Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	TPR-like_helical_dom	RMDN3 SMG5 OGT ZFC3H1 ANAPC5 MTOR	1.68e-05	233	44	6	IPR011990
Domain	Laminin_G_1	SLIT2 EYS	2.94e-04	11	44	2	PF00054
Domain	Zinc_finger_PHD-type_CS	PYGO2 PHF24 NFX1	4.81e-04	65	44	3	IPR019786
Domain	Znf_PHD-finger	KMT2C PYGO2 NFX1	8.51e-04	79	44	3	IPR019787
Domain	RHO	RHOBTB1 RHOBTB2	1.00e-03	20	44	2	PS51420
Domain	Znf_PHD	KMT2C PYGO2 PHF24	1.28e-03	91	44	3	IPR001965
Domain	-	RMDN3 OGT ANAPC5 MTOR	1.41e-03	207	44	4	1.25.40.10
Domain	ZF_PHD_2	KMT2C PYGO2 PHF24	1.45e-03	95	44	3	PS50016
Domain	ZF_PHD_1	KMT2C PYGO2 PHF24	1.50e-03	96	44	3	PS01359
Domain	hEGF	SLIT2 EYS	1.97e-03	28	44	2	PF12661
Domain	LAM_G_DOMAIN	SLIT2 EYS	3.61e-03	38	44	2	PS50025
Domain	ARM-like	TMCO6 MTOR STAG2 APC2	3.68e-03	270	44	4	IPR011989
Domain	Laminin_G_2	SLIT2 EYS	4.00e-03	40	44	2	PF02210
Domain	ARM	TMCO6 APC2	4.00e-03	40	44	2	SM00185
Domain	LamG	SLIT2 EYS	4.82e-03	44	44	2	SM00282
Domain	Znf_FYVE_PHD	KMT2C PYGO2 PHF24	5.00e-03	147	44	3	IPR011011
Domain	TPR-contain_dom	OGT ZFC3H1 ANAPC5	5.28e-03	150	44	3	IPR013026
Domain	Armadillo	TMCO6 APC2	5.48e-03	47	44	2	IPR000225
Domain	TPR_REGION	OGT ZFC3H1 ANAPC5	6.88e-03	165	44	3	PS50293
Domain	TPR	OGT ZFC3H1 ANAPC5	6.88e-03	165	44	3	PS50005
Domain	-	MSH6 DHX32 NLRP14 RHOBTB1 DNAH14 RHOBTB2	7.70e-03	746	44	6	3.40.50.300
Domain	ARM-type_fold	TMCO6 MTOR STAG2 APC2	8.18e-03	339	44	4	IPR016024
Domain	Laminin_G	SLIT2 EYS	8.25e-03	58	44	2	IPR001791
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	DIP2C ANKRD28 KMT2C SMG5 THSD7A RHOBTB2	3.94e-07	225	44	6	12168954
Pubmed	Photoreceptor Cell-Derived CAPN5 Regulates Retinal Pigment Epithelium Cell Proliferation Through Direct Regulation of SLIT2 Cleavage.	SLIT2 CAPN5	1.56e-06	2	44	2	29610848
Pubmed	The Dictyostelium discoideum family of Rho-related proteins.	RHOBTB1 RHOBTB2	4.69e-06	3	44	2	11222756
Pubmed	Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis.	RHOBTB1 RHOBTB2	4.69e-06	3	44	2	27314390
Pubmed	Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse.	RHOBTB1 RHOBTB2	4.69e-06	3	44	2	12426103
Pubmed	UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target.	MSH6 MTOR BUB1B	7.49e-06	30	44	3	32867711
Pubmed	Gax suppresses chemerin/CMKLR1-induced preadipocyte biofunctions through the inhibition of Akt/mTOR and ERK signaling pathways.	CMKLR1 MTOR	9.37e-06	4	44	2	28326537
Pubmed	Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism.	RHOBTB1 RHOBTB2	1.56e-05	5	44	2	18835386
Pubmed	Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation.	MTOR RBL2	1.56e-05	5	44	2	19703998
Pubmed	Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling.	WSB2 CSF3R	2.34e-05	6	44	2	17001306
Pubmed	MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein.	RHOBTB1 RHOBTB2	2.34e-05	6	44	2	22709582
Pubmed	Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain.	RHOBTB1 RHOBTB2	4.36e-05	8	44	2	24923387
