Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF7 NRIP1 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13 ARID5A	2.86e-09	55	83	7	GO:0042974
GeneOntologyMolecularFunction	nuclear receptor binding	MED24 PRAMEF7 NRIP1 PRAMEF14 ESR1 PRAMEF8 PRAMEF1 PRAMEF13 ARID5A	8.27e-08	187	83	9	GO:0016922
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	MED24 PRAMEF7 NRIP1 PRAMEF14 ESR1 MYOCD PRAMEF8 PRAMEF1 PRAMEF13 ARID5A	8.85e-06	417	83	10	GO:0061629
GeneOntologyMolecularFunction	amino acid sensor activity	SAR1B SAR1A	1.71e-05	2	83	2	GO:0140785
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	2.33e-05	82	83	5	GO:1990756
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	MED24 PRAMEF7 NRIP1 PRAMEF14 ESR1 MYOCD PRAMEF8 PRAMEF1 PRAMEF13 ARID5A RAD21	2.83e-05	582	83	11	GO:0140297
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	4.75e-05	95	83	5	GO:0140767
GeneOntologyMolecularFunction	activin receptor activity, type I	TGFBR1 ACVR1C	1.69e-04	5	83	2	GO:0016361
GeneOntologyMolecularFunction	transcription factor binding	MED24 PRAMEF7 NRIP1 PRAMEF14 ESR1 MYOCD PRAMEF8 PRAMEF1 PRAMEF13 ARID5A RAD21	2.77e-04	753	83	11	GO:0008134
GeneOntologyMolecularFunction	SMAD binding	TGFBR1 USP9X MYOCD ACVR1C	4.55e-04	86	83	4	GO:0046332
GeneOntologyMolecularFunction	activin receptor activity	TGFBR1 ACVR1C	6.03e-04	9	83	2	GO:0017002
GeneOntologyMolecularFunction	protein phosphatase 2A binding	ADRB2 MFHAS1 HMGCR	7.07e-04	42	83	3	GO:0051721
GeneOntologyMolecularFunction	activin binding	TGFBR1 ACVR1C	1.10e-03	12	83	2	GO:0048185
GeneOntologyMolecularFunction	molecular adaptor activity	MED24 PRAMEF7 NRIP1 ANAPC1 HIPK1 PRAMEF14 SEPTIN11 MYOCD RB1CC1 PRAMEF8 PRAMEF1 SEPTIN10 PRAMEF13 ARID5A	1.32e-03	1356	83	14	GO:0060090
GeneOntologyMolecularFunction	nuclear estrogen receptor binding	NRIP1 ESR1 ARID5A	1.40e-03	53	83	3	GO:0030331
GeneOntologyBiologicalProcess	somatic stem cell population maintenance	MED24 PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	4.54e-06	108	82	6	GO:0035019
GeneOntologyBiologicalProcess	blastocyst development	TGFBR1 PRAMEF7 PRAMEF14 ACVR1C PRAMEF8 PRAMEF1 PRAMEF13	7.24e-06	179	82	7	GO:0001824
GeneOntologyBiologicalProcess	blastocyst formation	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	1.48e-05	78	82	5	GO:0001825
GeneOntologyBiologicalProcess	regulation of ERK1 and ERK2 cascade	PRAMEF7 MFHAS1 PRAMEF14 ESR1 HMGCR PRAMEF8 PRAMEF1 PRAMEF13 EPHA7	2.21e-05	385	82	9	GO:0070372
GeneOntologyBiologicalProcess	female gamete generation	PRAMEF7 NRIP1 USP9X PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	3.00e-05	223	82	7	GO:0007292
GeneOntologyBiologicalProcess	ERK1 and ERK2 cascade	PRAMEF7 MFHAS1 PRAMEF14 ESR1 HMGCR PRAMEF8 PRAMEF1 PRAMEF13 EPHA7	4.20e-05	418	82	9	GO:0070371
GeneOntologyBiologicalProcess	oocyte development	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	4.69e-05	99	82	5	GO:0048599
GeneOntologyBiologicalProcess	oocyte differentiation	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	5.66e-05	103	82	5	GO:0009994
GeneOntologyBiologicalProcess	regulation of COPII vesicle coating	SAR1B SAR1A	1.55e-04	5	82	2	GO:0003400
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	1.49e-06	47	87	5	GO:0031462
GeneOntologyCellularComponent	activin receptor complex	TGFBR1 ACVR1C	2.54e-04	6	87	2	GO:0048179
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	PRAMEF7 ANAPC1 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	2.59e-04	212	87	6	GO:0031461
GeneOntologyCellularComponent	transferase complex	PRPSAP1 MED24 TGFBR1 PRAMEF7 CCNB3 ANAPC1 PRAMEF14 RB1CC1 ACVR1C PRAMEF8 PRAMEF1 PRAMEF13	6.26e-04	963	87	12	GO:1990234
GeneOntologyCellularComponent	ubiquitin ligase complex	MED24 PRAMEF7 ANAPC1 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	6.67e-04	352	87	7	GO:0000151
