Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransporter activity

SLC6A8 ATP13A4 HTR3A SLC5A6 MCU TRPC6 PKD2 ANO1 TMEM266 ATP9B CACNG5 ATP8B1 XKR4 ITGAV SLC9C2 LMBRD1 CIDEA

7.71e-0612897817GO:0005215
GeneOntologyMolecularFunctionnicotinic acid receptor activity

HCAR3 HCAR2

1.51e-052782GO:0070553
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

ATP13A4 MCU TRPC6 PKD2 CACNG5 ITGAV

2.78e-05151786GO:0015085
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ANO1 ATP9B ATP8B1 XKR4

4.68e-0551784GO:0140303
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC6A8 ATP13A4 HTR3A SLC5A6 MCU TRPC6 PKD2 ANO1 CACNG5 ITGAV SLC9C2

5.20e-056647811GO:0008324
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC6A8 ATP13A4 HTR3A SLC5A6 MCU TRPC6 PKD2 ANO1 TMEM266 CACNG5 ITGAV SLC9C2

5.53e-057937812GO:0015075
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC6A8 ATP13A4 SLC5A6 MCU TRPC6 PKD2 CACNG5 ITGAV SLC9C2

8.19e-05465789GO:0046873
GeneOntologyMolecularFunctioniodide transmembrane transporter activity

SLC5A6 ANO1

1.49e-045782GO:0015111
GeneOntologyMolecularFunctioncalcium channel activity

MCU TRPC6 PKD2 CACNG5 ITGAV

1.51e-04129785GO:0005262
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR2M4 OR2W3 HCAR3 HCAR2 OR2M2 MLNR OR11H4 OR2T7 OR2T1 OR1A2 GCGR ACKR4

1.55e-048847812GO:0004930
GeneOntologyMolecularFunctiondihydropyrimidinase activity

DPYSL3 CRMP1

2.24e-046782GO:0004157
GeneOntologyMolecularFunctionmonoatomic cation channel activity

HTR3A MCU TRPC6 PKD2 ANO1 CACNG5 ITGAV

3.86e-04343787GO:0005261
GeneOntologyMolecularFunctionmonoatomic ion channel activity

HTR3A MCU TRPC6 PKD2 ANO1 TMEM266 CACNG5 ITGAV

4.21e-04459788GO:0005216
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

EPHB2 OR2M4 OR2W3 HCAR3 HCAR2 HTR3A OR2M2 MLNR OR11H4 OR2T7 OR2T1 OR1A2 GCGR ACKR4

6.86e-0413537814GO:0004888
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC6A8 ATP13A4 SLC5A6 MCU TRPC6 PKD2 ANO1 CACNG5 ITGAV SLC9C2

7.15e-047587810GO:0015318
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC6A8 ATP13A4 SLC5A6 MCU TRPC6 PKD2 CACNG5 ITGAV SLC9C2

7.42e-04627789GO:0022890
GeneOntologyMolecularFunctionvoltage-gated channel activity

PKD2 ANO1 TMEM266 CACNG5 ITGAV

7.71e-04184785GO:0022832
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

PKD2 CACNG5 ITGAV

7.71e-0446783GO:0005245
GeneOntologyMolecularFunctionchannel activity

HTR3A MCU TRPC6 PKD2 ANO1 TMEM266 CACNG5 ITGAV

1.01e-03525788GO:0015267
GeneOntologyMolecularFunctionlipid transporter activity

ANO1 ATP9B ATP8B1 XKR4 CIDEA

1.02e-03196785GO:0005319
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

HTR3A MCU TRPC6 PKD2 ANO1 TMEM266 CACNG5 ITGAV

1.02e-03526788GO:0022803
GeneOntologyMolecularFunctionolfactory receptor activity

OR2M4 OR2W3 OR2M2 OR11H4 OR2T7 OR2T1 OR1A2

1.47e-03431787GO:0004984
GeneOntologyMolecularFunctionmonocarboxylate:sodium symporter activity

SLC6A8 SLC5A6

1.53e-0315782GO:0140161
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

DPYSL3 CRMP1

1.74e-0316782GO:0016812
GeneOntologyMolecularFunctiongated channel activity

HTR3A PKD2 ANO1 TMEM266 CACNG5 ITGAV

1.96e-03334786GO:0022836
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC6A8 ATP13A4 HTR3A SLC5A6 MCU TRPC6 PKD2 ANO1 TMEM266 CACNG5 ITGAV SLC9C2

2.00e-0311807812GO:0022857
GeneOntologyMolecularFunctionsecondary active monocarboxylate transmembrane transporter activity

SLC6A8 SLC5A6

2.47e-0319782GO:0015355
GeneOntologyMolecularFunctionphospholipid transporter activity

ANO1 ATP8B1 XKR4

3.05e-0374783GO:0005548
GeneOntologyMolecularFunctionnucleotide receptor activity

HCAR3 HCAR2

3.31e-0322782GO:0016502
GeneOntologyMolecularFunctionpurinergic nucleotide receptor activity

HCAR3 HCAR2

3.31e-0322782GO:0001614
GeneOntologyMolecularFunctionphospholipid scramblase activity

ANO1 XKR4

3.61e-0323782GO:0017128
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC6A8 SLC5A6 PKD2 SLC9C2

4.53e-03171784GO:0015081
GeneOntologyCellularComponentintraciliary transport particle A

TTC21A TTC21B

3.79e-048782GO:0030991
GeneOntologyCellularComponentcytoplasmic stress granule

PUM2 LARP1B PUM1 KPNB1

4.59e-0496784GO:0010494
GeneOntologyCellularComponentmonoatomic ion channel complex