Pubmed	The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids.	ANKRD28 MTOR	6.99e-05	10	44	2	27244671
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	RMDN3 KMT2C MSH6 OGT ZFC3H1 NDUFA8 ANAPC5 STAG2 NFX1	8.97e-05	1497	44	9	31527615
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	RMDN3 ANKRD28 MSH6 DHX32 OGT MTOR	1.10e-04	606	44	6	36538041
Pubmed	mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.	MTOR RUBCN	1.21e-04	13	44	2	25533187
Pubmed	Characterization of vertebrate cohesin complexes and their regulation in prophase.	ANAPC5 STAG2	1.41e-04	14	44	2	11076961
Pubmed	APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.	ANAPC5 BUB1B	1.63e-04	15	44	2	23007861
Pubmed	Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis.	ANAPC5 BUB1B	2.10e-04	17	44	2	23160376
Pubmed	Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads.	ANAPC5 STAG2	2.10e-04	17	44	2	21043528
Pubmed	Mechanism of APC/CCDC20 activation by mitotic phosphorylation.	ANAPC5 BUB1B	2.10e-04	17	44	2	27114510
Pubmed	BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner.	ANAPC5 BUB1B	2.36e-04	18	44	2	22193957
Pubmed	The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit.	ANAPC5 BUB1B	2.36e-04	18	44	2	14593737
Pubmed	Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2.	ANAPC5 BUB1B	2.36e-04	18	44	2	11535616
Pubmed	APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box.	ANAPC5 BUB1B	2.93e-04	20	44	2	11742988
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	KMT2C OGT	2.93e-04	20	44	2	29785026
Pubmed	Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.	RMDN3 LTBR RHOBTB2 TMEM151B	3.42e-04	263	44	4	19773279
Pubmed	Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis.	STAG2 BUB1B	3.56e-04	22	44	2	21690297
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	RMDN3 ANKRD28 SMG5 OGT RBL2 STAG2	6.99e-04	857	44	6	25609649
Pubmed	NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.	APC2 NFX1	7.57e-04	32	44	2	17267499
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	PEX7 NLRP14 THSD7A RNF19A	7.66e-04	326	44	4	17015433
Pubmed	Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.	MSH6 RHOBTB2	8.06e-04	33	44	2	19714462
Pubmed	Lynch Syndrome	MSH6 BUB1B	8.06e-04	33	44	2	20301390
Pubmed	Paradoxical mitotic exit induced by a small molecule inhibitor of APC/CCdc20.	ANAPC5 BUB1B	8.06e-04	33	44	2	32152539
Pubmed	Ubiquitin chain elongation requires E3-dependent tracking of the emerging conjugate.	ANAPC5 BUB1B	8.06e-04	33	44	2	25306918
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	ANKRD28 MSH6 ANAPC5	9.69e-04	153	44	3	26365490
Pubmed	Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation.	ANAPC5 BUB1B	1.01e-03	37	44	2	26811472
Pubmed	Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.	SMG5 ZFC3H1 ANAPC5	1.12e-03	161	44	3	32572027
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	SLIT2 RMDN3 NDUFA8 ANAPC5 MTOR STAG2	1.14e-03	942	44	6	31073040
