Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

NPFFR2 GPR143 CHRNA6 TNFRSF10D OR13C7 EDAR GPR157 GNRHR OR13C6P GPR160 CHRNB2 CD300LB NRP2

7.39e-0613534613GO:0004888
GeneOntologyMolecularFunctiontransmembrane transporter activity

TMEM38A CACNA1C PEX12 CHRNA6 TMC7 SEC61A1 SLC23A2 ABCA9 SLC29A1 CHRNB2 SCN4A

5.75e-0511804611GO:0022857
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

TMEM38A CACNA1C CHRNA6 TMC7 SEC61A1 SLC23A2 SLC29A1 CHRNB2 SCN4A

6.90e-05793469GO:0015075
GeneOntologyMolecularFunctionmonoatomic ion channel activity

TMEM38A CACNA1C CHRNA6 TMC7 SEC61A1 CHRNB2 SCN4A

7.99e-05459467GO:0005216
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

TMEM38A CACNA1C CHRNA6 SEC61A1 SLC23A2 SLC29A1 CHRNB2 SCN4A

1.22e-04664468GO:0008324
GeneOntologyMolecularFunctiontransporter activity

TMEM38A CACNA1C PEX12 CHRNA6 TMC7 SEC61A1 SLC23A2 ABCA9 SLC29A1 CHRNB2 SCN4A

1.27e-0412894611GO:0005215
GeneOntologyMolecularFunctionmonoatomic cation channel activity

TMEM38A CACNA1C CHRNA6 SEC61A1 CHRNB2 SCN4A

1.29e-04343466GO:0005261
GeneOntologyMolecularFunctionchannel activity

TMEM38A CACNA1C CHRNA6 TMC7 SEC61A1 CHRNB2 SCN4A

1.84e-04525467GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

TMEM38A CACNA1C CHRNA6 TMC7 SEC61A1 CHRNB2 SCN4A

1.86e-04526467GO:0022803
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

TMEM38A CACNA1C SEC61A1 SLC23A2 SLC29A1 SCN4A

6.57e-04465466GO:0046873
GeneOntologyMolecularFunctionacetylcholine-gated monoatomic cation-selective channel activity

CHRNA6 CHRNB2

6.91e-0417462GO:0022848
GeneOntologyMolecularFunctiongated channel activity

TMEM38A CACNA1C CHRNA6 TMC7 CHRNB2

9.93e-04334465GO:0022836
GeneOntologyMolecularFunctionacetylcholine receptor activity

CHRNA6 CHRNB2

1.27e-0323462GO:0015464
GeneOntologyMolecularFunctionprotein transmembrane transporter activity

PEX12 SEC61A1

1.89e-0328462GO:0008320
GeneOntologyMolecularFunctionmacromolecule transmembrane transporter activity

PEX12 SEC61A1

2.78e-0334462GO:0022884
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

TMEM38A CACNA1C SEC61A1 SLC23A2 SLC29A1 SCN4A

3.01e-03627466GO:0022890
GeneOntologyMolecularFunctionG protein-coupled receptor activity

NPFFR2 GPR143 OR13C7 GPR157 GNRHR OR13C6P GPR160

3.85e-03884467GO:0004930
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

TMEM38A CHRNA6 CHRNB2

4.11e-03140463GO:0099094
GeneOntologyMolecularFunctionprotein transporter activity

PEX12 SEC61A1

4.22e-0342462GO:0140318
GeneOntologyMolecularFunctionexcitatory extracellular ligand-gated monoatomic ion channel activity

