Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H2AXS139 kinase activity	ATR ATM	9.83e-05	3	115	2	GO:0035979
GeneOntologyMolecularFunction	peptidase activity	CYLD PSMB10 ADAMTS13 USP9Y MMP25 USP38 TPP1 TMPRSS11D IMMP1L PCSK7 MMP19 CPVL ZRANB1	1.01e-04	654	115	13	GO:0008233
GeneOntologyMolecularFunction	histone H2AX kinase activity	ATR ATM	3.25e-04	5	115	2	GO:0141003
GeneOntologyBiologicalProcess	telomerase catalytic core complex assembly	ATR ATM	3.03e-05	2	114	2	GO:1904868
GeneOntologyBiologicalProcess	positive regulation of telomerase catalytic core complex assembly	ATR ATM	3.03e-05	2	114	2	GO:1904884
GeneOntologyBiologicalProcess	regulation of telomerase catalytic core complex assembly	ATR ATM	3.03e-05	2	114	2	GO:1904882
GeneOntologyBiologicalProcess	amide biosynthetic process	ACSL6 ENPP7 ACLY SPTLC1 B4GALT5 SLC25A1 SMPD2	4.83e-05	172	114	7	GO:0043604
GeneOntologyBiologicalProcess	positive regulation of telomere maintenance via telomere lengthening	ATR RTEL1 MAPK15 ATM	6.27e-05	39	114	4	GO:1904358
GeneOntologyBiologicalProcess	replicative senescence	ATR CHEK1 ATM	8.74e-05	16	114	3	GO:0090399
GeneOntologyBiologicalProcess	establishment of RNA localization to telomere	ATR ATM	9.05e-05	3	114	2	GO:0097694
GeneOntologyBiologicalProcess	establishment of protein-containing complex localization to telomere	ATR ATM	9.05e-05	3	114	2	GO:0097695
Domain	SUI1_euk	EIF1B EIF1	3.63e-05	2	113	2	IPR005874
Domain	-	EIF1B EIF1	2.16e-04	4	113	2	3.30.780.10
Domain	SUI1	EIF1B EIF1	2.16e-04	4	113	2	PF01253
Domain	SUI1	EIF1B EIF1	2.16e-04	4	113	2	PS50296
Domain	U2AF_small	U2AF1L4 U2AF1	3.59e-04	5	113	2	IPR009145
Domain	SUI1	EIF1B EIF1	3.59e-04	5	113	2	IPR001950
Domain	FATC	ATR ATM	3.59e-04	5	113	2	PF02260
Domain	Peptidase_M10	ADAMTS13 MMP25 MMP19	3.98e-04	24	113	3	PF00413
Domain	FAT	ATR ATM	5.36e-04	6	113	2	PS51189
Domain	FATC	ATR ATM	5.36e-04	6	113	2	PS51190
Domain	FAT	ATR ATM	5.36e-04	6	113	2	PF02259
Domain	PIK-rel_kinase_FAT	ATR ATM	5.36e-04	6	113	2	IPR003151
Domain	FATC_dom	ATR ATM	5.36e-04	6	113	2	IPR003152
Domain	PIK_FAT	ATR ATM	5.36e-04	6	113	2	IPR014009
Domain	FATC	ATR ATM	5.36e-04	6	113	2	SM01343
Domain	ZnF_UBR1	UBR4 FBXO11	7.47e-04	7	113	2	SM00396
Domain	ZF_UBR	UBR4 FBXO11	7.47e-04	7	113	2	PS51157
Domain	zf-UBR	UBR4 FBXO11	7.47e-04	7	113	2	PF02207
Domain	Znf_UBR	UBR4 FBXO11	7.47e-04	7	113	2	IPR003126
Domain	Calx_beta	ITGB4 FREM2	9.92e-04	8	113	2	SM00237
Pathway	BIOCARTA_PLK3_PATHWAY	ATR CHEK1 ATM	1.24e-05	8	87	3	M22021
Pathway	KEGG_MEDICUS_REFERENCE_ATR_P21_CELL_CYCLE_G2_M	ATR CHEK1 ATM	1.86e-05	9	87	3	M47586
Pathway	KEGG_MEDICUS_REFERENCE_CDC25_CELL_CYCLE_G2_M	ATR CHEK1 ATM	2.64e-05	10	87	3	M47572
Pubmed	Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest.	ATR CHEK1 ATM	1.41e-07	4	115	3	26061604
Pubmed	ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1.	ATR CHEK1 ATM	1.41e-07	4	115	3	11390642
