Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	plus-end-directed microtubule motor activity	KIF1B KIF1C	3.99e-04	17	35	2	GO:0008574
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2D SETBP1	5.56e-04	20	35	2	GO:0042800
GeneOntologyMolecularFunction	poly(A) binding	PABPN1L PABPC1	1.18e-03	29	35	2	GO:0008143
GeneOntologyMolecularFunction	lysine-acetylated histone binding	MLLT1 THAP7	1.26e-03	30	35	2	GO:0070577
GeneOntologyMolecularFunction	acetylation-dependent protein binding	MLLT1 THAP7	1.34e-03	31	35	2	GO:0140033
GeneOntologyMolecularFunction	poly-purine tract binding	PABPN1L PABPC1	1.91e-03	37	35	2	GO:0070717
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	KMT2D SETBP1	2.70e-03	44	35	2	GO:0140938
GeneOntologyBiologicalProcess	retrograde neuronal dense core vesicle transport	KIF1B KIF1C	4.18e-05	6	35	2	GO:1990049
GeneOntologyBiologicalProcess	anterograde neuronal dense core vesicle transport	KIF1B KIF1C	7.78e-05	8	35	2	GO:1990048
HumanPheno	Patent foramen ovale	PIGN STK4 KMT2D ATN1 OCLN	2.01e-05	135	14	5	HP:0001655
Domain	Kinesin_assoc	KIF1B KIF1C	4.80e-05	6	34	2	PF16183
Domain	Kinesin_assoc	KIF1B KIF1C	4.80e-05	6	34	2	IPR032405
Domain	FHA	KIF1B KIF1C	1.18e-03	28	34	2	SM00240
Domain	FHA_DOMAIN	KIF1B KIF1C	1.45e-03	31	34	2	PS50006
Domain	FHA	KIF1B KIF1C	1.45e-03	31	34	2	PF00498
Domain	FHA_dom	KIF1B KIF1C	1.95e-03	36	34	2	IPR000253
Domain	-	KIF1B KIF1C	1.95e-03	36	34	2	2.60.200.20
Domain	Kinesin_motor_CS	KIF1B KIF1C	2.52e-03	41	34	2	IPR019821
Domain	Kinesin-like_fam	KIF1B KIF1C	2.77e-03	43	34	2	IPR027640
Domain	KINESIN_MOTOR_1	KIF1B KIF1C	2.90e-03	44	34	2	PS00411
Domain	-	KIF1B KIF1C	2.90e-03	44	34	2	3.40.850.10
Domain	Kinesin_motor_dom	KIF1B KIF1C	2.90e-03	44	34	2	IPR001752
Domain	Kinesin	KIF1B KIF1C	2.90e-03	44	34	2	PF00225
Domain	KISc	KIF1B KIF1C	2.90e-03	44	34	2	SM00129
Domain	KINESIN_MOTOR_2	KIF1B KIF1C	2.90e-03	44	34	2	PS50067
Domain	SMAD_FHA_domain	KIF1B KIF1C	4.03e-03	52	34	2	IPR008984
Pubmed	In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport.	KIF1B KIF1C	2.95e-06	3	35	2	23404705
Pubmed	The mutational landscape in pediatric acute lymphoblastic leukemia deciphered by whole genome sequencing.	KMT2D KIF1B	2.95e-06	3	35	2	25355294
Pubmed	An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos.	PABPN1L PABPC1	5.90e-06	4	35	2	15630085
Pubmed	MLL associates specifically with a subset of transcriptionally active target genes.	MLLT1 KMT2D	1.47e-05	6	35	2	16199523
Pubmed	Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation.	CRKL THAP7	2.74e-05	8	35	2	25658046
Pubmed	HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.	KIF1B KIF1C	2.74e-05	8	35	2	25818806
Pubmed	Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator.	WIZ PALLD EZHIP	3.56e-05	63	35	3	25680957
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	STK4 WIZ MAST2 PABPC1	8.59e-05	232	35	4	25515538
Pubmed	A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.	MAST2 KIF1B KIF1C	9.34e-05	87	35	3	17979178
Pubmed	Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor.	PRKAG2 THAP7 KIF1C	1.10e-04	92	35	3	20368287
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	STK4 MAST2 PABPC1 PALLD KIF1B KIF1C	1.99e-04	861	35	6	36931259
Pubmed	Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes.	ATN1 PABPC1	2.46e-04	23	35	2	20696395
Pubmed	Risk of meningomyelocele mediated by the common 22q11.2 deletion.	CRKL THAP7	2.91e-04	25	35	2	38696583
Pubmed	Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.	KIF1B KIF1C	2.91e-04	25	35	2	9275178
Pubmed	ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.	OCLN PALLD	3.40e-04	27	35	2	17525332
Pubmed	The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing.	ATN1 THAP7	3.93e-04	29	35	2	17577209
Pubmed	Interaction network of human early embryonic transcription factors.	KMT2D RAD54L2 WIZ ATN1	4.17e-04	351	35	4	38297188
Pubmed	The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.	AKAP10 CRKL	4.20e-04	30	35	2	30480076
Pubmed	All kinesin superfamily protein, KIF, genes in mouse and human.	KIF1B KIF1C	6.41e-04	37	35	2	11416179
