Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	TRPM6 CACNA1A SLC22A18 SLC9C1 SLC16A6 SLC17A3 MLC1 KCNJ8 ABCB11 SV2C SLC45A2 KCNMB3 SLC45A1 ABCA10 TMEM38B MFSD12 SLC52A3	9.58e-06	1180	86	17	GO:0022857
GeneOntologyMolecularFunction	transporter activity	TRPM6 CACNA1A SLC22A18 SLC9C1 SLC16A6 SLC17A3 MLC1 KCNJ8 ABCB11 SV2C SLC45A2 KCNMB3 SLC45A1 ABCA10 TMEM38B MFSD12 SLC52A3	3.00e-05	1289	86	17	GO:0005215
GeneOntologyMolecularFunction	hexose:proton symporter activity	SLC45A2 SLC45A1	5.48e-05	3	86	2	GO:0009679
GeneOntologyMolecularFunction	D-glucose:proton symporter activity	SLC45A2 SLC45A1	5.48e-05	3	86	2	GO:0005356
GeneOntologyMolecularFunction	sucrose:monoatomic cation symporter activity	SLC45A2 SLC45A1	1.09e-04	4	86	2	GO:0009669
GeneOntologyMolecularFunction	sucrose transmembrane transporter activity	SLC45A2 SLC45A1	1.09e-04	4	86	2	GO:0008515
GeneOntologyMolecularFunction	sucrose:proton symporter activity	SLC45A2 SLC45A1	1.09e-04	4	86	2	GO:0008506
GeneOntologyMolecularFunction	oligosaccharide transmembrane transporter activity	SLC45A2 SLC45A1	1.09e-04	4	86	2	GO:0015157
GeneOntologyMolecularFunction	disaccharide transmembrane transporter activity	SLC45A2 SLC45A1	1.09e-04	4	86	2	GO:0015154
GeneOntologyMolecularFunction	alkylglycerophosphoethanolamine phosphodiesterase activity	GNA11 GNAQ	1.82e-04	5	86	2	GO:0047391
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC22A18 SLC9C1 SLC17A3 KCNJ8 ABCB11 SLC45A2 SLC45A1 ABCA10 MFSD12	2.12e-04	477	86	9	GO:0022804
GeneOntologyMolecularFunction	xenobiotic transmembrane transporter activity	SLC22A18 SLC17A3 ABCB11	4.19e-04	34	86	3	GO:0042910
GeneOntologyMolecularFunction	symporter activity	SLC22A18 SLC17A3 SLC45A2 SLC45A1 MFSD12	4.78e-04	150	86	5	GO:0015293
GeneOntologyMolecularFunction	carbohydrate:proton symporter activity	SLC45A2 SLC45A1	5.05e-04	8	86	2	GO:0005351
GeneOntologyMolecularFunction	carbohydrate transmembrane transporter activity	ABCB11 SLC45A2 SLC45A1	7.84e-04	42	86	3	GO:0015144
GeneOntologyMolecularFunction	monoatomic ion channel activity	TRPM6 CACNA1A SLC9C1 SLC17A3 MLC1 KCNJ8 KCNMB3 TMEM38B	8.12e-04	459	86	8	GO:0005216
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	TRPM6 CACNA1A SLC9C1 SLC17A3 KCNJ8 SLC45A2 KCNMB3 SLC45A1 TMEM38B	1.50e-03	627	86	9	GO:0022890
GeneOntologyMolecularFunction	neuropeptide receptor activity	NPY6R MCHR1 GPR151	1.55e-03	53	86	3	GO:0008188
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC22A18 SLC16A6 SLC17A3 ABCB11 MFSD12 SLC52A3	1.67e-03	293	86	6	GO:0008514
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC22A18 SLC9C1 SLC17A3 SLC45A2 SLC45A1 MFSD12	1.76e-03	296	86	6	GO:0015291
GeneOntologyMolecularFunction	channel activity	TRPM6 CACNA1A SLC9C1 SLC17A3 MLC1 KCNJ8 KCNMB3 TMEM38B	1.91e-03	525	86	8	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	TRPM6 CACNA1A SLC9C1 SLC17A3 MLC1 KCNJ8 KCNMB3 TMEM38B	1.93e-03	526	86	8	GO:0022803
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	TRPM6 CACNA1A SLC9C1 SLC17A3 MLC1 KCNJ8 SLC45A2 KCNMB3 SLC45A1 TMEM38B	2.14e-03	793	86	10	GO:0015075
