Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionrRNA (cytosine-N4-)-methyltransferase activity

METTL15P1 METTL15

1.47e-052772GO:0071424
GeneOntologyMolecularFunctionamino acid:sodium symporter activity

SLC6A18 SLC1A2 SLC6A14

9.24e-0523773GO:0005283
GeneOntologyMolecularFunctionamino acid:monoatomic cation symporter activity

SLC6A18 SLC1A2 SLC6A14

1.87e-0429773GO:0005416
GeneOntologyMolecularFunctionrRNA (cytosine) methyltransferase activity

METTL15P1 METTL15

2.18e-046772GO:0016434
GeneOntologyMolecularFunctionneutral L-amino acid transmembrane transporter activity

SLC6A18 SLC1A2 SLC6A14

5.29e-0441773GO:0015175
GeneOntologyBiologicalProcessolfactory nerve formation

PLXNA3 PLXNA1

1.38e-052772GO:0021628
GeneOntologyBiologicalProcessolfactory nerve morphogenesis

PLXNA3 PLXNA1

4.12e-053772GO:0021627
HumanPhenoAbnormal circulating C-peptide concentration

ABCC8 INSR PAX4 CNOT1

2.03e-0527324HP:0030794
DomainTyr_kinase_rcpt_2_CS

DDR1 NTRK3 INSR

1.04e-0511763IPR002011
DomainRECEPTOR_TYR_KIN_II

DDR1 NTRK3 INSR

1.39e-0512763PS00239
DomainL_dom-like

NTRK3 INSR DMAC2L ADGRA2 RABGGTA AMIGO1 LRIT1

3.74e-04328767IPR032675
DomainCys-rich_flank_reg_C

NTRK3 ADGRA2 AMIGO1 LRIT1

4.96e-0490764IPR000483
DomainLRRCT

NTRK3 ADGRA2 AMIGO1 LRIT1

4.96e-0490764SM00082
DomainLDLR_class-A_CS

LRP2 CFI LRP1B

5.74e-0440763IPR023415
DomainPlexin_cytopl

PLXNA3 PLXNA1

5.77e-049762PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNA3 PLXNA1

5.77e-049762IPR013548
DomainPlexin

PLXNA3 PLXNA1

5.77e-049762IPR031148
DomainEMI

COL26A1 MMRN2

7.20e-0410762PF07546
DomainLdl_recept_a

LRP2 CFI LRP1B

8.13e-0445763PF00057
Domain-

LRP2 CFI LRP1B

8.67e-04467634.10.400.10
DomainLDLRA_1

LRP2 CFI LRP1B

9.82e-0448763PS01209
DomainLDLRA_2

LRP2 CFI LRP1B

1.04e-0349763PS50068
DomainLDrepeatLR_classA_rpt

LRP2 CFI LRP1B

1.04e-0349763IPR002172
DomainLDLa

LRP2 CFI LRP1B

1.04e-0349763SM00192
DomainOxysterol-bd

OSBPL5 OSBPL6

1.05e-0312762IPR000648
DomainOxysterol-bd_CS

OSBPL5 OSBPL6

1.05e-0312762IPR018494
DomainOxysterol_BP

OSBPL5 OSBPL6

1.05e-0312762PF01237
DomainOSBP

OSBPL5 OSBPL6

1.05e-0312762PS01013
Domain-

PLA2R1 MRC2

1.24e-03137622.10.10.10
DomainLRR

NTRK3 ADGRA2 RABGGTA AMIGO1 LRIT1

1.37e-03201765PS51450
DomainFN_type2_col-bd

PLA2R1 MRC2

1.44e-0314762IPR000562
DomainFN2_2

PLA2R1 MRC2

1.44e-0314762PS51092
DomainLdl_recept_b

LRP2 LRP1B

1.44e-0314762PF00058
DomainLDLRB

LRP2 LRP1B

1.44e-0314762PS51120
Domainfn2

PLA2R1 MRC2

1.44e-0314762PF00040
DomainFN2_1

PLA2R1 MRC2

1.44e-0314762PS00023
DomainFN2

PLA2R1 MRC2

1.44e-0314762SM00059
Domain-

PAPPA2 PLXNA3 ICOS NTRK3 INSR ADGRA2 PLXNA1 AMIGO1 LRIT1

1.45e-036637692.60.40.10
DomainLY

LRP2 LRP1B

1.66e-0315762SM00135
DomainLDLR_classB_rpt

LRP2 LRP1B

1.66e-0315762IPR000033
DomainEGF_extracell

NTNG2 LRP2 LRP1B

1.88e-0360763IPR013111
DomainEGF_2

NTNG2 LRP2 LRP1B

1.88e-0360763PF07974
DomainEMI_domain

COL26A1 MMRN2

1.89e-0316762IPR011489
DomainLaminin_N

NTNG2 LAMA3

1.89e-0316762IPR008211
DomainLAMININ_NTER

NTNG2 LAMA3

1.89e-0316762PS51117
DomainLaminin_N

NTNG2 LAMA3

1.89e-0316762PF00055
DomainLamNT

NTNG2 LAMA3

1.89e-0316762SM00136
Domain-

NTRK3 DMAC2L ADGRA2 RABGGTA AMIGO1 LRIT1

1.96e-033217663.80.10.10
DomainLRR_1

NTRK3 ADGRA2 RABGGTA AMIGO1 LRIT1

1.99e-03219765PF00560
Domain-

IPO7 PRKDC HEATR5B CFAP69 STAG3

2.11e-032227651.25.10.10
DomainEMI

COL26A1 MMRN2

2.14e-0317762PS51041
DomainIg-like_fold

PAPPA2 PLXNA3 ICOS NTRK3 INSR ADGRA2 PLXNA1 AMIGO1 LRIT1

2.22e-03706769IPR013783
Domain-

PLXNA3 WDR97 SMU1 PLXNA1 DMXL1 WDR72

2.36e-033337662.130.10.10
DomainNA_NEUROTRAN_SYMP_2

SLC6A18 SLC6A14

2.40e-0318762PS00754
DomainWD40/YVTN_repeat-like_dom

PLXNA3 WDR97 SMU1 PLXNA1 DMXL1 WDR72

2.43e-03335766IPR015943
DomainSNF

SLC6A18 SLC6A14

2.67e-0319762PF00209
DomainNA_NEUROTRAN_SYMP_1

SLC6A18 SLC6A14

2.67e-0319762PS00610
DomainNA_NEUROTRAN_SYMP_3

SLC6A18 SLC6A14

2.67e-0319762PS50267
DomainNa/ntran_symport

SLC6A18 SLC6A14

2.67e-0319762IPR000175
DomainEGF-like_dom

NTNG2 LRP2 LAMA3 LRP1B GP2

3.46e-03249765IPR000742
DomainGrowth_fac_rcpt_

INSR LRP2 LAMA3 LRP1B

3.77e-03156764IPR009030
DomainEGF_1

NTNG2 LRP2 LAMA3 LRP1B GP2

3.83e-03255765PS00022
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

DDR1 PLA2R1 NTRK3 INSR LRP2 LRP1B

1.30e-0710180623382219
Pubmed

Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.

NTRK3 ADGRA2 AMIGO1 LRIT1

1.14e-063480418848646
Pubmed

Progranulin is required for proper ER stress response and inhibits ER stress-mediated apoptosis through TNFR2.

GRN TNFRSF1B

5.23e-06280224703938
Pubmed

Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4⁺ Foxp3⁺ regulatory T cells.