MousePheno	abnormal spermatogonia proliferation	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	2.45e-06	47	65	5	MP:0002685
MousePheno	abnormal jejunum morphology	PRAMEF7 PRAMEF8 PRAMEF1 PRAMEF13	3.79e-05	41	65	4	MP:0004002
MousePheno	abnormal circulating amylase level	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13 SLCO1B1	8.42e-05	156	65	6	MP:0008804
Domain	-	PRAMEF7 LRRC37A LRRC37A3 CEP72 MFHAS1 LRRC37A2 PPP1R37 SLITRK6 PRAMEF8 PRAMEF1 PRAMEF13	1.98e-07	321	84	11	3.80.10.10
Domain	L_dom-like	PRAMEF7 LRRC37A LRRC37A3 CEP72 MFHAS1 LRRC37A2 PPP1R37 SLITRK6 PRAMEF8 PRAMEF1 PRAMEF13	2.46e-07	328	84	11	IPR032675
Domain	LRRC37AB_C	LRRC37A LRRC37A3 LRRC37A2	3.50e-07	4	84	3	PF14914
Domain	LRRC37_N	LRRC37A LRRC37A3 LRRC37A2	3.50e-07	4	84	3	IPR032754
Domain	LRRC37AB_C	LRRC37A LRRC37A3 LRRC37A2	3.50e-07	4	84	3	IPR029423
Domain	LRRC37	LRRC37A LRRC37A3 LRRC37A2	3.50e-07	4	84	3	PF15779
Domain	LRRC37A/B-like	LRRC37A LRRC37A3 LRRC37A2	3.50e-07	4	84	3	IPR015753
Domain	PRAME_family	PRAMEF7 PRAMEF8 PRAMEF1 PRAMEF13	1.40e-06	19	84	4	IPR026271
Domain	Small_GTPase_SAR1	SAR1B SAR1A	2.00e-05	2	84	2	IPR006687
Domain	SAR1	SAR1B SAR1A	2.00e-05	2	84	2	PS51422
Domain	LRR	LRRC37A LRRC37A3 CEP72 MFHAS1 LRRC37A2 PPP1R37 SLITRK6	3.39e-05	201	84	7	PS51450
Domain	Leu-rich_rpt_typical-subtyp	LRRC37A LRRC37A3 CEP72 MFHAS1 LRRC37A2 SLITRK6	1.47e-04	177	84	6	IPR003591
Domain	LRR_TYP	LRRC37A LRRC37A3 CEP72 MFHAS1 LRRC37A2 SLITRK6	1.47e-04	177	84	6	SM00369
Domain	Leu-rich_rpt	LRRC37A LRRC37A3 CEP72 MFHAS1 LRRC37A2 PPP1R37 SLITRK6	2.19e-04	271	84	7	IPR001611
Domain	GS	TGFBR1 ACVR1C	4.14e-04	7	84	2	SM00467
Domain	GS_dom	TGFBR1 ACVR1C	4.14e-04	7	84	2	IPR003605
Domain	GS	TGFBR1 ACVR1C	4.14e-04	7	84	2	PS51256
Domain	TGF_beta_GS	TGFBR1 ACVR1C	4.14e-04	7	84	2	PF08515
Domain	LRR_1	LRRC37A LRRC37A3 CEP72 MFHAS1 LRRC37A2 SLITRK6	4.61e-04	219	84	6	PF00560
Domain	Calx_beta	FREM2 FREM3	5.50e-04	8	84	2	SM00237
Domain	Calx_beta	FREM2 FREM3	7.05e-04	9	84	2	IPR003644
Domain	Calx-beta	FREM2 FREM3	7.05e-04	9	84	2	PF03160
Domain	Activin_recp	TGFBR1 ACVR1C	8.79e-04	10	84	2	IPR000472
Domain	Activin_recp	TGFBR1 ACVR1C	8.79e-04	10	84	2	PF01064
Domain	LRR_8	LRRC37A LRRC37A3 MFHAS1 LRRC37A2 SLITRK6	1.05e-03	171	84	5	PF13855
Domain	TGFB_receptor	TGFBR1 ACVR1C	1.28e-03	12	84	2	IPR000333
Domain	Septin	SEPTIN11 SEPTIN10	1.51e-03	13	84	2	PF00735
Domain	G_SEPTIN_dom	SEPTIN11 SEPTIN10	1.51e-03	13	84	2	IPR030379
Domain	G_SEPTIN	SEPTIN11 SEPTIN10	1.51e-03	13	84	2	PS51719
Domain	Septin	SEPTIN11 SEPTIN10	1.76e-03	14	84	2	IPR016491
Domain	Kinase-like_dom	TGFBR1 ACAD11 HIPK1 SNRK ACVR1C MAST2 MAP3K2 EPHA7	3.01e-03	542	84	8	IPR011009
Domain	PROTEIN_KINASE_ATP	TGFBR1 HIPK1 SNRK ACVR1C MAST2 MAP3K2 EPHA7	4.61e-03	459	84	7	PS00107
Domain	Ser/Thr_kinase_AS	TGFBR1 HIPK1 SNRK ACVR1C MAST2 MAP3K2	5.44e-03	357	84	6	IPR008271
Domain	S_TKc	TGFBR1 HIPK1 SNRK ACVR1C MAST2 MAP3K2	5.59e-03	359	84	6	SM00220
Domain	PROTEIN_KINASE_ST	TGFBR1 HIPK1 SNRK ACVR1C MAST2 MAP3K2	5.82e-03	362	84	6	PS00108
Domain	Prot_kinase_dom	TGFBR1 HIPK1 SNRK ACVR1C MAST2 MAP3K2 EPHA7	6.46e-03	489	84	7	IPR000719
Domain	PROTEIN_KINASE_DOM	TGFBR1 HIPK1 SNRK ACVR1C MAST2 MAP3K2 EPHA7	6.75e-03	493	84	7	PS50011
Domain	Protein_kinase_ATP_BS	TGFBR1 HIPK1 SNRK ACVR1C MAP3K2 EPHA7	7.23e-03	379	84	6	IPR017441
Domain	Pkinase	TGFBR1 HIPK1 SNRK ACVR1C MAST2 MAP3K2	7.41e-03	381	84	6	PF00069
Domain	Arf	SAR1B SAR1A	8.54e-03	31	84	2	PF00025
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	7.28e-10	18	87	5	23894331
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	7.28e-10	18	87	5	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	7.28e-10	18	87	5	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	7.28e-10	18	87	5	14675769
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	9.86e-10	19	87	5	28604677
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	1.31e-09	20	87	5	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	1.31e-09	20	87	5	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	1.31e-09	20	87	5	21425410
