Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chromatin binding	ZNF609 RARA USP51 ASXL3 NAP1L1 TAF5 EZH1 L3MBTL3 HNRNPU	4.78e-05	739	47	9	GO:0003682
GeneOntologyMolecularFunction	histone binding	USP51 RSF1 NAP1L1 EZH1 L3MBTL3	3.86e-04	265	47	5	GO:0042393
GeneOntologyMolecularFunction	mRNA methyltransferase activity	RNMT CMTR1	4.16e-04	13	47	2	GO:0008174
Domain	ZF_PHD_2	PHF20 ASXL3 RSF1 RAI1	1.03e-04	95	48	4	PS50016
Domain	ZF_PHD_1	PHF20 ASXL3 RSF1 RAI1	1.07e-04	96	48	4	PS01359
Domain	ZF_CCHHC	ST18 L3MBTL3	1.35e-04	7	48	2	PS51802
Domain	TCEAL1	TCEAL7 TCEAL2	2.30e-04	9	48	2	IPR010370
Domain	TF_A-like/BEX	TCEAL7 TCEAL2	5.77e-04	14	48	2	IPR021156
Domain	BEX	TCEAL7 TCEAL2	5.77e-04	14	48	2	PF04538
Domain	-	SLTM HNRNPU	1.32e-03	21	48	2	1.10.720.30
Domain	SAP	SLTM HNRNPU	1.45e-03	22	48	2	PF02037
Domain	PHD	PHF20 RSF1 RAI1	1.55e-03	89	48	3	SM00249
Domain	SAP	SLTM HNRNPU	1.58e-03	23	48	2	SM00513
Domain	Znf_PHD	PHF20 RSF1 RAI1	1.65e-03	91	48	3	IPR001965
Domain	SAP	SLTM HNRNPU	1.87e-03	25	48	2	PS50800
Domain	SAP_dom	SLTM HNRNPU	1.87e-03	25	48	2	IPR003034
Domain	AT_hook	PHF20 ZNF653	2.18e-03	27	48	2	SM00384
Domain	AT_hook_DNA-bd_motif	PHF20 ZNF653	2.18e-03	27	48	2	IPR017956
Domain	HMGI/Y_DNA-bd_CS	PHF20 ZNF653	2.87e-03	31	48	2	IPR000637
Domain	TF_fork_head_CS_2	FOXI3 FOXJ1	6.23e-03	46	48	2	IPR030456
Domain	TF_fork_head_CS_1	FOXI3 FOXJ1	6.49e-03	47	48	2	IPR018122
Domain	WW	MAGI2 CMTR1	6.49e-03	47	48	2	PF00397
Domain	WW	MAGI2 CMTR1	6.77e-03	48	48	2	SM00456
Domain	FH	FOXI3 FOXJ1	7.04e-03	49	48	2	SM00339
Domain	FORK_HEAD_1	FOXI3 FOXJ1	7.04e-03	49	48	2	PS00657
Domain	FORK_HEAD_2	FOXI3 FOXJ1	7.04e-03	49	48	2	PS00658
Domain	Fork_head_dom	FOXI3 FOXJ1	7.04e-03	49	48	2	IPR001766
Domain	FORK_HEAD_3	FOXI3 FOXJ1	7.04e-03	49	48	2	PS50039
Domain	Forkhead	FOXI3 FOXJ1	7.04e-03	49	48	2	PF00250
Domain	WW_DOMAIN_2	MAGI2 CMTR1	7.61e-03	51	48	2	PS50020
Domain	WW_DOMAIN_1	MAGI2 CMTR1	7.61e-03	51	48	2	PS01159
Domain	WW_dom	MAGI2 CMTR1	7.90e-03	52	48	2	IPR001202
Domain	EGF_extracell	ADAM8 ITGB1	1.04e-02	60	48	2	IPR013111
Domain	EGF_2	ADAM8 ITGB1	1.04e-02	60	48	2	PF07974
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	ZNF609 CMTR1 AHNAK NAP1L1 SLTM ITGB1 L3MBTL3 HNRNPU	1.89e-07	444	49	8	34795231
Pubmed	Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.	AHNAK RSF1 NAP1L1 SLTM ZC3H18 HNRNPU	2.65e-07	188	49	6	29721183
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ZNF609 RARA AHNAK RSF1 SLTM ZC3H18 THOC2 L3MBTL3 RAI1 HNRNPU	7.17e-07	954	49	10	36373674
Pubmed	Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins.	IGF1R ITGB1	1.94e-06	2	49	2	15289498
Pubmed	Integrin expression regulates neuroblastoma attachment and migration.	IGF1R ITGB1	1.94e-06	2	49	2	15256055
Pubmed	Protective effect of hyaluronic acid on interleukin-1-induced deregulation of beta1-integrin and insulin-like growth factor-I receptor signaling and collagen biosynthesis in cultured human chondrocytes.	IGF1R ITGB1	1.94e-06	2	49	2	17899316
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	ZNF609 RARA PPP4R2 NAP1L1 PSME1 THOC2 L3MBTL3 VARS1 RAI1 HNRNPU	2.64e-06	1103	49	10	34189442
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	AHNAK RSF1 NAP1L1 SLTM ZC3H18 EZH1 L3MBTL3	4.08e-06	469	49	7	27634302