GRN TNFRSF1B

5.23e-06280224383743
Pubmed

Association between vitamin D status and age-related macular degeneration by genetic risk.

CFH CFI

5.23e-06280226312598
Pubmed

Four Single Nucleotide Polymorphisms in INSR, SLC6A14, TAS2R38, and OR2W3 Genes in Association with Idiopathic Infertility in Persian Men.

INSR SLC6A14

5.23e-06280227172637
Pubmed

METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue.

METTL15P1 METTL15

5.23e-06280232573735
Pubmed

Regulatory components of the alternative complement pathway in endothelial cell cytoplasm, factor H and factor I, are not packaged in Weibel-Palade bodies.

CFH CFI

5.23e-06280225803806
Pubmed

Use of time-resolved FRET to validate crystal structure of complement regulatory complex between C3b and factor H (N terminus).

CFH CFI

5.23e-06280221936007
Pubmed

Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice.

METTL15P1 METTL15

5.23e-06280235682734
Pubmed

Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer.

SLC1A2 SLC6A14

5.23e-06280231269432
Pubmed

Discoidin domain receptor 1 modulates insulin receptor signaling and biological responses in breast cancer cells.

DDR1 INSR

5.23e-06280228591735
Pubmed

PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.

FZD7 PLXNA3 NTNG2 PLXNA1 LRIT1

7.77e-0611780517145500
Pubmed

Semi-automatic classification of skeletal morphology in genetically altered mice using flat-panel volume computed tomography.

DDR1 PRKDC

1.57e-05380217658952
Pubmed

Identification of plexin family molecules in mice.

PLXNA3 PLXNA1

1.57e-0538028806646
Pubmed

Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis.

ICOS PRKDC

1.57e-05380212960306
Pubmed

Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome.

CFH CFI

1.57e-05380216621965
Pubmed

Insights into hemolytic uremic syndrome: segregation of three independent predisposition factors in a large, multiple affected pedigree.

CFH CFI

1.57e-05380216386793
Pubmed

Ultrastructures and interactions of complement factors H and I.

CFH CFI

1.57e-0538021401896
Pubmed

The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.

GRN TNFRSF1B

1.57e-05380221393509
Pubmed

Differential expression of plexin-A subfamily members in the mouse nervous system.

PLXNA3 PLXNA1

1.57e-05380211241833
Pubmed

Immunodeficient and immunosuppressed mice as models to test anti-Pneumocystis carinii drugs.

PAX4 PRKDC

1.57e-0538029021175
Pubmed

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.

CFH CFI

1.57e-05380228671664
Pubmed

Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome.

CFH CFI

1.57e-05380217599974
Pubmed

A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative CFI variants in age-related macular degeneration.

CFH CFI

1.57e-05380236643920
Pubmed

Genotype-phenotype correlations of low-frequency variants in the complement system in renal disease and age-related macular degeneration.

CFH CFI

1.57e-05380229888403
Pubmed

Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia.

CFH CFI

1.57e-05380222514678
Pubmed

Interactions between human complement components factor H, factor I and C3b.

CFH CFI

1.57e-0538029291131
Pubmed

Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice.

CFH CFI

1.57e-05380218202746
Pubmed

Factor H, membrane cofactor protein, and factor I mutations in patients with hemolysis, elevated liver enzymes, and low platelet count syndrome.

CFH CFI

1.57e-05380218658028
Pubmed

Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner.

PLXNA3 PLXNA1

1.57e-05380220138877
Pubmed

Lack of Evidence for a Direct Interaction of Progranulin and Tumor Necrosis Factor Receptor-1 and Tumor Necrosis Factor Receptor-2 From Cellular Binding Studies.

GRN TNFRSF1B

1.57e-05380229740434
Pubmed

Dual roles of different redox forms of complement factor H in protecting against age related macular degeneration.

CFH CFI

1.57e-05380230253188
Pubmed

New loci associated with kidney function and chronic kidney disease.

UBE2Q2 AMIGO1 GP2 WDR72

1.68e-056680420383146
Pubmed

The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.

PLXNA3 NTNG2 INSR

2.60e-052580335874829
Pubmed

Genetic disorders in complement (regulating) genes in patients with atypical haemolytic uraemic syndrome (aHUS).

CFH CFI

3.13e-05480220106822
Pubmed

Dependence receptors: the trophic theory revisited.

NTRK3 INSR

3.13e-05480221139137
Pubmed

Delays and diversions mark the development of B cell responses to Borrelia burgdorferi infection.

ICOS PRKDC

3.13e-05480222547698
Pubmed

New functional and structural insights from updated mutational databases for complement factor H, Factor I, membrane cofactor protein and C3.

