Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	ADGRE5 THBS1 FAT2 LTBP2 STAB2 PROZ FLG2 ADGRE2 MEGF6 MEGF8 LRP1B SVEP1	1.51e-08	749	40	12	GO:0005509
GeneOntologyMolecularFunction	extracellular matrix structural constituent	FRAS1 THBS1 LTBP2 VWF SSPOP MUC5AC MUC6	8.41e-08	188	40	7	GO:0005201
GeneOntologyMolecularFunction	structural molecule activity	KRTAP29-1 FRAS1 THBS1 LTBP2 VWF FLG2 SSPOP MUC5AC MUC6	5.28e-05	891	40	9	GO:0005198
GeneOntologyMolecularFunction	glycosaminoglycan binding	ADGRE5 THBS1 LTBP2 STAB2 ADGRE2	1.88e-04	268	40	5	GO:0005539
GeneOntologyMolecularFunction	chondroitin sulfate binding	ADGRE5 ADGRE2	2.13e-04	11	40	2	GO:0035374
GeneOntologyMolecularFunction	integrin binding	THBS1 VWF ITGB4 SVEP1	4.07e-04	175	40	4	GO:0005178
GeneOntologyMolecularFunction	extracellular matrix binding	THBS1 LTBP2 ZAN	4.20e-04	73	40	3	GO:0050840
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	STAB2 LRP1B	4.61e-04	16	40	2	GO:0005041
GeneOntologyMolecularFunction	low-density lipoprotein particle binding	THBS1 STAB2	5.87e-04	18	40	2	GO:0030169
GeneOntologyMolecularFunction	cargo receptor activity	STAB2 LRP1B SCARF2	6.56e-04	85	40	3	GO:0038024
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	STAB2 LRP1B	8.02e-04	21	40	2	GO:0030228
GeneOntologyMolecularFunction	scavenger receptor activity	STAB2 SCARF2	1.33e-03	27	40	2	GO:0005044
GeneOntologyMolecularFunction	lipoprotein particle binding	THBS1 STAB2	2.23e-03	35	40	2	GO:0071813
GeneOntologyMolecularFunction	protein-lipid complex binding	THBS1 STAB2	2.23e-03	35	40	2	GO:0071814
GeneOntologyMolecularFunction	growth factor binding	THBS1 LTBP2 ITGB4	3.74e-03	156	40	3	GO:0019838
GeneOntologyMolecularFunction	sulfur compound binding	ADGRE5 THBS1 LTBP2 ADGRE2	3.88e-03	323	40	4	GO:1901681
GeneOntologyCellularComponent	extracellular matrix	ADAMTS20 FRAS1 THBS1 MUC5B LTBP2 VWF ZAN MEGF6 PLXDC2 SSPOP MUC5AC ITGB4 MUC6 SVEP1	1.26e-11	656	41	14	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	ADAMTS20 FRAS1 THBS1 MUC5B LTBP2 VWF ZAN MEGF6 PLXDC2 SSPOP MUC5AC ITGB4 MUC6 SVEP1	1.31e-11	658	41	14	GO:0030312
GeneOntologyCellularComponent	collagen-containing extracellular matrix	ADAMTS20 FRAS1 THBS1 LTBP2 VWF MEGF6 PLXDC2 SSPOP ITGB4	6.88e-07	530	41	9	GO:0062023
GeneOntologyCellularComponent	Golgi lumen	MUC5B PROZ MUC5AC MUC6	6.10e-05	109	41	4	GO:0005796
MousePheno	abnormal conjunctiva goblet cell morphology	THBS1 MUC5AC	3.23e-05	4	33	2	MP:0012164
MousePheno	complete cleft palate	SPRY2 FRAS1	5.38e-05	5	33	2	MP:0021213
MousePheno	abnormal conjunctival epithelium morphology	THBS1 MUC5AC	1.13e-04	7	33	2	MP:0004481
Domain	EGF_3	ADGRE5 THBS1 FAT2 LTBP2 STAB2 PROZ ZAN ADGRE2 MEGF6 MEGF8 SSPOP LRP1B SCARF2 MEGF11 ATRNL1 SVEP1 TMEFF2	3.21e-22	235	41	17	PS50026
Domain	EGF	ADGRE5 FRAS1 THBS1 FAT2 LTBP2 STAB2 PROZ ZAN ADGRE2 MEGF6 MEGF8 LRP1B SCARF2 MEGF11 ATRNL1 SVEP1 TMEFF2	3.21e-22	235	41	17	SM00181
Domain	EGF-like_dom	ADGRE5 FRAS1 THBS1 FAT2 LTBP2 STAB2 PROZ ZAN ADGRE2 MEGF6 MEGF8 LRP1B SCARF2 MEGF11 ATRNL1 SVEP1 TMEFF2	8.73e-22	249	41	17	IPR000742
Domain	EGF_1	THBS1 FAT2 LTBP2 STAB2 PROZ ZAN ADGRE2 MEGF6 MEGF8 SSPOP LRP1B SCARF2 ITGB4 MEGF11 ATRNL1 SVEP1 TMEFF2	1.32e-21	255	41	17	PS00022
Domain	EGF_2	THBS1 FAT2 LTBP2 STAB2 PROZ ZAN ADGRE2 MEGF6 MEGF8 SSPOP LRP1B SCARF2 ITGB4 MEGF11 ATRNL1 SVEP1 TMEFF2	2.56e-21	265	41	17	PS01186
Domain	EGF-like_CS	THBS1 FAT2 LTBP2 STAB2 PROZ ZAN ADGRE2 MEGF6 MEGF8 LRP1B SCARF2 ITGB4 MEGF11 ATRNL1 SVEP1 TMEFF2	1.01e-19	261	41	16	IPR013032
Domain	EGF_CA	ADGRE5 THBS1 FAT2 LTBP2 STAB2 PROZ ADGRE2 MEGF6 MEGF8 LRP1B SVEP1	1.56e-15	122	41	11	SM00179
Domain	EGF-like_Ca-bd_dom	ADGRE5 THBS1 FAT2 LTBP2 STAB2 PROZ ADGRE2 MEGF6 MEGF8 LRP1B SVEP1	1.88e-15	124	41	11	IPR001881
Domain	EGF_extracell	LTBP2 STAB2 MEGF6 LRP1B SCARF2 ITGB4 MEGF11 ATRNL1 SVEP1	6.29e-15	60	41	9	IPR013111
Domain	EGF_2	LTBP2 STAB2 MEGF6 LRP1B SCARF2 ITGB4 MEGF11 ATRNL1 SVEP1	6.29e-15	60	41	9	PF07974
Domain	VWC_out	FRAS1 MUC5B VWF ZAN SSPOP MUC5AC MUC6	7.07e-15	19	41	7	SM00215
Domain	VWF_dom	FRAS1 THBS1 MUC5B VWF ZAN SSPOP MUC5AC MUC6	2.92e-14	42	41	8	IPR001007
Domain	TIL	MUC5B VWF ZAN SSPOP MUC5AC MUC6	6.99e-14	12	41	6	PF01826
Domain	C8	MUC5B VWF ZAN SSPOP MUC5AC MUC6	6.99e-14	12	41	6	PF08742
Domain	Unchr_dom_Cys-rich	MUC5B VWF ZAN SSPOP MUC5AC MUC6	1.30e-13	13	41	6	IPR014853
Domain	C8	MUC5B VWF ZAN SSPOP MUC5AC MUC6	1.30e-13	13	41	6	SM00832
Domain	TIL_dom	MUC5B VWF ZAN SSPOP MUC5AC MUC6	2.26e-13	14	41	6	IPR002919
Domain	VWFD	MUC5B VWF ZAN SSPOP MUC5AC MUC6	6.02e-13	16	41	6	PS51233
Domain	VWD	MUC5B VWF ZAN SSPOP MUC5AC MUC6	6.02e-13	16	41	6	SM00216
Domain	VWF_type-D	MUC5B VWF ZAN SSPOP MUC5AC MUC6	6.02e-13	16	41	6	IPR001846
Domain	VWD	MUC5B VWF ZAN SSPOP MUC5AC MUC6	6.02e-13	16	41	6	PF00094
Domain	Growth_fac_rcpt_	ADGRE5 FRAS1 LTBP2 STAB2 ADGRE2 MEGF6 MEGF8 LRP1B SCARF2 SVEP1	1.11e-12	156	41	10	IPR009030
Domain	VWFC_1	FRAS1 THBS1 MUC5B VWF ZAN SSPOP MUC5AC	1.14e-12	36	41	7	PS01208
Domain	VWC	FRAS1 THBS1 MUC5B VWF ZAN SSPOP MUC5AC	1.72e-12	38	41	7	SM00214
Domain	VWFC_2	FRAS1 THBS1 MUC5B VWF ZAN SSPOP MUC5AC	1.72e-12	38	41	7	PS50184
Domain	EGF	FAT2 LTBP2 STAB2 PROZ ZAN MEGF6 LRP1B SVEP1 TMEFF2	6.33e-12	126	41	9	PF00008
Domain	EGF_CA	ADGRE5 THBS1 LTBP2 ADGRE2 MEGF6 MEGF8 LRP1B SVEP1	1.22e-11	86	41	8	PF07645
Domain	ASX_HYDROXYL	ADGRE5 LTBP2 PROZ ADGRE2 MEGF6 MEGF8 LRP1B SVEP1	4.20e-11	100	41	8	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	ADGRE5 LTBP2 PROZ ADGRE2 MEGF6 MEGF8 LRP1B SVEP1	6.73e-11	106	41	8	IPR000152
Domain	EGF_Lam	STAB2 MEGF6 MEGF8 SCARF2 MEGF11 ATRNL1	1.18e-10	35	41	6	SM00180
Domain	Laminin_EGF	STAB2 MEGF6 MEGF8 SCARF2 MEGF11 ATRNL1	2.00e-10	38	41	6	IPR002049
Domain	EGF_Ca-bd_CS	ADGRE5 LTBP2 ADGRE2 MEGF6 MEGF8 LRP1B SVEP1	1.59e-09	97	41	7	IPR018097
Domain	EGF_CA	ADGRE5 LTBP2 ADGRE2 MEGF6 MEGF8 LRP1B SVEP1	1.84e-09	99	41	7	PS01187
Domain	Cys_knot_C	MUC5B VWF SSPOP MUC5AC MUC6	2.04e-09	25	41	5	IPR006207
