Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	increased urine microglobulin level	LRP2 GPRC6A	2.77e-05	3	43	2	MP:0011555
Domain	Myotonic_dystrophy_kinase_coil	CDC42BPG CDC42BPB	5.28e-05	4	56	2	IPR014930
Domain	Myotonic_dystrophy_kinase_coil	CDC42BPG CDC42BPB	5.28e-05	4	56	2	PD011252
Domain	DMPK_coil	CDC42BPG CDC42BPB	5.28e-05	4	56	2	PF08826
Domain	CNH	CDC42BPG CDC42BPB	7.85e-04	14	56	2	SM00036
Domain	CNH	CDC42BPG CDC42BPB	9.04e-04	15	56	2	PF00780
Domain	CNH	CDC42BPG CDC42BPB	9.04e-04	15	56	2	PS50219
Domain	CNH_dom	CDC42BPG CDC42BPB	9.04e-04	15	56	2	IPR001180
Domain	PBD	CDC42BPG CDC42BPB	1.17e-03	17	56	2	PF00786
Domain	CRIB	CDC42BPG CDC42BPB	1.62e-03	20	56	2	PS50108
Domain	-	MAP1S ELAC1	1.62e-03	20	56	2	3.60.15.10
Domain	Metallo-B-lactamas	MAP1S ELAC1	1.62e-03	20	56	2	IPR001279
Domain	CRIB_dom	CDC42BPG CDC42BPB	1.79e-03	21	56	2	IPR000095
Domain	M10A_MMP	MMP25 MMP23B	2.15e-03	23	56	2	IPR033739
Domain	Pept_M10A	MMP25 MMP23B	2.15e-03	23	56	2	IPR021190
Domain	EGF_CA	FAT3 LRP2 VWCE	2.19e-03	86	56	3	PF07645
Domain	Peptidase_M10	MMP25 MMP23B	2.34e-03	24	56	2	PF00413
Domain	EGF_Ca-bd_CS	FAT3 LRP2 VWCE	3.08e-03	97	56	3	IPR018097
Domain	EGF_CA	FAT3 LRP2 VWCE	3.27e-03	99	56	3	PS01187
Domain	ASX_HYDROXYL	FAT3 LRP2 VWCE	3.36e-03	100	56	3	PS00010
Domain	ZnMc	MMP25 MMP23B	3.40e-03	29	56	2	SM00235
Domain	Peptidase_Metallo	MMP25 MMP23B	3.40e-03	29	56	2	IPR006026
Domain	EGF-type_Asp/Asn_hydroxyl_site	FAT3 LRP2 VWCE	3.96e-03	106	56	3	IPR000152
Domain	Pkinase_C	CDC42BPG CDC42BPB	5.50e-03	37	56	2	IPR017892
Domain	EGF_CA	FAT3 LRP2 VWCE	5.86e-03	122	56	3	SM00179
Domain	EGF-like_Ca-bd_dom	FAT3 LRP2 VWCE	6.13e-03	124	56	3	IPR001881
Domain	Pkinase_C	CDC42BPG CDC42BPB	7.04e-03	42	56	2	PF00433
Domain	Pept_M10_metallopeptidase	MMP25 MMP23B	7.37e-03	43	56	2	IPR001818
Pathway	PID_SMAD2_3NUCLEAR_PATHWAY	RBBP4 GATA3 FOXO4 IRF7	4.85e-05	82	35	4	M2
Pathway	WP_TOLLLIKE_RECEPTOR_SIGNALING_RELATED_TO_MYD88	TLR3 IRF7 RELB	6.01e-05	31	35	3	M39573
Pubmed	Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1.	TLR3 IRF7 RELB	1.02e-07	6	61	3	22065573
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TNRC18 MAP1S SGSM2 POLG FBRS NLRC5 RELB ITGA3 RALGAPA2 CDC42BPB ABCA7	3.09e-06	1105	61	11	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	METTL13 INO80C EARS2 RBBP4 FAT3 FBRS XRN1 LRP2 ITGA3 RALGAPA2 ABCA7	3.40e-06	1116	61	11	31753913
Pubmed	ERVs-TLR3-IRF axis is linked to myelodysplastic syndrome pathogenesis.	TLR3 IRF7	9.07e-06	3	61	2	33594613
Pubmed	Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions.	CDC42BPB ZIC1 LHX9	1.63e-05	28	61	3	35942939
Pubmed	Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors.	TLR3 IRF7	1.81e-05	4	61	2	22308357
Pubmed	Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons.	TLR3 IRF7	3.02e-05	5	61	2	23042151
Pubmed	A TLR3-Specific Adjuvant Relieves Innate Resistance to PD-L1 Blockade without Cytokine Toxicity in Tumor Vaccine Immunotherapy.	TLR3 IRF7	4.52e-05	6	61	2	28564605