HTR3A CPT1C MCU TRPC6 PKD2 ANO1 CACNG5

5.25e-04378787GO:0034702
DomainHCAR2/3_rcpt

HCAR3 HCAR2

1.63e-052762IPR028017
DomainPumilio_RNA-bd

PUM2 PUM1

1.63e-052762IPR033712
DomainPUM-HD

PUM2 PUM1

4.89e-053762IPR033133
DomainPUF

PUM2 PUM1

4.89e-053762PF00806
DomainPUM_HD

PUM2 PUM1

4.89e-053762PS50303
DomainPumilio_RNA-bd_rpt

PUM2 PUM1

9.75e-054762IPR001313
DomainPUM

PUM2 PUM1

9.75e-054762PS50302
DomainPumilio

PUM2 PUM1

9.75e-054762SM00025
DomainTMEM14

TMEM14B TMEM14DP

1.62e-045762IPR005349
DomainTmemb_14

TMEM14B TMEM14DP

1.62e-045762PF03647
DomainHydantoinase/dihydroPyrase

DPYSL3 CRMP1

2.43e-046762IPR011778
Domain-

ATP13A4 ATP9B ATP8B1

2.95e-04327633.40.1110.10
Domain-

ATP13A4 ATP9B ATP8B1

2.95e-04327632.70.150.10
DomainTPR-contain_dom

CRNKL1 TTC21A TTC21B ZMYND12 LRP2BP

3.65e-04150765IPR013026
DomainGPCR_Rhodpsn_7TM

OR2M4 OR2W3 HCAR3 HCAR2 OR2M2 MLNR OR11H4 OR2T1 OR1A2 ACKR4

3.72e-046707610IPR017452
DomainATPase_P-typ_cyto_domN

ATP13A4 ATP9B ATP8B1

3.86e-0435763IPR023299
Domain7tm_1

OR2M4 OR2W3 HCAR3 HCAR2 OR2M2 MLNR OR11H4 OR2T1 OR1A2 ACKR4

4.04e-046777610PF00001
DomainP_typ_ATPase

ATP13A4 ATP9B ATP8B1

4.20e-0436763IPR001757
DomainATPase_P-typ_P_site

ATP13A4 ATP9B ATP8B1

4.20e-0436763IPR018303
DomainATPASE_E1_E2

ATP13A4 ATP9B ATP8B1

4.20e-0436763PS00154
DomainG_PROTEIN_RECEP_F1_1

OR2M4 OR2W3 HCAR3 HCAR2 OR2M2 MLNR OR11H4 OR2T1 OR1A2 ACKR4

4.43e-046857610PS00237
Domain-

DPYSL3 CRMP1

4.50e-0487622.30.40.10
DomainATPase_P-typ_transduc_dom_A

ATP13A4 ATP9B ATP8B1

4.55e-0437763IPR008250
DomainE1-E2_ATPase

ATP13A4 ATP9B ATP8B1

4.55e-0437763PF00122
DomainG_PROTEIN_RECEP_F1_2

OR2M4 OR2W3 HCAR3 HCAR2 OR2M2 MLNR OR11H4 OR2T1 OR1A2 ACKR4

4.74e-046917610PS50262
DomainGPCR_Rhodpsn

OR2M4 OR2W3 HCAR3 HCAR2 OR2M2 MLNR OR11H4 OR2T1 OR1A2 ACKR4

4.80e-046927610IPR000276
DomainAmidohydro_1

DPYSL3 CRMP1

7.20e-0410762PF01979
DomainMetal-dep_hydrolase_composite

DPYSL3 CRMP1

7.20e-0410762IPR011059
DomainAmidohydro-rel

DPYSL3 CRMP1

8.78e-0411762IPR006680
DomainP_typ_ATPase_c

ATP9B ATP8B1

1.44e-0314762IPR032630
DomainP-type_ATPase_N

ATP9B ATP8B1

1.44e-0314762IPR032631
DomainP-type_ATPase_IV

ATP9B ATP8B1

1.44e-0314762IPR006539
DomainPhoLip_ATPase_C

ATP9B ATP8B1

1.44e-0314762PF16212
DomainPhoLip_ATPase_N

ATP9B ATP8B1

1.44e-0314762PF16209
Domain-

CRNKL1 TTC21A TTC21B ZMYND12 LRP2BP

1.56e-032077651.25.40.10
DomainChannel_four-helix_dom

PKD2 TMEM266 SLC9C2

1.62e-0357763IPR027359
Domain-

PKD2 TMEM266 SLC9C2

1.62e-03577631.20.120.350
Domain-

ATP13A4 ATP9B ATP8B1

2.26e-03647633.40.50.1000
DomainTPR-like_helical_dom

CRNKL1 TTC21A TTC21B ZMYND12 LRP2BP

2.61e-03233765IPR011990
Domainzf-MYND

SMYD1 ZMYND12

3.26e-0321762PF01753
DomainZnf_MYND

SMYD1 ZMYND12

3.58e-0322762IPR002893
DomainZF_MYND_1

SMYD1 ZMYND12

3.58e-0322762PS01360
DomainZF_MYND_2

SMYD1 ZMYND12

3.58e-0322762PS50865
DomainHAD-like_dom

ATP13A4 ATP9B ATP8B1

4.10e-0379763IPR023214
DomainMetal_Hydrolase

DPYSL3 CRMP1

4.26e-0324762IPR032466
DomainTPR_REGION

TTC21A TTC21B ZMYND12 LRP2BP

4.60e-03165764PS50293
DomainTPR

TTC21A TTC21B ZMYND12 LRP2BP

4.60e-03165764PS50005
DomainOlfact_rcpt

OR2M4 OR2W3 OR2M2 OR11H4 OR2T1 OR1A2

5.29e-03393766IPR000725
Pubmed

CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain.

DPYSL3 CRMP1

4.97e-06278227836492
Pubmed

Axonal morphogenesis controlled by antagonistic roles of two CRMP subtypes in microtubule organization.

DPYSL3 CRMP1

4.97e-06278212814366
Pubmed

Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization.

HCAR3 HCAR2

4.97e-06278228186140
Pubmed

Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis.

TTC21A TTC21B

4.97e-06278232167205
Pubmed

The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation.

HCAR3 HCAR2

4.97e-06278230154797
Pubmed

The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival.