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	2.22e-09	22	87	5	31729367
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	2.83e-09	23	87	5	19480014
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	4.45e-09	25	87	5	12620990
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	4.45e-09	25	87	5	37451217
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	5.50e-09	26	87	5	18500982
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	8.19e-09	28	87	5	25089626
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	1.18e-08	30	87	5	38786026
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	1.66e-08	32	87	5	37889087
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	2.67e-08	35	87	5	19389355
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A LRRC37A3 LRRC37A2	6.04e-08	4	87	3	22419166
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF7 PRAMEF8 PRAMEF1 PRAMEF13	8.48e-08	17	87	4	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF7 PRAMEF8 PRAMEF1 PRAMEF13	8.48e-08	17	87	4	37781892
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF7 PRAMEF8 PRAMEF1 PRAMEF13	1.09e-07	18	87	4	39181896
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	1.10e-07	46	87	5	17287250
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	1.69e-07	50	87	5	31806660
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	PRAMEF7 PRAMEF14 RB1CC1 PRAMEF8 PRAMEF1 MAST2 PRAMEF13 SAR1A EPHA7	3.34e-07	363	87	9	14691545
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	PRAMEF7 PRAMEF14 ESR1 PLA2G6 PRAMEF8 PRAMEF1 PRAMEF13 SAR1A	1.68e-06	326	87	8	17015433
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A LRRC37A3 LRRC37A2	1.79e-06	10	87	3	23064749
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	ACAD11 CEP72 ANAPC1 USP9X DOCK7 MAST2 PPP6R2 MAP3K2 RAD21	1.83e-06	446	87	9	24255178
Pubmed	Effects of statin treatments and polymorphisms in UGT1A1 and SLCO1B1 on serum bilirubin levels in Chinese patients with hypercholesterolaemia.	UGT1A1 SLCO1B1	6.19e-06	2	87	2	22749334
Pubmed	Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences.	ESR1 GREB1	6.19e-06	2	87	2	17463000
Pubmed	Irinotecan toxicity during treatment of metastatic colorectal cancer: focus on pharmacogenomics and personalized medicine.	UGT1A1 SLCO1B1	6.19e-06	2	87	2	30514181
Pubmed	Complex formation and function of estrogen receptor α in transcription requires RIP140.	NRIP1 ESR1	6.19e-06	2	87	2	25145671
Pubmed	Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.	SAR1B SAR1A	6.19e-06	2	87	2	38687799
Pubmed	Effect of genetic variants of bilirubin metabolism on the degree of hyperbilirubinemia in African-American newborns.	UGT1A1 SLCO1B1	6.19e-06	2	87	2	27977017
Pubmed	Polymorphisms in SLCO1B1 and UGT1A1 are associated with sorafenib-induced toxicity.	UGT1A1 SLCO1B1	6.19e-06	2	87	2	27533851
Pubmed	Silencing of mammalian Sar1 isoforms reveals COPII-independent protein sorting and transport.	SAR1B SAR1A	6.19e-06	2	87	2	23433038
Pubmed	The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.	SAR1B SAR1A	6.19e-06	2	87	2	24338480
Pubmed	Modulation of membrane rigidity by the human vesicle trafficking proteins Sar1A and Sar1B.	SAR1B SAR1A	6.19e-06	2	87	2	22974979
Pubmed	Risk factors for severe hyperbilirubinemia in neonates.	UGT1A1 SLCO1B1	6.19e-06	2	87	2	15319464
Pubmed	Amplification of WHSC1L1 regulates expression and estrogen-independent activation of ERα in SUM-44 breast cancer cells and is associated with ERα over-expression in breast cancer.	ESR1 NSD3	6.19e-06	2	87	2	27005559
Pubmed	Associations between UGT1A1 and SLCO1B1 polymorphisms and susceptibility to neonatal hyperbilirubinemia in Thai population.	UGT1A1 SLCO1B1	6.19e-06	2	87	2	35501760
