Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	Golgi to endosome transport	VPS13C AP2A1 VPS13A DOP1A DOP1B	2.36e-07	18	164	5	GO:0006895
GeneOntologyBiologicalProcess	gonadal mesoderm development	TSPY3 TSPY2 TSPY8 TSPY10	4.71e-07	9	164	4	GO:0007506
GeneOntologyBiologicalProcess	epithelial cell development	ATRX PODXL ESR1 GPX1 VSIG1 E2F4 DICER1 PTPRS ATF4 SLC4A5	6.07e-05	269	164	10	GO:0002064
GeneOntologyBiologicalProcess	mitotic sister chromatid cohesion, telomeric	ATRX TNKS	6.28e-05	2	164	2	GO:0099404
GeneOntologyBiologicalProcess	maintenance of mitotic sister chromatid cohesion, telomeric	ATRX TNKS	6.28e-05	2	164	2	GO:0099403
GeneOntologyBiologicalProcess	negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric	ATRX TNKS	6.28e-05	2	164	2	GO:1904908
GeneOntologyBiologicalProcess	regulation of maintenance of mitotic sister chromatid cohesion, telomeric	ATRX TNKS	6.28e-05	2	164	2	GO:1904907
GeneOntologyBiologicalProcess	chromatin remodeling	ATRX ACTR5 ESR1 GPX1 TSPY3 TSPY2 TSPY8 SRCAP DICER1 TASOR2 KMT2D SF3B1 TSPY10 TAF1 SPOCD1 KAT14 DNMT3L	8.95e-05	741	164	17	GO:0006338
GeneOntologyBiologicalProcess	spermatogenesis	CFAP47 BCL2L10 ATRX KCTD19 BTBD18 TSPY3 TSPY2 TSPY8 NR6A1 DICER1 ZFP37 TSPY10 HSF2 SPOCD1 AFF4 DNMT3L IQCG	9.40e-05	744	164	17	GO:0007283
GeneOntologyBiologicalProcess	male gamete generation	CFAP47 BCL2L10 ATRX KCTD19 BTBD18 TSPY3 TSPY2 TSPY8 NR6A1 DICER1 ZFP37 TSPY10 HSF2 SPOCD1 AFF4 DNMT3L IQCG	1.25e-04	762	164	17	GO:0048232
GeneOntologyBiologicalProcess	protein-DNA complex organization	CAND1 ATRX ACTR5 ESR1 GPX1 TSPY3 TSPY2 TSPY8 SRCAP DICER1 TASOR2 GTF2E1 KMT2D KANSL2 SF3B1 TSPY10 TAF1 SPOCD1 KAT14 DNMT3L	1.36e-04	999	164	20	GO:0071824
GeneOntologyBiologicalProcess	post-embryonic forelimb morphogenesis	ATRX ENPP1	1.88e-04	3	164	2	GO:0035128
GeneOntologyBiologicalProcess	negative regulation of maintenance of sister chromatid cohesion	ATRX TNKS	1.88e-04	3	164	2	GO:0034092
GeneOntologyBiologicalProcess	negative regulation of maintenance of mitotic sister chromatid cohesion	ATRX TNKS	1.88e-04	3	164	2	GO:0034183
GeneOntologyCellularComponent	chromatin	NELFE ATRX ACTR5 ESR1 CALCOCO1 HDX ZBTB8B ETS1 TSPY3 TSPY2 E2F4 E2F5 TSPY8 NR6A1 DBP SRCAP CREB3L1 CITED2 PPP1R10 KANSL2 SF3B1 MITF TSPY10 ATF4 TAF1 HSF2 KAT14 AFF4 DNMT3L	3.22e-06	1480	162	29	GO:0000785
GeneOntologyCellularComponent	costamere	ANK2 TRPC1 CMYA5 AHNAK2	2.28e-05	22	162	4	GO:0043034
GeneOntologyCellularComponent	vesicle coat	COPB1 SEC24A ENTHD1 AP2A1 SEC24B	1.72e-04	67	162	5	GO:0030120
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	LPCAT1 ATP6V0A1 SGSM1 COPB1 VPS13C SEC24A TOM1 TMEM63B WASHC3 ENTHD1 ABCA7 C2CD5 AP2A1 PIK3C3 PTPRS SEC24B VPS13A SNX9 ULK2 AHNAK2 DOP1B MVB12B	4.90e-04	1307	162	22	GO:0030659
GeneOntologyCellularComponent	coated vesicle	ATP6V0A1 COPB1 SEC24A ENTHD1 ECPAS F5 AP2A1 SEC24B RNF216 SNX9	5.18e-04	360	162	10	GO:0030135
GeneOntologyCellularComponent	postsynaptic density, intracellular component	DLGAP1 DICER1 SHANK3 GRID2IP	5.61e-04	49	162	4	GO:0099092
GeneOntologyCellularComponent	vesicle membrane	LPCAT1 ATP6V0A1 SGSM1 COPB1 VPS13C SEC24A TOM1 TMEM63B WASHC3 ENTHD1 ABCA7 C2CD5 AP2A1 PIK3C3 PTPRS SEC24B VPS13A SNX9 ULK2 AHNAK2 DOP1B MVB12B	5.89e-04	1325	162	22	GO:0012506
GeneOntologyCellularComponent	super elongation complex	EAF2 AFF4	8.77e-04	6	162	2	GO:0032783
GeneOntologyCellularComponent	postsynaptic specialization, intracellular component	DLGAP1 DICER1 SHANK3 GRID2IP	9.33e-04	56	162	4	GO:0099091
Domain	Dopey_N	DOP1A DOP1B	7.48e-05	2	162	2	PF04118
Domain	Dopey_N	DOP1A DOP1B	7.48e-05	2	162	2	IPR007249
Domain	ARM-like	CAND1 COPB1 FRYL ECPAS SF3B1 AP2A1 STKLD1 PPP6R2 GPRASP2 KPNA2	1.27e-04	270	162	10	IPR011989
Domain	ARM-type_fold	CAND1 COPB1 FRYL ECPAS SF3B1 AP2A1 PIK3C3 STKLD1 PPP6R2 GPRASP2 KPNA2	1.87e-04	339	162	11	IPR016024
Domain	CD34_antigen	PODXL PODXL2	2.23e-04	3	162	2	PF06365
Domain	CD34/Podocalyxin	PODXL PODXL2	2.23e-04	3	162	2	IPR013836
Domain	VPS13	VPS13C VPS13A	2.23e-04	3	162	2	IPR026847
Domain	VPS13_mid_rpt	VPS13C VPS13A	2.23e-04	3	162	2	PF16910
Domain	VPS13	VPS13C VPS13A	2.23e-04	3	162	2	PF16908
Domain	VPS13_N2	VPS13C VPS13A	2.23e-04	3	162	2	IPR031646
Domain	VPS13_mid_rpt	VPS13C VPS13A	2.23e-04	3	162	2	IPR031642
Domain	NAP_family	TSPY2 TSPY8 TSPY10	3.98e-04	17	162	3	IPR002164
Domain	NAP	TSPY2 TSPY8 TSPY10	3.98e-04	17	162	3	PF00956
Domain	SHR-BD	VPS13C VPS13A	4.44e-04	4	162	2	IPR009543
Domain	ADD	ATRX DNMT3L	4.44e-04	4	162	2	IPR025766
Domain	VPS13_C	VPS13C VPS13A	4.44e-04	4	162	2	PF16909
Domain	VPS13_C	VPS13C VPS13A	4.44e-04	4	162	2	IPR031645
Domain	ADD	ATRX DNMT3L	4.44e-04	4	162	2	PS51533
Domain	SHR-BD	VPS13C VPS13A	4.44e-04	4	162	2	PF06650
Domain	NUT	NUTM2G NUTM2F	7.35e-04	5	162	2	IPR024310
Domain	NUT_N	NUTM2G NUTM2F	7.35e-04	5	162	2	IPR024309
Domain	NUT	NUTM2G NUTM2F	7.35e-04	5	162	2	PF12881
Domain	Autophagy-rel_C	VPS13C VPS13A	7.35e-04	5	162	2	IPR015412
Domain	ATG_C	VPS13C VPS13A	7.35e-04	5	162	2	PF09333
Domain	Sec23/24_helical_dom	SEC24A SEC24B	1.10e-03	6	162	2	IPR006900
Domain	E2F_CC-MB	E2F4 E2F5	1.10e-03	6	162	2	IPR032198
