Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	translation elongation factor activity	EEFSEC EEF1A1 EEF1A1P5 EEF1A2	5.07e-07	20	66	4	GO:0003746
GeneOntologyMolecularFunction	pyrophosphatase activity	EEFSEC ERCC6 MYO9B APTX CHD3 BTAF1 ABCC2 KIF17 EEF1A1 EEF1A1P5 EEF1A2 DNAH11	1.70e-05	839	66	12	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	EEFSEC ERCC6 MYO9B APTX CHD3 BTAF1 ABCC2 KIF17 EEF1A1 EEF1A1P5 EEF1A2 DNAH11	1.72e-05	840	66	12	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	EEFSEC ERCC6 MYO9B APTX CHD3 BTAF1 ABCC2 KIF17 EEF1A1 EEF1A1P5 EEF1A2 DNAH11	1.72e-05	840	66	12	GO:0016818
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	EEFSEC ERCC6 MYO9B CHD3 BTAF1 ABCC2 KIF17 EEF1A1 EEF1A1P5 EEF1A2 DNAH11	4.29e-05	775	66	11	GO:0017111
GeneOntologyMolecularFunction	translation factor activity, RNA binding	EEFSEC EEF1A1 EEF1A1P5 EEF1A2	1.80e-04	85	66	4	GO:0008135
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERCC6 APTX CHD3 BTAF1 THAP9 TOP2A	2.27e-04	262	66	6	GO:0140097
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	ERCC6 CHD3 BTAF1	2.47e-04	37	66	3	GO:0140658
GeneOntologyMolecularFunction	phosphatidylinositol phosphate 4-phosphatase activity	SYNJ1 PIP4P1	4.76e-04	10	66	2	GO:0034596
GeneOntologyMolecularFunction	translation regulator activity, nucleic acid binding	EEFSEC EEF1A1 EEF1A1P5 EEF1A2	5.17e-04	112	66	4	GO:0090079
GeneOntologyMolecularFunction	ATP hydrolysis activity	ERCC6 MYO9B CHD3 BTAF1 ABCC2 KIF17 DNAH11	6.19e-04	441	66	7	GO:0016887
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate phosphatase activity	SYNJ1 PIP4P1	6.95e-04	12	66	2	GO:0106019
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	ERCC6 CHD3 BTAF1 TOP2A	8.29e-04	127	66	4	GO:0008094
GeneOntologyMolecularFunction	ATP-dependent activity	ERCC6 MYO9B CHD3 BTAF1 ABCC2 KIF17 TOP2A DNAH11	9.12e-04	614	66	8	GO:0140657
GeneOntologyBiologicalProcess	translational elongation	EEFSEC GRM5 EEF1A1 EEF1A1P5 EEF1A2	1.37e-05	97	65	5	GO:0006414
GeneOntologyCellularComponent	eukaryotic translation elongation factor 1 complex	EEF1A1 EEF1A2	5.87e-05	4	66	2	GO:0005853
Domain	G_TR_1	EEFSEC EEF1A1 EEF1A2	1.18e-05	13	66	3	PS00301
Domain	Transl_elong_EF1A_euk/arc	EEF1A1 EEF1A2	1.23e-05	2	66	2	IPR004539
Domain	EFTu-like_2	EEFSEC EEF1A1 EEF1A2	3.31e-05	18	66	3	IPR004161
Domain	GTP_EFTU_D2	EEFSEC EEF1A1 EEF1A2	3.31e-05	18	66	3	PF03144
Domain	G_TR_2	EEFSEC EEF1A1 EEF1A2	3.31e-05	18	66	3	PS51722
Domain	TF_GTP-bd_dom	EEFSEC EEF1A1 EEF1A2	3.92e-05	19	66	3	IPR000795
Domain	Transl_B-barrel	EEFSEC EEF1A1 EEF1A2	1.16e-04	27	66	3	IPR009000
Domain	RA	MYO9B GRB14 RASSF9	1.77e-04	31	66	3	SM00314
Domain	SNF2_N	ERCC6 CHD3 BTAF1	1.94e-04	32	66	3	IPR000330
Domain	SNF2_N	ERCC6 CHD3 BTAF1	1.94e-04	32	66	3	PF00176
Domain	RA	MYO9B GRB14 RASSF9	3.01e-04	37	66	3	PS50200
Domain	Transl_elong_EFTu/EF1A_C	EEF1A1 EEF1A2	3.40e-04	8	66	2	IPR004160
Domain	GTP_EFTU_D3	EEF1A1 EEF1A2	3.40e-04	8	66	2	PF03143
Domain	ZINC_FINGER_C2H2_2	CTCFL ZNF140 ZBTB39 APTX ZNF624 ZNF701 ZNF615 BCL11A ZNF236 PRDM15	3.67e-04	775	66	10	PS50157
Domain	ZINC_FINGER_C2H2_1	CTCFL ZNF140 ZBTB39 APTX ZNF624 ZNF701 ZNF615 BCL11A ZNF236 PRDM15	3.74e-04	777	66	10	PS00028
Domain	RA_dom	MYO9B GRB14 RASSF9	3.79e-04	40	66	3	IPR000159
Domain	G_TR_CS	EEF1A1 EEF1A2	4.36e-04	9	66	2	IPR031157
Domain	Znf_C2H2-like	CTCFL ZNF140 ZBTB39 APTX ZNF624 ZNF701 ZNF615 BCL11A ZNF236 PRDM15	4.53e-04	796	66	10	IPR015880
