Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	1.97e-07	5	55	3	GO:0030156
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C RIMBP3B DYNC1H1	9.01e-07	28	56	4	GO:0002177
GeneOntologyCellularComponent	basement membrane	FREM2 FRAS1 THBS4 ITGB4	3.21e-04	122	56	4	GO:0005604
HumanPheno	Calvarial skull defect	UBR1 FREM2 FRAS1 ITGB4	3.33e-06	28	20	4	HP:0001362
HumanPheno	Onycholysis of fingernails	HOXC13 ITGB4	1.46e-05	2	20	2	HP:0040039
HumanPheno	Malformed lacrimal duct	FREM2 FRAS1	4.38e-05	3	20	2	HP:0007993
HumanPheno	Midline nasal groove	FREM2 FRAS1	8.75e-05	4	20	2	HP:0004112
HumanPheno	Bifid tongue	FREM2 NEK1 FRAS1	1.13e-04	25	20	3	HP:0010297
HumanPheno	Aplasia of the bladder	FREM2 ITGB4	1.45e-04	5	20	2	HP:0010477
HumanPheno	Midline defect of the nose	FREM2 NEK1 FRAS1	1.96e-04	30	20	3	HP:0004122
HumanPheno	Cryptophthalmos	FREM2 FRAS1	2.18e-04	6	20	2	HP:0001126
HumanPheno	Cleft ala nasi	FREM2 FRAS1	2.18e-04	6	20	2	HP:0003191
HumanPheno	Slender finger	PIEZO2 FBN2 PEPD MAPK1 MAPK8IP3	2.95e-04	159	20	5	HP:0001238
HumanPheno	Female pseudohermaphroditism	FREM2 FRAS1	3.04e-04	7	20	2	HP:0010458
HumanPheno	Wide pubic symphysis	FREM2 FRAS1	3.04e-04	7	20	2	HP:0003183
MousePheno	cryptophthalmos	FREM2 FRAS1	3.46e-05	3	48	2	MP:0005242
MousePheno	ectopic manchette	RIMBP3 RIMBP3C RIMBP3B	3.54e-05	19	48	3	MP:0009377
MousePheno	detached sperm flagellum	RIMBP3 RIMBP3C RIMBP3B	4.84e-05	21	48	3	MP:0008893
MousePheno	fetal bleb	FREM2 FRAS1	6.90e-05	4	48	2	MP:0008856
MousePheno	abnormal interdigital cell death	FRAS1 FBN2	1.15e-04	5	48	2	MP:0009874
Domain	Calx_beta	FREM2 FRAS1 ITGB4	1.41e-06	8	56	3	SM00237
Domain	Calx_beta	FREM2 FRAS1 ITGB4	2.12e-06	9	56	3	IPR003644
Domain	Calx-beta	FREM2 FRAS1 ITGB4	2.12e-06	9	56	3	PF03160
Domain	FN3	RIMBP3 RIMBP3C CMYA5 RIMBP3B ITGB4	3.21e-04	199	56	5	PS50853
Domain	FN3_dom	RIMBP3 RIMBP3C CMYA5 RIMBP3B ITGB4	4.02e-04	209	56	5	IPR003961
Domain	SH3	RIMBP3 SRGAP3 RIMBP3C SRGAP2 RIMBP3B	4.67e-04	216	56	5	SM00326
Domain	SH3	RIMBP3 SRGAP3 RIMBP3C SRGAP2 RIMBP3B	4.67e-04	216	56	5	PS50002
Domain	EGF_CA	FAT2 THBS4 STAB2 FBN2	4.90e-04	122	56	4	SM00179
Domain	SH3_domain	RIMBP3 SRGAP3 RIMBP3C SRGAP2 RIMBP3B	5.08e-04	220	56	5	IPR001452
Domain	EGF-like_Ca-bd_dom	FAT2 THBS4 STAB2 FBN2	5.21e-04	124	56	4	IPR001881
Domain	EGF	FRAS1 FAT2 THBS4 STAB2 FBN2	6.85e-04	235	56	5	SM00181
Domain	EGF-like_dom	FRAS1 FAT2 THBS4 STAB2 FBN2	8.88e-04	249	56	5	IPR000742
Domain	EGF_1	FAT2 THBS4 STAB2 FBN2 ITGB4	9.88e-04	255	56	5	PS00022
Domain	EGF-like_CS	FAT2 THBS4 STAB2 FBN2 ITGB4	1.10e-03	261	56	5	IPR013032
Domain	EGF_2	FAT2 THBS4 STAB2 FBN2 ITGB4	1.17e-03	265	56	5	PS01186
Domain	Growth_fac_rcpt_	FRAS1 THBS4 STAB2 FBN2	1.23e-03	156	56	4	IPR009030
Domain	SH3_9	RIMBP3 RIMBP3C RIMBP3B	1.66e-03	78	56	3	PF14604
Domain	FCH	SRGAP3 SRGAP2	1.96e-03	22	56	2	PF00611
Domain	FCH	SRGAP3 SRGAP2	1.96e-03	22	56	2	SM00055
Domain	FCH_dom	SRGAP3 SRGAP2	2.15e-03	23	56	2	IPR001060
Domain	SH3_2	RIMBP3 RIMBP3C RIMBP3B	2.19e-03	86	56	3	IPR011511
Domain	SH3_2	RIMBP3 RIMBP3C RIMBP3B	2.19e-03	86	56	3	PF07653
