Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	SREBF2 CXXC5 MAP3K10 HIC2 RBM15 EGR1 AR ZNF503 NEDD4 OVOL2	1.21e-05	1399	29	10	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	SREBF2 CXXC5 MAP3K10 HIC2 RBM15 EGR1 AR ZNF503 NEDD4 OVOL2	1.32e-05	1413	29	10	GO:1902679
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	SREBF2 CXXC5 HIC2 RBM15 EGR1 AR NEDD4 OVOL2	7.38e-05	1053	29	8	GO:0000122
GeneOntologyBiologicalProcess	positive regulation of miRNA transcription	SREBF2 EGR1 AR	8.51e-05	61	29	3	GO:1902895
GeneOntologyBiologicalProcess	tube morphogenesis	HLX HOXA11 SP1 SEMA5A RBM15 AR NEDD4 OVOL2	1.17e-04	1125	29	8	GO:0035239
GeneOntologyBiologicalProcess	positive regulation of miRNA metabolic process	SREBF2 EGR1 AR	1.45e-04	73	29	3	GO:2000630
GeneOntologyBiologicalProcess	branching morphogenesis of an epithelial tube	HOXA11 SEMA5A RBM15 AR	1.62e-04	198	29	4	GO:0048754
GeneOntologyBiologicalProcess	Notch signaling pathway	SREBF2 RBM15 PRAG1 OVOL2	2.03e-04	210	29	4	GO:0007219
GeneOntologyBiologicalProcess	regulation of miRNA transcription	SREBF2 EGR1 AR	2.13e-04	83	29	3	GO:1902893
GeneOntologyBiologicalProcess	miRNA transcription	SREBF2 EGR1 AR	2.21e-04	84	29	3	GO:0061614
GeneOntologyBiologicalProcess	epithelial tube morphogenesis	HOXA11 SEMA5A RBM15 AR OVOL2	2.74e-04	421	29	5	GO:0060562
GeneOntologyBiologicalProcess	morphogenesis of a branching epithelium	HOXA11 SEMA5A RBM15 AR	3.17e-04	236	29	4	GO:0061138
GeneOntologyBiologicalProcess	embryonic digestive tract morphogenesis	HLX OVOL2	3.94e-04	21	29	2	GO:0048557
GeneOntologyBiologicalProcess	response to estrogen	HOXA11 SP1 AR	4.02e-04	103	29	3	GO:0043627
GeneOntologyBiologicalProcess	regulation of miRNA metabolic process	SREBF2 EGR1 AR	4.02e-04	103	29	3	GO:2000628
GeneOntologyBiologicalProcess	morphogenesis of a branching structure	HOXA11 SEMA5A RBM15 AR	4.44e-04	258	29	4	GO:0001763
GeneOntologyBiologicalProcess	positive regulation of epithelial cell proliferation	HLX SP1 SEMA5A AR	5.27e-04	270	29	4	GO:0050679
GeneOntologyBiologicalProcess	tube development	HLX HOXA11 SP1 SEMA5A RBM15 AR NEDD4 OVOL2	5.28e-04	1402	29	8	GO:0035295
GeneOntologyBiologicalProcess	regulation of Notch signaling pathway	SREBF2 PRAG1 OVOL2	5.41e-04	114	29	3	GO:0008593
GeneOntologyBiologicalProcess	organ induction	HOXA11 AR	6.07e-04	26	29	2	GO:0001759
GeneOntologyBiologicalProcess	trophectodermal cell differentiation	SP1 CNOT3	6.07e-04	26	29	2	GO:0001829
GeneOntologyBiologicalProcess	miRNA metabolic process	SREBF2 EGR1 AR	6.13e-04	119	29	3	GO:0010586
GeneOntologyBiologicalProcess	regulation of anatomical structure morphogenesis	HOXA11 SP1 SEMA5A LZTS3 PRAG1 AR NEDD4	6.32e-04	1090	29	7	GO:0022603
GeneOntologyBiologicalProcess	regulation of epithelial cell proliferation	HLX SP1 SEMA5A AR OVOL2	6.82e-04	514	29	5	GO:0050678
GeneOntologyBiologicalProcess	morphogenesis of an epithelial fold	AR OVOL2	7.57e-04	29	29	2	GO:0060571
GeneOntologyBiologicalProcess	regulation of animal organ formation	HOXA11 AR	9.22e-04	32	29	2	GO:0003156
GeneOntologyBiologicalProcess	embryonic digestive tract development	HLX OVOL2	1.10e-03	35	29	2	GO:0048566
GeneOntologyBiologicalProcess	cellular response to estrogen stimulus	SP1 AR	1.23e-03	37	29	2	GO:0071391
GeneOntologyBiologicalProcess	regulation of mitophagy	SREBF2 CLEC16A	1.30e-03	38	29	2	GO:1901524
GeneOntologyBiologicalProcess	epithelial cell proliferation	HLX SP1 SEMA5A AR OVOL2	1.39e-03	603	29	5	GO:0050673
GeneOntologyBiologicalProcess	embryonic organ morphogenesis	HLX HOXA11 SP1 OVOL2	1.40e-03	351	29	4	GO:0048562
GeneOntologyBiologicalProcess	specification of animal organ identity	HOXA11 AR	1.51e-03	41	29	2	GO:0010092
GeneOntologyBiologicalProcess	positive regulation of animal organ morphogenesis	HOXA11 AR	1.51e-03	41	29	2	GO:0110110
GeneOntologyBiologicalProcess	developmental induction	HOXA11 AR	1.51e-03	41	29	2	GO:0031128
GeneOntologyBiologicalProcess	positive regulation of protein-containing complex disassembly	SEMA5A CLEC16A	1.51e-03	41	29	2	GO:0043243