Pubmed	Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors.	TLR3 IRF7	6.32e-05	7	61	2	23142781
Pubmed	Age-dependent myeloid dendritic cell responses mediate resistance to la crosse virus-induced neurological disease.	TLR3 IRF7	6.32e-05	7	61	2	25008929
Pubmed	MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion.	CDC42BPG CDC42BPB	6.32e-05	7	61	2	29162624
Pubmed	IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.	TLR3 IRF7	6.32e-05	7	61	2	12692549
Pubmed	IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways.	TLR3 IRF7	6.32e-05	7	61	2	16484229
Pubmed	I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection.	IRF7 RELB	8.42e-05	8	61	2	23422957
Pubmed	Toll-like receptor ligands induce expression of the costimulatory molecule CD155 on antigen-presenting cells.	TLR3 IRF7	8.42e-05	8	61	2	23349877
Pubmed	The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection.	TLR3 IRF7	8.42e-05	8	61	2	21998457
Pubmed	An innate antiviral pathway acting before interferons at epithelial surfaces.	TLR3 IRF7	8.42e-05	8	61	2	26595890
Pubmed	Molecular Fingerprint and Developmental Regulation of the Tegmental GABAergic and Glutamatergic Neurons Derived from the Anterior Hindbrain.	GATA3 ZIC1 LHX9	1.33e-04	56	61	3	33053343
Pubmed	Type I Interferon Induced by Streptococcus suis Serotype 2 is Strain-Dependent and May Be Beneficial for Host Survival.	TLR3 IRF7	1.35e-04	10	61	2	28894449
Pubmed	Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner.	TLR3 IRF7	1.35e-04	10	61	2	19474102
Pubmed	Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.	TLR3 IRF7	1.65e-04	11	61	2	20975040
Pubmed	Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection.	TLR3 IRF7	1.65e-04	11	61	2	20107183
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	ALX3 LRP2	1.65e-04	11	61	2	24639464
Pubmed	Persistence of Integrase-Deficient Lentiviral Vectors Correlates with the Induction of STING-Independent CD8+ T Cell Responses.	TLR3 IRF7	1.65e-04	11	61	2	30699352
Pubmed	Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner.	TLR3 IRF7	1.97e-04	12	61	2	29632368
Pubmed	HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection.	TLR3 IRF7	1.97e-04	12	61	2	30209176
Pubmed	Inducible interleukin 32 (IL-32) exerts extensive antiviral function via selective stimulation of interferon λ1 (IFN-λ1).	IRF7 RELB	1.97e-04	12	61	2	23729669
Pubmed	Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.	GATA3 RELB OTOP3	2.81e-04	72	61	3	25917818
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	CDC42BPG MAP1S EARS2 ITGA3	3.06e-04	183	61	4	31932471
Pubmed	Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.	TLR3 IRF7	3.13e-04	15	61	2	24362933
Pubmed	Tcf7l2 transcription factor is required for the maintenance, but not the initial specification, of the neurotransmitter identity in the caudal thalamus.	GATA3 LHX9	3.57e-04	16	61	2	31872525