Domain	Znf_C2H2	CTCFL ZNF140 ZBTB39 APTX ZNF624 ZNF701 ZNF615 BCL11A ZNF236 PRDM15	4.95e-04	805	66	10	IPR007087
Domain	ZnF_C2H2	CTCFL ZNF140 ZBTB39 APTX ZNF624 ZNF701 ZNF615 BCL11A ZNF236 PRDM15	5.09e-04	808	66	10	SM00355
Domain	Transl_elong_EF1A/Init_IF2_C	EEF1A1 EEF1A2	5.43e-04	10	66	2	IPR009001
Domain	-	CTCFL ZNF140 ZBTB39 ZNF624 ZNF701 ZNF615 BCL11A ZNF236 PRDM15	6.11e-04	679	66	9	3.30.160.60
Domain	zf-C2H2	CTCFL ZNF140 ZBTB39 ZNF624 ZNF701 ZNF615 BCL11A ZNF236 PRDM15	7.07e-04	693	66	9	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	CTCFL ZNF140 ZBTB39 ZNF624 ZNF701 ZNF615 BCL11A ZNF236 PRDM15	7.14e-04	694	66	9	IPR013087
Domain	P-loop_NTPase	EEFSEC ERCC6 MYO9B CHD3 BTAF1 ABCC2 KIF17 EEF1A1 EEF1A2 DNAH11	7.41e-04	848	66	10	IPR027417
Domain	Ubiquitin-rel_dom	MYO9B PIK3CB GRB14 RASSF9	4.08e-03	184	66	4	IPR029071
Domain	-	EEFSEC ERCC6 CHD3 BTAF1 ABCC2 EEF1A1 EEF1A2 DNAH11	4.63e-03	746	66	8	3.40.50.300
Domain	zf-C2H2_6	ZNF140 ZNF624 ZNF701 ZNF615 ZNF236	5.03e-03	314	66	5	PF13912
Domain	Helicase_C	ERCC6 CHD3 BTAF1	6.44e-03	107	66	3	PF00271
Domain	HELICc	ERCC6 CHD3 BTAF1	6.44e-03	107	66	3	SM00490
Domain	Helicase_C	ERCC6 CHD3 BTAF1	6.61e-03	108	66	3	IPR001650
Domain	HELICASE_CTER	ERCC6 CHD3 BTAF1	6.78e-03	109	66	3	PS51194
Domain	HELICASE_ATP_BIND_1	ERCC6 CHD3 BTAF1	6.78e-03	109	66	3	PS51192
Domain	DEXDc	ERCC6 CHD3 BTAF1	6.78e-03	109	66	3	SM00487
Domain	Helicase_ATP-bd	ERCC6 CHD3 BTAF1	6.95e-03	110	66	3	IPR014001
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	KMT2A CPD CHD3 HEATR1 EEF1A1 EEF1A2	2.65e-06	202	67	6	24639526
Pubmed	Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3.	EEF1A1 EEF1A1P5 EEF1A2	3.06e-06	15	67	3	8812466
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	ABCC2 FREM3 EEF1A1 EEF1A1P5 EEF1A2	3.10e-06	116	67	5	30652415
Pubmed	Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations.	KMT2A TOP2A	3.66e-06	2	67	2	31202576
Pubmed	New insights on the interaction between the isoforms 1 and 2 of human translation elongation factor 1A.	EEF1A1 EEF1A2	3.66e-06	2	67	2	26212729
Pubmed	The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade.	EEF1A1 EEF1A2	3.66e-06	2	67	2	17825975
Pubmed	Dissecting the expression of EEF1A1/2 genes in human prostate cancer cells: the potential of EEF1A2 as a hallmark for prostate transformation and progression.	EEF1A1 EEF1A2	3.66e-06	2	67	2	22095224
Pubmed	eEF1A demonstrates paralog specific effects on HIV-1 reverse transcription efficiency.	EEF1A1 EEF1A2	3.66e-06	2	67	2	30782564
Pubmed	Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons.	FLNA HCN1	3.66e-06	2	67	2	24403084
Pubmed	Genome-wide association study in German patients with attention deficit/hyperactivity disorder.	BCL11A GRM5	3.66e-06	2	67	2	22012869
Pubmed	Understanding functions of eEF1 translation elongation factors beyond translation. A proteomic approach.	EEF1A1 EEF1A2	3.66e-06	2	67	2	38220433
Pubmed	Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation.	EEF1A1 EEF1A2	3.66e-06	2	67	2	19636410
Pubmed	Analysis of the Expression and Subcellular Distribution of eEF1A1 and eEF1A2 mRNAs during Neurodevelopment.	EEF1A1 EEF1A2	3.66e-06	2	67	2	35741005
Pubmed	The role of translation elongation factor eEF1 subunits in neurodevelopmental disorders.	EEF1A1 EEF1A2	3.66e-06	2	67	2	30370994
Pubmed	Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway.	EEF1A1 EEF1A2	3.66e-06	2	67	2	7945283