Domain	CTCK_2	MUC5B VWF SSPOP MUC5AC MUC6	2.04e-09	25	41	5	PS01225
Domain	VWC	FRAS1 THBS1 MUC5B VWF MUC5AC	3.75e-09	28	41	5	PF00093
Domain	CTCK_1	MUC5B VWF SSPOP MUC5AC	5.98e-08	18	41	4	PS01185
Domain	CT	MUC5B VWF MUC5AC MUC6	1.42e-07	22	41	4	SM00041
Domain	Laminin_EGF	MEGF6 MEGF8 SCARF2 MEGF11	9.96e-07	35	41	4	PF00053
Domain	PSI	MEGF8 PLXDC2 ITGB4 ATRNL1	2.55e-06	44	41	4	IPR016201
Domain	PSI	MEGF8 PLXDC2 ITGB4 ATRNL1	3.05e-06	46	41	4	SM00423
Domain	GPCR_2_CD97	ADGRE5 ADGRE2	4.70e-06	2	41	2	IPR003056
Domain	EMI	MEGF6 SSPOP MEGF11	6.54e-06	17	41	3	PS51041
Domain	hEGF	MEGF6 MEGF11 SVEP1	3.10e-05	28	41	3	PF12661
Domain	EGF_LAM_2	STAB2 MEGF8 ATRNL1	3.83e-05	30	41	3	PS50027
Domain	EGF_LAM_1	STAB2 MEGF8 ATRNL1	3.83e-05	30	41	3	PS01248
Domain	Plexin_repeat	MEGF8 PLXDC2 ATRNL1	4.66e-05	32	41	3	IPR002165
Domain	PSI	MEGF8 PLXDC2 ATRNL1	4.66e-05	32	41	3	PF01437
Domain	WxxW_domain	MUC5B MUC5AC	7.01e-05	6	41	2	IPR025155
Domain	Mucin2_WxxW	MUC5B MUC5AC	7.01e-05	6	41	2	PF13330
Domain	ConA-like_dom	THBS1 FAT2 ZAN ITGB4 SVEP1	1.13e-04	219	41	5	IPR013320
Domain	Calx_beta	FRAS1 ITGB4	1.31e-04	8	41	2	SM00237
Domain	-	MEGF8 ATRNL1 KLHL22	1.59e-04	48	41	3	2.120.10.80
Domain	Calx_beta	FRAS1 ITGB4	1.68e-04	9	41	2	IPR003644
Domain	PSI_integrin	MEGF8 ITGB4	1.68e-04	9	41	2	PF17205
Domain	Calx-beta	FRAS1 ITGB4	1.68e-04	9	41	2	PF03160
Domain	Integin_beta_N	MEGF8 ITGB4	1.68e-04	9	41	2	IPR033760
Domain	CUB	MEGF8 ATRNL1 PDGFD	1.69e-04	49	41	3	PF00431
Domain	CUB	MEGF8 ATRNL1 PDGFD	1.79e-04	50	41	3	SM00042
Domain	-	MEGF8 ATRNL1 PDGFD	2.01e-04	52	41	3	2.60.120.290
Domain	CUB	MEGF8 ATRNL1 PDGFD	2.13e-04	53	41	3	PS01180
Domain	Kelch-typ_b-propeller	MEGF8 ATRNL1 KLHL22	2.38e-04	55	41	3	IPR015915
Domain	-	STAB2 SVEP1	2.55e-04	11	41	2	2.40.155.10
Domain	GFP-like	STAB2 SVEP1	2.55e-04	11	41	2	IPR023413
Domain	CUB_dom	MEGF8 ATRNL1 PDGFD	2.65e-04	57	41	3	IPR000859
Domain	EGF_3	STAB2 MEGF8	3.06e-04	12	41	2	PF12947
Domain	EGF_dom	STAB2 MEGF8	3.06e-04	12	41	2	IPR024731
Domain	TSP_1	ADAMTS20 THBS1 SSPOP	3.56e-04	63	41	3	PF00090
Domain	TSP1	ADAMTS20 THBS1 SSPOP	3.90e-04	65	41	3	SM00209
Domain	TSP1_rpt	ADAMTS20 THBS1 SSPOP	3.90e-04	65	41	3	IPR000884
Domain	TSP1	ADAMTS20 THBS1 SSPOP	3.90e-04	65	41	3	PS50092
Domain	Glyco_hormone_CN	MUC5B MUC5AC	4.85e-04	15	41	2	IPR006208
Domain	Cys_knot	MUC5B MUC5AC	4.85e-04	15	41	2	PF00007
Domain	Kelch_1	MEGF8 ATRNL1 KLHL22	4.85e-04	70	41	3	PF01344
Domain	Kelch_1	MEGF8 ATRNL1 KLHL22	4.85e-04	70	41	3	IPR006652
Domain	EMI_domain	MEGF6 MEGF11	5.53e-04	16	41	2	IPR011489
Domain	-	VWF ITGB4 SVEP1	5.71e-04	74	41	3	3.40.50.410
Domain	VWFA	VWF ITGB4 SVEP1	7.71e-04	82	41	3	PS50234
Domain	VWA	VWF ITGB4 SVEP1	8.27e-04	84	41	3	SM00327
Domain	-	THBS1 FAT2 SVEP1	1.18e-03	95	41	3	2.60.120.200
Domain	VWF_A	VWF ITGB4 SVEP1	1.33e-03	99	41	3	IPR002035
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS20 THBS1 MUC5B SSPOP MUC5AC MUC6	6.73e-09	68	31	6	M27303
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS20 THBS1 MUC5B SSPOP MUC5AC MUC6	1.17e-07	109	31	6	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS20 THBS1 MUC5B SSPOP MUC5AC MUC6	1.30e-07	111	31	6	M27416
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	ADAMTS20 THBS1 MUC5B SSPOP MUC5AC MUC6	5.86e-07	143	31	6	M27275
Pathway	REACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC	MUC5B MUC5AC MUC6	5.29e-06	16	31	3	M27410
Pathway	REACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS	MUC5B MUC5AC MUC6	6.41e-06	17	31	3	M27412
Pathway	REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS	MUC5B MUC5AC MUC6	1.25e-05	21	31	3	MM15706
Pathway	REACTOME_DISEASES_OF_METABOLISM	ADAMTS20 THBS1 MUC5B SSPOP MUC5AC MUC6	1.49e-05	250	31	6	M27554
Pathway	REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS	MUC5B MUC5AC MUC6	1.66e-05	23	31	3	M556
Pathway	REACTOME_DECTIN_2_FAMILY	MUC5B MUC5AC MUC6	2.42e-05	26	31	3	M27483
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS20 THBS1 SSPOP	8.34e-05	39	31	3	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS20 THBS1 SSPOP	8.34e-05	39	31	3	MM15165
Pathway	REACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY	MEGF6 ITGB4	1.67e-04	9	31	2	MM15117
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	THBS1 LTBP2 VWF MEGF6 ITGB4	2.27e-04	258	31	5	MM14572
Pathway	REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS	MUC5B MUC5AC MUC6	3.03e-04	60	31	3	MM15636
Pathway	REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS	MUC5B MUC5AC MUC6	3.34e-04	62	31	3	M546
Pathway	REACTOME_LAMININ_INTERACTIONS	MEGF6 ITGB4	4.83e-04	15	31	2	MM14922
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	ADAMTS20 THBS1 MUC5B PROZ MEGF6 USP3 SSPOP MUC5AC MUC6 KLHL22	5.34e-04	1389	31	10	MM15307
Pathway	WP_FOCAL_ADHESION	THBS1 VWF ITGB4 PDGFD	7.13e-04	187	31	4	MM15913
Pathway	KEGG_ECM_RECEPTOR_INTERACTION	THBS1 VWF ITGB4	8.13e-04	84	31	3	M7098
Pathway	KEGG_FOCAL_ADHESION	THBS1 VWF ITGB4 PDGFD	8.99e-04	199	31	4	M7253
Pathway	WP_FOCAL_ADHESION	THBS1 VWF ITGB4 PDGFD	8.99e-04	199	31	4	M39402
Pathway	WP_GPCRS_CLASS_B_SECRETINLIKE	ADGRE5 ADGRE2	1.25e-03	24	31	2	MM15992
Pathway	WP_GPCRS_CLASS_B_SECRETINLIKE	ADGRE5 ADGRE2	1.25e-03	24	31	2	M39643
Pathway	REACTOME_SYNDECAN_INTERACTIONS	THBS1 ITGB4	1.59e-03	27	31	2	M27217
Pathway	WP_22Q112_COPY_NUMBER_VARIATION_SYNDROME	VWF SCARF2 KLHL22	2.85e-03	130	31	3	M39787
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	ADAMTS20 THBS1 MUC5B PROZ USP3 SSPOP MUC5AC MUC6 KLHL22	3.50e-03	1475	31	9	M19806
Pathway	REACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS	MUC5B MUC5AC MUC6	3.52e-03	140	31	3	M27484
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	THBS1 LTBP2 VWF ITGB4	4.02e-03	300	31	4	M610
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING	THBS1 VWF ITGB4 PDGFD	4.12e-03	302	31	4	M39719
Pubmed	Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.	MUC5B MUC5AC MUC6	7.04e-09	4	43	3	17471237
Pubmed	The mouse secreted gel-forming mucin gene cluster.	MUC5B MUC5AC MUC6	7.04e-09	4	43	3	14984930