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	TRPM6 CACNA1A SLC9C1 SLC17A3 KCNJ8 SLC45A2 KCNMB3 SLC45A1 TMEM38B	2.22e-03	664	86	9	GO:0008324
GeneOntologyMolecularFunction	carbohydrate:monoatomic cation symporter activity	SLC45A2 SLC45A1	2.39e-03	17	86	2	GO:0005402
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	TRPM6 CACNA1A SLC9C1 SLC17A3 KCNJ8 KCNMB3 TMEM38B	3.92e-03	465	86	7	GO:0046873
GeneOntologyMolecularFunction	glucosyltransferase activity	UGT8 ALG8	4.00e-03	22	86	2	GO:0046527
GeneOntologyMolecularFunction	G-protein beta/gamma-subunit complex binding	GNA11 GNAQ	5.16e-03	25	86	2	GO:0031683
GeneOntologyMolecularFunction	D-glucose transmembrane transporter activity	SLC45A2 SLC45A1	5.16e-03	25	86	2	GO:0055056
GeneOntologyMolecularFunction	hexose transmembrane transporter activity	SLC45A2 SLC45A1	5.16e-03	25	86	2	GO:0015149
GeneOntologyMolecularFunction	solute:proton symporter activity	SLC45A2 SLC45A1	5.16e-03	25	86	2	GO:0015295
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	TRPM6 CACNA1A SLC9C1 SLC17A3 KCNJ8 SLC45A2 KCNMB3 SLC45A1 TMEM38B	5.29e-03	758	86	9	GO:0015318
Domain	MFS_1	SLC22A18 SLC16A6 SLC17A3 SV2C SLC45A2 SLC45A1 MFSD12	4.17e-08	77	81	7	PF07690
Domain	MFS	SLC22A18 SLC16A6 SLC17A3 SV2C SLC45A2 SLC45A1 MFSD12	4.17e-08	77	81	7	IPR011701
Domain	XTBD	CDKN2AIP CDKN2AIPNL	1.86e-05	2	81	2	PF11952
Domain	XTBD	CDKN2AIP CDKN2AIPNL	1.86e-05	2	81	2	IPR021859
Domain	MFS_dom	SLC22A18 SLC16A6 SLC17A3 SV2C SLC45A2 MFSD12	2.55e-05	134	81	6	IPR020846
Domain	MFS	SLC22A18 SLC16A6 SLC17A3 SV2C MFSD12	1.06e-04	108	81	5	PS50850
Domain	Gprotein_alpha_Q	GNA11 GNAQ	1.11e-04	4	81	2	IPR000654
Domain	G-alpha	GNA11 GNAQ	2.14e-03	16	81	2	PF00503
Domain	GproteinA_insert	GNA11 GNAQ	2.14e-03	16	81	2	IPR011025
Domain	-	GNA11 GNAQ	2.14e-03	16	81	2	1.10.400.10
Domain	G_alpha	GNA11 GNAQ	2.14e-03	16	81	2	SM00275
Domain	Gprotein_alpha_su	GNA11 GNAQ	2.42e-03	17	81	2	IPR001019
Domain	DAPIN	PYDC2 NLRP2	4.06e-03	22	81	2	PS50824
Domain	PYRIN	PYDC2 NLRP2	4.06e-03	22	81	2	PF02758
Domain	DAPIN	PYDC2 NLRP2	4.06e-03	22	81	2	IPR004020
Domain	PYRIN	PYDC2 NLRP2	4.06e-03	22	81	2	SM01289
Pathway	PID_TXA2PATHWAY	GNA11 PRKCQ GNAQ PTGDR	8.08e-05	56	58	4	M99
Pathway	WP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA	CACNA1A GNA11 GNAQ	9.63e-05	22	58	3	M39795
Pubmed	GNAQ and GNA11 mutations occur in 9.5% of mucosal melanoma and are associated with poor prognosis.	GNA11 GNAQ	6.33e-06	2	88	2	27498141
Pubmed	Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways.	GNA11 GNAQ	6.33e-06	2	88	2	7492305
Pubmed	Reduced trabecular bone mass and strength in mice overexpressing Gα11 protein in cells of the osteoblast lineage.	GNA11 GNAQ	6.33e-06	2	88	2	24308950
Pubmed	The Role of Mutation Rates of GNAQ or GNA11 in Cases of Uveal Melanoma in Japan.	GNA11 GNAQ	6.33e-06	2	88	2	28248732
Pubmed	Gαq and Gα11 contribute to the maintenance of cellular electrophysiology and Ca2+ handling in ventricular cardiomyocytes.	GNA11 GNAQ	6.33e-06	2	88	2	22562663