Domain	Sec23_24_beta_S	SEC24A SEC24B	1.10e-03	6	162	2	IPR012990
Domain	zf-Sec23_Sec24	SEC24A SEC24B	1.10e-03	6	162	2	PF04810
Domain	Sec23_trunk	SEC24A SEC24B	1.10e-03	6	162	2	PF04811
Domain	Sec23_helical	SEC24A SEC24B	1.10e-03	6	162	2	PF04815
Domain	Sec23_BS	SEC24A SEC24B	1.10e-03	6	162	2	PF08033
Domain	E2F_CC-MB	E2F4 E2F5	1.10e-03	6	162	2	PF16421
Domain	Sec23/24_trunk_dom	SEC24A SEC24B	1.10e-03	6	162	2	IPR006896
Domain	Znf_Sec23_Sec24	SEC24A SEC24B	1.10e-03	6	162	2	IPR006895
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	SGSM1 CAND1 ATRX UBE4B MAP4 EPB41L4B VPS13C SPTB CALCOCO1 TOM1 CAMSAP3 CAST TMEM63B RNF213 WASHC3 FRYL ADGRV1 STK32C ECPAS TASOR2 MAPK8IP3 PIK3C3 PTPRS SNX9 SLC4A5 AFF4 FRMD3 DOP1A	4.65e-10	1489	165	28	28611215
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DLGAP1 EGLN2 ATP6V0A1 CAND1 ANK2 ATRX COPB1 UBE4B SPTB NCAPH2 CMYA5 ST13 MAPK8IP3 KANSL2 SF3B1 SEPTIN3 AP2A1 SACS RNF216 TNKS TAF1 GPRASP2 AFF4 DOP1B	1.07e-08	1285	165	24	35914814
Pubmed	DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NFκB complex in the (de-)methylation of TRAF1.	ESR1 ETS1 E2F4 E2F5 NR6A1 ATF4 DNMT3L	6.56e-08	74	165	7	24952347
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DLGAP1 ATP6V0A1 CAND1 ANK2 COPB1 MAP4 EPB41L4B SPTB CALCOCO1 TOM1 CAMSAP3 PSMD3 SCRN1 ST13 SHANK3 MAPK8IP3 SF3B1 AP2A1 SACS PTPRS VCAN ALB PPP6R2 ST13P5	8.08e-08	1431	165	24	37142655
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	NELFE CAND1 ACTR5 LRRC40 SRCAP ECPAS GTF2E1 RPAP1 KHDRBS3 TAF1 AFF4 KPNA2	4.04e-07	390	165	12	17643375
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DLGAP1 AGAP5 CAND1 ANK2 UBE4B CAMSAP3 SHANK3 AP2A1 SACS PHACTR1	1.05e-06	281	165	10	28706196
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	LPCAT1 CAND1 ANK2 COPB1 MAP4 SEC24A TOM1 ECPAS PPP1R10 SEC24B SNX9 GPRASP2	1.76e-06	449	165	12	31732153
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	NELFE FAM193B CAND1 ANK2 ATRX COPB1 MAP4 CAST SRCAP PPP1R10 GTF2E1 SF3B1 SEC24B SNX9 PPP6R2 AFF4 AHNAK2	2.47e-06	934	165	17	33916271
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	RALGDS ATRX EPB41L4B LONP2 ENPP1 CAMSAP3 GMIP DICER1 LPIN1 FREM2 RPAP1 RNF216 TNFAIP2 PPP6R2	2.99e-06	650	165	14	38777146
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DLGAP1 CAND1 ANK2 PDE1B CALCOCO1 CAMSAP3 SHANK3 MAPK8IP3 SF3B1 SEPTIN3 AP2A1 PTPRS TNKS PPP6R2 CDH11 AFF4 PHACTR1	3.71e-06	963	165	17	28671696
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	ATRX MAP4 CAST RNF213 NCAPH2 SRCAP SF3B1 TAF1 AHNAK2 KPNA2	4.64e-06	332	165	10	32786267
Pubmed	Canonical and atypical E2Fs regulate the mammalian endocycle.	E2F4 E2F5 ALB	5.77e-06	8	165	3	23064266
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	DLGAP1 ATP6V0A1 ANK2 MAP4 CAMSAP3 C2CD5 MAPK8IP3 AP2A1 SACS PPP6R2	6.84e-06	347	165	10	17114649
Pubmed	Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme.	KMT2D PCDH15 KLHL18	8.63e-06	9	165	3	35296311
Pubmed	Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.	E2F4 E2F5 KMT2D	8.63e-06	9	165	3	16951254
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	NELFE ATRX MAP4 ST13 PPP1R10 GTF2E1 SF3B1 TAF1 AFF4	9.11e-06	283	165	9	30585729
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	FAM193B ATRX PODXL ESR1 MUC16 RNF213 STK32C FREM2 KMT2D SF3B1 VPS13A TAF1	1.42e-05	552	165	12	10737800
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	ATP6V0A1 MAP4 SEC24A CAMSAP3 WASHC3 ABCA7 SEC24B BCL10 SPINDOC AHNAK2	1.43e-05	378	165	10	34315543
Pubmed	Large-scale concatenation cDNA sequencing.	LPCAT1 ANK2 MAP4 DBP ECPAS DICER1 CREB3L1 SF3B1 PIK3C3 VPS13A TNKS FTO	1.88e-05	568	165	12	9110174
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	CAND1 COPB1 UBE4B MAP4 SEC24A TOM1 GPX1 CAST ISOC1 PSMD3 SCRN1 FRYL CMYA5 ECPAS ST13 GTF2E1 UBXN7 FTO AHNAK2 KPNA2	2.03e-05	1455	165	20	22863883
Pubmed	A "double adaptor" method for improved shotgun library construction.	LPCAT1 ANK2 MAP4 DBP ECPAS DICER1 CREB3L1 SF3B1 PIK3C3 VPS13A TNKS FTO	2.09e-05	574	165	12	8619474
Pubmed	An inter-species protein-protein interaction network across vast evolutionary distance.	FAM193B TRIM41 CALCOCO1 WASHC3 NCAPH2 CREB3L1 TASOR2 KHDRBS3 ATF4 SNX9 GPRASP2	2.14e-05	483	165	11	27107014
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ANKRD13D FAM193B UBE4B FRYL STK32C SRCAP ABCA7 MAPK8IP3 TBC1D16 KMT2D RPAP1 AP2A1 PTPRS TNFAIP2 ULK2 AHNAK2 MVB12B	2.20e-05	1105	165	17	35748872
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	CAND1 COPB1 EPB41L4B PODXL VPS13C SEC24A MUC16 RNF213 PODXL2 TASOR2 SF3B1 SEC24B VPS13A ALB	2.22e-05	777	165	14	35844135
Pubmed	ENPP1 and ESR1 genotypes associated with subclassifications of craniofacial asymmetry and severity of temporomandibular disorders.	ENPP1 ESR1	2.24e-05	2	165	2	29103441
Pubmed	Synapse structure: glutamate receptors connected by the shanks.	DLGAP1 SHANK3	2.24e-05	2	165	2	10574750
Pubmed	Estrogen receptor α enhances the transcriptional activity of ETS-1 and promotes the proliferation, migration and invasion of neuroblastoma cell in a ligand dependent manner.	ESR1 ETS1	2.24e-05	2	165	2	26122040