CFH CFI

3.13e-05480225188723
Pubmed

Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster.

PLXNA3 PLXNA1

3.13e-05480211306810
Pubmed

PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.

PLXNA3 PLXNA1

3.13e-05480225518740
Pubmed

Inhibition of c3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components.

CFH CFI

3.13e-05480224983375
Pubmed

Rare Genetic Variants Associated With Development of Age-Related Macular Degeneration.

CFH CFI

3.13e-05480226767664
Pubmed

Determination of cell adhesion sites of neuropilin-1.

PLXNA3 PLXNA1

3.13e-05480210725340
Pubmed

Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study.

ABCC8 INSR

3.13e-05480237052755
Pubmed

A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.

PLXNA3 PLXNA1

3.13e-0548028570614
Pubmed

Seven new loci associated with age-related macular degeneration.

CFH DDR1 CFI

4.10e-052980323455636
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

PLXNA3 EHMT2 INSR CPNE3 LRP2 LRP1B PLXNA1 UBE2Q2 DMXL1

4.62e-0573080934857952
Pubmed

C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity.

GPR6 LRP1B

5.20e-05580223150673
Pubmed

Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.

PLXNA3 PLXNA1

5.20e-05580225313870
Pubmed

PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner.

GRN TNFRSF1B

5.20e-05580225387791
Pubmed

Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains.

GRN TNFRSF1B

5.20e-05580224070898
Pubmed

Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection.

PRKDC TNFRSF1B

5.20e-0558029144497
Pubmed

The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis.

PRKDC TNFRSF1B

5.20e-05580212133972
Pubmed

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.

FZD7 NTNG2 NTRK3 PLXNA1

5.96e-059180428558017
Pubmed

Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism.

OSBPL5 OSBPL6

7.79e-05680210588946
Pubmed

Overlapping, complementary and site-specific expression pattern of genes of the EMILIN/Multimerin family.

COL26A1 MMRN2

7.79e-05680214996434
Pubmed

The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.

ICOS PRKDC

7.79e-05680216081804
Pubmed

M-CSF mediates TNF-induced inflammatory osteolysis.

PRKDC TNFRSF1B

7.79e-05680216294221
Pubmed

Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer.

RBL2 PRKDC

7.79e-05680227373157
Pubmed

A cellular repressor of E1A-stimulated genes that inhibits activation by E2F.

PAPPA2 RBL2

7.79e-0568029710587
Pubmed

Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.

RBL2 PRKDC

7.79e-05680221875955
Pubmed

Plk4 is required for cytokinesis and maintenance of chromosomal stability.

PRKDC RTKN

7.79e-05680220348415
Pubmed

Atypical postinfectious glomerulonephritis is associated with abnormalities in the alternative pathway of complement.

CFH CFI

7.79e-05680223235567
Pubmed

NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB.

PRKDC TNFRSF1B

7.79e-05680224892805
Pubmed

Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.

PLXNA3 PLXNA1

7.79e-05680219480842
Pubmed

An essential role for Polycomb Repressive Complex 2 in the mouse ovary.

EHMT2 INSR SUZ12 ZFPM2

7.95e-059880435084365
Pubmed

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

DDR1 NTRK3 INSR

1.09e-044080330898150
Pubmed

Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.

PLXNA3 PLXNA1

1.09e-04780219063725
Pubmed

Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.

PLXNA3 PLXNA1

1.09e-04780219655386
Pubmed

Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer.

RBL2 PRKDC

1.09e-04780238788720
Pubmed

Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.

PLXNA3 PLXNA1

1.09e-04780210520994
Pubmed

Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome.

CFH CFI

1.09e-04780220513133
Pubmed

Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome.

CFH CFI

1.09e-04780219861685
Pubmed

Developmental expression and biochemical characterization of Emu family members.

COL26A1 MMRN2

1.09e-04780212221002
Pubmed

The expression of plexins during mouse embryogenesis.

PLXNA3 PLXNA1

1.45e-04880215661641
Pubmed

Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration.

CFH CFI

1.45e-04880220888482
Pubmed

C3 Glomerulopathy

CFH CFI

1.45e-04880220301598
Pubmed

Integration of opposing semaphorin guidance cues in cortical axons.

PLXNA3 PLXNA1

1.45e-04880222368082
Pubmed

TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6.

PLXNA3 NTRK3 PLXNA1

1.77e-044780335462405
Pubmed

PlexinA2 and semaphorin signaling during cardiac neural crest development.

PLXNA3 PLXNA1

1.86e-04980211688557
Pubmed

The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.

NTRK3 INSR

1.86e-04980212237455
Pubmed

Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis.

PLOD3 EHMT2

1.86e-04980226028330
Pubmed

Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection.

PRKDC TNFRSF1B

1.86e-04980215153508
Pubmed

Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome.

CFH CFI

1.86e-04980220059470
Pubmed

The role of neuropilins in cell signalling.

PLXNA3 PLXNA1

1.86e-04980219909241
Pubmed

G9a histone methyltransferase contributes to imprinting in the mouse placenta.

EHMT2 OSBPL5

1.86e-04980218039842
Pubmed

Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development.

PLXNA3 PLXNA1

2.32e-041080218804103
Pubmed

ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency.

EHMT2 SUZ12

2.32e-041080220569692
Pubmed

Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: linkage of candidate genes using two sib-pair based variance components analyses.

ABCC8 INSR

2.32e-041080218828733
Pubmed

Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.

CFH CFI

2.32e-041080222705344
Pubmed

Establishment and Dysfunction of the Blood-Brain Barrier.

INSR LRP2 SLC1A2

2.39e-045280326590417
Pubmed

Semaphorin-5B Controls Spiral Ganglion Neuron Branch Refinement during Development.

PLXNA3 PLXNA1

2.84e-041180231209173
Pubmed

The OSBP-related protein family in humans.

OSBPL5 OSBPL6

2.84e-041180211483621
Pubmed

Genetic Atypical Hemolytic-Uremic Syndrome

CFH CFI

2.84e-041180220301541
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP2 LRP1B

2.84e-041180224639464
Pubmed

Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development.