Pubmed	Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia.	EEF1A1 EEF1A2	3.66e-06	2	67	2	32347192
Pubmed	HDM2-binding partners: interaction with translation elongation factor EF1alpha.	KRT14 MDM2 EEF1A1	8.87e-06	21	67	3	17373842
Pubmed	Mdm2 selectively suppresses DNA damage arising from inhibition of topoisomerase II independent of p53.	MDM2 TOP2A	1.10e-05	3	67	2	28692049
Pubmed	The expression pattern of Bcl11a, Mdm2 and Pten genes in B-cell acute lymphoblastic leukemia.	BCL11A MDM2	1.10e-05	3	67	2	28544358
Pubmed	Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro.	EEF1A1 EEF1A2	1.10e-05	3	67	2	19559761
Pubmed	Interaction of the pacemaker channel HCN1 with filamin A.	FLNA HCN1	1.10e-05	3	67	2	15292205
Pubmed	A novel 3'tRNA-derived fragment tRF-Val promotes proliferation and inhibits apoptosis by targeting EEF1A1 in gastric cancer.	MDM2 EEF1A1	1.10e-05	3	67	2	35585048
Pubmed	The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alpha.	EEF1A1 EEF1A2	1.10e-05	3	67	2	18448518
Pubmed	Endogenous epitope tagging of eEF1A2 in mice reveals early embryonic expression of eEF1A2 and subcellular compartmentalisation of neuronal eEF1A1 and eEF1A2.	EEF1A1 EEF1A2	1.10e-05	3	67	2	37429391
Pubmed	Inhibition of FOXQ1 induces apoptosis and suppresses proliferation in prostate cancer cells by controlling BCL11A/MDM2 expression.	BCL11A MDM2	1.10e-05	3	67	2	27573292
Pubmed	Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F.	FLNA KRT14 EEF1A1 EEF1A1P5	1.38e-05	75	67	4	31527668
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	FLNA KRT14 PDE6A KMT2A PABPC1L CHD3 HEATR1 ABCC2 TOP2A SLC6A14 EEF1A1 EEF1A2	1.79e-05	1442	67	12	35575683
Pubmed	Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted mice.	EEF1A1 EEF1A2	2.19e-05	4	67	2	11294870
Pubmed	Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours.	KRT14 KMT2A	2.19e-05	4	67	2	23736260
Pubmed	Identification of regulators of chaperone-mediated autophagy.	EEF1A1 EEF1A2	2.19e-05	4	67	2	20797626
Pubmed	The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer.	KRT14 KMT2A	2.19e-05	4	67	2	30625324
Pubmed	The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.	LAMTOR5 MDM2	2.19e-05	4	67	2	26229107
Pubmed	Immuno-characterization of the switch of peptide elongation factors eEF1A-1/EF-1alpha and eEF1A-2/S1 in the central nervous system during mouse development.	EEF1A1 EEF1A2	2.19e-05	4	67	2	15013623
Pubmed	beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53.	FLNA MDM2	3.64e-05	5	67	2	17984062
Pubmed	The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein.	EEF1A1 EEF1A2	3.64e-05	5	67	2	18649364
Pubmed	Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions.	CYP17A1 AS3MT	3.64e-05	5	67	2	18682255
Pubmed	Targeting cell membrane HDM2: A novel therapeutic approach for acute myeloid leukemia.	KMT2A MDM2	3.64e-05	5	67	2	31337857
Pubmed	Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA.	EEF1A1 EEF1A2	3.64e-05	5	67	2	8626763
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	FLNA KRT14 MYO9B BTAF1 EEF1A1	4.53e-05	202	67	5	33005030
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	KMT2A CHD3 BCL11A TOP2A	4.82e-05	103	67	4	32744500
Pubmed	The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.	FLNA GRM5	5.46e-05	6	67	2	11943148
Pubmed	Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress.	EEF1A1 EEF1A2	5.46e-05	6	67	2	16888816
Pubmed	Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.	CYP17A1 KMT2A ABCC2 TOP2A	5.80e-05	108	67	4	19956635
