Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	KLF14 ZNF705A CHD2 ZNF101 ZNF705B GZF1 ZNF555 ZNF700 ZNF548 ZNF423 ZNF436 ZNF705D ZNF440 ZFX ZNF697 ZNF705G ZFP57 ZNF316 YY2	1.14e-12	1459	37	19	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	KLF14 ZNF705A ZNF101 ZNF705B GZF1 ZNF555 ZNF700 ZNF548 ZNF423 ZNF436 ZNF705D ZNF440 ZFX ZNF697 ZNF705G ZFP57 ZNF316 YY2	8.51e-12	1412	37	18	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	KLF14 CHD2 ZNF101 GZF1 ZNF548 ZNF423 ZFX ZNF697 ZNF316 YY2	6.28e-05	1244	37	10	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	KLF14 CHD2 ZNF101 GZF1 ZNF548 ZNF423 ZFX ZNF697 ZNF316 YY2	7.53e-05	1271	37	10	GO:0000987
Domain	Znf_C2H2/integrase_DNA-bd	KLF14 ZNF705A ZNF101 ZNF705B GZF1 ZNF555 ZNF700 ZNF548 ZNF423 ZNF436 ZNF705D ZNF440 ZFX ZNF697 ZNF705G ZFP57 ZNF316 YY2	7.13e-17	694	36	18	IPR013087
Domain	ZINC_FINGER_C2H2_2	KLF14 ZNF705A ZNF101 ZNF705B GZF1 ZNF555 ZNF700 ZNF548 ZNF423 ZNF436 ZNF705D ZNF440 ZFX ZNF697 ZNF705G ZFP57 ZNF316 YY2	4.93e-16	775	36	18	PS50157
Domain	ZINC_FINGER_C2H2_1	KLF14 ZNF705A ZNF101 ZNF705B GZF1 ZNF555 ZNF700 ZNF548 ZNF423 ZNF436 ZNF705D ZNF440 ZFX ZNF697 ZNF705G ZFP57 ZNF316 YY2	5.16e-16	777	36	18	PS00028
Domain	Znf_C2H2-like	KLF14 ZNF705A ZNF101 ZNF705B GZF1 ZNF555 ZNF700 ZNF548 ZNF423 ZNF436 ZNF705D ZNF440 ZFX ZNF697 ZNF705G ZFP57 ZNF316 YY2	7.86e-16	796	36	18	IPR015880
Domain	Znf_C2H2	KLF14 ZNF705A ZNF101 ZNF705B GZF1 ZNF555 ZNF700 ZNF548 ZNF423 ZNF436 ZNF705D ZNF440 ZFX ZNF697 ZNF705G ZFP57 ZNF316 YY2	9.56e-16	805	36	18	IPR007087
Domain	ZnF_C2H2	KLF14 ZNF705A ZNF101 ZNF705B GZF1 ZNF555 ZNF700 ZNF548 ZNF423 ZNF436 ZNF705D ZNF440 ZFX ZNF697 ZNF705G ZFP57 ZNF316 YY2	1.02e-15	808	36	18	SM00355
Domain	-	ZNF705A ZNF101 ZNF705B GZF1 ZNF555 ZNF700 ZNF548 ZNF423 ZNF436 ZNF705D ZNF440 ZFX ZNF697 ZNF705G ZFP57 ZNF316 YY2	1.25e-15	679	36	17	3.30.160.60
Domain	zf-C2H2	KLF14 ZNF705A ZNF101 ZNF705B GZF1 ZNF555 ZNF700 ZNF548 ZNF423 ZNF436 ZNF705D ZNF440 ZFX ZNF697 ZFP57 ZNF316	3.98e-14	693	36	16	PF00096
Domain	KRAB	ZNF705A ZNF101 ZNF705B ZNF555 ZNF700 ZNF548 ZNF436 ZNF705D ZNF440 ZNF705G ZFP57 ZNF316	1.70e-12	358	36	12	PS50805
Domain	KRAB	ZNF705A ZNF101 ZNF705B ZNF555 ZNF700 ZNF548 ZNF436 ZNF705D ZNF440 ZNF705G ZFP57 ZNF316	1.70e-12	358	36	12	PF01352
Domain	KRAB	ZNF705A ZNF101 ZNF705B ZNF555 ZNF700 ZNF548 ZNF436 ZNF705D ZNF440 ZNF705G ZFP57 ZNF316	2.42e-12	369	36	12	SM00349
Domain	KRAB	ZNF705A ZNF101 ZNF705B ZNF555 ZNF700 ZNF548 ZNF436 ZNF705D ZNF440 ZNF705G ZFP57 ZNF316	2.50e-12	370	36	12	IPR001909
Domain	zf-C2H2_6	GZF1 ZNF555 ZNF700 ZNF548 ZNF423 ZNF440 ZNF316	1.95e-06	314	36	7	PF13912
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF705A ZNF101 ZNF555 ZNF700 ZNF548 ZNF436 ZNF705D ZNF440 ZNF697 ZNF705G	9.99e-05	1387	26	10	M734