Pubmed	A census of human transcription factors: function, expression and evolution.	RARA PHF20 NEUROD4 DBP EZH1 FOXI3 ST18 ZNF653 FOXJ1	4.36e-06	908	49	9	19274049
Pubmed	Activation of β1 integrins and caveolin-1 by TF/FVIIa promotes IGF-1R signaling and cell survival.	IGF1R ITGB1	5.83e-06	3	49	2	32458278
Pubmed	Extracellular Prolidase (PEPD) Induces Anabolic Processes through EGFR, β1-integrin, and IGF-1R Signaling Pathways in an Experimental Model of Wounded Fibroblasts.	IGF1R ITGB1	5.83e-06	3	49	2	33477899
Pubmed	USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer.	USP51 ITGB1	5.83e-06	3	49	2	37386737
Pubmed	Evidence for genetic regulation of mRNA expression of the dosage-sensitive gene retinoic acid induced-1 (RAI1) in human brain.	RARA RAI1	5.83e-06	3	49	2	26743651
Pubmed	Phosphoenolpyruvate-dependent inhibition of collagen biosynthesis, alpha2beta1 integrin and IGF-I receptor signaling in cultured fibroblasts.	IGF1R ITGB1	5.83e-06	3	49	2	18491034
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	RNMT PPP4R2 AHNAK RSF1 NAP1L1 SLTM ZC3H18 PSME1 THOC2	1.06e-05	1014	49	9	32416067
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ZNF609 PHF20 AHNAK SLTM ZC3H18 TAF5 THOC2 L3MBTL3 RAI1 HNRNPU	1.07e-05	1294	49	10	30804502
Pubmed	The developmental basis for scaling of mammalian tooth size.	IGF1R FOXI3	1.16e-05	4	49	2	37307487
Pubmed	Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase.	IGF1R ITGB1	1.16e-05	4	49	2	33477820
Pubmed	The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells.	CYSLTR1 ITGB1	1.16e-05	4	49	2	19454674
Pubmed	A tagging-via-substrate technology for detection and proteomics of farnesylated proteins.	RRAS2 NAP1L1	1.16e-05	4	49	2	15308774
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	AHNAK NAP1L1 ZC3H18 TAF5 VARS1 RAI1	1.89e-05	394	49	6	27248496
Pubmed	Insulin and Insulin-Like Growth Factor 1 Signaling Preserves Sarcomere Integrity in the Adult Heart.	IGF1R ITGB1	1.94e-05	5	49	2	36125265
Pubmed	Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha2beta1 integrin activity.	IGF1R ITGB1	1.94e-05	5	49	2	18413316
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	ZNF609 SLTM ZC3H18 THOC2 HNRNPU	2.42e-05	244	49	5	29884807
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	RARA NEUROD4 DBP TAF5 EZH1 L3MBTL3 RAI1 FOXJ1	2.86e-05	877	49	8	20211142
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	CMTR1 AHNAK RSF1 SLTM THOC2 L3MBTL3 RAI1	3.19e-05	645	49	7	25281560
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	AHNAK RSF1 NAP1L1 SLTM ZC3H18 THOC2 RAI1	3.45e-05	653	49	7	22586326
Pubmed	Cysteinyl-leukotriene type 1 receptors transduce a critical signal for the up-regulation of eosinophilopoiesis by interleukin-13 and eotaxin in murine bone marrow.	CYSLTR1 CCL13	4.07e-05	7	49	2	20219953
Pubmed	RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix.	IGF1R ITGB1	4.07e-05	7	49	2	11884618
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	AHNAK RSF1 NAP1L1 PSME1 THOC2 ADAM8 L3MBTL3 HNRNPU	4.17e-05	925	49	8	28986522
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	NAP1L1 SLTM ZC3H18 HNRNPU	5.75e-05	148	49	4	32538781
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	RRAS2 AHNAK NAP1L1 SLTM THOC2 ITGB1 VARS1 HNRNPU	8.49e-05	1024	49	8	24711643
