Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainCadherin_tail

PCDHGB4 PCDHGC4 PCDHGB5

4.88e-0537363PF15974
DomainCadherin_CBD

PCDHGB4 PCDHGC4 PCDHGB5

4.88e-0537363IPR031904
DomainCadherin_N

PCDHGB4 PCDHGC4 PCDHGB5

2.65e-0465363IPR013164
DomainCadherin_2

PCDHGB4 PCDHGC4 PCDHGB5

2.65e-0465363PF08266
DomainPIN_domain-like

ERCC5 FAM120A

3.24e-0414362IPR029060
DomainCadherin_CS

PCDHGB4 PCDHGC4 PCDHGB5

1.20e-03109363IPR020894
DomainCadherin

PCDHGB4 PCDHGC4 PCDHGB5

1.33e-03113363PF00028
DomainCADHERIN_1

PCDHGB4 PCDHGC4 PCDHGB5

1.33e-03113363PS00232
DomainCADHERIN_2

PCDHGB4 PCDHGC4 PCDHGB5

1.37e-03114363PS50268
Domain-

PCDHGB4 PCDHGC4 PCDHGB5

1.37e-031143632.60.40.60
DomainCA

PCDHGB4 PCDHGC4 PCDHGB5

1.40e-03115363SM00112
DomainCadherin-like

PCDHGB4 PCDHGC4 PCDHGB5

1.44e-03116363IPR015919
DomainCadherin

PCDHGB4 PCDHGC4 PCDHGB5

1.51e-03118363IPR002126
DomainCadherin_C_2

PCDHGB4 PCDHGB5

2.96e-0342362PF16492
DomainCadherin_C

PCDHGB4 PCDHGB5

2.96e-0342362IPR032455
Pubmed

Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study.

CHD1 GPC6

2.18e-05736222044751
Pubmed

Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.

PCDHGB4 PCDHGC4 PCDHGB5

4.87e-056836311230163
Pubmed

A striking organization of a large family of human neural cadherin-like cell adhesion genes.

PCDHGB4 PCDHGC4 PCDHGB5

5.78e-057236310380929
Pubmed

Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.

PCDHGB4 PCDHGC4 PCDHGB5

6.28e-057436310817752
Pubmed

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.

PCDHGB4 PCDHGC4 PCDHGB5

7.07e-057736310835267
Pubmed

Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.

PCDHGB4 PCDHGC4 PCDHGB5

7.92e-058036310716726
Pubmed

Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.

PCDHGB4 PCDHGB5

1.08e-041536223515096
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

CHD1 FAM120A GPC6 YTHDC1

1.30e-0425136428077445
Pubmed

Identification of a Pax6-dependent epidermal growth factor family signaling source at the lateral edge of the embryonic cerebral cortex.

NRG2 TMEFF2

1.76e-041936212878679
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

USP34 CHD1 ERCC5 CCDC6 RCC2 CFAP97

3.14e-0491036636736316
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

CCSAP CCDC6 GPC6 YTHDC1 SIPA1L3 SH3KBP1

3.37e-0492236627609421
Pubmed

Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China.

ERCC5 POLQ

3.87e-042836219661089
Pubmed

Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.

PCDHGB4 PCDHGB5

3.87e-042836215347688
Pubmed

Functional significance of isoform diversification in the protocadherin gamma gene cluster.

PCDHGB4 PCDHGB5

5.72e-043436222884324
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DISP2 TNRC6C SPEG PDZD2

8.10e-0440736412693553
Pubmed

Characterization of the DOT1L network: implications of diverse roles for DOT1L.

CHD1 EAF1

8.33e-044136220431927
Pubmed

14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation.

SPEG SIPA1L3

8.74e-044236223444366
Pubmed

A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-gamma gene cluster.

PCDHGB4 PCDHGB5

9.59e-044436219029045
CytobandEnsembl 112 genes in cytogenetic band chr5q31

PCDHGB4 CXXC5 NRG2 PCDHGC4 PCDHGB5

3.56e-06298365chr5q31
Cytoband5q31

PCDHGB4 PCDHGC4 PCDHGB5

1.03e-041153635q31
GeneFamilyClustered protocadherins

PCDHGB4 PCDHGC4 PCDHGB5

3.94e-056419320
GeneFamilyPDZ domain containing

SIPA1L3 PDZD2

1.09e-021521921220
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

NRG2 SPEG

1.22e-02161192593
GeneFamilyAnkyrin repeat domain containing

SOWAHC ACAP3

2.63e-02242192403
CoexpressionAtlasDevelopingKidney_e15.5_Cap mesenchyme_emap-27738_top-relative-expression-ranked_1000

CXXC5 SOX11 NOL4L HEATR6 EAF1 GPC6 GLDC SPEG

3.84e-05779368gudmap_developingKidney_e15.5_Cap mesenchyme_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_1000

SOX11 DISP2 CHD1 NOL4L HEATR6 GPC6 SIPA1L3 TMEFF2

5.43e-05818368gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma|TCGA-Endometrium / Sample_Type by Project: Shred V9

CXXC5 SOX11 NOL4L GLDC

9.15e-0616436408c725548e751f815b4df778607270498204b353
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CXXC5 SOX11 ACAP3 TMEFF2

1.53e-05187364dfc2b95d70daf533bc0cc4ce78af9f65dd75a25b
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CXXC5 SOX11 ACAP3 TMEFF2