CHRNA6 CHRNB2

4.41e-0343462GO:0005231
GeneOntologyBiologicalProcessmembrane depolarization

ADCY10 CACNA1C CHRNA6 CHRNB2 SCN4A

6.47e-06121455GO:0051899
DomainNicotinic_acetylcholine_rcpt

CHRNA6 CHRNB2

6.37e-0416442IPR002394
DomainAcetylcholine_rcpt_TM

CHRNA6 CHRNB2

1.33e-0323442IPR027361
Domain-

CHRNA6 CHRNB2

1.33e-03234421.20.120.370
DomainTNFR_NGFR_1

TNFRSF10D EDAR

2.11e-0329442PS00652
DomainTNFR_NGFR_2

TNFRSF10D EDAR

2.11e-0329442PS50050
DomainTNFR/NGFR_Cys_rich_reg

TNFRSF10D EDAR

2.73e-0333442IPR001368
DomainDeath_domain

TNFRSF10D EDAR

3.61e-0338442IPR000488
DomainDEATH_DOMAIN

TNFRSF10D EDAR

3.61e-0338442PS50017
DomainNeurotransmitter_ion_chnl_CS

CHRNA6 CHRNB2

5.04e-0345442IPR018000
DomainNeur_chan_memb

CHRNA6 CHRNB2

5.26e-0346442PF02932
DomainNeur_chan_LBD

CHRNA6 CHRNB2

5.48e-0347442PF02931
DomainNeur_channel

CHRNA6 CHRNB2

5.48e-0347442IPR006201
DomainNeur_chan_lig-bd

CHRNA6 CHRNB2

5.48e-0347442IPR006202
DomainNEUROTR_ION_CHANNEL

CHRNA6 CHRNB2

5.48e-0347442PS00236
DomainNeurotrans-gated_channel_TM

CHRNA6 CHRNB2

5.48e-0347442IPR006029
Domain-

CHRNA6 CHRNB2

5.48e-03474422.70.170.10
DomainChannel_four-helix_dom

CACNA1C SCN4A

7.97e-0357442IPR027359
Domain-

CACNA1C SCN4A

7.97e-03574421.20.120.350
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA6 CHRNB2

2.13e-049352MM15313
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA6 CHRNB2

2.13e-049352M27597
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA6 CHRNB2

3.25e-0411352M883
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA6 CHRNB2

3.89e-0412352MM15312
PathwayREACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA6 CHRNB2

3.89e-0412352M48008
PathwayREACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS

CHRNA6 CHRNB2

5.35e-0414352M757
PathwayREACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS

CHRNA6 CHRNB2

6.16e-0415352MM14704
Pubmed

Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model.

AMPD3 SLC29A1

1.71e-06246237725437
Pubmed

α6β2 nicotinic acetylcholine receptors influence locomotor activity and ethanol consumption.

CHRNA6 CHRNB2

1.71e-06246228457669
Pubmed

Efficient expression of functional (α6β2)2β3 AChRs in Xenopus oocytes from free subunits using slightly modified α6 subunits.

CHRNA6 CHRNB2

5.13e-06346225068303
Pubmed

Expression of functional human α6β2β3* acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers.

CHRNA6 CHRNB2

5.13e-06346220923852
Pubmed

Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice.

CHRNA6 CHRNB2

5.13e-06346212944511
Pubmed

New insights on the regulation of the adenine nucleotide pool of erythrocytes in mouse models.

AMPD3 SLC29A1

5.13e-06346228746349
Pubmed

Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain.

CHRNA6 CHRNB2

1.03e-05446219481067
Pubmed

CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences.

CHRNA6 CHRNB2

1.03e-05446220854418
Pubmed

Lhx2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth.

TNFAIP3 EDAR NRP2

1.15e-053346326952977
Pubmed

Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum.

CHRNA6 CHRNB2

1.71e-05546224607281
Pubmed

Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions.

CHRNA6 CHRNB2

3.58e-05746220231857
Pubmed

Functional interaction between Lypd6 and nicotinic acetylcholine receptors.

CHRNA6 CHRNB2

4.77e-05846227344019
Pubmed

Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

CHRNA6 CHRNB2

6.12e-0594628906617
Pubmed

Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release.

CHRNA6 CHRNB2

6.12e-05946219228980
Pubmed

Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence.

CHRNA6 CHRNB2

7.65e-051046220736995
Pubmed

Differential expression of nicotinic acetylcholine receptor subunits in fetal and neonatal mouse thymus.

CHRNA6 CHRNB2

9.34e-051146212225896
Pubmed

Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission.

CHRNA6 CHRNB2

9.34e-051146229791835
Pubmed

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.

TMEM38A CACNA1C

1.12e-041246219095005
Pubmed

Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human.

OR13C7 OR13C6P

1.12e-041246212906860
Pubmed

Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties.

CHRNA6 CHRNB2

1.54e-041446219059502
Pubmed

Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development.

CHRNA6 CHRNB2

1.54e-041446223213462
Pubmed

Analysis of nicotinic acetylcholine receptor subunits in the cochlea of the mouse.

CHRNA6 CHRNB2

1.78e-04154628838678
Pubmed

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.

CHRNA6 CHRNB2

2.03e-041646219259974
Pubmed

No evidence for association between 19 cholinergic genes and bipolar disorder.