Pubmed	Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality.	TLR3 IRF7	3.57e-04	16	61	2	27793594
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	ALX3 GATA3 FOXO4 IRF7 ZIC1 LHX9	3.82e-04	544	61	6	28473536
Pubmed	Hydroxypropyl-β-cyclodextrin spikes local inflammation that induces Th2 cell and T follicular helper cell responses to the coadministered antigen.	TLR3 IRF7	5.08e-04	19	61	2	25681338
Pubmed	TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.	TLR3 IRF7	5.08e-04	19	61	2	28400473
Pubmed	Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney.	GATA3 ITGA3	5.08e-04	19	61	2	16319112
Pubmed	Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.	TLR3 IRF7	5.63e-04	20	61	2	32150572
Pubmed	Canonical notch signaling functions as a commitment switch in the epidermal lineage.	GATA3 ITGA3	6.22e-04	21	61	2	17079689
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP25 MMP23B	6.83e-04	22	61	2	23421805
Pubmed	Matrix metalloproteinases.	MMP25 MMP23B	6.83e-04	22	61	2	10419448
Pubmed	FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation.	ZIC1 LHX9	7.48e-04	23	61	2	19668217
Pubmed	Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development.	ELAC1 ZIC1	7.48e-04	23	61	2	21937600
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	NPPB LRP2 ITGA3	7.57e-04	101	61	3	23382219
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TNRC18 MORN4 MAP1S RBBP4 XRN1 FAM91A1 EMC8 CDC42BPB	8.16e-04	1139	61	8	36417873
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ALX3 ZBTB25 GATA3 IRF7 RELB ZIC1 LHX9	8.46e-04	877	61	7	20211142
Pubmed	β-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus.	GATA3 LHX9	8.84e-04	25	61	2	22745311
Pubmed	Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.	TNRC18 RBBP4 XRN1	9.69e-04	110	61	3	26841866
Pubmed	A census of human transcription factors: function, expression and evolution.	ALX3 GATA3 FOXO4 IRF7 RELB ZIC1 LHX9	1.03e-03	908	61	7	19274049
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	METTL13 POM121 EARS2 FBRS XRN1	1.25e-03	457	61	5	32344865
Pubmed	Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects.	ALX3 GATA3	1.28e-03	30	61	2	38404688
Pubmed	Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress.	NPPB IRF7	1.36e-03	31	61	2	38395995
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	METTL13 TNRC18 POM121 RALGAPA2 CDC42BPB	1.74e-03	493	61	5	15368895
Cytoband	8q24.13	FAM91A1 ATAD2	1.03e-03	36	60	2	8q24.13
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP25 MMP23B	1.03e-03	24	36	2	891
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MAP1S FAT3 FOXO4 GPRC6A DEGS2	7.64e-06	198	61	5	dd0465b45b02cb8edf0914d19afb52fcaaeb012c
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	METTL13 TNRC18 MAP1S FBRS CPED1	7.83e-06	199	61	5	bbb4798d6a24e756fea744a151ba67c1bafbac9a
