Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium ion binding	SCN1A SCN3A SCN9A	4.66e-06	14	48	3	GO:0031402
GeneOntologyMolecularFunction	hexosyltransferase activity	UGT2A2 UGT2B15 UGT2B17 C1GALT1 MGAT5B POFUT2	1.10e-05	211	48	6	GO:0016758
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNG1 TMC2 HTR3A SCN1A SCN3A CNGB3 SCN9A	1.67e-05	343	48	7	GO:0005261
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN1A SCN3A SCN9A	3.26e-05	26	48	3	GO:0005248
GeneOntologyMolecularFunction	alkali metal ion binding	SCN1A SCN3A SCN9A	3.26e-05	26	48	3	GO:0031420
GeneOntologyMolecularFunction	glycosyltransferase activity	UGT2A2 UGT2B15 UGT2B17 C1GALT1 MGAT5B POFUT2	6.30e-05	288	48	6	GO:0016757
GeneOntologyMolecularFunction	glucuronosyltransferase activity	UGT2A2 UGT2B15 UGT2B17	8.08e-05	35	48	3	GO:0015020
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNG1 TMC2 HTR3A SCN1A SCN3A CNGB3 SCN9A	1.06e-04	459	48	7	GO:0005216
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	OTOGL GLB1L NAGLU FUCA2	1.09e-04	103	48	4	GO:0004553
GeneOntologyMolecularFunction	channel activity	CACNG1 TMC2 HTR3A SCN1A SCN3A CNGB3 SCN9A	2.41e-04	525	48	7	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNG1 TMC2 HTR3A SCN1A SCN3A CNGB3 SCN9A	2.44e-04	526	48	7	GO:0022803
GeneOntologyMolecularFunction	sodium channel activity	SCN1A SCN3A SCN9A	2.65e-04	52	48	3	GO:0005272
GeneOntologyMolecularFunction	hydrolase activity, acting on glycosyl bonds	OTOGL GLB1L NAGLU FUCA2	3.95e-04	144	48	4	GO:0016798
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	UGT2A2 UGT2B15 UGT2B17 MGAT5B	4.96e-04	153	48	4	GO:0008194
GeneOntologyMolecularFunction	transporter activity	CACNG1 TMC2 HTR3A SLC16A9 SCN1A SCN3A CNGB3 SCN9A LRP6 ATP8B1	8.32e-04	1289	48	10	GO:0005215
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	CACNG1 TMC2 HTR3A SCN1A SCN3A CNGB3 SCN9A	9.80e-04	664	48	7	GO:0008324
GeneOntologyMolecularFunction	gated channel activity	CACNG1 TMC2 HTR3A SCN1A CNGB3	1.21e-03	334	48	5	GO:0022836
GeneOntologyMolecularFunction	catalytic activity, acting on a glycoprotein	C1GALT1 MGAT5B	1.39e-03	23	48	2	GO:0140103
GeneOntologyMolecularFunction	transmembrane transporter activity	CACNG1 TMC2 HTR3A SLC16A9 SCN1A SCN3A CNGB3 SCN9A LRP6	1.77e-03	1180	48	9	GO:0022857
GeneOntologyMolecularFunction	retinoic acid binding	UGT2B15 UGT2B17	2.06e-03	28	48	2	GO:0001972
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNG1 TMC2 HTR3A SCN1A SCN3A CNGB3 SCN9A	2.70e-03	793	48	7	GO:0015075
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNG1 TMC2 SCN1A SCN3A SCN9A	5.04e-03	465	48	5	GO:0046873
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNG1 TMC2	5.47e-03	46	48	2	GO:0005245
GeneOntologyMolecularFunction	retinoid binding	UGT2B15 UGT2B17	5.95e-03	48	48	2	GO:0005501
GeneOntologyMolecularFunction	isoprenoid binding	UGT2B15 UGT2B17	6.19e-03	49	48	2	GO:0019840
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SCN1A SCN3A SCN9A	8.05e-03	171	48	3	GO:0015081
GeneOntologyMolecularFunction	cholesterol binding	OSBPL1A SOAT1	8.59e-03	58	48	2	GO:0015485
GeneOntologyMolecularFunction	lipid binding	SELP OSBPL1A UGT2B15 UGT2B17 ATP8B1 FITM1 SOAT1	8.88e-03	988	48	7	GO:0008289
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNG1 TMC2 SCN1A	9.54e-03	182	48	3	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNG1 TMC2 SCN1A	9.82e-03	184	48	3	GO:0022832
GeneOntologyBiologicalProcess	cellular glucuronidation	UGT2A2 UGT2B15 UGT2B17	1.63e-05	21	49	3	GO:0052695
GeneOntologyBiologicalProcess	steroid metabolic process	TECR OSBPL1A UGT2A2 UGT2B15 UGT2B17 ATP8B1 SOAT1	2.81e-05	376	49	7	GO:0008202
GeneOntologyBiologicalProcess	glucuronate metabolic process	UGT2A2 UGT2B15 UGT2B17	3.15e-05	26	49	3	GO:0019585
GeneOntologyBiologicalProcess	uronic acid metabolic process	UGT2A2 UGT2B15 UGT2B17	3.15e-05	26	49	3	GO:0006063
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN1A SCN3A SCN9A	8.51e-05	36	49	3	GO:0086010
GeneOntologyBiologicalProcess	biphenyl catabolic process	UGT2B15 UGT2B17	1.53e-04	8	49	2	GO:0070980
GeneOntologyBiologicalProcess	biphenyl metabolic process	UGT2B15 UGT2B17	2.46e-04	10	49	2	GO:0018879
GeneOntologyBiologicalProcess	sensory perception of mechanical stimulus	TMC2 OTOGL SCN1A SCN9A ATP8B1	2.47e-04	238	49	5	GO:0050954
GeneOntologyBiologicalProcess	bile acid metabolic process	OSBPL1A UGT2A2 ATP8B1	3.03e-04	55	49	3	GO:0008206