Pubmed	Combined effects of the UGT1A1 and OATP2 gene polymorphisms as major risk factor for unconjugated hyperbilirubinemia in Indian neonates.	UGT1A1 SLCO1B1	6.19e-06	2	87	2	24865931
Pubmed	Long-range activation of GREB1 by estrogen receptor via three distal consensus estrogen-responsive elements in breast cancer cells.	ESR1 GREB1	6.19e-06	2	87	2	17666587
Pubmed	Gene Mutation in Neonatal Jaundice - Mutations in UGT1A1 and OATP2 Genes.	UGT1A1 SLCO1B1	6.19e-06	2	87	2	26960716
Pubmed	UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients.	UGT1A1 SLCO1B1	6.19e-06	2	87	2	19390945
Pubmed	Molecular analysis of SAR1-related cDNAs from a mouse pituitary cell line.	SAR1B SAR1A	6.19e-06	2	87	2	8262187
Pubmed	SAR1B senses leucine levels to regulate mTORC1 signalling.	SAR1B SAR1A	6.19e-06	2	87	2	34290409
Pubmed	Myocardin inhibits estrogen receptor alpha-mediated proliferation of human breast cancer MCF-7 cells via regulating MicroRNA expression.	ESR1 MYOCD	6.19e-06	2	87	2	27156566
Pubmed	Efficient and fast targeted production of murine models based on ENU mutagenesis.	TGFBR1 UNC45B GREB1	6.73e-06	15	87	3	16075367
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	TGFBR1 PRAMEF7 PRAMEF14 ACVR1C PRAMEF8 PRAMEF1 PRAMEF13 TARBP2	1.15e-05	424	87	8	21731673
Pubmed	ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.	PRAMEF7 PRAMEF8 PRAMEF1 PRAMEF13	1.40e-05	58	87	4	31598710
Pubmed	A genome-wide assessment of variability in human serum metabolism.	UGT1A1 ACAD11 SLCO1B1	1.42e-05	19	87	3	23281178
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	PRAMEF7 PRAMEF8 PRAMEF1 PRAMEF13	1.50e-05	59	87	4	11279525
Pubmed	Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.	TGFBR1 HMGCR ITGAL SLCO1B1	1.82e-05	62	87	4	20403997
Pubmed	Genetic link with cholelithiasis among pediatric SCA Tunisian patients: Examples of UGT1A1, SLCO1A2 and SLCO1B1.	UGT1A1 SLCO1B1	1.85e-05	3	87	2	26146896
Pubmed	Multiple Genetic Modifiers of Bilirubin Metabolism Involvement in Significant Neonatal Hyperbilirubinemia in Patients of Chinese Descent.	UGT1A1 SLCO1B1	1.85e-05	3	87	2	26146841
Pubmed	Small GTPases SAR1A and SAR1B regulate the trafficking of the cardiac sodium channel Nav1.5.	SAR1B SAR1A	1.85e-05	3	87	2	30251687
Pubmed	Complex multifactorial nature of significant hyperbilirubinemia in neonates.	UGT1A1 SLCO1B1	1.85e-05	3	87	2	19858149
Pubmed	Four and a half LIM domains 1 (FHL1) and receptor interacting protein of 140kDa (RIP140) interact and cooperate in estrogen signaling.	NRIP1 ESR1	1.85e-05	3	87	2	19401155
Pubmed	Human glutathione S-transferase P1-1 functions as an estrogen receptor α signaling modulator.	NRIP1 ESR1	1.85e-05	3	87	2	25218501
Pubmed	Association of neonatal hyperbilirubinemia in breast-fed infants with UGT1A1 or SLCOs polymorphisms.	UGT1A1 SLCO1B1	1.85e-05	3	87	2	25391605
Pubmed	Influence of common variants in the pharmacokinetic genes (OATP-C, UGT1A1, and MRP2) on serum bilirubin levels in healthy subjects.	UGT1A1 SLCO1B1	1.85e-05	3	87	2	15519273
Pubmed	The orphan nuclear receptor LRH-1 and ERα activate GREB1 expression to induce breast cancer cell proliferation.	ESR1 GREB1	1.85e-05	3	87	2	22359603
Pubmed	Aryl hydrocarbon receptor modulation of estrogen receptor α-mediated gene regulation by a multimeric chromatin complex involving the two receptors and the coregulator RIP140.	NRIP1 ESR1	1.85e-05	3	87	2	22071320
Pubmed	Genetic polymorphisms in Thai neonates with hyperbilirubinemia.	UGT1A1 SLCO1B1	1.85e-05	3	87	2	19397531
Pubmed	Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.	NRIP1 ESR1	1.85e-05	3	87	2	7641693
Pubmed	GREB1 is an estrogen receptor-regulated tumour promoter that is frequently expressed in ovarian cancer.	ESR1 GREB1	1.85e-05	3	87	2	29973689
Pubmed	Genetic Factors and Delayed TSB Monitoring and Treatment as Risk Factors Associated with Severe Hyperbilirubinemia in Term Neonates Admitted for Phototherapy.	UGT1A1 SLCO1B1	1.85e-05	3	87	2	32577754