Pubmed	E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control.	E2F4 E2F5	2.24e-05	2	165	2	11030352
Pubmed	Glucose availability controls ATF4-mediated MITF suppression to drive melanoma cell growth.	MITF ATF4	2.24e-05	2	165	2	28380427
Pubmed	Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans.	DOP1A DOP1B	2.24e-05	2	165	2	10931277
Pubmed	ENPP1 and ESR1 genotypes influence temporomandibular disorders development and surgical treatment response in dentofacial deformities.	ENPP1 ESR1	2.24e-05	2	165	2	27519661
Pubmed	St13 protects against disordered acinar cell arachidonic acid pathway in chronic pancreatitis.	ST13 ST13P5	2.24e-05	2	165	2	35562743
Pubmed	Brain-specific transcript variants of 5' and 3' ends of mouse VPS13A and VPS13C.	VPS13C VPS13A	2.24e-05	2	165	2	17196930
Pubmed	The ESR1 and GPX1 gene expression level in human malignant and non-malignant breast tissues.	ESR1 GPX1	2.24e-05	2	165	2	29543921
Pubmed	Transcription factor Ets1 cooperates with estrogen receptor α to stimulate estradiol-dependent growth in breast cancer cells and tumors.	ESR1 ETS1	2.24e-05	2	165	2	23874775
Pubmed	Lineage-specific transcriptional regulation of DICER by MITF in melanocytes.	DICER1 MITF	2.24e-05	2	165	2	20550935
Pubmed	Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas.	DICER1 KMT2D	2.24e-05	2	165	2	26841698
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	DLGAP1 PDE1B UBE4B MAP4 GMIP RPAP1 UBXN7 PPP6R2	2.47e-05	246	165	8	15345747
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CAND1 COPB1 MAP4 PSMD3 LRRC40 SRCAP F5 DICER1 PPP1R10 SF3B1 RPAP1 AP2A1 SACS ALB SNX9 KPNA2	3.22e-05	1024	165	16	24711643
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	CAND1 COPB1 LONP2 GPX1 HDX CAMSAP3 PSMD3 GMIP ECPAS ST13 PPP1R10 AP2A1 TNKS SNX9 KPNA2	3.38e-05	916	165	15	32203420
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ESR1 ZBTB8B ETS1 E2F4 E2F5 NR6A1 SRCAP ZNF623 ZFP37 CITED2 PPP1R10 GTF2E1 ATF4 DOP1B	3.40e-05	808	165	14	20412781
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	DLGAP1 ENPP1 ESR1 SPTB PYROXD2 ETS1 SCRN1 ADGRV1 CITED2 GTF2E1 SUSD1 PIK3C3 UBXN7 MVB12B	3.68e-05	814	165	14	23251661
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	EAF2 COPB1 SEC24A TOM1 APBA3 GMIP LPIN1 RPAP1 AP2A1 YAE1 SEC24B MITF RNF216 TNKS BCL10 PPP6R2	3.79e-05	1038	165	16	26673895
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	NELFE UBE4B RNF213 SRCAP ECPAS PPP1R10 KMT2D UBXN7 AFF4	3.95e-05	341	165	9	32971831
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	CAND1 VPS13C TOM1 RNF213 PSMD3 KMT2D SF3B1 KPNA2	4.07e-05	264	165	8	32814769
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	DLGAP1 ANK2 EPB41L4B SPTB CALCOCO1 SHANK3 MAPK8IP3	4.59e-05	197	165	7	36604605
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CASP8AP2 RALGDS AGAP5 CAND1 VPS13C SCRN1 ADGRV1 ECPAS DICER1 UBXN7 FTO	4.88e-05	529	165	11	14621295
Pubmed	Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.	CAND1 VPS13C PSMD3 SF3B1	5.22e-05	43	165	4	26030138
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	CFAP47 SGSM1 EPB41L4B VPS13C CAMSAP3 RNF213 LRRC40 ECPAS FREM2 RPAP1 VPS13A ALB DOP1B	5.38e-05	736	165	13	29676528
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	EGLN2 CAND1 COPB1 CALCOCO1 MIER3 CAST ADGRV1 SEPTIN3 AP2A1 MITF RNF216 KLHL18 IQCG	6.50e-05	750	165	13	11230166
Pubmed	VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites.	VPS13C VPS13A	6.69e-05	3	165	2	30093493
Pubmed	A classical NLS and the SUN domain contribute to the targeting of SUN2 to the inner nuclear membrane.	COPB1 KPNA2	6.69e-05	3	165	2	20551905
Pubmed	Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells.	ATRX TNKS	6.69e-05	3	165	2	26373281
Pubmed	ESR1, FTO, and UCP2 genes interact with bariatric surgery affecting weight loss and glycemic control in severely obese patients.	ESR1 FTO	6.69e-05	3	165	2	21720911
Pubmed	Transcriptional induction of NF-κB-inducing kinase by E2F4/5 facilitates collective invasion of GBM cells.	E2F4 E2F5	6.69e-05	3	165	2	37567906
Pubmed	Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines.	AXIN2 TNKS	6.69e-05	3	165	2	33811251
Pubmed	Distinct capacities of individual E2Fs to induce cell cycle re-entry in postmitotic lens fiber cells of transgenic mice.	E2F4 E2F5	6.69e-05	3	165	2	15855772
Pubmed	A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport.	ANK2 PIK3C3	6.69e-05	3	165	2	25533844
Pubmed	The pro-death role of Cited2 in stroke is regulated by E2F1/4 transcription factors.	E2F4 CITED2	6.69e-05	3	165	2	30967472
Pubmed	Regulated vesicular trafficking of specific PCDH15 and VLGR1 variants in auditory hair cells.	ADGRV1 PCDH15	6.69e-05	3	165	2	23035094
Pubmed	PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation.	EGLN2 ATF4	6.69e-05	3	165	2	21951999
Pubmed	Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.	AXIN2 ALB	6.69e-05	3	165	2	30500538
Pubmed	Interplay between the retinoblastoma related pRb2/p130 and E2F-4 and -5 in relation to JCV-TAg.	E2F4 E2F5	6.69e-05	3	165	2	17385710
