Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	serine-type endopeptidase activity	TMPRSS2 MMP12 F2 MMP14	1.01e-04	190	26	4	GO:0004252
GeneOntologyMolecularFunction	serine-type peptidase activity	TMPRSS2 MMP12 F2 MMP14	1.40e-04	207	26	4	GO:0008236
GeneOntologyMolecularFunction	glycerophospholipid flippase activity	ABCA4 ATP10A	1.47e-04	14	26	2	GO:0140333
GeneOntologyMolecularFunction	serine hydrolase activity	TMPRSS2 MMP12 F2 MMP14	1.54e-04	212	26	4	GO:0017171
GeneOntologyMolecularFunction	endopeptidase activity	TMPRSS2 MMP12 F2 MMP14 MMP16	2.05e-04	430	26	5	GO:0004175
GeneOntologyMolecularFunction	flippase activity	ABCA4 ATP10A	2.19e-04	17	26	2	GO:0140327
GeneOntologyMolecularFunction	metalloendopeptidase activity	MMP12 MMP14 MMP16	4.97e-04	120	26	3	GO:0004222
GeneOntologyMolecularFunction	metalloaminopeptidase activity	MMP14 MMP16	5.20e-04	26	26	2	GO:0070006
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ABCA4 ATP10A	6.04e-04	28	26	2	GO:0140326
GeneOntologyMolecularFunction	peptidase activity	TMPRSS2 MMP12 F2 MMP14 MMP16	1.38e-03	654	26	5	GO:0008233
GeneOntologyMolecularFunction	aminopeptidase activity	MMP14 MMP16	1.42e-03	43	26	2	GO:0004177
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ABCA4 ATP10A	2.00e-03	51	26	2	GO:0140303
GeneOntologyMolecularFunction	metallopeptidase activity	MMP12 MMP14 MMP16	2.17e-03	200	26	3	GO:0008237
GeneOntologyMolecularFunction	metalloexopeptidase activity	MMP14 MMP16	3.73e-03	70	26	2	GO:0008235
GeneOntologyMolecularFunction	phospholipid transporter activity	ABCA4 ATP10A	4.16e-03	74	26	2	GO:0005548
GeneOntologyBiologicalProcess	collagen metabolic process	MMP12 F2 MMP14 MMP16	3.37e-05	148	26	4	GO:0032963
GeneOntologyBiologicalProcess	collagen catabolic process	MMP12 MMP14 MMP16	3.99e-05	53	26	3	GO:0030574
Domain	Pept_M10A_Zn_BS	MMP12 MMP14 MMP16	1.08e-06	15	26	3	IPR021158
Domain	Hemopexin_CS	MMP12 MMP14 MMP16	1.61e-06	17	26	3	IPR018486
Domain	Pept_M10A_stromelysin-type	MMP12 MMP14 MMP16	1.93e-06	18	26	3	IPR016293
Domain	PG_binding_1	MMP12 MMP14 MMP16	2.69e-06	20	26	3	PF01471
Domain	Peptidoglycan-bd-like	MMP12 MMP14 MMP16	2.69e-06	20	26	3	IPR002477
Domain	Hemopexin-like_dom	MMP12 MMP14 MMP16	4.16e-06	23	26	3	IPR000585
Domain	Hemopexin	MMP12 MMP14 MMP16	4.16e-06	23	26	3	PF00045
Domain	HEMOPEXIN	MMP12 MMP14 MMP16	4.16e-06	23	26	3	PS00024
Domain	-	MMP12 MMP14 MMP16	4.16e-06	23	26	3	2.110.10.10
Domain	HEMOPEXIN_2	MMP12 MMP14 MMP16	4.16e-06	23	26	3	PS51642
Domain	Hemopexin-like_repeat	MMP12 MMP14 MMP16	4.16e-06	23	26	3	IPR018487
Domain	HX	MMP12 MMP14 MMP16	4.16e-06	23	26	3	SM00120
Domain	Pept_M10A	MMP12 MMP14 MMP16	4.16e-06	23	26	3	IPR021190
Domain	M10A_MMP	MMP12 MMP14 MMP16	4.16e-06	23	26	3	IPR033739
Domain	Peptidase_M10	MMP12 MMP14 MMP16	4.75e-06	24	26	3	PF00413
Domain	ZnMc	MMP12 MMP14 MMP16	8.54e-06	29	26	3	SM00235
Domain	Peptidase_Metallo	MMP12 MMP14 MMP16	8.54e-06	29	26	3	IPR006026
Domain	DUF3377	MMP14 MMP16	1.12e-05	4	26	2	PF11857
Domain	Pept_M10A_metallopeptidase_C	MMP14 MMP16	1.12e-05	4	26	2	IPR021805
Domain	CYSTEINE_SWITCH	MMP12 MMP14 MMP16	2.46e-05	41	26	3	PS00546
Domain	Pept_M10_metallopeptidase	MMP12 MMP14 MMP16	2.85e-05	43	26	3	IPR001818
Domain	MetalloPept_cat_dom	MMP12 MMP14 MMP16	1.90e-04	81	26	3	IPR024079
Domain	-	MMP12 MMP14 MMP16	1.90e-04	81	26	3	3.40.390.10
Domain	ZINC_PROTEASE	MMP12 MMP14 MMP16	3.34e-04	98	26	3	PS00142
Domain	Abhydrolase_1	EPHX3 ABHD2	8.45e-04	31	26	2	PF00561
Domain	AB_hydrolase_1	EPHX3 ABHD2	9.58e-04	33	26	2	IPR000073
Domain	BTB-kelch_protein	KLHL13 KLHL15	1.62e-03	43	26	2	IPR017096
Domain	Kelch	KLHL13 KLHL15	2.94e-03	58	26	2	SM00612
Domain	BACK	KLHL13 KLHL15	3.14e-03	60	26	2	SM00875
Domain	BACK	KLHL13 KLHL15	3.24e-03	61	26	2	PF07707
Domain	BACK	KLHL13 KLHL15	3.24e-03	61	26	2	IPR011705
Domain	Kelch_1	KLHL13 KLHL15	4.25e-03	70	26	2	PF01344
Domain	Kelch_1	KLHL13 KLHL15	4.25e-03	70	26	2	IPR006652
Domain	ARM-like	SMG1 ARID1B CUL7	6.07e-03	270	26	3	IPR011989
Domain	TRYPSIN_SER	TMPRSS2 F2	6.92e-03	90	26	2	IPR033116
Domain	Galactose-bd-like	CUL7 PTPRM	7.53e-03	94	26	2	IPR008979
Domain	TRYPSIN_HIS	TMPRSS2 F2	8.98e-03	103	26	2	IPR018114
Domain	TRYPSIN_SER	TMPRSS2 F2	9.49e-03	106	26	2	PS00135
Domain	TRYPSIN_HIS	TMPRSS2 F2	9.66e-03	107	26	2	PS00134
Domain	Peptidase_S1A	TMPRSS2 F2	1.07e-02	113	26	2	IPR001314
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP12 MMP14 MMP16	1.35e-05	29	23	3	MM15981