Pubmed	Uveal Melanoma: GNAQ and GNA11 Mutations in a Greek Population.	GNA11 GNAQ	6.33e-06	2	88	2	28982892
Pubmed	Mutations in GNA11 in uveal melanoma.	GNA11 GNAQ	6.33e-06	2	88	2	21083380
Pubmed	Activation of Gq/11 in the mouse corpus luteum is required for parturition.	GNA11 GNAQ	6.33e-06	2	88	2	25495873
Pubmed	GNAQ and GNA11 mutations in uveal melanoma.	GNA11 GNAQ	6.33e-06	2	88	2	25304237
Pubmed	Functional specificity of G alpha q and G alpha 11 in the cholinergic and glutamatergic modulation of potassium currents and excitability in hippocampal neurons.	GNA11 GNAQ	6.33e-06	2	88	2	11826096
Pubmed	Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes.	GNA11 GNAQ	6.33e-06	2	88	2	28301547
Pubmed	Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation.	GNA11 GNAQ	6.33e-06	2	88	2	16847339
Pubmed	Blue nevi and variants: an update.	GNA11 GNAQ	6.33e-06	2	88	2	21366456
Pubmed	In uveal melanoma Gα-protein GNA11 mutations convey a shorter disease-specific survival and are more strongly associated with loss of BAP1 and chromosomal alterations than Gα-protein GNAQ mutations.	GNA11 GNAQ	6.33e-06	2	88	2	35580369
Pubmed	Gonadotropin and gonadal steroid release in response to a gonadotropin-releasing hormone agonist in Gqalpha and G11alpha knockout mice.	GNA11 GNAQ	6.33e-06	2	88	2	9607776
Pubmed	Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology.	GNA11 GNAQ	6.33e-06	2	88	2	29570931
Pubmed	Muscarinic inhibition of calcium current and M current in Galpha q-deficient mice.	GNA11 GNAQ	6.33e-06	2	88	2	10818132
Pubmed	Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis.	GNA11 GNAQ	6.33e-06	2	88	2	26272756
Pubmed	NK2 receptor-mediated detrusor muscle contraction involves Gq/11-dependent activation of voltage-dependent Ca2+ channels and the RhoA-Rho kinase pathway.	GNA11 GNAQ	6.33e-06	2	88	2	31461351
Pubmed	Ultradeep sequencing detects GNAQ and GNA11 mutations in cell-free DNA from plasma of patients with uveal melanoma.	GNA11 GNAQ	6.33e-06	2	88	2	23634288
Pubmed	Reverse Phenotyping in Patients with Skin Capillary Malformations and Mosaic GNAQ or GNA11 Mutations Defines a Clinical Spectrum with Genotype-Phenotype Correlation.	GNA11 GNAQ	6.33e-06	2	88	2	31726051
Pubmed	Papillary Hemangioma Harbors Somatic GNA11 and GNAQ Mutations.	GNA11 GNAQ	6.33e-06	2	88	2	37750536
Pubmed	G(alpha)q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region.	GNA11 GNAQ	6.33e-06	2	88	2	11438569
Pubmed	GNAQ/GNA11 Mosaicism Is Associated with Abnormal Serum Calcium Indices and Microvascular Neurocalcification.	GNA11 GNAQ	6.33e-06	2	88	2	37802294
Pubmed	Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis.	GNA11 GNAQ	6.33e-06	2	88	2	26778290
Pubmed	Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.	GNA11 GNAQ	6.33e-06	2	88	2	26628681
Pubmed	Skeletal Muscle-Specific Activation of Gq Signaling Maintains Glucose Homeostasis.	GNA11 GNAQ	6.33e-06	2	88	2	30936140
Pubmed	Distribution of GNAQ and GNA11 Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism.	GNA11 GNAQ	6.33e-06	2	88	2	26368812
