMA4 CCN2 MAP3K5 FILIP1L	3.20e-05	170	95	5	fa753cc8fbd04e63c9a303da4dc17ee2ce907f92
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 LAMA4 CCN2 MAP3K5 FILIP1L	3.20e-05	170	95	5	03044e1436443b28dd39d5ef4fdb25c18e3a7546
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEC24D SYNPO2 KIAA1217 CCN2 EPHA5	3.20e-05	170	95	5	417b77c12a7982b1ce4b4bc57f30335d261220f5
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 LAMA4 C3 PRDM6 MAP3K5	3.29e-05	171	95	5	5d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEC24D SYNPO2 KIAA1217 CCN2 EPHA5	3.57e-05	174	95	5	e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEC24D SYNPO2 KIAA1217 BIRC3 CCN2	3.67e-05	175	95	5	90e29945aa861082c94bb4f331161adc3a6ef899
ToppCell	AT1_cells-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	GGTLC3 GGTLC1 NCOA7 RGS11 PCYOX1	3.77e-05	176	95	5	4a30bb771297b30926fb98e2b5ec0dbdc46feac7
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEC24D SYNPO2 KIAA1217 BIRC3 CCN2	3.77e-05	176	95	5	e4b21fd6a5e0c5950f27c3e1868318e48330ae5e
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MPP2 ARNT2 EPHX3 PRDM6 FILIP1L	3.87e-05	177	95	5	4553ee8cd9c24db6511b09fe49ed11a89e7cde9e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEC24D SYNPO2 KIAA1217 BIRC3 FILIP1L	3.87e-05	177	95	5	bde307e67ad8e48a5ff4c0827015f4688f6b3e46
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEC24D SYNPO2 KIAA1217 BIRC3 FILIP1L	4.09e-05	179	95	5	7954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEC24D SYNPO2 KIAA1217 CCN2 EPHA5	4.31e-05	181	95	5	08f44323bf71b6004a921bbc969c954c75feeb66
ToppCell	droplet-Liver-nan-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPM2A ETS1 LAMA4 ESAM PCDH17	4.31e-05	181	95	5	fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCell	droplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPM2A ETS1 LAMA4 ESAM PCDH17	4.54e-05	183	95	5	709a486154b3157427deb3b8886b63ac39ea42dd
ToppCell	droplet-Liver-nan-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPM2A ETS1 LAMA4 ESAM PCDH17	4.54e-05	183	95	5	dc06f19f6f80f4c7f13f1f990c1fe0f91ba64ea7
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CILP HIPK2 LAMA4 CDH23 PRDM6	4.78e-05	185	95	5	1ac6a32cc56d5d819649bdd99518e2ead0eead4c
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMA4 ESAM LIX1L PCDH17 TMED4	4.91e-05	186	95	5	39e475a3c167b33daa63b0c1bfa32451c5f46635
ToppCell	Thalamus-Endothelial\|Thalamus / BrainAtlas - Mouse McCarroll V32	ANGPTL4 ETS1 LAMA4 ESAM CCN2	4.91e-05	186	95	5	dcc6e4417c4123d5ca6b96fa8ca4874626aaebdb
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMA4 ESAM LIX1L PCDH17 TMED4	4.91e-05	186	95	5	02418c50fdcca549bf73dedf6199ab4a27862a9b