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP12 MMP14 MMP16	1.50e-05	30	23	3	M39652
Pathway	WP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION	MMP12 MMP14 MMP16	5.50e-05	46	23	3	M46450
Pathway	REACTOME_TGFBR3_PTM_REGULATION	MMP14 MMP16	1.14e-04	10	23	2	MM17232
Pathway	REACTOME_TGFBR3_PTM_REGULATION	MMP14 MMP16	1.39e-04	11	23	2	M48251
Pathway	REACTOME_SIGNALING_BY_TGFBR3	MMP14 MMP16	5.25e-04	21	23	2	MM17231
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	MMP12 MMP14 MMP16	8.11e-04	114	23	3	MM14571
Pubmed	Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes.	MMP12 MMP14 MMP16	6.86e-08	11	27	3	10949161
Pubmed	Matrix metalloproteinases in tumor invasion.	MMP12 MMP14 MMP16	2.32e-07	16	27	3	10949577
Pubmed	Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor.	MMP12 MMP14 MMP16	2.32e-07	16	27	3	37701782
Pubmed	Novel G protein-coupled receptors: a gene family of putative human olfactory receptor sequences.	OR1D5 OR1D2	5.80e-07	2	27	2	1315913
Pubmed	Membrane-type MMPs enable extracellular matrix permissiveness and mesenchymal cell proliferation during embryogenesis.	MMP14 MMP16	5.80e-07	2	27	2	18022611
Pubmed	Matrix metalloproteinases.	MMP12 MMP14 MMP16	6.36e-07	22	27	3	10419448
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP12 MMP14 MMP16	6.36e-07	22	27	3	23421805
Pubmed	Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.	MMP12 MMP14 MMP16	8.35e-07	24	27	3	15734845
Pubmed	A cancer cell metalloprotease triad regulates the basement membrane transmigration program.	MMP14 MMP16	1.74e-06	3	27	2	16983145
Pubmed	Collagen I and thrombin activate MMP-2 by MMP-14-dependent and -independent pathways: implications for airway smooth muscle migration.	F2 MMP14	1.74e-06	3	27	2	17189319
Pubmed	Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization.	MMP14 MMP16	1.74e-06	3	27	2	9119382
Pubmed	Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development.	MMP14 MMP16	1.74e-06	3	27	2	18784838
Pubmed	Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry.	TMPRSS2 F2	1.74e-06	3	27	2	35294338
Pubmed	Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.	MMP12 MMP14 MMP16	2.93e-06	36	27	3	20587546
Pubmed	Changes in the expression of membrane type-matrix metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during treatment and their potential impact on the survival of patients with non-small cell lung cancer (NSCLC).	MMP14 MMP16	3.48e-06	4	27	2	35062057
Pubmed	Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII.	MMP12 MMP14	3.48e-06	4	27	2	10930399
Pubmed	Prion fragment peptides are digested with membrane type matrix metalloproteinases and acquire enzyme resistance through Cu²⁺-binding.	MMP14 MMP16	3.48e-06	4	27	2	24970228
Pubmed	Expression pattern of four membrane-type matrix metalloproteinases in the normal and diseased mouse mammary gland.	MMP14 MMP16	3.48e-06	4	27	2	15895410
Pubmed	mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue.	MMP14 MMP16	5.80e-06	5	27	2	12661033
Pubmed	MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding.	MMP14 MMP16	5.80e-06	5	27	2	29196321
Pubmed	Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the receptor protein of CRL2Prame complex.	CUL7 KLHL13 KLHL15	7.05e-06	48	27	3	33504946
Pubmed	The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells.	MMP14 MMP16	8.69e-06	6	27	2	14645246
Pubmed	Contributions of matrix metalloproteinases toward Meckel's cartilage resorption in mice: immunohistochemical studies, including comparisons with developing endochondral bones.	MMP12 MMP14	8.69e-06	6	27	2	17136358
Pubmed	Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion.	MMP14 MMP16	1.22e-05	7	27	2	19542530
Pubmed	Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.	MMP14 MMP16	1.22e-05	7	27	2	12879005
Pubmed	Membrane-type matrix metalloproteinases: Their functions and regulations.	MMP14 MMP16	1.22e-05	7	27	2	25794647
Pubmed	Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.	MMP12 F2 MMP14 MMP16	1.26e-05	186	27	4	20452482
Pubmed	A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).	MMP12 F2 MMP14 MMP16	1.26e-05	186	27	4	20673868
Pubmed	Mouse-human orthology relationships in an olfactory receptor gene cluster.	OR1D5 OR1D2	1.62e-05	8	27	2	11170746
Pubmed	Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.	KLHL13 KLHL15	3.18e-05	11	27	2	14528312
Pubmed	Differential expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) during mouse gonad development.	MMP12 MMP14	4.50e-05	13	27	2	12815621