CHRNA6 CHRNB2

2.88e-041946217373692
Pubmed

Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development.

TNFRSF10D EDAR

6.33e-042846238131461
Pubmed

Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program.

CHRNB2 NRP2

8.28e-043246230936179
Pubmed

The TNF and TNF receptor superfamilies: integrating mammalian biology.

TNFRSF10D EDAR

1.23e-033946211239407
Cytoband16p12.3

DNAH3 TMC7

5.40e-043446216p12.3
GeneFamily7TM orphan receptors

GPR143 GPR157 GPR107

1.57e-076373310
GeneFamilyCholinergic receptors nicotinic subunits

CHRNA6 CHRNB2

4.80e-0416372173
GeneFamilyOlfactory receptors, family 13

OR13C7 OR13C6P

1.00e-0323372162
GeneFamilyCD molecules|Tumor necrosis factor receptor superfamily|Death inducing signaling complex

TNFRSF10D EDAR

1.60e-0329372782
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1C CHRNA6 PLEKHH2 GPR157 ABCA9

1.71e-07125455b162a5bfbb8ac5e65e13578fef9de442a9e4fd8b
ToppCell390C-Myeloid-Dendritic-cDC_activated|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CCNG2 CCDC81 MAP3K6 GPR157 NRP2

1.54e-06195455ecf7d9856a5b507ec17c325c9a772dc5a184bc8e
ToppCell390C-Myeloid-Dendritic-cDC_activated|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

CCNG2 CCDC81 MAP3K6 GPR157 NRP2

1.62e-06197455311438418f3d697e54222da111014c887fd815f5
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1C VPS13C CHRNB2 XPOT

2.84e-05174454f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-MAIT_cell|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNFAIP3 GIMAP2 XPOT CRTAM

3.11e-051784540290868dc990878eac5c182fe64968333bc52450
ToppCell10x5'-Lung-Myeloid_Dendritic-migDC|Lung / Manually curated celltypes from each tissue

CHRNA6 CCDC81 GPR157 NRP2

3.25e-05180454e9e8992deb0beeee5548910e4616e7c990763d99
ToppCellmetastatic_Lymph_Node-Fibroblasts-COL14A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

EVC PLEKHH2 SLC23A2 ABCA9

3.69e-051864546259f0f2d5bc863782d09a901d6be2f387d1f074
ToppCell390C-Myeloid-Dendritic-cDC_activated|390C / Donor, Lineage, Cell class and subclass (all cells)

CCNG2 CCDC81 GPR157 NRP2

3.77e-0518745460c2576f31a60f819deb9ec500d1f714b469df4e
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C ABCA9 SLC29A1 STEAP1

4.26e-05193454e5016959f24370579a8770787e96869f264cf7b3
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C PLEKHH2 GPR157 ABCA9

4.35e-05194454e93de9428c986b8943fc169258847c650cfab0e5
ToppCellCOPD-Stromal|COPD / Disease state, Lineage and Cell class

CACNA1C PLEKHH2 ABCA9 STEAP1

4.62e-05197454d5390d86acaa8c39f1da893e8d2271f9ed2951d7
ToppCellCOVID-19-lung-Fibroblast|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1C PLEKHH2 ABCA9 STEAP1

4.71e-051984543ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCellControl-Stromal|Control / Disease state, Lineage and Cell class

CACNA1C PLEKHH2 ABCA9 STEAP1

4.71e-05198454ae726b6b7f0a4107899be4d32ac256ffa0bd8d59
ToppCelldistal-1-Hematologic-EREG+_Dendritic|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

AMPD3 TNFAIP3 ABCA9 CD300LB

4.80e-0519945415249f2f48b1e99d9d062835fd4c705a159e4abb
ToppCellmedial-mesenchymal-Alveolar_Fibroblast-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLEKHH2 ABCA9 SLC29A1 STEAP1

4.89e-052004545c0716bf375c8158f7dc2c82bf5eaf37af594dd0
ToppCellmedial-mesenchymal-Alveolar_Fibroblast|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLEKHH2 ABCA9 SLC29A1 STEAP1

4.89e-05200454c22cbfecee00183dd4be678f116ab9fd9ad0a4dd
ToppCellmedial-2-mesenchymal-Alveolar_Fibroblast|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLEKHH2 ABCA9 SLC29A1 STEAP1