Pubmed	Topoisomerase IIbeta negatively modulates retinoic acid receptor alpha function: a novel mechanism of retinoic acid resistance.	RARA HNRNPU	8.69e-05	10	49	2	18212063
Pubmed	The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells.	PHF20 L3MBTL3	1.06e-04	11	49	2	33097091
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	AHNAK RSF1 SLTM THOC2 HNRNPU	1.16e-04	340	49	5	29478914
Pubmed	Nomenclature guidelines for X-linked mental retardation.	THOC2 WNK3	1.50e-04	13	49	2	1605216
Pubmed	An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.	RRAS2 AHNAK NAP1L1 VARS1 HNRNPU	2.38e-04	397	49	5	21319273
Pubmed	The DNA sequence of the human X chromosome.	TCEAL7 USP51 CYSLTR1 TCEAL2 WNK3	2.67e-04	407	49	5	15772651
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	DOCK11 SLTM TRDN	3.02e-04	92	49	3	15840729
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	AHNAK TRDN WNK3 HNRNPU	3.39e-04	235	49	4	30258100
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	IGF1R RNMT ITGB1	3.97e-04	101	49	3	23382219
Pubmed	CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis.	IGF1R RSF1	4.01e-04	21	49	2	22154806
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	RSF1 ZC3H18 RAI1	4.21e-04	103	49	3	32744500
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	AHNAK RSF1 NAP1L1 ZC3H18	4.35e-04	251	49	4	31076518
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	RNMT AHNAK NAP1L1 SLTM THOC2 VARS1 HNRNPU	4.46e-04	989	49	7	36424410
Pubmed	The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.	AHNAK NAP1L1 HNRNPU	5.10e-04	110	49	3	18307411
Pubmed	Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events.	TCEAL7 TCEAL2	5.26e-04	24	49	2	16221301
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	AHNAK PSME1 VARS1 HNRNPU	5.41e-04	266	49	4	19380743
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	DOCK11 AHNAK TCEAL2 FBXO43 RAI1 HNRNPU	5.67e-04	736	49	6	29676528
Pubmed	Mass spectrometry-based proteomics revealed Glypican-1 as a novel ADAM17 substrate.	NAP1L1 ITGB1 HNRNPU	5.96e-04	116	49	3	27576135
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	RNMT AHNAK SLTM ZC3H18 PSME1 ITGB1 VARS1 HNRNPU	5.99e-04	1367	49	8	32687490
Pubmed	Identification of novel markers of mouse fetal ovary development.	MAGI2 ADAM8	6.18e-04	26	49	2	22844512
Pubmed	Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation.	IGF1R FOXJ1	6.18e-04	26	49	2	27861515
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	ZNF609 PPP4R2 AHNAK SLTM PSME1 ITGB1 L3MBTL3	6.33e-04	1049	49	7	27880917
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	RNMT AHNAK NAP1L1 VARS1 HNRNPU	6.46e-04	494	49	5	26831064
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	TCEAL7 RNMT SLTM ZC3H18 THOC2 VARS1 HNRNPU	7.60e-04	1082	49	7	38697112
Pubmed	Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development.	ASXL3 FBXO43	8.25e-04	30	49	2	38310234
Pubmed	Germline deletion of Cdyl causes teratozoospermia and progressive infertility in male mice.	RARA FBXO43	8.25e-04	30	49	2	30850578
Pubmed	Lats1/2 inactivation reveals Hippo function in alveolar type I cell differentiation during lung transition to air breathing.	ITGB1 FOXJ1	8.81e-04	31	49	2	30305289