METTL15P1 METTL15

2.84e-041180233627187
Pubmed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.

PLXNA3 NTRK3 INSR ZFHX2 PLXNA1

2.91e-0425180529031500
Pubmed

Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.

PLXNA3 PLXNA1

3.40e-041280225839327
Pubmed

PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons.

PLXNA3 PLXNA1

3.40e-041280231690636
InteractionFBXO2 interactions

PLXNA3 PLOD3 MRC2 INSR LRP2 LAMA3 GRN PAX4 LRP1B PLXNA1 CHST8

2.93e-074117411int:FBXO2
InteractionIGFL3 interactions

INSR LRP2 LAMA3 GRN LRP1B

8.22e-0675745int:IGFL3
InteractionTAFA3 interactions

MRC2 INSR LRP2 GRN LRP1B

9.97e-0678745int:TAFA3
InteractionPTPRK interactions

PLXNA3 INSR LAMA3 LRP1B PLXNA1 AMIGO1

4.76e-05177746int:PTPRK
InteractionTAFA4 interactions

MRC2 INSR LRP2 PLXNA1

4.96e-0555744int:TAFA4
GeneFamilyEMI domain containing

COL26A1 MMRN2

2.10e-047582540
GeneFamilyReceptor Tyrosine Kinases|CD molecules

DDR1 NTRK3 INSR

2.85e-0440583321
GeneFamilyPlexins

PLXNA3 PLXNA1

3.59e-049582683
GeneFamilyOxysterol binding proteins|Pleckstrin homology domain containing

OSBPL5 OSBPL6

6.54e-0412582670
GeneFamilyLow density lipoprotein receptors

LRP2 LRP1B

7.71e-0413582634
GeneFamilyComplement system|Sushi domain containing

CFH CFI

5.94e-0336582492
GeneFamilyADAM metallopeptidase domain containing|CD molecules

DDR1 ICOS MRC2 INSR TNFRSF1B

8.53e-03394585471
GeneFamilyWD repeat domain containing

WDR97 SMU1 DMXL1 WDR72

9.91e-03262584362
GeneFamilyC-type lectin domain family

PLA2R1 MRC2

9.97e-0347582494
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA3 ZGLP1 ITFG2 CENPI LRP1B AMIGO1 LRIT1

1.99e-081658070edd56e8d14eaeced9882dd9206ea93e8f402e8d
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA3 ZGLP1 ITFG2 CENPI LRP1B AMIGO1 LRIT1

1.99e-08165807fa3aadfff6fb1e7f142db333c60c2cba02b17e6c
ToppCellP15-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DDR1 RNF181 OSBPL6 LAMA3 SLC6A14 CHST8

1.07e-06186806521e6e007bbae73e7328153aa170cf04ca3c1093
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PAPPA2 COL26A1 NTRK3 TECRL CFI LRP1B

1.25e-06191806156b467187331ac6ca390d6ca861d9670bb7b956
ToppCellASK452-Epithelial-Transformed_epithelium|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

CFH MRC2 CPNE3 LRP2 CFI SLC6A14

1.50e-06197806b22a79a5922c865a360e2afc5506a08a512fa76a
ToppCellfacs-Lung-nan-3m-Epithelial-type_I_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JADE3 OSBPL6 LAMA3 PRKDC SLC6A14

1.24e-0516680511b0ae82b3068ef91715dbdd49fe8e9791b4a480
ToppCellfacs-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JADE3 OSBPL6 LAMA3 PRKDC SLC6A14

1.24e-05166805fcc1aec31ebd39432d4cb284dc8fadf34e3c566a
ToppCell5'-Adult-LargeIntestine-Mesenchymal-stromal_related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH FZD7 FAM180B ADGRA2 ZFPM2

1.60e-05175805b8995e7ada85ba959f06264a0295b61e390c4e6c
ToppCell5'-Adult-LargeIntestine-Mesenchymal-stromal_related-T_reticular|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH FZD7 FAM180B ADGRA2 ZFPM2

1.60e-051758057ae76bd3b4f610b2f98716a4456437cd3696b686
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH MMRN2 ZFHX2 CFI ADGRA2

1.98e-05183805b0b5a41f1a40f9c946d0dc8b67eaccdd9f9b73a5
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ADAMTS19 PLA2R1 NTRK3 CFI ZFPM2

2.37e-051908054f775ee24b14733f06ae40b45f2dc1a0f0df0705
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CFH ADAMTS19 MRC2 NTRK3 ZFPM2

2.49e-051928058d56e360ebc624ca4cd7f0af4f3cc599c244f134
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH MRC2 NTRK3 ADGRA2 ZFPM2

2.49e-05192805d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCellHippocampus-Endothelial|Hippocampus / BrainAtlas - Mouse McCarroll V32

CFH PLA2R1 ITPRIPL2 MRC2 ADGRA2

2.49e-0519280536deadab892d3e639a71f33697bb2d3cbbaa5372
ToppCellMesenchymal-matrix_fibroblast_2_cell|World / Lineage, Cell type, age group and donor

CFH ADAMTS19 MRC2 NTRK3 ZFPM2

2.49e-05192805a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH INSR MMRN2 LAMA3 TNFRSF1B

2.68e-051958056bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCellPCW_10-12-Epithelial-Epithelial_proliferating|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

LRP2 LAMA3 CFI SLC1A2 WDR72

2.68e-05195805ce1ba5911e8a6ddb07434acc37147c38e94245ff
ToppCellfacs-Thymus-Epithelium-24m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 ABCC8 MMRN2 LAMA3 GP2

2.68e-05195805cc89261bb091ef978bd73cffc68ccdd00a8786d1
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH MRC2 NTRK3 ADGRA2 ZFPM2

2.68e-05195805edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCellNS-moderate-d_16-33-Epithelial-Secretory|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CFH DDR1 PLA2R1 INSR SLC6A14

2.75e-0519680570384c1da9baed843f414cfd1403ddd586a2db07
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CFH INSR MMRN2 CFI ADGRA2

2.75e-05196805889c9fed857f64664ca1f47fcec9fecb15ed103c
ToppCell(5)_Fibroblasts-(5)_Fibroblast-E|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