Pubmed	Metalloproteinases promote plaque rupture and myocardial infarction: A persuasive concept waiting for clinical translation.	MMP12 MMP14	5.25e-05	14	27	2	25636537
Pubmed	Membrane-type MMPs are indispensable for placental labyrinth formation and development.	MMP14 MMP16	5.25e-05	14	27	2	20858856
Pubmed	Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.	MMP12 MMP14	5.25e-05	14	27	2	16236725
Pubmed	Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study.	GRID2 ABCA4	5.25e-05	14	27	2	23512105
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	ARFGEF3 SMG1 MYH7 MMP12 CPLANE1	5.98e-05	552	27	5	10737800
Pubmed	Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.	OR1D5 OR1D2	6.92e-05	16	27	2	10673334
Pubmed	Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families.	MMP12 MMP14	6.92e-05	16	27	2	20484597
Pubmed	A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity.	MMP12 MMP14	9.84e-05	19	27	2	24784232
Pubmed	Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.	MYH7 STAT5B	9.84e-05	19	27	2	21041952
Pubmed	ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.	MMP12 MMP14	9.84e-05	19	27	2	22014525
Pubmed	Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.	MYH7 EZH1	1.09e-04	20	27	2	22267199
Pubmed	Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice.	TMPRSS2 F2	1.21e-04	21	27	2	19592578
Pubmed	The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart.	MYH7 CUL7	1.33e-04	22	27	2	36877136
Pubmed	Perioperative genomic profiles using structure-specific oligonucleotide probes.	MYH7 F2	1.45e-04	23	27	2	19474452
Pubmed	A novel missense variant in CUL3 shows altered binding ability to BTB-adaptor proteins leading to diverse phenotypes of CUL3-related disorders.	KLHL13 KLHL15	1.45e-04	23	27	2	33130828
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ARFGEF3 TMPRSS2 CPLANE1 ATP10A	1.66e-04	361	27	4	26167880
Pubmed	Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth.	MMP12 MMP14	2.49e-04	30	27	2	22171010
Pubmed	Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.	ABCA4 PTPRM	2.84e-04	32	27	2	21546767
Pubmed	Update on the Kelch-like (KLHL) gene family.	KLHL13 KLHL15	4.67e-04	41	27	2	23676014
Pubmed	Substrate-trapping techniques in the identification of cellular PTP targets.	PTPRM STAT5B	6.67e-04	49	27	2	15588985
Pubmed	Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.	MMP12 MMP14 MMP16	7.52e-04	231	27	3	21048031
Interaction	KISS1 interactions	MMP14 MMP16 KLHL15	1.13e-06	17	25	3	int:KISS1
Interaction	MMP16 interactions	MMP12 MMP14 MMP16	1.36e-06	18	25	3	int:MMP16
Interaction	KLHL14 interactions	CUL7 KLHL13 KLHL15	7.33e-05	66	25	3	int:KLHL14
Interaction	MMP12 interactions	MMP12 MMP16	8.07e-05	11	25	2	int:MMP12
Interaction	PDCD6 interactions	TMPRSS2 MYH7 ARID1B CUL7	1.09e-04	204	25	4	int:PDCD6
Interaction	F12 interactions	CUL7 MMP12 MMP14	1.16e-04	77	25	3	int:F12
Cytoband	17p13.3	OR1D5 OR1D2	1.24e-03	88	27	2	17p13.3
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP12 MMP14 MMP16	4.08e-06	24	24	3	891
GeneFamily	Abhydrolase domain containing	EPHX3 ABHD2	3.84e-04	22	24	2	4
GeneFamily	Olfactory receptors, family 1	OR1D5 OR1D2	1.28e-03	40	24	2	147
GeneFamily	Kelch like\|BTB domain containing	KLHL13 KLHL15	1.41e-03	42	24	2	617
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KLHL13 KLHL15	1.35e-02	134	24	2	861
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRID2 MYH7 ATP10A ABHD2	3.23e-06	170	27	4	99dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRID2 MYH7 ATP10A ABHD2	3.23e-06	170	27	4	3a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRID2 MYH7 ATP10A ABHD2	3.23e-06	170	27	4	cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCell	10x5'v1-week_17-19-Myeloid_macrophage-stroma-osteoclast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ARFGEF3 DGKI MMP14 PTPRM	4.81e-06	188	27	4	762b52f21d2bc5409f86746a904c4358490be9c0