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	MAGI2 RRAS2 CMTR1 ASXL3 AHNAK ITGB1 VARS1 HNRNPU	8.84e-04	1451	49	8	30550785
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	AHNAK SLTM EZH1 ITGB1 VARS1 HNRNPU	8.93e-04	803	49	6	36517590
Pubmed	TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT-GSK-3β-β-Catenin Signaling Pathway.	RARA AHNAK ITGB1 HNRNPU	9.01e-04	305	49	4	33194618
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	CMTR1 RSF1 ZC3H18 TAF5 THOC2	9.08e-04	533	49	5	30554943
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	AHNAK NAP1L1 TAF5 THOC2 VARS1 HNRNPU	9.28e-04	809	49	6	32129710
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	AHNAK NAP1L1 SLTM PSME1 HNRNPU	9.46e-04	538	49	5	28524877
Pubmed	Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.	MAGI2 KLHL36	9.98e-04	33	49	2	20966902
Pubmed	The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways.	CCL13 FOXJ1	9.98e-04	33	49	2	23213461
Pubmed	SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.	ZNF609 AHNAK NAP1L1 VARS1 HNRNPU	1.11e-03	558	49	5	27591049
Pubmed	A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells.	RSF1 NAP1L1	1.12e-03	35	49	2	29104064
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	RNMT AHNAK RSF1 NAP1L1 PSME1 HNRNPU	1.15e-03	844	49	6	25963833
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	AHNAK NAP1L1 VARS1 HNRNPU	1.23e-03	332	49	4	32786267
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	RRAS2 CMTR1 ITGB1 L3MBTL3 VARS1 FOXJ1	1.25e-03	857	49	6	25609649
Pubmed	Characterization of HMGB1/2 Interactome in Prostate Cancer by Yeast Two Hybrid Approach: Potential Pathobiological Implications.	RSF1 HNRNPU	1.32e-03	38	49	2	31694235
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	AHNAK THOC2 ITGB1 HNRNPU	1.34e-03	340	49	4	24332808
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ZNF609 IGF1R AHNAK RSF1 THOC2 ITGB1 HNRNPU	1.41e-03	1203	49	7	29180619
GeneFamily	Transcription elongation factor A like family	TCEAL7 TCEAL2	1.53e-04	9	38	2	1216
Coexpression	GSE3982_MAST_CELL_VS_CENT_MEMORY_CD4_TCELL_DN	RRAS2 CMTR1 C1S TAF5 EZH1 ADAM8	1.84e-06	198	49	6	M5448
Coexpression	GSE16385_MONOCYTE_VS_12H_IFNG_TNF_TREATED_MACROPHAGE_UP	RRAS2 RARA ZDHHC23 KLHL36 ITGB1 L3MBTL3	1.95e-06	200	49	6	M7917
Coexpression	SIMBULAN_UV_RESPONSE_IMMORTALIZED_DN	IGF1R AHNAK NAP1L1	2.66e-05	31	49	3	M3732
Coexpression	GSE24671_CTRL_VS_SENDAI_VIRUS_INFECTED_MOUSE_SPLENOCYTES_DN	PPP4R2 AHNAK SLTM ZC3H18 RAI1	3.49e-05	199	49	5	M9443
Coexpression	GSE16522_MEMORY_VS_NAIVE_CD8_TCELL_DN	IGF1R ZDHHC23 NAP1L1 SLTM PSME1	3.57e-05	200	49	5	M3659
Coexpression	GSE36891_UNSTIM_VS_POLYIC_TLR3_STIM_PERITONEAL_MACROPHAGE_DN	CMTR1 CYSLTR1 CCL13 PSME1 L3MBTL3	3.57e-05	200	49	5	M8781
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_1000_k-means-cluster#1	PHF20 USP51 PPP4R2 RSF1 SLTM WNK3	2.80e-05	259	49	6	Facebase_RNAseq_e8.5_Floor Plate_1000_K1
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-Double_negative_Thymocyte,_DN4_(Cd8-,_Cd4-),_some_undergoing_VDJ_recombination_\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUSTN1 IGF1R AHNAK ADAM8 RHOU	1.52e-06	178	49	5	408e41c853f608965cef9111fb87fdc311cdc7a8
ToppCell	(1)_T_cell-(11)_Activated_CD4_T\|(1)_T_cell / shred on Cell_type and subtype	CYSLTR1 AHNAK TCEAL2 NAP1L1 HNRNPU	2.56e-06	198	49	5	4b9ad91342f622c63e476d4f6a0ae5bf282a7ef5