Pubmed	The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.	CTCFL ZNF624 SEMA4G EEF1A1 DNAH11	6.79e-05	220	67	5	24705354
Pubmed	Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.	CHD3 BCL11A	7.63e-05	7	67	2	26816381
Pubmed	Cockayne's Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation.	ERCC6 MDM2	7.63e-05	7	67	2	29225035
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	FLNA KRT14 PTGR2 CHD3 TOP2A EEF1A1P5 EEF1A2	7.95e-05	538	67	7	28524877
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	FLNA KRT14 SYNJ1 SYN2 KMT2A CHD3 BCL11A GRM5 EEF1A1 EEF1A2 DNAH11	8.50e-05	1431	67	11	37142655
Pubmed	A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.	ITGA11 ERCC6 CYP17A1 MDM2	9.02e-05	121	67	4	19789190
Pubmed	Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95.	MDM2 EEF1A1	1.02e-04	8	67	2	23260144
Pubmed	YB-1 is important for an early stage embryonic development: neural tube formation and cell proliferation.	EEF1A1 EEF1A2	1.02e-04	8	67	2	17082189
Pubmed	KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity.	HEATR1 MDM2 TOP2A	1.26e-04	50	67	3	32068487
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	FLNA SYN2 EEF1A1 EEF1A2	1.26e-04	132	67	4	16944949
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	EEFSEC ZBTB39 OXCT1 HEATR1 TOP2A	1.54e-04	262	67	5	36880596
Pubmed	Apoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-dependent and results in male sterility.	CYP17A1 MDM2	1.63e-04	10	67	2	26470726
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	FLNA CHD3 TOP2A EEF1A1 EEF1A2	1.80e-04	271	67	5	32433965
Pubmed	Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination.	PKD1L1 DNAH11	1.99e-04	11	67	2	27272319
Pubmed	Genome-wide association study of tanning phenotype in a population of European ancestry.	GRM5 PRDM15	1.99e-04	11	67	2	19340012
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	FLNA PDZD7 EEF1A1 EEF1A1P5 EEF1A2	1.99e-04	277	67	5	30745168
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	FLNA MYO9B CHD3 HEATR1 TOP2A EEF1A1 EEF1A1P5 EEF1A2	2.14e-04	844	67	8	25963833
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	KRT14 ZNF701 ZNF615 ZNF236 EEF1A1 EEF1A1P5	2.35e-04	451	67	6	36168627
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	MYO9B TLE3 CHSY3 BTAF1 HEATR1 MDM2 PRDM15 TOP2A	2.38e-04	857	67	8	25609649
Pubmed	IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A.	FLNA EEF1A1	2.38e-04	12	67	2	30013108
Pubmed	LncRNA SAMD12-AS1 promotes cell proliferation and inhibits apoptosis by interacting with NPM1.	FLNA MDM2	2.38e-04	12	67	2	31406141
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	EEFSEC FLNA ZBTB39 TLE3 KMT2A CHD3 BCL11A TOP2A EEF1A1	2.58e-04	1103	67	9	34189442
Pubmed	Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway.	EEF1A1 EEF1A2	2.81e-04	13	67	2	29285303
Pubmed	CCG repeats in cDNAs from human brain.	HCN1 CHD3	3.28e-04	14	67	2	9921901
Pubmed	CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination.	ERCC6 MDM2	3.28e-04	14	67	2	22032989
Pubmed	A global genomic transcriptional code associated with CNS-expressed genes.	TLE3 APTX GRB14 BCL11A SEMA4G	3.76e-04	318	67	5	16919269
Pubmed	Excitatory glutamate is essential for development and maintenance of the piloneural mechanoreceptor.	KRT14 GRM5	3.78e-04	15	67	2	22241839
Pubmed	TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77.	TOP2A EEF1A1	3.78e-04	15	67	2	19321449