Pubmed	Pharmacogenetic Analysis of OATP1B1, UGT1A1, and BCRP Variants in Relation to the Pharmacokinetics of Letermovir in Previously Conducted Clinical Studies.	UGT1A1 SLCO1B1	1.85e-05	3	87	2	31022310
Pubmed	Small sequence variations between two mammalian paralogs of the small GTPase SAR1 underlie functional differences in coat protein complex II assembly.	SAR1B SAR1A	1.85e-05	3	87	2	32358066
Pubmed	Coexpression of gene polymorphisms involved in bilirubin production and metabolism.	UGT1A1 SLCO1B1	1.85e-05	3	87	2	18558634
Pubmed	Expression of Fraser syndrome genes in normal and polycystic murine kidneys.	FREM2 FREM3	1.85e-05	3	87	2	21993971
Pubmed	[Role of genetic factors in occurrence of neonatal jaundice in Guangxi region].	UGT1A1 SLCO1B1	1.85e-05	3	87	2	16255851
Pubmed	Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients.	UGT1A1 KIF6 HMGCR SLCO1B1	2.34e-05	66	87	4	20679960
Pubmed	Genetic factors related to unconjugated hyperbilirubinemia amongst adults.	UGT1A1 SLCO1B1	3.70e-05	4	87	2	15864125
Pubmed	The FYVE domain of Smad Anchor for Receptor Activation (SARA) is required to prevent skin carcinogenesis, but not in mouse development.	SAR1B SAR1A	3.70e-05	4	87	2	25170969
Pubmed	Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex.	NRIP1 ESR1	3.70e-05	4	87	2	20200160
Pubmed	RIP-140 interacts with multiple nuclear receptors by means of two distinct sites.	NRIP1 ESR1	3.70e-05	4	87	2	8887632
Pubmed	Differential localization profile of Fras1/Frem proteins in epithelial basement membranes of newborn and adult mice.	FREM2 FREM3	3.70e-05	4	87	2	18563433
Pubmed	Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators.	NRIP1 ESR1	3.70e-05	4	87	2	23774759
Pubmed	Segmental and restricted localization pattern of Fras1 in the developing meningeal basement membrane in mouse.	FREM2 FREM3	3.70e-05	4	87	2	24101214
Pubmed	A signature motif in transcriptional co-activators mediates binding to nuclear receptors.	NRIP1 ESR1	3.70e-05	4	87	2	9192902
Pubmed	ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases.	NRIP1 ESR1	3.70e-05	4	87	2	17085477
Pubmed	Genetic Variations in Bilirubin Metabolism Genes and Their Association with Unconjugated Hyperbilirubinemia in Adults.	UGT1A1 SLCO1B1	3.70e-05	4	87	2	27943244
Pubmed	Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population.	UGT1A1 SLCO1B1	3.70e-05	4	87	2	19238116
Pubmed	Gender matters: estrogen receptor alpha (ERα) and histone deacetylase (HDAC) 1 and 2 control the gender-specific transcriptional regulation of human uridine diphosphate glucuronosyltransferases genes (UGT1A).	UGT1A1 ESR1	3.70e-05	4	87	2	23714156
Pubmed	Association of polymorphisms in four bilirubin metabolism genes with serum bilirubin in three Asian populations.	UGT1A1 SLCO1B1	3.70e-05	4	87	2	19243019
Pubmed	Estrogen pathway polymorphisms and mammographic density.	UGT1A1 ESR1	3.70e-05	4	87	2	22199302
Pubmed	Large-scale genotyping identifies 41 new loci associated with breast cancer risk.	NRIP1 HIPK1 ESR1 METAP1D	4.08e-05	76	87	4	23535729
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	PRAMEF7 PRAMEF14 SAR1B ASTE1 SLC25A30 PLA2G6 PRAMEF8 PRAMEF1 SEPTIN10 MAST2 PLXNB2 PRAMEF13	6.12e-05	1242	87	12	30973865
Pubmed	Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition.	UGT1A1 SLCO1B1	6.16e-05	5	87	2	20837016
Pubmed	Multilocus analyses of estrogen-related genes reveal involvement of the ESR1 gene in male infertility and the polygenic nature of the pathology.	NRIP1 ESR1	6.16e-05	5	87	2	16213843
Pubmed	Multilocus analyses reveal involvement of the ESR1, ESR2, and FSHR genes in migraine.	NRIP1 ESR1	6.16e-05	5	87	2	19093296
Pubmed	Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development.	FREM2 FREM3	6.16e-05	5	87	2	17251066