ToppCell	IIH-CD4-CD8_2\|IIH / Condition, Cell_class and T cell subcluster	USP51 TRAIP TCEAL2 ZNF653	1.57e-05	137	49	4	5614a086f5f698e0965f3c7699cffefec5c3b87e
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZDHHC23 CYSLTR1 PSME1 ADAM8	2.81e-05	159	49	4	a5fee9e7ee00c20a4ba30b0dfaf1189fb109a1af
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC1\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZDHHC23 CYSLTR1 PSME1 ADAM8	3.17e-05	164	49	4	662f74ad2656c0af158dbf9eb81d5bf70f54e529
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CMTR1 CCDC30 ADAM8 VARS1	3.57e-05	169	49	4	c6e5b179461996ced6c7621dc01cec00d401f4e8
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	CMTR1 CCDC30 ADAM8 VARS1	3.73e-05	171	49	4	26b34dc069cc15b75a0c13cb8c5d81e074788160
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-B_cell-B_cell\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CYSLTR1 AHNAK NAP1L1 HNRNPU	4.46e-05	179	49	4	fad1fbee002fcd424c03460d695559060ce41a3f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-B_cell\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CYSLTR1 AHNAK NAP1L1 HNRNPU	4.46e-05	179	49	4	6d4e4b64e633b2ae8514ffa1e45829d6508dac54
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-B_cell-B_cell-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CYSLTR1 AHNAK NAP1L1 HNRNPU	4.46e-05	179	49	4	61a7cc01fae4115325fce0efaa5bacf8f9af5ba2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SNX30 RRAS2 IGF1R DOCK11	5.29e-05	187	49	4	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	Control-B_memory-3\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	CYSLTR1 AHNAK DBP ITGB1	6.22e-05	195	49	4	135234f068da3e8db7213b53c09ed6d1d0cdc351
ToppCell	CV-Moderate-6\|Moderate / Virus stimulation, Condition and Cluster	RRAS2 PHF20 ADAM8 ITGB1	6.22e-05	195	49	4	2b8a72d7e755b9655c7a496000d10ff06e50862b
ToppCell	CV-Moderate-6\|CV / Virus stimulation, Condition and Cluster	RRAS2 PHF20 ADAM8 ITGB1	6.35e-05	196	49	4	7bced0cc2112697593c478fa291b8ed3941fb811
ToppCell	B_cell_maturation-Memory_B_cell\|B_cell_maturation / Lineage and Cell class	CYSLTR1 AHNAK NAP1L1 ITGB1	6.35e-05	196	49	4	869ed6c83dfe0d874ea2bf2e358f54e5011e80e6
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	AHNAK RSF1 SLTM THOC2	6.47e-05	197	49	4	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	Control-Control-Lymphocyte-T/NK-NK_activated\|Control / Disease, condition lineage and cell class	MAGI2 CMTR1 AHNAK TRAIP	6.60e-05	198	49	4	76d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TCEAL7 NAP1L1 C1S ITGB1	6.60e-05	198	49	4	ebceb11f50b8a6ebb7629fdbd3d31fb131ace6fd
ToppCell	T_cells-CCR7+_T_cells\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	IGF1R CYSLTR1 NAP1L1 HNRNPU	6.73e-05	199	49	4	467820d6abe3024d9d655b9672c2f9cdc1303db3
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_2\|Classical_Monocyte / Disease condition and Cell class	AHNAK NAP1L1 PSME1 HNRNPU	6.73e-05	199	49	4	3feee9f53860b4b2e93ff2360beb2b2b74f51d24
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-OPC_related-Oligodendrocyte/OPC\|10w / Sample Type, Dataset, Time_group, and Cell type.	NEUROD4 NAP1L1 ITGB1 ST18	6.86e-05	200	49	4	345f1eac498cc87fd7bf08e7312608b2d6fe1dd7