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF140 ZNF624 ZNF701 ZNF615	4.21e-04	181	67	4	37372979
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	FLNA SYNJ1 KMT2A CHD3 BTAF1 HEATR1 TOP2A EEF1A2	4.22e-04	934	67	8	33916271
Pubmed	Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.	CYP17A1 GRB14	4.31e-04	16	67	2	21572416
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	FLNA MYO9B LOXL2 CHD3 TOP2A	4.58e-04	332	67	5	37433992
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	FLNA KMT2A CHD3 HEATR1 TOP2A EEF1A1 EEF1A1P5 EEF1A2	4.86e-04	954	67	8	36373674
Pubmed	Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.	FLNA KRT14 EEF1A1 EEF1A2	5.16e-04	191	67	4	33762435
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	LOXL2 TLE3 CPD CHD3 BTAF1 ZNF236 WDR13 PRDM15 FGGY EEF1A2	5.38e-04	1489	67	10	28611215
Pubmed	SARS-CoV-2 ORF8 Protein Induces Endoplasmic Reticulum Stress-like Responses and Facilitates Virus Replication by Triggering Calnexin: an Unbiased Study.	FLNA EEF1A1	5.48e-04	18	67	2	36877072
Pubmed	Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.	EEF1A1 EEF1A2	5.48e-04	18	67	2	12426392
Pubmed	The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2.	TOP2A EEF1A1	5.48e-04	18	67	2	19961560
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	KMT2A BTAF1 TOP2A EEF1A1	5.57e-04	195	67	4	19454010
Pubmed	Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.	KRT14 LOXL2 PABPC1L EEF1A1	5.79e-04	197	67	4	23686814
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	ERCC6 CYP17A1 ZNF624 ABCC2 MDM2	5.89e-04	351	67	5	20453000
Pubmed	The sperm-associated antigen 6 interactome and its role in spermatogenesis.	INTS10 AGA DDHD1 BTAF1	6.01e-04	199	67	4	31146259
Pubmed	Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.	CTCFL MDM2	6.12e-04	19	67	2	14578343
Pubmed	Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.	CYP17A1 DDHD1 AS3MT EEF1A2	6.24e-04	201	67	4	23535732
Pubmed	Profiling of Parkin-binding partners using tandem affinity purification.	PABPC1L EEF1A1 EEF1A1P5 EEF1A2	6.48e-04	203	67	4	24244333
Pubmed	LUCAT1 promotes colorectal cancer tumorigenesis by targeting the ribosomal protein L40-MDM2-p53 pathway through binding with UBA52.	MDM2 EEF1A1	6.79e-04	20	67	2	30690837
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	FLNA ERCC6 KMT2A TOP2A	7.35e-04	210	67	4	16565220
Pubmed	ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.	KMT2A CHD3	7.50e-04	21	67	2	12453419
Pubmed	Sox2 modulates the function of two distinct cell lineages in mouse skin.	KRT14 SYN2	7.50e-04	21	67	2	23948231
Pubmed	Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.	FLNA KRT14 EEF1A1	7.59e-04	92	67	3	37343697
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	FLNA ITGA11 KRT14 OXCT1 SYN2 EEF1A1	7.65e-04	564	67	6	21565611
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLNA KRT14 MYO9B CHD3 BTAF1 HEATR1 TOP2A EEF1A1	7.71e-04	1024	67	8	24711643
Pubmed	Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2.	EEF1A1 EEF1A1P5 EEF1A2	8.08e-04	94	67	3	36584595
Pubmed	Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities.	TOP2A EEF1A1P5	8.24e-04	22	67	2	31839203
Pubmed	The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex.	HCN1 GRM5 SEMA4G	9.12e-04	98	67	3	19554387
Pubmed	Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation.	KRT14 TOP2A	9.82e-04	24	67	2	25043184
