Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	WW	PLEKHA5 PIN1 PIN1P1	9.24e-05	47	35	3	PF00397
Domain	WW	PLEKHA5 PIN1 PIN1P1	9.84e-05	48	35	3	SM00456
Domain	WW_DOMAIN_2	PLEKHA5 PIN1 PIN1P1	1.18e-04	51	35	3	PS50020
Domain	WW_DOMAIN_1	PLEKHA5 PIN1 PIN1P1	1.18e-04	51	35	3	PS01159
Domain	WW_dom	PLEKHA5 PIN1 PIN1P1	1.25e-04	52	35	3	IPR001202
Domain	DnaJ	DNAJC13 DNAJC6	3.65e-03	48	35	2	PF00226
Domain	DnaJ	DNAJC13 DNAJC6	3.80e-03	49	35	2	SM00271
Domain	DNAJ_1	DNAJC13 DNAJC6	3.80e-03	49	35	2	PS00636
Domain	DNAJ_2	DNAJC13 DNAJC6	3.80e-03	49	35	2	PS50076
Domain	-	DNAJC13 DNAJC6	3.80e-03	49	35	2	1.10.287.110
Domain	DnaJ_domain	DNAJC13 DNAJC6	4.11e-03	51	35	2	IPR001623
Domain	TPR_8	PRPF6 CDC23	4.43e-03	53	35	2	PF13181
Domain	TPR_1	PRPF6 CDC23	1.23e-02	90	35	2	PF00515
Domain	TPR_1	PRPF6 CDC23	1.23e-02	90	35	2	IPR001440
Pubmed	Dennd3 functions as a guanine nucleotide exchange factor for small GTPase Rab12 in mouse embryonic fibroblasts.	RAB12 DENND3	1.04e-06	2	36	2	24719330
Pubmed	Prolyl-peptidyl isomerase, Pin1, phosphorylation is compromised in association with the expression of the HFE polymorphic allele, H63D.	HFE PIN1	1.04e-06	2	36	2	20060900
Pubmed	Regulation of DENND3, the exchange factor for the small GTPase Rab12 through an intramolecular interaction.	RAB12 DENND3	1.04e-06	2	36	2	28249939
Pubmed	The human PIN1 peptidyl-prolyl cis/trans isomerase gene maps to human chromosome 19p13 and the closely related PIN1L gene to 1p31.	PIN1 PIN1P1	1.04e-06	2	36	2	9299231
Pubmed	A PH-like domain of the Rab12 guanine nucleotide exchange factor DENND3 binds actin and is required for autophagy.	RAB12 DENND3	1.04e-06	2	36	2	29352104
Pubmed	Small GTPase Rab12 regulates constitutive degradation of transferrin receptor.	RAB12 DENND3	3.12e-06	3	36	2	21718402
Pubmed	DNAJ mutations are rare in Chinese Parkinson's disease patients and controls.	DNAJC13 DNAJC6	3.12e-06	3	36	2	24126164
Pubmed	PIN1P1 is activated by CREB1 and promotes gastric cancer progression via interacting with YBX1 and upregulating PIN1.	PIN1 PIN1P1	6.24e-06	4	36	2	37929660
Pubmed	Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy.	RAB12 DENND3	6.24e-06	4	36	2	25925668
Pubmed	Characterization of vertebrate cohesin complexes and their regulation in prophase.	CDC23 RAD21	9.41e-05	14	36	2	11076961
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CDC37 PLEKHA5 NAA35 PRPF6 DNAJC13 DNAJC6 ESF1 RAD21	1.14e-04	1487	36	8	33957083
Pubmed	Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads.	CDC23 RAD21	1.40e-04	17	36	2	21043528
Pubmed	Proximity Labeling Reveals Spatial Regulation of the Anaphase-Promoting Complex/Cyclosome by a Microtubule Adaptor.	PLEKHA5 CDC23	2.38e-04	22	36	2	35952650
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CDC37 PLEKHA5 NAA35 PRPF6 DNAJC13 PIN1 ESF1	4.12e-04	1353	36	7	29467282
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CDC37 PRPF6 DNAJC13 IDH3A RAD21	4.82e-04	638	36	5	33239621
Pubmed	Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome.	CDC37 RAD21	5.07e-04	32	36	2	20056645
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	CDC37 PLEKHA5 GRIPAP1 SPTB	5.12e-04	360	36	4	33111431