GeneOntologyBiologicalProcess	animal organ morphogenesis	HLX HOXA11 SP1 RBM15 AR NEDD4 OVOL2	1.55e-03	1269	29	7	GO:0009887
GeneOntologyBiologicalProcess	morphogenesis of an epithelium	HOXA11 SEMA5A RBM15 AR OVOL2	1.56e-03	619	29	5	GO:0002009
GeneOntologyBiologicalProcess	blood vessel development	SP1 SEMA5A RBM15 EGR1 NEDD4 OVOL2	1.60e-03	929	29	6	GO:0001568
GeneOntologyBiologicalProcess	placenta blood vessel development	RBM15 OVOL2	1.74e-03	44	29	2	GO:0060674
GeneOntologyBiologicalProcess	positive regulation of intracellular signal transduction	CXXC5 MAP3K10 SEMA5A PRAG1 CLEC16A AR NEDD4	1.77e-03	1299	29	7	GO:1902533
Domain	S_TKc	MAP3K10 SRPK3 TLK1 PRAG1	2.18e-03	359	29	4	SM00220
Domain	Pkinase	MAP3K10 SRPK3 TLK1 PRAG1	2.70e-03	381	29	4	PF00069
Domain	WW_DOMAIN_2	FRMPD4 NEDD4	2.83e-03	51	29	2	PS50020
Domain	WW_DOMAIN_1	FRMPD4 NEDD4	2.83e-03	51	29	2	PS01159
Domain	WW_dom	FRMPD4 NEDD4	2.94e-03	52	29	2	IPR001202
Domain	-	SP1 HIC2 EGR1 ZNF503 OVOL2	3.60e-03	679	29	5	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	SP1 HIC2 EGR1 ZNF503 OVOL2	3.95e-03	694	29	5	IPR013087
Domain	IF	KRT24 LZTS3	6.18e-03	76	29	2	IPR001664
Domain	ZINC_FINGER_C2H2_2	SP1 HIC2 EGR1 ZNF503 OVOL2	6.30e-03	775	29	5	PS50157
Domain	ZINC_FINGER_C2H2_1	SP1 HIC2 EGR1 ZNF503 OVOL2	6.37e-03	777	29	5	PS00028
Domain	Prot_kinase_dom	MAP3K10 SRPK3 TLK1 PRAG1	6.56e-03	489	29	4	IPR000719
Domain	PROTEIN_KINASE_DOM	MAP3K10 SRPK3 TLK1 PRAG1	6.75e-03	493	29	4	PS50011
Domain	Znf_C2H2-like	SP1 HIC2 EGR1 ZNF503 OVOL2	7.04e-03	796	29	5	IPR015880
Domain	Znf_C2H2	SP1 HIC2 EGR1 ZNF503 OVOL2	7.37e-03	805	29	5	IPR007087
Domain	ZnF_C2H2	SP1 HIC2 EGR1 ZNF503 OVOL2	7.49e-03	808	29	5	SM00355
Domain	Homeobox_metazoa	HLX HOXA11	8.57e-03	90	29	2	IPR020479
Domain	Kinase-like_dom	MAP3K10 SRPK3 TLK1 PRAG1	9.37e-03	542	29	4	IPR011009
Domain	Ser/Thr_kinase_AS	MAP3K10 SRPK3 TLK1	1.75e-02	357	29	3	IPR008271
Pubmed	Early growth response gene 1 modulates androgen receptor signaling in prostate carcinoma cells.	EGR1 AR	7.19e-07	2	30	2	12890669
Pubmed	Androgen induction of cyclin-dependent kinase inhibitor p21 gene: role of androgen receptor and transcription factor Sp1 complex.	SP1 AR	7.19e-07	2	30	2	10809237
Pubmed	Involvement of transcription factor Sp1 in quercetin-mediated inhibitory effect on the androgen receptor in human prostate cancer cells.	SP1 AR	7.19e-07	2	30	2	15661808
Pubmed	A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells.	AR NEDD4	2.16e-06	3	30	2	18703514
Pubmed	Reciprocal regulation of the human sterol regulatory element binding protein (SREBP)-1a promoter by Sp1 and EGR-1 transcription factors.	SP1 EGR1	2.16e-06	3	30	2	18068676
Pubmed	Nuclear receptor interaction protein, a coactivator of androgen receptors (AR), is regulated by AR and Sp1 to feed forward and activate its own gene expression through AR protein stability.	SP1 AR	2.16e-06	3	30	2	17984071
Pubmed	Tumor-mesothelium HOXA11-PDGF BB/TGF β1-miR-181a-5p-Egr1 feedforward amplifier circuity propels mesothelial fibrosis and peritoneal metastasis of gastric cancer.	HOXA11 EGR1	2.16e-06	3	30	2	37989866
Pubmed	Androgen receptor dampens tissue factor expression via nuclear factor-κB and early growth response protein 1.	EGR1 AR	2.16e-06	3	30	2	29427323
Pubmed	Specificity of transcriptional regulation by the zinc finger transcription factors Sp1, Sp3, and Egr-1.	SP1 EGR1	2.16e-06	3	30	2	15523672
Pubmed	ΗΙF1α, EGR1 and SP1 co-regulate the erythropoietin receptor expression under hypoxia: an essential role in the growth of non-small cell lung cancer cells.	SP1 EGR1	2.16e-06	3	30	2	31752873
Pubmed	Suppression of HGF receptor gene expression by oxidative stress is mediated through the interplay between Sp1 and Egr-1.	SP1 EGR1	2.16e-06	3	30	2	12569082
Pubmed	CXXC5 drove inflammation and ovarian cancer proliferation via transcriptional activation of ZNF143 and EGR1.	CXXC5 EGR1	2.16e-06	3	30	2	38642782
Pubmed	Mechanisms of platelet-activating factor-induced enhancement of VEGF expression.	SP1 EGR1	2.16e-06	3	30	2	21325822
Pubmed	Regulation of Egr-1, SRF, and Sp1 mRNA expression in contracting skeletal muscle cells.	SP1 EGR1	2.16e-06	3	30	2	15310743