CFH FAM180B MRC2 GRN CFI

2.82e-051978059b1c1d72c5a8c90d71ae31e4c198d2276872eaa0
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

EFCAB12 OSBPL6 ZFHX2 CFAP69 DNAH9

2.82e-0519780574a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH MRC2 NTRK3 ADGRA2 ZFPM2

2.89e-0519880579576525a10ed3e3a9d1608077cd16ecda23376f
ToppCellParenchymal-10x3prime_v2-Stromal-Mesofibroblastic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CFH FZD7 MRC2 NTRK3 ZFPM2

2.89e-051988050cd930e374c2c48d1991b51c025f9801b22ecee7
ToppCellParenchymal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CFH FZD7 MRC2 NTRK3 ZFPM2

2.89e-05198805e0df6d6ff2a9c41d813f84a2a5ee7cb5f6fc3e30
ToppCellKidney|World / Skin and Kidney Cells in Lupus Nephritis Patients.

PAPPA2 LRP2 CFI GP2 WDR72

3.03e-052008051f99afa1f3c32a2a9cfb4ad33ff4d404e34fac63
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Parm1|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PAPPA2 TRPC7 DNAH9 CHST8

4.80e-051118041847dde68d349114286bc3317be6339666df4aa2
ToppCellControl-CD4+_T_activated|Control / Disease condition and Cell class

PAPPA2 PLA2R1 JADE3 MRC2

5.70e-05116804e3d1a90a229f5697b2b715574bb96790a435f73b
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZGLP1 WDR97 CENPI ZFPM2

1.46e-04148804065177aaa63c0441d312260b43ecdac78c84ad03
ToppCellPND01-03-samps-Epithelial-Alveolar_epithelial-AT1_-_meso|PND01-03-samps / Age Group, Lineage, Cell class and subclass

DDR1 OSBPL5 LAMA3 SLC6A14

1.54e-041508046a13e4c4b9c9e54a5016573a37132465ec1c8f99
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LINC00473 TRPC7 LRP2 WDR72

1.58e-04151804f4f7156b2c0cfc78fd1841e07c9915d97ced561f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FZD7 ABCC8 NTRK3 CHST8

1.62e-04152804bd1f36b436d8ab7dd8420f595b97d851eab31a38
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FZD7 ABCC8 NTRK3 CHST8

1.62e-04152804ee329249a034a969a16b26a224aa04249d67382d
ToppCellTCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue-Thryoid_normal_tissue-3|TCGA-Thryoid / Sample_Type by Project: Shred V9

PLA2R1 FAM180B LRP1B ZFPM2

1.71e-041548044e9203c220a44c70cd7979796a0b461991422257
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTS19 PLA2R1 PEDS1

1.75e-0415580490e629681a72baacc7981b82883866a487638dbc
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(NPW+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR6 TRPC7 PAX4 CHST8

1.75e-04155804498e52e2364ff44d3c0c707ba22468217031f5bd
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 FBXO24 SLC6A14 LRIT1

1.84e-041578047fdc0094dd5729990a91a30c1982a14c74650b52
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-microglial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 FBXO24 SLC6A14 LRIT1

1.84e-04157804c762b03e254c73222094725ca8ac1c8eb428bccb
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 FBXO24 SLC6A14 LRIT1

1.84e-041578046b5b08bb5520fcf6f4c0560f7ed7645ec179806d
ToppCellTCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue-Thryoid_normal_tissue|TCGA-Thryoid / Sample_Type by Project: Shred V9

PLA2R1 FAM180B LRP1B ZFPM2

1.88e-041588048e48952af0831a1fc71ad422e8216b5a92a75991
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH LRP2 LAMA3 ZFPM2

1.88e-04158804e7db0ee4740e3c7a4d97d7cd7462e2c2ab458a4b
ToppCellTCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue|TCGA-Thryoid / Sample_Type by Project: Shred V9

PLA2R1 FAM180B LRP1B ZFPM2

1.88e-04158804e5b55c15a8c99c8d7fc94949f0d3c22e0c3fee7b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH LRP2 LAMA3 ZFPM2

1.88e-04158804d39e020c3e77eb9d3de600a171d22f94357061d4
ToppCellTCGA-Thryoid-Solid_Tissue_Normal|TCGA-Thryoid / Sample_Type by Project: Shred V9

PLA2R1 FAM180B LRP1B ZFPM2

1.88e-0415880455214d674808584e4d48f8c5e3b8c0e206cb9bb8
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 NTRK3 STAG3 ZFPM2

1.93e-04159804cfb4a8c8aac34b1a857956d98382d487abcf5444
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 NTRK3 STAG3 ZFPM2

1.93e-04159804a75ab494959575143cefdaec99e7aee3f318d559
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS19 LRP2 LRP1B DNAH9

1.97e-04160804c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS19 LRP2 LRP1B DNAH9

1.97e-0416080425c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell10x5'-bone_marrow-Myeloid_Dendritic-DC1|bone_marrow / Manually curated celltypes from each tissue

MRC2 CPNE3 GRN CFI

2.02e-041618042f068ee643de2f647c289779a6624265ab9a749b
ToppCell5'-Adult-SmallIntestine-Epithelial-neuro-epithelial-EECs|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

WDR97 ABCC8 PAX4 PMFBP1

2.07e-04162804478cf560ef33c5c324142c76417447d4a571a2c9
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

CFH CFI SLC6A14 AMIGO1

2.07e-041628042259e9536147e9cdee772e3a30ba7d104573262c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 FAM180B LAMA3 LRP1B

2.07e-04162804373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FBXO24 ICOS MRC2 DNAH9

2.17e-04164804d8ecb3de6e34f5f574449e3d2f26fa0b2b7e84e8
ToppCell10x5'-blood-Lymphocytic_Invariant-Inducer-like-ILC3|blood / Manually curated celltypes from each tissue

CFH LINC00473 PLXNA1 WDR72

2.22e-04165804f012a27ece54c0f7b73a2f4f89c6ee8b865f8782
ToppCellControl-Epithelial-Mesothelial|Control / Disease state, Lineage and Cell class