Domain	FN3	RIMBP3C CMYA5 RIMBP3B ITGB4	2.29e-03	185	56	4	SM00060
Domain	F_BAR	SRGAP3 SRGAP2	2.53e-03	25	56	2	IPR031160
Domain	F_BAR	SRGAP3 SRGAP2	2.53e-03	25	56	2	PS51741
Domain	-	RIMBP3 F11R RIMBP3C CMYA5 RIMBP3B ITGB4 AMIGO1	3.52e-03	663	56	7	2.60.40.10
Domain	ConA-like_dom	FAT2 THBS4 CMYA5 ITGB4	4.19e-03	219	56	4	IPR013320
Domain	Ig-like_fold	RIMBP3 F11R RIMBP3C CMYA5 RIMBP3B ITGB4 AMIGO1	4.97e-03	706	56	7	IPR013783
Domain	EGF_3	FAT2 THBS4 STAB2 FBN2	5.38e-03	235	56	4	PS50026
Domain	EGF	FAT2 THBS4 STAB2	6.41e-03	126	56	3	PF00008
Domain	Sushi	HP SRPX	1.06e-02	52	56	2	PF00084
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	1.58e-08	4	56	3	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	3.94e-08	5	56	3	17855024
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	1.42e-06	14	56	3	17662146
Pubmed	ERK2-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP at Ser298 augments hepatic gluconeogenesis.	MAPK1 PCMT1	2.55e-06	2	56	2	24358311
Pubmed	aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation.	F11R PARD3	2.55e-06	2	56	2	22371556
Pubmed	Identification of two novel CAKUT-causing genes by massively parallel exon resequencing of candidate genes in patients with unilateral renal agenesis.	FREM2 FRAS1	2.55e-06	2	56	2	21900877
Pubmed	Molecular study of 33 families with Fraser syndrome new data and mutation review.	FREM2 FRAS1	2.55e-06	2	56	2	18671281
Pubmed	The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.	SRGAP3 SRGAP2	2.55e-06	2	56	2	23505444
Pubmed	Novel loss of function variants in FRAS1 AND FREM2 underlie renal agenesis in consanguineous families.	FREM2 FRAS1	2.55e-06	2	56	2	32643034
Pubmed	The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM).	F11R PARD3	7.63e-06	3	56	2	11447115
Pubmed	Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system.	SRGAP3 SRGAP2	7.63e-06	3	56	2	19137586
Pubmed	Expression of Fraser syndrome genes in normal and polycystic murine kidneys.	FREM2 FRAS1	7.63e-06	3	56	2	21993971
Pubmed	Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis.	MAPK1 PARD3 ITGB4	1.13e-05	27	56	3	23466739
Pubmed	Segmental and restricted localization pattern of Fras1 in the developing meningeal basement membrane in mouse.	FREM2 FRAS1	1.52e-05	4	56	2	24101214
Pubmed	The role of FREM2 and FRAS1 in the development of congenital diaphragmatic hernia.	FREM2 FRAS1	1.52e-05	4	56	2	29618029
Pubmed	Expression of the NEK family in normal and cancer tissue: an immunohistochemical study.	NEK1 NEK3	1.52e-05	4	56	2	31906878
Pubmed	Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice.	FREM2 FRAS1	1.52e-05	4	56	2	23221805
Pubmed	Role of plasma membrane localization of the scaffold protein JSAP1 during differentiation of cerebellar granule cell precursors.	MAPK1 MAPK8IP3	1.52e-05	4	56	2	21156008
Pubmed	Ligation of beta4 integrins activates PKB/Akt and ERK1/2 by distinct pathways-relevance of the keratin filament.	MAPK1 ITGB4	1.52e-05	4	56	2	20307589
Pubmed	Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.	FREM2 FRAS1	1.52e-05	4	56	2	36495293