HCAR3 HCAR2

4.97e-06278224371223
Pubmed

High dietary niacin may increase prostaglandin formation but does not increase tumor formation in ApcMin/+ mice.

HCAR3 HCAR2

4.97e-06278221774590
Pubmed

The role of HCA2 (GPR109A) in regulating macrophage function.

HCAR3 HCAR2

4.97e-06278223882124
Pubmed

Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model.

HCAR3 HCAR2

4.97e-06278236891315
Pubmed

GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes.

HCAR3 HCAR2

4.97e-06278236208084
Pubmed

Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a.

HCAR3 HCAR2

4.97e-06278238007572
Pubmed

The role of the C-terminus of the human hydroxycarboxylic acid receptors 2 and 3 in G protein activation using Gα-engineered yeast cells.

HCAR3 HCAR2

4.97e-06278226656756
Pubmed

Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.

HCAR3 HCAR2

4.97e-06278237597514
Pubmed

Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.

PUM2 PUM1

4.97e-06278212459267
Pubmed

The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism.

HCAR3 HCAR2

4.97e-06278233924461
Pubmed

Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE.

HCAR3 HCAR2

4.97e-06278224691444
Pubmed

Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.

PUM2 PUM1

4.97e-06278229165587
Pubmed

Ketone Body 3-Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a-Mediated Calcium Influx.

HCAR3 HCAR2

4.97e-06278233977048
Pubmed

Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms.

HCAR3 HCAR2

4.97e-06278231347703
Pubmed

PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily.

HCAR3 HCAR2

4.97e-06278211745392
Pubmed

Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis.

HCAR3 HCAR2

4.97e-06278230659164
Pubmed

Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets.

HCAR3 HCAR2

4.97e-06278225622782
Pubmed

PUMILIO-mediated translational control of somatic cell cycle program promotes folliculogenesis and contributes to ovarian cancer progression.

PUM2 PUM1

4.97e-06278235507203
Pubmed

Bespoke RNA recognition by Pumilios.

PUM2 PUM1

4.97e-06278226517885
Pubmed

GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice.

HCAR3 HCAR2

4.97e-06278233420329
Pubmed

Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium.

HCAR3 HCAR2

4.97e-06278219223991
Pubmed

Mouse Pum1 and Pum2 genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal and adult hematopoietic stem cells and progenitors.

PUM2 PUM1

4.97e-06278212667987
Pubmed

Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer.

PUM2 PUM1

4.97e-06278212771951
Pubmed

Molecular identification of nicotinic acid receptor.

HCAR3 HCAR2

4.97e-06278212646212
Pubmed

PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.

HCAR3 HCAR2

4.97e-06278212563315
Pubmed

Alternate modes of cognate RNA recognition by human PUMILIO proteins.

PUM2 PUM1

4.97e-06278221397187
Pubmed

Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.

HCAR3 HCAR2

4.97e-06278223967184
Pubmed

Involvement of the Niacin Receptor GPR109a in the LocalControl of Glucose Uptake in Small Intestine of Type 2Diabetic Mice.

HCAR3 HCAR2

4.97e-06278226371038
Pubmed

Alloreactive T cells deficient of the short-chain fatty acid receptor GPR109A induce less graft-versus-host disease.

HCAR3 HCAR2

4.97e-06278234653248
Pubmed

Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G).

HCAR3 HCAR2

4.97e-06278219136666
Pubmed

G Protein-Coupled Receptor 109A Maintains the Intestinal Integrity and Protects Against ETEC Mucosal Infection by Promoting IgA Secretion.

HCAR3 HCAR2

4.97e-06278233488584
Pubmed

Lactate-induced activation of HCA2 improves survival in mice with sepsis.

HCAR3 HCAR2

4.97e-06278230951370
Pubmed

Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet.

HCAR3 HCAR2

4.97e-06278231858105
Pubmed

Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock.

HCAR3 HCAR2

4.97e-06278230625381
Pubmed

Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy.

HCAR3 HCAR2

4.97e-06278232068460
Pubmed

The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.

HCAR3 HCAR2

4.97e-06278230657794
Pubmed

Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.

HCAR3 HCAR2

4.97e-06278230085883
Pubmed

Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation.

HCAR3 HCAR2

4.97e-06278221655214
Pubmed

Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.

HCAR3 HCAR2

4.97e-06278234092246
Pubmed

(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.

HCAR3 HCAR2

4.97e-06278215929991
Pubmed

A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins.

PUM2 PUM1

4.97e-06278231078383
Pubmed

Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.

HCAR3 HCAR2

4.97e-06278236991440
Pubmed

Inflammation stimulates niacin receptor (GPR109A/HCA2) expression in adipose tissue and macrophages.

HCAR3 HCAR2

4.97e-06278225320346
Pubmed

Molecular identification of high and low affinity receptors for nicotinic acid.

HCAR3 HCAR2

4.97e-06278212522134
Pubmed

Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis.

PUM2 PUM1

4.97e-06278232753408
Pubmed

Nicotinic acid inhibits glucose-stimulated insulin secretion via the G protein-coupled receptor PUMA-G in murine islet β cells.

HCAR3 HCAR2

4.97e-06278221441844
Pubmed

G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis.

HCAR3 HCAR2

4.97e-06278230271409
Pubmed

Genetic Interaction of Thm2 and Thm1 Shapes Postnatal Craniofacial Bone.

TTC21A TTC21B

4.97e-06278235645293
Pubmed

Niacin fine-tunes energy homeostasis through canonical GPR109A signaling.

HCAR3 HCAR2

4.97e-06278230596513
Pubmed

The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease.

HCAR3 HCAR2

4.97e-06278235320002
Pubmed

GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing.

HCAR3 HCAR2

4.97e-06278216322797
Pubmed

PUMILIO proteins promote colorectal cancer growth via suppressing p21.

PUM2 PUM1

4.97e-06278235338151
Pubmed

BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease.

HCAR3 HCAR2

4.97e-06278231914599
Pubmed

Nicotinic acid receptor agonists.