GeneOntologyBiologicalProcess	detection of mechanical stimulus involved in sensory perception	TMC2 SCN1A SCN9A	3.37e-04	57	49	3	GO:0050974
GeneOntologyBiologicalProcess	xenobiotic glucuronidation	UGT2B15 UGT2B17	3.59e-04	12	49	2	GO:0052697
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	SCN1A SCN3A SCN9A	4.32e-04	62	49	3	GO:0086002
GeneOntologyBiologicalProcess	neuronal action potential	SCN1A SCN3A SCN9A	4.53e-04	63	49	3	GO:0019228
GeneOntologyCellularComponent	cation channel complex	CACNG1 HTR3A SCN1A SCN3A CNGB3 SCN9A CATSPERG	2.06e-06	235	53	7	GO:0034703
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN1A SCN3A SCN9A	1.02e-05	17	53	3	GO:0001518
GeneOntologyCellularComponent	monoatomic ion channel complex	CACNG1 HTR3A SCN1A SCN3A CNGB3 SCN9A CATSPERG	4.51e-05	378	53	7	GO:0034702
GeneOntologyCellularComponent	sodium channel complex	SCN1A SCN3A SCN9A	5.37e-05	29	53	3	GO:0034706
GeneOntologyCellularComponent	transporter complex	CACNG1 HTR3A SCN1A SCN3A CNGB3 SCN9A ATP8B1 CATSPERG	6.82e-05	550	53	8	GO:1990351
GeneOntologyCellularComponent	transmembrane transporter complex	CACNG1 HTR3A SCN1A SCN3A CNGB3 SCN9A CATSPERG	3.35e-04	523	53	7	GO:1902495
GeneOntologyCellularComponent	plasma membrane protein complex	CACNG1 HTR3A SCN1A SCN3A SCN9A LRP6 CATSPERG TRDV1	7.57e-04	785	53	8	GO:0098797
GeneOntologyCellularComponent	vacuolar lumen	CTSF FMOD NAGLU FUCA2	1.07e-03	178	53	4	GO:0005775
GeneOntologyCellularComponent	platelet dense granule	SELP HPS4	1.28e-03	21	53	2	GO:0042827
GeneOntologyCellularComponent	lysosomal lumen	CTSF FMOD NAGLU	1.97e-03	98	53	3	GO:0043202
GeneOntologyCellularComponent	perinuclear endoplasmic reticulum	GDPD5 OSBPL1A	2.45e-03	29	53	2	GO:0097038
MousePheno	increased circulating calcium level	SAMD9L UGT2B15 UGT2B17 C1GALT1 TTC39A	3.72e-05	149	36	5	MP:0000194
MousePheno	increased calcium level	SAMD9L UGT2B15 UGT2B17 C1GALT1 TTC39A	5.54e-05	162	36	5	MP:0014537
Domain	LRRC37_N	LRRC37A LRRC37A3 LRRC37A2 LRRC37B	3.84e-11	4	48	4	IPR032754
Domain	LRRC37AB_C	LRRC37A LRRC37A3 LRRC37A2 LRRC37B	3.84e-11	4	48	4	PF14914
Domain	LRRC37AB_C	LRRC37A LRRC37A3 LRRC37A2 LRRC37B	3.84e-11	4	48	4	IPR029423
Domain	LRRC37	LRRC37A LRRC37A3 LRRC37A2 LRRC37B	3.84e-11	4	48	4	PF15779
Domain	LRRC37A/B-like	LRRC37A LRRC37A3 LRRC37A2 LRRC37B	3.84e-11	4	48	4	IPR015753
Domain	Na_trans_cytopl	SCN1A SCN3A SCN9A	3.17e-07	6	48	3	PF11933
Domain	Na_trans_cytopl	SCN1A SCN3A SCN9A	3.17e-07	6	48	3	IPR024583
Domain	Na_channel_asu	SCN1A SCN3A SCN9A	1.89e-06	10	48	3	IPR001696
Domain	Na_trans_assoc	SCN1A SCN3A SCN9A	1.89e-06	10	48	3	IPR010526
Domain	Na_trans_assoc	SCN1A SCN3A SCN9A	1.89e-06	10	48	3	PF06512
Domain	LRR_8	FMOD LRRC37A LGI2 LRRC37A3 LRRC37A2 LRRC37B	4.81e-06	171	48	6	PF13855
Domain	Leu-rich_rpt_typical-subtyp	FMOD LRRC37A LGI2 LRRC37A3 LRRC37A2 LRRC37B	5.87e-06	177	48	6	IPR003591
Domain	LRR_TYP	FMOD LRRC37A LGI2 LRRC37A3 LRRC37A2 LRRC37B	5.87e-06	177	48	6	SM00369
Domain	LRR_1	FMOD LRRC37A LGI2 LRRC37A3 LRRC37A2 LRRC37B	1.97e-05	219	48	6	PF00560
Domain	Leu-rich_rpt	FMOD LRRC37A LGI2 LRRC37A3 LRRC37A2 LRRC37B	6.50e-05	271	48	6	IPR001611
Domain	LRR	FMOD LRRC37A LRRC37A3 LRRC37A2 LRRC37B	1.61e-04	201	48	5	PS51450
Domain	-	FMOD LRRC37A LGI2 LRRC37A3 LRRC37A2 LRRC37B	1.64e-04	321	48	6	3.80.10.10
Domain	L_dom-like	FMOD LRRC37A LGI2 LRRC37A3 LRRC37A2 LRRC37B	1.85e-04	328	48	6	IPR032675
Domain	Ion_trans_dom	SCN1A SCN3A CNGB3 SCN9A	2.08e-04	114	48	4	IPR005821
Domain	Ion_trans	SCN1A SCN3A CNGB3 SCN9A	2.08e-04	114	48	4	PF00520
Domain	Glycoside_hydrolase_SF	GLB1L NAGLU FUCA2	3.41e-04	53	48	3	IPR017853
Domain	Channel_four-helix_dom	SCN1A SCN3A SCN9A	4.23e-04	57	48	3	IPR027359
Domain	-	SCN1A SCN3A SCN9A	4.23e-04	57	48	3	1.20.120.350
Domain	IQ	SCN1A SCN3A SCN9A	8.05e-04	71	48	3	PF00612
Domain	IQ	SCN1A SCN3A SCN9A	1.18e-03	81	48	3	SM00015
Domain	UDPGT	UGT2B15 UGT2B17	1.32e-03	21	48	2	PS00375
Domain	UDPGT	UGT2B15 UGT2B17	1.32e-03	21	48	2	PF00201
Domain	UDP_glucos_trans	UGT2B15 UGT2B17	1.32e-03	21	48	2	IPR002213
Domain	IQ_motif_EF-hand-BS	SCN1A SCN3A SCN9A	1.60e-03	90	48	3	IPR000048
Domain	IQ	SCN1A SCN3A SCN9A	1.76e-03	93	48	3	PS50096
Domain	THIOL_PROTEASE_CYS	CTSF CAPN11	2.02e-03	26	48	2	PS00139
Domain	THIOL_PROTEASE_ASN	CTSF CAPN11	2.18e-03	27	48	2	PS00640
Domain	THIOL_PROTEASE_HIS	CTSF CAPN11	2.18e-03	27	48	2	PS00639
Domain	Pept_cys_AS	CTSF CAPN11	2.34e-03	28	48	2	IPR000169
Domain	-	GLB1L FUCA2	3.65e-03	35	48	2	3.20.20.80
Domain	Glyco_hydro_catalytic_dom	GLB1L FUCA2	4.29e-03	38	48	2	IPR013781