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NR1I2 LAMA4 C3 ST3GAL2 FILIP1L	5.16e-05	188	95	5	aa516273cdde53c8c0295f06830972388f890c97
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCAF1 PDE6D ANK3 ARNT2 PRDM6	5.16e-05	188	95	5	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCAF1 PDE6D ANK3 ARNT2 PRDM6	5.16e-05	188	95	5	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCAF1 PDE6D ANK3 ARNT2 PRDM6	5.16e-05	188	95	5	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	368C-Epithelial_cells-Epithelial-I_(AT1)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	MTA3 PUDP GGTLC1 SLC35E1 TEP1	5.16e-05	188	95	5	c74771584b3ba9561a99a54bf55a9203ddf8eff8
ToppCell	368C-Epithelial_cells-Epithelial-I_(AT1)\|368C / Donor, Lineage, Cell class and subclass (all cells)	MTA3 PUDP GGTLC1 SLC35E1 TEP1	5.16e-05	188	95	5	9155b9a92496e75646778c025b02947e9e9ec73a
ToppCell	facs-MAT-Fat-3m\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEC24D ANGPTL4 MTREX PRDM6 PCYOX1	5.16e-05	188	95	5	7da9750255efbc5cf9aed7e3105a337fac63b9f0
ToppCell	Substantia_nigra-Endothelial\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SLC25A24 ETS1 LAMA4 CCN2 FILIP1L	5.29e-05	189	95	5	bef8234bd9c4d6e3cdef0791d8066b39ba56ebba
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SYNPO2 CILP CCN2 PRDM6 FILIP1L	5.29e-05	189	95	5	975e7aa3b862a8b07c2ab8426a14f5cc54998aca
ToppCell	facs-Lung-18m-Mesenchymal\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STBD1 ANGPTL4 LAMA4 C3 PRDM6	5.29e-05	189	95	5	bdf8db938aa0863c4fed6fa99dcffd63c8c20c31
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GGTLC1 ANGPTL4 BIRC3 NCOA7 PCYOX1	5.43e-05	190	95	5	8ceb327dc995f4b83b05d5d6630e1294f0cb49bd
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PPARGC1B ABCA4 LAMA4 ESAM CCN2	5.43e-05	190	95	5	06bfb62b94b0faf467ef93d5bc5d08924c770098
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SYNPO2 SLCO1C1 CILP PRDM6 FILIP1L	5.43e-05	190	95	5	73d94fbae92029745989a8712eed8b99fd84c193
ToppCell	droplet-Lung-18m-Mesenchymal\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STBD1 ANGPTL4 LAMA4 CCN2 PRDM6	5.43e-05	190	95	5	0b7200897b2c389632c9b1ee37e272b811555dbc
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STBD1 ANGPTL4 LAMA4 C3 PRDM6	5.56e-05	191	95	5	094c9d3270fc1e487ccf10fb4936af5f081f6009
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CILP ANGPTL4 LAMA4 CCN2 PRDM6	5.56e-05	191	95	5	cd497abed9e00e4e0becd9dbc036c6e7a60ae791
ToppCell	facs-Lung-24m-Mesenchymal\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STBD1 ANGPTL4 LAMA4 C3 PRDM6	5.56e-05	191	95	5	ba02cbdfda6a94374a6472eb88499059979af472