Pubmed	Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to cholecystokinin are mediated by a transient receptor potential-like current.	GNA11 GNAQ	6.33e-06	2	88	2	17482476
Pubmed	The time-course of agonist-induced solubilization of trimeric G(q)alpha/G(11)alpha proteins resolved by two-dimensional electrophoresis.	GNA11 GNAQ	6.33e-06	2	88	2	17552882
Pubmed	Patient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11.	GNA11 GNAQ	6.33e-06	2	88	2	23778528
Pubmed	High throughput mass spectrometry-based mutation profiling of primary uveal melanoma.	GNA11 GNAQ	6.33e-06	2	88	2	22977135
Pubmed	An experimental strategy to probe Gq contribution to signal transduction in living cells.	GNA11 GNAQ	6.33e-06	2	88	2	33639168
Pubmed	GNAQ and GNA11 mutant nonuveal melanoma: a subtype distinct from both cutaneous and uveal melanoma.	GNA11 GNAQ	6.33e-06	2	88	2	32064597
Pubmed	Mutational analysis of GNAQ and GNA11 to aid therapy management of a choroidal melanoma metastatic to the contralateral orbit.	GNA11 GNAQ	6.33e-06	2	88	2	23572068
Pubmed	Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations.	GNA11 GNAQ	6.33e-06	2	88	2	31173078
Pubmed	Molecular genetic testing of uveal melanoma from routinely processed and stained cytology specimens.	GNA11 GNAQ	6.33e-06	2	88	2	21945171
Pubmed	Low mutational burden of eight genes involved in the MAPK/ERK, PI3K/AKT, and GNAQ/11 pathways in female genital tract primary melanomas.	GNA11 GNAQ	6.33e-06	2	88	2	25695059
Pubmed	Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations.	GNA11 GNAQ	6.33e-06	2	88	2	24141786
Pubmed	Frequent and Yet Unreported GNAQ and GNA11 Mutations are Found in Uveal Melanomas.	GNA11 GNAQ	6.33e-06	2	88	2	29209985
Pubmed	Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association.	GNA11 GNAQ	6.33e-06	2	88	2	9175863
Pubmed	Group I metabotropic glutamate receptor signaling via Galpha q/Galpha 11 secures the induction of long-term potentiation in the hippocampal area CA1.	GNA11 GNAQ	6.33e-06	2	88	2	12351712
Pubmed	Cardiac remodeling in Gαq and Gα11 knockout mice.	GNA11 GNAQ	6.33e-06	2	88	2	26476043
Pubmed	The ethnic profile of patients with birthmarks reveals interaction of germline and postzygotic genetics.	GNA11 GNAQ	6.33e-06	2	88	2	28083870
Pubmed	Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.	GNA11 GNAQ	6.33e-06	2	88	2	37102682
Pubmed	Early-onset hypertension associated with extensive cutaneous capillary malformations harboring postzygotic variants in GNAQ and GNA11.	GNA11 GNAQ	6.33e-06	2	88	2	36440997
Pubmed	Loss of Gq/11 family G proteins in the nervous system causes pituitary somatotroph hypoplasia and dwarfism in mice.	GNA11 GNAQ	6.33e-06	2	88	2	15713647
Pubmed	Distinct roles of Galpha(q) and Galpha11 for Purkinje cell signaling and motor behavior.	GNA11 GNAQ	6.33e-06	2	88	2	15175381
Pubmed	GNAQ and GNA11 mutations in melanocytomas of the central nervous system.	GNA11 GNAQ	6.33e-06	2	88	2	22307269