HCAR3 HCAR2

4.97e-06278218983141
Pubmed

Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms.

HCAR3 HCAR2

4.97e-06278231366236
Pubmed

Effects of PUMILIO1 and PUMILIO2 knockdown on cardiomyogenic differentiation of human embryonic stem cells culture.

PUM2 PUM1

4.97e-06278232437472
Pubmed

N-myc downstream-regulated gene 1 is involved in the regulation of cystogenesis in transgenic mice overexpressing human PKD2 gene.

NDRG1 PKD2

4.97e-06278223212942
Pubmed

Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes.

HCAR3 HCAR2

4.97e-06278220655299
Pubmed

Evidence for constitutive dimerization of niacin receptor subtypes.

HCAR3 HCAR2

4.97e-06278220380810
Pubmed

GPR109A Expression in the Murine Min6 Pancreatic Beta Cell Line, and Its Relation with Glucose Metabolism and Inflammation.

HCAR3 HCAR2

4.97e-06278226116596
Pubmed

Expression and activation of the ketone body receptor HCAR2/GPR109A promotes preservation of retinal endothelial cell barrier function.

HCAR3 HCAR2

4.97e-06278235649469
Pubmed

GPR109A expressed on medullary thymic epithelial cells affects thymic Treg development.

HCAR3 HCAR2

4.97e-06278237595951
Pubmed

The hypophagic response to heat stress is not mediated by GPR109A or peripheral β-OH butyrate.

HCAR3 HCAR2

4.97e-06278226936786
Pubmed

Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response.

HCAR3 HCAR2

4.97e-06278234084164
Pubmed

Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system.

PUM2 PUM1

4.97e-06278218776931
Pubmed

GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice.

HCAR3 HCAR2

4.97e-06278235489706
Pubmed

Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model.

PUM2 PUM1

4.97e-06278232316190
Pubmed

Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis.

HCAR3 HCAR2

4.97e-06278219561068
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR2M4 OR2W3 OR2M2 OR2T7 OR2T1 OR1A2

1.02e-0521978612213199
Pubmed

Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth.

HCAR3 HCAR2

1.49e-05378223579073
Pubmed

Short-chain fatty acids directly exert anti-inflammatory responses in podocytes and tubular epithelial cells exposed to high glucose.

HCAR3 HCAR2

1.49e-05378237215085
Pubmed

Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8.

HCAR3 HCAR2

1.49e-05378220033346
Pubmed

Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs.

PUM2 PUM1

1.49e-05378230333515
Pubmed

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.

PUM2 PUM1

1.49e-05378233397688
Pubmed

NORAD: Defender of the Genome.

PUM2 PUM1

1.49e-05378227157388
Pubmed

Gender-Dependent Phenotype in Polycystic Kidney Disease Is Determined by Differential Intracellular Ca2+ Signals.

PKD2 ANO1

1.49e-05378234199520
Pubmed

Niacin stimulates adiponectin secretion through the GPR109A receptor.

HCAR3 HCAR2

1.49e-05378219141678
Pubmed

International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B).

HCAR3 HCAR2

1.49e-05378221454438
Pubmed

TMEM14C is required for erythroid mitochondrial heme metabolism.

TMEM14B TMEM14DP

1.49e-05378225157825
Pubmed

Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.

HCAR3 HCAR2

1.49e-05378220664170
Pubmed

A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.

PUM2 PUM1

1.49e-05378225340845
Pubmed

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.

HCAR3 HCAR2

1.49e-05378224226773
Pubmed

PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells.

PUM2 PUM1

1.49e-05378228232582
Pubmed

Activation of microglial GPR109A alleviates thermal hyperalgesia in female lupus mice by suppressing IL-18 and glutamatergic synaptic activity.

HCAR3 HCAR2

1.49e-05378234919284
Pubmed

Induction of the cystine/glutamate exchanger SLC7A11 in retinal pigment epithelial cells by the antipsoriatic drug monomethylfumarate.

HCAR3 HCAR2

1.49e-05378223404113
Pubmed

Niacin receptor GPR109A inhibits insulin secretion and is down-regulated in type 2 diabetic islet beta-cells.

HCAR3 HCAR2

1.49e-05378227570060
Pubmed

Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.

PUM2 PUM1

1.49e-05378226724866
Pubmed

The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages.

HCAR3 HCAR2

1.49e-05378224845831
Pubmed

Oral Dimethyl Fumarate Targets HCA2-Expressing Skin Cells in the Imiquimod Mouse Model.

HCAR3 HCAR2

1.49e-05378235189149
Pubmed

The Butyrate-Producing Bacterium Clostridium butyricum Suppresses Clostridioides difficile Infection via Neutrophil- and Antimicrobial Cytokine-Dependent but GPR43/109a-Independent Mechanisms.

HCAR3 HCAR2

1.49e-05378233597149
Pubmed

Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells.

HCAR3 HCAR2

1.49e-05378217008386
Pubmed

Effects of high fat diet on GPR109A and GPR81 gene expression.

HCAR3 HCAR2

1.49e-05378222842580
Pubmed

Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression.

HCAR3 HCAR2

1.49e-05378222914621
Pubmed

Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide.

HCAR3 HCAR2

1.49e-05378231710686
Pubmed

COP9 signalosome component CSN-5 stabilizes PUF proteins FBF-1 and FBF-2 in Caenorhabditis elegans germline stem and progenitor cells.