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF101 ZNF555 ZNF440 ZNF697 ZNF316	1.58e-06	181	38	5	37372979
Pubmed	Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5.	FGF8 GJA5	1.05e-04	14	38	2	23690951
Pubmed	Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40.	FGF8 GJA5	1.96e-04	19	38	2	12435353
Pubmed	Gene-environment interaction impacts on heart development and embryo survival.	FGF8 GJA5	2.65e-04	22	38	2	30787001
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	CHD2 FADS3 GZF1 ZNF436 ZNF697 ZNF316 YY2	2.87e-04	1203	38	7	29180619
Pubmed	Tbx3 is required for outflow tract development.	FGF8 GJA5	3.16e-04	24	38	2	18723448
Pubmed	Positioning of five genes (CASK, ARX, SAT, IMAGE cDNAs 248928 and 253949) from the human X chromosome short arm with respect to evolutionary breakpoints on the mouse X chromosome.	NDP ZFX	3.72e-04	26	38	2	10920247
Pubmed	Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2.	FGF8 GJA5	4.32e-04	28	38	2	15901664
Pubmed	In silico prediction of physical protein interactions and characterization of interactome orphans.	SHC4 SH2D3A YY2	4.46e-04	136	38	3	25402006
Pubmed	Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation.	FGF8 GJA5	5.30e-04	31	38	2	15843414
Pubmed	DNA-binding specificities of human transcription factors.	KLF14 YY2	5.30e-04	31	38	2	23332764
Pubmed	Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.	ZNF101 FADS3	6.38e-04	34	38	2	19060911
Pubmed	Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis.	FGF8 YY2	7.15e-04	36	38	2	32703236
Pubmed	Arid3b is essential for second heart field cell deployment and heart patterning.	FGF8 GJA5	1.02e-03	43	38	2	25336743
Interaction	ZNF667 interactions	ZNF423 ZNF697 ZFP57 YY2	1.65e-06	53	33	4	int:ZNF667
Interaction	ZNF287 interactions	GZF1 ZNF423 ZNF697 ZFP57	2.72e-06	60	33	4	int:ZNF287
Interaction	ZNF710 interactions	GZF1 ZNF423 ZNF697	1.58e-05	30	33	3	int:ZNF710
Interaction	ZNF652 interactions	GZF1 ZNF423 ZNF697	2.53e-05	35	33	3	int:ZNF652
Interaction	ZFP28 interactions	GZF1 ZNF423 ZNF697	2.99e-05	37	33	3	int:ZFP28
Interaction	ZFP37 interactions	GZF1 ZNF423 ZNF697	7.00e-05	49	33	3	int:ZFP37
Interaction	ZBTB20 interactions	GZF1 ZNF423 ZNF697	8.37e-05	52	33	3	int:ZBTB20
Interaction	PRDM4 interactions	GZF1 ZNF423 ZNF697	8.37e-05	52	33	3	int:PRDM4
Interaction	ZNF8 interactions	ZNF423 ZFP57 YY2	2.03e-04	70	33	3	int:ZNF8
Interaction	PRDM5 interactions	GZF1 ZNF423 ZNF697	3.02e-04	80	33	3	int:PRDM5
Interaction	LTBP2 interactions	ZNF101 ZNF555 ZNF316	3.61e-04	85	33	3	int:LTBP2
Cytoband	8p23.1	ZNF705B ZNF705D ZNF705G	2.86e-04	154	38	3	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ZNF101 ZNF555 ZNF700 ZNF440 SH2D3A	4.86e-04	797	38	5	chr19p13