Pubmed	Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer.	ATR CHEK1 ATM	1.41e-07	4	115	3	18381943
Pubmed	Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression.	ATR CHEK1 ATM	1.41e-07	4	115	3	28808232
Pubmed	Large T antigen promotes JC virus replication in G2-arrested cells by inducing ATM- and ATR-mediated G2 checkpoint signaling.	ATR CHEK1 ATM	1.41e-07	4	115	3	19903823
Pubmed	The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.	ATR CHEK1 ATM	1.41e-07	4	115	3	21034966
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CYLD TTLL5 IQSEC2 UBR4 OBSL1 FBXO11 SRPK2 AIP USP9Y TRIP12 WDR19 U2AF1 CELSR3 KLHL7 TPP1 ATM ZNF565 LNX1	2.34e-07	1285	115	18	35914814
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SEMA3C ATR OBSL1 PEX6 SRPK2 PFKL ADCY6 DDX1 FREM2 TSR1 TPP1 HELZ PLCH1	2.57e-07	650	115	13	38777146
Pubmed	Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis.	ATR TPP1 ATM	3.50e-07	5	115	3	17948054
Pubmed	Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.	ATR CHEK1 ATM	3.50e-07	5	115	3	10859164
Pubmed	Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1).	ATR CHEK1 ATM	3.50e-07	5	115	3	21502314
Pubmed	Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase.	ATR CHEK1 ATM	3.50e-07	5	115	3	18480045
Pubmed	The many substrates and functions of ATM.	ATR CHEK1 ATM	3.50e-07	5	115	3	11252893
Pubmed	Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells.	ATR CHEK1 ATM	3.50e-07	5	115	3	16951182
Pubmed	The complexity of p53 modulation: emerging patterns from divergent signals.	ATR CHEK1 ATM	6.99e-07	6	115	3	9765199
Pubmed	Telomere protection by TPP1/POT1 requires tethering to TIN2.	ATR TPP1 ATM	1.22e-06	7	115	3	22099311
Pubmed	Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint.	ATR CHEK1 ATM	1.22e-06	7	115	3	17157788
Pubmed	The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.	ATR CHEK1 ATM	1.22e-06	7	115	3	10673501
Pubmed	p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress.	ATR CHEK1 ATM	1.95e-06	8	115	3	16705183
Pubmed	DNA damage repair machinery and HIV escape from innate immune sensing.	ATR CHEK1 ATM	1.95e-06	8	115	3	24795708
Pubmed	Vpr-induced DNA double-strand breaks: molecular mechanism and biological relevance.	ATR CHEK1 ATM	2.92e-06	9	115	3	19275579
Pubmed	Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.	OBSL1 FBXO11 DDX1 KLHL22 FBXO6 KLHL7	3.08e-06	120	115	6	27565346
Pubmed	Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.	ATR CHEK1 ATM	5.70e-06	11	115	3	11551930
Pubmed	UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts.	ATR CHEK1 ATM	5.70e-06	11	115	3	11709713
Pubmed	Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.	ATR CHEK1 ATM	5.70e-06	11	115	3	15364958
Pubmed	Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).	ATR CHEK1 ATM	7.58e-06	12	115	3	15149599