Pubmed	Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation.	RBM15 SETD1B	2.16e-06	3	30	2	22927943
Pubmed	The Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene promoter is not associated with late onset Alzheimer disease.	SP1 EGR1	2.16e-06	3	30	2	18525291
Pubmed	Oxidative stress promotes transcriptional up-regulation of Fyn in BCR-ABL1-expressing cells.	SP1 EGR1	2.16e-06	3	30	2	19131339
Pubmed	Androgen receptor induces EPHA3 expression by interacting with transcription factor SP1.	SP1 AR	2.16e-06	3	30	2	29917167
Pubmed	Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b.	SP1 EGR1	2.16e-06	3	30	2	20121949
Pubmed	O-GlcNAc inhibits interaction between Sp1 and sterol regulatory element binding protein 2.	SREBF2 SP1	2.16e-06	3	30	2	20138838
Pubmed	Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms.	SP1 AR	2.16e-06	3	30	2	10617653
Pubmed	Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1.	SREBF2 SP1	2.16e-06	3	30	2	19808779
Pubmed	Egr-1 regulates the transcription of NGX6 gene through a Sp1/Egr-1 overlapping site in the promoter.	SP1 EGR1	2.16e-06	3	30	2	25029911
Pubmed	A human MAP kinase interactome.	SREBF2 MAP3K10 SP1 TLK1 NUP58 EGR1	3.23e-06	486	30	6	20936779
Pubmed	Regulated expression of the alpha isoform of the human thromboxane A2 receptor during megakaryocyte differentiation: a coordinated role for WT1, Egr1, and Sp1.	SP1 EGR1	4.31e-06	4	30	2	19747485
Pubmed	Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.	CXXC5 EGR1	4.31e-06	4	30	2	26944478
Pubmed	Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a.	SP1 EGR1	4.31e-06	4	30	2	19307576
Pubmed	Hypoxia mediates mutual repression between microRNA-27a and PPARγ in the pulmonary vasculature.	SP1 EGR1	4.31e-06	4	30	2	24244514
Pubmed	Transcription of PRDM1, the master regulator for plasma cell differentiation, depends on an SP1/SP3/EGR-1 GC-box.	SP1 EGR1	4.31e-06	4	30	2	18604866
Pubmed	Negative regulation of the Wnt signal by MM-1 through inhibiting expression of the wnt4 gene.	SP1 EGR1	4.31e-06	4	30	2	18281035
Pubmed	Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN.	AR NEDD4	4.31e-06	4	30	2	25883222
Pubmed	Egr-1 contributes to IL-1-mediated down-regulation of peroxisome proliferator-activated receptor γ expression in human osteoarthritic chondrocytes.	SP1 EGR1	4.31e-06	4	30	2	22455954
Pubmed	Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells.	SP1 EGR1	7.18e-06	5	30	2	14979875
Pubmed	Regulation of p57(KIP2) during muscle differentiation: role of Egr1, Sp1 and DNA hypomethylation.	SP1 EGR1	7.18e-06	5	30	2	18513743
Pubmed	Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors.	SP1 EGR1	7.18e-06	5	30	2	12560508
Pubmed	Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1.	SP1 AR	7.18e-06	5	30	2	16728402
Pubmed	A census of human transcription factors: function, expression and evolution.	SREBF2 HLX HOXA11 SP1 HIC2 EGR1 AR	9.73e-06	908	30	7	19274049
Pubmed	Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.	SREBF2 AR	1.51e-05	7	30	2	27137100
Pubmed	Sexual fate of murine external genitalia development: Conserved transcriptional competency for male-biased genes in both sexes.	SP1 AR	1.51e-05	7	30	2	34074765
Pubmed	Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.	SP1 AR	2.58e-05	9	30	2	9535906
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SP1 SEMA5A RBM15 CAAP1 TLK1 CNOT3	4.48e-05	774	30	6	15302935
Pubmed	Zinc finger protein genes in the mouse genome.	SP1 EGR1	4.72e-05	12	30	2	1797234
Pubmed	A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.	SREBF2 SP1	6.50e-05	14	30	2	10976766
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	SREBF2 HOXA11 SP1 EGR1 AR CNOT3	8.94e-05	877	30	6	20211142
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	SREBF2 HOXA11 SP1 EGR1 OVOL2	9.48e-05	544	30	5	28473536
Pubmed	Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.	HIC2 EGR1	1.22e-04	19	30	2	30385546
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SETD1B FRMPD4 CLEC16A NEDD4	3.98e-04	407	30	4	12693553
Pubmed	Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome.	CHIA EGR1	4.70e-04	37	30	2	22001906