CFH LINC00473 CFI ZFPM2

2.27e-041668041ed3788257e14f097862b999f020bfe2a57de52b
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CFH CFI SLC6A14 AMIGO1

2.27e-0416680489e2b8453180983533faccb4275867861876d7ee
ToppCell368C-Myeloid-Monocyte-CD16+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ICOS LRP2 CFI SLC6A14

2.32e-04167804dbd2b9f2f4ba7be5fdf8318094e6b078cb1d1c43
ToppCell3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC6A18 ABCC8 PAX4 PMFBP1

2.32e-041678045accd0bc7c95089feb2c09376d12cd8bd3773775
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-Pleural_Mac|Myeloid_cells / Location, Cell class and cell subclass

JADE3 PRR14L HEATR5B STAG3

2.38e-041688048697b40b2ec2cce68ef3beb4792eb3eff29be053
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PLA2R1 ADGRA2 ZFPM2

2.38e-04168804d19a115365c5415e51c039718d7669de788fcf33
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH NTRK3 SLC1A2 ZFPM2

2.38e-041688044b2d29a7843bf45922038c093ca7ec0600756adc
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

EFCAB12 OSBPL6 CFAP69 DNAH9

2.43e-04169804fba841664939c771881ba97f14ef1df6635c04ff
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH MRC2 ADGRA2 ZFPM2

2.43e-04169804a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCell368C-Myeloid-Monocyte-CD16+_Monocyte|Monocyte / Donor, Lineage, Cell class and subclass (all cells)

ICOS LRP2 CFI SLC6A14

2.49e-041708044a19c7e3bb0f9c2601a10debe7000066789b4150
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LINC00473 ABCC8 NTRK3 ADGRA2

2.49e-0417080499dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LINC00473 ABCC8 NTRK3 ADGRA2

2.49e-041708043a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LINC00473 ABCC8 NTRK3 ADGRA2

2.49e-04170804cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH NTRK3 SLC1A2 ZFPM2

2.54e-041718045d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTS19 PLA2R1 ZFPM2

2.60e-041728046c17a1e586a72d1bd80c20c06370429c61dc9f85
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH PLOD3 GRN TNFRSF1B

2.66e-04173804807183fc23478da9451906dacd88de4e73112e0d
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH PLOD3 GRN TNFRSF1B

2.66e-041738042e683ec555dc0036875e0f5674dcc5e93ead205d
ToppCellwk_15-18-Mesenchymal-Fibroblast-Mesenchymal_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

COL26A1 TECRL LRP1B PMFBP1

2.66e-04173804b43817a6b1ed8d6b5366702343be4311c0d52d83
ToppCellLeuk-UTI-Myeloid-cDC1|Leuk-UTI / Disease, Lineage and Cell Type

MRC2 CPNE3 OSBPL6 CFI

2.66e-04173804226bb8d881f32d65c60f5e4c034c6d465f8e7ba5
ToppCellfacs-Heart-RA-24m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH MMRN2 ZFHX2 ADGRA2

2.72e-0417480442dfb6f42b72e40e203b3ef341117bccf3553d54
ToppCellfacs-Heart-RA-24m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH MMRN2 ZFHX2 ADGRA2

2.72e-04174804f04edf2ca6788875c9918611e416fb739924382e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PLA2R1 SLC1A2 ZFPM2

2.78e-04175804795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCellfacs-Marrow-B-cells-24m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 LRP1B DNAH9 WDR72

2.78e-04175804887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCellP03-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DDR1 LAMA3 SLC6A14 CHST8

2.84e-04176804f3a54038cde58326f1caed96ecca33c141bcc8b3
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH NTRK3 SLC1A2 ZFPM2

2.90e-041778049ec7f1e64312d26d434b3312b58386715dbad644
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH NTRK3 SLC1A2 ZFPM2

2.90e-04177804016277dfd59b1793fddaaadc2b3f41622d76ce3a
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLXNA3 COL26A1 NTRK3 PLXNA1

2.90e-0417780430f82b04e48940bfcaf2c22677efe6d57ae3f1a7
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2-Sox4-POLYDENDROCYTE_(Neurogenesis.Sox4.Gabra5)|Hippocampus / BrainAtlas - Mouse McCarroll V32

PAPPA2 NTNG2 STAG3

2.96e-0472803480653f8bd0ef118cb8d541103692e3ec8a1b58d
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CFH COL26A1 LRP2 WDR72

2.96e-04178804544379f5a6145429762258d426b876bb36c112f5
ToppCellPND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DDR1 LAMA3 TECRL SLC6A14

2.96e-04178804a3af5d9c55858e36be0498081029ecb0acaeb3d3
ToppCellPND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DDR1 LAMA3 TECRL SLC6A14

2.96e-04178804b3b88989bd602cfb55bb5c47731deb99288a8952
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTS19 PLA2R1 ZFPM2

3.03e-041798047394e77e665bf16d3733df91bb12907be460ab44
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

WDR97 EFCAB12 CFAP69 DNAH9

3.03e-041798045e5f1cdf4aa66868d45b74ba91e20e848a3cbaff
ToppCellAT1_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

DDR1 PLA2R1 LAMA3 PLXNA1

3.03e-041798041603117b52623663458a977c94bf7f9f6c1114b8
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

INSR OSBPL6 LRP2 WDR72

3.09e-041808041363b3254470f6ff98630d1df83a1bdbacc137e0
ToppCellCiliated_cells-B-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

ADAMTS19 OSBPL6 CFAP69 DNAH9

3.09e-04180804bdea5ec6b60fc8c7cce4d71db5da74ac8675e211
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRPC7 ABCC8 PAX4 LRP1B

3.09e-041808046b1606238417490e0d9930870a7827419d1c3737
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A18 INSR LRP2 GP2

3.16e-04181804c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH COL26A1 LAMA3 ZFPM2

3.16e-041818045f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH COL26A1 LAMA3 ZFPM2

3.16e-04181804c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 LAMA3 LRP1B GP2