ToppCell	Macroglial-Polydendrocytes-PDGFRA---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DGKI GRID2 MMP16 ABHD2	6.14e-06	200	27	4	4fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCell	Macroglial-Polydendrocytes-PDGFRA-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DGKI GRID2 MMP16 ABHD2	6.14e-06	200	27	4	f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCell	Macroglial-Polydendrocytes-PDGFRA--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DGKI GRID2 MMP16 ABHD2	6.14e-06	200	27	4	cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCell	Macroglial-Polydendrocytes-PDGFRA----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DGKI GRID2 MMP16 ABHD2	6.14e-06	200	27	4	310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCell	Macroglial-Polydendrocytes-PDGFRA\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DGKI GRID2 MMP16 ABHD2	6.14e-06	200	27	4	c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCell	Macroglial-Polydendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DGKI GRID2 MMP16 ABHD2	6.14e-06	200	27	4	961858738ce35db8760c8c2e136f8369bc444ccf
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Rrad\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MYH7 LAYN ABHD2	7.82e-05	138	27	3	b3a040c5d0e1cc94d9b19155bca8700edba2d243
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crh_4930553C11Rik_\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAYN PTPRM KLHL13	8.34e-05	141	27	3	ad9a25569c142fb68ded34aeba0cd9be8124ce56
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Rxfp1_Prdm8\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAYN PTPRM KLHL13	1.02e-04	151	27	3	090b067873740c282865e2d02cf47d5cb3dd7607
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRID2 MMP16 ODAD3	1.33e-04	165	27	3	9de841c1c95967c562720feba930246debc626fd
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRID2 MMP16 ODAD3	1.33e-04	165	27	3	a612a7d3a5415ecacc3df8fbff0ce498f982aad0
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRID2 MMP16 ODAD3	1.33e-04	165	27	3	cdc94a640ec01c6892521bcd6f0ee0a66ff23866
ToppCell	facs-Tongue-nan-3m-Epithelial-basal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRID2 MYH7 LAYN	1.40e-04	168	27	3	ca0c4a819f9047fc40d224f7656fec60f6fa05d8
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_ISOC1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OR1D5 GRID2 PTPRM	1.50e-04	172	27	3	4f2303dee1f816093e580ea8a4a8d7e3e4f36368
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CUL7 LAYN MMP16	1.50e-04	172	27	3	8a6a2b4c6654bc976e60a02d0e7303a9071ed55f
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 TMPRSS2 MYH7	1.58e-04	175	27	3	0992de1c7bffcb6890584357a7a0a8955927da6c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_ISOC1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRID2 LAYN PTPRM	1.61e-04	176	27	3	d09e28606e2a6ed1f660898316765ca215085c18
ToppCell	3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA4 LAYN PTPRM	1.61e-04	176	27	3	5d3b2395bb842eea39175f5af6a4c76527e2fc31
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-GHRL+_NE_precursor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 MYH7 F2	1.66e-04	178	27	3	32cc4155267baf1b536a61310044e6502d09531f
ToppCell	10x5'v1-week_14-16-Myeloid_macrophage-stroma-osteoclast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ARFGEF3 DGKI MMP14	1.66e-04	178	27	3	a28683690ab8a60eb18f3ef87ea85da4e95b22df
ToppCell	3'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA4 LAYN MMP16	1.77e-04	182	27	3	82d6f72649c7dd4d64a84a9795edebdef2f285d6
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DGKI GRID2 KLHL15	1.86e-04	185	27	3	9faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_ISOC1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRID2 LAYN PTPRM	1.86e-04	185	27	3	ae53aa2ecfe418a5dbd7d963a995bc06dab94f56
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ABCA4 LAYN MMP16	1.86e-04	185	27	3	f9f48251bc33eb6bf2cff580d1a3207d21450aa0
ToppCell	10x3'2.3-week_14-16-Myeloid_macrophage-stroma-osteoclast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ARFGEF3 DGKI MMP14	1.86e-04	185	27	3	5ed49b6d8214c6119355a6d3ee4e25d40bcc0c53
ToppCell	facs-Lung-EPCAM-24m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 TMPRSS2 MYH7	1.89e-04	186	27	3	3c4994a1a7db06a61da8170e45e06aaef7896592
ToppCell	facs-Lung-EPCAM-24m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 TMPRSS2 MYH7	1.89e-04	186	27	3	a583d6fc0f1e729f6e9fd18d7b49d6eab9ca32b9
ToppCell	10x5'v1-week_12-13-Myeloid_macrophage-stroma-osteoclast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ARFGEF3 DGKI MMP14	1.89e-04	186	27	3	c9dfcf7bba7e5ef97ad5d9b7084fba932c91ab68
ToppCell	droplet-Kidney-nan-3m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRM ATP10A EPHX3	1.95e-04	188	27	3	ec0e241de2c8310b4417b9d4e2420d7a1662f1c0