Pubmed	Highly efficient purification of protein complexes from mammalian cells using a novel streptavidin-binding peptide and hexahistidine tandem tag system: application to Bruton's tyrosine kinase.	FLNA EEF1A2	9.82e-04	24	67	2	21080425
Interaction	FER1L6 interactions	EEF1A1 EEF1A1P5 EEF1A2	1.16e-06	7	66	3	int:FER1L6
Interaction	H2BC12 interactions	LOXL2 KMT2A CHD3 MDM2 TOP2A EEF1A1 EEF1A1P5 EEF1A2	1.00e-05	322	66	8	int:H2BC12
Interaction	ADARB2 interactions	EEF1A1 EEF1A1P5 EEF1A2	2.21e-05	17	66	3	int:ADARB2
Cytoband	Ensembl 112 genes in cytogenetic band chr10q24	CYP17A1 AS3MT PDZD7 ABCC2 SEMA4G	8.81e-06	189	67	5	chr10q24
Cytoband	10q24.31	PDZD7 SEMA4G	3.53e-04	19	67	2	10q24.31
Cytoband	8p21.3	INTS10 LOXL2	1.43e-03	38	67	2	8p21.3
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	CTCFL ZNF140 ZBTB39 ZNF624 ZNF701 ZNF615 BCL11A ZNF236 PRDM15	8.21e-05	718	47	9	28
GeneFamily	Phosphoinositide phosphatases	SYNJ1 PIP4P1	3.12e-03	32	47	2	1079
ToppCell	15-Airway-Epithelial-Submucosal_gland_basal\|Airway / Age, Tissue, Lineage and Cell class	KRT14 LOXL2 ETV7 BCL11A SLC6A14	5.80e-06	170	67	5	61f8dd5e27df1b8d01ccfd0d25247b34aa8d182c
ToppCell	Mid-temporal_gyrus_(MTG)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DCDC1 SYN2 CHSY3 CHD3 FREM3	7.25e-06	178	67	5	ad187db4c40b9078d54dd915c143e0172b2f47b8
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT14 OXCT1 SCNN1G GRB14 DNAH11	7.66e-06	180	67	5	fc5b9d0e3215652e490ca72d69f776e9725608b2
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT14 OXCT1 SCNN1G GRB14 DNAH11	7.66e-06	180	67	5	6763b22f2383931c747b37cd0ae2f60b08f64d90
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYN2 GRB14 ZNF615 SEMA4G DNAH11	1.16e-05	196	67	5	7e98380d815fbf6254289ace2af37aac6fef51e8
Drug	AC1L1KGC	ITGA11 PDE6A PIK3CB AGA CPD MDM2 GRM5	4.41e-06	225	67	7	CID000005486
Disease	developmental and epileptic encephalopathy 33 (implicated_via_orthology)	EEF1A1 EEF1A1P5 EEF1A2	1.02e-08	3	65	3	DOID:0080463 (implicated_via_orthology)
Disease	Breast Carcinoma	FLNA KRT14 PIK3CB LAMTOR5 LOXL2 TLE3 CYP17A1 MDM2 TOP2A	2.69e-06	538	65	9	C0678222
Disease	Apraxia of Phonation	CHD3 BCL11A	1.43e-05	3	65	2	C0264611
Disease	Mammary Carcinoma, Human	FLNA KRT14 LAMTOR5 LOXL2 TLE3 CYP17A1 MDM2 TOP2A	1.97e-05	525	65	8	C4704874
Disease	Mammary Neoplasms, Human	FLNA KRT14 LAMTOR5 LOXL2 TLE3 CYP17A1 MDM2 TOP2A	1.97e-05	525	65	8	C1257931
Disease	Mammary Neoplasms	FLNA KRT14 LAMTOR5 LOXL2 TLE3 CYP17A1 MDM2 TOP2A	2.03e-05	527	65	8	C1458155
Disease	Malignant neoplasm of breast	FLNA KRT14 ERCC6 PIK3CB LAMTOR5 LOXL2 TLE3 CYP17A1 BCL11A MDM2 TOP2A	2.09e-05	1074	65	11	C0006142
Disease	X-24328 measurement	HCN1 SYN2	9.96e-05	7	65	2	EFO_0800873
Disease	response to hydrochlorothiazide, diastolic blood pressure change measurement	OXCT1 PKD1L1	2.13e-04	10	65	2	EFO_0005202, EFO_0006945
Disease	prostate carcinoma, type 2 diabetes mellitus	EEFSEC SYN2 ZNF236	3.04e-04	59	65	3	EFO_0001663, MONDO_0005148
Disease	acute myeloid leukemia (implicated_via_orthology)	KMT2A TOP2A	3.11e-04	12	65	2	DOID:9119 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	SYN2 EEF1A1 EEF1A1P5 EEF1A2	4.67e-04	163	65	4	DOID:1826 (implicated_via_orthology)
Disease	Neuralgia, Supraorbital	CYP17A1 GRM5	5.62e-04	16	65	2	C0038870
Disease	Neuralgia, Iliohypogastric Nerve	CYP17A1 GRM5	5.62e-04	16	65	2	C0423712
Disease	Neuralgia, Perineal	CYP17A1 GRM5	5.62e-04	16	65	2	C0423711