1.67e-05191364a53616c84178eb6c29b48662358765b082df3f97
ToppCellBronchus_Control_(B.)-Epithelial-TX-AT2-2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

SOX11 PCDHGC4 GLDC PDZD2

1.77e-051943645bfc26668fa8f109f2ebc0d5fd98ab5bd219e62c
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CXXC5 SOX11 ACAP3 TMEFF2

1.88e-051973641378bf90a4b80b8166ef352c282ce51b114ba693
Diseasechildhood trauma measurement, alcohol consumption measurement

PCDHGB4 PCDHGC4 PCDHGB5

8.27e-0571353EFO_0007878, EFO_0007979
Diseasemental development measurement

PCDHGB4 PCDHGB5

4.03e-0425352EFO_0008230
Diseasemean platelet volume

PCDHGB4 NOL4L PCDHGC4 PCDHGB5 RCC2 SH3KBP1

1.16e-031020356EFO_0004584
DiseaseMemory Disorders

CHD1 HTR6

1.20e-0343352C0025261
DiseaseMemory Loss

CHD1 HTR6

1.20e-0343352C0751295
DiseaseAge-Related Memory Disorders

CHD1 HTR6

1.20e-0343352C0751292
DiseaseMemory Disorder, Spatial

CHD1 HTR6

1.20e-0343352C0751294
DiseaseMemory Disorder, Semantic

CHD1 HTR6

1.20e-0343352C0751293
DiseaseMemory impairment

CHD1 HTR6

1.25e-0344352C0233794
Diseaseepithelial cell adhesion molecule measurement

USP34 ERCC5

1.68e-0351352EFO_0010574
Diseasemultisite chronic pain

SOX11 FAM120A

5.70e-0395352EFO_0010100
DiseaseHIV-1 infection

FAM174B TMEFF2

6.05e-0398352EFO_0000180
Diseasealpha fetoprotein measurement

USP34 POLQ

6.29e-03100352EFO_0010583
Diseaseprostate cancer (is_implicated_in)

CHD1 TMEFF2

8.52e-03117352DOID:10283 (is_implicated_in)
Diseasecreatinine measurement, glomerular filtration rate

PCDHGB4 SIPA1L3

8.52e-03117352EFO_0004518, EFO_0005208
Diseasechronic obstructive pulmonary disease

SOX11 NOL4L SPEG PDZD2

8.65e-03688354EFO_0000341
Diseaseage at first birth measurement

SOX11 NOL4L

8.94e-03120352EFO_0009101

Protein segments in the cluster

PeptideGeneStartEntry
AGGSGSGSSSSEADR

USHBP1

236

Q8N6Y0
PDSDSDSDAGSGGSS

HTR6

376

P50406
SSGSGTDCLDAGSDS

CFAP97

181

Q9P2B7
STSSSSDNDEGSGGA

C9orf129

106

Q5T035
AAGGSGSSSSNSSGD

FAM174B

61

Q3ZCQ3
LSSDSGLGGSSDGSS

ACAP3

606

Q96P50
GSSEDSASSESSGAG

CCSAP

56

Q6IQ19
SESDTDGAGGNSSSS

CCDC6

6

Q16204
FSGGESDTGSSAESS

C2CD4C

211

Q8TF44
DDDSGSASGSGSGSS

CHD1

21

O14646
DGSSSQSGSSDSDSG

CHD1

41

O14646
QSGSSDSDSGSESGS

CHD1

46

O14646
MDGDSSSSSGGSGPA

DISP2

1

A7MBM2
SSGSDDDSSSSGGED

EAF1

201

Q96JC9
RCSSSSGGGSSGDED

RCC2

41

Q9P258
SASEAADGSSTLGGG

PCDHGB4

846

Q9UN71
KGFGSDSSSSGDSSA

MUC19

356

Q7Z5P9
ASAGGSDEGSSSSLG

PDZD2

701

O15018
SSGSGGGSASASDDD

NRG2

766

O14511
EDSCSGSDAGSAAGS

HEATR6

666

Q6AI08
SSTSSSSDNDEGSGG

FAM120A

456

Q9NZB2
SASEAADGSSTLGGG

PCDHGB5

846

Q9Y5G0
SASEAADGSSTLGGG

PCDHGC4

861

Q9Y5F7
DDDSSSESGSGNGSS

NOL4L

36

Q96MY1
GGSQDAGGSSSSSTN

CXXC5

6

Q7LFL8
QDTSDESSGSGSGSG

GPC6

486

Q9Y625
GSDSFSGSGGDSSAS

POLQ

16

O75417
SSGSSSGSSGEDADD

SOX11

346

P35716
SGTTASEGSSDGSGN

TNRC6C

391

Q9HCJ0
SEGSCATDAGSGSGD

TMEFF2

131

Q9UIK5
GGATTSSSSDSDDDG

ERCC5

1141

P28715
SESDGGDSSSTKSEG

SH3KBP1

181

Q96B97
DGTSSGDSSSGGLTS

SIPA1L3

1196

O60292
GRGGGDSDSASVASS

SOWAHC

236

Q53LP3
DDGSSSSGGSSVAGS

SUN2

16

Q9UH99
SGSSEDSGGASGRST

SPEG

2471

Q15772
TDGSVRSGSGTDGSD

YTHDC1

281

Q96MU7
SSGPGSSSGHSDGSS

USP34

576

Q70CQ2
DSSSGGGDSAAAGAS

GLDC

36

P23378