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-OPC_related\|10w / Sample Type, Dataset, Time_group, and Cell type.	NEUROD4 NAP1L1 ITGB1 ST18	6.86e-05	200	49	4	8f5d98f962ddd8c4658c89ff8a2894de1228562a
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MUSTN1 NEUROD4 CCL13 ST18	6.86e-05	200	49	4	501a3b93624df463458a35d3e6648d4ccc941724
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2-L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	MUSTN1 NEUROD4 CCL13 ST18	6.86e-05	200	49	4	d1f36a8232411933b1494168ec912fd0e5246428
ToppCell	severe-CD4+_T_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	IGF1R RNMT KLHL36 NAP1L1	6.86e-05	200	49	4	f74bdabadca8ad6dae1b6e6812c66325aac50db0
Disease	Neurobehavioral Manifestations	MAGI2 RAI1	1.76e-04	12	49	2	C0525041
Disease	amyotrophic lateral sclerosis (biomarker_via_orthology)	IGF1R RARA	2.08e-04	13	49	2	DOID:332 (biomarker_via_orthology)
Disease	Epileptic encephalopathy	MAGI2 HNRNPU	1.14e-03	30	49	2	C0543888
Disease	osteoporosis (is_implicated_in)	IGF1R DBP	1.22e-03	31	49	2	DOID:11476 (is_implicated_in)
Disease	Squamous cell carcinoma of lung	IGF1R WNK3	1.30e-03	32	49	2	C0149782
Disease	Growth Disorders	IGF1R RAI1	1.64e-03	36	49	2	C0018273
Disease	Anxiety States, Neurotic	MAGI2 RAI1	2.44e-03	44	49	2	C0376280
Disease	Anxiety Disorders	MAGI2 RAI1	2.44e-03	44	49	2	C0003469
Disease	Anxiety neurosis (finding)	MAGI2 RAI1	2.44e-03	44	49	2	C1279420

Protein segments in the cluster

Peptide	Gene	Start	Entry
RTKLGKEICADPKEK	CCL13	66	Q99616
VELECPDAKLKGPKF	AHNAK	1896	Q09666
ECKVKPAGELCRPKK	ADAM8	456	P78325
VKCEPGKLLVEPDVK	ASXL3	1841	Q9C0F0
KPKLKEKVRPEGTCE	RAI1	1716	Q7Z5J4
DRNKKKKEVPKPECS	RARA	161	P10276
DLEALKKKGCPPDDI	ITGB1	66	P05556
KKDEEKEDPKGIPEF	NAP1L1	156	P55209
DNEEEDPKCSRKKKP	L3MBTL3	161	Q96JM7
IKKKRPPVKDEDLKG	MUSTN1	11	Q8IVN3
DCFKKVPRDEDDPGK	FOXI3	201	A8MTJ6
CVCALEPRPEDKKKK	KLHL36	591	Q8N4N3
LDPRLAKKAKPPEEC	MAGI2	331	Q86UL8
AKKAKPPEECKENEL	MAGI2	336	Q86UL8
TPVKEVKPGEKRDEK	CCDC178	141	Q5BJE1
VKPGEKRDEKCPELK	CCDC178	146	Q5BJE1
GPCPKVCEEEKKTKT	IGF1R	326	P08069
RGPKGPEEKKDCEVV	HNRNPU	486	Q00839
KKCILPRKEKDKTPE	FBXO43	126	Q4G163
GIEPDIKPFEEKCNK	DOCK11	351	Q5JSL3
PLRKCKEVKVEKPTA	C1S	591	P09871
LCPKLGERKQKEIPE	CCDC30	141	Q5VVM6
NKCFIKVPREKDEPG	FOXJ1	176	Q92949
KRKLDPEIVPEEKDC	RNMT	81	O43148
PKEPASCLLKEKERK	DBP	41	Q10586
PIKVEVKECRADPKD	RSF1	321	Q96T23
KDEKKKGEDEDKGPP	PSME1	86	Q06323
DPECTAPIKKQKKRV	CMTR1	6	Q8N1G2
KDFEKRGKKEVCPVL	PPP4R2	11	Q9NY27
PKQPDKEGKLICSEK	PHF20	191	Q9BVI0
GEKKPKPEKREKRDP	VARS1	261	P26640
EEGENEEGKPKKKKP	TAF5	391	Q15542
GKKEDCVKGDPVEKE	SLTM	306	Q9NWH9
SPEPTRKEKDKKGCH	RRAS2	186	P62070
KEEKEDPELKCPVIG	ST18	806	O60284
PRKKASLPEKGEEIC	CYSLTR1	321	Q9Y271
KENEGKPKCSVPKRE	TCEAL7	6	Q9BRU2
DKCKEKPVPEEAAKL	RHOU	176	Q7L0Q8
CETKEQEPKLVKPKK	USP51	336	Q70EK9
CLLKKEEKEEPVAPE	ZNF653	396	Q96CK0
GKDGKEKPKEERPNK	THOC2	1296	Q8NI27
RKEDRPKVPADVEKC	SNX30	361	Q5VWJ9
RKNKEIKIEPEPCGT	EZH1	321	Q92800
EGKVKNDICEEKKPE	ZNF609	936	O15014
GKRVEEPLKDKEKPE	TCEAL2	51	Q9H3H9
KKKKTEEPELEPLCC	ZDHHC23	11	Q8IYP9
KDKEPIKGKEEKVPA	TRDN	471	Q13061
DREKEREKEKGKPKP	ZC3H18	471	Q86VM9
DVPKKICKGPRKESQ	TRAIP	351	Q9BWF2
IKKTREKKPAGCLEE	WNK3	491	Q9BYP7
EEDGEKPKRRGPKKK	NEUROD4	61	Q9HD90