Pubmed	Simulated Microgravity Promotes Cell Apoptosis Through Suppressing Uev1A/TICAM/TRAF/NF-κB-Regulated Anti-Apoptosis and p53/PCNA- and ATM/ATR-Chk1/2-Controlled DNA-Damage Response Pathways.	ATR CHEK1 ATM	7.58e-06	12	115	3	26887372
Pubmed	Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains.	CYLD TNIP2 ZRANB1	9.83e-06	13	115	3	19373254
Pubmed	Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks.	ATR ATM	1.08e-05	2	115	2	19285939
Pubmed	Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes.	PJVK MYO15A	1.08e-05	2	115	2	26544938
Pubmed	Expression variations of DNA damage response genes ATM and ATR in blood cancer patients.	ATR ATM	1.08e-05	2	115	2	37338595
Pubmed	DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes.	ATR ATM	1.08e-05	2	115	2	28851706
Pubmed	Activation of ATR-Chk1 pathway facilitates EBV-mediated transformation of primary tonsillar B-cells.	ATR CHEK1	1.08e-05	2	115	2	28031537
Pubmed	Associations of ATR and CHEK1 single nucleotide polymorphisms with breast cancer.	ATR CHEK1	1.08e-05	2	115	2	23844225
Pubmed	Mangiferin induces cell cycle arrest at G2/M phase through ATR-Chk1 pathway in HL-60 leukemia cells.	ATR CHEK1	1.08e-05	2	115	2	25966274
Pubmed	Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells.	ATR CHEK1	1.08e-05	2	115	2	21383502
Pubmed	Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM).	ATR ATM	1.08e-05	2	115	2	34151669
Pubmed	Withaferin A inhibits expression of ataxia telangiectasia and Rad3-related kinase and enhances sensitivity of human breast cancer cells to cisplatin.	ATR CHEK1	1.08e-05	2	115	2	31441116
Pubmed	Inhibition of Atm and/or Atr disrupts gene silencing on the inactive X chromosome.	ATR ATM	1.08e-05	2	115	2	16213462
Pubmed	ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle.	ATR ATM	1.08e-05	2	115	2	27442013
Pubmed	Induction of ATM/ATR pathway combined with Vγ2Vδ2 T cells enhances cytotoxicity of ovarian cancer cells.	ATR ATM	1.08e-05	2	115	2	24726882
Pubmed	Targeting a non-oncogene addiction to the ATR/CHK1 axis for the treatment of small cell lung cancer.	ATR CHEK1	1.08e-05	2	115	2	29138515
Pubmed	Targeted inhibition of ATR or CHEK1 reverses radioresistance in oral squamous cell carcinoma cells with distal chromosome arm 11q loss.	ATR CHEK1	1.08e-05	2	115	2	24327542
Pubmed	Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R.	ATR CHEK1	1.08e-05	2	115	2	12738771
Pubmed	The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.	CHEK1 FBXO6	1.08e-05	2	115	2	19716789
Pubmed	rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis.	ATR ATM	1.08e-05	2	115	2	26061708
Pubmed	ATR and a Chk1-Aurora B pathway coordinate postmitotic genome surveillance with cytokinetic abscission.	ATR CHEK1	1.08e-05	2	115	2	25904336
Pubmed	Cleavage-mediated activation of Chk1 during apoptosis.	ATR CHEK1	1.08e-05	2	115	2	18550533
