Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cadherin binding	MACF1 TBC1D10A SWAP70 PTPRO TRPC4	1.62e-04	339	31	5	GO:0045296
GeneOntologyBiologicalProcess	podocyte differentiation	MAGI2 ASXL1 PTPRO	4.64e-06	22	31	3	GO:0072112
GeneOntologyBiologicalProcess	glomerular epithelial cell differentiation	MAGI2 ASXL1 PTPRO	4.64e-06	22	31	3	GO:0072311
GeneOntologyBiologicalProcess	renal filtration cell differentiation	MAGI2 ASXL1 PTPRO	4.64e-06	22	31	3	GO:0061318
GeneOntologyBiologicalProcess	glomerular epithelium development	MAGI2 ASXL1 PTPRO	5.33e-06	23	31	3	GO:0072010
GeneOntologyBiologicalProcess	epithelial cell differentiation involved in kidney development	MAGI2 ASXL1 PTPRO	4.77e-05	47	31	3	GO:0035850
GeneOntologyBiologicalProcess	cell differentiation involved in kidney development	MAGI2 ASXL1 PTPRO	8.51e-05	57	31	3	GO:0061005
GeneOntologyBiologicalProcess	glomerular epithelial cell development	MAGI2 ASXL1	9.76e-05	10	31	2	GO:0072310
GeneOntologyBiologicalProcess	podocyte development	MAGI2 ASXL1	9.76e-05	10	31	2	GO:0072015
GeneOntologyBiologicalProcess	glomerulus development	MAGI2 ASXL1 PTPRO	2.09e-04	77	31	3	GO:0032835
Domain	WW	FNBP4 MAGI2 MAGI3	6.39e-05	47	31	3	PF00397
Domain	WW	FNBP4 MAGI2 MAGI3	6.81e-05	48	31	3	SM00456
Domain	WW_DOMAIN_2	FNBP4 MAGI2 MAGI3	8.17e-05	51	31	3	PS50020
Domain	WW_DOMAIN_1	FNBP4 MAGI2 MAGI3	8.17e-05	51	31	3	PS01159
Domain	WW_dom	FNBP4 MAGI2 MAGI3	8.66e-05	52	31	3	IPR001202
Domain	Guanylate_kinase_CS	MAGI2 MAGI3	3.15e-04	16	31	2	IPR020590
Domain	P-loop_NTPase	MAGI2 MAGI3 LRRIQ1 MTIF2 RAD54B RIT2 DDX10	3.92e-04	848	31	7	IPR027417
Domain	GUANYLATE_KINASE_2	MAGI2 MAGI3	6.60e-04	23	31	2	PS50052
Domain	GUANYLATE_KINASE_1	MAGI2 MAGI3	6.60e-04	23	31	2	PS00856
Domain	Guanylate_kin	MAGI2 MAGI3	8.45e-04	26	31	2	PF00625
Domain	GK/Ca_channel_bsu	MAGI2 MAGI3	8.45e-04	26	31	2	IPR008145
Domain	Guanylate_kin-like_dom	MAGI2 MAGI3	8.45e-04	26	31	2	IPR008144
Domain	GuKc	MAGI2 MAGI3	8.45e-04	26	31	2	SM00072
Domain	Homeobox	HOXA4 NKX6-1 NANOGNB	6.74e-03	234	31	3	PF00046
Domain	HOMEOBOX_1	HOXA4 NKX6-1 NANOGNB	6.90e-03	236	31	3	PS00027
Domain	HOX	HOXA4 NKX6-1 NANOGNB	6.98e-03	237	31	3	SM00389
Domain	Homeobox_dom	HOXA4 NKX6-1 NANOGNB	7.14e-03	239	31	3	IPR001356
Domain	HOMEOBOX_2	HOXA4 NKX6-1 NANOGNB	7.14e-03	239	31	3	PS50071
Domain	Homeobox_metazoa	HOXA4 NKX6-1	9.75e-03	90	31	2	IPR020479
Domain	-	HOXA4 NKX6-1 NANOGNB	1.13e-02	283	31	3	1.10.10.60
Domain	Helicase_C	RAD54B DDX10	1.36e-02	107	31	2	PF00271
Domain	HELICc	RAD54B DDX10	1.36e-02	107	31	2	SM00490
Domain	Helicase_C	RAD54B DDX10	1.38e-02	108	31	2	IPR001650
Domain	HELICASE_CTER	RAD54B DDX10	1.41e-02	109	31	2	PS51194
Domain	HELICASE_ATP_BIND_1	RAD54B DDX10	1.41e-02	109	31	2	PS51192
Domain	DEXDc	RAD54B DDX10	1.41e-02	109	31	2	SM00487
Domain	Helicase_ATP-bd	RAD54B DDX10	1.43e-02	110	31	2	IPR014001
