Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Pubmed

The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice.

CNTNAP3B CNTNAP3

4.71e-06276231150793
Pubmed

Apoptotic Endonuclease EndoG Inhibits Telomerase Activity and Induces Malignant Transformation of Human CD4+ T Cells.

ENDOG TERT

4.71e-06276228320284
Pubmed

Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task.

CNTNAP3B CNTNAP3

4.71e-06276226807827
Pubmed

[Apoptotic endonuclease EndoG regulates alternative splicing of human telomerase catalytic subunit hTERT].

ENDOG TERT

4.71e-06276227797329
Pubmed

Alternative splicing of telomerase catalytic subunit hTERT generated by apoptotic endonuclease EndoG induces human CD4+ T cell death.

ENDOG TERT

4.71e-06276228886883
Pubmed

The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number.

PCDHB18P PCDHB8 PCDHB2

1.11e-052076311322959
Pubmed

Identification and characterization of Iporin as a novel interaction partner for rab1.

GOLGA2 RUSC2

2.82e-05476215796781
Pubmed

In trans neuregulin3-Caspr3 interaction controls DA axonal bassoon cluster development.

CNTNAP3B CNTNAP3

7.03e-05676234143959
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

MYCBP2 SAFB2 CCDC85C NEURL4 LRRC41

1.04e-0421276533853758
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

PIK3CB AASS NOXA1 ZMYND8 TANGO2 TERT NEURL4 PRDX6 LRRC41

1.85e-0492576928986522
Pubmed

Gene targeting approaches to analyzing hypertension.

NPR1 CYP11B2

2.56e-041176210405217
Pubmed

Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.

PCDHB18P PCDHB8 PCDHB2

2.70e-045776332633719
Pubmed

CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.

PCDHB18P PCDHB8 PCDHB2

2.84e-045876330377227
Pubmed

Multiple influences on the migration of precerebellar neurons in the caudal medulla.

ADCYAP1 SEMA4C

3.07e-041276211807023
Pubmed

Protocadherins.

PCDHB8 PCDHB2

3.62e-041376212231349
Pubmed

Commissural neurons transgress the CNS/PNS boundary in absence of ventricular zone-derived netrin 1.

PRSS56 ROBO3

4.22e-041476229343638
Pubmed

Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.

PCDHB18P PCDHB8 PCDHB2

4.54e-046876311230163
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

ZNF142 AASS BARD1 ADCK2 FER1L5 NDUFV2 LRRC41

4.95e-0463876731182584
Pubmed

A striking organization of a large family of human neural cadherin-like cell adhesion genes.

PCDHB18P PCDHB8 PCDHB2

5.37e-047276310380929
Pubmed

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

NAT2 TERT

5.54e-041676220972438
Pubmed

A unique role of cohesin-SA1 in gene regulation and development.

PCDHB18P PCDHB8

5.54e-041676222415368
Pubmed

Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.

PCDHB18P PCDHB8 PCDHB2

5.81e-047476310817752
Pubmed

Cell adhesion molecule contactin-associated protein 3 is expressed in the mouse basal ganglia during early postnatal stages.

CNTNAP3B CNTNAP3

6.27e-041776226389685
Pubmed

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.

PCDHB18P PCDHB8 PCDHB2

6.53e-047776310835267
Pubmed

A physical interaction network of dengue virus and human proteins.

GOLGA2 PRDX6

7.05e-041876221911577
Pubmed

Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.

PCDHB18P PCDHB8 PCDHB2

7.30e-048076310716726
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SHROOM4 SAFB2 ALPK1 NEURL4 PRDX6 SEMA4C

7.44e-0449376615368895
Pubmed

Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting.

PCDHB8 PCDHB2

7.87e-041976228066179
Pubmed

Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome.

PCDHB18P PCDHB8

7.87e-041976223920377
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ZNF142 AATK ZMYND8

9.32e-048776312465718
Pubmed

FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.