Disease	amygdala volume change measurement	PKD1L1 FGGY	5.62e-04	16	65	2	EFO_0021490
Disease	Neuralgia	CYP17A1 GRM5	5.62e-04	16	65	2	C0027796
Disease	pancreatic ductal carcinoma (is_implicated_in)	HEATR1 MDM2	5.62e-04	16	65	2	DOID:3587 (is_implicated_in)
Disease	Neuralgia, Atypical	CYP17A1 GRM5	5.62e-04	16	65	2	C0234247
Disease	Neuralgia, Stump	CYP17A1 GRM5	5.62e-04	16	65	2	C0234249
Disease	Paroxysmal Nerve Pain	CYP17A1 GRM5	5.62e-04	16	65	2	C0751373
Disease	Nerve Pain	CYP17A1 GRM5	5.62e-04	16	65	2	C0751372
Disease	Neuralgia, Ilioinguinal	CYP17A1 GRM5	5.62e-04	16	65	2	C0751371
Disease	Neuralgia, Vidian	CYP17A1 GRM5	5.62e-04	16	65	2	C0042656
Disease	obsolete_red blood cell distribution width	EEFSEC INTS10 MYO9B AS3MT SYN2 CHSY3 BCL11A FREM3 EEF1A1 EEF1A1P5	6.90e-04	1347	65	10	EFO_0005192
Disease	Schizophrenia	MYO9B PIK3CB AGA SYN2 KMT2A BCL11A GRM5 KIF17	6.96e-04	883	65	8	C0036341
Disease	dilated cardiomyopathy (implicated_via_orthology)	EEF1A1 EEF1A1P5 EEF1A2	7.43e-04	80	65	3	DOID:12930 (implicated_via_orthology)
Disease	prostate specific antigen measurement	EEFSEC CHD3 BCL11A DNAH11	7.98e-04	188	65	4	EFO_0004624
Disease	Epilepsy, Cryptogenic	FLNA HCN1 EEF1A2	7.98e-04	82	65	3	C0086237
Disease	Awakening Epilepsy	FLNA HCN1 EEF1A2	7.98e-04	82	65	3	C0751111
Disease	Aura	FLNA HCN1 EEF1A2	7.98e-04	82	65	3	C0236018
Disease	chronic myeloid leukemia (is_implicated_in)	ABCC2 MDM2	9.77e-04	21	65	2	DOID:8552 (is_implicated_in)
Disease	Attention Deficit Disorder	AS3MT GRM5	1.07e-03	22	65	2	C0041671
Disease	Bronchiectasis	SCNN1G DNAH11	1.07e-03	22	65	2	C0006267
Disease	Minimal Brain Dysfunction	AS3MT GRM5	1.07e-03	22	65	2	C1321905
Disease	Squamous cell carcinoma of esophagus	KRT14 LOXL2 ABCC2	1.22e-03	95	65	3	C0279626
Disease	Attention deficit hyperactivity disorder	AS3MT GRM5	1.28e-03	24	65	2	C1263846
Disease	glioblastoma (is_implicated_in)	PIK3CB MDM2	1.28e-03	24	65	2	DOID:3068 (is_implicated_in)
Disease	response to antiviral drug, cirrhosis of liver	FAXC EEF1A2	1.28e-03	24	65	2	EFO_0001422, EFO_0010123
Disease	Visual seizure	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C0270824
Disease	Epileptic drop attack	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C0270846
Disease	attention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia	AS3MT KMT2A ZNF615	1.46e-03	101	65	3	EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
Disease	Generalized seizures	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C0234533
Disease	Clonic Seizures	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C0234535
Disease	Vertiginous seizure	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C0422855
Disease	Gustatory seizure	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C0422854
Disease	Seizures, Somatosensory	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C0422850
Disease	Olfactory seizure	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C0422853
Disease	Seizures, Auditory	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C0422852
Disease	Generalized Absence Seizures	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C4505436
Disease	Convulsive Seizures	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C0751494
Disease	Seizures, Sensory	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C0751496
Disease	Jacksonian Seizure	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C0022333