Pubmed	Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.	MUC5B MUC5AC MUC6	7.04e-09	4	43	3	29869461
Pubmed	Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.	MUC5B MUC5AC MUC6	7.04e-09	4	43	3	23807779
Pubmed	Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.	MUC5B MUC5AC MUC6	7.04e-09	4	43	3	12676567
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	THBS1 SSPOP MUC5AC MUC6 ATRNL1	2.78e-08	71	43	5	33541421
Pubmed	Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.	MUC5B MUC5AC MUC6	3.51e-08	6	43	3	19110483
Pubmed	Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.	FAT2 MEGF6 MEGF8	1.47e-07	9	43	3	9693030
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	ADAMTS20 FRAS1 THBS1 SSPOP	1.22e-06	64	43	4	22261194
Pubmed	Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.	MUC5B MUC5AC MUC6	1.42e-06	18	43	3	18834073
Pubmed	Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5).	MUC5B MUC5AC	1.49e-06	2	43	2	7513696
Pubmed	Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.	MUC5B MUC5AC	1.49e-06	2	43	2	34058148
Pubmed	Relationship between thrombospondin gene variations, von Willebrand factor levels and the risk of coronary heart disease in an older population.	THBS1 VWF	1.49e-06	2	43	2	21518247
Pubmed	The role of THBS1 and PDGFD in the immune microenvironment of Helicobacter pylori-associated gastric cancer.	THBS1 PDGFD	1.49e-06	2	43	2	38705811
Pubmed	The association between MUC5AC and MUC5B genes expression and remodeling progression in severe neutrophilic asthma: A direct relationship.	MUC5B MUC5AC	1.49e-06	2	43	2	37146737
Pubmed	MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions.	MUC5B MUC5AC	1.49e-06	2	43	2	14988081
Pubmed	Differential role of CD97 in interleukin-8-induced and granulocyte-colony stimulating factor-induced hematopoietic stem and progenitor cell mobilization.	ADGRE5 ADGRE2	1.49e-06	2	43	2	18326527
Pubmed	Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions.	MUC5B MUC5AC	1.49e-06	2	43	2	15563276
Pubmed	The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic rhinosinusitis and nasal polyposis.	MUC5B MUC5AC	1.49e-06	2	43	2	17621824
Pubmed	Muc5b is required for airway defence.	MUC5B MUC5AC	1.49e-06	2	43	2	24317696
Pubmed	Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells.	MUC5B MUC5AC	1.49e-06	2	43	2	22391959
Pubmed	C-Mannosylation of MUC5AC and MUC5B Cys subdomains.	MUC5B MUC5AC	1.49e-06	2	43	2	14718370
Pubmed	Thrombospondin-1 in von Willebrand factor function.	THBS1 VWF	1.49e-06	2	43	2	18855616
Pubmed	Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.	MUC5B MUC5AC	1.49e-06	2	43	2	35776514
Pubmed	Improved antibacterial host defense and altered peripheral granulocyte homeostasis in mice lacking the adhesion class G protein receptor CD97.	ADGRE5 ADGRE2	1.49e-06	2	43	2	17158902
Pubmed	Contradictory Role of CD97 in Basal and Tumor Necrosis Factor-Induced Osteoclastogenesis In Vivo.	ADGRE5 ADGRE2	1.49e-06	2	43	2	26663852
Pubmed	The role of the RGD motif in CD97/ADGRE5-and EMR2/ADGRE2-modulated tumor angiogenesis.	ADGRE5 ADGRE2	1.49e-06	2	43	2	31594642
Pubmed	The ocular surface phenotype of Muc5ac and Muc5b null mice.	MUC5B MUC5AC	1.49e-06	2	43	2	24327612
Pubmed	Mucin production during prenatal and postnatal murine lung development.	MUC5B MUC5AC	1.49e-06	2	43	2	21653907
Pubmed	Clinicopathological features of superficial non-ampurally duodenal epithelial tumor; gastric phenotype of histology correlates to higher malignant potency.	MUC5AC MUC6	1.49e-06	2	43	2	28321513
Pubmed	Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs.	MUC5AC MUC6	1.49e-06	2	43	2	9422745
Pubmed	MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium.	MUC5B MUC5AC	1.49e-06	2	43	2	36427316
Pubmed	Skeletal muscle expression of the adhesion-GPCR CD97: CD97 deletion induces an abnormal structure of the sarcoplasmatic reticulum but does not impair skeletal muscle function.	ADGRE5 ADGRE2	1.49e-06	2	43	2	24949957
Pubmed	Gel-forming mucins form distinct morphologic structures in airways.	MUC5B MUC5AC	1.49e-06	2	43	2	28607090
Pubmed	Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas.	MUC5AC MUC6	1.49e-06	2	43	2	12360467
Pubmed	CD97 is differentially expressed on murine hematopoietic stem-and progenitor-cells.	ADGRE5 ADGRE2	1.49e-06	2	43	2	18603564
Pubmed	Mucin deficiency causes functional and structural changes of the ocular surface.	MUC5B MUC5AC	1.49e-06	2	43	2	23272068
Pubmed	Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration.	ADGRE5 ADGRE2	1.49e-06	2	43	2	18941248
Pubmed	Muc5b is mainly expressed and sialylated in the nasal olfactory epithelium whereas Muc5ac is exclusively expressed and fucosylated in the nasal respiratory epithelium.	MUC5B MUC5AC	1.49e-06	2	43	2	31030254
Pubmed	Younger patients with COME are more likely to have mucoid middle ear fluid containing mucin MUC5B.	MUC5B MUC5AC	1.49e-06	2	43	2	27729120
Pubmed	The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense.	ADGRE5 ADGRE2	1.49e-06	2	43	2	14707087
Pubmed	Overexpression of CD97 in intestinal epithelial cells of transgenic mice attenuates colitis by strengthening adherens junctions.	ADGRE5 ADGRE2	1.49e-06	2	43	2	20084281
Pubmed	The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium.	MUC5B MUC5AC	1.49e-06	2	43	2	23527003
Pubmed	Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion.	MUC5B MUC5AC	1.49e-06	2	43	2	16540890
Pubmed	De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.	MUC5B MUC5AC	1.49e-06	2	43	2	36111525
Pubmed	Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease.	ADGRE5 ADGRE2	1.49e-06	2	43	2	20167235
Pubmed	Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma.	MUC5B MUC5AC	1.49e-06	2	43	2	27845589
Pubmed	The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans.	ADGRE5 ADGRE2	1.49e-06	2	43	2	12829604
Pubmed	CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD.	ADGRE5 ADGRE2	1.49e-06	2	43	2	34314469