CNTNAP3B CNTNAP3

1.06e-032276226494785
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

MYCBP2 ZMYND8 SAFB2 RPRD2 GOLGA2 RUSC2

1.43e-0356076621653829
Pubmed

Genome-wide association study identifies multiple loci associated with bladder cancer risk.

NAT2 TERT

1.48e-032676224163127
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

AATK MYCBP2 RPRD2 ALPK1

1.52e-0322576412168954
Pubmed

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

JPH4 NEURL4 CAPN10

1.69e-0310776311347906
Pubmed

Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice.

PCDHB8 PCDHB2

1.72e-032876233523829
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

NYNRIN MAGEE1 UAP1L1 NEURL4

1.73e-0323376437704626
Pubmed

Zfhx3 is required for the differentiation of late born D1-type medium spiny neurons.

CNTNAP3B CNTNAP3

1.84e-032976231491374
Pubmed

HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA.

BARD1 NEURL4

2.10e-033176230279242
Pubmed

Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones.

CYP2R1 CYP11B2

2.10e-033176215583024
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

EAPP CENPB NYNRIN NOXA1 ZMYND8 MAGEE1

2.16e-0360876616713569
GeneFamilyHelix-turn-helix CENPB type domain containing

CENPB TIGD6

5.28e-0413482533
GeneFamilyClustered protocadherins

PCDHB18P PCDHB8 PCDHB2

6.53e-046448320
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP3B NPR1 AATK PI16 TANGO2

8.81e-061637651feb4ef7b8abcfca9a72c8d13c40548de79e7db2
ToppCellPosterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Htra1)--|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

AASS PRSS56 ERMAP GRIN2C

1.44e-0586764c1181a7e9f4cbde5a3bee7b54d6448dfce58b238
ToppCellPosterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Htra1)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

AASS PRSS56 ERMAP GRIN2C

1.44e-05867644263673abf183f2e04f1a2bf37e365a25b8cb0b4
ToppCellPosterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Htra1)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

AASS PRSS56 ERMAP GRIN2C

1.44e-0586764c6c0e8e562ffc705e0cd3f503a9e43ca2669e9b0
ToppCellmetastatic_Brain-Endothelial_cells-Stalk-like_ECs|metastatic_Brain / Location, Cell class and cell subclass

SHROOM4 CNTNAP3B NPR1 PI16 ROBO3

1.62e-05185765ad52970e88e8947ef256095bd4b40229b912d58a
ToppCellmetastatic_Lymph_Node-Endothelial_cells-Tumor_ECs|metastatic_Lymph_Node / Location, Cell class and cell subclass

SHROOM4 CNTNAP3B NPR1 AASS CNTNAP3

1.71e-051877652713f526f86911fbbf6c7a3e69230f2e6bde31c3
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_venous_(13)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CNTNAP3B NPR1 JPH4 PI16 CNTNAP3

1.99e-0519376584d1c1b7d3a1cb80f175527e3c89a2c3da7657f7
ToppCellFrontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Gja1)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

AASS PRSS56 BTBD17 GRIN2C

2.31e-0597764031bc124739541b0b2591e1b6ef41f12adfd5c18
ToppCellFrontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Gja1)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

AASS PRSS56 BTBD17 GRIN2C

2.31e-05977640cd19f619f10a35d3107518aa83c0eda0572930a
ToppCellFrontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Gja1)--|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

AASS PRSS56 BTBD17 GRIN2C

2.31e-059776433330ac2de9e49d78b478f175068999235c9af25
ToppCellPosterior_cortex-Macroglia-ASTROCYTE|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

AASS BTBD17 GRIN2C PRDX6

4.07e-051127641c0bcc6c972c50a9d950cd56b65efb8d778ec25a
ToppCellPosterior_cortex-Macroglia-ASTROCYTE-Gja1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

AASS BTBD17 GRIN2C PRDX6

4.07e-05112764e30cd0b7b755c63081bbeed4e1a884b6640d34f8
ToppCellStriatum-Macroglia-ASTROCYTE|Striatum / BrainAtlas - Mouse McCarroll V32