Pubmed	Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.	EGR1 AR	4.96e-04	38	30	2	27930960
Pubmed	Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.	SP1 AR	5.78e-04	41	30	2	17276355
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	MAP3K10 FRMPD4 LZTS3	6.49e-04	197	30	3	36604605
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	SEMA5A CHIA NEDD4	7.81e-04	210	30	3	16537572
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MAP3K10 RBM15 SRPK3 PRAG1 NEDD4	7.83e-04	861	30	5	36931259
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	SREBF2 SP1 HIC2 RBM15 TLK1 SETD1B	8.24e-04	1327	30	6	32694731
Pubmed	Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity.	HOXA11 SEMA5A	8.25e-04	49	30	2	35315772
Interaction	EGR1 interactions	SREBF2 SP1 EGR1 NEDD4	3.83e-06	72	30	4	int:EGR1
Interaction	HDAC3 interactions	SREBF2 SP1 RBM15 CLEC16A AR OVOL2	5.80e-06	313	30	6	int:HDAC3
Interaction	CREBBP interactions	SREBF2 HOXA11 SP1 EGR1 AR CNOT3 TXNDC11	2.22e-05	599	30	7	int:CREBBP
Interaction	NR0B1 interactions	SREBF2 SP1 AR	2.83e-05	40	30	3	int:NR0B1
Interaction	SMAD3 interactions	SREBF2 CXXC5 SP1 AR NEDD4 OVOL2	4.35e-05	447	30	6	int:SMAD3
Interaction	NR5A1 interactions	SP1 EGR1 AR	9.62e-05	60	30	3	int:NR5A1
Interaction	IL1B interactions	SP1 EGR1 NEDD4	9.62e-05	60	30	3	int:IL1B
Cytoband	16p13.13	CLEC16A TXNDC11	7.79e-05	20	30	2	16p13.13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	SP1 HIC2 EGR1 ZNF503 OVOL2	1.46e-03	718	22	5	28
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SP1 SEMA5A SRPK3 PRAG1	5.35e-06	173	30	4	0a0cd40bb5f61431fe34758626c8a63ec610a8a5
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon\|organoid_Paulsen_bioRxiv / Sample Type, Dataset, Time_group, and Cell type.	CXXC5 SEMA5A EGR1 AR	8.94e-06	197	30	4	58b957efd006f43c2fe55071d5c6d06c2e367e72
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HLX HOXA11 EGR1 ZNF503	8.94e-06	197	30	4	5f6fce382f273e789ffbb75b63e9b4e87519918e
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon\|organoid_Velasco_nature / Sample Type, Dataset, Time_group, and Cell type.	CXXC5 SEMA5A EGR1 AR	9.12e-06	198	30	4	a6f65bb0845d8f64f5c7edb00cee3ca5adb1a373
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA5A DMKN AR TXNDC11	9.30e-06	199	30	4	174f6013af6eafa577f84205a62927f2b367fda3
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HLX HOXA11 EGR1 ZNF503	9.30e-06	199	30	4	bb201deb281619113edcd1de2af2d3eb21b967b8
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	CXXC5 SEMA5A EGR1 AR	9.49e-06	200	30	4	5ba4ed490c64b3bb738e7729669f893fa73aa56f
ToppCell	P15-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DMKN ODAD1 OVOL2	1.30e-04	147	30	3	aba44c7057096483c4293a7ebcf8ccc8baed0231
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SREBF2 CXXC5 RBM15	1.38e-04	150	30	3	4bdcdce40f54580c7a4e1416b468e657ba8874fc
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Plch2_Dock5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SEMA5A FRMPD4 ODAD1	1.44e-04	152	30	3	fed80b467ec9e30c7f98bed6cc4f8c583b715e9e
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_cytotoxic_T_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HIC2 RBM15 PRAG1	1.46e-04	153	30	3	df2130689e53748e820a5835fa396fe82a5d2c7c
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SEMA5A FRMPD4 ODAD1	1.76e-04	163	30	3	8d17f44faf0549fe71a9a45f811f50d767275414
ToppCell	Control-Epithelial_cells-Airway_basal\|Control / group, cell type (main and fine annotations)	SEMA5A FRMPD4 AR	2.03e-04	171	30	3	3965ced4be6db14265a90673502fceee425837ca
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SEMA5A FRMPD4 AR	2.25e-04	177	30	3	ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SEMA5A FRMPD4 AR	2.25e-04	177	30	3	cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCell	facs-Brain_Non-Myeloid-Striatum_\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT24 DMKN OVOL2	2.48e-04	183	30	3	824ecda1219fb596a01bf5cfeee29a6daa462098
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FRMPD4 EGR1 DMKN	2.48e-04	183	30	3	ec2af3402b51f11466d2a5783a6b33746b6a7fc9