Drug	imidazoquinoline	PRTN3 TLR3 GATA3 IRF7 RELB	6.44e-06	101	59	5	CID005351568
Disease	cerebral cavernous malformation (implicated_via_orthology)	CDC42BPG CDC42BPB	2.06e-04	11	58	2	DOID:0060669 (implicated_via_orthology)
Disease	nephrosis (biomarker_via_orthology)	NPPB LRP2	8.55e-04	22	58	2	DOID:2527 (biomarker_via_orthology)
Disease	azoospermia (implicated_via_orthology)	CDC42BPG CDC42BPB	1.29e-03	27	58	2	DOID:14227 (implicated_via_orthology)
Disease	caudate nucleus volume	FAT3 DEGS2	1.59e-03	30	58	2	EFO_0004830
Disease	Inflammation	NPPB GATA3 IRF7	2.02e-03	127	58	3	C0021368
Disease	SAPHO syndrome	TCERG1L DEGS2	2.17e-03	35	58	2	EFO_1001164

Protein segments in the cluster

Peptide	Gene	Start	Entry
HSVFLVPGLAAHPGS	nan	81	A8MUN3
LGIGFHLPVDGVHFL	CPED1	891	A4D0V7
GIYSIHGFPPTLGGH	ALX3	296	O95076
PLHGGHLGFFEGSVL	ABHD2	371	P08910
FLLLSAPHGGSGLHT	ERP29	21	P30040
PGFGQGSHLAPAVIH	ATAD2	801	Q6PL18
FSPFGILHVHPVEGS	DNHD1	326	Q96M86
GLFPPSGGSAFILGH	ABCA7	856	Q8IZY2
ILDHFLPNHGSGPFL	RELB	441	Q01201
PSHGAFSGHHLPFVG	CDC42BPG	381	Q6DT37
TLAHAFFPGEHPISG	MMP25	191	Q9NPA2
HPATAPFHLHGAIFG	OTOP3	326	Q7RTS5
PFHLHGAIFGPLLGL	OTOP3	331	Q7RTS5
STPGFLLLGFSEHPG	OR2H2	6	O95918
GELLLQTGGFSPHHF	MAP1S	126	Q66K74
AAFLVGSFHGVFPGP	MAFIP	6	Q8WZ33
GLHGIGETVHVPFPF	FAM91A1	606	Q658Y4
GFSLQHPGVTGPLHT	FOXO4	326	P98177
HPSLLLHGPSGSAFG	ITGA3	356	P26006
RPPAMLFHGISGGHI	LHX9	16	Q9NQ69
HGGSLIPHPFGVSLF	LRP2	596	P98164
FLHLAFLGGRSHPLG	NPPB	16	P16860
GPFLAHTHAGLQAPG	IRF7	156	Q92985
ALLSTHPFVPFGFGG	FAM181B	6	A6NEQ2
EILPPGSHTGFSGLH	CDC42BPB	381	Q9Y5S2
GSHTGFSGLHLPFIG	CDC42BPB	386	Q9Y5S2
PGSHFCGGTLIHPSF	PRTN3	51	P24158
LGHYPLSGGPAILHS	RALGAPA2	1386	Q2PPJ7
RVLHLPFSHLGPGGA	NLRC5	1691	Q86WI3
DGPPELLFIHGGHTA	RBBP4	361	Q09028
VGGHPSFPGHAWLTF	IGF2BP2-AS1	126	Q96M15
TSPGHIIIGGLFAIH	GPRC6A	31	Q5T6X5
IHPIFGGATHSAFGL	POM121	1026	Q96HA1
LPFKDPNFVHSGHGG	INO80C	81	Q6PI98
FAHFPLGSTLGFHVP	OTOS	71	Q8NHW6
LSGGHASPHLFTFPP	GATA3	141	P23771
HGPFLSPSTHIDPFG	FBRS	161	Q9HAH7
SFPGIPLHHIFSAAG	CDK7	251	P50613
QGLPGTGPLGFHFTH	FAT3	31	Q8TDW7
SFLGLGLHPISGHFV	DEGS2	216	Q6QHC5
SGSSPGLFHHILVGL	FIMP	96	Q96LL3
PQASTGRGHPLGFHL	C2orf81	251	A6NN90
HLPLGGPGAHHTLFV	EMC8	41	O43402
GPIGSGHQFFPWIHI	SDR39U1	181	Q9NRG7
HFPSVPRAAFPGLGH	CHADL	436	Q6NUI6
GLGGGSLPLFVHDHF	METTL13	501	Q8N6R0
TGHGGPQFVADHPFL	SERPINB2	381	P05120
FPVILGTHLPFFIHG	PIGB	316	Q92521
LPHIGGGHIPLGLVF	POLG	226	A0A3B3IS91
GLHGIGETVHVPFPF	LINC00869	251	P0C866
GELAHAFFPPHGGIH	MMP23B	166	O75900
PHPSFVAHLGGVAVG	RHBDL3	336	P58872
PLHFPQGGHLLSFLS	SGSM2	351	O43147
FAPSPTGFLHLGGLR	EARS2	41	Q5JPH6
HLHTHVSGSLPFGVP	ZBTB25	256	P24278
HPFPALHGQWLFGGH	TCERG1L	106	Q5VWI1
LNLHPHPGEAFLGSF	TNRC18	56	O15417
PGGPIYFLKGLSHLH	TLR3	551	O15455
HGPHSLALGLTATFP	VWCE	821	Q96DN2
GFLVGNDFIPHLPHL	XRN1	286	Q8IZH2
AFFLGLSGAGPIHLP	PRAC2	31	D3DTV9
THLHGDHFFGLPGLL	ELAC1	61	Q9H777
PHGHTDAAGHLLFPG	ZIC1	131	Q15915
EFLAHLFVLPGGFGP	STRCP1	1631	A6NGW2
GFGLLTFPDGSHGIP	MORN4	96	Q8NDC4