Disease	Non-epileptic convulsion	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C0751056
Disease	Atonic Absence Seizures	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C0751123
Disease	Complex partial seizures	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C0149958
Disease	Single Seizure	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C0751110
Disease	Epileptic Seizures	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C4317109
Disease	Nonepileptic Seizures	HCN1 SYN2 ABCC2	1.46e-03	101	65	3	C3495874
Disease	Tonic Seizures	HCN1 SYN2 ABCC2	1.50e-03	102	65	3	C0270844
Disease	Weight Gain	GRB14 FGGY DNAH11	1.50e-03	102	65	3	C0043094
Disease	Absence Seizures	HCN1 SYN2 ABCC2	1.50e-03	102	65	3	C4316903
Disease	Convulsions	HCN1 SYN2 ABCC2	1.50e-03	102	65	3	C4048158
Disease	Seizures, Focal	HCN1 SYN2 ABCC2	1.59e-03	104	65	3	C0751495
Disease	Myoclonic Seizures	HCN1 SYN2 ABCC2	1.59e-03	104	65	3	C4317123
Disease	Tonic - clonic seizures	HCN1 SYN2 ABCC2	1.59e-03	104	65	3	C0494475
Disease	blood manganese measurement	TLE3 FREM3	1.62e-03	27	65	2	EFO_0007581
Disease	Epilepsy	FLNA HCN1 EEF1A2	1.81e-03	109	65	3	C0014544

Protein segments in the cluster

Peptide	Gene	Start	Entry
GTMKIHILQKHGENV	CTCFL	411	Q8NI51
ELLKHMHTVGEKVIV	APTX	236	Q7Z2E3
KIISGIHNEVHALGM	DNAH11	2946	Q96DT5
FKKSVGVHSVMKHDA	ERCC6	1256	Q03468
MKAGLKIHSHLSGIQ	RASSF9	326	O75901
MLIKHHTVTRGITKG	INTS10	656	Q9NVR2
HITKGIVKREMHGHG	FAXC	236	Q5TGI0
HSGMAATHQKAVKII	DCDC1	1401	M0R2J8
TLKTHHVQDSKMGFV	GRM5	386	P41594
KVMDVHDGKVVSTHE	KRT14	451	P02533
HGDVNSNKVVMSGVK	LOXL2	496	Q9Y4K0
TRHMKTHGQVGKDVY	BCL11A	786	Q9H165
ITILKMHSAKGHQKA	OR5B2	221	Q96R09
SVLHVMVKKGQVTGV	PDPR	211	Q8NCN5
HSQAVEVLKGQTHIM	PDZD7	271	Q9H5P4
LDMGIVGHVAHSKKI	PDE6A	136	P16499
GEMENVHGHITIKGT	ABCC2	686	Q92887
GAKKVMIVITDGESH	ITGA11	261	Q9UKX5
IHDVHTQLAGKITGM	PABPC1L	556	Q4VXU2
QHGVAGVITKSSKEM	HCN1	516	O60741
KTPGKMVQDKHSHLE	ETV7	306	Q9Y603
GVVLKHMNETGVHKT	BTAF1	376	O14981
QSVTGKLIDHMVQGH	FGGY	331	Q96C11
EMGTHTVSVKYKGQH	FLNA	2206	P21333
MTVHRIINHSVDKKG	CHD3	631	Q12873
MGKEKTHINIVVIGH	EEF1A2	1	Q05639
MGKEKTHINIVVIGH	EEF1A1	1	P68104
ETLHNLVHKGVKVVM	CNPY3	131	Q9BT09
VRMGTKTTVIVGHHQ	CYP17A1	66	P05093
SMLVEVHKGVHGFVK	CPD	1206	O75976
LVGEKGHVTGIDMTK	AS3MT	91	Q9HBK9
IQKHDGITVAVHKMA	LAMTOR5	76	O43504
TIGMVVIHKTGHIAA	AGA	206	P20933
MGKEKTHINIVVIGH	EEF1A1P5	1	Q5VTE0
VLSMSHGQKIKHFQI	GRB14	476	Q14449
HVTKSSVGHKNEPKM	KMT2A	2766	Q03164
HIGVMKKEELTSHQS	HEATR1	1851	Q9H583
THIVFVVHGIGQKMD	DDHD1	406	Q8NEL9
KVGGSIIHKASNVMH	SCNN1G	181	P51170
FISHVMVKELHTGQG	PKD1L1	1876	Q8TDX9
INVEGKMHQHVVKCG	PIP4P1	91	Q86T03
EKGVYVKGLSMHTVH	KIF17	166	Q9P2E2
ENKATEITMGVIHGK	FREM3	961	P0C091
VVVKIGHAHSGMGKV	SYN2	266	Q92777
HQMVKGGKAEKLHSV	SYNJ1	336	O43426
NTMETHKLIHTVGKQ	PRDM15	1181	P57071
KNGCIVHGKTGHLMA	MDM2	446	Q00987
AKHNVHVMNISTGKK	WDR13	281	Q9H1Z4
HGLQMLKSLQGTHVV	POMK	121	Q9H5K3
KVVVTMEHSAKGNAH	OXCT1	436	P55809
GSVGHMKVLSKQVEA	PIK3CB	701	P42338
KEMGGHNEKKVHILV	CHSY3	611	Q70JA7
KKSQLNIHQKTHMGG	ZNF615	271	Q8N8J6
MVHVTEHQKIHSGEK	ZNF624	736	Q9P2J8
TKAKFHITVGHETVM	EEFSEC	331	P57772
HKAVVLGSGMHIIEE	SEMA4G	456	Q9NTN9
TAHSVQMAKALGIHI	THAP9	376	Q9H5L6
MKVTTKINHHDKING	NPIPB2	141	A6NJ64
VGMESSNVEVLHHTK	TLE3	676	Q04726
STLNLMSKHVGVHKG	ZBTB39	671	O15060
KGGVAVKAHQVKNHM	TOP2A	346	P11388
ISNLVKHQMIHTGKK	ZNF140	201	P52738
QKGALQTHMIKHTGE	ZNF236	236	Q9UL36
SSLVMHKVIHTGEKR	ZNF701	461	Q9NV72
HMAHISGKEVSQVVK	SLC6A14	371	Q9UN76
EKGHITAGSNKTMVV	PTGR2	146	Q8N8N7
VSGHVVLEATTMKKG	MYO9B	1441	Q13459