Pubmed	Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor.	NELFE ESR1	6.69e-05	3	165	2	15342491
Pubmed	TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO.	TRIM41 BCL10	6.69e-05	3	165	2	33640899
Pubmed	TBC1D1 interacting proteins, VPS13A and VPS13C, regulate GLUT4 homeostasis in C2C12 myotubes.	VPS13C VPS13A	6.69e-05	3	165	2	33087848
Pubmed	E2f4 and E2f5 are essential for the development of the male reproductive system.	E2F4 E2F5	6.69e-05	3	165	2	26825228
Pubmed	Contribution of ENPP1, TCF7L2, and FTO polymorphisms to type 2 diabetes in mixed ancestry ethnic population of South Africa.	ENPP1 FTO	6.69e-05	3	165	2	26958016
Pubmed	Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.	DOP1A DOP1B	6.69e-05	3	165	2	16301316
Pubmed	CUEDC1 is a primary target of ERα essential for the growth of breast cancer cells.	ESR1 TOM1	6.69e-05	3	165	2	30145202
Pubmed	Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements.	DUX5 DUX3 DUX1	6.79e-05	17	165	3	11245978
Pubmed	Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin.	F5 ATF4 ALB	6.79e-05	17	165	3	21795745
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	MAP4 HDX CAMSAP3 PSMD3 FRYL TASOR2 SF3B1 KHDRBS3 ALB SPINDOC KPNA2	7.01e-05	551	165	11	34728620
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	GPX1 NCAPH2 DICER1 STRIP2 PIK3C3 ALB PPP6R2	7.29e-05	212	165	7	33853758
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	DLGAP1 ATRX CALCOCO1 FRYL STK32C SHANK3 AXIN2 TASOR2 MAPK8IP3 KANSL2 KHDRBS3	8.09e-05	560	165	11	21653829
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	NELFE ATRX UBE4B MAP4 CAMSAP3 CAST ECPAS C2CD5 MAPK8IP3 KMT2D KANSL2 SF3B1 RPAP1	8.91e-05	774	165	13	15302935
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	NELFE ANKRD13D AGAP5 SGSM1 SEC24A CAMSAP3 NUTM2D FRYL NCAPH2 CREB3L1 NUTM2G VPS13A FTO NUTM2F KLHL18 KAT14 DOP1B	9.29e-05	1242	165	17	30973865
Pubmed	Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.	CAND1 SPTB SCRN1 AP2A1 VCAN	1.02e-04	97	165	5	22360420
Pubmed	Widespread macromolecular interaction perturbations in human genetic disorders.	TRIM41 WASHC3 PSMD3 NCAPH2 CREB3L1 TASOR2 KHDRBS3 BCL10 ATF4 HSF2 GPRASP2	1.28e-04	590	165	11	25910212
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	UBE4B ADGRV1 ZNF623 PPP6R2 ULK2	1.30e-04	102	165	5	9734811
Pubmed	B-cell lymphoma/leukemia 10 promotes oral cancer progression through STAT1/ATF4/S100P signaling pathway.	BCL10 ATF4	1.33e-04	4	165	2	24681956
Pubmed	Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism.	ADGRV1 PCDH15	1.33e-04	4	165	2	18463160
Pubmed	Inducing mutations in the mouse genome with the chemical mutagen ethylnitrosourea.	KMT2D PCDH15	1.33e-04	4	165	2	16972005
Pubmed	Intracellular trafficking and dynamics of double homeodomain proteins.	DUX5 DUX1	1.33e-04	4	165	2	15709750
Pubmed	Risk of cerebral venous thrombosis and novel gene polymorphisms of the coagulation and fibrinolytic systems.	F5 TAF1	1.33e-04	4	165	2	16155788
Pubmed	Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear flow.	PODXL MUC16	1.33e-04	4	165	2	26329844
Pubmed	Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs.	NELFE TNKS	1.33e-04	4	165	2	29604130
Pubmed	Maternal IVS1-401 T allele of the estrogen receptor alpha is an independent predictor of late fetal loss.	ESR1 F5	1.33e-04	4	165	2	16753154
Pubmed	Role for a novel Usher protein complex in hair cell synaptic maturation.	ADGRV1 PCDH15	1.33e-04	4	165	2	22363448
Pubmed	MicroRNAs link estrogen receptor alpha status and Dicer levels in breast cancer.	ESR1 DICER1	1.33e-04	4	165	2	21761362
Pubmed	Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells.	ADGRV1 PCDH15	1.33e-04	4	165	2	33009420
Pubmed	Analysis of the human VPS13 gene family.	VPS13C VPS13A	1.33e-04	4	165	2	15498460
Pubmed	Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3 kb dispersed repeated elements.	DUX5 DUX1	1.33e-04	4	165	2	9736770
Pubmed	The role of the C-terminal domain of PCSK9 and SEC24 isoforms in PCSK9 secretion.	SEC24A SEC24B	1.33e-04	4	165	2	32058034
Pubmed	Wnt/beta-catenin and estrogen signaling converge in vivo.	ESR1 AXIN2	1.33e-04	4	165	2	15304487
Pubmed	The subcellular localization of E2F-4 is cell-cycle dependent.	E2F4 E2F5	1.33e-04	4	165	2	9144196
Pubmed	A Genome-Wide Screen for Machinery Involved in Downregulation of MHC Class I by HIV-1 Nef.	KCTD19 CAMSAP3	1.33e-04	4	165	2	26466362
Pubmed	Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor.	ESR1 TAF1	1.33e-04	4	165	2	7923369
Pubmed	Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells.	PODXL PODXL2	1.33e-04	4	165	2	15701716
Pubmed	Plasma membrane-cytoskeleton-endoplasmic reticulum complexes in neurons and astrocytes.	ANK2 SPTB	1.33e-04	4	165	2	14593108
Interaction	TSPY8 interactions	TSPY3 TSPY2 TSPY8	5.10e-07	3	162	3	int:TSPY8
Interaction	EP300 interactions	NELFE CAND1 COPB1 MAP4 SEC24A ESR1 CALCOCO1 ETS1 PSMD3 E2F4 E2F5 NR6A1 DBP SRCAP ECPAS C2CD5 MAPK8IP3 CITED2 ZNF469 KMT2D SF3B1 AP2A1 SEC24B MITF ATF4 NUTM2F HSF2 SNX9 KPNA2	2.23e-06	1401	162	29	int:EP300