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	ZNF705B ZNF705D ZNF705G	9.67e-04	234	38	3	chr8p23
Cytoband	Ensembl 112 genes in cytogenetic band chrXp22	LINC01546 ZFX YY2	1.17e-03	250	38	3	chrXp22
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	KLF14 ZNF705A ZNF101 ZNF705B GZF1 ZNF555 ZNF700 ZNF548 ZNF423 ZNF436 ZNF705D ZNF440 ZFX ZNF697 ZNF705G ZFP57 ZNF316 YY2	5.95e-17	718	34	18	28
GeneFamily	SH2 domain containing	SHC4 SH2D3A	1.54e-02	101	34	2	741
Disease	myoclonic-atonic epilepsy (implicated_via_orthology)	CHD2 VARS2	2.86e-05	7	35	2	DOID:0060475 (implicated_via_orthology)
Disease	tetralogy of Fallot (implicated_via_orthology)	FGF8 GJA5	1.23e-04	14	35	2	DOID:6419 (implicated_via_orthology)
Disease	sphingolipid measurement	ZNF101 FADS3	1.04e-03	40	35	2	EFO_0004622
Disease	Premature atrial contractions	ZNF700 ZNF440	1.95e-03	55	35	2	HP_0006699
Disease	Amphetamine Abuse	SERPINA5 ZNF423	3.59e-03	75	35	2	C0236807
Disease	Amphetamine Addiction	SERPINA5 ZNF423	3.59e-03	75	35	2	C0236804
Disease	Amphetamine-Related Disorders	SERPINA5 ZNF423	3.59e-03	75	35	2	C0236733
Disease	unipolar depression, bipolar disorder, schizophrenia, sex interaction measurement	SHC4 DNAJC7	3.69e-03	76	35	2	EFO_0003761, EFO_0008343, MONDO_0004985, MONDO_0005090

Protein segments in the cluster

Peptide	Gene	Start	Entry
DYEKHGHRHSMIRRV	BEST3	381	Q8N1M1
HMLIYHKRCHTGERP	GZF1	476	Q9H116
AHDHREDMKGIPFHR	C9orf64	321	Q5T6V5
GHLSPRSYRNMLHEH	KIAA0408	526	Q6ZU52
HQREVHFMKRLPRGH	FGF8	186	P55075
KDHHYGDRRHMDAHR	CHD2	1671	O14647
HRLPHGYHSDKRRLS	GJA5	331	P36382
KGMKYLHHREFVHGR	GUCY2F	656	P51841
GASLHRHHPREMKKR	SERPINA5	16	P05154
YRKRALMHHPDRHSG	DNAJC7	401	Q99615
TKHARRHPTYHPDMI	KLF14	271	Q8TD94
MLVHFYPRRHSHPRA	LINC01546	31	A6NGU7
HHLFPRMPRHNYSRV	FADS3	386	Q9Y5Q0
RYTHLHGRQLRHPLM	VARS2	356	Q5ST30
MVRRKHRPHSGVFHC	TRIM45	496	Q9H8W5
HHHGRGYLRMSPLFK	ABCC6	56	O95255
HPGMLHRAKYSRFRN	SHC4	21	Q6S5L8
SPKRMGVHHLHRKDS	TJAP1	531	Q5JTD0
HSPRSYRRHERIHMG	ZNF440	266	Q8IYI8
SSYHRHERSHMGEKP	ZNF700	291	Q9H0M5
RLRRHKMTHTGERPY	ZNF705A	186	Q6ZN79
LVRHRRAHTGEKPYH	ZNF436	321	Q9C0F3
HLRMHVRTHNGERPY	ZNF555	186	Q8NEP9
PKSLSYHRRMHLGER	ZFP57	131	Q9NU63
LHGARHMVRDAPKFR	SH2D3A	501	Q9BRG2
RDYAAMRKHLHIHGP	YY2	266	O15391
HLRRHKMTHTGERPY	ZNF705G	186	A8MUZ8
PRRCMRHHYVDSISH	NDP	36	Q00604
DKPAHRRFHRLHHPM	ZNF697	156	Q5TEC3
YLRRHKMTHTGERPY	ZNF705B	186	P0CI00
YLRRHKMTHTGERPY	ZNF705D	186	P0CH99
FLDRHMRAHAGHKRS	ZNF101	116	Q8IZC7
LAKHQRYHAGERPHR	ZNF316	706	A6NFI3
SRGFLKRHMKNHPEH	ZFX	436	P17010
YRLMRHKRVHTGERP	ZNF548	266	Q8NEK5
REHLQTHRGPAKHYM	ZNF423	946	Q2M1K9
HGRSSRHRNFPMKKH	TEX46	86	H3BTG2
HRSPMREKGRHDHER	ZC3H13	391	Q5T200
AKTRHERMHTRRPYH	MYO3B	321	Q8WXR4