Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Hud_Sxl_RNA	CELF1 CELF2	1.35e-04	10	33	2	IPR002343
Domain	UIM	EPN1 HGS	4.55e-04	18	33	2	PF02809
Domain	UIM	EPN1 HGS	6.23e-04	21	33	2	SM00726
Domain	UIM	EPN1 HGS	8.15e-04	24	33	2	PS50330
Domain	UIM_dom	EPN1 HGS	8.85e-04	25	33	2	IPR003903
Domain	-	EPN1 HGS	9.58e-04	26	33	2	1.25.40.90
Domain	Ion_trans_dom	CACNA1E SCN3A ITPR2	1.06e-03	114	33	3	IPR005821
Domain	Ion_trans	CACNA1E SCN3A ITPR2	1.06e-03	114	33	3	PF00520
Domain	ENTH_VHS	EPN1 HGS	1.19e-03	29	33	2	IPR008942
Domain	EF-hand_8	SLC25A25 MICU1	1.64e-03	34	33	2	PF13833
Domain	Channel_four-helix_dom	CACNA1E SCN3A	4.55e-03	57	33	2	IPR027359
Domain	-	CACNA1E SCN3A	4.55e-03	57	33	2	1.20.120.350
Domain	RRM_1	CELF1 CELF2 PUF60	5.81e-03	208	33	3	PF00076
Domain	RRM	CELF1 CELF2 PUF60	6.53e-03	217	33	3	SM00360
Domain	RRM_dom	CELF1 CELF2 PUF60	7.39e-03	227	33	3	IPR000504
Domain	RRM	CELF1 CELF2 PUF60	7.66e-03	230	33	3	PS50102
Domain	EF_HAND_2	CACNA1E SLC25A25 MICU1	7.75e-03	231	33	3	PS50222
Domain	EF_hand_dom	CACNA1E SLC25A25 MICU1	7.84e-03	232	33	3	IPR002048
Domain	-	CELF1 CELF2 PUF60	9.00e-03	244	33	3	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	CELF1 CELF2 PUF60	1.05e-02	258	33	3	IPR012677
Domain	EF-hand-dom_pair	SLC25A25 SCN3A MICU1	1.39e-02	287	33	3	IPR011992
Pubmed	Diversity and conservation of CELF1 and CELF2 RNA and protein expression patterns during embryonic development.	CELF1 CELF2	9.84e-07	2	35	2	23468433
Pubmed	Isolation and expression of Napor/CUG-BP2 in embryo development.	CELF1 CELF2	9.84e-07	2	35	2	12763013
Pubmed	Expression of a dominant negative CELF protein in vivo leads to altered muscle organization, fiber size, and subtype.	CELF1 CELF2	9.84e-07	2	35	2	21541285
Pubmed	Dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development.	CELF1 CELF2	9.82e-06	5	35	2	15830352
Pubmed	The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing.	CELF1 CELF2	1.47e-05	6	35	2	11158314
Pubmed	Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability.	EPN1 HGS	1.47e-05	6	35	2	19478092
Pubmed	MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1.	CELF1 CELF2	1.47e-05	6	35	2	19720736
Pubmed	A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator.	CELF1 CELF2	1.47e-05	6	35	2	10893231
Pubmed	miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification.	CELF1 CELF2	2.06e-05	7	35	2	27512039
Pubmed	Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators.	CELF1 CELF2	3.53e-05	9	35	2	28763438
Pubmed	Regulation of ubiquitin-binding proteins by monoubiquitination.	EPN1 HGS	4.40e-05	10	35	2	16429130
Pubmed	Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development.	KRT8 ITPR2	5.38e-05	11	35	2	27514653
Pubmed	Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.	HLA-DQA2 IL21	5.38e-05	11	35	2	20596022