AASS PRSS56 GRIN2C ALPK1

5.15e-051197640583387cc4497cf991fa42a81f2f66d9c6b774eb
ToppCellStriatum-Macroglia-ASTROCYTE-Gja1|Striatum / BrainAtlas - Mouse McCarroll V32

AASS PRSS56 GRIN2C ALPK1

5.15e-05119764d47880ef1cff036192c43646a04fa8598dd7e1f4
DrugMetformin hydrochloride [1115-70-4]; Down 200; 24.2uM; HL60; HT_HG-U133A

ZMYND8 ERMAP CCDC85C ALPK1 UAP1L1 GOLGA2 CAPN10

3.89e-061947671858_DN
DrugSulfameter [651-06-9]; Down 200; 14.2uM; HL60; HT_HG-U133A

ENTPD7 CCDC85C RPRD2 SNAPC3 UAP1L1 LRRC41 CAPN10

4.31e-061977672712_DN
DrugAdiphenine hydrochloride [50-42-0]; Down 200; 11.4uM; HL60; HT_HG-U133A

ENTPD7 LMF2 SAFB2 CCDC85C ALPK1 LRRC41 CAPN10

4.76e-062007671872_DN
Drugphenylpropionic acid

NAT2 ERMAP B4GALNT2 GRIN2C MAGEE1 CA8

2.04e-05167766CID000000107
Druggenistein; Down 200; 10uM; HL60; HT_HG-U133A

ZNF142 SAFB2 ALPK1 ENDOG TERT LRRC41

3.96e-051887661176_DN
DrugPregnenolone [145-13-1]; Down 200; 12.6uM; HL60; HT_HG-U133A

LMF2 ERMAP SAFB2 CCDC85C ALPK1 UAP1L1

4.08e-051897662497_DN
DrugFenoterol hydrobromide [1944-12-3]; Down 200; 10.4uM; HL60; HT_HG-U133A

CCDC85C SNAPC3 ENDOG TERT CHAC1 LRRC41

4.45e-051927662378_DN
Drug17-AAG; Down 200; 1uM; HL60; HT_HG-U133A

LMF2 SAFB2 ADCK2 ENDOG TERT CHAC1

4.45e-051927666185_DN
DrugLY 294002; Down 200; 10uM; MCF7; HT_HG-U133A

SAFB2 ADCK2 UAP1L1 CHAC1 LRRC41 CAPN10

4.72e-051947665599_DN
DrugDihydroergocristine mesylate [24730-10-7]; Up 200; 5.6uM; MCF7; HT_HG-U133A

NPR1 AATK ZMYND8 KCNK12 ALPK1 CHAC1

4.86e-051957662895_UP
DrugTiapride hydrochloride [51012-33-0]; Down 200; 11uM; MCF7; HT_HG-U133A

FBXO38 KCNK12 SLC35E3 ALPK1 TIGD6 RUSC2

4.86e-051957664686_DN
DrugRamipril [87333-19-5]; Up 200; 9.6uM; PC3; HT_HG-U133A

PIK3CB AASS SAFB2 ADCK2 RUSC2 SEMA4C

4.86e-051957667144_UP
DrugPancuronium bromide [15500-66-0]; Down 200; 5.4uM; PC3; HT_HG-U133A

AATK ERMAP ALPK1 UAP1L1 GOLGA2 TIGD6

5.00e-051967664570_DN
Drug5152487; Down 200; 10uM; MCF7; HT_HG-U133A_EA

LMF2 ZMYND8 ERMAP SNAPC3 GOLGA2 LRRC41

5.00e-05196766896_DN
DrugDiphemanil methylsulfate [62-97-5]; Down 200; 10.2uM; PC3; HT_HG-U133A

AATK CYP2R1 ERMAP SAFB2 ALPK1 GOLGA2

5.00e-051967664591_DN
DrugNortriptyline hydrochloride [894-71-3]; Down 200; 13.4uM; MCF7; HT_HG-U133A