3.22e-04182804a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCellfacs-Large_Intestine-Distal-24m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 ABCC8 PAX4 DNAH9

3.22e-04182804398ce074a04f6482470b488f1affae4af7d2ec58
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTS19 PLA2R1 ZFPM2

3.29e-04183804848fc6dd129150897ee339343e83c645b6e779eb
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTS19 PLA2R1 ZFPM2

3.29e-041838047c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PLA2R1 SLC1A2 ZFPM2

3.36e-04184804e061e85c4bb19f49f6451ddd7a9077d7378ee365
DiseaseMonogenic diabetes

ABCC8 INSR PAX4

8.28e-0616743C3888631
DiseaseDrusen, Radial, Autosomal Dominant

CFH CFI

1.86e-053742C1852021
DiseaseMalattia Leventinese

CFH CFI

1.86e-053742C1852020
DiseaseDOYNE HONEYCOMB RETINAL DYSTROPHY

CFH CFI

1.86e-053742C1832174
DiseaseDiabetes Mellitus, Non-Insulin-Dependent

ABCC8 INSR PAX4 TNFRSF1B SLC1A2 GP2

2.00e-05221746C0011860
DiseaseNAD-dependent protein deacylase sirtuin-5, mitochondrial measurement

CFH ZFPM2

3.71e-054742EFO_0801822
DiseaseHELLP Syndrome

CFH CFI

3.71e-054742C0162739
Diseasesomatostatin-28 measurement

CFH ZFPM2

9.25e-056742EFO_0020745
Diseasegalectin-7 measurement

CFH ZFPM2

9.25e-056742EFO_0022034
Diseasepleckstrin homology domain-containing family A member 1 measurement

CFH ZFPM2

1.29e-047742EFO_0802873
Disease1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 measurement

CFH MMRN2

1.29e-047742EFO_0020108
DiseaseFamilial hyperinsulinism

ABCC8 INSR

1.72e-048742cv:C3888018
Diseaseatypical hemolytic-uremic syndrome (is_implicated_in)

CFH CFI

1.72e-048742DOID:0080301 (is_implicated_in)
DiseaseC3 glomerulopathy

CFH CFI

2.21e-049742C4087273
DiseaseAtypical hemolytic-uremic syndrome

CFH CFI

2.21e-049742cv:C2931788
DiseaseHemolytic-uremic syndrome

CFH CFI

2.21e-049742cv:C0019061
Diseasesynaptotagmin-11 measurement

CFH ZFPM2

2.21e-049742EFO_0802108
DiseaseAtypical Hemolytic Uremic Syndrome

CFH CFI

2.76e-0410742C2931788
DiseaseUDP-glucuronic acid decarboxylase 1 measurement

CFH ZFPM2

3.36e-0411742EFO_0803221
Diseasetype 1 diabetes mellitus

ICOS PAX4 LRP1B SLC1A2 GP2

3.62e-04242745MONDO_0005147
Diseasevascular endothelial growth factor A measurement

CFH ZFPM2

4.03e-0412742EFO_0010804
DiseaseTakayasu arteritis

DDR1 EHMT2 LRP1B ZFPM2

5.32e-04148744EFO_1001857
Diseasemembranous glomerulonephritis (biomarker_via_orthology)

CFH LRP2

5.54e-0414742DOID:10976 (biomarker_via_orthology)
Diseasewet macular degeneration

CFH CFI

5.54e-0414742EFO_0004683
DiseaseC-C motif chemokine 19 measurement

CFH ICOS

5.54e-0414742EFO_0008047
DiseaseMaturity onset diabetes mellitus in young

ABCC8 PAX4

5.54e-0414742C0342276
Diseaseresponse to triptolide, cytotoxicity measurement

TECRL ADGRA2

7.28e-0416742EFO_0006952, EFO_0007662
DiseaseC-X-C motif chemokine 6 measurement

CFH ZFPM2

7.28e-0416742EFO_0008059
DiseaseMalignant Glioma

NTRK3 SUZ12 DMXL1

7.35e-0470743C0555198
Diseasemixed gliomas

NTRK3 SUZ12 DMXL1

7.35e-0470743C0259783
Diseaselupus nephritis (is_implicated_in)

CFH TNFRSF1B

9.25e-0418742DOID:0080162 (is_implicated_in)
DiseaseAge-related macular degeneration

CFH CFI

9.25e-0418742cv:C0242383
Diseasehepatocellular carcinoma (is_marker_for)

DDR1 PLOD3 INSR RTKN LRP1B

9.69e-04301745DOID:684 (is_marker_for)
DiseaseCongenital diaphragmatic hernia

INSR ZFPM2

1.26e-0321742C0235833
DiseaseGlioma

NTRK3 SUZ12 DMXL1

1.38e-0387743C0017638
Diseasenephrosis (biomarker_via_orthology)

CFH LRP2

1.39e-0322742DOID:2527 (biomarker_via_orthology)
Diseasedescending aortic diameter

CFH PAPPA2 ABCC8

1.43e-0388743EFO_0021788
Diseasegout

NTNG2 ABCC8 LRP2 UBE2Q2

1.51e-03196744EFO_0004274
Diseaseatrophic macular degeneration

CFH CFI

1.79e-0325742EFO_1001492
DiseaseNeonatal diabetes mellitus

ABCC8 INSR

1.79e-0325742C0158981
Diseasediffusing capacity of the lung for carbon monoxide

COL26A1 INSR LRP1B

1.83e-0396743EFO_0009369
Diseasemacular degeneration (is_implicated_in)

CFH CFI

2.09e-0327742DOID:4448 (is_implicated_in)
Diseasecorpus callosum mid-anterior volume measurement

SLC1A2 WDR72

2.09e-0327742EFO_0010297
DiseaseTYPE 2 DIABETES MELLITUS

ABCC8 PAX4

2.25e-0328742125853
DiseaseType 2 diabetes mellitus

ABCC8 PAX4

2.25e-0328742cv:C0011860
Diseaseamyotrophic lateral sclerosis (is_marker_for)

GRN SLC1A2

2.41e-0329742DOID:332 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
TPEAYWICLACVRLG