Domain	PMP22_Claudin	CACNG1 PERP	4.74e-03	40	48	2	PF00822
Domain	PMP22/EMP/MP20/Claudin	CACNG1 PERP	5.97e-03	45	48	2	IPR004031
Domain	EF-hand-dom_pair	SCN1A SCN3A SCN9A CAPN11	6.25e-03	287	48	4	IPR011992
Domain	Sushi	SELP SUSD2	7.90e-03	52	48	2	PF00084
Domain	CCP	SELP SUSD2	8.50e-03	54	48	2	SM00032
Domain	SUSHI	SELP SUSD2	9.12e-03	56	48	2	PS50923
Domain	Sushi_SCR_CCP_dom	SELP SUSD2	9.43e-03	57	48	2	IPR000436
Pathway	REACTOME_GLUCURONIDATION	UGT2A2 UGT2B15 UGT2B17	4.77e-05	24	42	3	MM14599
Pathway	REACTOME_GLUCURONIDATION	UGT2A2 UGT2B15 UGT2B17	5.40e-05	25	42	3	M17787
Pathway	WP_GLUCURONIDATION	UGT2A2 UGT2B15 UGT2B17	5.40e-05	25	42	3	MM15820
Pathway	WP_GLUCURONIDATION	UGT2A2 UGT2B15 UGT2B17	6.10e-05	26	42	3	M39404
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN1A SCN3A SCN9A	1.04e-04	31	42	3	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN1A SCN3A SCN9A	1.15e-04	32	42	3	M27455
Pathway	REACTOME_ASPIRIN_ADME	UGT2A2 UGT2B15 UGT2B17	2.99e-04	44	42	3	M45014
Pathway	REACTOME_ASPIRIN_ADME	UGT2A2 UGT2B15 UGT2B17	3.20e-04	45	42	3	MM15694
Pathway	REACTOME_KERATAN_SULFATE_DEGRADATION	FMOD GLB1L	8.88e-04	15	42	2	M691
Pathway	REACTOME_KERATAN_SULFATE_DEGRADATION	FMOD GLB1L	8.88e-04	15	42	2	MM14799
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A LRRC37A3 LRRC37A2 LRRC37B	1.00e-09	10	53	4	23064749
Pubmed	Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).	SCN1A SCN3A SCN9A	3.34e-09	3	53	3	33895391
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A LRRC37A3 LRRC37A2	1.34e-08	4	53	3	22419166
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	SCN1A SCN3A SCN9A	3.33e-08	5	53	3	8812438
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN3A SCN9A	6.66e-08	6	53	3	23652591
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN1A SCN3A SCN9A	2.79e-07	9	53	3	16382098
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN1A SCN3A SCN9A	9.45e-07	13	53	3	15123669
Pubmed	Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study.	UGT2B15 UGT2B17	2.28e-06	2	53	2	24267955
Pubmed	Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes.	SAMD9L SAMD9	2.28e-06	2	53	2	34621053
Pubmed	Differential expression of the androgen-conjugating UGT2B15 and UGT2B17 enzymes in prostate tumor cells during cancer progression.	UGT2B15 UGT2B17	2.28e-06	2	53	2	22170718
Pubmed	Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells.	SAMD9L SAMD9	2.28e-06	2	53	2	33731850
Pubmed	Germline loss-of-function SAMD9 and SAMD9L alterations in adult myelodysplastic syndromes.	SAMD9L SAMD9	2.28e-06	2	53	2	30322869
Pubmed	Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells.	UGT2B15 UGT2B17	2.28e-06	2	53	2	32660355
Pubmed	Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.	SCN1A SCN3A	2.28e-06	2	53	2	27690330
Pubmed	[Pancytopenia in children caused by SAMD9/9L mutation: 5 cases report and literature review].	SAMD9L SAMD9	2.28e-06	2	53	2	37357006
Pubmed	Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5.	UGT2B15 UGT2B17	2.28e-06	2	53	2	3105095
Pubmed	UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells.	UGT2B15 UGT2B17	2.28e-06	2	53	2	17848572
Pubmed	Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.	SCN1A SCN3A	2.28e-06	2	53	2	23965409
Pubmed	Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17.	UGT2B15 UGT2B17	2.28e-06	2	53	2	27496708
Pubmed	The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence.	UGT2B15 UGT2B17	2.28e-06	2	53	2	1909870
Pubmed	Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation.	UGT2B15 UGT2B17	2.28e-06	2	53	2	28228532
Pubmed	Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.	SCN1A SCN3A	2.28e-06	2	53	2	24990319
Pubmed	Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.	SCN3A SCN9A	2.28e-06	2	53	2	25172946
Pubmed	Androgen glucuronidation: an unexpected target for androgen deprivation therapy, with prognosis and diagnostic implications.	UGT2B15 UGT2B17	2.28e-06	2	53	2	24121496
Pubmed	A paralogous pair of mammalian host restriction factors form a critical host barrier against poxvirus infection.	SAMD9L SAMD9	2.28e-06	2	53	2	29447249
Pubmed	Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium.	UGT2B15 UGT2B17	2.28e-06	2	53	2	15666817
Pubmed	SAMD9 and SAMD9L in inherited predisposition to ataxia, pancytopenia, and myeloid malignancies.	SAMD9L SAMD9	2.28e-06	2	53	2	29535429
Pubmed	Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse.	SAMD9L SAMD9	2.28e-06	2	53	2	17407603