ToppCell	Transplant_Alveoli_and_parenchyma-Endothelial-Lymphatic\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	ABCA4 LAYN MMP16	2.01e-04	190	27	3	8d6ec2fc0af19a5cb16fff34f8b131b71b33d45f
ToppCell	10x5'v1-week_12-13-Myeloid_macrophage-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ARFGEF3 DGKI MMP14	2.04e-04	191	27	3	4cebaf31d4f09f4ab273a819ad5cbff7d9a9b341
ToppCell	10x5'v1-week_12-13-Myeloid_macrophage\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ARFGEF3 DGKI MMP14	2.04e-04	191	27	3	be2fe2583bdcee0b35c43a347da9c4adb93e30e0
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRM ATP10A EPHX3	2.04e-04	191	27	3	b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRM ATP10A ABHD2	2.08e-04	192	27	3	9ae05db5bfb8b9d3935c0328e6f2d489d2b1ebfd
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRM ATP10A ABHD2	2.08e-04	192	27	3	a116db7dec495e5a0ba9c7537057cd1e567d7885
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRM ATP10A ABHD2	2.08e-04	192	27	3	66defad13bd8e79319741e43ddb056841710b1d7
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRID2 PTPRM STAT5B	2.11e-04	193	27	3	8b77625bf3c87d39767fb391d1beaca4ab02342b
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DGKI ARID1B PTPRM	2.11e-04	193	27	3	779276e775cb2492e8dd36436295a536084a6415
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRID2 PTPRM STAT5B	2.11e-04	193	27	3	2c15186d15545804cc262da9137ab825609d4b2c
ToppCell	facs-Lung-3m-Epithelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARFGEF3 TMPRSS2 MYH7	2.11e-04	193	27	3	db5e43e0b571737e7006365bdf0575340b8b900b
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-goblet-Goblet_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARFGEF3 ABCA4 ABHD2	2.14e-04	194	27	3	49cc5f5de4380302100e8cd937f08abe317ac75e
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-goblet\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARFGEF3 ABCA4 ABHD2	2.14e-04	194	27	3	fb935df966c451e659b8bde281f8aebcb632f6cf
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARFGEF3 TMPRSS2 PTPRM	2.14e-04	194	27	3	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARFGEF3 ABCA4 ABHD2	2.17e-04	195	27	3	c5f33b420c9ac14dc67fea632b8c2bc2442cbf3d
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARFGEF3 TMPRSS2 PTPRM	2.17e-04	195	27	3	9406866f99555198a9be311fbd65751b70f35446
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet-Goblet_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARFGEF3 ABCA4 ABHD2	2.17e-04	195	27	3	219c5d0cde7f6082755154f54db221413ec555cb
ToppCell	10x3'2.3-week_14-16-Myeloid_macrophage-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ARFGEF3 DGKI MMP14	2.20e-04	196	27	3	bd2c2de103e28b65ea537c22f71225cb0deef1e0
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MMP14 MMP16 KLHL13	2.20e-04	196	27	3	525d6c8a277364e624e7cc586275f8a891436b57
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRID2 MMP16 ATP10A	2.20e-04	196	27	3	1522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRID2 MMP16 ATP10A	2.20e-04	196	27	3	1c8294014713684b50885e638668f2ce75f357f0
ToppCell	10x3'2.3-week_14-16-Myeloid_macrophage\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ARFGEF3 DGKI MMP14	2.20e-04	196	27	3	072a4150ae521c6589b0f7cd60e975fb33715bf4
ToppCell	10x3'2.3-week_12-13-Myeloid_macrophage-stroma-osteoclast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ARFGEF3 DGKI MMP14	2.24e-04	197	27	3	1bf69db7e830315c8fa85e6e85b0cb94014e9169
ToppCell	NS-critical-d_07-13\|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARFGEF3 TMPRSS2 CPLANE1	2.27e-04	198	27	3	a6e11c87b31beffb6af190c64b4ef3ee1d9dab8d
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GRID2 ATP10A KLHL15	2.31e-04	199	27	3	5b6feacb0ca92c3fc6b327be978320426dcf6f68
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Club\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ARFGEF3 TMPRSS2 EPHX3	2.31e-04	199	27	3	2b357cc08c425a58d45aa6c086101c8fff53e218
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-dn_T\|Leuk-UTI / Disease, condition lineage and cell class	CUL7 LAYN ATP10A	2.31e-04	199	27	3	aa4d8ce8994e5032a33d5cc68c482882147cdc3b
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-NPM1P10--L5-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GRID2 LAYN PTPRM	2.34e-04	200	27	3	2ea33ac1970791e6a601ac1e407ef32e4833792d
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Mesenchymal\|2m / Sample Type, Dataset, Time_group, and Cell type.	ABCA4 LAYN ABHD2	2.34e-04	200	27	3	3b9dcc9df54fb81deb7dd4b2749b1bc746c1e563