PUM2 PUM1

1.49e-05378238427913
Cytoband1q44

OR2M4 OR2W3 OR2M2 OR2T7 OR2T1

1.32e-061107851q44
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2M4 OR2W3 OR2M2 OR2T7 OR2T1

2.79e-06128785chr1q44
GeneFamilyOlfactory receptors, family 2

OR2M4 OR2W3 OR2M2 OR2T7 OR2T1

1.21e-05113485149
GeneFamilyHydroxy-carboxylic acid receptors

HCAR3 HCAR2

2.07e-053482200
GeneFamilyATPase phospholipid transporting

ATP9B ATP8B1

7.09e-04154821210
GeneFamilyZinc fingers MYND-type

SMYD1 ZMYND12

1.40e-032148287
GeneFamilyIntraflagellar transport proteins|Tetratricopeptide repeat domain containing

TTC21A TTC21B

1.84e-0324482615
GeneFamilyTransient receptor potential cation channels

TRPC6 PKD2

2.50e-0328482249
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

GPM6B HIGD1B TRPC6 TMEM266 ATP8B1 CRMP1 CIDEA

4.02e-0819077710125091ad648163777b02e9f0d5e8d7f17d44a5
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231|Adult / Lineage, Cell type, age group and donor

GPM6B ATP13A4 PRTG CPAMD8 ZNF608 ACOXL

5.06e-07170776269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Adult / Lineage, Cell type, age group and donor

GPM6B ATP13A4 PRTG CPAMD8 ZNF608 ACOXL

8.29e-07185776673f0c688ae6984bc8027df2da335787924f4137
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ATP13A4 CPAMD8 NDRG1 ZNF608 MCU ACOXL

8.56e-071867762ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell15-Distal-Mesenchymal-Pericyte|Distal / Age, Tissue, Lineage and Cell class

GPM6B HIGD1B TRPC6 TMEM266 CRMP1 CIDEA

9.11e-071887764963382e54aac06bf5047c7d725393db70667ee7
ToppCellfacs-Heart-LV-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIGD1B PKD2 ANO1 CCDC80 ATP8B1 ACKR4

9.99e-07191776b7a57691a4742070cee640e285c1f4d0da95baf1
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GPM6B DPYSL3 PGAP1 TRPC6 PKD2 ANO1

9.99e-071917766688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell11.5-Distal-Mesenchymal-Pericyte|Distal / Age, Tissue, Lineage and Cell class

GPM6B HIGD1B TRPC6 TMEM266 CRMP1 CIDEA

1.09e-0619477608701590496cf85ff790e54a81493c61177e76ff
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ARHGEF28 HTR3A TRPC6 CACNG5 CIDEA

8.85e-061617753b5d7a3dab479c6959a428f3954dedd989900276
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ARHGEF28 HTR3A TRPC6 CACNG5 CIDEA

1.09e-05168775f3879a8e11eaf866f37c52e67021be43f0b8784a
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DPYSL3 CPT1C SLC5A6 CCDC80 LRP2BP

1.40e-0517777530f82b04e48940bfcaf2c22677efe6d57ae3f1a7
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ATP13A4 CPAMD8 NDRG1 ZNF608 ACOXL

1.48e-05179775815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP13A4 PRTG CPAMD8 ZNF608 ACOXL

1.69e-05184775102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

GPM6B ATP13A4 CPAMD8 ZNF608 ACOXL

1.73e-0518577598b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PRTG CPAMD8 NDRG1 ZNF608 ATP8B1

1.73e-05185775d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 MCU PKD2 XKR4 FAM83B

1.82e-0518777587b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 MCU PKD2 XKR4 FAM83B

1.82e-0518777542a1267bfc27b4460b8409ada580a87c4385841c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 MCU PKD2 XKR4 FAM83B

1.82e-0518777564afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

GPM6B DPYSL3 PGAP1 TRPC6 ANO1

1.82e-0518777592d468dde81125d51daf7abd4703741abe1ab91c
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIGD1B TRPC6 ANO1 CCDC80 CACNG5

1.97e-051907751803b1e7c36285f9eaabc3c6e9a9752c5908db3d
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIGD1B TRPC6 ANO1 CCDC80 CIDEA

2.02e-051917758597a8af294f24496c317d995f07eb5dcc25c13c
ToppCellASK454-Mesenchymal|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

GPM6B DPYSL3 HIGD1B TRPC6 CCDC80

2.02e-05191775e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCellASK454-Mesenchymal-Fibroblast|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

GPM6B DPYSL3 HIGD1B TRPC6 CCDC80

2.02e-051917751726add3f392a061536b7aff72ba84303f4a0b1f
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B PKD2 CCDC80 ATP8B1 ACKR4

2.07e-05192775671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

GPM6B HIGD1B TRPC6 ATP8B1 CIDEA

2.07e-0519277555f95454399fd533df75db06584eaa48d6ee3830
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DPYSL3 PGAP1 TRPC6 PKD2 ANO1

2.07e-0519277599ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B PKD2 CCDC80 ATP8B1 ACKR4

2.07e-05192775840a34c1b82d218be999ab5e1bcafd6370d7a4b1
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

GPM6B HIGD1B TRPC6 ATP8B1 CIDEA

2.07e-051927755000440dc1ed17e7474d340921bdff945646f27e
ToppCellwk_08-11-Epithelial-Proximal_epithelial-basal_intermediate_|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

HCAR3 ATP13A4 HCAR2 NDRG1 GCGR

2.12e-0519377583d2dd823808a2b5ca1a6889eefb541ec042b24c
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GPM6B ATP13A4 CPAMD8 ZNF608 ACOXL

2.28e-05196775ed76eeb37400ca154feae9b7ebaddb6c434f8b81
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Pericyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

GPM6B HIGD1B TRPC6 CRMP1 CIDEA

2.34e-0519777544cd1ece3633a31e8c9b667cd3cbc2749c06f478
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B DPYSL3 NDRG1 PKD2 CCDC80

2.34e-05197775cfd4cc5fb8d7a60dd5c0d2a1a7bad7ba38c19d40
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Pericyte|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

GPM6B HIGD1B TRPC6 CRMP1 CIDEA

2.40e-0519877572aad5b2dcd8b0bde58828fa4f8129fe6cb6a21d
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Pericyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

GPM6B HIGD1B TRPC6 CRMP1 CIDEA

2.40e-0519877576d46950c11cb4708866db0da54ce00d5c0adab8
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

GPM6B HIGD1B TRPC6 ANO1 CIDEA

2.40e-05198775c9c96066c7fa897b583657f0b77ea093920ae9ba
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