Pubmed	Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3'-untranslated region of ataxia telangiectasia mutated and Rad3-related (ATR) transcript.	ATR ATM	1.08e-05	2	115	2	20103595
Pubmed	Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes.	CHEK1 ATM	1.08e-05	2	115	2	9382850
Pubmed	Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.	ATR CHEK1	1.08e-05	2	115	2	26748709
Pubmed	Interplay between ATM and ATR in the regulation of common fragile site stability.	ATR ATM	1.08e-05	2	115	2	17934520
Pubmed	ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress.	ATR CHEK1	1.08e-05	2	115	2	19119425
Pubmed	Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents.	ATR ATM	1.08e-05	2	115	2	25483091
Pubmed	4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia telangiectasia mutated and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) signaling pathway.	ATR CHEK1	1.08e-05	2	115	2	23733185
Pubmed	ATM and ATR activities maintain replication fork integrity during SV40 chromatin replication.	ATR ATM	1.08e-05	2	115	2	23592994
Pubmed	Fbxo6 confers drug-sensitization to cisplatin via inhibiting the activation of Chk1 in non-small cell lung cancer.	CHEK1 FBXO6	1.08e-05	2	115	2	31140586
Pubmed	Bleomycin-induced over-replication involves sustained inhibition of mitotic entry through the ATM/ATR pathway.	ATR ATM	1.08e-05	2	115	2	19527713
Pubmed	An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication.	ATR CHEK1	1.08e-05	2	115	2	31209037
Pubmed	Replication stress activates DNA polymerase alpha-associated Chk1.	POLA1 CHEK1	1.08e-05	2	115	2	19177015
Pubmed	TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD.	CYLD TRPA1	1.08e-05	2	115	2	16500080
Pubmed	ATM and ATR signaling at a glance.	ATR ATM	1.08e-05	2	115	2	26567218
Pubmed	The nucleolus stress response is coupled to an ATR-Chk1-mediated G2 arrest.	ATR CHEK1	1.08e-05	2	115	2	23447702
Pubmed	Genetic Control of Human Infection with SARS-CoV-2.	DDX1 TMPRSS11D	1.08e-05	2	115	2	34248311
Pubmed	The zinc finger domains in U2AF26 and U2AF35 have diverse functionalities including a role in controlling translation.	U2AF1L4 U2AF1	1.08e-05	2	115	2	32116123
Pubmed	An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells.	ATR CHEK1	1.08e-05	2	115	2	12791699
Pubmed	Zygotic G2/M cell cycle arrest induced by ATM/Chk1 activation and DNA repair in mouse embryos fertilized with hydrogen peroxide-treated epididymal mouse sperm.	CHEK1 ATM	1.08e-05	2	115	2	24040138
Pubmed	Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis.	ATR ATM	1.08e-05	2	115	2	33742106
Pubmed	Expressed sequence tags identify a human isolog of the suil translation initiation factor.	EIF1B EIF1	1.08e-05	2	115	2	7904817
Pubmed	Roles of ATM and ATR in DNA double strand breaks and replication stress.	ATR ATM	1.08e-05	2	115	2	33887296