Interaction	DNMT3L interactions	ESR1 ETS1 E2F4 E2F5 NR6A1 ATF4 DNMT3L	7.00e-06	88	162	7	int:DNMT3L
Interaction	FAM78B interactions	ANKRD13D VPS13C FRYL	1.00e-05	6	162	3	int:FAM78B
Cytoband	Ensembl 112 genes in cytogenetic band chr22q13	ENTHD1 NCAPH2 ST13 SHANK3 SEPTIN3 ATF4 PPP6R2	1.83e-04	330	162	7	chr22q13
Cytoband	Yp11.2	TSPY3 TSPY2 TSPY8 TSPY10	3.56e-04	94	162	4	Yp11.2
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	CAND1 ATRX PODXL SEC24A TRPC1 E2F5 FRYL DICER1 C2CD5 SACS PIK3C3 UBXN7 SEC24B MITF VPS13A SERPINB2 TNKS FTO DOP1B	1.06e-06	856	158	19	M4500
Coexpression	GSE37301_HEMATOPOIETIC_STEM_CELL_VS_RAG2_KO_NK_CELL_DN	RALGDS ENPP1 SEC24A ETS1 FAAH CITED2 PTPRS ATF4 ULK2	1.78e-06	183	158	9	M8886
ToppCell	(08)_PNEC-(2)_48hpi\|(08)_PNEC / shred by cell type and Timepoint	ENPP1 SEC24A HDX CAST PODXL2 GTF2E1 FRMD3	8.74e-07	142	161	7	e95d34170f5053678e0dd9793e68d93c03b05822
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-4\|TCGA-Lung / Sample_Type by Project: Shred V9	SEC24A ESR1 SPTB HDX RNF213 VCAN CDH11	3.65e-06	176	161	7	0923b01137d6f9956ca815b41102c81e82624065
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ENPP1 HDX CMYA5 RPAP1 PTPRS MITF SPOCD1	7.91e-06	198	161	7	cc2b5b632e73e44bb60050f0db10d8f0dbb859fa
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ATRX VPS13C CAST RNF213 FRYL SF3B1 AFF4	8.45e-06	200	161	7	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	facs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DLGAP1 ESR1 ZBTB8B ENTHD1 MAPK8IP3 SEPTIN3	1.66e-05	148	161	6	5983c4546f527a0b599cfcbd8a6cb937a1d6f895
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CFAP47 IQCH EPB41L4B CMYA5 PLIN5 PCDH15	1.72e-05	149	161	6	c5eedb54ef2e0f131aa6730612c921bc19479632
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CFAP47 IQCH EPB41L4B CMYA5 PLIN5 PCDH15	1.72e-05	149	161	6	a22417286de8606f0cc94f86b70bce17aeefb9c2
ToppCell	Severe-B_naive-5\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	AXIN2 ZNF469 PLIN5 BCL10 CDH11 FRMD3	2.31e-05	157	161	6	a57ee4a6febdff3ee3d1645836695e6e7c055cf8
ToppCell	Bronchial_Biopsy-Immune-Neutrophils\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	SGSM1 EPB41L4B ZFP37 ZNF469 SERPINB2 TIGD5	2.76e-05	162	161	6	985adca17b0c99563feef7910f3da5df31e636b6
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPB41L4B VSIG1 NR6A1 KHDRBS3 SNX9 IQCG	2.96e-05	164	161	6	d9531848105d606adedde65426177cf851140e31
ToppCell	368C-Myeloid-Dendritic-pDC\|368C / Donor, Lineage, Cell class and subclass (all cells)	FAAH ZNF469 RPAP1 SUSD1 PTPRS DOP1B	3.27e-05	167	161	6	1e2fc1637769405a61f4c7e44945712a1888a299
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZBTB8B MUC16 SMCO2 CREB3L1 FREM2 AHNAK2	3.27e-05	167	161	6	7abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZBTB8B MUC16 SMCO2 CREB3L1 FREM2 AHNAK2	3.27e-05	167	161	6	d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_SLITRK6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PLCZ1 CREB3L1 VCAN MITF PCDH15 FRMD3	3.50e-05	169	161	6	1c9e54e7b14eb99996590fb93b257cf881a9f184
ToppCell	COVID_vent-Lymphocytic-Dendritic-pDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	BCL2L10 SCRN1 PTPRS SNX9 AHNAK2 PHACTR1	3.74e-05	171	161	6	779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCell	COVID_vent-Lymphocytic-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	BCL2L10 SCRN1 PTPRS SNX9 AHNAK2 PHACTR1	3.74e-05	171	161	6	debbb071d260639b16269c94d172766908325c58
ToppCell	368C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	FAAH ZNF469 RPAP1 SUSD1 PTPRS DOP1B	3.74e-05	171	161	6	714a0b0d0c9886fef64170cf53eb64f0d8a47280
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RNF213 CITED2 MITF TNFAIP2 SPOCD1 KLHL18	3.86e-05	172	161	6	c8ea80042faf923b08ff03d73100533d521d73ef
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE1B RNF213 SEPTIN3 VCAN TNFAIP2 SPOCD1	4.12e-05	174	161	6	d5c22b43531414951666ee7542a66ed9380e2d14
Drug	Isopropamide iodide [71-81-8]; Up 200; 8.4uM; MCF7; HT_HG-U133A	ATP6V0A1 ATRX MAP4 CALCOCO1 E2F4 NCAPH2 NR6A1 SRCAP ECPAS IQCG	1.11e-06	196	157	10	3461_UP
Drug	Fluvoxamine maleate [61718-82-9]; Up 200; 9.2uM; MCF7; HT_HG-U133A	MAP4 VPS13C ESR1 CALCOCO1 E2F4 SRCAP LPIN1 VPS13A TNFAIP2 HSF2	1.11e-06	196	157	10	7333_UP
Drug	LY 294002; Up 200; 0.1uM; MCF7; HT_HG-U133A	ATP6V0A1 ATRX LONP2 SEC24A TRPC1 SPTB NCAPH2 SRCAP AHNAK2 IQCG	1.16e-06	197	157	10	1641_UP
Drug	17-DMAG; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA	RALGDS ATRX SRCAP ABCA7 DICER1 MAPK8IP3 LPIN1 VPS13A RNF216	7.41e-06	191	157	9	993_UP
Drug	Forskolin, from Coleus forskohlii; Down 200; 0.5uM; PC3; HT_HG-U133A	EGLN2 VPS13C TRPC1 NCAPH2 SRCAP VCAN RNF216 ULK2 DOP1A	7.73e-06	192	157	9	7104_DN
Drug	Sulfabenzamide [127-71-9]; Down 200; 14.4uM; MCF7; HT_HG-U133A	RALGDS ATP6V0A1 MAP4 ESR1 E2F5 PTPRS TNFAIP2 PPP6R2 MVB12B	9.90e-06	198	157	9	4979_DN
Drug	Pyrazinamide [ 98-96-4]; Down 200; 32.4uM; MCF7; HT_HG-U133A	TRPC1 CALCOCO1 PODXL2 E2F4 ZNF623 CITED2 RNF216 MVB12B IQCG	9.90e-06	198	157	9	2839_DN
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A	BCL2L10 SPTB CALCOCO1 NR6A1 VCAN TNKS TNFAIP2 MVB12B	4.99e-05	188	157	8	5596_UP
