Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	membrane lipid biosynthetic process	PRKD3 PIGL PRKD1 GAL3ST2 ACER1	1.27e-05	157	40	5	GO:0046467
GeneOntologyBiologicalProcess	membrane lipid metabolic process	PRKD3 PIGL PRKD1 GAL3ST2 ACER1	7.74e-05	229	40	5	GO:0006643
Domain	Protein_Kinase_C_mu-related	PRKD3 PRKD1	1.41e-05	3	41	2	IPR015727
Domain	SSD	PTCH2 DISP2	3.61e-04	13	41	2	PS50156
Domain	SSD	PTCH2 DISP2	3.61e-04	13	41	2	IPR000731
Domain	IQ	ASPM MYO1B UBE3C	5.06e-04	71	41	3	PF00612
Domain	IQ	ASPM MYO1B UBE3C	7.44e-04	81	41	3	SM00015
Domain	DAG/PE-bd	PRKD3 PRKD1	9.62e-04	21	41	2	IPR020454
Domain	IQ_motif_EF-hand-BS	ASPM MYO1B UBE3C	1.01e-03	90	41	3	IPR000048
Domain	IQ	ASPM MYO1B UBE3C	1.11e-03	93	41	3	PS50096
Domain	HECT	UBE3C WWP1	1.59e-03	27	41	2	PF00632
Domain	HECTc	UBE3C WWP1	1.59e-03	27	41	2	SM00119
Domain	HECT_dom	UBE3C WWP1	1.59e-03	27	41	2	IPR000569
Domain	HECT	UBE3C WWP1	1.59e-03	27	41	2	PS50237
Domain	C1_1	PRKD3 PRKD1	6.95e-03	57	41	2	PF00130
Domain	ZF_DAG_PE_1	PRKD3 PRKD1	8.70e-03	64	41	2	PS00479
Domain	ZF_DAG_PE_2	PRKD3 PRKD1	8.70e-03	64	41	2	PS50081
Domain	C1	PRKD3 PRKD1	8.96e-03	65	41	2	SM00109
Domain	CH	ASPM EHBP1L1	8.96e-03	65	41	2	SM00033
Domain	PE/DAG-bd	PRKD3 PRKD1	9.23e-03	66	41	2	IPR002219
Domain	CH	ASPM EHBP1L1	1.03e-02	70	41	2	PF00307
Pubmed	A role for PKD1 and PKD3 activation in modulation of calcium oscillations induced by orexin receptor 1 stimulation.	PRKD3 PRKD1 HCRTR1	1.52e-09	3	41	3	20621130
Pubmed	Protein kinase D interacts with neuronal nitric oxide synthase and phosphorylates the activatory residue serine 1412.	PRKD1 NOS1	1.36e-06	2	41	2	24740233
Pubmed	Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer.	PRKD3 PRKD1	4.06e-06	3	41	2	26253275
Pubmed	Expression of the protein kinase D (PKD) family during mouse embryogenesis.	PRKD3 PRKD1	4.06e-06	3	41	2	16377259
Pubmed	A Novel Conserved Domain Mediates Dimerization of Protein Kinase D (PKD) Isoforms: DIMERIZATION IS ESSENTIAL FOR PKD-DEPENDENT REGULATION OF SECRETION AND INNATE IMMUNITY.	PRKD3 PRKD1	4.06e-06	3	41	2	27662904
Pubmed	Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells.	PRKD3 PRKD1	4.06e-06	3	41	2	32747433
Pubmed	Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland.	PRKD3 PRKD1	4.06e-06	3	41	2	26426580
Pubmed	Effect of deletion of the protein kinase PRKD1 on development of the mouse embryonic heart.	PRKD3 PRKD1	4.06e-06	3	41	2	38419169
Pubmed	Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1.	DBH NOS1 LHX9	4.36e-06	27	41	3	20080794
Pubmed	Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network.	PRKD3 PRKD1	8.12e-06	4	41	2	14743217
Pubmed	Excitation of Cortical nNOS/NK1R Neurons by Hypocretin 1 is Independent of Sleep Homeostasis.	NOS1 HCRTR1	1.35e-05	5	41	2	29462275
Pubmed	Protein kinase D regulates RhoA activity via rhotekin phosphorylation.	PRKD3 PRKD1	1.35e-05	5	41	2	22228765
Pubmed	Characterization of G protein-coupled receptor 56 protein expression in the mouse developing neocortex.	EOMES ADGRG1	2.03e-05	6	41	2	22351047