Pubmed	ATR disruption leads to chromosomal fragmentation and early embryonic lethality.	ATR ATM	1.08e-05	2	115	2	10691732
Pubmed	Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription.	ATR ATM	1.08e-05	2	115	2	31114877
Pubmed	Shift in G1-Checkpoint from ATM-Alone to a Cooperative ATM Plus ATR Regulation with Increasing Dose of Radiation.	ATR ATM	1.08e-05	2	115	2	35011623
Pubmed	Homozygous mutations in PJVK and MYO15A genes associated with non-syndromic hearing loss in Moroccan families.	PJVK MYO15A	1.08e-05	2	115	2	28964305
Pubmed	The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.	ATR ATM	1.08e-05	2	115	2	26517239
Pubmed	ATR-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damage.	ATR CHEK1	1.08e-05	2	115	2	29378956
Pubmed	DNA damage-sensing kinases mediate the mouse 2-cell embryo's response to genotoxic stress.	ATR ATM	1.08e-05	2	115	2	21593482
Pubmed	A synthetic lethal screen reveals enhanced sensitivity to ATR inhibitor treatment in mantle cell lymphoma with ATM loss-of-function.	ATR ATM	1.08e-05	2	115	2	25232030
Pubmed	ATM acts downstream of ATR in the DNA damage response signaling of bystander cells.	ATR ATM	1.08e-05	2	115	2	18757420
Pubmed	Cellular responses to the DNA strand-scission enediyne C-1027 can be independent of ATM, ATR, and DNA-PK kinases.	ATR ATM	1.08e-05	2	115	2	11927575
Pubmed	In Vivo and In Vitro Effects of ATM/ATR Signaling Pathway on Proliferation, Apoptosis, and Radiosensitivity of Nasopharyngeal Carcinoma Cells.	ATR ATM	1.08e-05	2	115	2	28820634
Pubmed	ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations.	ATR ATM	1.08e-05	2	115	2	29279380
Pubmed	ATR regulates fragile site stability.	ATR ATM	1.08e-05	2	115	2	12526805
Pubmed	ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.	ATR CHEK1	1.08e-05	2	115	2	19242509
Pubmed	Inhibition of ATR-dependent feedback activation of Chk1 sensitises cancer cells to Chk1 inhibitor monotherapy.	ATR CHEK1	1.08e-05	2	115	2	27693461
Pubmed	Investigation of switch from ATM to ATR signaling at the sites of DNA damage induced by low and high LET radiation.	ATR ATM	1.08e-05	2	115	2	24238855
Pubmed	Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex.	ATR ATM	1.08e-05	2	115	2	16474843
Pubmed	The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.	ATR ATM	1.08e-05	2	115	2	8843195
Pubmed	Viral DNA replication-dependent DNA damage response activation during BK polyomavirus infection.	ATR ATM	1.08e-05	2	115	2	25694603
Pubmed	Ataxia-Telangiectasia and RAD3-Related and Ataxia-Telangiectasia-Mutated Proteins in Epithelial Ovarian Carcinoma: Their Expression and Clinical Significance.	ATR ATM	1.08e-05	2	115	2	26124337
Pubmed	Resveratrol analogue (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl)ethenyl]-quinazoline induces G₂/M cell cycle arrest through the activation of ATM/ATR in human cervical carcinoma HeLa cells.	ATR ATM	1.08e-05	2	115	2	25812484