Pubmed	Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.	MAPK1 MAPK8IP3	1.52e-05	4	56	2	15537893
Pubmed	Differential localization profile of Fras1/Frem proteins in epithelial basement membranes of newborn and adult mice.	FREM2 FRAS1	1.52e-05	4	56	2	18563433
Pubmed	Activation of ERK and NF-κB during HARE-Mediated Heparin Uptake Require Only One of the Four Endocytic Motifs.	STAB2 MAPK1	1.52e-05	4	56	2	27100626
Pubmed	Identification of a region in the human IRS2 promoter essential for stress induced transcription depending on SP1, NFI binding and ERK activation in HepG2 cells.	NFIC MAPK1	1.52e-05	4	56	2	19755487
Pubmed	Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs.	FREM2 FRAS1	1.52e-05	4	56	2	15838507
Pubmed	Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development.	FREM2 FRAS1	2.54e-05	5	56	2	17251066
Pubmed	The hyaluronan receptor for endocytosis mediates hyaluronan-dependent signal transduction via extracellular signal-regulated kinases.	STAB2 MAPK1	2.54e-05	5	56	2	18387958
Pubmed	Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3.	FREM2 FRAS1	2.54e-05	5	56	2	23536828
Pubmed	Differential expression and/or activation of P38MAPK, erk1/2, and jnk during the initiation and progression of prostate cancer.	MAPK1 MAPK8IP3	2.54e-05	5	56	2	12661038
Pubmed	Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa.	FREM2 FRAS1	2.54e-05	5	56	2	17596926
Pubmed	NIMA-related kinases: isolation and characterization of murine nek3 and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3.	NEK1 NEK3	3.80e-05	6	56	2	10393247
Pubmed	The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity.	F11R PARD3	3.80e-05	6	56	2	12953056
Pubmed	Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.	FREM2 FRAS1	3.80e-05	6	56	2	24700879
Pubmed	Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1.	FREM2 FRAS1	3.80e-05	6	56	2	17462874
Pubmed	SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance.	SRGAP3 SRGAP2	3.80e-05	6	56	2	33514561
Pubmed	FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains.	SRGAP3 SRGAP2	3.80e-05	6	56	2	12736724
Pubmed	Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.	SRGAP3 SRGAP2	3.80e-05	6	56	2	11672528
Pubmed	Mapping Extracellular Protein-Protein Interactions Using Extracellular Proximity Labeling (ePL).	FBN2 SRPX LTF SNRNP70 DYNC1H1	4.93e-05	247	56	5	39238192
Pubmed	Evidence for a role of srGAP3 in the positioning of commissural axons within the ventrolateral funiculus of the mouse spinal cord.	SRGAP3 SRGAP2	5.32e-05	7	56	2	21655271
Pubmed	Congenital Diaphragmatic Hernia Overview	FREM2 FRAS1 SMARCB1	5.71e-05	46	56	3	20301533
Pubmed	Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells.	MAPK1 ITGB4	7.09e-05	8	56	2	12105188
Pubmed	Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.	SRGAP3 RIMBP3C SRGAP2	7.34e-05	50	56	3	19807924
Pubmed	Human transcription factor protein interaction networks.	FBN2 NFIC SMARCB1 CUL9 MRPL38 SNRNP70 ZNF471 DYNC1H1 PCMT1 ZNF121	8.43e-05	1429	56	10	35140242