Pubmed	Role of thrombospondin-1 in control of von Willebrand factor multimer size in mice.	THBS1 VWF	1.49e-06	2	43	2	14981081
Pubmed	G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody.	ADGRE5 ADGRE2	1.49e-06	2	43	2	31969668
Pubmed	Putative alternative trans-splicing of leukocyte adhesion-GPCR pre-mRNAs generates functional chimeric receptors.	ADGRE5 ADGRE2	1.49e-06	2	43	2	18267122
Pubmed	Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.	MUC5B MUC5AC	1.49e-06	2	43	2	27435107
Pubmed	Mice overexpressing CD97 in intestinal epithelial cells provide a unique model for mammalian postnatal intestinal cylindrical growth.	ADGRE5 ADGRE2	1.49e-06	2	43	2	23676664
Pubmed	Mucins MUC5B and MUC5AC in Distal Airways and Honeycomb Spaces: Comparison among Idiopathic Pulmonary Fibrosis/Usual Interstitial Pneumonia, Fibrotic Nonspecific Interstitial Pneumonitis, and Control Lungs.	MUC5B MUC5AC	1.49e-06	2	43	2	26871672
Pubmed	Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution.	MUC5AC MUC6	1.49e-06	2	43	2	11988092
Pubmed	Molecular cloning and characterization of mouse CD97.	ADGRE5 ADGRE2	1.49e-06	2	43	2	10744645
Pubmed	Thrombospondin 1 requires von Willebrand factor to modulate arterial thrombosis in mice.	THBS1 VWF	1.49e-06	2	43	2	25343959
Pubmed	Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin.	MUC5B MUC5AC	1.49e-06	2	43	2	32348677
Pubmed	In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model.	MUC5B MUC5AC	1.49e-06	2	43	2	11587997
Pubmed	Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells.	ADGRE5 ADGRE2	1.49e-06	2	43	2	15498814
Pubmed	Therapeutic antibody targeting of CD97 in experimental arthritis: the role of antigen expression, shedding, and internalization on the pharmacokinetics of anti-CD97 monoclonal antibody 1B2.	ADGRE5 ADGRE2	1.49e-06	2	43	2	19717518
Pubmed	Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis.	MUC5B MUC5AC	1.49e-06	2	43	2	24332705
Pubmed	Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma.	MUC5B MUC5AC	1.49e-06	2	43	2	34656442
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	FRAS1 THBS1 LTBP2 VWF PLXDC2	2.00e-06	167	43	5	22159717
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	THBS1 LTBP2 VWF MEGF6 SSPOP	2.51e-06	175	43	5	28071719
Pubmed	Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells.	MUC5B MUC5AC	4.48e-06	3	43	2	27776277
Pubmed	Association between variations in coagulation system genes and carotid plaque.	THBS1 VWF	4.48e-06	3	43	2	22982001
Pubmed	High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells.	MUC5B MUC5AC	4.48e-06	3	43	2	29286856
Pubmed	Evaluating von Willebrand factor and ADAMTS13 levels in thalassemia major patients and assessing a possible association with Thrombospondin-1.	THBS1 VWF	4.48e-06	3	43	2	37438087
Pubmed	Mucin expression in reactive gastropathy: an immunohistochemical analysis.	MUC5AC MUC6	4.48e-06	3	43	2	17227128
Pubmed	Nebulized Menthol Impairs Mucociliary Clearance via TRPM8 and MUC5AC/MUC5B in Primary Airway Epithelial Cells.	MUC5B MUC5AC	4.48e-06	3	43	2	36675209
Pubmed	Thrombospondin-1 and ADAMTS13 competitively bind to VWF A2 and A3 domains in vitro.	THBS1 VWF	4.48e-06	3	43	2	20705333
Pubmed	Mucin phenotype expression of gastric neuroendocrine neoplasms: analysis of histopathology and carcinogenesis.	MUC5AC MUC6	4.48e-06	3	43	2	23828549
Pubmed	Th2 cytokines orchestrate the secretion of MUC5AC and MUC5B in IL-5-positive chronic rhinosinusitis with nasal polyps.	MUC5B MUC5AC	4.48e-06	3	43	2	29802623
Pubmed	Platelets Promote Metastasis via Binding Tumor CD97 Leading to Bidirectional Signaling that Coordinates Transendothelial Migration.	ADGRE5 ADGRE2	4.48e-06	3	43	2	29669286
Pubmed	P-selectin can promote thrombus propagation independently of both von Willebrand factor and thrombospondin-1 in mice.	THBS1 VWF	4.48e-06	3	43	2	27943541
Pubmed	The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity.	STAB2 VWF	4.48e-06	3	43	2	30124466
Pubmed	Cadherin-catenin adhesion system and mucin expression: a comparison between young and older patients with gastric carcinoma.	MUC5AC MUC6	4.48e-06	3	43	2	18825309
Pubmed	Structural characterization of mouse CD97 and study of its specific interaction with the murine decay-accelerating factor (DAF, CD55).	ADGRE5 ADGRE2	4.48e-06	3	43	2	10540231
Pubmed	Adenomatous and foveolar gastric dysplasia: distinct patterns of mucin expression and background intestinal metaplasia.	MUC5AC MUC6	4.48e-06	3	43	2	18300795
Pubmed	Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.	MUC5B MUC5AC	4.48e-06	3	43	2	34158522
Pubmed	A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer.	MUC5AC MUC6	4.48e-06	3	43	2	19924550
Pubmed	Deletion of either CD55 or CD97 ameliorates arthritis in mouse models.	ADGRE5 ADGRE2	4.48e-06	3	43	2	20131275
Pubmed	Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells.	MUC5B MUC5AC	4.48e-06	3	43	2	29604272
Pubmed	Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55.	ADGRE5 ADGRE2	4.48e-06	3	43	2	23447688
Pubmed	IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells.	MUC5B MUC5AC	4.48e-06	3	43	2	19596978
Pubmed	How to Obtain a Mega-Intestine with Normal Morphology: In Silico Modelling of Postnatal Intestinal Growth in a Cd97-Transgenic Mouse.	ADGRE5 ADGRE2	4.48e-06	3	43	2	34298973
Pubmed	Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex.	ADGRE5 ADGRE2	4.48e-06	3	43	2	11297558
Pubmed	Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain.	ADGRE5 ADGRE2	4.48e-06	3	43	2	33497605
Pubmed	Regulation of neuregulin 1beta1-induced MUC5AC and MUC5B expression in human airway epithelium.	MUC5B MUC5AC	4.48e-06	3	43	2	19556605
Pubmed	Aquaporin 5 expression increases mucin production in lung adenocarcinoma.	MUC5B MUC5AC	4.48e-06	3	43	2	21455588
Pubmed	Expression of leptin receptor in nasal polyps: leptin as a mucosecretagogue.	MUC5B MUC5AC	4.48e-06	3	43	2	20422702
Pubmed	Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55.	ADGRE5 ADGRE2	4.48e-06	3	43	2	17449467