Pubmed	Gq/11-Dependent Changes in the Murine Ovarian Transcriptome at the End of Gestation.	GNA11 GNAQ	6.33e-06	2	88	2	26843449
Pubmed	Oncogenic GNAQ and GNA11 mutations in uveal melanoma in Chinese.	GNA11 GNAQ	6.33e-06	2	88	2	25280020
Pubmed	Direct targeting of Gαq and Gα11 oncoproteins in cancer cells.	GNA11 GNAQ	6.33e-06	2	88	2	30890659
Pubmed	Frequent GNAQ, GNA11, and EIF1AX Mutations in Iris Melanoma.	GNA11 GNAQ	1.90e-05	3	88	2	28700778
Pubmed	Dissecting Gq/11-Mediated Plasma Membrane Translocation of Sphingosine Kinase-1.	GNA11 GNAQ	1.90e-05	3	88	2	33003441
Pubmed	P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction.	GNA11 GNAQ	1.90e-05	3	88	2	26168216
Pubmed	Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor.	GNA11 GNAQ	1.90e-05	3	88	2	16988000
Pubmed	The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.	GNA11 GNAQ	1.90e-05	3	88	2	10446129
Pubmed	Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences.	GNA11 GNAQ	1.90e-05	3	88	2	8836152
Pubmed	Gqα/G11α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity.	GNA11 GNAQ	1.90e-05	3	88	2	33166186
Pubmed	Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes.	GNA11 GNAQ	1.90e-05	3	88	2	11689889
Pubmed	Diabetes-related defects in sarcoplasmic Ca2+ release are prevented by inactivation of G(alpha)11 and G(alpha)q in murine cardiomyocytes.	GNA11 GNAQ	1.90e-05	3	88	2	20372981
Pubmed	Prognostic impact of chromosomal aberrations and GNAQ, GNA11 and BAP1 mutations in uveal melanoma.	GNA11 GNAQ	1.90e-05	3	88	2	28444874
Pubmed	Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension.	GNA11 GNAQ	1.90e-05	3	88	2	25595485
Pubmed	Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11).	GNA11 GNAQ	1.90e-05	3	88	2	9481484
Pubmed	The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects.	GNA11 GNAQ	1.90e-05	3	88	2	32576659
Pubmed	High frequency of GNA14, GNAQ, and GNA11 mutations in cherry hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms.	GNA11 GNAQ	1.90e-05	3	88	2	31189994
Pubmed	Heterotrimeric G alpha q/G alpha 11 proteins function upstream of vascular endothelial growth factor (VEGF) receptor-2 (KDR) phosphorylation in vascular permeability factor/VEGF signaling.	GNA11 GNAQ	1.90e-05	3	88	2	12670961
Pubmed	Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development.	GNA11 GNAQ	1.90e-05	3	88	2	17694176
Pubmed	GNAS, GNAQ, and GNA11 alterations in patients with diverse cancers.	GNA11 GNAQ	1.90e-05	3	88	2	30204251
Pubmed	Identification of HRAS mutations and absence of GNAQ or GNA11 mutations in deep penetrating nevi.	GNA11 GNAQ	1.90e-05	3	88	2	23599145
Pubmed	Heterotrimeric G proteins of the Gq/11 family are crucial for the induction of maternal behavior in mice.	GNA11 GNAQ	1.90e-05	3	88	2	15340067
Pubmed	Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential.	GNA11 GNAQ	1.90e-05	3	88	2	30783010
Pubmed	Galphao2 regulates vesicular glutamate transporter activity by changing its chloride dependence.	GNA11 GNAQ	1.90e-05	3	88	2	15872115