4.89e-05200454cc6062dac07916c29091fc6bee2b864d29e6525b
ToppCellParenchymal-10x5prime-Stromal-Peri/Epineurial_|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TMEM38A NPFFR2 ABCA9 STEAP1

4.89e-052004544c3c11dd5e71ebc3d62264eeaeb71a850b149779
ToppCell(53)_Lymphoid_DC|World / shred on Cell_type and subtype

GPR143 CCDC81 GPR157 NRP2

5.70e-0520845430212cfacad94a7cc562a69efa73a31259851515
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chodl|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NPFFR2 GPR143 SCN4A

3.57e-041374535cb84392e4483f50e09fb7395e2ec98f3eb6ecf3
ToppCell(01)_Cycling_Basal_(homeostasis)-(3)_72hpi|(01)_Cycling_Basal_(homeostasis) / shred by cell type and Timepoint

GNRHR VPS13C

3.64e-0428452ef8053df22b28c772eb39c5e4033f96eb5aa54d9
ToppCellControl-Neu_1|World / 5 Neutrophil clusters in COVID-19 patients

WASHC4 PLEKHH2 TMC7

3.65e-04138453b7920c9a28d28220e7e4b30cd91ba13d0548eb76
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8|TCGA-Bladder / Sample_Type by Project: Shred V9

CCNG2 TMC7 SLC23A2

4.56e-0414945389705865e94360c1288ee98c5a6b381f3c6242b3
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_3|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CHRNA6 AMPD3 CD300LB

4.74e-041514530b6b37734430918378ed94e40877f0c4ae9b25ec
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_8|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCDC81 TNFRSF10D NRP2

4.74e-04151453cba0939a6dd3519f6890695f5b237266ca1a7941
ToppCellCiliated_cells-A-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

CCDC81 DNAH3 SLC23A2

4.74e-041514539d03ce73af15ef40c592d19b36aff46bebc14c40
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_3|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CHRNA6 AMPD3 CD300LB

4.74e-0415145330225a1a7800b0ae19e16ac164f561379eedb99d
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_8|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CCDC81 TNFRSF10D NRP2

4.74e-04151453a937e3e5a63bfeb37d2cabb3177760ec583dbf11
ToppCellPBMC-Control-cDC_8|Control / Compartment, Disease Groups and Clusters

CCDC81 TNFRSF10D NRP2

4.93e-04153453db1a6914f2033fb0748e0523cffe5d6dc4e901be
ToppCell356C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CHRNA6 TNFAIP3 CRTAM

5.02e-04154453692eb053620db86d301b09bf743ab45fccc245be
ToppCell367C-Lymphocytic-NK_cells-NK_cell_D2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

CACNA1C AMPD3 MAP3K6

5.21e-041564530b3630fd4479291599e1674e87eba6f93877ac3a
ToppCell-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

TNFAIP3 ABCA9 STEAP1

5.21e-04156453f0c4d9d58365b0ae8e10ba1aaf3847fb3f98c7ad
ToppCellChildren_(3_yrs)-Mesenchymal-chondrocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C PLEKHH2 ABCA9

5.31e-04157453f147e24f2ece82e1c54750868954d09b3c461804
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-Tregs|GI_small-bowel / Manually curated celltypes from each tissue

TMEM38A ADCY10 CHRNA6

5.31e-04157453c44bd530e396b08f16f284e185dcb830843959ea
ToppCellfacs-Heart-RV-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM38A TMC7 CD300LB

5.41e-04158453ff9878fd768f22bf2ee4805bac2ba01cb3cb804a
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR160 CHRNB2 CD300LB

5.41e-04158453ad1040bce6ad655c2502d9abb02507ecff177f83
ToppCellfacs-Heart-RV-3m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM38A TMC7 CD300LB

5.41e-041584532a222301474c4dfd9a776e197c10f4c1cacceb62
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR160 CHRNB2 CD300LB

5.41e-04158453ac7aef01eda1dca80d6c5b508649fcad55803a67
ToppCellChildren_(3_yrs)-Mesenchymal-chondrocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C PLEKHH2 ABCA9

5.41e-04158453e5636c0b608d68bd426a2b446ac508e4512e86a4
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CHRNB2 CD300LB STEAP1

5.51e-041594536115cb03c2ad08e4c1b65893d522f685ff0bc692
ToppCellAdult-Mesenchymal-chondrocyte|Adult / Lineage, Cell type, age group and donor