Drug	Maprotiline hydrochloride [10347-81-6]; Up 200; 12.8uM; MCF7; HT_HG-U133A	SPTB LPIN1 RPAP1 VCAN TNFAIP2 CDH11 AHNAK2 IQCG	5.79e-05	192	157	8	3236_UP
Drug	alpha-estradiol; Down 200; 0.01uM; MCF7; HT_HG-U133A_EA	MAP4 TRPC1 APBA3 PODXL2 E2F4 SRCAP FAAH TAF1	6.22e-05	194	157	8	990_DN
Drug	trifluoperazine dihydrochloride; Up 200; 10uM; HL60; HT_HG-U133A	BCL2L10 ENPP1 F5 CREB3L1 FAAH TNKS ULK2 DNMT3L	6.45e-05	195	157	8	6183_UP
Drug	Bupivacaine hydrochloride [18010-40-7]; Up 200; 12.4uM; MCF7; HT_HG-U133A	LONP2 TRPC1 DBP SRCAP LPIN1 HSF2 DOP1B MVB12B	6.45e-05	195	157	8	7435_UP
Drug	Diphenidol hydrochloride [3254-89-5]; Up 200; 11.6uM; MCF7; HT_HG-U133A	BCL2L10 ESR1 NCAPH2 ABCA7 FAAH VCAN TAF1 MVB12B	6.45e-05	195	157	8	7406_UP
Drug	Atracurium besylate [64228-81-5]; Down 200; 3.2uM; MCF7; HT_HG-U133A	RALGDS TRPC1 APBA3 NCAPH2 RPAP1 MITF RNF216 PPP6R2	6.69e-05	196	157	8	7477_DN
Drug	(-)-Eseroline fumarate salt [104015-29-4]; Down 200; 12uM; MCF7; HT_HG-U133A	LONP2 ESR1 APBA3 E2F4 TAF1 PPP6R2 ULK2 DOP1A	6.69e-05	196	157	8	7027_DN
Drug	Aceclofenac [89796-99-6]; Down 200; 11.2uM; MCF7; HT_HG-U133A	UBE4B MAP4 ESR1 TRPC1 APBA3 E2F4 NCAPH2 TNFAIP2	6.69e-05	196	157	8	7029_DN
Drug	Sulfasalazine [599-79-1]; Down 200; 10uM; MCF7; HT_HG-U133A	TRPC1 E2F4 NCAPH2 ZFP37 RPAP1 VPS13A AFF4 IQCG	6.69e-05	196	157	8	5446_DN
Drug	Sulpiride [15676-16-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A	APBA3 E2F4 NR6A1 SRCAP MAPK8IP3 PTPRS PPP6R2 AHNAK2	6.93e-05	197	157	8	1467_UP
Drug	S(-)Eticlopride hydrochloride [97612-24-3]; Down 200; 10.6uM; HL60; HT_HG-U133A	MAP4 ESR1 PODXL2 E2F4 F5 ZFP37 RPAP1 PTPRS	6.93e-05	197	157	8	3056_DN
Drug	Talampicillin hydrochloride [39878-70-1]; Down 200; 7.8uM; MCF7; HT_HG-U133A	RALGDS LONP2 E2F4 NCAPH2 LPIN1 RPAP1 ULK2 AFF4	6.93e-05	197	157	8	3515_DN
Drug	Dizocilpine maleate [77086-22-7]; Up 200; 11.8uM; PC3; HT_HG-U133A	RALGDS ESR1 TRPC1 E2F4 NR6A1 CREB3L1 PTPRS DOP1A	7.18e-05	198	157	8	5746_UP
Drug	Phenformin hydrochloride [834-28-6]; Up 200; 16.6uM; MCF7; HT_HG-U133A	ATP6V0A1 SPTB NR6A1 MAPK8IP3 VCAN TNFAIP2 CDH11 AHNAK2	7.18e-05	198	157	8	2312_UP
Drug	2-propylpentanoic acid; Down 200; 1000uM; MCF7; HT_HG-U133A	UBE4B MAP4 TRPC1 PODXL2 E2F4 GMIP SRCAP HSF2	7.18e-05	198	157	8	6929_DN
Drug	Cromolyn disodium salt [15826-37-6]; Down 200; 7.8uM; MCF7; HT_HG-U133A	MAP4 ACTR5 ESR1 TRPC1 CALCOCO1 CITED2 LPIN1 TNFAIP2	7.18e-05	198	157	8	3475_DN
Drug	Propidium iodide [25535-16-4]; Down 200; 6uM; MCF7; HT_HG-U133A	MAP4 PODXL2 E2F4 NCAPH2 SRCAP F5 MAPK8IP3 ULK2	7.18e-05	198	157	8	6104_DN
Drug	Fursultiamine Hydrochloride [2105-43-3]; Up 200; 9.2uM; MCF7; HT_HG-U133A	ATP6V0A1 ESR1 TRPC1 NR6A1 SRCAP FAAH PTPRS TNFAIP2	7.18e-05	198	157	8	7349_UP
Drug	Cefaclor [70356-03-5]; Up 200; 10.4uM; HL60; HT_HG-U133A	MAP4 NR6A1 MAPK8IP3 TBC1D16 KHDRBS3 PTPRS CDH11 DOP1B	7.44e-05	199	157	8	2483_UP
Drug	N6,2-O-dibutyryladenosine 3,5-cyclic monophosphate sodium salt; Down 200; 2uM; MCF7; HT_HG-U133A_EA	MAP4 ESR1 APBA3 SRCAP FAAH VPS13A HSF2 DOP1A	7.44e-05	199	157	8	959_DN
Drug	Tetrahydroxy-1,4-quinone monohydrate [319-89-1]; Up 200; 21uM; MCF7; HT_HG-U133A	PPP1R14D NCAPH2 F5 ABCA7 KHDRBS3 PTPRS TNFAIP2 KLHL18	7.44e-05	199	157	8	3338_UP
Drug	Disopyramide [3737-09-5]; Down 200; 11.8uM; HL60; HT_HG-U133A	RALGDS ANK2 MAP4 CAST SRCAP F5 MAPK8IP3 RPAP1	7.44e-05	199	157	8	2408_DN
Drug	prochlorperazine dimaleate salt; Down 200; 10uM; MCF7; HT_HG-U133A	MAP4 ESR1 CAST PODXL2 RPAP1 TAF1 PPP6R2 MVB12B	7.44e-05	199	157	8	5575_DN
Drug	Aminophylline [317-34-0]; Up 200; 9.6uM; PC3; HT_HG-U133A	BCL2L10 ESR1 SPTB TOM1 NCAPH2 ECPAS ABCA7 HSF2	7.44e-05	199	157	8	6295_UP
Drug	Yohimbinic acid monohydrate [27801-27-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	ATP6V0A1 MAP4 ESR1 SRCAP ZFP37 TNFAIP2 ULK2 AHNAK2	7.44e-05	199	157	8	2803_DN
Drug	Myosmine [532-12-7]; Up 200; 27.4uM; HL60; HT_HG-U133A	BCL2L10 MAP4 EPB41L4B PODXL2 NCAPH2 DICER1 DOP1B IQCG	7.44e-05	199	157	8	2199_UP
Drug	Isopyrin hydrochloride [18342-39-7]; Down 200; 14.2uM; PC3; HT_HG-U133A	RALGDS EGLN2 ATRX NCAPH2 GMIP VPS13A HSF2 PPP6R2	7.44e-05	199	157	8	5879_DN
Disease	Parkinson's disease 23 (implicated_via_orthology)	VPS13C VPS13A	2.71e-05	2	154	2	DOID:0060896 (implicated_via_orthology)
Disease	choreaacanthocytosis (implicated_via_orthology)	VPS13C VPS13A	2.71e-05	2	154	2	DOID:0050766 (implicated_via_orthology)
Disease	autosomal recessive spinocerebellar ataxia 4 (implicated_via_orthology)	VPS13C VPS13A	8.09e-05	3	154	2	DOID:0111611 (implicated_via_orthology)
Disease	Cohen syndrome (implicated_via_orthology)	VPS13C VPS13A	8.09e-05	3	154	2	DOID:0111590 (implicated_via_orthology)
Disease	Male Germ Cell Tumor	DICER1 BCL10	1.61e-04	4	154	2	C3496549
Disease	cardiovascular system disease (is_implicated_in)	ENPP1 GPX1 FTO	1.73e-04	21	154	3	DOID:1287 (is_implicated_in)
Disease	Antithrombotic agent use measurement	F5 TNKS FTO PHACTR1	1.98e-04	55	154	4	EFO_0009925
Disease	Hereditary Paraganglioma-Pheochromocytoma Syndrome	EGLN2 KMT2D MITF	2.29e-04	23	154	3	C1708353