Pubmed	Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality.	DBH NOS1	2.84e-05	7	41	2	34585668
Pubmed	ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.	EOMES ASPM	3.78e-05	8	41	2	27562601
Pubmed	Projections and interconnections of genetically defined serotonin neurons in mice.	EOMES ADGRG1	4.86e-05	9	41	2	22151329
Pubmed	Lmx1a regulates fates and location of cells originating from the cerebellar rhombic lip and telencephalic cortical hem.	EOMES LHX9	4.86e-05	9	41	2	20498066
Pubmed	Dependence of serotonergic and other nonadrenergic enteric neurons on norepinephrine transporter expression.	DBH NOS1	6.07e-05	10	41	2	21148012
Pubmed	Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C.	PRKD3 PRKD1	7.41e-05	11	41	2	2182321
Pubmed	In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46.	PRKD3 PRKD1	7.41e-05	11	41	2	8914829
Pubmed	The transcription factor NF-YA is crucial for neural progenitor maintenance during brain development.	EOMES ASPM	7.41e-05	11	41	2	38199563
Pubmed	TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43.	PRKD1 UBE3C	8.88e-05	12	41	2	38367882
Pubmed	Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.	EOMES ASPM	8.88e-05	12	41	2	20823249
Pubmed	HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta.	PRKD3 PRKD1	8.88e-05	12	41	2	11919157
Pubmed	The zinc finger gene Fezf2 is required for the development of excitatory neurons in the basolateral complex of the amygdala.	NOS1 LHX9	1.05e-04	13	41	2	24723342
Pubmed	CbGRiTS: cerebellar gene regulation in time and space.	EOMES LHX9	1.05e-04	13	41	2	25446528
Pubmed	Loss of Aspm causes increased apoptosis of developing neural cells during mouse cerebral corticogenesis.	EOMES ASPM	1.05e-04	13	41	2	38019816
Pubmed	Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans.	NOS1 LHX9	1.22e-04	14	41	2	12379852
Pubmed	Basal progenitor cells in the embryonic mouse thalamus - their molecular characterization and the role of neurogenins and Pax6.	EOMES LHX9	1.22e-04	14	41	2	22077982
Pubmed	Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.	EOMES ASPM	1.22e-04	14	41	2	27974163
Pubmed	Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons.	DBH NOS1	1.22e-04	14	41	2	12810600
Pubmed	Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes.	PRKD3 PRKD1	1.41e-04	15	41	2	8627654
Pubmed	Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.	UBE3C WWP1	1.61e-04	16	41	2	25723849
Pubmed	Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins.	ASPM SFI1	1.61e-04	16	41	2	29764992
Pubmed	Differential expression of the Tmem132 family genes in the developing mouse nervous system.	EOMES TMEM132B	1.61e-04	16	41	2	35690356
Pubmed	[HIV-1 Tat protein induces IL-10 production by human monocytes: implications of the PKC and calcium pathway].	PRKD3 PRKD1	1.61e-04	16	41	2	11833470
Pubmed	Contribution of Hox genes to the diversity of the hindbrain sensory system.	DBH LHX9	1.82e-04	17	41	2	14960494
Pubmed	Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala.	NOS1 LHX9	1.82e-04	17	41	2	20507551