Pubmed	Mucin gene polymorphisms in otitis media patients.	MUC5B MUC5AC	4.48e-06	3	43	2	19718741
Pubmed	Associations between the expression of mucins (MUC1, MUC2, MUC5AC and MUC6) and clinicopathologic parameters of human breast carcinomas.	MUC5AC MUC6	8.94e-06	4	43	2	33154304
Pubmed	ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites.	MUC5B MUC5AC	8.94e-06	4	43	2	31582416
Pubmed	Gastric mucin expression in first-degree relatives of gastric cancer patients.	MUC5AC MUC6	8.94e-06	4	43	2	24901817
Pubmed	Increased expression of MUC5AC and MUC5B promoting bacterial biofilm formation in chronic rhinosinusitis patients.	MUC5B MUC5AC	8.94e-06	4	43	2	25638393
Pubmed	Evaluation of MUC1, MUC2, MUC5AC, and MUC6 Expression Differences in Lung Adenocarcinoma Subtypes by Using a Final Immunoreactivity Score (FIRS).	MUC5AC MUC6	8.94e-06	4	43	2	36367122
Interaction	ZDHHC15 interactions	THBS1 SSPOP MUC5AC MUC6 ATRNL1 TMEFF2	1.63e-07	125	40	6	int:ZDHHC15
Interaction	SIRPD interactions	FRAS1 THBS1 MEGF8 ITGB4	2.51e-05	86	40	4	int:SIRPD
Interaction	ATN1 interactions	MEGF6 PHF20L1 MEGF8 SSPOP MEGF11	3.30e-05	187	40	5	int:ATN1
Interaction	HOXA1 interactions	SPRY2 KRTAP5-2 VWF MEGF6 MEGF8 ITGB4	6.73e-05	356	40	6	int:HOXA1
Cytoband	11p15.5	MUC5B KRTAP5-2 MUC5AC MUC6	4.74e-06	118	43	4	11p15.5
Cytoband	Ensembl 112 genes in cytogenetic band chr12q12	ADAMTS20 PLEKHA8P1	1.61e-03	63	43	2	chr12q12
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	MUC5B KRTAP5-2 MUC5AC MUC6	1.90e-03	564	43	4	chr11p15
GeneFamily	CD molecules\|Mucins	MUC5B MUC5AC MUC6	3.06e-06	21	25	3	648
GeneFamily	CD molecules\|Adhesion G protein-coupled receptors, subfamily E	ADGRE5 ADGRE2	1.83e-05	5	25	2	915
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	STAB2 SCARF2	6.31e-04	27	25	2	1253
GeneFamily	Keratin associated proteins	KRTAP29-1 KRTAP5-2	9.87e-03	109	25	2	619
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ADGRE5 ADGRE2 ITGB4	1.66e-02	394	25	3	471
Coexpression	NABA_MATRISOME	ADAMTS20 FRAS1 THBS1 MUC5B LTBP2 VWF FLG2 MEGF6 MEGF8 PLXDC2 SSPOP MUC5AC MUC6 MEGF11 SVEP1 PDGFD	2.03e-12	1008	43	16	MM17056
Coexpression	NABA_MATRISOME	ADAMTS20 FRAS1 THBS1 MUC5B LTBP2 VWF FLG2 MEGF6 MEGF8 PLXDC2 SSPOP MUC5AC MUC6 MEGF11 SVEP1 PDGFD	2.66e-12	1026	43	16	M5889
Coexpression	NABA_MATRISOME_ASSOCIATED	ADAMTS20 MUC5B FLG2 MEGF6 MEGF8 PLXDC2 MUC5AC MUC6 MEGF11 PDGFD	2.44e-07	738	43	10	MM17058
Coexpression	NABA_MATRISOME_ASSOCIATED	ADAMTS20 MUC5B FLG2 MEGF6 MEGF8 PLXDC2 MUC5AC MUC6 MEGF11 PDGFD	2.86e-07	751	43	10	M5885
Coexpression	NABA_ECM_GLYCOPROTEINS	FRAS1 THBS1 LTBP2 VWF SSPOP SVEP1	6.74e-07	191	43	6	MM17059
Coexpression	NABA_ECM_GLYCOPROTEINS	FRAS1 THBS1 LTBP2 VWF SSPOP SVEP1	7.84e-07	196	43	6	M3008
Coexpression	NABA_CORE_MATRISOME	FRAS1 THBS1 LTBP2 VWF SSPOP SVEP1	5.00e-06	270	43	6	MM17057
Coexpression	NABA_CORE_MATRISOME	FRAS1 THBS1 LTBP2 VWF SSPOP SVEP1	5.56e-06	275	43	6	M5884
Coexpression	SIMBULAN_UV_RESPONSE_NORMAL_DN	THBS1 FAT2 ITGB4	2.17e-05	33	43	3	M16114
Coexpression	GSE37532_VISCERAL_ADIPOSE_TISSUE_VS_LN_DERIVED_TCONV_CD4_TCELL_DN	KRTAP5-2 STAB2 MEGF8 MEGF11	3.19e-05	110	43	4	M8946
Coexpression	NABA_MATRISOME_PRIMARY_METASTATIC_COLORECTAL_TUMOR	LTBP2 MEGF8 SVEP1	1.25e-04	59	43	3	M47989
Coexpression	NABA_ECM_AFFILIATED	MUC5B PLXDC2 MUC5AC MUC6	1.31e-04	158	43	4	MM17063
Coexpression	NABA_ECM_AFFILIATED	MUC5B PLXDC2 MUC5AC MUC6	1.73e-04	170	43	4	M5880
Coexpression	DESCARTES_ORGANOGENESIS_EPITHELIAL_CELLS	TERB1 FRAS1 FAT2 ITGB4	1.93e-04	175	43	4	MM3643
Coexpression	NABA_SECRETED_FACTORS	FLG2 MEGF6 MEGF8 MEGF11 PDGFD	2.23e-04	338	43	5	MM17064
Coexpression	NABA_SECRETED_FACTORS	FLG2 MEGF6 MEGF8 MEGF11 PDGFD	2.39e-04	343	43	5	M5883
Coexpression	CUI_DEVELOPING_HEART_VASCULAR_ENDOTHELIAL_CELL	GATA2 LTBP2 MEGF6 PDGFD	2.81e-04	193	43	4	M39321
Coexpression	GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_DN	STAB2 SLCO1B1 SSPOP MEGF11	2.86e-04	194	43	4	M8285
Coexpression	DESCARTES_FETAL_STOMACH_GOBLET_CELLS	MUC5AC MUC6	3.11e-04	16	43	2	M40303
Coexpression	MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED	TERB1 ADGRE5 ADGRE2 SCARF2 ITGB4 PDGFD	3.29e-04	574	43	6	MM820
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS20 FRAS1 MUC5B STAB2 ZAN SSPOP LRP1B	4.85e-10	184	43	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS20 FRAS1 MUC5B STAB2 ZAN SSPOP LRP1B	4.85e-10	184	43	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS20 FRAS1 MUC5B STAB2 ZAN SSPOP LRP1B	4.85e-10	184	43	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FRAS1 STAB2 ZAN SLCO1B1 MUC6 LINC00575	3.08e-08	193	43	6	315840bc48899f3a36d57b19197509de19716e3d
ToppCell	Nasal_Brush-Epithelial-Ionocytes\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	THBS1 LTBP2 VWF PLXDC2 SERINC4	6.59e-07	172	43	5	04fabb40fa9357d8902f3b04adc15231626cd9f8
ToppCell	Nasal_Brush-Epithelial-Ionocytes\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	THBS1 LTBP2 VWF PLXDC2 SERINC4	6.59e-07	172	43	5	dd3a23dc78dc6939f41126f8d7bd23a2e4713647
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRY2 THBS1 PLXDC2 SCARF2 SVEP1	7.38e-07	176	43	5	fee4e0f32aaf77294040c7af6c1f503571750d43
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRY2 THBS1 PLXDC2 SCARF2 SVEP1	7.38e-07	176	43	5	f25251abd4ef9fb077a978f9f9f658af58e4e0d2
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GATA2 VWF MEGF6 ITGB4 TMEFF2	1.05e-06	189	43	5	d17e8467699c7ca7694a313c26111f085df5204e
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 ADGRE2 PLXDC2 SVEP1 PDGFD	1.05e-06	189	43	5	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	LTBP2 VWF PLXDC2 SVEP1 PDGFD	1.13e-06	192	43	5	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 ADGRE2 PLXDC2 SVEP1 PDGFD	1.13e-06	192	43	5	ee085e04d5dcfb657522484ed20b8c1ddeccfe0c
ToppCell	droplet-Heart-HEART-1m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GATA2 VWF MEGF6 ITGB4 MEGF11	1.16e-06	193	43	5	d0a5f212f8e8a13dbbe3e41df92548ef82eef70b