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT24 DMKN OVOL2	2.48e-04	183	30	3	82b84ee065fb573688d59da97a327152a1ba294c
ToppCell	normal-na-Myeloid-plasmacytoid_dendritic_cell-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	CXXC5 SEMA5A AR	2.56e-04	185	30	3	3091870a5bf8ecb963e560b47c8502bae367416c
ToppCell	facs-BAT-Fat-24m-Epithelial-Epcam+\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXA11 KRT24 DMKN	2.60e-04	186	30	3	b18d7398279a2d42414318aeb70514fd402f5a0a
ToppCell	control-Myeloid-pDC\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CXXC5 SEMA5A AR	2.60e-04	186	30	3	fe31e9cf4575ee40b50489593c51d8c36c3cc532
ToppCell	control-Myeloid-pDC\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CXXC5 SEMA5A AR	2.60e-04	186	30	3	fccee4cfcc887358cf916d974f29627095b5ad9c
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXA11 SEMA5A DMKN	2.60e-04	186	30	3	360c3e9e5c3a943e68e6939b4a47821bfc75b553
ToppCell	saliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SETD1B PRAG1 OVOL2	2.64e-04	187	30	3	43ef900b76f3c38bd8ce9858201124130c743d56
ToppCell	saliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway-secretory_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SETD1B PRAG1 OVOL2	2.64e-04	187	30	3	6e5c38425b6b1d4774f8dcea7e146f1eab785c3e
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT24 DMKN OVOL2	2.72e-04	189	30	3	6f0fc5271a7d3682f145e734abc3be6473dda2e2
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT24 DMKN OVOL2	2.72e-04	189	30	3	3b9ce8964b16cb2200d30cbb0bfc711dcad2380e
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT24 DMKN OVOL2	2.72e-04	189	30	3	38acb307907fde68b992057714448c1561d69ee3
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA5A TLK1 NEDD4	2.77e-04	190	30	3	36e83995021ba16690f84e2077a9e8baec547d05
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA5A TLK1 NEDD4	2.77e-04	190	30	3	d26be9e1b676f750e716b91ebc3598fac3735612
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SEMA5A DMKN AR	2.77e-04	190	30	3	4f775ee24b14733f06ae40b45f2dc1a0f0df0705
ToppCell	facs-Skin\|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT24 EGR1 DMKN	2.81e-04	191	30	3	ae524103331fa53fa82888dbb567fc36abcee7e0
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGR1 AR NEDD4	2.81e-04	191	30	3	7d1595e616f6f111fc2f5bc1b179c5d67d624cc9
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SEMA5A FRMPD4 PRAG1	2.90e-04	193	30	3	000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCell	droplet-Tongue-nan-3m-Epithelial-keratinocyte\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT24 EGR1 DMKN	2.94e-04	194	30	3	592e8c4b73ba424a52305ac411ea9c0a2dc44467
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SEMA5A FRMPD4 PRAG1	2.94e-04	194	30	3	67f5e2f05a8de2213ab80d5ea16fdee121684633
ToppCell	10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-endosteal_fibroblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	HOXA11 SEMA5A DMKN	2.94e-04	194	30	3	69362e13158033de44f90f3773db6c0f27de8cb3
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Cajal_Retzius-36\|World / Primary Cells by Cluster	CXXC5 EGR1 ZNF503	2.99e-04	195	30	3	bc76a0586cc78f013cb96a2444e63e3c5daa3bc7
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SREBF2 EGR1 OVOL2	2.99e-04	195	30	3	dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Cajal_Retzius\|World / Primary Cells by Cluster	CXXC5 EGR1 ZNF503	2.99e-04	195	30	3	424d8e2bc7f7e68f74219de06dbbb671c8b4c24c
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA5A FRMPD4 AR	2.99e-04	195	30	3	6c9c58322c1df891bb4bab56dacb542c8777bb7d
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HLX HOXA11 EGR1	3.03e-04	196	30	3	fd0a2b863dedaf08d18e7f67da18ac7e853991e4
ToppCell	facs-Bladder-nan-3m\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXA11 EGR1 NEDD4	3.03e-04	196	30	3	44f5b1b474399c9316729155f2ea95a82ca66e30
ToppCell	facs-Bladder-nan-3m-Epithelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXA11 EGR1 NEDD4	3.03e-04	196	30	3	c0e90d964baa2eb4fbd18a52379ccec5d3bf59a8