Pubmed	Mouse UDP glucuronosyltransferase. cDNA and complete amino acid sequence and regulation.	UGT2B15 UGT2B17	2.28e-06	2	53	2	3117546
Pubmed	Viral host range factors antagonize pathogenic SAMD9 and SAMD9L variants.	SAMD9L SAMD9	2.28e-06	2	53	2	36894052
Pubmed	The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men.	UGT2B15 UGT2B17	2.28e-06	2	53	2	17698910
Pubmed	Voltage-gated sodium channels in taste bud cells.	SCN3A SCN9A	6.83e-06	3	53	2	19284629
Pubmed	PARP14 correlates with GBM proliferation and poor prognosis by elevating expression of SAMD/SAMD9L.	SAMD9L SAMD9	6.83e-06	3	53	2	37612499
Pubmed	Germline predisposition in myeloid neoplasms: Unique genetic and clinical features of GATA2 deficiency and SAMD9/SAMD9L syndromes.	SAMD9L SAMD9	6.83e-06	3	53	2	33038986
Pubmed	Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism.	UGT2B15 UGT2B17	6.83e-06	3	53	2	19572376
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN1A SCN3A	6.83e-06	3	53	2	12610651
Pubmed	Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines.	UGT2B15 UGT2B17	6.83e-06	3	53	2	26163549
Pubmed	Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells.	UGT2B15 UGT2B17	6.83e-06	3	53	2	17988216
Pubmed	Prevalence of germline GATA2 and SAMD9/9L variants in paediatric haematological disorders with monosomy 7.	SAMD9L SAMD9	6.83e-06	3	53	2	32770553
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN1A SCN3A	6.83e-06	3	53	2	23859570
Pubmed	Forkhead box protein A1 regulates UDP-glucuronosyltransferase 2B15 gene transcription in LNCaP prostate cancer cells.	UGT2B15 UGT2B17	6.83e-06	3	53	2	20736324
Pubmed	Tissue distribution and relative gene expression of UDP-glucuronosyltransferases (2B7, 2B15, 2B17) in the human fetus.	UGT2B15 UGT2B17	6.83e-06	3	53	2	23223495
Pubmed	Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.	SCN3A SCN9A	6.83e-06	3	53	2	19699781
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN1A SCN3A	6.83e-06	3	53	2	14973256
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN1A SCN3A	6.83e-06	3	53	2	18784617
Pubmed	Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer.	UGT2B15 UGT2B17	6.83e-06	3	53	2	26385605
Pubmed	Androgen receptor mediates the expression of UDP-glucuronosyltransferase 2 B15 and B17 genes.	UGT2B15 UGT2B17	6.83e-06	3	53	2	18302198
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN1A SCN3A	6.83e-06	3	53	2	17544618
Pubmed	Genetic variations in UGT2B28, UGT2B17, UGT2B15 genes and the risk of prostate cancer: A case-control study.	UGT2B15 UGT2B17	6.83e-06	3	53	2	28882566
Pubmed	The nuclear receptor Shp regulates morphine withdrawal syndrome via modulation of Ugt2b expression in mice.	UGT2B15 UGT2B17	6.83e-06	3	53	2	30689982
Pubmed	Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25.	SELP IL7R	6.83e-06	3	53	2	19289576
Pubmed	GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.	SCN1A SCN3A	6.83e-06	3	53	2	27816501
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN1A SCN3A	1.36e-05	4	53	2	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN1A SCN3A	1.36e-05	4	53	2	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN1A SCN3A	1.36e-05	4	53	2	29578003
Pubmed	Calcitrol (1alpha,25-dihydroxyvitamin D3) inhibits androgen glucuronidation in prostate cancer cells.	UGT2B15 UGT2B17	1.36e-05	4	53	2	18281521
Pubmed	Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients.	UGT2B15 UGT2B17	1.36e-05	4	53	2	26176234
Pubmed	Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.	SCN1A SCN3A	1.36e-05	4	53	2	35801810
Pubmed	Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.	SCN1A SCN9A	1.36e-05	4	53	2	22260870
Pubmed	Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.	SCN1A SCN3A	1.36e-05	4	53	2	8974318
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	SCN1A SCN3A	2.27e-05	5	53	2	1679748
Pubmed	Early development of electrical excitability in the mouse enteric nervous system.	SCN3A SCN9A	2.27e-05	5	53	2	22875929
Pubmed	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.	SCN1A SCN3A	2.27e-05	5	53	2	24337656
Pubmed	Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).	ANKRD31 LRRC37A SCN1A	2.71e-05	38	53	3	22952603
Pubmed	Steroidogenic enzymes and stem cell markers are upregulated during androgen deprivation in prostate cancer.	UGT2B15 UGT2B17	3.40e-05	6	53	2	21365123
Pubmed	Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene.	SCN3A SCN9A	3.40e-05	6	53	2	9143501