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-3\|TCGA-Stomach / Sample_Type by Project: Shred V9	THBS1 LTBP2 PLXDC2 SCARF2 SVEP1	1.19e-06	194	43	5	2260cd817a6661e5eb6645b0c6786e18fd58371e
ToppCell	COVID-19-Heart-Fib_2\|Heart / Disease (COVID-19 only), tissue and cell type	THBS1 LTBP2 PLXDC2 SVEP1 PDGFD	1.19e-06	194	43	5	d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCell	Bronchial_Brush-Epithelial-Basal_1\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	SPRY2 FRAS1 LTBP2 MEGF6 PLXDC2	1.29e-06	197	43	5	f5d87824c0020c95d89e069fd9f70b49e5d5fcea
ToppCell	Bronchial_Brush-Epithelial-Basal_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SPRY2 FRAS1 LTBP2 MEGF6 PLXDC2	1.32e-06	198	43	5	10a17d7c116dcd6cf847fe6f5d7196d887cad1f9
ToppCell	COVID-19-lung-Fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	FRAS1 THBS1 LTBP2 PLXDC2 SVEP1	1.32e-06	198	43	5	df3de77216f5c5d6141ec44d01c56b942f611838
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 THBS1 LTBP2 PLXDC2 SVEP1	1.39e-06	200	43	5	e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	THBS1 ADGRE2 PLXDC2 SVEP1 PDGFD	1.39e-06	200	43	5	a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 THBS1 LTBP2 PLXDC2 SVEP1	1.39e-06	200	43	5	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-T_lymphocytic-double-positive,_alpha-beta_thymocyte\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MUC5B MUC5AC MEGF11 SERINC4	5.66e-06	121	43	4	25fa58d8e07dab572b2ba8e23c9d1ad3502dfc56
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FAT2 LTBP2 ADGRE2 SVEP1	1.32e-05	150	43	4	7a9d6a7ff8000e9a061e1b586e4c258cc91a2a09
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FAT2 LTBP2 ADGRE2 SVEP1	1.32e-05	150	43	4	e5b843cb2bc847f6cab4cbec0a2a6a72fac50fee
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 MUC5B LRP1B SVEP1	1.71e-05	160	43	4	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 MUC5B LRP1B SVEP1	1.71e-05	160	43	4	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	primary_visual_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Ctla2a\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GATA2 ADGRE5 VWF PDGFD	1.75e-05	161	43	4	a60ef3f390f56bb05b687b17986fe6382f69f260
ToppCell	primary_visual_cortex-Non-neuronal-endothelial_cell-Endo\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GATA2 ADGRE5 VWF PDGFD	1.79e-05	162	43	4	0bdb1e5ba33e162bec1acb28256c1405a7658ee5
ToppCell	primary_visual_cortex-Non-neuronal-endothelial_cell\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GATA2 ADGRE5 VWF PDGFD	1.79e-05	162	43	4	5799a602ef8d83925907e8e34532428be7330228
ToppCell	frontal_cortex-Non-neuronal-endothelial_cell\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GATA2 ADGRE5 VWF PDGFD	1.88e-05	164	43	4	6a41a159134e605b80d5e731f9ed5bc803bb531b
ToppCell	frontal_cortex-Non-neuronal-endothelial_cell-Endo\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GATA2 ADGRE5 VWF PDGFD	1.88e-05	164	43	4	ec68954fc09b6850273b5e59caa6b09d02151097
ToppCell	frontal_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Ctla2a\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GATA2 ADGRE5 VWF PDGFD	1.97e-05	166	43	4	27af6c906cff1d40d134f0386db7708869691121
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STAB2 VWF MEGF6 ITGB4	2.02e-05	167	43	4	f01b96173deda0239fa482989873cf308e49d48c
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STAB2 VWF MEGF6 ITGB4	2.02e-05	167	43	4	5fc85a05124cd2324e1b8ff940193880f83cd8af
ToppCell	facs-Heart-LV-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRY2 THBS1 PLXDC2 SCARF2	2.11e-05	169	43	4	849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 LTBP2 ZAN LRP1B	2.11e-05	169	43	4	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	Control-Mast_cells-Mast_cells\|Control / group, cell type (main and fine annotations)	GATA2 ADGRE2 LRP1B TMEFF2	2.16e-05	170	43	4	c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GATA2 VWF MEGF6 ITGB4	2.16e-05	170	43	4	af8b56555cbd5a1016ab9ec2ce88225c58c89648
ToppCell	AT1-AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	MUC5B MUC5AC ITGB4 MUC6	2.27e-05	172	43	4	0be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCell	E15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GATA2 VWF ITGB4 PDGFD	2.32e-05	173	43	4	b0ff9808e38cb64a734ced498cd0546728746cd5
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF MEGF6 ITGB4 TMEFF2	2.42e-05	175	43	4	2e54961846c65b185d9bd6e305dd81205579d890
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF MEGF6 ITGB4 TMEFF2	2.42e-05	175	43	4	efa6a05f7417d46141b6e635f258c126b7a03aa1
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GATA2 VWF ADGRE2 PDGFD	2.48e-05	176	43	4	77516048aefbe1f48e825052756df0c310c1c486
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GATA2 VWF ADGRE2 PDGFD	2.48e-05	176	43	4	96779273b94345250cf53ba671203345b43d9e00
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GATA2 VWF ITGB4 PDGFD	2.48e-05	176	43	4	27e6b3ae41068d6cfdda3d46da7df2a27567140e
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GATA2 VWF ITGB4 PDGFD	2.48e-05	176	43	4	d6a5470af9592f34a741265f2ea9651c05c3add3
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GATA2 VWF MEGF6 PDGFD	2.77e-05	181	43	4	2c44c41b4e8a75ebdbaeb0c6cc5a03f17c44758c
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DISP2 VWF MEGF6 ITGB4	2.77e-05	181	43	4	cef034030e6b029a49ae56be37ea1fac1a5c350e
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GATA2 VWF ZAN ITGB4	2.83e-05	182	43	4	d0e3663f7d39f22a3ebd7fde56ab3504773598f4
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LTBP2 VWF SVEP1 PDGFD	2.83e-05	182	43	4	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GATA2 THBS1 STAB2 VWF	2.95e-05	184	43	4	3b0389c3a5a16697de860e98ebc48ed39ede646f
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GATA2 SPRY2 PLXDC2 MUC6	3.01e-05	185	43	4	5527fa9d2e0b2f3607602e18ba94de4e9bbc6824