Pubmed	Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly.	EOMES ASPM	2.05e-04	18	41	2	28272472
Pubmed	The p75 neurotrophin receptor is required for the survival of neuronal progenitors and normal formation of the basal forebrain, striatum, thalamus and neocortex.	EOMES LHX9	2.05e-04	18	41	2	31488566
Pubmed	Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of glia.	DBH NOS1	2.29e-04	19	41	2	17507395
Pubmed	Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway.	PRKD3 PRKD1	2.54e-04	20	41	2	11044099
Pubmed	The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala.	EOMES NOS1	2.54e-04	20	41	2	29869132
Pubmed	Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias.	EOMES ASPM	2.54e-04	20	41	2	34237032
Pubmed	The transcription factor Foxg1 regulates the competence of telencephalic cells to adopt subpallial fates in mice.	EOMES LHX9	2.81e-04	21	41	2	20081193
Pubmed	Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon.	EOMES LHX9	2.81e-04	21	41	2	17158062
Pubmed	Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.	PRKD3 PRKD1	2.81e-04	21	41	2	9446795
Pubmed	Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways.	PRKD3 PRKD1	2.81e-04	21	41	2	9671211
Pubmed	Zbtb20 Regulates Developmental Neurogenesis in the Olfactory Bulb and Gliogenesis After Adult Brain Injury.	EOMES NOS1	3.09e-04	22	41	2	29748916
Pubmed	HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.	PRKD3 PRKD1	3.09e-04	22	41	2	11154208
Pubmed	Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2.	EOMES UBE3C	3.09e-04	22	41	2	18460603
Pubmed	FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation.	EOMES LHX9	3.38e-04	23	41	2	19668217
Pubmed	Genome-wide microarray comparison reveals downstream genes of Pax6 in the developing mouse cerebellum.	EOMES LHX9	3.38e-04	23	41	2	22817342
Pubmed	Foxg1 confines Cajal-Retzius neuronogenesis and hippocampal morphogenesis to the dorsomedial pallium.	EOMES LHX9	3.68e-04	24	41	2	15858069
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	PRKD3 PRKD1	3.68e-04	24	41	2	10843712
Pubmed	Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion.	EOMES ASPM	4.00e-04	25	41	2	39271675
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	UBE3C WWP1	4.33e-04	26	41	2	26949039
Pubmed	Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.	ASPM ADAM15	5.78e-04	30	41	2	19054571
Pubmed	Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing.	DBH NOS1	6.58e-04	32	41	2	33288908
Pubmed	Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.	EOMES ELMO2	8.80e-04	37	41	2	27565344
Pubmed	Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.	PRKD3 PRKD1	9.28e-04	38	41	2	12482669
Pubmed	WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis.	EOMES ASPM	9.28e-04	38	41	2	34059773
Pubmed	Notch-Rbpj signaling is required for the development of noradrenergic neurons in the mouse locus coeruleus.	EOMES DBH	1.03e-03	40	41	2	22718343
Pubmed	Single-cell transcriptomic analysis of mouse neocortical development.	EOMES ASPM LHX9	1.07e-03	170	41	3	30635555