Pubmed	Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.	UGT2B15 UGT2B17	4.76e-05	7	53	2	26074487
Pubmed	Core 1-derived O-glycans are essential E-selectin ligands on neutrophils.	SELP C1GALT1	4.76e-05	7	53	2	20439727
Pubmed	Pain without nociceptors? Nav1.7-independent pain mechanisms.	SCN3A SCN9A	4.76e-05	7	53	2	24440715
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CACNG1 SCN1A SCN3A SCN9A	6.15e-05	139	53	4	16985003
Pubmed	Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry.	UGT2B15 UGT2B17	6.34e-05	8	53	2	22579593
Pubmed	Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.	UGT2B15 UGT2B17	6.34e-05	8	53	2	32093886
Pubmed	Significant determinants of mouse pain behaviour.	SCN3A SCN9A	6.34e-05	8	53	2	25101983
Pubmed	The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.	UGT2B15 UGT2B17	6.34e-05	8	53	2	18719240
Pubmed	Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States.	UGT2B15 UGT2B17	6.34e-05	8	53	2	20142249
Pubmed	Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse.	SCN3A SCN9A	8.15e-05	9	53	2	8854872
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN1A SCN3A	8.15e-05	9	53	2	15746173
Pubmed	Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.	SCN1A SCN3A	1.49e-04	12	53	2	8169823
Pubmed	Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.	UGT2B15 UGT2B17	1.49e-04	12	53	2	20308471
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN1A SCN3A	1.49e-04	12	53	2	30175250
Pubmed	Confirmation of quantitative trait loci for alcohol preference in mice.	SCN1A SCN3A	2.36e-04	15	53	2	9726281
Pubmed	Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response.	IGHV3-33 IGHV4-34	5.16e-04	22	53	2	2499654
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	CACNG1 SAMD9L SCN9A ZNF214 ATP8B1 SOAT1	6.02e-04	686	53	6	29987050
Cytoband	6q24	PERP FUCA2	3.65e-05	8	53	2	6q24
Cytoband	2q24	SCN3A SCN9A	7.14e-05	11	53	2	2q24
Cytoband	4q13	UGT2B15 UGT2B17	1.36e-04	15	53	2	4q13
Cytoband	7q21.2	SAMD9L SAMD9	1.36e-04	15	53	2	7q21.2
Cytoband	Ensembl 112 genes in cytogenetic band chr2q24	SCN1A SCN3A SCN9A	4.38e-04	127	53	3	chr2q24
Cytoband	Ensembl 112 genes in cytogenetic band chr4q13	UGT2A2 UGT2B15 UGT2B17	8.11e-04	157	53	3	chr4q13
Cytoband	12p13.2	LRP6 CLEC12B	1.25e-03	45	53	2	12p13.2
Cytoband	17q21.31	LRRC37A LRRC37A2	4.09e-03	82	53	2	17q21.31
Cytoband	Ensembl 112 genes in cytogenetic band chr17q24	CACNG1 LRRC37A3	5.79e-03	98	53	2	chr17q24
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN3A SCN9A	7.13e-07	9	38	3	1203
GeneFamily	UDP glucuronosyltransferases	UGT2A2 UGT2B15 UGT2B17	4.07e-05	32	38	3	363
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELP SUSD2	6.38e-03	57	38	2	1179
CoexpressionAtlas	JC_fibro_top-relative-expression-ranked_500_k-means-cluster#3	SAMD9L FMOD SCN3A SCN9A ATP8B1 IL7R	8.63e-06	206	50	6	JC_fibro_500_K3
CoexpressionAtlas	DevelopingKidney_e15.5_Proximal Tubules_emap-28005_top-relative-expression-ranked_500	SAMD9L SLC16A9 SUSD2 GLB1L PERP UGT2B15 UGT2B17	3.32e-05	389	50	7	gudmap_developingKidney_e15.5_Proximal Tubules_500
CoexpressionAtlas	kidney_adult_RenalCapsule_k-means-cluster#3_top-relative-expression-ranked_1000	SAMD9L SUSD2 UGT2B15 FUCA2	4.36e-05	83	50	4	gudmap_kidney_adult_RenalCapsule_k3_1000
CoexpressionAtlas	kidney_adult_RenCorpuscGlomer_k-means-cluster#4_top-relative-expression-ranked_500	SAMD9L UGT2B15 FUCA2	4.77e-05	30	50	3	gudmap_kidney_adult_RenCorpuscGlomer_k4_500
CoexpressionAtlas	DevelopingKidney_e15.5_early proxim tubul_emap-28005_k-means-cluster#4_top-relative-expression-ranked_1000	SAMD9L SLC16A9 GLB1L PERP UGT2B17	5.34e-05	173	50	5	gudmap_developingKidney_e15.5_early proxim tubul_1000_k4
CoexpressionAtlas	DevelopingKidney_e15.5_early proxim tubul_emap-28005_top-relative-expression-ranked_1000	SAMD9L SLC16A9 SUSD2 GLB1L NAGLU PERP UGT2B15 UGT2B17 FUCA2	7.84e-05	784	50	9	gudmap_developingKidney_e15.5_early proxim tubul_1000
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMC2 OTOGL SCN1A CNGB3 SCN9A	8.22e-07	145	53	5	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOGL SCN3A CNGB3 RPS10 SCN9A	1.75e-06	169	53	5	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	systemic_lupus_erythematosus-flare\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SAMD9L SAMD9 RPS10 C1GALT1 IL7R	3.79e-06	198	53	5	4c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell	CTRL-Lymphoid-pDC\|CTRL / Disease state, Lineage and Cell class	SELP SCN3A SCN9A TTC39A	2.27e-05	139	53	4	bbc10812b0c5b8c85e78171c12316becde8895c3