Pubmed	Roles of ATM and ATR-mediated DNA damage responses during lytic BK polyomavirus infection.	ATR ATM	1.08e-05	2	115	2	22952448
Pubmed	ATM regulates ATR chromatin loading in response to DNA double-strand breaks.	ATR ATM	1.08e-05	2	115	2	16461339
Pubmed	ATR localizes to the photoreceptor connecting cilium and deficiency leads to severe photoreceptor degeneration in mice.	ATR ATM	1.08e-05	2	115	2	23297361
Pubmed	ATR-Chk1 signaling inhibition as a therapeutic strategy to enhance cisplatin chemosensitivity in urothelial bladder cancer.	ATR CHEK1	1.08e-05	2	115	2	26657501
Pubmed	Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells.	CHEK1 ATM	1.08e-05	2	115	2	19401701
Pubmed	Inactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cells.	ATR ATM	1.08e-05	2	115	2	23272087
Pubmed	The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization.	ATR ATM	1.08e-05	2	115	2	27129217
Pubmed	Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants.	ATR ATM	1.08e-05	2	115	2	20368801
Pubmed	Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication.	ATR CHEK1	1.08e-05	2	115	2	21680529
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR4 FBXO11	3.71e-04	7	77	2	785
GeneFamily	Myosins, class I	MYO1G MYO1H	4.93e-04	8	77	2	1097
GeneFamily	Ubiquitin specific peptidases	CYLD USP9Y USP38	1.75e-03	56	77	3	366
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	UBR4 ITGAX TPP1 DENND4B PCOLCE2 MMP19 CPVL	8.72e-07	199	115	7	667b8b47a5b388506e3177b46747267fad8024f6
ToppCell	Tuft-tuft-4\|World / Class top	DDAH1 ZSWIM1 B4GALT5 LGALS13 CPVL EPHX3	6.09e-06	174	115	6	d6f306ebf66061bf9e9742000bfedce12d277452
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTLL5 SEMA5A CLSTN2 TFR2 EPHX3 IP6K2	7.16e-06	179	115	6	e880c507f11ce75d104593a4ca29f0295f8125e8
ToppCell	droplet-Bladder-Unstain-18m-Epithelial-bladder_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNFSF12 B4GALT5 SLC16A2 C1QTNF2 EIF1 MMP19	1.13e-05	194	115	6	ee6b5fb4e993a4c0dc556091b8fefd56bdc70d8f
ToppCell	3'_v3-Lung\|World / Manually curated celltypes from each tissue	SEMA3C FPR2 ITGAX PCOLCE2 MMP19 CPVL	1.20e-05	196	115	6	a04f8384b734ce67ec402e64bd891a6274f04744
ToppCell	distal-2-Hematologic-OLR1+_Classical_Monocyte\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MYO1G FPR2 ITGAX TNFSF8 MMP19 CPVL	1.27e-05	198	115	6	43179d92e45b14f6f3d63949a9d88c2c7531f7d1
ToppCell	Bronchus_Control_(B.)-Immune-TX-MoAM-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	MYO1G FPR2 ITGAX TPP1 MMP19 CPVL	1.35e-05	200	115	6	fe7f8b04067b6680b69c8523f0fa514ef97207e2
ToppCell	Biopsy_Other_PF-Immune-Macrophages\|Biopsy_Other_PF / Sample group, Lineage and Cell type	FPR2 ITGAX TPP1 PCOLCE2 MMP19 CPVL	1.35e-05	200	115	6	9ff5f0371aac2ab528b581fe979a1522579b8b84
Drug	Aphidicolin	ATR POLA1 CHEK1 ATM	1.30e-06	17	113	4	ctd:D016590