GPM6B HIGD1B TRPC6 ANO1 CIDEA

2.46e-05199775aacd3ffa40a6e6f435aa9be5b959d88812eb69d4
ToppCellTracheal|World / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGEF28 ENPP3 ZG16B ANO1 ATP8B1

2.52e-05200775682960e28542a3d6c119047cd0131941932cfdea
ToppCell10x_3'_v2v3-Neoplastic|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GPM6B DPYSL3 GAPDH CCDC80 CRMP1

2.52e-05200775e9c7d7cb5fa63fc92aa91d02ae8bd05438d465bc
ToppCell356C-Epithelial_cells-Epithelial-B_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

LARP1B TSSK4 CRMP1 FAM83B

9.91e-05139774aefcfda2b2db302ce4b3d2a09f767be0b1c3ac6c
ToppCell356C-Epithelial_cells-Epithelial-B_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

LARP1B TSSK4 CRMP1 FAM83B

9.91e-05139774b9c2dfab119ac0efdf931bb2910e82bccdb4e48d
ToppCellLPS-antiTNF-Endothelial-Epi-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC6A8 SLC5A6 GCGR ZMYND12

1.14e-0414477475b16adfbe84f69376e6566d531ba7919d5c5192
ToppCell368C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|368C / Donor, Lineage, Cell class and subclass (all cells)

DPYSL3 HIGD1B ZG16B CCDC80

1.40e-041527743a1414ba6a4972698c3262a00b124428835c35cb
ToppCell368C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|368C / Donor, Lineage, Cell class and subclass (all cells)

DPYSL3 HIGD1B ZG16B CCDC80

1.40e-04152774ee7855d76a49d07a032677a4dc83aa6116d50518
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HTR3A ZNF608 CACNG5 CIDEA

1.51e-04155774105d59d8a1bb8cb37eef2c1767d737b2108ac7c5
ToppCellCOVID-19-Mast_cells-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

ENPP3 TMEM266 ST8SIA1 RAB3C

1.55e-04156774bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCellCOVID-19-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

ENPP3 TMEM266 ST8SIA1 RAB3C

1.55e-04156774159504d43421ee83b9ab484816333ae549c9c2fd
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Lymphocytic-T_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HCAR2 TRPC6 ST8SIA1 CRMP1

1.55e-041567740bd32876413f3308f838f266e8c39ea0937ce5b9
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Club|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

HCAR2 ENPP3 ZG16B FAM83B

1.79e-04162774fe546c2272a70bb5f08e6e097b9accdb891eda23
ToppCellBronchial_Biopsy-Immune-Neutrophils|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

CUL2 HCAR3 PGAP1 ZMYND12

1.79e-04162774985adca17b0c99563feef7910f3da5df31e636b6
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Adult / Lineage, Cell type, age group and donor

GPM6B ATP13A4 CPAMD8 ACOXL

1.83e-04163774e819a1d6d28290854aa0672b3a18fa9e293d8f23
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Npy_(Cortical_subplate_interneuron)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SMYD1 ZMYND12 FAM83B

1.86e-046477328acc0d394b8cd2fd93ae5e0801f0ff1dd4b16ac
ToppCellClub-club-7|World / Class top

TTC21B TMOD4 FAM83B

1.86e-0464773df413c5328966480479c41826461c4d817fbe33d
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Npy_(Cortical_subplate_interneuron)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SMYD1 ZMYND12 FAM83B

1.86e-046477361414e0fa2242f156f0f45f8733b831b7f965dd8
ToppCellwk_15-18-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor_intermediate_|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ATP13A4 NDRG1 ZNF608 FAM83B

1.92e-04165774f6887c64af0f26e33316bc5587487e24d76ece2a
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

GPM6B ATP13A4 ZNF608 ACOXL

1.96e-04166774c20479fe7a4306320d7f26e78bf956225f00f35a
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SMYD1 ANO1 CCDC80 XKR4

2.01e-04167774c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SMYD1 ANO1 TMEM266 XKR4

2.01e-04167774743df5908c1ceb43b34b240d9f9649f30f4142fa
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SMYD1 ANO1 CCDC80 XKR4

2.01e-04167774351f8de1fbdf742ac74f9099b254d515ab539bb2
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell-mesothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SMYD1 ANO1 TMEM266 XKR4

2.01e-041677741adb566f98af0109c8cc6e36033b89651e2c75e7
ToppCellControl|World / group, cell type (main and fine annotations)

ATP13A4 ARHGEF28 ACOXL LRP2BP

2.05e-04168774a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPC6 TMEM266 XKR4 ITGAV

2.05e-04168774e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMYD1 ANO1 CCDC80 RAB3C

2.10e-0416977487116c33c5ca8cb1862e103e5607b1df4d264569
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP13A4 CPAMD8 ZNF608 ACOXL

2.15e-04170774a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

HTR3A TRPC6 CACNG5 CIDEA

2.20e-04171774f9ae7964a3740f559431125c17c660549798cccc
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HIGD1B TRPC6 ATP8B1 CIDEA

2.20e-04171774285533ca2a6a411773313166bee35542f34d1a3c
ToppCell(0)_Normal/No_Treatment-(3)_LEPR+_perivascular_cells|World / Stress and Cell class

GPM6B HCAR2 DPYSL3 CCDC80

2.45e-04176774ce2c32b5ce0da848eb4da35ce4d215cdf74d9113
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122|Adult / Lineage, Cell type, age group and donor

GPM6B ATP13A4 CPAMD8 ACOXL

2.45e-041767743fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-5|TCGA-Lung / Sample_Type by Project: Shred V9

SLC6A8 HCAR3 NDRG1 FAM83B

2.50e-04177774a0c7d08469c513cecf87777c19876884f1511570
ToppCelldroplet-Heart-nan-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIGD1B TRPC6 ANO1 GCGR

2.50e-04177774dbdbdc8ed9ef0b529694242ef9f9f07a42e16005
ToppCellTracheal-10x3prime_v2-Stromal-Pericyte-Muscle_pericyte_systemic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