Cytoband	Ensembl 112 genes in cytogenetic band chr1q31	ASPM LHX9	2.07e-03	75	41	2	chr1q31
Cytoband	12q24.31	KNTC1 TMEM132B	2.35e-03	80	41	2	12q24.31
Coexpression	GSE5589_WT_VS_IL6_KO_LPS_STIM_MACROPHAGE_45MIN_DN	MYO1B CFAP54 CCNQ ADAM15 VARS1	1.47e-05	200	41	5	M6639
Disease	high altitude adaptation	KNTC1 LHX9	2.53e-04	17	41	2	EFO_0009105
Disease	tobacco smoke exposure measurement	CYB561D1 DBH	5.10e-04	24	41	2	EFO_0009115
Disease	chronic lymphocytic leukemia	EOMES TPK1 SFI1	6.10e-04	119	41	3	EFO_0000095
Disease	gestational age	PRKD1 VARS1 HCRTR1	9.37e-04	138	41	3	EFO_0005112
Disease	Anorectal Malformations	ECSIT CCNQ	1.49e-03	41	41	2	C3495676
Disease	candidiasis (implicated_via_orthology)	PRKD3 PRKD1	1.72e-03	44	41	2	DOID:1508 (implicated_via_orthology)
Disease	Malignant neoplasm of salivary gland	ASPM PRKD1	1.80e-03	45	41	2	C0220636
Disease	Salivary Gland Neoplasms	ASPM PRKD1	1.96e-03	47	41	2	C0036095
Disease	corpus callosum posterior volume measurement	PTCH2 CFAP54	2.39e-03	52	41	2	EFO_0010298
Disease	peripheral arterial disease, traffic air pollution measurement	PRKD1 ACER1 HCRTR1	2.48e-03	194	41	3	EFO_0004265, EFO_0007908
Disease	acute kidney failure (biomarker_via_orthology)	NOS1 PKD2	3.27e-03	61	41	2	DOID:3021 (biomarker_via_orthology)
Disease	Parkinson's disease (is_marker_for)	DBH NOS1	3.93e-03	67	41	2	DOID:14330 (is_marker_for)
Disease	risk-taking behaviour	PIGL MFSD13A TMEM132B ADAM15 LHX9	3.98e-03	764	41	5	EFO_0008579
Disease	Parkinson's disease (is_implicated_in)	DBH NOS1	5.03e-03	76	41	2	DOID:14330 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RAHVYLCNRPLWLKF	EOMES	266	O95936
REYFNIHLWLRCRLA	CFAP54	2376	Q96N23
FFFCSRKARIRLHWA	CYB561D1	81	Q8N8Q1
RLLCSFWQRIHFFYL	ACER1	191	Q8TDN7
WYRARLHQRLCQLKG	ADAM15	716	Q13444
AWRLLSRRHGAQLCY	DUS1L	31	Q6P1R4
WALLRDSYHGALCLR	CCNQ	171	Q8N1B3
WLLALCHRARNQSFF	DISP2	811	A7MBM2
SARRHNFLVYLQCWK	EFCAB12	386	Q6NXP0
RCWRAHKEYLAILKA	ASPM	2966	Q8IZT6
LACLQRLHVAWFYIH	PEX10	171	O60683
RHYWRLDSKCITLFQ	PRKD1	441	Q15139
RYYLLAVDKQWHLRC	LHX9	81	Q9NQ69
RKHAYICLAAIWAYA	OPN5	146	Q6U736
WRNGLAFCAILHRFY	EHBP1L1	1066	Q8N3D4
NLRKRHYWRLDSKCL	PRKD3	431	O94806
HYWRLDSKCLTLFQN	PRKD3	436	O94806
LVCAQYLWLRHRANF	KNTC1	561	P50748
CAVVLAQYLWFHRRS	METTL23	6	Q86XA0
LLACSNYHWQLSFLR	MAB21L3	226	Q8N8X9
LIYGAKHAWRNASRC	NOS1	406	P29475
ALDRWYAICHPLLFK	HCRTR1	141	O43613
CALDWRLYEHFNRTL	GAL3ST2	276	Q9H3Q3
RFWYCRLALNHKVLH	ELMO2	566	Q96JJ3
RLNYCRHVLAAWALG	DBH	291	P09172
CLYWNRHAGRLHLLY	ADGRG1	91	Q9Y653
GWLLCLRDRYSFFHK	DNAAF5	271	Q86Y56
LALDYLCRWAQKHKN	C7orf50	101	Q9BRJ6
HLNNLYFLSLCRRWG	MFSD13A	316	Q14CX5
FSLWLRNKCVYYHIL	ECSIT	291	Q9BQ95
YFHALCLRKWLYIQD	RNF139	566	Q8WU17
NRILGYRHFCNKLWN	VARS1	941	P26640
LHAAWDHYRIALLCK	SFI1	441	A8K8P3
LINCVAFAWKYRHKR	TMEM132B	916	Q14DG7
RLRHWVYLLCFSAGN	PIGL	66	Q9Y2B2
LPCARWNLAHFARYQ	PTCH2	661	Q9Y6C5
WLSLYISFCHLNKHR	TLCD5	16	Q6ZRR5
RIHKLHYFRSFWNCL	PKD2	496	Q13563
RYLRESAWKQHLNCY	ZNF131	296	P52739
GFRWKLAHFRYLCQS	WWP1	546	Q9H0M0
YFRHLWNKALLRACA	TPK1	31	Q9H3S4
LYSLAFNARFLRHLW	UBE3C	446	Q15386
RIFHLWRCKKYRDQF	MYO1B	916	O43795