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHIA EGR1 DMKN	3.08e-04	197	30	3	dea31a839de5386d6b7ead1281a6ea6b0596a855
ToppCell	Bronchial_Biopsy-Epithelial-Basal_1\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	SEMA5A EGR1 ZNF503	3.08e-04	197	30	3	a4855c5aebea4f0fed4eb035844572e82e5bac46
ToppCell	wk_20-22-Mesenchymal-Fibroblast-Airway_fibro\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	SRPK3 EGR1 ZNF503	3.08e-04	197	30	3	233caeee200ca905900226f85426e084caf290fb
ToppCell	Bronchial_Biopsy-Epithelial-Basal_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SEMA5A EGR1 ZNF503	3.08e-04	197	30	3	61c1c29a62d4c033999b7f0183c1e9cdd6a62925
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	SEMA5A EGR1 AR	3.08e-04	197	30	3	965d5a3f8c9b12cb8a8d3429702ae29ebd8c6122
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial-Astroglia\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	SEMA5A EGR1 AR	3.08e-04	197	30	3	3f088eb29197bc575400d6dafd8083e69e4a149f
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXA11 EGR1 ZNF503	3.08e-04	197	30	3	05e303fff86db31f7b742324c64980eb2b9cff9a
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma-osteoblast_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SEMA5A FRMPD4 DMKN	3.08e-04	197	30	3	2f72fd9a5b6d62c24a95ed2246194ea7458c0f12
ToppCell	mild-pDC\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CXXC5 SEMA5A AR	3.08e-04	197	30	3	15230a54fa5903dd728de1a0ad633bd2d2c7a04d
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXA11 DMKN ZNF503	3.12e-04	198	30	3	75d104eead681f6bf47c4dd24913cc768c9a1717
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EGR1 PRAG1 NEDD4	3.12e-04	198	30	3	0993d6895c0e4f360998ce35abea4ec3dd13e048
ToppCell	Control-B_intermediate-0\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	CXXC5 TLK1 EGR1	3.12e-04	198	30	3	97e66b845053201247e2241739328cd73f33975c
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CXXC5 HLX EGR1	3.12e-04	198	30	3	7b61f427ed5ca8ad563e5f112fba950a24c9d956
ToppCell	AT2_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	CHIA NUP58 EGR1	3.12e-04	198	30	3	893036558a9ad86b57f9e735df35812e9d18739e
ToppCell	Transverse-(2)_B_cell-(21)_B_cell_IgG_Plasma\|Transverse / shred on region, Cell_type, and subtype	CXXC5 CHIA TXNDC11	3.12e-04	198	30	3	d6052b5a44246798e90f4779cd940ffac7539fcd
ToppCell	Transverse-B_cell-B_cell_IgG_Plasma\|Transverse / Region, Cell class and subclass	CXXC5 CHIA TXNDC11	3.12e-04	198	30	3	a4ece1fe3d15acfde0e6ff14cddb3a3d16f61ce0
ToppCell	mild-HLA-DR-_S100A+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HLX EGR1 ZNF503	3.17e-04	199	30	3	d0d286eafe935f9b3aaba5b783e8911251121b4a
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HLX HOXA11 ZNF503	3.17e-04	199	30	3	a95aa72387c9558e0316898eaa9df4de8932af1b
ToppCell	Sepsis-URO-Lymphocyte-T/NK-CD8+_Tcm\|URO / Disease, condition lineage and cell class	SEMA5A DMKN ODAD1	3.17e-04	199	30	3	eb085f9f2c837494548c26bb61e8b74516539e23
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Macroglial-Glia_progenitor_cell\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	CXXC5 SRPK3 AR	3.22e-04	200	30	3	0b91c8da21ba488109f15c9b927c1dcaf8c6b0ae
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA5A EGR1 DMKN	3.22e-04	200	30	3	ea1325ca6039c6d2318b1ceb9d396399bb21b670
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-OPC_related-Oligodendrocyte/OPC\|10w / Sample Type, Dataset, Time_group, and Cell type.	CXXC5 CAAP1 PRAG1	3.22e-04	200	30	3	345f1eac498cc87fd7bf08e7312608b2d6fe1dd7
ToppCell	severe-Classical_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HLX EGR1 ZNF503	3.22e-04	200	30	3	f46689940fdea500ce2457eec412dd2c46705819
ToppCell	mild-NK_CD56bright\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CXXC5 HOXA11 DMKN	3.22e-04	200	30	3	6de701985a0b92a7dece1b0e4a76e13756ccc0dd
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-OPC_related\|10w / Sample Type, Dataset, Time_group, and Cell type.	CXXC5 CAAP1 PRAG1	3.22e-04	200	30	3	8f5d98f962ddd8c4658c89ff8a2894de1228562a