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast-MyoFB-1\|E18.5-samps / Age Group, Lineage, Cell class and subclass	SCN9A IGSF9B FAIM2 MGAT5B	2.68e-05	145	53	4	ac41c6c02b7d78162b86222983688f54d04ac47d
ToppCell	Healthy_donor-B_cell\|World / disease group, cell group and cell class (v2)	HTR3A ATP8B1 TRDV1 IGHV4-34	3.06e-05	150	53	4	a2dfed562de7f58f902b547acec5a13853c80c4c
ToppCell	Healthy_donor-B_cell\|Healthy_donor / disease group, cell group and cell class (v2)	HTR3A SCN3A TRDV1 IGHV4-34	3.22e-05	152	53	4	5768edfde8010324d8594815e73bbfba2c3045f3
ToppCell	CV-Healthy-3\|Healthy / Virus stimulation, Condition and Cluster	ANKRD31 SUSD2 PERP ATP8B1	3.39e-05	154	53	4	26bf81a86700db7e65c2384ffe94ed4253ea4047
ToppCell	Int-URO-Lymphocyte-T_NK-CD8_TCM\|Int-URO / Disease, Lineage and Cell Type	ANKRD31 CTSF PERP IL7R	3.75e-05	158	53	4	edcc5a26d4571b179f3ae538fed23b661e4677dd
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRRC37A LGI2 SCN3A IL7R	4.55e-05	166	53	4	26f3d5e5e30b63b09b89cda23c423d12d887631f
ToppCell	343B-Endothelial_cells-Endothelial-D\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SELP SCN1A RPS10 ATP8B1	4.99e-05	170	53	4	52fdf93c2803fecb2a640ef4e0b257786f3d4cb1
ToppCell	343B-Endothelial_cells-Endothelial-D-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SELP SCN1A RPS10 ATP8B1	4.99e-05	170	53	4	263e98aa1c49493cc262b2608c6582930841cb10
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal-skeletal_muscle_satellite_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOGL RPS10 SCN9A FITM1	5.46e-05	174	53	4	f230d23618a6487f2664efb2c677e0a4559e2bf4
ToppCell	Control-Lymphoid_P-Plasmablast\|Control / Disease group, lineage and cell class	IGHV3-33 PERP UGT2B17 IGHV4-34	5.71e-05	176	53	4	4b4416f342b732d2cc60133838728880326257d8
ToppCell	Control-Lymphoid_P\|Control / Disease group, lineage and cell class	IGHV3-33 PERP UGT2B17 IGHV4-34	5.71e-05	176	53	4	d895a6b295cd649273ff80ad7785a3e0ae4c728a
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-T4_reg-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SAMD9 TECR RPS10 IL7R	5.96e-05	178	53	4	90dedb3cef9b01907b9f8eec64218d6d2072be1f
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-T4_reg\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SAMD9 TECR RPS10 IL7R	5.96e-05	178	53	4	d6312286bf6cc5b107ccd7adb583d9667d4e1d21
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGHV3-33 PERP UGT2B17 IGHV4-34	6.09e-05	179	53	4	837ed81f18257f444eaeadc4fac89deedd4e3061
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGHV3-33 PERP UGT2B17 IGHV4-34	6.09e-05	179	53	4	b6ee4f41d8fb5f047b7bdd8489dda0a89fc6d43f
ToppCell	PCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TMC2 HTR3A SCN3A FAIM2	6.78e-05	184	53	4	571136c832cb8c08457744152231537aa8e8abd7
ToppCell	healthy_donor-Lymphocytic-Plasma_cell-IgA_Plasmablast\|healthy_donor / Disease condition, Lineage, Cell class and subclass	IGHV3-33 PERP UGT2B17 IGHV4-34	7.07e-05	186	53	4	e2c050ba02e1f84f0b7258dc92e7ff6ab349ff67
ToppCell	healthy_donor-Lymphocytic-Plasma_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	IGHV3-33 PERP UGT2B17 IGHV4-34	7.37e-05	188	53	4	bd53b0371154cff680226897b61c9809a239d1b6
ToppCell	PCW_05-06-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	HTR3A SCN3A SCN9A FAIM2	7.83e-05	191	53	4	3a5081dc542ac6262acfe5f8084a86616fee8082
ToppCell	droplet-Bladder-Unstain-18m-Epithelial-basal_bladder_epithelial_cell_(Krt5+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS10 PERP IGSF9B CAPN11	7.83e-05	191	53	4	49068e3b7d265d4767d7b3c79d455dbc2fd8c6cd
ToppCell	COVID-19_Moderate-CD4+_T_activated\|World / disease group, cell group and cell class	SAMD9L SAMD9 RPS10 IL7R	8.15e-05	193	53	4	c2a2a2c14a7085690262db5c2a70e38db67dee18
ToppCell	Control-Lymphoid-Plasma,_B_cells\|Control / Condition, Lineage and Cell class	IGHV3-33 HTR3A SCN3A IGHV4-34	8.32e-05	194	53	4	31fff4361ebed6308b1e6b2b705ee6e0a695bd0c
ToppCell	Control-B_cell\|Control / Disease group,lineage and cell class （2021.01.30）	IGHV3-33 HTR3A SCN3A IGHV4-34	8.32e-05	194	53	4	8388fe4df3461d85b21bd6847a4d32c030aaece4
ToppCell	BAL-Control-Lymphocyte-B\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGHV3-33 HTR3A SCN3A IGHV4-34	8.32e-05	194	53	4	1537e2285d0a8d0a4175dd0b8b1d1ccd887229fc
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SAMD9L IGHV4-34 IL7R CAPN11	8.49e-05	195	53	4	c96755d2eb98112b703b5dbee9c88730ace7dcbf