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIAA1217 ETS1 ESAM APOL2 PCDH17	5.56e-05	191	95	5	a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCell	droplet-Lung-nan-18m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STBD1 ANGPTL4 LAMA4 CCN2 PRDM6	5.70e-05	192	95	5	df56c3e3bb1aafc1126607f4426554c09c8c40cf
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANGPTL4 LAMA4 C3 CCN2 FILIP1L	5.70e-05	192	95	5	f88aba74d6e8c594c32fe2bc095b5da28b4b28e9
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANGPTL4 LAMA4 C3 CCN2 FILIP1L	5.70e-05	192	95	5	41a8326cd5bc19ad5041068501bab4c72399222e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNPO2 ETS1 LAMA4 ESAM FILIP1L	5.70e-05	192	95	5	09cb5b89a164ac7444774ccc8c90323c8ea2026b
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STBD1 ANGPTL4 LAMA4 CCN2 PRDM6	5.70e-05	192	95	5	ff4b728a55c2550c806c47e9ae3d057c35df8464
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-alveolar_fibroblast\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STBD1 ANGPTL4 LAMA4 CCN2 PRDM6	5.70e-05	192	95	5	2d3790bd80a7f214b37094121a2a86ff16362569
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SYNPO2 CCN2 PRDM6 FILIP1L EPHA5	5.84e-05	193	95	5	4aa976b596830b585e8d9c808d5072ed23d13a7c
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPP2 PPARGC1B SYNPO2 EPHX3 FILIP1L	5.84e-05	193	95	5	1043b28503bfaa0d5a82ec358bc86cbde73ea8f2
ToppCell	E15.5-Mesenchymal\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	STBD1 ANGPTL4 LIX1L PRDM6 EPHA5	5.84e-05	193	95	5	22a9f5b61f197757f72840b9cb849cdb20430e72
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 CILP LAMA4 CCN2 FILIP1L	5.84e-05	193	95	5	dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ANGPTL4 LAMA4 CDH23 CCN2 PRDM6	5.84e-05	193	95	5	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	ILEUM-inflamed-(8)_Smooth_muscle_cells\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SYNPO2 LAMA4 CCN2 PRDM6 FILIP1L	5.84e-05	193	95	5	084c88f08ce0ecd6c9f4334caed370eb2154f896
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPP2 PPARGC1B SYNPO2 EPHX3 FILIP1L	5.84e-05	193	95	5	0266a4fdf436d83ec1d9392abba8c6ec5166970a
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNPO2 ETS1 LAMA4 ESAM FILIP1L	5.84e-05	193	95	5	dd4bac8a93a5b9dcf7301f1d7d6e3eb6670f5c68
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SYNPO2 CCN2 PRDM6 FILIP1L EPHA5	5.84e-05	193	95	5	5578f7cb3ec68c9a38cc5304b618b81283024d5e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNPO2 ETS1 LAMA4 ESAM FILIP1L	5.84e-05	193	95	5	2ddf9b2770a0be9689e01d1a3d19e4a6d42c7a50