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_basal-Basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA5A EGR1 DMKN	3.22e-04	200	30	3	8c8a631b9892f6594857a27e020b43aae3afcaac
ToppCell	mild-HLA-DR-_S100A+_Monocyte\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HLX EGR1 ZNF503	3.22e-04	200	30	3	6dd89835a9f7bebb4849cff8eecb82caf6e1acbf
Drug	Helveticoside [630-64-8]; Up 200; 7.4uM; MCF7; HT_HG-U133A	SP1 HIC2 NUP58 EGR1 OVOL2	2.32e-06	165	30	5	3851_UP
Drug	Ethisterone [434-03-7]; Up 200; 12.8uM; PC3; HT_HG-U133A	SP1 SEMA5A SRPK3 TLK1 AR	5.11e-06	194	30	5	3783_UP
Drug	Probucol [23288-49-5]; Up 200; 7.8uM; MCF7; HT_HG-U133A	SP1 TLK1 SETD1B EGR1 CNOT3	5.65e-06	198	30	5	3223_UP
Drug	AC1L5326	SP1 EGR1	1.67e-05	5	30	2	CID000169064
Drug	2,4,6-trichlorophenyl 4-nitrophenyl ether	EGR1 AR	3.51e-05	7	30	2	ctd:C010422
Drug	5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione	SP1 AR	4.68e-05	8	30	2	ctd:C513003
Drug	Proscillaridin A [466-06-8]; Up 200; 7.6uM; MCF7; HT_HG-U133A	HIC2 RBM15 NUP58 EGR1	5.86e-05	162	30	4	7340_UP
Drug	Strophanthidin [66-28-4]; Up 200; 9.8uM; HL60; HT_HG-U133A	SP1 RBM15 NUP58 EGR1	6.44e-05	166	30	4	2525_UP
Drug	Strophantine octahydrate [11018-89-6]; Up 200; 5.4uM; PC3; HT_HG-U133A	HIC2 TLK1 NUP58 EGR1	6.59e-05	167	30	4	6680_UP
Drug	Strophantine octahydrate [11018-89-6]; Up 200; 5.4uM; MCF7; HT_HG-U133A	SP1 HIC2 RBM15 EGR1	7.23e-05	171	30	4	5026_UP
Drug	chlornitrofen	EGR1 AR	7.50e-05	10	30	2	CID000015788
Drug	Strophantine octahydrate [11018-89-6]; Up 200; 5.4uM; HL60; HT_HG-U133A	HIC2 RBM15 NUP58 EGR1	7.73e-05	174	30	4	1302_UP
Drug	0175029-0000 [211245-78-2]; Up 200; 1uM; MCF7; HT_HG-U133A	HIC2 RBM15 LZTS3 EGR1	8.44e-05	178	30	4	4716_UP
Drug	Decamethonium bromide [541-22-0]; Down 200; 9.6uM; PC3; HT_HG-U133A	SREBF2 SEMA5A HIC2 EGR1	1.11e-04	191	30	4	4094_DN
Drug	Domperidone maleate; Up 200; 7.4uM; PC3; HT_HG-U133A	SP1 SEMA5A HIC2 CNOT3	1.11e-04	191	30	4	4640_UP
Drug	Nitrofural [59-87-0]; Down 200; 20.2uM; MCF7; HT_HG-U133A	SREBF2 SP1 TLK1 LZTS3	1.20e-04	195	30	4	3320_DN
Drug	Pancuronium bromide [15500-66-0]; Down 200; 5.4uM; MCF7; HT_HG-U133A	SP1 TLK1 KRT24 LZTS3	1.20e-04	195	30	4	4393_DN
Drug	Piperacillin sodium salt [59703-84-3]; Up 200; 7.4uM; PC3; HT_HG-U133A	SREBF2 HIC2 KRT24 EGR1	1.22e-04	196	30	4	3763_UP
Drug	Sulfadimethoxine [122-11-2]; Up 200; 12.8uM; MCF7; HT_HG-U133A	SREBF2 KRT24 SETD1B LZTS3	1.22e-04	196	30	4	4724_UP
Drug	alpha-Santonin [481-06-1]; Up 200; 16.2uM; MCF7; HT_HG-U133A	HOXA11 SEMA5A KRT24 EGR1	1.25e-04	197	30	4	3877_UP
Drug	Bupropion hydrochloride [31677-93-7]; Up 200; 14.4uM; MCF7; HT_HG-U133A	SP1 HIC2 LZTS3 EGR1	1.30e-04	199	30	4	6256_UP
Drug	Gly-His-Lys acetate salt; Down 200; 1uM; PC3; HT_HG-U133A	SREBF2 HLX HIC2 AR	1.30e-04	199	30	4	6560_DN
Drug	Ethoxyquin [91-53-2]; Up 200; 18.4uM; PC3; HT_HG-U133A	SP1 SEMA5A HIC2 TLK1	1.30e-04	199	30	4	3764_UP
Drug	Aminophylline [317-34-0]; Down 200; 9.6uM; MCF7; HT_HG-U133A	SP1 HIC2 TLK1 CLEC16A	1.32e-04	200	30	4	5395_DN
Drug	PHA-00851261E [724719-49-7]; Up 200; 1uM; PC3; HT_HG-U133A	SP1 HIC2 TLK1 EGR1	1.32e-04	200	30	4	3776_UP
Drug	Carbachol [51-83-2]; Down 200; 21.8uM; MCF7; HT_HG-U133A	SREBF2 HIC2 TLK1 KRT24	1.32e-04	200	30	4	3380_DN
Drug	Promazine hydrochloride [53-60-1]; Up 200; 12.4uM; MCF7; HT_HG-U133A	HOXA11 SP1 SETD1B EGR1	1.32e-04	200	30	4	3833_UP
Drug	Tobramycin [32986-56-4]; Up 200; 8.6uM; HL60; HT_HG-U133A	HIC2 KRT24 SETD1B LZTS3	1.32e-04	200	30	4	2481_UP
Drug	Bendroflumethiazide [73-48-3]; Up 200; 9.4uM; PC3; HT_HG-U133A	TLK1 KRT24 EGR1 CNOT3	1.32e-04	200	30	4	3758_UP
Drug	Chloroprene	HLX SP1 SRPK3 TLK1 EGR1 DMKN AR NEDD4	2.68e-04	1348	30	8	ctd:D002737
Drug	AC1L3USJ	SREBF2 CHIA	3.47e-04	21	30	2	CID000122544
Drug	glyphosate	SREBF2 SEMA5A EGR1 AR TXNDC11	3.72e-04	479	30	5	ctd:C010974
Drug	deoxynivalenol	SP1 RBM15 EGR1 AR TXNDC11	3.80e-04	481	30	5	ctd:C007262
Drug	mibolerone	SP1 AR	4.55e-04	24	30	2	ctd:C100075
Drug	A25618	HOXA11 SP1 HIC2 EGR1 AR CNOT3	4.56e-04	777	30	6	CID000005562
Drug	NSC 93128	EGR1 AR	5.35e-04	26	30	2	CID000073511
Drug	aurin	EGR1 AR	6.21e-04	28	30	2	ctd:C017037