Pubmed	Uterine Gαq/11 signaling, in a progesterone-dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse.	GNA11 GNAQ	1.90e-05	3	88	2	31091422
Pubmed	GNA11 and N-RAS mutations: alternatives for MAPK pathway activating GNAQ mutations in primary melanocytic tumours of the central nervous system.	GNA11 GNAQ	1.90e-05	3	88	2	22758774
Pubmed	Regulation of the epithelial Na+ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Galphaq/11.	GNA11 GNAQ	1.90e-05	3	88	2	21464134
Pubmed	G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.	GNA11 GNAQ	1.90e-05	3	88	2	2123549
Pubmed	G(q/11)α and G(s)α mediate distinct physiological responses to central melanocortins.	GNA11 GNAQ	1.90e-05	3	88	2	26595811
Pubmed	The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway.	GNA11 GNAQ	1.90e-05	3	88	2	18991294
Pubmed	Tamoxifen-inducible Cre-mediated recombination in adipocytes.	GNA11 GNAQ	1.90e-05	3	88	2	20715175
Pubmed	Selective inhibition of Cav3.3 T-type calcium channels by Galphaq/11-coupled muscarinic acetylcholine receptors.	GNA11 GNAQ	1.90e-05	3	88	2	17535809
Pubmed	CXCL2/CXCR2 axis induces cancer stem cell characteristics in CPT-11-resistant LoVo colon cancer cells via Gαi-2 and Gαq/11.	GNA11 GNAQ	1.90e-05	3	88	2	30552676
Pubmed	Intraocular Metastasis in Unilateral Multifocal Uveal Melanoma Without Melanocytosis or Germline BAP1 Mutations.	GNA11 GNAQ	1.90e-05	3	88	2	31580399
Pubmed	G alpha(q) signal in osteoblasts is inhibitory to the osteoanabolic action of parathyroid hormone.	GNA11 GNAQ	1.90e-05	3	88	2	21345793
Pubmed	Normal hematopoiesis and inflammatory responses despite discrete signaling defects in Galpha15 knockout mice.	GNA11 GNAQ	1.90e-05	3	88	2	10629036
Pubmed	GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH Secretion.	GNA11 GNAQ	3.79e-05	4	88	2	26377475
Pubmed	Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Gα(q/11)--p63RhoGEF--RhoA axis.	GNA11 GNAQ	3.79e-05	4	88	2	23696743
Pubmed	Galpha12/13 is essential for directed cell migration and localized Rho-Dia1 function.	GNA11 GNAQ	3.79e-05	4	88	2	16251183
Pubmed	Interactions of Rabconnectin-3 with Cav2 calcium channels.	CACNA1A WDR7	3.79e-05	4	88	2	31253182
Pubmed	Promiscuous coupling of receptors to Gq class alpha subunits and effector proteins in pancreatic and submandibular gland cells.	GNA11 GNAQ	3.79e-05	4	88	2	9765251
Pubmed	Ric-8A gene deletion or phorbol ester suppresses tumorigenesis in a mouse model of GNAQ(Q209L)-driven melanoma.	GNA11 GNAQ	3.79e-05	4	88	2	27348266
Pubmed	Deletion of Gαq/11 or Gαs Proteins in Gonadotropes Differentially Affects Gonadotropin Production and Secretion in Mice.	GNA11 GNAQ	3.79e-05	4	88	2	34864945
Pubmed	The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice.	GNA11 GNAQ	3.79e-05	4	88	2	20440069
Pubmed	Antagonistic regulation of neurite morphology through Gq/G11 and G12/G13.	GNA11 GNAQ	3.79e-05	4	88	2	18854320
Pubmed	Beyond the brain-Peripheral kisspeptin signaling is essential for promoting endometrial gland development and function.	GNA11 GNAQ	3.79e-05	4	88	2	27364226