ToppCell	Control-Epithelial-Basal\|Epithelial / Disease state, Lineage and Cell class	FAT2 LTBP2 PLXDC2 ITGB4	3.01e-05	185	43	4	d5d6d13e2f20b54ca55645b9a757b8599f4fd897
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ADAMTS20 THBS1 PLXDC2 LRP1B	3.08e-05	186	43	4	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GATA2 VWF ITGB4 PDGFD	3.08e-05	186	43	4	5302399825f213d105ac70b91366a4513b732838
ToppCell	COVID-19-kidney-Fibroblast-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	THBS1 ADGRE2 ATRNL1 SVEP1	3.14e-05	187	43	4	76bfe8c42430a230a8bdf299575c444fb7780f24
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	FRAS1 LTBP2 PLXDC2 SVEP1	3.14e-05	187	43	4	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	GATA2 VWF PLXDC2 ITGB4	3.14e-05	187	43	4	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	THBS1 LTBP2 SCARF2 SVEP1	3.14e-05	187	43	4	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	Endothelial-Endothelial-E\|Endothelial / shred on cell class and cell subclass (v4)	VWF MEGF6 PLXDC2 ITGB4	3.21e-05	188	43	4	2777eb7689b271c199021fe7d9db88ccebff14de
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 PLXDC2 SVEP1 PDGFD	3.27e-05	189	43	4	e9d5e858e320c6e9913c1ea6a54967d21eda605f
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GATA2 VWF MEGF6 PDGFD	3.27e-05	189	43	4	feedac2751ed770f80bc56fec31662b5b3826f58
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	MUC5B FAT2 MUC5AC ITGB4	3.27e-05	189	43	4	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GATA2 VWF ADGRE2 MEGF6	3.27e-05	189	43	4	1e1afa66b32ae752c0a42b02b80f10205464569c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRE5 THBS1 ATRNL1 SVEP1	3.34e-05	190	43	4	1121eb607a984c59fbffe7220837fc178745aa55
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRE5 THBS1 ATRNL1 SVEP1	3.34e-05	190	43	4	048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 PLXDC2 SVEP1 PDGFD	3.34e-05	190	43	4	45df8fee00f8949937863159d7aa042e72748d9b
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF MEGF6 ITGB4 PDGFD	3.34e-05	190	43	4	d87b9e9ca863270a9c7f61674271a6440c97d1f4
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	THBS1 LTBP2 PLXDC2 SVEP1	3.34e-05	190	43	4	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 PLXDC2 SVEP1 PDGFD	3.34e-05	190	43	4	d60395739458d7f47a3350ade751fe3819500320
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 PLXDC2 SVEP1 PDGFD	3.41e-05	191	43	4	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	droplet-Pancreas-PANCREAS-30m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GATA2 THBS1 VWF MEGF6	3.41e-05	191	43	4	471205494b91be69926dc8159376132bcea0d9b5
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 ADGRE2 ATRNL1 SVEP1	3.41e-05	191	43	4	1caf726bd07fdca389e678fc16304a6ef1790423
ToppCell	droplet-Lung-LUNG-1m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TERB1 VWF MEGF6 ITGB4	3.41e-05	191	43	4	9fc674a58f20b47255e4457d5195c8cff17b0414
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THBS1 PLXDC2 SCARF2 SVEP1	3.41e-05	191	43	4	80484d39f34703a33b9bac09826b7a526e883cab
ToppCell	P03-Endothelial-large_vessel_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GATA2 VWF MEGF6 ITGB4	3.41e-05	191	43	4	b680e0c35f1004be36f9f0680ae3c62952e2b607
ToppCell	facs-Aorta-Heart-18m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRY2 PLXDC2 SVEP1 TMEFF2	3.41e-05	191	43	4	6242f83acaf1714e9c1771a832cb67674b19e96d
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FRAS1 LRP1B PDGFD TMEFF2	3.41e-05	191	43	4	156b467187331ac6ca390d6ca861d9670bb7b956
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THBS1 PLXDC2 SCARF2 SVEP1	3.41e-05	191	43	4	5c4e4e9de14edfae072a2a2882220a31bebf51b2
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GATA2 VWF MEGF6 ITGB4	3.41e-05	191	43	4	b270c3dd5952f56b9bdceabe13e298fe6757563b
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GATA2 VWF MEGF6 ITGB4	3.41e-05	191	43	4	27f23c2254b610abac1a88d0fecff305addde9da
ToppCell	LV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	LTBP2 PLXDC2 SVEP1 PDGFD	3.41e-05	191	43	4	d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCell	droplet-Lung-LUNG-1m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TERB1 VWF MEGF6 ITGB4	3.41e-05	191	43	4	c379a499dabf3c9ed80f47adbb2d949821c5b053
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRY2 THBS1 PLXDC2 TMEFF2	3.41e-05	191	43	4	1b26056df078674f37a6c06f6256b30cfcec21a7
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 ADGRE2 ATRNL1 SVEP1	3.41e-05	191	43	4	3d60c46bced2984c27a1fcf2910bc38b31fb0148
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 ADGRE2 ATRNL1 SVEP1	3.48e-05	192	43	4	4022f208eb5db760abd0aac782a25e8ab63efc64
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GATA2 THBS1 VWF SLCO1B1	3.48e-05	192	43	4	eafead22bba48ac5ee568faa8946c444445c1034
ToppCell	droplet-Kidney-nan-18m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LTBP2 SCARF2 SVEP1 TMEFF2	3.48e-05	192	43	4	38d7a24ae205ef91ed2e0f402d8022f2a9cdb243
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 PLXDC2 SVEP1 PDGFD	3.48e-05	192	43	4	6f4ef24dab544681304b7f8a9dc073e7edaa4cf5
ToppCell	droplet-Lung-1m-Endothelial-venous_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TERB1 VWF MEGF6 ITGB4	3.48e-05	192	43	4	1990dc8a81594018a5bf596be99d0b5f0af0f58f
ToppCell	facs-Aorta-Heart-18m-Mesenchymal\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRY2 PLXDC2 SVEP1 TMEFF2	3.48e-05	192	43	4	6d4fe7ea278efa4b9d43f8a3c282bc0e0e9abaea
ToppCell	facs-BAT-Fat-24m-Mesenchymal-mesenchymal_progenitor\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRY2 PLXDC2 SVEP1 TMEFF2	3.48e-05	192	43	4	0b3161ce3add9f7457f4cfa5749dbb6501e3ad36
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF MEGF6 ITGB4 PDGFD	3.48e-05	192	43	4	285a9d332a1e07b94f222d4b518dd56928b9e075
ToppCell	droplet-Lung-nan-18m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GATA2 VWF MEGF6 ITGB4	3.48e-05	192	43	4	45929c757d873fe314cc36d27abd265414635490