HIGD1B TRPC6 CRMP1

2.53e-04717735d63a582229520b2a037f3c27f772e34cdee092b
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP13A4 CPAMD8 ZNF608 ACOXL

2.56e-04178774f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCellPND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP13A4 ARHGEF28 ANO1 GCGR

2.56e-04178774a3af5d9c55858e36be0498081029ecb0acaeb3d3
ToppCellPND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP13A4 ARHGEF28 ANO1 GCGR

2.56e-04178774b3b88989bd602cfb55bb5c47731deb99288a8952
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIGD1B TRPC6 ANO1 CACNG5

2.61e-041797748da6863edc756540bb097cc7221c1408640d9bb4
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A8 TMEM266 GCGR PGAP6

2.61e-04179774d0fa700648db8ce76a8aa689879a25048299fa40
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIGD1B TRPC6 ANO1 CACNG5

2.61e-04179774f39c13c99a07d009cc677e363ffe089089c64916
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A8 TMEM266 GCGR PGAP6

2.61e-041797742e49b215b71438400aebb483f2c2c08d5e956961
ToppCellfacs-Heart-RV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIGD1B TRPC6 ANO1 CACNG5

2.67e-041807740059e5acade6c895fd629767bea1c15f40b0d1b0
ToppCellfacs-Heart-RV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIGD1B TRPC6 ANO1 CACNG5

2.67e-04180774dfb8412e1e06fa7349e66eea2ef27d9ea98b7893
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

ATP13A4 CPAMD8 MCU ACOXL

2.73e-04181774c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PRTG ARHGEF28 ZNF608 ANO1

2.78e-04182774724c33ad2fb525cbcfa5efa3362675eb42a5636d
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPYSL3 GCGR RAB3C CRMP1

2.78e-04182774be32b5b8153c1053cbb55f1fccfa27c3ee97c1e1
ToppCelltumor_Lung-Fibroblasts-Pericytes|tumor_Lung / Location, Cell class and cell subclass

HIGD1B TRPC6 ANO1 CIDEA

2.84e-04183774a03dd563af9b15cb1f5de5732a229405a9f82d84
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRPC6 TMEM266 ATP8B1 XKR4

2.84e-041837743c516fe5083f02bad1f464ed284010b4131a833c
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP13A4 PRTG ACOXL LRP2BP

2.84e-041837746847c1252d6bb105524f812658112517fd351eab
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRPC6 TMEM266 ATP8B1 XKR4

2.84e-041837749c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCelldroplet-Limb_Muscle-nan-21m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HTR3A HIGD1B ANO1 TMOD4

2.84e-041837746f5dbac2748f50105f0f548d189c42ef14287019
ToppCellCOVID-19-B_cells-Plasma_cells|COVID-19 / group, cell type (main and fine annotations)

SPCS2 LRRK1 LARP1B ACOXL

2.84e-04183774130c109f63a5e3c8f83cb96e32f4addf513b6415
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 ATP13A4 CPAMD8 CRMP1

2.84e-04183774cfae90c309622b5d499e62a3a8a8b9746478d28d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DPYSL3 TRPC6 TMEM266 XKR4

2.84e-041837747c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-3|TCGA-Lung / Sample_Type by Project: Shred V9

SLC6A8 PGAP1 EDDM13 FAM83B

2.90e-04184774ea4ccebe2d54279fcc517e4f0bfa652b91a808bb
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Proximal_secretory_progenitors|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

HCAR2 DPYSL3 NDRG1 ATP8B1

2.90e-04184774fcb5dd4fb3fa79f3b6029fad32a474cacde35a3b
ToppCellfacs-Skin-nan-18m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HCAR2 MCU ANO1 TMOD4

2.90e-04184774dc7f6ee4062856a02423fff8b1cce62d46a9355c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRPC6 TMEM266 ATP8B1 XKR4

2.90e-041847747294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HIGD1B TRPC6 ANO1 GCGR

2.90e-04184774327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B2_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPYSL3 ARHGEF28 HTR3A CRMP1

2.96e-041857743d6711030ca4328357b06d5497cf98cdefcd7f4f
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TRPC6 ANO1 ATP8B1 CRMP1

2.96e-04185774a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPYSL3 HTR3A MLNR CRMP1

2.96e-0418577494d0f283d63d932f310cc5a17ea893d71ba60f5e
ToppCellControl-Epithelial-Club|World / Disease state, Lineage and Cell class

ATP13A4 CPAMD8 ZNF608 ACOXL

3.02e-041867749798428691408e17ff2af2fe2d1b345f074d67e4
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B TMEM266 TSSK4 RAB3C

3.02e-04186774a1ab273b01971d6a892912560d387685dd657179
Drugcurarine

HCAR3 HCAR2 HTR3A KPNB1

1.54e-0626754CID000198004
Diseasedonor genotype effect measurement, chronic graft versus host disease

ARHGEF28 STT3B

1.72e-048742EFO_0007892, MONDO_0020547
Diseasenephronophthisis (implicated_via_orthology)

TTC21A TTC21B

2.21e-049742DOID:12712 (implicated_via_orthology)
Diseasesleep duration

SMYD1 TRPC6 PUM1 LMBRD1 RAB3C FAM83B

3.00e-04362746EFO_0005271
Diseasethyroxine measurement, triiodothyronine measurement