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuroepithelial\|5w / Sample Type, Dataset, Time_group, and Cell type.	LAYN MMP14 ODAD3	2.34e-04	200	27	3	69707f9576d326a06faac49701ef5cd632e760f6
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuroepithelial-Proteoglycan-expressing_cell\|5w / Sample Type, Dataset, Time_group, and Cell type.	LAYN MMP14 ODAD3	2.34e-04	200	27	3	f94381d0a3b5b81cdbb13b75fc0e4910cbd70382
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-NPM1P10\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GRID2 LAYN PTPRM	2.34e-04	200	27	3	7b3284bf0000e14f5a51e4422231e5639a184579
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARFGEF3 TMPRSS2 ATP10A	2.34e-04	200	27	3	7c2d499af60654b7b28f172ac2c914ad49fb74b4
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-NPM1P10-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GRID2 LAYN PTPRM	2.34e-04	200	27	3	e957f5926675f6c29208cfc3203a19dab538df38
ToppCell	(6)_Macrophage-(60)_Macrophage\|(6)_Macrophage / shred on Cell_type and subtype	MMP12 MMP14	9.12e-04	74	27	2	356978d2ee61e7042d7a9ad3bc744d3e7a7f76c0
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Npsr1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAYN ATP10A	1.09e-03	81	27	2	5d9b08bc1ae6ecb894c88c9784fdc4203682d087
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Rxfp1_Eya1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAYN KLHL13	1.12e-03	82	27	2	42017b8ace6f142a8358213c95a2632226c3a867
ToppCell	Posterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Acta2Rgs5Rgs5_(Mural.Acta2Rgs5Rgs5)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MMP12 EPHX3	1.37e-03	91	27	2	b576c4ab6ec2f80682dd51dc72dde35f99b1c7eb
ToppCell	Posterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MMP12 EPHX3	1.37e-03	91	27	2	7a60989eeb495e42e72e6d5d403e8d34027f9bd0
ToppCell	Posterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Acta2Rgs5Rgs5_(Mural.Acta2Rgs5Rgs5)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MMP12 EPHX3	1.37e-03	91	27	2	8f072b10386ef2742e7f95dcfbc42bfacf2af5f1
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l15\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MMP12 ABHD2	2.14e-03	114	27	2	84318a25a701331ccd5e68221239c543b9c0cc54
ToppCell	LPS-IL1RA-Endothelial-Mes-Like\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DGKI KLHL13	2.26e-03	117	27	2	5a23770806b4612bed4ae6fd716abdec7f7f56c6
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Fam19a1_Pax6\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PTPRM KLHL13	2.41e-03	121	27	2	7f2057367777c6c92f596054cbc5fe567d079fbc
ToppCell	RV-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	MYH7 PTPRM	2.45e-03	122	27	2	1cb1dd03b2aaedbe04f3ed907568c3b7f54767b3
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Fam19a1_Tmem182\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PTPRM KLHL13	2.53e-03	124	27	2	690595d710b57b7cff8029a3bb06a8dd7e3c03c1
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TRBV29-1 MMP16	2.61e-03	126	27	2	feedea978d76de326c14da5149e57d0d767271b9
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TRBV29-1 MMP16	2.61e-03	126	27	2	6311cc64320db7e24a09065ebdf054f5f551b182
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Undifferentiated_Pleomorphic_Sarcoma-7\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	MMP14 ABHD2	2.65e-03	127	27	2	c4809d8502f460370f824719d69b13b400a2b202
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-11\|TCGA-Brain / Sample_Type by Project: Shred V9	TRBV29-1 EPHX3	2.65e-03	127	27	2	7c3f8c791567fff5d2f42c2c7d09c78ec6ca3afe
ToppCell	droplet-Heart-HEART-1m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MMP12 ABHD2	2.65e-03	127	27	2	983489a69d3b1f1fe21110a862ac1dba53e9d31c
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Cervical_Squamous_Cell_Carcinoma-4\|TCGA-Cervix / Sample_Type by Project: Shred V9	ABCA4 MMP16	2.69e-03	128	27	2	3ca9ae69fb8cb7f8acb7540aa71778bc917da4df
ToppCell	LPS-antiTNF-Myeloid-Dendritic_cells-pDC\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYH7 ATP10A	2.73e-03	129	27	2	454bae525f6db3d0dd6347d2a2c3ea9dda9cd212
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Fam19a1_Tmem182\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PTPRM KLHL13	2.77e-03	130	27	2	8bd038b0423960ffdc6c8b128c46a55386f9c58c