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 CILP LAMA4 CCN2 FILIP1L	5.84e-05	193	95	5	e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCell	metastatic_Brain-Fibroblasts-Pericytes\|metastatic_Brain / Location, Cell class and cell subclass	SYNPO2 SLCO1C1 LAMA4 ESAM FILIP1L	5.99e-05	194	95	5	d1889a3e22d5b88461c81ec3ea0e74bb9bf63e60
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNPO2 ETS1 LAMA4 ESAM FILIP1L	5.99e-05	194	95	5	78dcb9d48259afabe73b41c5508a73a8d62339a4
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 KIAA1217 LAMA4 MAP3K5 FILIP1L	5.99e-05	194	95	5	90efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 KIAA1217 LAMA4 MAP3K5 FILIP1L	5.99e-05	194	95	5	df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SYNPO2 STBD1 LAMA4 CCN2 PRDM6	5.99e-05	194	95	5	aaecde88bd54134a938e76cdf059c1c2653e4e77
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 LAMA4 CCN2 MAP3K5 FILIP1L	6.14e-05	195	95	5	d8ebb94f30d4a655d6b29dd6a3076be2403d2356
ToppCell	ASK428\|World / Donor, Lineage and Cell class of Lung cells from Dropseq	MID1IP1 C3 CCN2 DCXR PCYOX1	6.14e-05	195	95	5	41cbd7ea0bfab2db338b4ba0fc67cb3ae0d63d6d
ToppCell	normal_Lung-Epithelial_cells-AT2\|Epithelial_cells / Location, Cell class and cell subclass	MID1IP1 ESAM C3 HSD17B4 DCXR	6.14e-05	195	95	5	81e13fe337f1d0a83d0deb86a0df797d306cd24d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SEC24D SYNPO2 LAMA4 CCN2 FILIP1L	6.14e-05	195	95	5	cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCell	mild_COVID-19_(asymptomatic)-CD4+_Tcm\|World / disease group, cell group and cell class (v2)	MPP2 ANK3 ETS1 BIRC3 ARL14EP	6.14e-05	195	95	5	a72bb5b1b15dd1ab70ced5622d94499caff8bb6b
ToppCell	facs-Aorta-Heart-3m-Endothelial\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ETS1 HIPK2 ESAM MTREX PCDH17	6.14e-05	195	95	5	8493f2f60fc356af28b9c0e287d4cd8c8899c081
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SEC24D SYNPO2 LAMA4 CCN2 FILIP1L	6.14e-05	195	95	5	783bfa8110161cbd6def50ce849cae676c39c458
ToppCell	facs-Aorta-Heart-3m-Endothelial-aorta_endothelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIPK2 ESAM NCOA7 MTREX PCDH17	6.14e-05	195	95	5	3969b8d5fcec8ef1831531a781f7bbcebab5a4ba
ToppCell	Posterior_cortex-Endothelial\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SLC25A24 SYNPO2 ANGPTL4 ETS1 LAMA4	6.14e-05	195	95	5	988e3449691cc228cb55e5e30355136c97b12262
ToppCell	facs-Aorta-Heart-3m-Endothelial-aortic_endothelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ETS1 HIPK2 ESAM MTREX PCDH17	6.14e-05	195	95	5	5e5ca7bd94c9e924ed76f7ccac199be745d4c4eb
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNPO2 ETS1 LAMA4 ESAM FILIP1L	6.14e-05	195	95	5	d760d1423f9a8a373fe7b250ea9b1d67a0c0059f