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SAMD9L SAMD9 PERP IL7R	8.49e-05	195	53	4	662b50a2aa97373bf343b88caace9717049c722a
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SAMD9L SAMD9 PERP IL7R	8.49e-05	195	53	4	9b7157b5e4b81bc35b0e6d9b954279160ea57324
ToppCell	systemic_lupus_erythematosus-treated\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SAMD9L SAMD9 RPS10 C1GALT1	9.00e-05	198	53	4	8165ff735095c52994fb5057d89be93cc378b7da
ToppCell	Control-Control-Lymphocyte-T/NK-CD4+_T_activated\|Control / Disease, condition lineage and cell class	SAMD9L SAMD9 LRRC37A IL7R	9.00e-05	198	53	4	ee71543559836fd59adc0da877b2ca538cba60cb
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PERP TTC39A ATP8B1 FITM1	9.18e-05	199	53	4	fb9550bbb1fa206c3132e0a21a646eedb41c281a
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-goblet\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PERP TTC39A ATP8B1 FITM1	9.18e-05	199	53	4	440f47e320c75f49ef47139b46962de68cee8320
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SCN1A SCN9A LRP6 FAIM2	9.18e-05	199	53	4	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD8+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	SAMD9L SAMD9 TECR RPS10	9.36e-05	200	53	4	7751affe353a5208ffad7a58308c588050e77243
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-CD8+_Tcm\|Int-URO / Disease, condition lineage and cell class	ANKRD31 CTSF PERP IL7R	9.36e-05	200	53	4	9535fd16a962d57e80319bc26093617e04c8b2a8
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SAMD9L OSBPL1A SCN9A IL7R	9.36e-05	200	53	4	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	VE\|World / Condition, Cell_class and T cell subcluster	SAMD9L SAMD9 RPS10 IL7R	9.36e-05	200	53	4	8ae7cb81de3ffac5acdf3466d4b516d80cac95d3
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7-Tac2-Excitatory_Neuron.Slc17a7.Tac2.Wif1_(Medial_habenular,_lateral_portion)\|Thalamus / BrainAtlas - Mouse McCarroll V32	SELP CACNG1 FITM1	1.19e-04	80	53	3	da18df34b4f630fe4fe3110e3c3c3602aef92aab
ToppCell	lung-Type_I_Pneumocytes\|lung / shred on tissue and cell subclass	SLC16A9 SUSD2 LRP6	1.28e-04	82	53	3	6023212a51f8b3e05e6c3dcf4e8fbf53ba696fb2
Drug	diphenhydramine	SELP HTR3A HPS4 SCN3A SCN9A	6.39e-07	75	50	5	CID000003100
Drug	indoxacarb	SCN3A SCN9A ATP8B1 FUCA2	4.05e-06	49	50	4	CID000107720
Drug	Zonisamide	SCN1A SCN3A SCN9A	6.63e-06	17	50	3	DB00909
Drug	AC1MPID3	SELP FUCA2 POFUT2	9.42e-06	19	50	3	CID003411617
Drug	N-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide	SCN3A SCN9A	1.42e-05	3	50	2	ctd:C561228
Drug	methoxyresorufin	HPS4 NAGLU UGT2B15 UGT2B17	1.60e-05	69	50	4	CID000119220
Drug	1, 3-diallylurea	FMOD HPS4 SCN3A SCN9A	2.11e-05	74	50	4	CID000074537
Drug	AC1L1KGG	SELP C1GALT1 IL7R	2.22e-05	25	50	3	CID000005489
Drug	AC1L1MOZ	SCN3A NAGLU SCN9A	2.81e-05	27	50	3	CID000031958
Drug	pentoxyresorufin	HPS4 NAGLU UGT2B15 UGT2B17	4.00e-05	87	50	4	CID000107683
Drug	NSC93767	HTR3A SCN3A SCN9A	4.73e-05	32	50	3	CID000005658
Drug	lacto-N-tetraose	HPS4 FUCA2 POFUT2	4.73e-05	32	50	3	CID000440993
Drug	lorcaserin	UGT2B15 UGT2B17	7.05e-05	6	50	2	ctd:C506658
Drug	todralazine	HPS4 FUCA2	7.05e-05	6	50	2	CID000005501
Drug	3'-sialyl LewisX	SELP HPS4 C1GALT1 FUCA2 POFUT2	7.12e-05	197	50	5	CID000643990
Drug	Monobenzone [103-16-2]; Up 200; 20uM; MCF7; HT_HG-U133A	GDPD5 CTSF HPS4 CNGB3 TTC39A	7.12e-05	197	50	5	5312_UP
Drug	Calciferol [50-14-6]; Up 200; 10uM; PC3; HT_HG-U133A	CTSF CACNG1 FMOD HTR3A FAIM2	7.29e-05	198	50	5	6746_UP
Drug	butein; Up 200; 10uM; PC3; HG-U133A	GDPD5 HTR3A LRP6 FAIM2 SOAT1	7.47e-05	199	50	5	582_UP
Drug	UDP-N-acetylglucosamine	NAGLU UGT2B15 UGT2B17 C1GALT1 MGAT5B	8.20e-05	203	50	5	CID000001167
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN3A SCN9A	6.14e-07	10	52	3	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN3A SCN9A	6.14e-07	10	52	3	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN3A SCN9A	1.12e-06	12	52	3	DOID:0060170 (implicated_via_orthology)
Disease	Familial monosomy 7 syndrome	SAMD9L SAMD9	3.05e-06	2	52	2	cv:C5681220
Disease	Early Infantile Epileptic Encephalopathy 6	SCN1A SCN9A	3.05e-06	2	52	2	C4551549
Disease	anxiety disorder (implicated_via_orthology)	SCN1A SCN3A SCN9A	7.76e-06	22	52	3	DOID:2030 (implicated_via_orthology)
Disease	cholic acid glucuronide measurement	UGT2B15 UGT2B17	9.13e-06	3	52	2	EFO_0800574
Disease	X-25937 measurement	UGT2B15 UGT2B17	1.82e-05	4	52	2	EFO_0800937