CACNA1C PLEKHH2 ABCA9

5.51e-041594533f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CHRNB2 CD300LB STEAP1

5.61e-04160453a90eb621481fd07a821495db07d1032e109fd386
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADCY10 CACNA1C ADAM7

5.82e-04162453bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-TRGV4_gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRPL10 TNFAIP3 CRTAM

5.92e-0416345311cc18f36604d9a5f4e7fb8626a8f0fb141da5e1
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PPP2R3B AMPD3 GPR160

5.92e-041634530ab043b68e8739adcedda01165a3758cd0d22728
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TMC7 SCN4A NRP2

6.03e-041644538f074940afdbda88a4b697a7ddc687e09a4b818b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TMC7 SCN4A NRP2

6.03e-04164453a784f47f67a5eda84d58ad7d9400e3978edbb487
ToppCellAdult-Mesenchymal-myofibroblast_cell-D231|Adult / Lineage, Cell type, age group and donor

CACNA1C PLEKHH2 ABCA9

6.03e-041644533d8ff70fe5582d1fb56b338be8b76fa1428b3657
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TMC7 SCN4A NRP2

6.03e-041644531a1795969673232191425dde84ab24ee6a98143f
ToppCellAdult-Mesenchymal-chondrocyte-D231|Adult / Lineage, Cell type, age group and donor

CACNA1C PLEKHH2 ABCA9

6.03e-041644532ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCell343B-Myeloid-Dendritic-cDC_activated|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CCDC81 MAP3K6 NRP2

6.03e-04164453eae6d440877b292ad18dc4bd02802dda5b2f9c60
ToppCellAdult-Immune-dendritic_cell|Adult / Lineage, Cell type, age group and donor

MYOZ2 GPR157 SCN4A

6.14e-04165453073f52698dac1fe4edd7410865f81b30e1c7196a
ToppCelldroplet-Marrow-BM-1m-Hematologic-proerythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM38A MYOZ2 CD300LB

6.25e-04166453758817f38e843db4ef6ab3e2bfb9f1a2075c9af9
ToppCell356C-Myeloid-Macrophage-SPP1+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

RAB12 CCDC81 TMC7

6.25e-041664538d5d09f25e8903d481c2097fed435e69d42ccdb5
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNF17 ABCA9 SCN4A

6.25e-04166453bb8135119dc37fdbba476599a56d368f422688dc
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TMEM38A MYOZ2 EVC

6.36e-0416745391b14df450bfb6a2b406c88f8c75cd51eeb9e82b
ToppCell356C-Myeloid-Dendritic-cDC_activated|356C / Donor, Lineage, Cell class and subclass (all cells)

CCDC81 GPR157 NRP2

6.36e-0416745343a9375fdbafd7450c553e4620e21537e08639dd
ToppCellCTRL-Myeloid-Monocyte|CTRL / Disease state, Lineage and Cell class

TNFAIP3 TNFRSF10D CD300LB

6.47e-0416845313dca90c7b811e4d5e8fa44f5e892e29be9787a6
ToppCellAdult-Immune-enucleated_erythrocyte-D122|Adult / Lineage, Cell type, age group and donor

TMEM38A PEX12 CD300LB

6.58e-04169453d5624e5b3687bd3f18f3a2b47a94d11eb1fbdb75
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EVC PLEKHH2 ABCA9

6.58e-041694538f397cf4f9fd7c6fa88d01a95289ce2a6bc6938d
ToppCell343B-Myeloid-Dendritic-cDC_activated|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

CCDC81 GPR157 NRP2

6.58e-04169453e68e6c24606fd46eca6f86bb63fa86ea17879ae2
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l5|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CCDC81 TNFAIP3 CRTAM

6.58e-041694531de3ae36d3b60e961bfd9f7bdc37867b82a0417f
ToppCell(7)_MNP-(7)_DC_activated|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)

ADCY10 CCDC81 GPR157

6.69e-041704534ab495b38a071fa8207331df2ce0d78a2dcd034e
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NPFFR2 CACNA1C PLEKHH2

6.69e-041704535570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell356C-Myeloid-Dendritic-cDC_activated|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

CCDC81 GPR157 NRP2

6.69e-04170453513d9036aa41d4d902da8baa66a66206abb6f3b0
ToppCellCTRL-Myeloid-Monocyte|Myeloid / Disease state, Lineage and Cell class