Pubmed	Negative and positive regulatory epitopes in the C-terminal domains of the human B1 and B2 bradykinin receptor subtypes determine receptor coupling efficacy to G(q/11)-mediated [correction of G(9/11)-mediated] phospholipase Cbeta activity.	GNA11 GNAQ	3.79e-05	4	88	2	12130679
Pubmed	Genomic Profiling of Metastatic Uveal Melanoma Shows Frequent Coexisting BAP1 or SF3B1 and GNAQ/GNA11 Mutations and Correlation With Prognosis.	GNA11 GNAQ	3.79e-05	4	88	2	35212356
Pubmed	SOX10 Expression as Well as BRAF and GNAQ/11 Mutations Distinguish Pigmented Ciliary Epithelium Neoplasms From Uveal Melanomas.	GNA11 GNAQ	3.79e-05	4	88	2	29059311
Pubmed	Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice.	GNA11 GNAQ	3.79e-05	4	88	2	9687499
Pubmed	Comparative analysis of the GNAQ, GNA11, SF3B1, and EIF1AX driver mutations in melanoma and across the cancer spectrum.	GNA11 GNAQ	3.79e-05	4	88	2	27089234
Interaction	CRELD1 interactions	SLC22A18 DOLK RER1 UGT8 ALG8 TMEM38B MFSD12	4.19e-06	163	81	7	int:CRELD1
GeneFamily	Solute carriers	SLC22A18 SLC9C1 SLC16A6 SLC17A3 SLC45A2 SLC45A1 SLC52A3	2.08e-04	395	56	7	752
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D231\|Adult / Lineage, Cell type, age group and donor	SPTB SV2C SLC45A2 PDE10A GPR108 ADGRL4 CC2D2B	4.39e-08	168	88	7	aca34c51758c65925ad24110294a72b2dea6db72
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	MYCBP2 WDR7 DDHD1 GNPTAB CEMIP2 DOP1B	2.20e-06	191	88	6	9454f642c3621370fa23640b631301346b300950
Disease	Phakomatosis cesioflammea	GNA11 GNAQ	7.26e-06	2	80	2	C3838883
Disease	Congenital hemangioma	GNA11 GNAQ	7.26e-06	2	80	2	C0235753
Disease	Port-wine stain with oculocutaneous melanosis	GNA11 GNAQ	7.26e-06	2	80	2	C1274879
Disease	soluble transferrin receptor measurement, iron biomarker measurement	SLC17A3 TMPRSS6	7.22e-05	5	80	2	EFO_0004460, EFO_0004461
Disease	2'-O-methylcytidine measurement	DOLK NUP188	7.22e-05	5	80	2	EFO_0800635
Disease	Malignant melanoma of iris	GNA11 GNAQ	7.22e-05	5	80	2	C0346373
Disease	Malignant melanoma of choroid	GNA11 GNAQ	7.22e-05	5	80	2	C0346388
Disease	Uveal melanoma	GNA11 GNAQ	2.01e-04	8	80	2	C0220633
Disease	cerebellar ataxia (implicated_via_orthology)	CACNA1A AARS2	2.01e-04	8	80	2	DOID:0050753 (implicated_via_orthology)
Disease	calcium measurement	TRPM6 SLC22A18 MCHR1 TMEM147 DNAH2 UGT8 GNA11 GNAQ	3.04e-04	628	80	8	EFO_0004838
Disease	hepcidin:ferritin ratio	SLC17A3 TMPRSS6 SV2C	4.55e-04	55	80	3	EFO_0007901
Disease	congenital disorder of glycosylation type I (implicated_via_orthology)	DOLK ALG8	7.45e-04	15	80	2	DOID:0050570 (implicated_via_orthology)
Disease	bipolar disorder	DPY19L3 TMEM217 MCHR1 GNAQ PDE10A PRSS36 ADGRL4	9.77e-04	577	80	7	MONDO_0004985
Disease	PCSK9 protein measurement	PRORP ADGRL4	2.26e-03	26	80	2	EFO_0006899
Disease	white matter integrity, age at assessment	WDR7 CDKN2AIP	2.26e-03	26	80	2	EFO_0004641, EFO_0008007

Protein segments in the cluster

Peptide	Gene	Start	Entry
FLAAFAWMCIEGIHL	ADGRL4	501	Q9HBW9
FAVLTVFQCITMEGW	CACNA1A	306	O00555