Pubmed	An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.	PALLD CREB3L1	6.41e-04	37	35	2	21362171
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	OCLN PABPC1 PALLD CRKL KIF1B	6.75e-04	708	35	5	39231216
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MLLT1 KMT2D SLC2A4RG WIZ RALGAPA2 MAST2	7.48e-04	1105	35	6	35748872
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	RAD54L2 ATN1 PABPC1 SETBP1	8.91e-04	430	35	4	35044719
Pubmed	Identification of APBB1 as a substrate for anaplastic lymphoma kinase.	PALLD CRKL	9.06e-04	44	35	2	39115278
Pubmed	Congenital Diaphragmatic Hernia Overview	PIGN KMT2D	9.90e-04	46	35	2	20301533
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	RNASEK SPEM2 KIF1C	2.32e-03	346	35	3	chr17p13
Cytoband	17p13.1	RNASEK SPEM2	3.69e-03	118	35	2	17p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	PCED1B COQ10A KMT2D	4.08e-03	423	35	3	chr12q13
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF1B KIF1C	8.41e-04	46	17	2	622
GeneFamily	RNA binding motif containing	PABPN1L PABPC1	1.67e-02	213	17	2	725
Coexpression	GSE27859_MACROPHAGE_VS_DC_DN	KMT2D WIZ ATN1 KIF1B AGPAT4	6.01e-06	196	35	5	M8588
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-IPC_like\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	CREG2 HUNK UBE2QL1 SETBP1	6.70e-06	156	35	4	7e6805ebc7bc2f9c5965321d16922c155719970f
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-IPC_like-IPs_and_early_cortical_neurons\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	CREG2 HUNK UBE2QL1 SETBP1	6.70e-06	156	35	4	741de05295b2d012ac8576378f37709a97c8fb50
ToppCell	T_cells-GNLY+GZMB+_T_cells\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	CREG2 PALLD SETBP1 AGPAT4	9.62e-06	171	35	4	04c811817cfec45af5f2891793106cc7ddb0300e
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATN1 PABPC1 PALLD KIF1C	1.43e-05	189	35	4	965e0e388251e7318f8b463816dc96ccb4658677
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	UBE2QL1 PRKAG2 MAST2 PALLD	1.43e-05	189	35	4	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	ILEUM-non-inflamed-(7)_Endothelial_cell-(7)_ACKR1+_endothelial_cells\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PRKAG2 OCLN RALGAPA2 PALLD	1.68e-05	197	35	4	143607d195c8aa2b94d995af0b2ef38582565611
Disease	Microphthalmos	BEST1 KMT2D	6.23e-05	11	32	2	C0026010
Disease	nervous system disease (implicated_via_orthology)	KIF1B KIF1C	7.47e-05	12	32	2	DOID:863 (implicated_via_orthology)
Disease	colon carcinoma (is_marker_for)	KMT2D CRKL	8.82e-05	13	32	2	DOID:1520 (is_marker_for)
Disease	Hereditary Paraganglioma-Pheochromocytoma Syndrome	KMT2D KIF1B	2.84e-04	23	32	2	C1708353
Disease	phosphatidylcholine 38:5 measurement	BEST1 PABPC1	5.89e-04	33	32	2	EFO_0010387
Disease	hepatocyte growth factor-like protein measurement	STK4 RAD54L2	7.82e-04	38	32	2	EFO_0008154

Protein segments in the cluster

Peptide	Gene	Start	Entry
MWPFPSRSLFPPPTQ	PABPN1L	1	A6NDY0
FFSRGPQPRPSSPMS	PRKAG2	76	Q9UGJ0
SPRSLPPSSPVRPMA	CREB3L1	221	Q96BA8
SPRTLRPDPGPAMSF	AKAP10	11	O43572
PASSSAPAPPMRFPY	ATN1	361	P54259
PLSPTPMFFPLEPSA	BEST1	471	O76090
LSEPRMFAPFPSPVL	RAD54L2	1391	Q9Y4B4
AARARPPPAPPGMFS	CREG2	91	Q8IUH2
MSSRPLESPPPYRPD	OCLN	1	Q16625
PAAPRPPFSTMRPAS	PABPC1	456	P11940
CRRFFPPPMPLSKPV	KIF1B	1216	O60333
MRASSPSPPGRFFLP	EZHIP	406	Q86X51
GQKSPRFRMPPTSRP	FAM90A27P	401	A6NNH2
MPFFPTPRYQRPAPV	PCED1B	381	Q96HM7
DRMPSARPPSPPLSS	KIF1C	906	O43896
TTLIEPAPRYPSPPM	CRKL	96	P46109
SPSPPVLIPPLRMFA	RALGAPA2	981	Q2PPJ7
LPSPMSPTPRQFGRA	PALLD	761	Q8WX93
GPLPPPRPMRFLTSC	COQ10A	36	Q96MF6
SSMEFIPVPPPRTPR	HUNK	516	P57058
PFPSRDPRSLGPMVP	MAST2	1546	Q6P0Q8
SPPMTFSPALPPLRS	HCFC1R1	81	Q9NWW0
VSRPSPDYPMLPTIP	MLLT1	151	Q03111
SPTASPPPTARKMFP	WIZ	1151	O95785
PSPLEPRPVSPSAYM	THAP7	201	Q9BT49
PRPVSPSAYMLRLPP	THAP7	206	Q9BT49
EPGMFPPTPLSPARF	ARL6IP6	181	Q8N6S5
NFPFSPPFMRVLSPR	UBE2QL1	61	A1L167
ADPAPPPTMFVPLSR	SPEM2	436	Q0P670
TPVSPTASMPPAFPR	SLC2A4RG	261	Q9NR83
GMTPQFTPLPPPARR	PIGN	31	O95427
RAIFMIPTNPPPTFR	STK4	231	Q13043
TGTFPETPMVPPRRP	AGPAT4	291	Q9NRZ5
PSPLAPRRSPTPFFM	RNASEK	26	Q6P5S7
AASPFMRPTVPPPQF	SETBP1	1081	Q9Y6X0
RLSRPPPPATPSSMD	KMT2D	2771	O14686