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Fam19a1_Pax6\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PTPRM KLHL13	2.77e-03	130	27	2	60e28d452d0e2af768459ba8dbe998117c94a251
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_STALK\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	LAYN ATP10A	2.82e-03	131	27	2	308ddb7fe113eac5dbeb9cb0b688d9e09275ce5e
ToppCell	facs-Thymus-Epithelium-3m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	F2 EPHX3	2.86e-03	132	27	2	6f711fe84135406a8114a898a14c5ea0dfad74f2
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Mme_Fam114a1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PTPRM KLHL13	2.90e-03	133	27	2	fc319644868078ea0f88a71d55f5e858c6848b50
ToppCell	RA-15._Ventricular_Cardiomyocyte_III\|RA / Chamber and Cluster_Paper	LAYN ODAD3	2.94e-03	134	27	2	60ee3accc54108e5b9a0018f6aa8488dc39d5ade
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Rxfp1_Eya1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAYN KLHL13	2.94e-03	134	27	2	657ad905b40ec3f82acdef824431b8276d291ef7
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Rectal_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	LAYN ODAD3	3.03e-03	136	27	2	feb957df4bff3266cb9a7382b16fc927ae03b9b4
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRID2 MYH7	3.07e-03	137	27	2	4dcb15de821439011df1bb0bbd7682d674bd725d
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRID2 MYH7	3.07e-03	137	27	2	c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCell	TCGA-Thymus-Primary_Tumor-Thymoma-Type_A\|TCGA-Thymus / Sample_Type by Project: Shred V9	ABCA4 ODAD3	3.34e-03	143	27	2	2d77eaa8b4d8d2cec3f3e52d73502b3e2150f925
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Tacstd2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PTPRM KLHL13	3.34e-03	143	27	2	24fd24846fbef049af669a57d42fcc18928d2b27
ToppCell	facs-MAT-Fat-18m-Epithelial-epithelial_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS2 MMP12	3.39e-03	144	27	2	fd852095dcd716ac53b0fd25d83e6f454b2ae794
ToppCell	facs-MAT-Fat-18m-Epithelial-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS2 MMP12	3.39e-03	144	27	2	65ffd8a1620b178d995fe8c913871f0b376b896f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DGKI MMP16	3.39e-03	144	27	2	cc11cce43d1af8ac63140d05faf215ae9a10cde1
Computational	Genes in the cancer module 107.	TMPRSS2 MMP12 F2 MMP14	7.65e-06	79	18	4	MODULE_107
Computational	Catabolic peptidases.	TMPRSS2 MMP12 F2 MMP14	1.23e-05	89	18	4	MODULE_209
Computational	Genes in the cancer module 172.	TMPRSS2 MMP12 F2 MMP14	1.66e-05	96	18	4	MODULE_172
Computational	Neighborhood of SMO	F2 MMP16 STAT5B	1.27e-04	60	18	3	GCM_SMO
Computational	MMPs.	MMP12 MMP14	5.46e-04	21	18	2	MODULE_562
Computational	Genes in the cancer module 210.	MMP12 MMP14	9.76e-04	28	18	2	MODULE_210
Computational	Serine proteases.	TMPRSS2 F2	1.89e-03	39	18	2	MODULE_109
Computational	Metal ion (zinc) binding.	MMP12 MMP14	2.51e-03	45	18	2	MODULE_280
Drug	0317956-0000 [391210-11-0]; Up 200; 10uM; MCF7; HT_HG-U133A	TMPRSS2 CUL7 MMP16 ATP10A ABHD2	2.43e-06	194	26	5	3855_UP
Drug	Batimastat	MMP12 MMP16	3.76e-06	3	26	2	DB03880
Drug	malolactomycin D	MMP12 MMP14 MMP16	6.41e-06	32	26	3	CID006449115
Drug	isoflavone	ABCA4 MMP12 MMP14 MMP16	2.75e-05	155	26	4	CID000072304
Drug	carvedilol	MYH7 MMP12 MMP14 MMP16	3.19e-05	161	26	4	CID000002585
Drug	Marimastat	MMP12 MMP16	3.50e-05	8	26	2	DB00786
Drug	CGS 27023A	MMP14 MMP16	4.49e-05	9	26	2	ctd:C097658
Drug	AC1L1DD6	MMP12 F2 MMP14 MMP16	4.82e-05	179	26	4	CID000002299
Drug	diacerein	MMP12 MMP14 MMP16	5.02e-05	63	26	3	CID000026248
Drug	C75; Down 200; 10uM; PC3; HT_HG-U133A	TMPRSS2 MMP14 MMP16 OR1D2	6.21e-05	191	26	4	6399_DN
Drug	Beta-sistosterol [83-46-5]; Down 200; 9.6uM; MCF7; HT_HG-U133A	TMPRSS2 MMP14 ABHD2 OR1D2	6.47e-05	193	26	4	4154_DN
Drug	Cholecalciferol [67-97-0]; Down 200; 10.4uM; PC3; HT_HG-U133A	TMPRSS2 CPLANE1 MMP14 MMP16	6.60e-05	194	26	4	6656_DN
Drug	Sulfanilamide [63-74-1]; Up 200; 23.2uM; PC3; HT_HG-U133A	TMPRSS2 MMP14 ATP10A EPHX3	6.60e-05	194	26	4	4474_UP
Drug	Gibberellic acid [77-06-5]; Up 200; 11.6uM; MCF7; HT_HG-U133A	TMPRSS2 EZH1 ABHD2 OR1D2	6.86e-05	196	26	4	7330_UP
Drug	Ofloxacin [82419-36-1]; Down 200; 11uM; PC3; HT_HG-U133A	EZH1 MMP14 ABHD2 OR1D2	6.86e-05	196	26	4	3673_DN
Drug	Epicatechin-(-) [154-23-4]; Down 200; 13.8uM; MCF7; HT_HG-U133A	TMPRSS2 CUL7 MMP14 OR1D2	6.86e-05	196	26	4	4419_DN