AMPD3 TNFAIP3 CD300LB

6.81e-04171453bfa01571516a0b24476ae06cb07f56c5579dbd70
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic-migDC|lymph-node_spleen / Manually curated celltypes from each tissue

CCDC81 GPR157 NRP2

6.92e-041724531b24bed3cd8e3fa463c5e7cefdf9e99e639e2f84
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_10|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CCDC81 GPR157 NRP2

7.04e-0417345309a13407a41ff2cba82fc417b72bf9a24ce6c42e
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_10|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CCDC81 GPR157 NRP2

7.04e-04173453bfec038a6783f166240da4861e100643c6ea80a5
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5-6_RORB_LINC00320|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPFFR2 PLEKHH2 NRP2

7.04e-041734534ec147479b359cce1975d57a50ee1437a0e1e663
ToppCell367C-Myeloid-Dendritic-cDC_activated|367C / Donor, Lineage, Cell class and subclass (all cells)

CCNG2 GPR157 NRP2

7.04e-0417345394f99f7e7813d6e53e0bedf97087400b1bf00129
ToppCellControl-Myeloid-MoAM2,_CCL18|Control / Condition, Lineage and Cell class

AMPD3 ABCA9 NRP2

7.16e-041744534c64ff5666812fb4efa440ba4faeca51d916d68e
ToppCell(2)_NK/T-(23)_CD4+_T_cell-(232)_CD4+/CD45RA+_Naive_T_cell|(23)_CD4+_T_cell / immune cells in Peripheral Blood (logTPM normalization)

EDAR GPR160 CRTAM

7.28e-04175453fc40fda0fb9954cb0970c6ac71f6d6df7d27dc5c
ToppCellmetastatic_Brain-T/NK_cells-Exhausted_Tfh|metastatic_Brain / Location, Cell class and cell subclass

TNFAIP3 STIMATE CRTAM

7.28e-04175453b732c6a423c28856211002107d8c611dcfb6f265
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TMEM38A RNF17 GPR157

7.40e-04176453d30241fb8119834d6e7b59efec3f92fc7a3d1247
ToppCell356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|356C / Donor, Lineage, Cell class and subclass (all cells)

PLEKHH2 ABCA9 STEAP1

7.52e-04177453cdfd2f0ee2f692271b1525e414b0f645cdadb1f6
ToppCellControl-Myeloid-MoAM2,_CCL18|Myeloid / Condition, Lineage and Cell class

AMPD3 ABCA9 NRP2

7.52e-04177453470f54fe2b21c7350ea471e02039461a3808f700
ToppCell356C-Fibroblasts-Fibroblast-C_(Myofibroblast)|356C / Donor, Lineage, Cell class and subclass (all cells)

PLEKHH2 ABCA9 STEAP1

7.52e-04177453db222faaecbe5600da39277243c4e7e764eb63c9
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Activated_DCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

CCDC81 GPR157 NRP2

7.52e-04177453370aee11a6dc2c6f4366a13c3171f37bc5b32d65
ToppCell367C-Myeloid-Dendritic-cDC_activated|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CCNG2 CCDC81 GPR157

7.52e-04177453a0ff337f11bdb11959ac71805ff94be6b4ec1083
ToppCelldroplet-Fat-Scat-21m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYOZ2 EDAR STEAP1

7.65e-041784535fc9f41609735b972a2cd0830182d13742cd5bf5
ToppCellBAL-Control-Myeloid-MoAM-MoAM2|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AMPD3 TNFAIP3 CD300LB

7.77e-041794532fca4117c58824562ec80c7713fe15689a28efb3
ToppCellBAL-Control-Myeloid-MoAM-MoAM2-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AMPD3 TNFAIP3 CD300LB

7.77e-04179453898425fa81526a2e00fca7a25085229ff1f31069
ToppCell-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

CACNA1C PLEKHH2 ABCA9

7.77e-0417945310fadbaa1b6d21cbf9f354d717cc4c225619f4fd
ToppCellBAL-Control-Myeloid-MoAM-MoAM2-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

AMPD3 TNFAIP3 CD300LB

7.90e-04180453dcec59d66995f701d816eaeea3ed1439a2f71b73
ToppCellBAL-Control-Myeloid-MoAM-MoAM2|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

AMPD3 TNFAIP3 CD300LB

7.90e-04180453f3d8329b7e754c1ed89b0f39b8cd9e2ae22f6725
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1C PLEKHH2 GPR157