Drug	Pralidoxime chloride [51-15-0]; Down 200; 23.2uM; HL60; HT_HG-U133A	CENPB UBR4 TFR2 MMP25 TPP1 AP1G2 SMPD2 MMP19	6.18e-06	196	113	8	3066_DN
Disease	ataxia telangiectasia (implicated_via_orthology)	ATR ATM	1.38e-05	2	110	2	DOID:12704 (implicated_via_orthology)
Disease	female breast cancer (is_implicated_in)	RTEL1 ATM	3.80e-04	8	110	2	DOID:0050671 (is_implicated_in)
Disease	cortical surface area measurement	ACSL6 SEMA3C NPR2 DDAH1 SEMA5A SRPK2 USP38 IMMP1L MED23 LNX1 CPVL RPS6KL1 FBN3 IP6K2	4.81e-04	1345	110	14	EFO_0010736
Disease	nasopharynx carcinoma (is_marker_for)	ATR ATM SPEN	5.58e-04	43	110	3	DOID:9261 (is_marker_for)
Disease	triacylglycerol 58:12 measurement	TRIP12 LNX1	8.87e-04	12	110	2	EFO_0010439
Disease	HbA1c measurement	CUX2 ADAMTS13 PFKL ITGAX TFR2 KCNQ1 PCOLCE2 MYO15A CPVL	9.71e-04	675	110	9	EFO_0004541
Disease	Myopia	GRIA4 SIX6	1.40e-03	15	110	2	C0027092
Disease	anthranilic acid measurement	KCNQ1 LNX1	1.60e-03	16	110	2	EFO_0010460
Disease	Benign neoplasm of stomach	ATR ATM	1.81e-03	17	110	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	ATR ATM	1.81e-03	17	110	2	C0496905
Disease	Carcinoma in situ of stomach	ATR ATM	1.81e-03	17	110	2	C0154060
Disease	melanoma	GOPC UBR4 CPT1C ATM EPHX3	2.41e-03	248	110	5	C0025202
Disease	Stomach Carcinoma	ATR ATM	2.76e-03	21	110	2	C0699791
Disease	nose morphology measurement, mouth morphology measurement	KCNQ1 FBN3	2.76e-03	21	110	2	EFO_0007843, EFO_0007955
Disease	glioma	RTEL1 GRIA4	3.03e-03	22	110	2	EFO_0005543
Disease	unipolar depression, response to selective serotonin reuptake inhibitor	RASSF10 CPT1C	3.60e-03	24	110	2	EFO_0003761, EFO_0005658

Protein segments in the cluster

Peptide	Gene	Start	Entry
LYQTRGQLHVLRVGN	UPK3BL1	126	B0FP48
NVVKFYGHRREGNIQ	CHEK1	66	O14757
QAFQETRGYIQARLH	ADCY6	316	O43306
QNGRNGEIRVAFVLY	ADGRL3	721	Q9HAR2
IGGAQELHAYSVRRL	AP1G2	446	O75843
EQATHFIRANGRIVY	NPR2	211	P20594
GTEDYIHIRIQQRNG	EIF1B	26	O60739
IRTGQGSIYLQRVQH	DNHD1	486	Q96M86
IGQRVFGHYVLGLSQ	CUX2	571	O14529
GVYRVRIAHQHFIQE	CLSTN2	851	Q9H4D0
RIRYVIVRGNEQGFF	FBN3	2736	Q75N90
HRGEVQFLGRYALLR	B4GALT5	331	O43286
GVRYILFQHGGRDTQ	FBXO6	226	Q9NRD1
LFTHLAVRIGGRYVV	ADAMTS13	591	Q76LX8
LIHQEGNRLYREGHV	AIP	181	O00170
GHYFQRRLGLANGVV	SLC16A2	221	P36021
RRHGVNYVQDTYLVG	RASSF10	266	A6NK89
LSRHFYGIQRGDIVI	IMMP1L	56	Q96LU5
IIRYAIGVGLAFQNR	ITGAX	281	P20702
RHIAVLQAEVYGARL	GOPC	191	Q9HD26
EIGTHYLRGVNNARQ	KIAA0895L	281	Q68EN5
RLFIHGVILADQGTY	OBSL1	1506	O75147
QVRVVQAAYARHRDG	MMP25	366	Q9NPA2
LARTHVQGRVYNFLE	KCNQ1	101	P51787
THRVRLYHIQGIEGQ	MAN2A1	846	Q16706
QFFHNGRYLRRELLG	IP6K2	291	Q9UHH9
LHGARENIFGNYIVQ	MYO15A	2101	Q9UKN7
GGLLQDVHVRSIFYQ	MAPK15	106	Q8TD08
LYVFVGQDFRERLIH	FPR2	301	P25090
AFNNDVVQRRHYRIG	IQSEC2	746	Q5JU85
QGYRILGEFLQEKHR	KIAA2026	81	Q5HYC2
DRNLIQYVHLGQEGI	FREM2	1376	Q5SZK8
GLVHNGQYRIRTFDA	C1QTNF2	211	Q9BXJ5
YIRQAGDFHQVIIRG	CPVL	431	Q9H3G5