Drug	Estriol	HOXA11 EGR1 AR	6.31e-04	128	30	3	ctd:D004964
Drug	Betamethasone	EGR1 AR	6.67e-04	29	30	2	ctd:D001623
Drug	Nimodipine	EGR1 AR	7.62e-04	31	30	2	ctd:D009553
Drug	pyrazolanthrone	SREBF2 SP1 EGR1 AR	8.05e-04	322	30	4	ctd:C432165
Drug	4,4'-hexafluorisopropylidene diphenol	SEMA5A EGR1 AR	8.52e-04	142	30	3	ctd:C583074
Drug	Proadifen	EGR1 AR	9.17e-04	34	30	2	ctd:D011335
Drug	AH 23848	SP1 EGR1	9.17e-04	34	30	2	ctd:C046926
Drug	Benzalkonium Compounds	SREBF2 EGR1	9.17e-04	34	30	2	ctd:D001548
Drug	6-isopropoxy-9-oxoxanthene-2-carboxylic acid	SP1 EGR1	1.09e-03	37	30	2	ctd:C053876
Drug	Arg-Asp	SP1 EGR1	1.09e-03	37	30	2	CID006426948
Drug	Helveticoside [630-64-8]; Up 200; 7.4uM; HL60; HT_HG-U133A	RBM15 NUP58 EGR1	1.18e-03	159	30	3	2192_UP
Drug	Proscillaridin A [466-06-8]; Up 200; 7.6uM; MCF7; HT_HG-U133A	HIC2 NUP58 EGR1	1.20e-03	160	30	3	4404_UP
Drug	resibufogenin	SP1 AR	1.21e-03	39	30	2	CID000010063
Drug	ginsenoside Rg3	SP1 AR	1.21e-03	39	30	2	ctd:C097367
Drug	cupric chloride	SP1 SEMA5A EGR1 AR ZNF503	1.22e-03	623	30	5	ctd:C029892
Drug	Lanatoside C [17575-22-3]; Up 200; 4uM; PC3; HT_HG-U133A	HIC2 NUP58 EGR1	1.25e-03	162	30	3	3771_UP
Drug	Digitoxigenin [143-62-4]; Up 200; 10.6uM; HL60; HT_HG-U133A	RBM15 NUP58 EGR1	1.25e-03	162	30	3	1339_UP
Drug	roscovitine	SP1 EGR1	1.27e-03	40	30	2	ctd:C104586
Drug	Lanatoside C [17575-22-3]; Up 200; 4uM; MCF7; HT_HG-U133A	HIC2 EGR1 OVOL2	1.29e-03	164	30	3	3852_UP
Drug	Proscillaridin A [466-06-8]; Up 200; 7.6uM; HL60; HT_HG-U133A	RBM15 NUP58 EGR1	1.29e-03	164	30	3	2920_UP
Drug	Digitoxigenin [143-62-4]; Up 200; 10.6uM; MCF7; HT_HG-U133A	HIC2 NUP58 EGR1	1.31e-03	165	30	3	3275_UP
Disease	silicosis (biomarker_via_orthology)	CHIA EGR1	8.43e-05	14	29	2	DOID:10325 (biomarker_via_orthology)
Disease	lateral ventricle volume measurement	SEMA5A CLEC16A	4.83e-04	33	29	2	EFO_0008487
Disease	Neoplasm Recurrence, Local	TLK1 AR	6.76e-04	39	29	2	C0027643
Disease	Insulin Sensitivity	SREBF2 AR	1.59e-03	60	29	2	C0920563
Disease	Insulin Resistance	SREBF2 AR	1.59e-03	60	29	2	C0021655
Disease	mitochondrial heteroplasmy measurement	CLEC16A OVOL2	2.10e-03	69	29	2	EFO_0600008
Disease	type 1 diabetes mellitus (is_implicated_in)	SREBF2 CLEC16A	3.17e-03	85	29	2	DOID:9744 (is_implicated_in)
Disease	visual epilepsy (biomarker_via_orthology)	SREBF2 EGR1	3.54e-03	90	29	2	DOID:11832 (biomarker_via_orthology)
Disease	Parkinson disease	SP1 SEMA5A LZTS3	3.78e-03	321	29	3	MONDO_0005180
Disease	lower face morphology measurement	HLX PRAG1	5.14e-03	109	29	2	EFO_0010948
Disease	prostate cancer (is_implicated_in)	SREBF2 AR	5.90e-03	117	29	2	DOID:10283 (is_implicated_in)
Disease	asthma	KRT24 PRAG1 CLEC16A LCE1D	5.96e-03	751	29	4	MONDO_0004979
Disease	smoking behavior, BMI-adjusted waist circumference	HLX HOXA11	6.40e-03	122	29	2	EFO_0004318, EFO_0007789
Disease	acne	PRAG1 CLEC16A	6.71e-03	125	29	2	EFO_0003894
Disease	asthma (is_marker_for)	CHIA EGR1	6.81e-03	126	29	2	DOID:2841 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GSSSSGGSSGGSGFC	CHIA	416	Q9BZP6
ASGGACSAASSASGG	BTBD11	296	A6QL63
ALASGSSGSTSGCGS	CAAP1	31	Q9H8G2
GGSSSSSNSSAGGGA	CNOT3	406	O75175
GSGGSNGSSSGKTDS	RBM15	76	Q96T37
VDCGGSSSGSSSGGS	MAP3K10	521	Q02779
VGSSGGSSSSGGSDK	LZTS3	116	O60299
STSAGCASSLGGGGA	HLX	446	Q14774
GSDFGSCASITSGGS	NEDD4	166	P46934
EGSGSNSSSSSSGGG	EGR1	56	P18146
GASSCSLSGGSSGAF	KRT24	46	Q2M2I5
GCSGSAAAGSSGTLE	AR	326	P10275
APATSSSDSGGGGGC	HOXA11	186	P31270
DCRSDGGSSSGSGSS	OVOL2	46	Q9BRP0
SGGTASDSSGGLGSS	ODAD1	631	Q96M63
AGGSSSSSTNGSGGS	CXXC5	11	Q7LFL8
SSNSGGGSGSQSGSS	DMKN	241	Q6E0U4
SSVDAGCGTGSSGSA	FRMPD4	1216	Q14CM0
SVSSGGCCGSSSGGG	LCE1D	41	Q5T752
SSGFGCSTTGASTFG	NUP58	516	Q9BVL2
GLGGCSSSTNGSSGG	HIC2	226	Q96JB3
CGSGSSSVTPNSGGT	SETD1B	236	Q9UPS6
SSTGSSSSTGGGGQE	SP1	41	P08047
SSDGTSGCSTDGLSG	SEMA5A	756	Q13591
SGGSGGSSSSSQASC	SRPK3	11	Q9UPE1
GSPSGSGSTSHCDSG	CLEC16A	906	Q2KHT3
ASGSTGSTGSCSVGA	TLK1	71	Q9UKI8
CSSFPGSGGSGSSSG	SREBF2	51	Q12772
ISSDGLSCGSGSGSG	PRAG1	336	Q86YV5
LSCGSGSGSGSGASS	PRAG1	341	Q86YV5
MSECGGRGGGSSSSE	TXNDC11	1	Q6PKC3
ALGSDCGGSSGSSSG	ZNF503	306	Q96F45
CGGSSGSSSGSGPSA	ZNF503	311	Q96F45