Drug	troglitazone	MPP2 TKFC NR1I2 CHDH ANGPTL4 ARNT2 PKD1 HIPK2 LAMA4 BIRC3 C3 CYP4F2 CCN2 SCLY PLEC RSRC2 HSD17B4 HNF4A MAP3K5 FILIP1L	3.91e-07	1329	94	20	ctd:C057693
Drug	Cisapride [81098-60-4]; Down 200; 8.6uM; MCF7; HT_HG-U133A	MED15 EPM2A TLN1 C3 BAIAP2 TEP1 APOL2 FILIP1L	1.67e-06	198	94	8	3305_DN
Disease	CREST Syndrome	KIAA0319L CCN2	1.40e-04	6	91	2	C0206138
Disease	Scleroderma, Limited	KIAA0319L CCN2	1.40e-04	6	91	2	C0748540
Disease	aflatoxins-related hepatocellular carcinoma (biomarker_via_orthology)	GGTLC3 GGTLC1	1.96e-04	7	91	2	DOID:5022 (biomarker_via_orthology)
Disease	alcohol dependence (biomarker_via_orthology)	GGTLC3 GGTLC1	2.60e-04	8	91	2	DOID:0050741 (biomarker_via_orthology)
Disease	Prenatal Exposure Delayed Effects	CCN2 ATM	6.08e-04	12	91	2	C0033054
Disease	myeloid white cell count	SLC25A24 PDE6D CNTN5 PKD1 ETS1 CDH23 C3 QRICH1 HNF4A MAP3K5	6.26e-04	937	91	10	EFO_0007988
Disease	chromosome 22q11.2 deletion syndrome, distal (implicated_via_orthology)	MED15 TXNRD2	8.36e-04	14	91	2	DOID:0060413 (implicated_via_orthology)
Disease	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	BIRC3 ATM	1.10e-03	16	91	2	C0334634
Disease	response to cyclophosphamide	HIPK2 EPHA5	1.24e-03	17	91	2	GO_1902518
Disease	Age-related macular degeneration	ABCA4 C3	1.39e-03	18	91	2	cv:C0242383
Disease	Adenocarcinoma of prostate	SPOP ATM	1.72e-03	20	91	2	C0007112
Disease	schizophrenia (is_implicated_in)	MED15 ANK3 APOL2	1.83e-03	78	91	3	DOID:5419 (is_implicated_in)
Disease	Immunologic Deficiency Syndromes	C3 ATM	2.28e-03	23	91	2	C0021051
Disease	Fatty Liver	NR1I2 ANGPTL4 BIRC3	2.58e-03	88	91	3	C0015695
Disease	Steatohepatitis	NR1I2 ANGPTL4 BIRC3	2.58e-03	88	91	3	C2711227
Disease	Depressive Symptoms	AP2B1 TXNRD2	2.91e-03	26	91	2	C0086132
Disease	cardiovascular disease	MPP2 PLB1 CHDH HIPK2 PRDM6 RYK	2.94e-03	457	91	6	EFO_0000319

Protein segments in the cluster

Peptide	Gene	Start	Entry
VFMAVVMGQGQRVAE	ADCK2	511	Q7Z695
VEGPAQAMSRGTMIV	APOL2	261	Q9BQE5
QATTMLIQPMAAEAA	ANGPTL4	391	Q9BY76
NVPQVSSMQMGAVDL	AP2B1	641	P63010
TQMNMIRDTLGNPTV	ABCA4	446	P78363
MMDPCSVGVQLRTTN	ARL14EP	1	Q8N8R7
PRQSGLKNTSVMMVD	EPHA5	416	P54756
GEQNMIGMTPTVIAV	C3	1011	P01024
SEDAIMMNTPVINAA	BIRC3	371	Q13489
NTGSVMVKSPMNREL	CDH23	2236	Q9H251
RVVDASIMPSMVSGN	CHDH	541	Q8NE62
RLQVTSSPVCMDMNG	ARNT2	316	Q9HBZ2
SPQSRVEMVNGVLMI	CNTN5	431	O94779
ERNAMNVMNVVSSPS	PCDH17	776	O14917
SVQPISREQMGQMLT	QRICH1	741	Q2TAL8
VVSMQDPDQGVKMRS	RGS11	26	O94810
EMTQTMDKGFPQRVV	MMP27	401	Q9H306
MSTEGRVQMLPQAVC	EPM2A	236	O95278
QPSAASMAAVAQRSM	HIPK2	621	Q9H2X6
SMAAVAQRSMPLQTG	HIPK2	626	Q9H2X6
FIGAVNNMDQTVMVP	MID1IP1	21	Q9NPA3