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	CDC37 PRPF6 PIN1 ESF1 CDC23 RAD21	5.58e-04	1014	36	6	32416067
Pubmed	DEPDC1B coordinates de-adhesion events and cell-cycle progression at mitosis.	RGS3 CDC23	6.07e-04	35	36	2	25458010
Pubmed	Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.	CDC37 PLEKHA5 RAD21	6.10e-04	160	36	3	31678930
Pubmed	Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.	RAB12 DENND3	6.78e-04	37	36	2	20937701
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	PLEKHA5 DNAJC13 IDH3A CDC23	8.94e-04	418	36	4	34709266
Cytoband	19q13.11	ZNF302 ZNF181	5.79e-04	45	36	2	19q13.11
Cytoband	Ensembl 112 genes in cytogenetic band chr8q24	WDR97 DENND3 RAD21	2.71e-03	355	36	3	chr8q24
Cytoband	8q24.3	WDR97 DENND3	3.58e-03	113	36	2	8q24.3
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJC13 DNAJC6	2.07e-03	49	25	2	584
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	TSHZ1 ZNF302 ZNF726 ZNF181	1.61e-02	718	25	4	28
GeneFamily	Fibronectin type III domain containing	CHL1 MYBPC2	2.04e-02	160	25	2	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	CHL1 MYBPC2	2.07e-02	161	25	2	593
Disease	Parkinson's disease (is_implicated_in)	DNAJC13 DNAJC6 GSTO1 DDC	1.57e-06	76	33	4	DOID:14330 (is_implicated_in)
Disease	Stuttering	PLEKHA5 DENND3 ESF1	5.47e-04	143	33	3	HP_0025268
Disease	Parkinson's disease (implicated_via_orthology)	ATP13A5 DNAJC6 DDC	7.17e-04	157	33	3	DOID:14330 (implicated_via_orthology)
Disease	cerebellar volume measurement	HFE DENND3	1.55e-03	52	33	2	EFO_0020864
Disease	total iron binding capacity	HFE DNAJC13	3.45e-03	78	33	2	EFO_0006334
Disease	Parkinson Disease	HFE DDC	4.09e-03	85	33	2	C0030567
Disease	serum iron measurement	HFE ATP13A5	4.18e-03	86	33	2	EFO_0006332
Disease	Retinitis Pigmentosa	PRPF6 IDH3A	6.05e-03	104	33	2	C0035334

Protein segments in the cluster

Peptide	Gene	Start	Entry
KEMLKFLSLPDTWMK	CDC23	216	Q9UJX2
DPLDLKMFEGTAWKM	ATP13A5	546	Q4VNC0
TVMMDWLGKMLELPK	DDC	116	P20711
LMVKEMWAGKKLADD	DENND3	806	A2RUS2
KKETFDDLPKWMKMI	RAB12	126	Q6IQ22
PTKKLMMWKETGGVE	RAD21	356	O60216
MMKSFKPTSEEALKW	RGS3	1056	P49796
DMKLWEKGSIKMPFI	RECK	381	O95980
VMSAGEMDKWKGIEP	NXF3	261	Q9H4D5
KEMIIKWEPLKSMEQ	CHL1	726	O00533
TPKLKLWMAAMKEDP	GSTO1	196	P78417
LWMDKEKEESMKETL	DHRS4L1	226	P0CG22
GKENDMEMEIKWVPG	ESF1	596	Q9H501
MEMEIKWVPGLKESA	ESF1	601	Q9H501
MADEEKLPPGWEKRM	PIN1	1	Q13526
MADEEKLPPGWEKRM	PIN1P1	1	O15428
TMKWLKDKQPMDAKE	HFE	236	Q30201
GKWMIPSEAKESMDK	IDH3A	76	P50213
KLEEMRKKEKSMPWN	CDC37	101	Q16543
MAKEMDPEKLKILEW	DNAJC6	811	O75061
WKKEVEKKPPMMSID	DNAJC13	1286	O75165
TEKMKEIVGWMPLMA	FBXO24	536	O75426
PMPLAEVELKWEMEK	GRIPAP1	186	Q4V328
WMGLPDLEVKDWMQK	OSGIN1	146	Q9UJX0
EDFPKLWMMKGQIEE	PRPF6	706	O94906
VELKKEVEMKGVWSM	ABHD10	191	Q9NUJ1
SPWGMKKVLLEMEDQ	TRAF3IP3	261	Q9Y228
DSGWELSMPEKMEKS	NAA35	11	Q5VZE5
KEMMTWVQGPDLDSK	WDR97	1326	A6NE52
EKEKWLAEMEMPDTL	SPTB	866	P11277
KTDLMKAPMVIMDWE	PRSS55	206	Q6UWB4
LEKEKEPWNMKRDEM	ZNF726	56	A6NNF4
DTGKEMELWMKAMLD	PLEKHA5	251	Q9HAU0
WSKPRKRSLMEMEGK	TSHZ1	286	Q6ZSZ6
LLEDGKEPWMMEKKL	ZNF181	56	Q2M3W8
KEPWMMEKKLSKGMI	ZNF181	61	Q2M3W8
MEKKLSKGMIPDWES	ZNF181	66	Q2M3W8
LEDGKEPWMMEKKLS	ZNF302	56	Q9NR11
WMKNKMEIREDPKFL	MYBPC2	1081	Q14324