Pubmed	Additive effects of drug transporter genetic polymorphisms on irinotecan pharmacokinetics/pharmacodynamics in Japanese cancer patients.	UGT1A1 SLCO1B1	6.16e-05	5	87	2	19771428
Pubmed	Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population.	UGT1A1 SLCO1B1	6.16e-05	5	87	2	38279097
Pubmed	Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa.	FREM2 FREM3	6.16e-05	5	87	2	17596926
Pubmed	The expression of estrogen receptors as well as GREB1, c-MYC, and cyclin D1, estrogen-regulated genes implicated in proliferation, is increased in peritoneal endometriosis.	ESR1 GREB1	6.16e-05	5	87	2	22884659
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	ANAPC1 NPEPPS RB1CC1 PPP6R2 TARBP2	6.46e-05	167	87	5	25659891
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	UGT1A1 TGFBR1 ADRB2 MFHAS1 ESR1 ACVR1C	6.84e-05	275	87	6	20734064
Pubmed	Multigenic combination of estrogen-related genes is associated with age at natural menopause in a Spanish population.	NRIP1 ESR1	9.22e-05	6	87	2	19933466
Interaction	FRRS1 interactions	SAR1B NPHP4 SAR1A	1.29e-06	6	82	3	int:FRRS1
Cytoband	1p36.21	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	1.40e-07	63	87	5	1p36.21
Cytoband	3q22.1	ACAD11 ASTE1 COL6A5	7.15e-05	42	87	3	3q22.1
GeneFamily	PRAME family	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	8.80e-09	24	55	5	686
GeneFamily	Type 1 receptor serine/threonine kinases	TGFBR1 ACVR1C	1.89e-04	7	55	2	345
GeneFamily	Septins	SEPTIN11 SEPTIN10	6.94e-04	13	55	2	732
GeneFamily	Aminopeptidases\|CD molecules	NPEPPS METAP1D	1.20e-03	17	55	2	104
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	SAR1B SAR1A	3.99e-03	31	55	2	357
Coexpression	KINNEY_DNMT1_METHYLATION_TARGETS	PRAMEF7 PRAMEF8 PRAMEF1 PRAMEF13	4.87e-06	34	87	4	MM955
Coexpression	KOHOUTEK_CCNT2_TARGETS	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	7.54e-06	81	87	5	MM938
Coexpression	MORI_SMALL_PRE_BII_LYMPHOCYTE_UP	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	1.91e-05	98	87	5	MM592
Coexpression	DESCARTES_ORGANOGENESIS_SCHWANN_CELL_PRECURSOR	PRAMEF7 SLITRK6 PRAMEF8 PRAMEF1 PRAMEF13	1.91e-05	98	87	5	MM3656
Coexpression	HUANG_GATA2_TARGETS_DN	PRAMEF7 PRAMEF14 PRAMEF8 PRAMEF1 PRAMEF13	1.91e-05	98	87	5	MM942
Coexpression	BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS	MED24 PRAMEF7 MFHAS1 USP9X NPEPPS PRAMEF14 ESR1 PRAMEF8 PRAMEF1 PLXNB2 PRAMEF13 MAP3K2	3.02e-05	871	87	12	MM1005
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED	PRAMEF7 PRAMEF8 PRAMEF1 PRAMEF13	3.91e-05	57	87	4	MM1262
Coexpression	GSE29164_CD8_TCELL_VS_CD8_TCELL_AND_IL12_TREATED_MELANOMA_DAY7_UP	PRPSAP1 EDEM3 C2CD3 SEPTIN11 SLC25A30 SNRK	5.53e-05	200	87	6	M8500
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 OSBPL10 EVC SNRK SLCO1B1 EPHA7	1.50e-06	181	87	6	9d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 OSBPL10 EVC SNRK SLCO1B1 EPHA7	1.55e-06	182	87	6	eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	WDR91 MFHAS1 OSBPL10 SEPTIN11 EVC EPHA7	1.76e-06	186	87	6	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-CD1c+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	EXPH5 LRRC37A2 OSBPL10 SMPD2 CCDC168	1.51e-05	159	87	5	b3c52908cd24bbf851fac69db3850fc7f53c2092
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	WDR91 KIF6 OSBPL10 EVC EPHA7	1.76e-05	164	87	5	1cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCell	facs-Skin-Telogen-3m-Epithelial-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLIP4 ADRB2 ABCA12 EXPH5 SLITRK6	2.97e-05	183	87	5	26b18d1cc5d98f185176e100bafb9bc9081c66f7