KQNYVHRIGRVGRAE	DDX1	596	Q92499
GTEDYIHIRIQQRNG	EIF1	26	P41567
GLTGNVQFDHYGRRV	GRIA4	356	P48058
AGRIGELQGHYLFVQ	PCSK7	86	Q16549
YRGVNLRIIAAHEVG	MMP19	201	Q99542
EGRRAAAYNLVQHGI	PFKL	96	P17858
LYRHFQIPRVVQEGD	PEX6	341	Q13608
DHINQIGYRVLERIG	MED23	801	Q9ULK4
VFIFNVLDGGVAYRH	LNX1	406	Q8TBB1
GRHRGVRAVQQQLAY	GLI2	1381	P10070
FQGVGRLGHILEYNT	KLHL7	536	Q8IXQ5
VDVYNGHANGQRIGR	PCOLCE2	91	Q9UKZ9
YQGRFAVDPRIITHQ	HELZ	1216	P42694
GSFHIRRGEVGIYQV	ITGB4	396	P16144
ATGFLGRYVVNHLGR	NDUFA9	61	Q16795
GHNIYGFELEVLLQR	POLA1	636	P09884
VHQIRQLFQYQEGVR	PCF11	686	O94913
GLYRAQAELQHVLGR	SMPD2	381	O60906
EIKVNGIRIYGFVHR	LGALS13	101	Q9UHV8
SGQGVDRHLFALYIV	CPT1C	646	Q8TCG5
LLVRAARHYEGAGQI	FCSK	666	Q8N0W3
ARHYEGAGQILIRQA	FCSK	671	Q8N0W3
HVRNLLSAYGEVGRV	ABT1	61	Q9ULW3
IVGYILGLGDRHVQN	ATM	2861	Q13315
LRIGEHYQQVFNGLS	ATR	1081	Q13535
QGDLIRYIVLHFGRS	ATR	2061	Q13535
ERGVVQQVKGHYRQA	CENPB	326	P07199
NAVVQILRLHGVRDY	GLRX5	71	Q86SX6
VLDNRIYVLGGRSHN	KLHL22	541	Q53GT1
RRNRIHSGKQVGVYF	FBXO11	631	Q86XK2
VQSQEQGRHLRGLLY	FRMPD3	721	Q5JV73
DNGRVRIQHFYNVGQ	FRRS1L	166	Q9P0K9
GHREIARYLLEQGAQ	FEM1A	161	Q9BSK4
QSRFHVVAVDLRGYG	EPHX3	121	Q9H6B9
TGLHLQRGIYREILF	DENND4B	1421	O75064
AVGGHDQFVRIYDQR	DCAF8L1	351	A6NGE4
VAVFHGRNFLRGILE	CELSR3	2446	Q9NYQ7
IGQYIQDRSVGHSRI	CYLD	46	Q9NQC7
LGYVIHGRINVQFNN	ENPP7	336	Q6UWV6
ARAERQHQLYVGVLG	DDAH1	41	O94760
FIQVNRRGESIYLHN	GARIN2	51	Q8N9W8
GRVIRHRQDYGAVFL	RTEL1	696	Q9NZ71
LYQTRGQLHVLRVGN	UPK3BL2	126	E5RIL1
RVNAADGRYHVLFLG	SEMA3C	436	Q99985
RNEGGVVVRFFEQHL	TMEM200A	106	Q86VY9
INRGYFARVHGVSQL	LCMT1	66	Q9UIC8
NQYQTRVIHDGARLF	RNF32	171	Q9H0A6
ARAIVAFHGGNYREL	SIX6	56	O95475
VEFAIRVYRRIGNVG	WDR19	691	Q8NEZ3
ILRQTLFRYQGHVGA	PSMB10	121	P40306
GFFILLRIFHRGVQE	ABCC12	961	Q96J65
RSFVIDHQRLSGQGY	SPTLC1	321	O15269
VNISDNGGHYEQRFR	SEMA5A	716	Q13591
IGDVFNGRYHVVRKL	SRPK3	71	Q9UPE1
HEVTIFVRRGGPNYQ	ACLY	371	P53396
FERVIQSVVYCHGGR	ACSL6	326	Q9UKU0
RHGVYGLQRNLLVEN	TRIM63	86	Q969Q1
EYVRGLHAQLRGLQI	TNIP2	236	Q8NFZ5
YAGHTVPELRQGQVR	TMPRSS11D	316	O60235
LHGVRYQDGNLVIQF	TNFSF8	121	P32971
GQAFILGSQLIEHYR	ZNF565	521	Q8N9K5
GYVRGQTLNVNRLLH	TSR1	276	Q2NL82
IILRFGEEHGYSRQL	TRPA1	216	O75762
YHDLRNIFQRFGEIV	SPEN	451	Q96T58
VSLYGRRGNHIVNDV	PJVK	86	Q0ZLH3
GVLFLQFGEETRRVH	SRCIN1	181	Q9C0H9
NILRLIYQGRFLHGN	UBL3	56	O95164
VKIGDLFNGRYHVIR	SRPK2	71	P78362
YRGFFHGVREIVREQ	SLC25A1	161	P53007
AHVYLEQIRNRVALG	RPS6KL1	26	Q9Y6S9
GDHLVGNVYVKFRRE	U2AF1	106	Q01081
YNIGVLRHLQVIFGH	USP9Y	1641	O00507
GDHLVGNVYVKFRRE	U2AF1L4	106	Q8WU68
FQRQVGHQVLEAYAR	USP38	56	Q8NB14
KYNQGVVEHFQRGLR	PLCH1	1391	Q4KWH8
YNRQIGEFIVTRAGL	TNFSF12	146	O43508
RVQLEGHLARAVYFA	ZSWIM1	101	Q9BR11
NSGNVRHRLQFYIGE	TRIP12	1336	Q14669
RRAGGEHYQNFQLLG	UBR4	396	Q5T4S7
YGDVVLRHIGNLNEF	TFR2	646	Q9UP52
VGYTLVHLAIRFQRQ	ZRANB1	311	Q9UGI0
RILAHQLGDFIIVYN	TTLL5	746	Q6EMB2
RLYQQHGAGLFDVTR	TPP1	506	O14773
VGERNFHAFYQLLRG	MYO1G	196	B0I1T2
RVVYQNEGERNFHIF	MYO1H	191	Q8N1T3