Disease	pulmonary embolism (is_implicated_in)	F5 FTO	2.68e-04	5	154	2	DOID:9477 (is_implicated_in)
Disease	hair colour measurement	PODXL TRIM41 TOM1 NR6A1 ADGRV1 AXIN2 FREM2 ZNF469 KMT2D MITF FTO	4.04e-04	615	154	11	EFO_0007822
Disease	lung small cell carcinoma (is_implicated_in)	ATRX AXIN2 KMT2D	4.15e-04	28	154	3	DOID:5409 (is_implicated_in)
Disease	melanoma (is_marker_for)	ATRX ESR1 MITF	6.78e-04	33	154	3	DOID:1909 (is_marker_for)
Disease	cerebellar ataxia (implicated_via_orthology)	VPS13C VPS13A	7.42e-04	8	154	2	DOID:0050753 (implicated_via_orthology)
Disease	Obesity	ENPP1 ESR1 GPX1 FAAH FTO AFF4	7.48e-04	205	154	6	C0028754
Disease	multiple myeloma (is_marker_for)	BCL2L10 ALB FTO	8.77e-04	36	154	3	DOID:9538 (is_marker_for)
Disease	Colorectal Carcinoma	RALGDS ANK2 ZBTB8B STK32C F5 AXIN2 LPIN1 RPAP1 SACS PTPRS VPS13A	1.19e-03	702	154	11	C0009402
Disease	nevus count, cutaneous melanoma	ADGRV1 TASOR2 MITF FTO	1.34e-03	91	154	4	EFO_0000389, EFO_0004632
Disease	ceramide measurement	RALGDS PSMD3 ABCA7 SUSD1 PCDH15 FRMD3	1.51e-03	235	154	6	EFO_0010222
Disease	alcohol use disorder measurement, alcohol consumption measurement	CREB3L1 PCDH15 FTO AFF4	1.70e-03	97	154	4	EFO_0007878, EFO_0009458
Disease	Oligospermia	ESR1 DICER1	1.73e-03	12	154	2	C0028960
Disease	intracranial aneurysm (is_implicated_in)	KMT2D VCAN	1.73e-03	12	154	2	DOID:10941 (is_implicated_in)
Disease	colon carcinoma (is_marker_for)	AXIN2 KMT2D	2.03e-03	13	154	2	DOID:1520 (is_marker_for)
Disease	prostate carcinoma (is_implicated_in)	E2F5 ATF4	2.03e-03	13	154	2	DOID:10286 (is_implicated_in)
Disease	asthma, body mass index	PSMD3 PIK3C3	2.36e-03	14	154	2	EFO_0004340, MONDO_0004979
Disease	5-methyluridine (ribothymidine) measurement	NCAPH2 PTPRS	2.36e-03	14	154	2	EFO_0020013
Disease	body weight	COPB1 EPB41L4B VPS13C ESR1 HDX CAST WASHC3 ADGRV1 AXIN2 SUSD1 UBXN7 PCDH15 FTO NUTM2F PHACTR1	2.55e-03	1261	154	15	EFO_0004338
Disease	Down syndrome (implicated_via_orthology)	DOP1A DOP1B	2.72e-03	15	154	2	DOID:14250 (implicated_via_orthology)
Disease	response to platinum based chemotherapy, magnesium measurement	TBC1D16 PCDH15	2.72e-03	15	154	2	EFO_0004647, EFO_0004845
Disease	anemia (implicated_via_orthology)	GPX1 SLC4A5	2.72e-03	15	154	2	DOID:2355 (implicated_via_orthology)
Disease	peripheral arterial disease	F5 CREB3L1 KPNA2	2.85e-03	54	154	3	EFO_0004265
Disease	Acute Cerebrovascular Accidents	ANK2 F5 ALB	2.85e-03	54	154	3	C0751956
Disease	response to acetylsalicylate	MAP4 KLHL18	3.10e-03	16	154	2	GO_1903492
Disease	von Willebrand factor measurement	NELFE EPB41L4B STKLD1	3.16e-03	56	154	3	EFO_0004629
Disease	non-Hodgkin lymphoma (is_implicated_in)	GPX1 BCL10	3.50e-03	17	154	2	DOID:0060060 (is_implicated_in)
Disease	peripheral arterial disease, traffic air pollution measurement	EPB41L4B ESR1 CAMSAP3 ISOC1 NUTM2F	3.58e-03	194	154	5	EFO_0004265, EFO_0007908
Disease	cutaneous melanoma	ADGRV1 TASOR2 MITF FTO	3.78e-03	121	154	4	EFO_0000389
Disease	Brain Ischemia	GPX1 F5 ALB	3.84e-03	60	154	3	C0007786
Disease	Cerebral Ischemia	GPX1 F5 ALB	3.84e-03	60	154	3	C0917798
Disease	migraine disorder, systolic blood pressure	RNF213 PHACTR1	3.92e-03	18	154	2	EFO_0006335, MONDO_0005277
Disease	response to opioid	DLGAP1 MUC16 MVB12B	4.02e-03	61	154	3	EFO_0008541
Disease	age at menarche	DLGAP1 IQCH TRIM41 CAST NR6A1 ECPAS TBC1D16 FTO SPINDOC	4.11e-03	594	154	9	EFO_0004703
Disease	Depressive disorder	PDE1B ESR1 GPX1 ATF4 ALB FTO	4.21e-03	289	154	6	C0011581
Disease	Cerebrovascular accident	ANK2 F5 ALB	4.21e-03	62	154	3	C0038454
Disease	IGF-1 measurement	VPS13C ESR1 TRIM41 WASHC3 SRCAP MAPK8IP3 ULK2 DOP1B	4.23e-03	488	154	8	EFO_0004627
Disease	Malignant Neoplasms	ESR1 DICER1 CITED2 SF3B1	4.61e-03	128	154	4	C0006826
Disease	Deaf Mutism	MITF PCDH15	4.83e-03	20	154	2	C4082305
Disease	Deafness, Acquired	MITF PCDH15	4.83e-03	20	154	2	C0751068
Disease	Hearing Loss, Extreme	MITF PCDH15	4.83e-03	20	154	2	C0086395
Disease	Complete Hearing Loss	MITF PCDH15	4.83e-03	20	154	2	C0581883
Disease	Bilateral Deafness	MITF PCDH15	4.83e-03	20	154	2	C3665473
Disease	coagulation factor V measurement	F5 SUSD1	4.83e-03	20	154	2	EFO_0008087
Disease	Lymphoma, Follicular	KMT2D BCL10	4.83e-03	20	154	2	C0024301
Disease	Prelingual Deafness	MITF PCDH15	4.83e-03	20	154	2	C0011052
Disease	breast carcinoma (is_marker_for)	BCL2L10 ESR1 KMT2D	5.02e-03	66	154	3	DOID:3459 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DPVLDEKSPLLDMEL	CREB3L1	61	Q96BA8
EMPADLPSLAADFVE	ALB	321	P02768
QEPETLLAAMRPSEE	ANKRD13D	206	Q6ZTN6
KPELLEEMEASPTEL	VCAN	2906	P13611
ALDPEAEPSMDVILV	DNMT3L	6	Q9UJW3
ELVALMADSVLSDSP	BCL2L10	76	Q9HD36
LDALLGIDDLETMPD	ATF4	96	P18848
AVPADLAEMAREPAE	CT47B1	206	P0C2W7
EALPAPSDDATALMT	GPX1	131	P07203
DEDLDLIPPKPMASS	FAM219B	166	Q5XKK7
NLTVSILPDDFPEMD	ADGRV1	2521	Q8WXG9
LDPDTLPAVATLLMD	CASTOR2	191	A6NHX0
MDLEGPRDILVPSED	APBA3	16	O96018
STDVLATVLEEMPPF	AP2A1	591	O95782
EMTPVEPATFAAELI	AXIN2	361	Q9Y2T1
LESQAVEALDLPMPG	DLGAP1	471	O14490
SETIPMVVSDFDLPD	DOP1A	1086	Q5JWR5
PSLEDVESMNDFDPL	ACTR5	401	Q9H9F9
ELLEMEPETAKFSPA	DICER1	1856	Q9UPY3