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	KMT2C MSH6 OGT	1.25e-03	167	44	3	20362541
GeneFamily	PHD finger proteins	KMT2C PYGO2 PHF24 NFX1	1.07e-05	90	28	4	88
GeneFamily	Rho family GTPases	RHOBTB1 RHOBTB2	4.32e-04	20	28	2	390
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#4	SLIT2 WSB2 KMT2C HERC3 THSD7A RBL2 RUBCN TMEM151B APC2	1.39e-05	721	44	9	Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_2500_K4
CoexpressionAtlas	FacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_2500_k-means-cluster#5	SLIT2 WSB2 KMT2C HERC3 THSD7A RBL2 RUBCN TMEM151B APC2	1.41e-05	722	44	9	Facebase_RNAseq_e9.5_Facial Mesenchyne_2500_K5
CoexpressionAtlas	FacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_2500_k-means-cluster#3	SLIT2 WSB2 KMT2C HERC3 THSD7A RBL2 RUBCN TMEM151B APC2	1.54e-05	730	44	9	Facebase_RNAseq_e8.5_Paraxial Mesoderm_2500_K3
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#5	SLIT2 WSB2 KMT2C HERC3 THSD7A RBL2 RUBCN TMEM151B APC2	1.77e-05	743	44	9	Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_2500_K5
CoexpressionAtlas	FacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#2	SLIT2 WSB2 KMT2C HERC3 THSD7A RBL2 RUBCN TMEM151B APC2	1.85e-05	747	44	9	Facebase_RNAseq_e9.5_Maxillary Arch_2500_K2
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#2	SLIT2 WSB2 KMT2C HERC3 THSD7A RBL2 RUBCN TMEM151B APC2	1.85e-05	747	44	9	Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_2500_K2
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k-means-cluster#3_top-relative-expression-ranked_100	PRSS35 TMEM255A	2.51e-05	4	44	2	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k3_100
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_2500_k-means-cluster#3	SLIT2 WSB2 HERC3 RBL2 RUBCN TMEM151B APC2	3.42e-05	447	44	7	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_2500_K3
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#5	SLIT2 WSB2 HERC3 THSD7A RBL2 RUBCN TMEM151B APC2	5.38e-05	658	44	8	Facebase_RNAseq_ratio_e10.5_MandibularArch_vs_MaxillaryArch_2500_K5
CoexpressionAtlas	FacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#5	SLIT2 WSB2 DHX32 HERC3 THSD7A RBL2 TMEM151B APC2	1.13e-04	732	44	8	Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_2500_K5
CoexpressionAtlas	FacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_2500_k-means-cluster#2	SLIT2 WSB2 DHX32 HERC3 RBL2 TMEM151B APC2	3.79e-04	659	44	7	Facebase_RNAseq_e10.5_Olfactory Pit_2500_K2
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	KMT2C OGT ZFC3H1 THSD7A RNF19A	1.45e-06	197	44	5	57ebd552f10d6278623b52a3d484d4b91ae1d028
Disease	developmental and epileptic encephalopathy 64 (implicated_via_orthology)	RHOBTB1 RHOBTB2	2.17e-06	2	44	2	DOID:0070375 (implicated_via_orthology)
Disease	leukemia	MSH6 CSF3R STAG2	7.69e-05	55	44	3	C0023418
Disease	mismatch repair cancer syndrome (is_implicated_in)	MSH6 ASTE1	1.42e-04	12	44	2	DOID:0112182 (is_implicated_in)