ToppCell	facs-BAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRY2 PLXDC2 SVEP1 TMEFF2	3.48e-05	192	43	4	61c7ec6171c519b2f3e9ce623669162c0c6ba9f5
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LTBP2 SCARF2 SVEP1 TMEFF2	3.48e-05	192	43	4	04d155897ed075c359933080e36a4ab2150b6e9f
ToppCell	facs-Aorta-Heart-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRY2 PLXDC2 SVEP1 TMEFF2	3.48e-05	192	43	4	2c6406bc97c3224099b94a43f2890f057b528fa6
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 PLXDC2 SVEP1 PDGFD	3.48e-05	192	43	4	f4fc2b0121f879bab2bee99dfb5ff2c3ca1c0e1b
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 ADGRE2 SVEP1 PDGFD	3.48e-05	192	43	4	df1545670370fb1010c567cd059c2783eab315f7
ToppCell	LPS_only-Stromal_mesenchymal\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 PLXDC2 SVEP1 PDGFD	3.48e-05	192	43	4	162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
Drug	DB08569	VWF PROZ ITGB4	1.27e-06	12	42	3	CID016122642
Drug	1,2,5,6-dibenzanthracene	GATA2 DISP2 THBS1 LTBP2 STAB2 VWF MEGF6 ITGB4 PDGFD TMEFF2	2.16e-06	837	42	10	ctd:C026486
Drug	Fenoterol hydrobromide [1944-12-3]; Up 200; 10.4uM; PC3; HT_HG-U133A	GATA2 THBS1 MUC5B PROZ MUC5AC	2.07e-05	182	42	5	6331_UP
Drug	Novobiocin sodium salt [1476-53-5]; Up 200; 6.4uM; PC3; HT_HG-U133A	THBS1 MEGF6 SLCO1B1 MUC5AC SVEP1	2.74e-05	193	42	5	4569_UP
Drug	11-deoxy-16,16-dimethyl Prostaglandin E2; Down 200; 10uM; MCF7; HT_HG-U133A	FRAS1 LTBP2 STAB2 MEGF6 MEGF8	3.02e-05	197	42	5	7533_DN
Drug	Vancomycin hydrochloride [1404-93-9]; Up 200; 2.6uM; PC3; HT_HG-U133A	ADGRE2 MEGF6 SLCO1B1 SVEP1 KLHL22	3.02e-05	197	42	5	4598_UP
Drug	Fenspiride hydrochloride [5053-08-7]; Down 200; 13.4uM; MCF7; HT_HG-U133A	SPRY2 ADGRE5 LTBP2 STAB2 KLHL22	3.02e-05	197	42	5	2269_DN
Drug	Paromomycin sulfate [1263-89-4]; Up 200; 5.6uM; MCF7; HT_HG-U133A	ADGRE5 PROZ MUC5AC SVEP1 KLHL22	3.10e-05	198	42	5	3356_UP
Drug	Florfenicol [73231-34-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A	SPRY2 LTBP2 SLCO1B1 ITGB4 MUC6	3.10e-05	198	42	5	6460_UP
Disease	cholangiocarcinoma (is_marker_for)	THBS1 MUC5B MUC5AC MUC6	2.12e-06	64	42	4	DOID:4947 (is_marker_for)
Disease	adhesion G protein-coupled receptor E2 measurement	ADGRE5 ADGRE2	1.18e-05	4	42	2	EFO_0021892
Disease	pancreatic cancer (is_marker_for)	ADGRE5 THBS1 MUC5AC MUC6	1.31e-05	101	42	4	DOID:1793 (is_marker_for)
Disease	mucinous adenocarcinoma (is_marker_for)	MUC5AC MUC6	1.97e-05	5	42	2	DOID:3030 (is_marker_for)
Disease	severe acute respiratory syndrome, COVID-19	LTBP2 MEGF6 PLXDC2 LRP1B SCARF2 MEGF11	3.86e-05	447	42	6	EFO_0000694, MONDO_0100096
Disease	mesangial proliferative glomerulonephritis (biomarker_via_orthology)	VWF PDGFD	5.51e-05	8	42	2	DOID:4783 (biomarker_via_orthology)
Disease	adverse effect, response to xenobiotic stimulus	STAB2 LRP1B TMEFF2	8.25e-05	59	42	3	EFO_0009658, GO_0009410
Disease	pancreatic ductal carcinoma (is_marker_for)	THBS1 MUC5B MUC5AC	9.11e-05	61	42	3	DOID:3587 (is_marker_for)
Disease	pulmonary fibrosis	MUC5B MUC5AC	1.08e-04	11	42	2	EFO_0009448
Disease	gastric ulcer (implicated_via_orthology)	MUC5AC MUC6	1.78e-04	14	42	2	DOID:10808 (implicated_via_orthology)
Disease	FEV/FEC ratio	SPRY2 FRAS1 LTBP2 MEGF6 PLXDC2 SLCO1B1 USP3 SCARF2	2.94e-04	1228	42	8	EFO_0004713
Disease	cortical surface area measurement, neuroimaging measurement	ADAMTS20 THBS1 MEGF6 PDGFD	3.04e-04	227	42	4	EFO_0004346, EFO_0010736
Disease	factor VIII measurement, Ischemic stroke	STAB2 VWF	3.33e-04	19	42	2	EFO_0004630, HP_0002140
Disease	cortical surface area measurement	ADAMTS20 SPRY2 THBS1 ZAN MEGF6 PLXDC2 SVEP1 PDGFD	5.39e-04	1345	42	8	EFO_0010736
Disease	factor VIII measurement, von Willebrand factor measurement	STAB2 VWF	6.79e-04	27	42	2	EFO_0004629, EFO_0004630
Disease	acylcarnitine measurement	SLCO1B1 USP3 PDGFD	7.91e-04	127	42	3	EFO_0005059
Disease	Ischemic stroke, von Willebrand factor measurement	STAB2 VWF	8.39e-04	30	42	2	EFO_0004629, HP_0002140
Disease	factor VIII measurement, venous thromboembolism	STAB2 VWF	1.08e-03	34	42	2	EFO_0004286, EFO_0004630
Disease	retinal detachment, retinal break	FRAS1 PLXDC2	1.14e-03	35	42	2	EFO_0005773, EFO_0010698
Disease	COVID-19 symptoms measurement	MUC5B MUC5AC	1.14e-03	35	42	2	EFO_0600019
Disease	Behcet's disease (is_implicated_in)	VWF PROZ	1.21e-03	36	42	2	DOID:13241 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SRGCARWCPQDSSCV	ADGRE2	26	Q9UHX3
CARWCPQNSSCVNAT	ADGRE5	26	P48960
SPHCGCCQAWSISSF	LINC01600	76	Q96MT4
CQRTAANQCCPSWSL	DISP2	326	A7MBM2
NQWRTGPWGSCSSSC	ADAMTS20	1306	P59510
NTTCSSCTCSGGLWQ	MUC5B	401	Q9HC84
WACQQGTHCPSTCTL	MUC6	856	Q6W4X9
CGGQWRTGSSQSSCC	FLG2	366	Q5D862
PSGTWGLNCNESCTC	MEGF11	481	A6BM72
TEWASSPCSVCSCNH	FRAS1	106	Q86XX4
CDSSCSWNQFACSAQ	LRP1B	2716	Q9NZR2
CGCGTVNWRSCTCNS	PDGFD	306	Q9GZP0
CSQNTCLNGGKCSWT	FAT2	3951	Q9NYQ8
SSPEACNQSGACTWC	MEGF8	1881	Q7Z7M0
TDCTNCTCSGGRWSC	MUC5AC	411	P98088
CSEGWSGQTCNCSTG	ITGB4	481	P16144
GTCCANCQTTTTTLW	GATA2	346	P23769
CYSCTSGQWSSVCPL	KLHL22	516	Q53GT1
SHPSCCCTVSNSSWN	CERK	486	Q8TCT0
ADCASCTANTNGCQW	ATRNL1	671	Q5VV63
TTQAECCCTQGASWG	LTBP2	1431	Q14767
VCSWVPACSCTSCGS	KRTAP5-2	66	Q701N4
CTASPCQPTWCQGSS	KRTAP29-1	176	A8MX34
CQPTWCQGSSCQPVS	KRTAP29-1	181	A8MX34
GACLCSSCAWTSDSR	LINC00575	11	Q6W349
SWCCPIDPAGSCNQS	PHF20L1	151	A8MW92
WYGPSCQTRCSCAND	MEGF6	821	O75095
SCAPGWTGFSCQRAC	MEGF6	846	O75095
FPNGCSSLCWSSCGQ	RTTN	1981	Q86VV8
SQSGSDSSCSPECLW	PLEKHA8P1	171	O95397
SCVSGLIANCSSWPC	SSPOP	3166	A2VEC9
TPWSQCSASCGPARC	SSPOP	3191	A2VEC9
SPRQCSSWTLCEGFC	TMEFF2	6	Q9UIK5
PCVSSQIGFNCSWCS	PLXDC2	336	Q6UX71
SCQDSIWGYTCTCSP	PROZ	101	P22891
WTGSRCHTAVCQSPC	SVEP1	3526	Q4LDE5
KWSTNNCGTRGSCRT	SLCO1B1	601	Q9Y6L6
PCSCSQSHCCTRWSA	SPRY2	241	O43597
SEWTSCSTSCGNGIQ	THBS1	386	P07996
GCRWTCPCVCTGSST	VWF	1941	P04275
WWGRSCNNQCACNSS	SCARF2	206	Q96GP6
CCHSRWPSLTASTCS	SERINC4	46	A6NH21
ECGSCVNTPSCPRWS	STAB2	1901	Q8WWQ8
NGSPSSWCCSVCRSN	USP3	21	Q9Y6I4
WSSVCSTLCVCVNNP	TERB1	176	Q8NA31
SYTNCLPSCSPSCWD	ZAN	2216	Q9Y493