AVAWCYSGSHMVSVD	ATG16L2	596	Q8NAA4
ISKGEIMNEWFHFTC	ABCA10	126	Q8WWZ4
IMNEWFHFTCLVSFS	ABCA10	131	Q8WWZ4
TLLSSFGAWDHICNM	COQ6	96	Q9Y2Z9
STDIWLMFVGSLCAF	ABCB11	56	O95342
MEIVLSWGLAAHCTA	BTBD11	166	A6QL63
LWTSHMCVFASFGLC	DPY19L3	486	Q6ZPD9
DIWMTSEHCISLAIG	CC2D2B	1166	Q6DHV5
ATVMLPDHSFCDSLW	NBEAL1	651	Q6ZS30
TWCFIQMVHEEGSLS	PTGDR	181	Q13258
WIHCFENVTSIMFLV	GNAQ	216	P50148
LWFHSMDISFGSCVS	OR52Z1P	71	P0C646
SYFLSGENCVVMVWH	BCAN	776	Q96GW7
CTALISASWMGGFVH	OR4D11	141	Q8NGI4
ICLGCFSHQWLVSTM	SLC17A3	221	O00476
GWIHAVLTSQDCMAF	KDM7A	351	Q6ZMT4
WEHPFLTHMFCTFQT	PRKCQ	436	Q04759
HTLVIFTMSFLCSWL	KCNJ8	71	Q15842
GTWASSIFFHLMTCV	DOLK	251	Q9UPQ8
WTHCVLATLIMFTIF	GNPTAB	1211	Q3T906
EFLFWASLCMTHLSR	ASL	241	P04424
HLDRFSILMTSCTSW	LINC02693	86	A8MQB3
FFQMDTSCVHWKSII	DOP1B	1981	Q9Y3R5
ISFSMAWANHVFLGC	CDKN2AIP	76	Q9NXV6
CKVSGYTLTELSMHW	IGHV1-24	41	A0A0C4DH33
SYHSICTSEEWQGLM	PDE10A	436	Q9Y233
FMWQLGDTDTCFQIH	KRIT1	686	O00522
DQHMLPFWTDLCSIF	NLRP2	681	Q9NX02
WFIHTCMAAKSLTIV	GPR151	116	Q8TDV0
SCSHNFWLAIDMSFE	IFNAR2	121	P48551
HWIFGDTMCRLTSYV	NPY6R	101	Q99463
WVLSAAHCFMTNGTL	PRSS36	81	Q5K4E3
VSWSITDQFATMCHG	GLYATL3	201	Q5SZD4
MLESAAHPGWFICTS	IL37	166	Q9NZH6
DQGCHTTMEHLFWSF	ELOVL3	226	Q9HB03
CNHTIMTIGTFGIWA	FUT2	281	Q10981
WIHCFENVTSIMFLV	GNA11	216	P29992
YDLVHGSSLWMLCTD	UGT8	231	Q16880
WSISESGHICSQMFE	CRYBG2	1611	Q8N1P7
ATDCMAVSTFWIAHP	CEMIP2	656	Q9UHN6
TFCFQMSWQTLCHLG	MBOAT4	86	Q96T53
GVWHFGETMCTLITA	MCHR1	176	Q99705
DQMAIFHCLFWPSLT	KCNMB3	206	Q9NPA1
HSLGCVITYDIMTGW	DDHD1	536	Q8NEL9
MSTFFSDTAWICLAV	HSD17B2	1	P37059
TFVFSMIWSVCASVD	DNAH2	2316	Q9P225
AGHYTSAMLWVAFLC	DUOXA1	176	Q1HG43
CVNHFLGWLSFEGML	SLC45A1	561	Q9Y2W3
CISHLIGWTAFLSNM	SLC45A2	321	Q9UMX9
AVGHFLNDLCASMWF	MFSD12	26	Q6NUT3
FTFATEFWGLMSCSI	SLC16A6	376	O15403
FWHAATKGILVAMVC	RER1	121	O15258
PGWHIECSAIASMVF	CARS2	251	Q9HA77
AMASEHSTLAAGWIC	RPGRIP1	706	Q96KN7
VGTVTCIIFAFLWNM	SLC52A3	81	Q9NQ40
GISCFFLWFGTSESM	SV2C	621	Q496J9
GHEFSWRWIFIMVCS	SLC9C1	356	Q4G0N8
DISDIMFVTTFFCWH	TEDDM1	191	Q5T9Z0
FFCWHVMINASFLLG	TEDDM1	201	Q5T9Z0
VMSACFLAAGIFWVS	GPR108	266	Q9NPR9
WMFHAVTLFLNIFGC	SCAMP1	156	O15126
AHTCVLMKNGEVWTF	MYCBP2	691	O75592
FAVLSLCWHLSGDSM	WRAP73	416	Q9P2S5
ESWIISQMAGCHSSI	PRORP	141	O15091
TFTAEAWALAVCSHM	AARS2	936	Q5JTZ9
AMAWMSSVFHFCLLV	SLC22A18	321	Q96BI1
LTLCALSSFMFGWHV	ALG8	366	Q9BVK2
SLSMVWANHLFLGCS	CDKN2AIPNL	66	Q96HQ2
HSWSNVICAEVLGSM	TRPM6	1251	Q9BX84
SWSSGMAFCALIHKF	SMTNL1	406	A8MU46
TSIHLMGIWCYTFAE	RMDN1	206	Q96DB5
DCGMVFTWVTHFIEH	ZSCAN1	296	Q8NBB4
NPISSWFTAMLHCFG	TMEM38B	46	Q9NVV0
SFHYISMGDCTGWLE	RAET1G	181	Q6H3X3
FSLGMWSCLHAVLEL	NUP188	951	Q5SRE5
FCDFLGSLMSVWVTV	TMEM8B	296	A6NDV4
MWESRSHTLAQCLGF	SPTB	1156	P11277
EIFICSFSSSWLQMF	SLF1	666	Q9BQI6
VEIFTSHSCSYWAGM	PYDC2	56	Q56P42
WFFPIIGHMGICTST	TMEM222	66	Q9H0R3
GLVSRTVMHCFWMFF	TMEM217	131	Q8N7C4
FVMETFVHLCSLGSW	TMEM147	181	Q9BVK8
IWDIFSGEMKHIFCV	WDR7	496	Q9Y4E6
VEFLWSHTTESMCVG	TASP1	366	Q9H6P5
AHCFQEDSMASTVLW	TMPRSS6	616	Q8IU80
LCFMFLDSSSVWFVT	TAS2R4	86	Q9NYW5
TSFHDVLCLGLMLWA	VN1R2	266	Q8NFZ6
CFSHKTWVFSVLMGS	MLC1	46	Q15049
EDFEMLSFWLSNTCH	MYO5C	1436	Q9NQX4