Drug	Sotalol hydrochloride [959-24-0]; Down 200; 13uM; MCF7; HT_HG-U133A	TMPRSS2 CUL7 EZH1 ABHD2	7.00e-05	197	26	4	4160_DN
Drug	Dropropizine (R,S) [17692-31-8]; Up 200; 17uM; PC3; HT_HG-U133A	CUL7 MMP16 STAT5B OR1D2	7.00e-05	197	26	4	5106_UP
Drug	Citalopram hydrobromide [59729-32-7]; Up 200; 1uM; PC3; HT_HG-U133A	TMPRSS2 CUL7 MMP16 OR1D2	7.00e-05	197	26	4	4555_UP
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Up 200; 25.2uM; MCF7; HT_HG-U133A	CUL7 MMP14 MMP16 ABHD2	7.00e-05	197	26	4	3836_UP
Drug	Spironolactone [52-01-7]; Down 200; 9.6uM; MCF7; HT_HG-U133A	CUL7 EZH1 MMP16 ABHD2	7.14e-05	198	26	4	2226_DN
Drug	Trapidil [15421-84-8]; Up 200; 19.4uM; MCF7; HT_HG-U133A	TMPRSS2 MMP14 MMP16 ABHD2	7.28e-05	199	26	4	6515_UP
Drug	Diperodon hydrochloride [537-12-2]; Down 200; 9.2uM; MCF7; HT_HG-U133A	TMPRSS2 CUL7 EZH1 MMP16	7.28e-05	199	26	4	6836_DN
Drug	Vitexin [3681-93-4]; Down 200; 9.2uM; MCF7; HT_HG-U133A	TMPRSS2 MMP14 MMP16 ABHD2	7.42e-05	200	26	4	4413_DN
Drug	S(+)-Terguride [37686-84-3]; Up 200; 11.8uM; MCF7; HT_HG-U133A	TMPRSS2 MYH7 MMP14 OR1D2	7.42e-05	200	26	4	5400_UP
Drug	AC1L1GXT	MMP12 MMP14 MMP16	8.12e-05	74	26	3	CID000003890
Drug	closantel	MMP12 F2	9.71e-05	13	26	2	CID000042574
Drug	Ageladine A	MMP12 MMP14	1.13e-04	14	26	2	ctd:C482289
Drug	Cysteamine	MMP12 MMP14	1.13e-04	14	26	2	ctd:D003543
Drug	quinacrine	MMP12 F2 MMP14 MMP16	1.57e-04	243	26	4	CID000000237
Drug	enantio-PAF-C16	MMP12 F2 MMP14 MMP16	1.60e-04	244	26	4	CID000002499
Drug	MMI270	MMP12 MMP16	1.90e-04	18	26	2	CID000446504
Drug	glycidamide	TMPRSS2 GRID2 MMP16	2.11e-04	102	26	3	CID000091550
Drug	Inhibitor 3	F2 MMP14 STAT5B	2.17e-04	103	26	3	CID005327302
Drug	4-aminoquinoline	ABCA4 MMP12	2.60e-04	21	26	2	CID000068476
Drug	AC1NRC4A	MYH7 MMP12	2.86e-04	22	26	2	CID005288793
Drug	DA-125	MMP12 MMP16	4.01e-04	26	26	2	CID000114758
Drug	pyrazolanthrone	MYH7 MMP12 F2 MMP14	4.59e-04	322	26	4	ctd:C432165
Drug	pirfenidone	MMP12 MMP14 MMP16	5.11e-04	138	26	3	CID000040632
Drug	PF-00356231	MMP12 F2	5.35e-04	30	26	2	CID000448942
Drug	Ataa	MMP12 MMP14	5.35e-04	30	26	2	CID000195836
Drug	mercuric acetate	MMP12 MMP16	5.35e-04	30	26	2	CID000015337
Drug	Nitric Oxide	MYH7 EZH1 F2 STAT5B	5.39e-04	336	26	4	ctd:D009569
Drug	Dietary Sucrose	DGKI GRID2 MYH7 ABCA4 ATP10A KLHL15	5.58e-04	942	26	6	ctd:D019422
Drug	Vgvapg	MMP12 MMP14	5.71e-04	31	26	2	CID000124934
Drug	Ro 44-9883	F2 MMP14	5.71e-04	31	26	2	CID000071453
Drug	peroxynitrite	MMP12 F2 MMP14 MMP16	7.97e-04	373	26	4	CID000104806
Drug	titanium	MMP12 MMP14 MMP16	9.37e-04	170	26	3	CID000023963
Drug	latanoprost acid	MMP12 MMP16	9.52e-04	40	26	2	CID006441636
Drug	valinomycin; Up 200; 0.1uM; PC3; HT_HG-U133A	CUL7 MMP16 ATP10A	1.09e-03	179	26	3	5962_UP
Disease	Marfan syndrome (is_marker_for)	MMP12 MMP14	4.83e-06	4	27	2	DOID:14323 (is_marker_for)
Disease	thoracic aortic aneurysm (is_marker_for)	MMP12 MMP14	7.29e-05	14	27	2	DOID:14004 (is_marker_for)
Disease	ischemia (implicated_via_orthology)	ARID1B MMP14	1.09e-04	17	27	2	DOID:326 (implicated_via_orthology)
Disease	esophagus adenocarcinoma (is_implicated_in)	MMP12 MMP14	1.68e-04	21	27	2	DOID:4914 (is_implicated_in)
Disease	anti-basement membrane glomerulonephritis (biomarker_via_orthology)	MMP12 MMP14	3.45e-04	30	27	2	DOID:4780 (biomarker_via_orthology)
Disease	clear cell renal cell carcinoma (is_marker_for)	MMP12 F2	4.18e-04	33	27	2	DOID:4467 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PQIWYFFDNSTQMNM	ABCA4	436	P78363
FMQWDQCRRFYNFLM	ABHD2	246	P08910
QQNMWAARNDMPYPY	ARID1B	1531	Q8NFD5
QNMEEYRPRTFWFNM	ATP10A	1161	O60312
FWRVRNNQVMDGYPM	MMP14	341	P50281
VDNQYWRYDERRQMM	MMP12	396	P39900
VYERMFNWMVTRINA	MYH7	431	P12883
PYMFQWNDDRCNMKN	LAYN	166	Q6UX15
LNPFERDSMYSQMWR	GRID2	696	O43424
RLFYMVRAQAWSQDM	CUL7	986	Q14999
VFRFDPRYNKWMQVA	KLHL13	411	Q9P2N7
RYDPRQNSWLQMADM	KLHL15	351	Q96M94
EWAYRMLPFSRFFNM	CPLANE1	1326	Q9H799
MFMWYLNPRQVFDLS	DGKI	396	O75912
AEYWRIRAMAQQVFM	ARFGEF3	1656	Q5TH69
QSNPQEMHQYMWAFL	EPHX3	341	Q9H6B9
RMVQQFQFLGWPMYR	PTPRM	1341	P28827
PEQQRILFWMFLSMY	OR1D2	21	P34982
PEQQRILFWMFLSMY	OR1D5	21	P58170
LRQRWSMYQMEVIFG	ODAD3	346	A5D8V7
RPWMQALRYTMYQNQ	SMG1	1391	Q96Q15
QERMFWNLMPFTTRD	STAT5B	636	P51692
NVMVFTDWIYRQMRA	TMPRSS2	476	O15393
WRVRNNRVMDGYPMQ	MMP16	366	P51512
NRVMDGYPMQITYFW	MMP16	371	P51512
MYSWSPLQQNFMVED	EZH1	111	Q92800
DSQVTMMFWYRQQPG	TRBV29-1	41	A0A5B7
MMFWYRQQPGQSLTL	TRBV29-1	46	A0A5B7
PFVMKSPFNNRWYQM	F2	571	P00734