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM2 PDE1C ABCA12 MYOCD EPHA7	3.05e-05	184	87	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM2 PDE1C ABCA12 MYOCD EPHA7	3.05e-05	184	87	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM2 PDE1C ABCA12 MYOCD EPHA7	3.05e-05	184	87	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	WDR91 MFHAS1 OSBPL10 SEPTIN11 EVC	3.30e-05	187	87	5	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EXPH5 OSBPL10 EVC SNRK EPHA7	3.30e-05	187	87	5	c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	USP9X NPEPPS HIPK1 RB1CC1 MAP3K2	3.38e-05	188	87	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	WDR91 MFHAS1 OSBPL10 EVC EPHA7	3.38e-05	188	87	5	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1C EXPH5 OSBPL10 EVC SNRK	3.56e-05	190	87	5	1cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1C EXPH5 OSBPL10 EVC SNRK	3.56e-05	190	87	5	59bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell	facs-Aorta-Heart-3m-Mesenchymal\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLIP4 DOCK7 EVC PLXNB2 EPHA7	3.74e-05	192	87	5	0dc1f46e40346ed0b286e53b106a812441575100
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDE1C BRINP3 UNC45B MYOCD EPHA7	4.33e-05	198	87	5	22e766df1276c5b14aa0d83f434f47140ebb98ea
Disease	alkaline phosphatase measurement	TTC7A MED24 WDR91 EDEM3 MFHAS1 PPP1R37 EVC PLA2G6 ACVR1C PKD1L3 PPP6R2 ST8SIA3 SLCO1B1	3.26e-06	1015	80	13	EFO_0004533
Disease	bilirubin metabolic disorder (implicated_via_orthology)	UGT1A1 SLCO1B1	7.22e-05	5	80	2	DOID:2741 (implicated_via_orthology)
Disease	bilirubin metabolic disorder (is_implicated_in)	UGT1A1 SLCO1B1	1.08e-04	6	80	2	DOID:2741 (is_implicated_in)
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	COPB1 MFHAS1 NPEPPS DOCK7 PLA2G6 HMGCR	1.42e-04	291	80	6	EFO_0008317, EFO_0020946
Disease	myocardial infarction (is_implicated_in)	KIF6 BRINP3 ADRB2 ESR1	1.55e-04	99	80	4	DOID:5844 (is_implicated_in)
Disease	coronary artery disease (is_implicated_in)	KIF6 BRINP3 ESR1 HMGCR	1.61e-04	100	80	4	DOID:3393 (is_implicated_in)
Disease	plexin-B2 measurement	PPP6R2 PLXNB2	2.58e-04	9	80	2	EFO_0021867
Disease	Polydactyly	FREM2 C2CD3 USP9X EVC	2.94e-04	117	80	4	C0152427
Disease	vitamin D measurement	NRIP1 COPB1 DOCK7 MAST2 PPP6R2 SLCO1B1	3.09e-04	336	80	6	EFO_0004631
Disease	Uterine leiomyoma, estrogen-receptor negative breast cancer	EXPH5 ESR1	3.22e-04	10	80	2	EFO_1000650, HP_0000131
Disease	X-21796 measurement	UGT1A1 SLCO1B1	3.93e-04	11	80	2	EFO_0800825
Disease	biliverdin measurement	UGT1A1 SLCO1B1	4.71e-04	12	80	2	EFO_0021033
Disease	myeloid leukemia (is_implicated_in)	UGT1A1 NSD3	5.55e-04	13	80	2	DOID:8692 (is_implicated_in)
Disease	taurolithocholate 3-sulfate measurement	ESR1 SLCO1B1	5.55e-04	13	80	2	EFO_0021036
Disease	glucose measurement	EDEM3 ADRB2 LRRC37A LRRC37A3 NPEPPS ACVR1C	5.91e-04	380	80	6	EFO_0004468
Disease	smooth surface dental caries	PDE1C KIF6 ITGAL	6.47e-04	62	80	3	EFO_0006339
Disease	tonsillectomy risk measurement	ANAPC1 PKD1L3 ITGAL PPP6R2 SLCO1B1	7.17e-04	260	80	5	EFO_0007924
Disease	brain connectivity measurement	KIF6 MFHAS1 NPEPPS LRRC37A2 MAST2 EPHA7	7.72e-04	400	80	6	EFO_0005210
Disease	low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	MFHAS1 DOCK7 HMGCR SLCO1B1	8.09e-04	153	80	4	EFO_0004611, EFO_0020944
Disease	Endometrial Carcinoma	NRIP1 ESR1 RAD21	1.00e-03	72	80	3	C0476089
Disease	fatty acid measurement	PDE1C MFHAS1 DOCK7 HMGCR PPP6R2 SLCO1B1	1.20e-03	436	80	6	EFO_0005110
Disease	cardiac troponin I measurement	PDE1C HABP2 GREB1 PLXNB2	1.36e-03	176	80	4	EFO_0010071
Disease	BREAST CANCER	ESR1 RB1CC1	1.47e-03	21	80	2	114480
Disease	Drug toxicity	UGT1A1 SLCO1B1 EPHA7	1.56e-03	84	80	3	C0013221
Disease	Adverse reaction to drug	UGT1A1 SLCO1B1 EPHA7	1.56e-03	84	80	3	C0041755
Disease	Parkinson disease	SNCAIP PLA2G6	1.62e-03	22	80	2	cv:C0030567
Disease	free cholesterol:total lipids ratio, intermediate density lipoprotein measurement	MFHAS1 DOCK7 HMGCR	1.67e-03	86	80	3	EFO_0008595, EFO_0020945
Disease	female reproductive system disease	PDE1C GREB1	1.77e-03	23	80	2	EFO_0009549
Disease	lipid measurement, lipoprotein measurement	DOCK7 HMGCR PPP6R2	1.90e-03	90	80	3	EFO_0004529, EFO_0004732