EPHB2 CCDC80

8.24e-0417742EFO_0005130, EFO_0008392
Diseasecholelithiasis

ANO1 ATP8B1 VPS13B

1.43e-0388743EFO_0004799

Protein segments in the cluster

PeptideGeneStartEntry
YMGYIMEKEQAYTDA

TTC21B

1236

Q7Z4L5
FCMFKYMALYSMIQY

ATP13A4

901

Q4VNC1
VNSFMVYMAYKDLYQ

DPYSL3

161

Q14195
FSMESSNYYAEMKFY

HTR3A

221

P46098
TKIDYLMNYMVYTIF

ATP8B1

331

O43520
AEKMYIGNAMYGNYA

ACOXL

126

Q9NUZ1
LRKEYGMTYNDFFMV

CCDC80

701

Q76M96
TTAYYRGAMGFILMY

RAB3C

96

Q96E17
ALYTMMKDQYANYVV

PUM2

991

Q8TB72
ILYVFMGASFKNYVM

ACKR4

301

Q9NPB9
YGQMMIYAKFDKNVY

ARHGEF28

11

Q8N1W1
VVFLYYGTTMGMYFR

OR1A2

246

Q9Y585
FYGTVMVMYVSPTYG

OR11H4

261

Q8NGC9
TVVSLFYGAAMYTYM

OR2T1

296

O43869
YMRQGYGKMLIDFSY

KAT7

481

O95251
IMLGAVYTMYSDYVK

HIGD1B

76

Q9P298
VTYFITYGSAMAMYA

MCU

266

Q8NE86
FLMMYAQSKGIYYVQ

MGAT4B

251

Q9UQ53
GFNTMEKIKYFQMYF

NLRP8

356

Q86W28
YDEKVDMFSYGMVLY

LRRK1

1441

Q38SD2
SFTYMNSMLDPVVYY

HCAR2

281

Q8TDS4
YMIYSLAPQYVMYGS

LMBRD1

426

Q9NUN5
YQGFLMVGYATIYTM

ATP9B

961

O43861
CQKVMYGSYSYMWSF

FAM83B

236

Q5T0W9
YGRYSGKMYFQTMTE

EPHB2

516

P29323
MVVGMYYGAALFMYI

OR2M2

246

Q96R28
SVVGLYYGAAMFMYM

OR2M4

246

Q96R27
MVVVSLFYGAAMYTY

OR2T7

236

P0C7T2
TVVSLFYGNIIYMYM

OR2W3

246

Q7Z3T1
LAEAFKYFVQGMGYM

NDRG1

301

Q92597
KMYSSFQVMYTVGYS

GCGR

136

P47871
QGNLVEYYYKMKFFT

LRP2BP

246

Q9P2M1
VYLYMYSKNGTMHGF

ANO1

816

Q5XXA6
IAIYTSMMTSDNYYY

PGAP6

706

Q9HCN3
IYMMATTYNYAVLKF

GPM6B

241

Q13491
ALYTMMKDQYANYVV

PUM1

1111

Q14671
ASNYTFYIVAYMPMG

PRTG

486

Q2VWP7
NSNYYMMDFLYVTPT

CPT1C

251

Q8TCG5
MYTLLSGLYKYMFQK

ARFRP1

1

Q13795
SVYLFMKRYTAEDMY

CACNG5

196

Q9UF02
QFWYKYTYMEEMLGN

CRNKL1

311

Q9BZJ0
DQTYCNKMEYMTDYF

ENPP3

376

O14638
SVYNYMGTCAEVYMK

CPAMD8

826

Q8IZJ3
GMVYIYDGKNMSSLY

ITGAV

281

P06756
MNYLGKPYVAMVTTY

CUL2

566

Q13617
YMVMTYLFVSYNKGD

EDDM13

126

A0A1B0GTR0
LVKIMSLYYQYMETY

KPNB1

241

Q14974
SLYYQYMETYMGPAL

KPNB1

246

Q14974
VYMAYKDVYQMSDSQ

CRMP1

166

Q14194
FMVQLLTGVYYAMYN

FAM126B

236

Q8IXS8
PFQTELNTSMMYYYD

LARP1B

186

Q659C4
LNTSMMYYYDDGTGV

LARP1B

191

Q659C4
YINTEDSRMMYFSQY

MLNR

321

O43193
DHMENVYGYLMKYTN

OSBPL11

56

Q9BXB4
IGLVMFAYYQEYPMS

SLC5A6

311

Q9Y289
NYMVYMFQYDSTHGK

GAPDH

41

P04406
SFTYMNSMLDPVVYY

HCAR3

281

P49019
SFYARRMVDGYMKLY

SMYD1

371

Q8NB12
FVDNMKIYNHSYIYM

ST8SIA1

206

Q92185
KIYNHSYIYMPAFSM

ST8SIA1

211

Q92185
KCSMSYMFEYPEYQK

PGAP1

36

Q75T13
ASMVIVFYCNTYYIM

SLC6A8

136

P48029
NVKATMYEMYSVSYD

CIDEA

146

O60543
RGMVMYTSKDRYFYF

ZG16B

131

Q96DA0
YGSVYEAFYTKQKVM

TSSK4

36

Q6SA08
YFVMMGILTIYTSYK

SPCS2

121

Q15005
TLLNCLMYKMSYYRF

STT3B

711

Q8TCJ2
SVTFVGIMGMRSYYY

TMEM14DP

71

A8MWL7
FYWKMVYEYADVSML

XKR4

291

Q5GH76
SVTFVGVMGMRSYYY

TMEM14B

71

Q9NUH8
NKSCYKAYEYMGFIM

TTC21A

1231

Q8NDW8
ILTYGMMSSNVYYYT

PKD2

236

Q13563
VYYYTRMMSQLFLDT

PKD2

246

Q13563
DMYTLMSNKQYYDAL

TMOD4

136

Q9NZQ9
GMEYKGYLVSVDGYM

SNRPF

26

P62306
AYSKMDSKSYGMYED

ZC3H4

181

Q9UPT8
FYYLMMNSSKAQEYG

ZMYND12

316

Q9H0C1
GQYAYGLYMDQKSLM

ZNF608

1081

Q9ULD9
FYMDYLYTMENTSGK

VPS13B

536

Q7Z7G8
YYSIQGKFMSIYDVS

SLC9C2

546

Q5TAH2
VAFMIGMFNLYSYYI

TRPC6

646

Q9Y210
YFQQSAVAMYMLYEK

ZBED1

321

O96006
ATMKDDMNSYISQYY

TMEM266

321

Q2M3C6