Disease	Malignant neoplasm of breast	DIP2C MSH6 DHX32 NLRP14 NDUFA8 ANAPC5 MTOR APC2	1.66e-04	1074	44	8	C0006142
Disease	Benign neoplasm of bladder	MTOR STAG2	2.25e-04	15	44	2	C0154017
Disease	Neoplasm of uncertain or unknown behavior of bladder	MTOR STAG2	2.25e-04	15	44	2	C0496930
Disease	Carcinoma in situ of bladder	MTOR STAG2	2.25e-04	15	44	2	C0154091
Disease	Carcinoma of bladder	MTOR STAG2	3.27e-04	18	44	2	C0699885
Disease	Malaria	LTBR CR1	4.06e-04	20	44	2	C0024530
Disease	Intellectual Disability	KMT2C MTOR STAG2 RHOBTB2 APC2	5.21e-04	447	44	5	C3714756
Disease	insular cortex volume measurement	SLIT2 THSD7A	5.39e-04	23	44	2	EFO_0010309
Disease	Lynch syndrome (is_implicated_in)	MSH6 ASTE1	5.87e-04	24	44	2	DOID:3883 (is_implicated_in)
Disease	Global developmental delay	STAG2 RHOBTB2 APC2	1.04e-03	133	44	3	C0557874
Disease	ovarian neoplasm	MSH6 MTOR RBL2	1.06e-03	134	44	3	C0919267
Disease	Malignant neoplasm of ovary	MSH6 MTOR RBL2	1.13e-03	137	44	3	C1140680
Disease	Bladder Neoplasm	KMT2C MTOR STAG2	1.20e-03	140	44	3	C0005695
Disease	Malignant neoplasm of urinary bladder	KMT2C MTOR STAG2	1.23e-03	141	44	3	C0005684
Disease	response to radiation, prostate carcinoma, erectile dysfunction	CMKLR1 NFX1	1.40e-03	37	44	2	EFO_0001663, EFO_0004234, GO_0009314

Protein segments in the cluster

Peptide	Gene	Start	Entry
GCIVWHQYINCFTLQ	BUB1B	831	O60566
HWACYNGHETCVELL	ANKRD28	761	O15084
QLIYCHSNSRNEFWC	CAPN5	146	O15484
PQWCAEYCLSIHYQH	DHX32	96	Q7L7V1
LDTAHIFCQWQSCLQ	ASTE1	536	Q2TB18
GNDLHWLACALYVAC	RBL2	81	Q08999
DHVCLQHCLSWLYVL	ANAPC5	336	Q9UJX4
SSQWHHNCLICDNCY	KMT2C	446	Q8NEZ4
LHLSYQCVCLSDWEG	EYS	751	Q5T1H1
CFVEHNWFHLIGITC	HERC3	781	Q15034
AHQAEILSCDWCKYN	PEX7	196	O00628
VWSCQSCYHVFHLNC	NFX1	371	Q12986
QWLCAPLCNHYAIND	MSH6	776	P52701
QDAILCEASCQKWFH	PYGO2	341	Q9BRQ0
LHVLEQIRAYCETCW	APC2	371	O95996
IWSQLDHYCKEVNCS	CR1	1896	P17927
WCLCSVYSGHQSILI	DIP2C	1191	Q9Y2E4
HLNHTQAFLSCCLNW	CSF3R	91	Q99062
CSLCQWVIALNNYHE	DNAH14	2446	Q0VDD8
IYIIQGHWQCHNCQT	IQCF2	126	Q8IXL9
VAELWLQHSLQYHCL	RUBCN	121	Q92622
WTCIDYTGQQLFRHC	NDUFA8	86	P51970
YCNLAHCLQIVCDWT	OGT	466	O15294
QATSHENLCQCYIGW	MTOR	2531	P42345
CHLWYAVLCGQLAEH	RMDN3	321	Q96TC7
SHYQLELQCCIDWTH	SMG5	131	Q9UPR3
VRSCNEHPCTVYHWQ	THSD7A	686	Q9UPZ6
EVVPCHSDCNQYLWV	THSD7A	1086	Q9UPZ6
VYLVECWHCQARHEL	TMEM151B	126	Q8IW70
SCQDIIHLYHLLWSA	TMEM255A	211	Q5JRV8
QLADWCLHHICTNYN	RHOBTB2	626	Q9BYZ6
CWDENQYLLCPHSAV	THNSL2	381	Q86YJ6
QLAAWCLHHICTNYN	RHOBTB1	611	O94844
TGWSCHYCDNINLLL	PHF24	181	Q9UPV7
LCWCPYHTLNLLELH	CMKLR1	271	Q99788
CYHCKQIWHPNQTCD	RNF19A	251	Q9NV58
IHALQCTHYVILWQL	STAG2	731	Q8N3U4
YAQICLWIHGNDANC	PRSS35	396	Q8N3Z0
AVEFAWCLHYIICSQ	TMCO6	256	Q96DC7
LHSNNLYCDCHLAWL	SLIT2	206	O94813
HWNYLTICQLCRPCD	LTBR	91	P36941
CSFQQWYHLPCRHIL	ZSWIM3	551	Q96MP5
QVLSGHLQWVYCCSI	WSB2	191	Q9NYS7
NHQVPYLWLIYCLCH	ZFC3H1	1741	O60293
CWQDLCSVLHTNEHL	NLRP14	661	Q86W24