Pubmed	The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein.	KRT8 EPN1 IL21	6.24e-05	76	35	3	23940030
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	CACNA1E LRRC7 SLC25A25 PUF60 ITPR2	6.75e-05	430	35	5	32581705
Pubmed	Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.	EPN1 HGS	7.62e-05	13	35	2	12218189
Pubmed	Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions.	CELF1 CELF2	8.89e-05	14	35	2	28826478
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	LRRC7 BMPR2 PLEKHA7 PUF60 SIPA1L3	2.41e-04	565	35	5	25468996
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	SHPRH GPRASP1 KRT8 CELF1 PLEKHA7 MICU1	4.54e-04	1005	35	6	19615732
Pubmed	Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.	TLR1 IL21	4.79e-04	32	35	2	23817571
Pubmed	BMPR2 is required for postimplantation uterine function and pregnancy maintenance.	KRT8 BMPR2	5.41e-04	34	35	2	23676498
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	KRT8 SLC12A7 PLEKHA7 SIPA1L3 HGS ITPR2	5.70e-04	1049	35	6	27880917
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1E ITPR2	6.76e-04	38	35	2	30786075
Pubmed	Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.	KRT8 HGS	7.12e-04	39	35	2	22458338
Pubmed	14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation.	PLEKHA7 SIPA1L3	8.26e-04	42	35	2	23444366
Pubmed	Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.	KRT8 BMPR2 CELF1 TMEM255A	9.06e-04	432	35	4	7671812
GeneFamily	RNA binding motif containing	CELF1 CELF2 PUF60	4.25e-03	213	28	3	725
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF717 ZNF157 ZNF501 ZNF846 SCAPER	4.48e-03	718	28	5	28
GeneFamily	EF-hand domain containing	CACNA1E SLC25A25 MICU1	4.59e-03	219	28	3	863
Coexpression	GSE18893_TCONV_VS_TREG_24H_CULTURE_DN	BMPR2 IFI44L INPP1 TESK2 TLR1	6.63e-06	200	35	5	M7289
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_1000	SHPRH MKX ZNF717 SETDB1 KRT8 CELF1 TMEM255A SCN3A	2.48e-05	806	33	8	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_1000
CoexpressionAtlas	FacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_2500_k-means-cluster#4	MKX BMPR2 ZNF157 INPP1 TESK2 SCAPER MICU1	1.09e-04	731	33	7	Facebase_RNAseq_e8.5_Paraxial Mesoderm_2500_K4
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#5	MKX BMPR2 ZNF157 INPP1 TESK2 SCAPER MICU1	1.12e-04	734	33	7	Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_2500_K5
CoexpressionAtlas	dev gonad_e13.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000	GPRASP1 KRT8 ZNF157 CELF2 SLC12A7 ZNF846 ITPR2	1.96e-04	804	33	7	gudmap_dev gonad_e13.5_F_SupCellPrec_Sry_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_1000	SHPRH MKX SETDB1 KRT8 CELF1 SIPA1L3 SCN3A	1.99e-04	806	33	7	gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#3	MKX BMPR2 ZNF157 TESK2 ITPR2 SCAPER MICU1	2.46e-04	834	33	7	Facebase_RNAseq_e10.5_Mandibular Arch_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#1	MKX BMPR2 ZNF157 INPP1 TESK2 MICU1	2.60e-04	589	33	6	Facebase_RNAseq_e9.5_Maxillary Arch_2500_K1