ACSM6

121

Q6P461
LYLTPCRCWCRGVEK

AMIGO1

391

Q86WK6
WQRCIEGTCVCKLPY

CFI

51

P05156
SQRWLPRVVCSCLYG

ADGRA2

1041

Q96PE1
CPQGLYELMLRCWSR

DDR1

876

Q08345
GASYSCCRPLLDKWP

GRN

36

P28799
WRPFKISLNSLCYGD

CPNE3

191

O75131
LCGQLSIRCWYDKDG

EHMT2

986

Q96KQ7
QDGWSPAVPCLRKCY

CFH

376

P08603
LCGVKKLPWSCDSRY

DMAC2L

26

Q99766
LSLYQTNWKCCPVTG

DMXL1

2811

Q9Y485
LQCWKLCKSYGLPLT

EFCAB12

396

Q6NXP0
CLLYPDTDWCPRQKQ

RFNG

311

Q9Y644
TFKCLGDQWPVYCRV

ADAMTS19

1161

Q8TE59
WLACALYVACRKSVP

RBL2

86

Q08999
YDCVISSPRKGWALL

PLOD3

696

O60568
WLLLCGCFQSKVPFR

GPR6

341

P46095
YFSCPSGRCILNTWI

LRP1B

2686

Q9NZR2
EGPTCSRCKLLYWNL

LAMA3

606

Q16787
CPAKCSFWRIFLLGS

NTRK3

6

Q16288
QKVLTSLAWRCCPGY

MMRN2

111

Q9H8L6
PCKSCGIWYRSERNL

ZFPM2

251

Q8WW38
CYRGEGKLSLPWLLN

PLXNA1

376

Q9UIW2
ALLYKCWAQRPSCGL

PLXNA3

781

P51805
NSACWLGILLCLYQL

IPO7

141

O95373
LEGTPWCNLRYCTVP

GP2

166

P55259
ALYSPGKRLQEWCSV

PEDS1

36

A5PLL7
DWGDQRCLTALPYIC

MRC2

936

Q9UBG0
WSCPESGRCISIYKV

LRP2

271

P98164
YKECLSCWLESGIPN

METTL15P1

11

P0C7V9
LDYCLKGLKLPSRTW

INSR

671

P06213
YKECLSCWLESGIPN

METTL15

11

A6NJ78
LYCGVAPSAKCIWRP

OSBPL6

801

Q9BZF3
SQPGCAYAILLCTWK

ITFG2

201

Q969R8
LGLQDNPWACDCRLY

LRIT1

196

Q9P2V4
LEPLGPSCYQLCWAT

PAX4

271

O43316
YESQLCCQLKFWLPI

ICOS

131

Q9Y6W8
GLLYPVALLRCQDCW

IGF2BP2-AS1

46

Q96M15
DGLWSLPEVYCKLEC

PAPPA2

1511

Q9BXP8
RTWLLQTCKSYAVPC

FZD7

501

O75084
CDPWVQAKCYQLLLS

HEATR5B

1896

Q9P2D3
CSAWLLASSCPRLYA

LINC00473

121

A8K010
WYSPLGIACLICGKI

SLC1A2

286

P43004
ECLPYAAWCQLAVAR

F8A1;

61

P23610
TQVCYLQRPITLWCG

FBXO24

401

O75426
VVCLIWATCKSYRSP

DNAH9

341

Q9NYC9
KSLPLWDGLCCRSQF

CENPI

441

Q92674
STLDSIWCCILGCYP

CFAP69

586

A5D8W1
SYRTVTVLEWRCCPG

COL26A1

106

Q96A83
CYGILKVPEGSWLCR

JADE3

231

Q92613
SWLCRSCVLGIYPQC

JADE3

241

Q92613
LCSPGCYRIWTKKRS

PRR14L

1826

Q5THK1
KPYNPILGETFRCCW

OSBPL5

446

Q9H0X9
WLQERAAPGACYLKC

ITPRIPL2

361

Q3MIP1
LAQETLWDLCKGFCP

FAM180B

151

Q6P0A1
CLPLASGDYDICKSW

NTNG2

11

Q96CW9
CLPQWSVPKDTCRLY

PMFBP1

866

Q8TBY8
NPAWLPLYGSVCCRL

RTKN

286

Q9BST9
LWCPTLKVLCYYGSQ

SMARCAD1

566

Q9H4L7
WLSKTNSCPLCRYEL

RNF181

106

Q9P0P0
CDCWPSLEIRALLYA

FAM78A

6

Q5JUQ0
LESCLRVNPKSYGTW

RABGGTA

96

Q92696
WFKRCFAGCLPESSL

TBC1D7

206

Q9P0N9
WRSRDCESTLPYICK

PLA2R1

341

Q13018
KLYPGWARAACVLLS

SLC6A18

561

Q96N87
PWRACAKYLSSAGIL

ABCC8

996

Q09428
RVLYCEVPKAGCSNW

CHST8

191

Q9H2A9
YGSPWCNKQITRCLI

CNOT1

1701

A5YKK6
WLICELCSLYNLPKH

UBE2Q2

101

Q8WVN8
RICKLCGNAFIWPSL

ZNF441

196

Q8N8Z8
FWLCLLCRLGFSKPQ

ZFHX2

236

Q9C0A1
VCCALSPRGEWIYCV

SMU1

446

Q2TAY7
TRWELYEPCCQLLQK

STAG3

716

Q9UJ98
CAAAVAYCLPREALW

WDR97

476

A6NE52
PWCTLNCRKLYSLLK

SUZ12

451

Q15022
CLLPWGVDKDLDYLC

WDR72

801

Q3MJ13
LVECWKDCLSIPYRL

PRKDC

2241

P78527
RICTCRPGWYCALSK

TNFRSF1B

116

P20333
CPKWYPSRVGLQLEC

TECRL

96

Q5HYJ1
LISCCRPASNWGPYL

SLC6A14

596

Q9UN76
KYGTRCSSCWLVPRK

ZGLP1

236

P0C6A0
AIAYWIAPCSKLGRT

TRPC7

366

Q9HCX4