ZMYND8 SAFB2 RPRD2 ALPK1 SNAPC3 LRRC41

5.00e-051967666003_DN
DrugRiboflavine [83-88-5]; Down 200; 10.6uM; PC3; HT_HG-U133A

AATK PIK3CB CCDC85C SNAPC3 GOLGA2 RUSC2

5.14e-051977664485_DN
DrugDoxazosin mesylate [77883-43-3]; Down 200; 7.4uM; MCF7; HT_HG-U133A

CYP2R1 ZMYND8 ERMAP UAP1L1 LRRC41 SEMA4C

5.14e-051977664988_DN
DrugSeneciphylline [480-81-9]; Up 200; 12uM; MCF7; HT_HG-U133A

NPR1 AASS ZFR2 ZIM2 GRIN2C TERT

5.14e-051977664822_UP
DrugEpivincamine [6835-99-0]; Down 200; 11.2uM; MCF7; HT_HG-U133A

LMF2 CYP2R1 ZMYND8 ALPK1 LRRC41 CAPN10

5.29e-051987666838_DN
DrugSertaconazole nitrate [99592-39-9]; Up 200; 8uM; HL60; HT_HG-U133A

ENTPD7 NPR1 KCNK12 GRIN2C TERT SEMA4C

5.59e-052007666128_UP
DrugPropafenone hydrochloride [34183-22-7]; Up 200; 10.6uM; HL60; HG-U133A

ZNF142 LMF2 ZMYND8 TERT LRRC41 CAPN10

5.59e-052007661722_UP
Diseaseautosomal recessive intellectual developmental disorder (implicated_via_orthology)

CNTNAP3B CNTNAP3

1.72e-048742DOID:0060308 (implicated_via_orthology)
DiseaseIntellectual Disability

SHROOM4 ZNF142 AASS BRWD3 CAPN10 CA8

9.08e-04447746C3714756
Diseasediabetes mellitus (is_implicated_in)

NAT2 CYP11B2

2.41e-0329742DOID:9351 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
WGHNKERGRRGENLF