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	FNBP4 MAGI2 MAGI3 MACF1 SWAP70	1.25e-07	130	32	5	12421765
Pubmed	Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein.	MAGI2 MAGI3	2.46e-06	3	32	2	15652357
Pubmed	Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice.	HOXA4 ASXL1	8.19e-06	5	32	2	19833123
Pubmed	Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development.	MAGI2 MAGI3	1.23e-05	6	32	2	15509766
Pubmed	Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis.	MAGI2 MAGI3	1.72e-05	7	32	2	24025447
Pubmed	Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia.	MAGI2 RIT2	2.29e-05	8	32	2	23007406
Pubmed	Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins.	MAGI2 MAGI3	2.29e-05	8	32	2	16316992
Pubmed	Role of SAP97 protein in the regulation of corticotropin-releasing factor receptor 1 endocytosis and extracellular signal-regulated kinase 1/2 signaling.	MAGI2 MAGI3	6.36e-05	13	32	2	23576434
Pubmed	Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density.	MAGI2 MAGI3	8.55e-05	15	32	2	23782696
Pubmed	Tat predominantly associates with host promoter elements in HIV-1-infected T-cells - regulatory basis of transcriptional repression of c-Rel.	HOXA4 TRIM34	8.55e-05	15	32	2	25472883
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	FNBP4 ASXL1 VPS13A	1.14e-04	102	32	3	10231032
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	ARHGAP29 MAGI3 MACF1 TBC1D10A SWAP70	1.56e-04	565	32	5	25468996
Pubmed	Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.	MAGI2 MAGI3	2.43e-04	25	32	2	23873930
Pubmed	Alternatively spliced isoforms of WT1 control podocyte-specific gene expression.	MAGI2 PTPRO	3.05e-04	28	32	2	25993318
Pubmed	Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha.	MACF1 ASXL1	3.28e-04	29	32	2	18239623
Pubmed	Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.	MAGI2 MAGI3	4.52e-04	34	32	2	30726710
Pubmed	Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.	MAGI2 MAGI3	5.07e-04	36	32	2	26053890
Pubmed	Defining the molecular character of the developing and adult kidney podocyte.	MAGI2 PTPRO	5.95e-04	39	32	2	21931791
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	MAGI2 MAGI3 MACF1 GABBR2	6.30e-04	430	32	4	32581705
Pubmed	A gene expression resource generated by genome-wide lacZ profiling in the mouse.	ASXL1 TBC1D10A	7.57e-04	44	32	2	26398943
Interaction	PLXNB3 interactions	MAGI2 MAGI3 RIT2	2.39e-06	18	30	3	int:PLXNB3
Cytoband	11p15	TRIM34 SWAP70	4.18e-04	43	32	2	11p15
Cytoband	Ensembl 112 genes in cytogenetic band chr1p22	ARHGAP29 KYAT3	4.13e-03	137	32	2	chr1p22
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	TRIM34 SYT8 SWAP70	7.02e-03	564	32	3	chr11p15
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	MAGI2 MAGI3	2.36e-04	26	16	2	904