Disease	meningitis	CACNA1E SCAPER	6.23e-05	11	32	2	MONDO_0021108
Disease	amblyopia	CACNA1E HLA-DQA2	2.60e-04	22	32	2	MONDO_0001020
Disease	asthma (is_implicated_in)	HLA-DQA2 TLR1 IL21	6.54e-04	157	32	3	DOID:2841 (is_implicated_in)
Disease	epilepsy (implicated_via_orthology)	CACNA1E SLC12A7 SCN3A	7.30e-04	163	32	3	DOID:1826 (implicated_via_orthology)
Disease	Intellectual Disability	CACNA1E PUF60 SCN3A SCAPER	1.34e-03	447	32	4	C3714756
Disease	allergic disease, age at onset	TLR1 IL21	2.70e-03	71	32	2	EFO_0004847, MONDO_0005271
Disease	serum gamma-glutamyl transferase measurement	KRT8 CELF1 CELF2 SIPA1L3 MICU1	2.83e-03	914	32	5	EFO_0004532
Disease	juvenile idiopathic arthritis	INPP1 IL21	2.93e-03	74	32	2	EFO_0002609
Disease	liver cirrhosis (is_marker_for)	KRT8 IL21	3.58e-03	82	32	2	DOID:5082 (is_marker_for)
Disease	susceptibility to plantar warts measurement	CELF2 HLA-DQA2	4.30e-03	90	32	2	EFO_0008406
Disease	reticulocyte measurement	BMPR2 CELF1 SLC12A7 PLEKHA7 TESK2	5.18e-03	1053	32	5	EFO_0010700
Disease	immature platelet fraction	SLC12A7 TESK2	6.80e-03	114	32	2	EFO_0009187

Protein segments in the cluster

Peptide	Gene	Start	Entry
TRAMAQNAIKAMHQS	CELF2	181	O95319
RTSQLRKHMQMSSQE	CACNA1E	781	Q15878
QTAHSMTNRFNAMLK	CCDC7	266	Q96M83
TTRAMAQTAIKAMHQ	CELF1	156	Q92879
TLFMKSHSNMVQRAA	ITPR2	1561	Q14571
RLESGMQNMSIHTKT	KRT8	401	P05787
VGKHTLEFMMRQSNS	HLA-DQA2	91	P01906
MGTNMHSLQLTISRR	INPP1	226	P49441
AMHAGRSMTLNLQTK	LRRC7	1306	Q96NW7
RSMTSQSRVMNVHKM	IFI44L	376	Q53G44
VQSIIRSQTSMGMRH	MICU1	246	Q9BPX6
ATNTTMMGKTRQRNH	MKX	236	Q8IYA7
MMGKTRQRNHSGSFS	MKX	241	Q8IYA7
KSSSQGQDRHMIRMR	IL21	26	Q9HBE4
MSTAMQNERNLSHNR	BMPR2	521	Q13873
MRTRGQTDSKNNSKH	CFAP97D2	81	A0A1B0GU71
MSTSSLRRQMKNIVH	EPN1	1	Q9Y6I3
SMKPDQSNVRRMHTA	SLC12A7	1006	Q9Y666
MMASFQRSNSHDKVR	SCAPER	1	Q9BY12
GNRVKDSNRSMHMAN	GPRASP1	216	Q5JY77
SISGSSARHMVMQKL	PUF60	441	Q9UHX1
MHQSLTQQRSSDMSL	TMEM255A	1	Q5JRV8
HMSKQDRNQRPSSMV	PLEKHA7	106	Q6IQ23
TKMAHSMRSIQNGQP	SIPA1L3	111	O60292
RMQAMLKTAERSHTN	SHPRH	1641	Q149N8
RNSNVSQASMSSRMV	SCN3A	621	Q9NY46
SMHQSRRLMASAQSN	SETDB1	1081	Q15047
MNIKNFTVSGTRMVH	TLR1	326	Q15399
RMAVQHMKTLRGATN	ARNTL	116	O00327
KVLMQVHASRSNNMG	SLC25A25	211	Q6KCM7
RSVTVNHMSDNRSMS	UHRF1BP1L	921	A0JNW5
MKMTLNNHQRTHTGE	ZNF157	341	P51786
RSTNLNMHMRTHTGE	ZNF846	461	Q147U1
VTTFVNRMKSNHMRG	HGS	416	O14964
NRMKSNHMRGRSITN	HGS	421	O14964
QQGNMHKNMRVLSRT	nan	301	A8MX80
QRTHTGKNRMDVMNV	ZNF717	666	Q9BY31
RHRASGQVMALKMNT	TESK2	76	Q96S53
GVHSMNDFRSKMQSI	TMEM242	106	Q9NWH2
MNSSQISLRMKHGRV	ZNF501	1	Q96CX3