PI16

76

Q6UXB8
HTERFLRQAFGDDWG

ADCK2

181

Q7Z695
WNRAGHLLFGELRRG

CNTNAP3

401

Q9BZ76
RGAWAHSRAALDRLE

BARD1

31

Q99728
AAHGRSRRQGSRFLW

B4GALNT2

56

Q8NHY0
RRIAHGADAVAARWD

ADGRA3

691

Q8IWK6
DHRGVRVVAFGQWAG

AASS

141

Q9UDR5
SGHDAGRRVTWNVLF

BTBD17

346

A6NE02
FNDIGQGWRLRHFVS

GUSBP11

86

Q6P575
RDQAWVDAQRRGYHG

EAPP

146

Q56P03
QEWAEGRGRHINSAF

ACOT12

271

Q8WYK0
LWNGSAFAALHRGRP

BRWD3

116

Q6RI45
RLHAADWAGRARALV

CAPN10

386

Q9HC96
GDFVAALHRRLGWER

NPR1

166

P16066
LRRGGRRNWTHSDAF

ALPK1

531

Q96QP1
QAVDRGDWARALHLF

NOXA1

16

Q86UR1
LFGVWAHNGEVRTAR

PCDHB2

616

Q9Y5E7
LFGVWAHNGEGRTAR

PCDHB18P

561

Q96TA0
SRRKAGHQFGVTWRA

PTCD3

226

Q96EY7
HARESAVWAFLRGLG

MAGEE1

851

Q9HCI5
RQEGVRQAHGSWFRL

ENTPD7

531

Q9NQZ7
NGLRYEGEWLGNRRH

JPH4

301

Q96JJ6
RHDNTGNRAGWFLDR

LOXHD1

886

Q8IVV2
LAREWQRFGRHAAGA

CCDC85C

101

A6NKD9
RNRGKGWRATRLFHD

DCAF4L1

256

Q3SXM0
RWGATLRNFSAAHGV

KCNK12

71

Q9HB15
HRLKFLGFARRNWGN

GDAP1

256

Q8TB36
RLVGDRNEWHGRFLA

GOLGA2

891

Q08379
AAAWYRPAGRRDVAH

ADCYAP1

71

P18509
HVVEDSWRSGGFRNL

FBXO38

281

Q6PIJ6
FNATFWRHVARAGRA

GAL3ST3

301

Q96A11
FTASNGWLDRFRRRH

CENPB

116

P07199
NSRYGRGWVDHRRLA

CYP2R1

126

Q6VVX0
RFHWGRENQRGSEHT

CA8

116

P35219
SRRFWQGDTFHRGSD

CHAC1

61

Q9BUX1
DHGAFPQALRRWLGS

BCAS4

141

Q8TDM0
ARRFDHGRELAAHWA

FIZ1

206

Q96SL8
FDHIVRRNRGGWCLQ

NAT2

56

P11245
QRWLDIRGSGRNFHH

CYP11B2

426

P19099
GQVDARFFGQHDRAW

ZMYND8

301

Q9ULU4
NRGHGREASRVGWFD

RPRD2

1116

Q5VT52
KRAAWLLRGRGVFHN

NEURL4

1211

Q96JN8
WNRAGHLLFGELQRG

CNTNAP3B

401

Q96NU0
FRAWVRAGLGGRHVA

PRSS56

521

P0CW18
RAFGALVWIRGDQHA

NYNRIN

161

Q9P2P1
FGVWAHNGEVRTARL

PCDHB8

616

Q9UN66
ANSGWRRARLHFVAV

ERMAP

226

Q96PL5
LRRHGASWQARDLGG

FANK1

196

Q8TC84
WGHLFGSRKAQREAR

RUSC2

1386

Q8N2Y8
VGWLNRFRDRHGIAL

TIGD6

121

Q17RP2
WARVRFRNHGELSHE

FER1L5

946

A0AVI2
RLWTGAHRLFGAVEH

LMF2

431

Q9BU23
RGAFGHLRLFQNWLD

LRRC41

761

Q15345
EVGARRAAQRGHWRS

AATK

666

Q6ZMQ8
GFDRGHLAAAANHRW

ENDOG

136

Q14249
GRIRFHDFLGDSWGI

PRDX6

21

P30041
RAWGQHRRELFSKGD

SHROOM4

1071

Q9ULL8
WSLARDRGGNQYLRH

MYCBP2

2656

O75592
GNRRIGQFLFWHLRS

PIK3CB

666

P42338
SNLAHARWTFGGRDL

SEMA4C

581

Q9C0C4
AFHVGAFGELWRGRL

SNAPC3

41

Q92966
GEGARTHWRALLRAE

B3GNT9

171

Q6UX72
AFTGLHGRRRREYWQ

VNN2

386

O95498
ALRHARWFQARASGL

ZFR2

771

Q9UPR6
ASFLAFRGLHWGLRR

TLCD2

11

A6NGC4
RFHLNRSAAGWARSA

ROBO3

816

Q96MS0
LRAGARFLDAHGAWL

UAP1L1

436

Q3KQV9
ASREHARWQGGERGL

SAFB2

871

Q14151
VHSFSGDRDWDRRGR

ZIM2

31

Q9NZV7
WDHQVRRDVAGARGA

nan

171

Q8N9P0
QCGKRFRWGSDLARH

ZNF213

321

O14771
NVCHRAFRWAAGLRH

ZNF142

1596

P52746
DRVRGHWRIAAGLLF

SLC35E3

6

Q7Z769
GLWGSRHNERRFLRN

TERT

476

O14746
LDWQARGRGELVTHF

TANGO2

81

Q6ICL3
ALRARAAGLTAHWGR

NDUFV2

6

P19404
ARREALLHAAWARGS

GRIN2C

1061

Q14957