7.90e-0418045308ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell10x5'v1-week_12-13-Lymphocytic_T-T_NK-CD8_T_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

EDAR GIMAP2 CRTAM

7.90e-041804535273aa2b939b5c640d708d6ca1812550dff5ec0f
ToppCellControl-Myeloid-MoAM2|Control / Disease group,lineage and cell class （2021.01.30）

AMPD3 TNFAIP3 CD300LB

7.90e-0418045338892483a6a5388765aec87f0119c0b9bb5c7cbd
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1C PLEKHH2 GPR157

7.90e-041804539b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1C PLEKHH2 GPR157

8.02e-041814539e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-Lymphoid_DC|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCDC81 GPR157 NRP2

8.28e-041834539ca4954faaba50466c35121d6765895e955178aa
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AMPD3 SLC29A1 NRP2

8.28e-04183453262387ee8d43b96e5f1a77c75124459a506a6172
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AMPD3 SLC29A1 NRP2

8.28e-04183453c85a707acbcb582912e8ac080a36d05f91cfd7a2
ToppCellmild_COVID-19-NK_CD56bright|World / disease group, cell group and cell class (v2)

CACNA1C TNFAIP3 CRTAM

8.28e-041834539a4899afac0f91203209392c5f67b3d0aa356b86
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NPFFR2 CACNA1C PLEKHH2

8.42e-04184453102b6f621a5b551e622f97b12d787c080b052a72
ToppCell(7)_DC_activated|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

ADCY10 CCDC81 GPR157

8.42e-04184453b89871a3e36fde6daa68daf116f8c8d587554c0f
ToppCellnucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-maDC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CCNG2 GPR157 NRP2

8.55e-041854537e3d9f5050e71e91021245c11101e994ae41d22b
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-Lymphoid_DC|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCDC81 GPR157 NRP2

8.55e-0418545348de4d9fad55077732bf64eca4919103ecbc1512
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CACNA1C PLEKHH2 NRP2

8.55e-041854531ac6a32cc56d5d819649bdd99518e2ead0eead4c
DrugRH 1

CACNA1C TNFAIP3 TNFRSF10D SCN4A

5.11e-0659444CID000394347
Drugdisopyramide

CHRNA6 TNFAIP3 CHRNB2 SCN4A

8.01e-0666444CID000003114
Drugalpha-conotoxin MII

CHRNA6 CHRNB2

2.18e-054442ctd:C098872
DrugPerphenazine [58-39-9]; Up 200; 10uM; MCF7; HT_HG-U133A

CCNG2 CHRNA6 TNFAIP3 RNF17 CHRNB2

2.97e-051874455698_UP
DrugClemastine fumarate [14976-57-9]; Up 200; 8.6uM; MCF7; HT_HG-U133A

CCNG2 TMC7 MAP3K6 VPS13C GPR107

3.37e-051924457485_UP
DrugCaptopril [62571-86-2]; Up 200; 17.2uM; HL60; HG-U133A

CCNG2 RNF17 SLC23A2 VPS13C GPR107

3.45e-051934451988_UP
DrugMetanephrine hydrochloride DL [881-95-8]; Up 200; 17.2uM; MCF7; HT_HG-U133A

GPR143 AMPD3 TNFAIP3 SLC29A1 VPS13C

3.71e-051964451515_UP
DrugBrompheniramine maleate [980-71-2]; Up 200; 9.2uM; MCF7; HT_HG-U133A

CCNG2 GPR143 AMPD3 CHRNB2 SCN4A

3.81e-051974454131_UP
DrugPindolol [13523-86-9]; Up 200; 16.2uM; PC3; HT_HG-U133A

AMPD3 EDAR VPS13C CHRNB2 SCN4A

3.90e-051984454496_UP
DrugAlthiazide [5588-16-9]; Up 200; 10.4uM; PC3; HT_HG-U133A

MYOZ2 EDAR VPS13C CHRNB2 NRP2

3.90e-051984454491_UP
DrugSolasodine [126-17-0]; Down 200; 9.6uM; PC3; HT_HG-U133A

DNAH3 AMPD3 SLC23A2 GPR107 NRP2

3.90e-051984453749_DN
DrugBenzydamine hydrochloride [132-69-4]; Up 200; 11.6uM; PC3; HT_HG-U133A