PSIEEADILPIMLSE	CASP8AP2	766	Q9UKL3
APPEALSSEMSELSA	CAMSAP3	591	Q9P1Y5
LMELVGQEPESALPD	ABCA7	246	Q8IZY2
MEEKELLSPLSEPDD	AFF4	696	Q9UHB7
MEEDSLEDSNLPPKV	IQCG	1	Q9H095
ILSDPEALAAMQDPE	ST13P5	316	Q8NFI4
ILSDPEVLAAMQDPE	ST13	316	P50502
AVADMLDIPILGSEP	IQCH	586	Q86VS3
APLGLMDTPLLDTEE	KCTD19	156	Q17RG1
PVLASPDLLSEVSEM	ANK2	1496	Q01484
LEPLDSEEPSETMGL	PODXL2	56	Q9NZ53
TEDLMTFLDDDPELP	ENTHD1	236	Q8IYW4
DMLDASLEPETTSAP	MUC16	9476	Q8WXI7
ILDTPQAADLDEFPM	PADI6	376	Q6TGC4
PEEAEDRFSMPLIIT	PODXL	451	O00592
LEVPVSDLLEDMFSL	LPCAT1	376	Q8NF37
SMVLPEVEAALAEIP	ISOC1	186	Q96CN7
LLSDLPPELEEMDFN	HDX	651	Q7Z353
ESISDTTDLALPPEM	LONP2	611	Q86WA8
MADLSLADALTEPSP	MAP4	1	P27816
ETEVALARDMTLPPE	MAP4	441	P27816
DSTPELDMCPETRLD	MAPK8IP3	346	Q9UPT6
MLVIPPGLSEEEEAL	NELFE	1	P18615
ITADLSLPMAPESAA	MGAM2	966	Q2M2H8
TLEMLAGDPLLSEDP	GMIP	36	Q9P107
ASMPLPFDLTDIVSE	FTO	481	Q9C0B1
QPLAEDMEALSLPEL	DOP1B	511	Q9Y3R5
PEMALLTALDDTLPE	DUX5	26	Q96PT3
TDDLMLTFLLEDPPL	FREM2	976	Q5SZK8
TAAMIDAVLDELPPL	CAND1	686	Q86VP6
IESLATMEPDSRPEL	ECPAS	1816	Q5VYK3
TEKVDLELFPSPDME	ETS1	16	P14921
TADQMVSALLDAEPP	ESR1	311	P03372
MLEESDCPSPLELKS	PDE1B	11	Q01064
MDSEPPSEISLKNDL	COPB1	16	P53618
TPSLLSEADLIPDVM	KAT14	346	Q9H8E8
GILDLEETEMPEPLA	FRYL	2596	O94915
EDLETLGAAAPLLPM	LPIN1	346	Q14693
AASLLAPMDVGEEPL	ENPP1	46	P22413
PSELADELPDMTLDK	MIER3	91	Q7Z3K6
TMPEVKDLSEALPET	MVB12B	31	Q9H7P6
KDLSEALPETSMDPI	MVB12B	36	Q9H7P6
TPLGSPEDMDLEELI	PTPRS	1171	Q13332
LLPPTLMAASSEDDI	PHACTR1	41	Q9C0D0
VDPLLALLAVPDMSS	KPNA2	206	P52292
DDPTSNDTFEIPLML	PCDH15	196	Q96QU1
FESSPELVEKEPMLA	BTBD18	446	B2RXH4
ASLLPTPVDDDEIDM	FRMD3	451	A2A2Y4
EDLDMDIVSVPSSVP	ATRX	511	P46100
TAMTAEPEPELDLES	GRID2IP	471	A4D2P6
SMSEEFLALPLEDVL	KLHL18	171	O94889
LPEDSSAVDMDILFP	C5orf60	6	A6NFR6
ELLEELMSSEVFAPL	E2F4	366	Q16254
DIIDELMSSDVFPLL	E2F5	301	Q15329
SEDKMSPASPIDDIE	EAF2	146	Q96CJ1
PASSLDDVFLPKDMD	FAM193B	841	Q96PV7
MEPTAPSLTEEDLTE	BCL10	1	O95999
LMSTSEVLEPEHELP	CMYA5	1516	Q8N3K9
SQDEELLMPPDALTD	TMEM63B	801	Q5T3F8
KISVEDADEPPMFLA	CDH11	371	P55287
PAMALLTALDDTLPE	DUX3	26	Q96PT4
EQLPPMSEDFLLDAL	CAST	501	P20810
PPDLVAEQFTLMDAE	RALGDS	386	Q12967
MALLTALDDTLPEEA	DUX1	1	O43812
VLSVPDDLEAGPMDL	KANSL2	376	Q9H9L4
LPELMAEKDSLDPSF	KHDRBS3	6	O75525
VLMTFEPDPADLALS	DBP	201	Q10586
LSMVILLPDDIEDES	SERPINB1	226	P30740
DLDVVLTPMLAPALD	FAAH	466	O00519
MEEALPSAPERLALD	EGLN2	166	Q96KS0
MLIVSDIDDVFLPTP	SEC24B	741	O95487
SEDLTLFDEMPLIPR	SACS	791	Q9NZJ4
LTDSEDESPEDMRLP	CALCOCO1	536	Q9P1Z2
PIMLIATEPDTDAVI	CFAP47	3026	Q6ZTR5
DLLMDFTEATPLAEP	EPB41L4B	756	Q9H329
DAMEDVHSLLTDVPP	C2CD5	686	Q86YS7
ELVSLITQDPPLDME	PPP6R2	56	O75170
LLETIPPELAGMESL	LRRC40	231	Q9H9A6
ELAPAPLDSDMPLLD	HSF2	521	Q03933
SEPEIDLEALMDLST	PPP1R14D	91	Q9NXH3
DVSMFLLLPDEIADV	SERPINB2	261	P05120
LEELLSPDPQMDFLA	NUTM2D	516	Q5VT03
LEELLSPDPQMDFLA	NUTM2F	466	A1L443
LEELLSPDPQMDFLA	NUTM2G	451	Q5VZR2
QLLSAEDLEPLGTPM	NR6A1	256	Q15406
MADPDVLTEVPAALK	GTF2E1	1	P29083
STMEPEAPDLDLVEI	SNX9	381	Q9Y5X1
VDLTLDPDTAHPALM	TRIM41	431	Q8WV44
DSINILADVLPEEMP	STRIP2	536	Q9ULQ0
PDLSEMPLFADLSQI	F5	1386	P12259
MLDDFPDTLPSPEAL	PLCZ1	276	Q86YW0
SDIEDVFIPMPENLL	SEC24A	571	O95486
MTDLPELDTPESARI	SEC24A	1021	O95486
LEEAELESLDPMTPG	TAF1	1626	P21675
MSLIDDDFSLEPLIS	GPRASP2	796	Q96D09
SLMVDANIPDIALEP	PIK3C3	821	Q8NEB9
MPAEIVVLLDSEDNP	SPINDOC	171	Q9BUA3
DSSDEERIPMLVTPA	RNF216	36	Q9NWF9
IRELFDMPLEEPSSS	SRCAP	2206	Q6ZRS2
EAMEEILTSSEPLDP	SCRN1	381	Q12765
PTFELEEMILESRPL	STK32C	381	Q86UX6
VDLSAPKVEADMSLP	AHNAK2	1351	Q8IVF2
EMPEALEFSLSANPE	AGAP5	71	A6NIR3
AMLPPNVIDTDFIDE	CITED2	211	Q99967
DPREAADLDAVPMSL	NCAPH2	451	Q6IBW4
ASPALIMLTEEDPIL	TRPC1	221	P48995
SAPDRLESMEVDLSP	RNF212	151	Q495C1
SEILPEMASQFPEEI	RNF213	5171	Q63HN8
SQLMDADLEVSLVPP	TMEM210	106	A6NLX4
GPMTPESALEELLAV	TSPY10	101	P0CW01
GPMTPESALEELLAV	TSPY2	101	A6NKD2
MSEASSEDLVPPLEA	TNFAIP2	1	Q03169
PETLEEMLTPEEKAL	VPS13A	451	Q96RL7
SEPMAVPDLDIELEL	VSIG1	336	Q86XK7
LLPFLEEPMDTEADL	PSMD3	131	O43242
MDDTLSPVGVTDPLL	MITF	486	O75030
EMLAAAAEPTLRPDI	SHANK3	716	Q9BYB0
LAIDPLLDAAPVDMA	PYROXD2	171	Q8N2H3
SALQSHPEEEPLLVM	STKLD1	421	Q8NE28
PETRTDAAMSELVPE	SEPTIN3	6	Q9UH03
NRPLSDEELDAMFPE	SF3B1	396	O75533
EMLTELVPTQAEPAD	TOM1	236	O60784
KAPSEAEPAADLIDM	TOM1	311	O60784
LEVLEDLMEVSSPSP	SPOCD1	501	Q6ZMY3
ELLAKDVPDDAMEIP	SUSD1	656	Q6UWL2
DDIRALLIDAMPPEA	TNKS	946	O95271
SDAPDEFRDPLMDTL	UBE4B	1226	O95155
RMLASPAPEDEEKLA	TBC1D16	151	Q8TBP0
DEAPNPTLFTEMDTL	SLC4A5	106	Q9BY07
LIPETIDDLMTPEEK	VPS13C	491	Q709C8
SEDMPESLPEAEQLL	SPTB	1086	P11277
DTEEMEALLPQAPAS	SMCO2	251	A6NFE2
EEPEMESLFPALASL	SGSM1	891	Q2NKQ1
ALPPEEAEMLSTEAL	RPAP1	661	Q9BWH6
GPMTPESALEELLAV	TSPY3	101	P0CV98
GPMTPESALEELLAV	TSPY8	101	P0CW00
PLPASDLDMEDDAKL	ZNF469	826	Q96JG9
EMADPDLLEESSSLL	ATP6V0A1	141	Q93050
ITFEAPELPEETLME	ULK2	806	Q8IYT8
PPSHVVDLLDSIEDM	YAE1	126	Q9NRH1
AVDSEILEMPPEKAD	UBXN7	386	O94888
LVMTPDPEFLVSEAE	TASOR2	301	Q5VWN6
LPMTEEELAALAAEA	PLIN5	166	Q00G26
AASMPALDSEDAPVR	TIGD5	366	Q53EQ6
DRLTVMELPSPESEE	ZNF623	36	O75123
MISEGLDPDLLERPD	WASHC3	156	Q9Y3C0
VPELMDTASLEPGAL	PPP1R10	361	Q96QC0
PLEMAVSEPEASAAE	ZFP37	31	Q9Y6Q3
DMLEPEAELAEDLPT	XRRA1	481	Q6P2D8
PDDDDDLMPINLSLV	ZBTB8B	431	Q8NAP8
PEDSLMSLPLEESPL	KMT2D	711	O14686