QRIQPQMDMVEKESG	FN3KRP	171	Q9HA64
VEAALAAGMQVVMVP	PUDP	181	Q08623
MQGVRTPTLQLSAMQ	KIAA0319L	551	Q8IZA0
QMMIVASPTENGQVL	CARF	101	Q8N187
EHMGTNVIVANTMPT	HNF4A	396	P41235
IKQEVVTPDNMCMGR	ETS1	226	P14921
MIAPVMRVNYGQSTD	PCYOX1	216	Q9UHG3
VYMTDITPQGVAMRA	PDZK1P1	36	A8MUH7
QMMPASVLTGNVIIE	PDE6D	116	O43924
AVNPTVVMTSMGQAT	DCXR	176	Q7Z4W1
PTIMVGQDGQVRMVV	GGTLC1	111	Q9BX51
MNPSQALKVRGMVVE	INTS2	256	Q9H0H0
QTAQAAQMVAPGVQM	MED15	371	Q96RN5
AQMVAPGVQMITEAL	MED15	376	Q96RN5
METMRAQRLQPGVGT	LIX1L	1	Q8IVB5
PVNSTMSIGQARKMV	GNG3	6	P63215
IEQPVQQSDMTMVGS	KIAA1549L	486	Q6ZVL6
MPVAATNSETAMQQV	MPP2	1	Q14168
QPLGVQGLTEEQRMM	NR1I2	136	O75469
PTIMVGQDGQVRMVV	GGTLC3	111	B5MD39
NVPSTVMEAMCRQDA	PRDM6	386	Q9NQX0
VNTINPGARFMTTAM	UPF1	931	Q92900
IMRASQDNPQDGIMV	ATM	1631	Q13315
QARSMSGHPEAAQMV	CKAP5	1466	Q14008
QGMSPITMATFARAQ	FILIP1L	971	Q4L180
MTAASMGPVRVAFVV	CCN2	1	P29279
TIAPNAGSRMTQTVM	HSD17B4	191	P51659
TMISNTANSQMGVRP	ANK3	3761	Q12955
MVNPTEEGMRVLTQL	CYP4F2	66	P78329
SRMGAVPVMVPAQSQ	ESAM	371	Q96AP7
ERMVVVSGAPMSVYQ	EPHX3	191	Q9H6B9
MLEMRQAGIVPNTIT	DENND4B	836	O75064
VANESQKTPRDVVMM	EXOC1	716	Q9NV70
SNVSAAVMVLMAPRG	DNAH9	3186	Q9NYC9
LAMDMPQVNISVQGE	RYK	131	P34925
MNRMQGLQVSTVPAV	PKD1	1016	P98161
ANRTTMEVQQATAPM	LAMA4	741	Q16363
ALDIMIPMVQSEGQV	MAP3K5	371	Q99683
HVSRQAMQGMPVRNT	MTA3	441	Q9BTC8
GTQVTPQIAMAAQMA	RSRC2	286	Q7L4I2
SFPVMVNDMGQVLIA	TCAF1	36	Q9Y4C2
VGGVMIVTPNNIMFD	NCOA7	236	Q8NI08
GAPVSQEDMQAMVQL	PPARGC1B	276	Q86YN6
GMMVRHAQSSPVVIQ	KIAA1217	881	Q5T5P2
IMRMNQAPTVGFEQD	ST3GAL2	176	Q16842
SGMNPIQTMTEVRAR	CCT5	466	P48643
ATETFAMGVNMPART	SKIV2L	661	Q15477
AMGVNMPARTVVFDS	SKIV2L	666	Q15477
TERPQQVCMGVMTVL	PLB1	96	Q6P1J6
RNPVTSTNVLGMMTA	SLC35E1	311	Q96K37
SNLAQPQMMVVTDVG	SEC24D	501	O94855
IPMTGMINGNQAIRE	BCL2L15	136	Q5TBC7
FVGRMSAQESTPIMN	BAIAP2	286	Q9UQB8
MVMNPETKARRAGQS	CILP	311	O75339
PDGSRMMAVAALVVN	NLN	461	Q9BYT8
VTIMLANNETGIVMP	SCLY	191	Q96I15
MSVLNMVVRRDPGNT	TSR1	591	Q2NL82
SGTSETANIQRMVPM	SYNPO2	571	Q9UMS6
QQYPSGRSVTEMEVM	TEP1	996	Q99973
AMGINMPARTVLFTN	MTREX	486	P42285
MERVAVMPAGSQQVS	STBD1	251	O95210
NQRTHEQMGPSIEAM	PROM2	176	Q8N271
PMSHQGTENIVAVMI	RNF148	141	Q8N7C7
GNVVKTMQFEPSTMV	TLN1	11	Q9Y490
SGQNTMNMVKVPECR	SPOP	171	O43791
QTPQGENAKIMEMAR	SLCO1C1	326	Q9NYB5
MAAQRGMPSSAVRVL	SPAG16	1	Q8N0X2
PGVTNLQVMRAMASL	PLEC	41	Q15149
MAQTGVPFGEVSMVR	SMUG1	91	Q53HV7
IPDETMVIGNYRTQM	TMED4	46	Q7Z7H5
MRPDQMYGNVVVTSI	WFIKKN1	231	Q96NZ8
IPLRGFDQQMSSMVI	TXNRD2	251	Q9NNW7
VTEMGQEVTMRCQPI	TRBV12-5	31	A0A1B0GX78
LPGTVMAQRENSVMS	SOHLH2	286	Q9NX45
VQPGSSVVMMVNNLG	TKFC	256	Q3LXA3
TRMQAQAMLEGSPQL	SLC25A24	411	Q6NUK1
VMRLTNTNGEVVPMS	TRPV5	441	Q9NQA5
GDPIEVVGQRQSSMM	UBE3C	521	Q15386
VVGQRQSSMMPFTLE	UBE3C	526	Q15386