GeneFamily	PDZ domain containing	MAGI2 MAGI3	7.80e-03	152	16	2	1220
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_D\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	HOXA4 MAP9 TRIM34 GABBR2	3.19e-06	142	32	4	4ac3b285adfe80c47861943cf8c6188106cb3ba8
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRIQ1 SWAP70 TRPC4 RIT2	7.64e-06	177	32	4	64fbf799e7b0c4003b2f486cc41b0f7e7c11ea0c
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HOXA4 ARHGAP29 LRRIQ1 SYT8	8.71e-06	183	32	4	6f8f997ffc9eaebca2683de125b6069d07c07d26
Disease	Epileptic encephalopathy	MAGI2 GABBR2	4.56e-04	30	31	2	C0543888
Disease	cognitive decline measurement	ARHGAP29 MAGI3 TRIM34 GABBR2	1.61e-03	486	31	4	EFO_0007710
Disease	adverse effect, response to xenobiotic stimulus	MAGI2 RIT2	1.76e-03	59	31	2	EFO_0009658, GO_0009410
Disease	hemoglobin A1 measurement	MACF1 INAFM2 SWAP70 VPS13A	2.06e-03	520	31	4	EFO_0007629
Disease	Headache	MACF1 DDX10	2.07e-03	64	31	2	HP_0002315
Disease	acute lymphoblastic leukemia	MAGI2 RIT2	2.20e-03	66	31	2	EFO_0000220
Disease	thyroxine measurement	FNBP4 USP3	3.45e-03	83	31	2	EFO_0005130
Disease	upper face morphology measurement	MACF1 TRPC4	4.67e-03	97	31	2	EFO_0010949
Disease	Malignant neoplasm of breast	HOXA4 ARHGAP29 MACF1 TRPC4 DDX10	4.89e-03	1074	31	5	C0006142
Disease	HbA1c measurement	MACF1 INAFM2 SWAP70 VPS13A	5.23e-03	675	31	4	EFO_0004541
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	MAGI2 MACF1 RIT2	6.48e-03	364	31	3	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	loneliness measurement	FNBP4 MACF1	7.52e-03	124	31	2	EFO_0007865
Disease	C-reactive protein measurement	MACF1 NRBP2 USP3 THUMPD3 RIT2	7.93e-03	1206	31	5	EFO_0004458

Protein segments in the cluster

Peptide	Gene	Start	Entry
MKDKQKKKKERTWAE	ASXL1	1	Q8IXJ9
FSVVWCKPSKKKHKK	RAD54B	126	Q9Y620
KKTKKNHKAMNARAW	NRBP2	136	Q9NSY0
MSKSLKKKSHWTSKV	MAGI2	1	Q86UL8
MSKTLKKKKHWLSKV	MAGI3	1	Q5TCQ9
WKAMKEKEAKKIAAK	MAP9	476	Q49MG5
GMKLKWSKLKQDKVR	MTIF2	146	P46199
QEKKMQCKKHWKRFL	IRAK3	196	Q9Y616
KDVKKALKKILWKHI	OR5AP2	301	Q8NGF4
KRHCWMKQFKVEKKK	LRRIQ1	206	Q96JM4
KKTFTKWVNKHLMKV	MACF1	81	Q9UPN3
LHWMVVAEGKKKIKK	PTPRO	666	Q16827
MIAHKQKKTKKKRAW	ARHGAP29	1	Q52LW3
WRVHAIFKNVKMKKK	GABBR2	576	O75899
NRWKKKHSHRQNKKK	DDX10	21	Q13206
RRMKWKKDHKLPNTK	HOXA4	266	Q00056
KFVKWMTKHKKLSAI	KYAT3	396	Q6YP21
KKAKMAAKTNKKWVR	INAFM2	21	P0DMQ5
MLNQRKWKKRKTATK	SYT8	286	Q8NBV8
IWRLKKPKMVSKKLK	TRIM34	261	Q9BYJ4
AKKSKTKMPSLVKKW	FNBP4	936	Q8N3X1
WRKKHAAEMATAKKK	NKX6-1	291	P78426
MEKKLKRKDSLWKKL	RIT2	191	Q99578
MSKRKHKKKHMRWRS	NANOGNB	161	Q7Z5D8
KKKARWKPMSVKHTE	VPS13A	2561	Q96RL7
WDSKQKKMREKSKGK	SYCP2	781	Q9BX26
KWKKHQKKLKKQASL	TEX50	101	A0A1B0GTY4
KVWKINASFKKKKAK	THUMPD3	131	Q9BV44
HKCKKKQKSTKKFWI	USP3	386	Q9Y6I4
KKKLEMATNKTKSWK	SWAP70	521	Q9UH65
WMAKKHKKIRLRCQK	TBC1D10A	96	Q9BXI6
KWIWTHLCKKKMRRK	TRPC4	671	Q9UBN4