Disease	X-24574 measurement	UGT2B15 UGT2B17	6.36e-05	7	52	2	EFO_0800897
Disease	Early Childhood Epilepsy, Myoclonic	SCN1A SCN9A	8.47e-05	8	52	2	C0393695
Disease	Idiopathic Myoclonic Epilepsy	SCN1A SCN9A	8.47e-05	8	52	2	C0338478
Disease	Symptomatic Myoclonic Epilepsy	SCN1A SCN9A	8.47e-05	8	52	2	C0338479
Disease	Myoclonic Encephalopathy	SCN1A SCN9A	8.47e-05	8	52	2	C0438414
Disease	Benign Infantile Myoclonic Epilepsy	SCN1A SCN9A	8.47e-05	8	52	2	C0751120
Disease	deoxycholic acid glucuronide measurement	UGT2B15 UGT2B17	8.47e-05	8	52	2	EFO_0800575
Disease	Myoclonic Absence Epilepsy	SCN1A SCN9A	8.47e-05	8	52	2	C0393703
Disease	Myoclonic Epilepsy	SCN1A SCN9A	1.09e-04	9	52	2	C0014550
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN1A SCN9A	1.09e-04	9	52	2	C3502809
Disease	Epilepsy, Myoclonic, Infantile	SCN1A SCN9A	1.36e-04	10	52	2	C0917800
Disease	4-androsten-3alpha,17alpha-diol monosulfate (3) measurement	UGT2B15 UGT2B17	1.36e-04	10	52	2	EFO_0022090
Disease	DNA repair protein RAD51 homolog 4 measurement	UGT2B15 UGT2B17	1.66e-04	11	52	2	EFO_0801531
Disease	Myoclonic Astatic Epilepsy	SCN1A SCN9A	1.66e-04	11	52	2	C0393702
Disease	5alpha-androstan-3beta,17beta-diol monosulfate (2) measurement	UGT2B15 UGT2B17	1.99e-04	12	52	2	EFO_0800291
Disease	androstenediol (3alpha, 17alpha) monosulfate (3) measurement	UGT2B15 UGT2B17	2.35e-04	13	52	2	EFO_0800293
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN9A	2.35e-04	13	52	2	C0751122
Disease	X-19141 measurement	UGT2B15 UGT2B17	2.35e-04	13	52	2	EFO_0800799
Disease	response to methotrexate, aspartate aminotransferase measurement	SELP TMC2	2.73e-04	14	52	2	EFO_0004736, GO_0031427
Disease	5alpha-androstan-3alpha,17alpha-diol monosulfate measurement	UGT2B15 UGT2B17	2.73e-04	14	52	2	EFO_0800283
Disease	5alpha-androstan-3alpha,17beta-diol monosulfate (1) measurement	UGT2B15 UGT2B17	4.58e-04	18	52	2	EFO_0800288
Disease	etiocholanolone glucuronide measurement	UGT2B15 UGT2B17	5.11e-04	19	52	2	EFO_0800362
Disease	androsterone glucuronide measurement	UGT2B15 UGT2B17	5.67e-04	20	52	2	EFO_0800317
Disease	X-24947 measurement	UGT2B15 UGT2B17	6.88e-04	22	52	2	EFO_0800910
Disease	epiandrosterone sulfate measurement	UGT2B15 UGT2B17	8.90e-04	25	52	2	EFO_0021120
Disease	androsterone sulfate measurement	UGT2B15 UGT2B17	1.55e-03	33	52	2	EFO_0021117
Disease	granulocyte colony-stimulating factor measurement	LGI2 IGSF9B	1.65e-03	34	52	2	EFO_0008142

Protein segments in the cluster

Peptide	Gene	Start	Entry
WWANNKQDQDYYFFL	CATSPERG	711	Q6ZRH7
TTYIWYRQYWTDEFL	HTR3A	81	P46098
YKSYWHTTFYEGSWR	CAPN11	386	Q9UMQ6
YWEAQVGNSSWYLYD	ATP8B1	361	O43520
YYQNVCTQSYSFVWW	NAGLU	131	P54802
TVWIEYYYSWSFACA	CACNG1	171	Q06432
NSYVTWNYAWSKVTY	ANKRD31	1756	Q8N7Z5
GWFYDWTQTYDIAFY	SLC16A9	451	Q7RTY1
WWFHYLRSQQSTYYD	FMOD	26	Q06828
YISYIDGNVWKAYSW	LRRC37A3	876	O60309
KDYVQANPGWYWASY	FAIM2	131	Q9BWQ8
YISYIDGNVWKAYSW	LRRC37A2	876	A6NM11
YISYIDGNVWKAYSW	LRRC37A	876	A6NMS7
SASWWNYFFLYDGSK	HPS4	11	Q9NQG7
YATLHGYRTNWGYWN	MGAT5B	406	Q3V5L5
TYIYNWAYGFGWAAT	PERP	146	Q96FX8
FGLTQYQDYIYWTDW	LRP6	836	O75581
YISYLDGNVWKAYSW	LRRC37B	566	Q96QE4
EFNWYLYNRMGYWSD	GDPD5	71	Q8WTR4
HYFKGFWSEWSPSYY	IL7R	211	P16871
YNGAQDWIYSGSYWD	OSBPL1A	926	Q9BXW6
DWIYSGSYWDRNYFN	OSBPL1A	931	Q9BXW6
QYWNSTGFLAWLYNE	FUCA2	236	Q9BTY2
TIKSIGHQWYWTYEY	MT-CO2	96	P00403
GTFAWYLTYGSWYHQ	FITM1	256	A5D6W6
VNSEYYTGWLDYWGQ	GLB1L	261	Q6UWU2
NSWGTDWGEKGYYYL	CTSF	451	Q9UBX1
AWTYHYSTKAYSWNI	SELP	41	P16109
IKGYLPRTFWYWNYN	C1GALT1	276	Q9NS00
FCEKMWINYTYFWNY	OTOGL	1761	Q3ZCN5
WINYTYFWNYECDAL	OTOGL	1766	Q3ZCN5
WVAVIWYDGSNKYYA	IGHV3-33	66	P01772
YGGSFSGYYWSWIRQ	IGHV4-34	51	P06331
YSQEWTAKWSYLYPL	SUSD2	206	Q9UGT4
DWWNSTSYSNYYRTW	SOAT1	406	P35610
WNSKGFYSYQSLHEW	LGI2	356	Q8N0V4
LYSQDKHEYYRGWFW	POFUT2	166	Q9Y2G5
GKVSWWNFYFSSENY	SAMD9L	691	Q8IVG5
EDFYRGGKVSWWNFY	SAMD9	681	Q5K651
IAYGYKTYFTNAWCW	SCN9A	1246	Q15858
AYGFQTYFTNAWCWL	SCN3A	1261	Q9NY46
WVAYGYQTYFTNAWC	SCN1A	1271	P35498
YQTYFTNAWCWLDFL	SCN1A	1276	P35498
LNCLYETSWWSYYIF	TRDV1	41	A0A1B0GX56
ETSWWSYYIFWYKQL	TRDV1	46	A0A1B0GX56
MWQWYQNSCYYFTTN	CLEC12B	146	Q2HXU8
YYWASNYEGIGTTRW	CNGB3	371	Q9NQW8
GYVKEQFAWRHFYWY	RPS10	56	P46783
YTWYWQDENVYFQND	IGSF9B	261	Q9UPX0
YINIYKTVWWYPYNH	TMEM39A	91	Q9NV64
TRYAWKNGNLKWYYY	ZHX1	711	Q9UKY1
TYYWGFAAWMAYYIN	TECR	166	Q9NZ01
RWIYGVSKNTFWSYF	UGT2B15	96	P54855
ITHWTLFNYYNSSGW	TMC2	541	Q8TDI7
WCFTYKGQWKMSYFY	TTC39A	361	Q5SRH9
FRYLEYENFSYWQGW	ZNF214	56	Q9UL59
RWTYSISKNTFWSYF	UGT2B17	96	O75795
IFQSYWGEWNSYYSK	UGT2A2	231	P0DTE5