CCNG2 CHRNA6 TNFAIP3 GNRHR NRP2

3.99e-051994455811_UP
DrugQX-222

CHRNA6 CHRNB2 SCN4A

7.33e-0542443CID000005014
Diseasecongenital myasthenic syndrome (implicated_via_orthology)

CHRNA6 CHRNB2

2.34e-0416422DOID:3635 (implicated_via_orthology)
DiseaseC-X-C motif chemokine 10 measurement

CCNG2 NPFFR2 GNRHR

5.07e-04109423EFO_0008056
Diseasepsychosis predisposition measurement

CACNA1C TMC7

6.29e-0426422EFO_0008337
Diseasehair morphology

EDAR SLC23A2

7.84e-0429422EFO_0005038
Diseaseresponse to vaccine, cytokine measurement

OMA1 DNAH3 STIMATE

8.65e-04131423EFO_0004645, EFO_0004873

Protein segments in the cluster

PeptideGeneStartEntry
IFLMILLIPQVKEKF

ADAM7

6

Q9H2U9
TLAFLMSVLIKKPFL

ABCA9

316

Q8IUA7
VNILDRFLALMKVKP

CCNG2

81

Q16589
QLEILFMKILKLIVK

ADCY10

621

Q96PN6
KMLENIFLPLFKATI

AMPD3

491

Q01432
IFLKLVDDILKKMPL

RAB12

196

Q6IQ22
KQKIIKMLLIVALLF

NPFFR2

371

Q9Y5X5
VLQPVLKMKVDELFL

PPP2R3B

6

Q9Y5P8
DKKIFMIVIPLQVLA

GPR107

366

Q5VW38
HPKLEKTFFVLILLM

OR13C6P

21

Q8NH95
HPKLEKTFFVLILLM

OR13C7

21

P0DN81
AIVLIIMFYILKTKP

EDAR

201

Q9UNE0
LVLVLEMNKVLLPAK

MAP3K6

526

O95382
AKPKMEIILQFLIFD

NRP2

181

O60462
FAMAKPKILEITLLI

PLEKHH2

1426

Q8IVE3
IIVLLKVQIPAYIEM

GPR160

261

Q9UJ42
VKTVFLKLLPQVLLM

CHRNA6

341

Q15825
LFTVEMILKLIAFKP

CACNA1C

1281

Q13936
SLLFIIPKKLMIFLR

GIMAP2

311

Q9UG22
IIPLFIMLICNAKII

GNRHR

221

P30968
LFIIVQLFIMKLRKA

CRTAM

301

O95727
KFFIPQLIMIKLEVS

DNAH3

481

Q8TD57
FILIQRPVFIMVEKL

CCDC81

71

Q6ZN84
VIKIRFFKIMLVLII

GPR143

241

P51810
SMADKKLVLIPLIFI

GPR157

221

Q5UAW9
FIQIFKMCLLDLLPK

EVC

236

P57679
KFKNIIHLIVMDPFV

SCN4A

566

P35499
SIMFLVLLPYLKVKL

PEX12

116

O00623
LMILKPVQKLFAIIV

OMA1

151

Q96E52
ALPFFVITMIKIVLI

SLC29A1

136

Q99808
FMIAVFLPIVVLIFK

STEAP1

291

Q9UHE8
KVVFLEKLPALLFMQ

CHRNB2

336

P17787
YMLLVFVKVPILLIL

CD300LB

151

A8K4G0
KILKFVVFIVAVLLP

TNFRSF10D

36

Q9UBN6
IFVVPKLSEFELIKM

RNF17

1196

Q9BXT8
KLLKEYLMVIEIPVQ

TNFAIP3

301

P21580
ILMKVFPNQVLKPFL

MRPL10

121

Q7Z7H8
YKLQLFKMFPIILAI

SLC23A2

306

Q9UGH3
MAIKFLEVIKPFCVI

SEC61A1

1

P61619
MVKEFIIKISPIILN

VPS13C

2196

Q709C8
DLKLAIVMLIVPFFV

STIMATE

191

Q86TL2
LTPLMEKFKILLEKL

XPOT

621

O43592
ELFPLQVVMKKLDLI

WASHC4

576

Q2M389
FLPVKLIFVAMKEVV

TMEM38A

111

Q9H6F2
IFMLVLLPVLLTKYK

TMC7

181

Q7Z402
MVKFKVPDFELLLLT

MYOZ2

201

Q9NPC6