Disease	Lynch syndrome (is_implicated_in)	TGFBR1 ASTE1	1.93e-03	24	80	2	DOID:3883 (is_implicated_in)
Disease	sleep duration, low density lipoprotein cholesterol measurement	DOCK7 HMGCR PKD1L3	1.96e-03	91	80	3	EFO_0004611, EFO_0005271
Disease	apolipoprotein B measurement	NPEPPS DOCK7 PPP1R37 HMGCR ACVR1C PKD1L3 PPP6R2	2.16e-03	663	80	7	EFO_0004615
Disease	Myocardial Infarction	NRIP1 KIF6 ESR1	2.22e-03	95	80	3	C0027051
Disease	Malignant tumor of breast	ESR1 RB1CC1	2.44e-03	27	80	2	cv:C0006142
Disease	Breast neoplasm	ESR1 RB1CC1	2.44e-03	27	80	2	cv:C1458155
Disease	Familial cancer of breast	ESR1 RB1CC1	2.44e-03	27	80	2	cv:C0346153
Disease	gastroesophageal reflux disease	NRIP1 PDE1C SNRK	2.64e-03	101	80	3	EFO_0003948

Protein segments in the cluster

Peptide	Gene	Start	Entry
KYKSSLVHMILGLSL	BRINP3	541	Q76B58
LKEHKALKTLGIIMG	ADRB2	266	P07550
THGIMSPLAKKKLLA	ARID5A	251	Q03989
LHDLKGTMSLTFLLG	ADGRG4	2936	Q8IZF6
ASGTHPLLDKMRSLK	ABCA12	681	Q86UK0
GMIKLALSIASGLAH	ACVR1C	291	Q8NER5
LGHSLMSLTGLKSLD	CEP72	46	Q9P209
HVTGKAMLTSLGLKL	CLIP4	271	Q8N3C7
KLHHLQSLLLTMLVG	ASTE1	481	Q2TB18
LLTLKAAHSMDTLGS	ACAD11	686	Q709F0
ATQGTMSHLKKPLIL	CCNB3	496	Q8WWL7
SPKVKMALRTSGHLL	RAD21	46	O60216
LMALGLNGHLTKLAT	ANAPC1	1176	Q9H1A4
KLKLTHLGTAVSVMA	RB1CC1	186	Q8TDY2
KLVSRTGHLMKLLSG	LRRC37A3	1516	O60309
HVLLLAGKSLKVDMT	METAP1D	106	Q6UB28
KLISRTGHLMKLLSG	LRRC37A2	1516	A6NM11
KLISRTGHLMKLLSG	LRRC37A	1516	A6NMS7
HSGVLLELGLKKEHM	GREB1	716	Q4ZG55
KLLLMGHKAAGKTLL	MFHAS1	411	Q9Y4C4
TALMKLKSLGLIHAD	HIPK1	301	Q86Z02
LSLMAALAAGHLVKS	HMGCR	851	P04035
ILKKMGVSLIHLKDG	EDEM3	591	Q9BZQ6
ATGHLGFMITSKILK	FREM2	1671	Q5SZK8
KGSSLHVGSDLLKFM	PLXNB2	696	O15031
KITDTLIHLMAKAGL	ESR1	481	P03372
AIEKPKALSLMLHTA	PDE1C	361	Q14123
MLLMATILHLGKSSL	COPB1	586	P53618
HMKSLKILLVINGST	MAP3K2	111	Q9Y2U5
ILGKRSSLLHKKIGM	KIF6	536	Q6ZMV9
SGMLHLKKARLLQSS	NRIP1	76	P48552
GKKLQSETLHTSLML	EXPH5	1386	Q8NEV8
LSTHVLGKEKIASML	MSANTD3	101	Q96H12
LGITLVGHQKKIMSS	EPHA7	966	Q15375
MTLLGSEHSLLIRSK	MYOCD	1	Q8IZQ8
SLLLIGSAAVQMKHL	NPHP4	756	O75161
TTGLKMKHLLTGQER	PTPN21	1041	Q16825
IKTGGLMALSLALKV	PPP1R37	401	O75864
KAVGLLVLHLSGMVL	SMPD2	116	O60906
SDLHVLLLMALVGKT	HABP2	6	Q14520
TKKHLILSGLMGDTV	SLC25A30	186	Q5SVS4
KILQSMAILGKATSH	CCDC125	146	Q86Z20
GTTKESALLLHVLLM	C2CD3	796	Q4AC94
ESILGGVLKVLLHSM	DOCK7	1501	Q96N67
THLTIGMRELGKKLS	COL6A5	1361	A8TX70
HRAKASLAGTLSLML	MS4A6E	111	Q96DS6
LLITSMGHIKLTDFG	MAST2	641	Q6P0Q8
GSIVCKLLASMLAKA	PRPSAP1	111	Q14558
KLLASMLAKAGLTHI	PRPSAP1	116	Q14558
LATLTQMRLSGKKHL	EVC	656	P57679
DKKTTAHLSLQMLPG	CCDC168	5871	Q8NDH2
LGSLMKSPHLESLKS	PRAMEF8	66	Q5VWM4
LAMLTAHRAGKKHLS	SCNM1	56	Q9BWG6
VLKHGDGTTLDIMLK	NPEPPS	751	P55786
SLVLKHIGTSALMDL	PPP6R2	151	O75170
LGSLMKTLHLETLKA	PRAMEF13	66	Q5VWM6
MGALKDLLRHTSGLS	PRAMEF13	391	Q5VWM6
VTIPKMLANHLLGSK	OR1A1	76	Q9P1Q5
TGHMGFLITSKSLKA	FREM3	1676	P0C091
AHLSKPMEKLLGLAG	MRPS16	81	Q9Y3D3
LKALGHPAMLSKVLG	USP9X	1701	Q93008
NHLTKLSKGMFLGLH	SLITRK6	421	Q9H5Y7
PTGHSLKSLDLVTMK	SEPTIN11	156	Q9NVA2
LGSLMKTLHLETLKA	PRAMEF14	66	Q5SWL7
KSLSMVTANKLLHLL	HID1	496	Q8IV36
LGVLGHMLSGKSLDL	MED24	436	O75448
HMLSGKSLDLLLAAA	MED24	441	O75448
SFILLGLDMKSISLH	PKD1L3	1511	Q7Z443
NKHLSPKRLSTGILM	ST8SIA3	291	O43173
SLHLMIKKHTLASGG	SNCAIP	716	Q9Y6H5
LGLDNAGKTTLLHML	SAR1A	31	Q9NR31
LGSLMKTLHLETLKA	PRAMEF1	66	O95521
GGILALAILHSKSMA	PLA2G6	521	O60733
LKHVKHMLLLTNTFG	ITGAL	221	P20701
ILITILKMHSTKGRH	OR5P3	221	Q8WZ94
SLKLMSLCLGSQLHG	SNRK	646	Q9NRH2
LHLISQLKLGMDLTK	OSBPL10	401	Q9BXB5
KTLGAIIMKSSIIHI	SLCO1B1	41	Q9Y6L6
GMIKLALSTASGLAH	TGFBR1	301	P36897
LGSLMKSPHLESLKS	PRAMEF7	66	Q5VXH5
LIALLAHAKMLGLTV	PTRH2	126	Q9Y3E5
GALAMLTAAHKKLCL	UNC45B	826	Q8IWX7
LLMLHGQKLKSRAGT	PWP2	826	Q15269
IKKDSAMLLSGCSHL	UGT1A1	116	P22309
PTGHSLKTLDLLTMK	SEPTIN10	181	Q9P0V9
RKSLPASITMHKGSL	NSD3	476	Q9BZ95
VMAAKHLAGVLLHSL	TTC7A	281	Q9ULT0
GLMLSRLGHKSLAQK	TTC7A	786	Q9ULT0
ALKHLKGGSMLEPAL	TARBP2	91	Q15633
LGLDNAGKTTLLHML	SAR1B	31	Q9Y6B6
ASMDGKIKLTTLLAH	WDR91	731	A4D1P6