Pubmed	Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse.	F11R PARD3	9.10e-05	9	56	2	12515806
Pubmed	The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex.	PARD3 ITGB4	9.10e-05	9	56	2	21074722
Pubmed	Par3-mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN.	PARD3 ITGB4	9.10e-05	9	56	2	25016959
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	SRGAP3 SRGAP2 SNRNP70 DYNC1H1	1.05e-04	151	56	4	17043677
Pubmed	The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis.	FREM2 FRAS1	1.14e-04	10	56	2	15345741
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	DHX38 MRPL38 SNRNP70 IWS1	1.41e-04	163	56	4	22113938
Pubmed	The GDNF target Vsnl1 marks the ureteric tip.	FREM2 MAPK1	1.66e-04	12	56	2	21289216
Pubmed	Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.	FREM2 MAPK1 DYNC1H1	1.76e-04	67	56	3	21875946
Pubmed	Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism.	GNA15 MAPK1	1.96e-04	13	56	2	14551213
Pubmed	Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6.	LTF ALS2CL	1.96e-04	13	56	2	12140191
Pubmed	A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells.	F11R PARD3	1.96e-04	13	56	2	17057644
Pubmed	FOXD1 is required for 3D patterning of the kidney interstitial matrix.	FREM2 FBN2	1.96e-04	13	56	2	36335435
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	NELFCD DHX38 SRGAP2 LTF CMYA5 PARD3 SNRNP70 DYNC1H1 PCMT1	1.97e-04	1284	56	9	17353931
Pubmed	Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.	CUL9 PARD3	2.29e-04	14	56	2	22653443
Pubmed	PRC1 preserves epidermal tissue integrity independently of PRC2.	FREM2 ITGB4	2.29e-04	14	56	2	30567998
Pubmed	Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.	MAPK1 PARD3 ITGB4	2.46e-04	75	56	3	15951569
Pubmed	Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome.	FREM2 FRAS1	2.64e-04	15	56	2	23064016
Pubmed	Huntingtin interacting proteins are genetic modifiers of neurodegeneration.	FBN2 SRGAP3 SRGAP2 DYNC1H1	2.91e-04	197	56	4	17500595
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	ADH5 FREM2 THBS4 HP PEPD LTF DYNC1H1 PCMT1	3.00e-04	1070	56	8	23533145
Pubmed	TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart field.	MAPK1 PARD3	3.01e-04	16	56	2	25371366
Pubmed	Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development.	MAPK1 PARD3	3.01e-04	16	56	2	20823064
Pubmed	Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.	NEK1 NEK3	3.01e-04	16	56	2	8274451
Pubmed	Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.	FREM2 FRAS1	3.01e-04	16	56	2	16880404
Pubmed	Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.	DHX38 DCUN1D4 RUBCN	3.32e-04	83	56	3	9039502
Pubmed	Identification of a polymorphic, neuron-specific chromatin remodeling complex.	SRGAP3 SMARCB1	3.41e-04	17	56	2	12368262
Pubmed	The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1.	MAPK1 MAPK8IP3	3.41e-04	17	56	2	15572149
Pubmed	A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.	FREM2 FRAS1	3.83e-04	18	56	2	14730302
Pubmed	Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities.	FRAS1 SRGAP2	3.83e-04	18	56	2	20602751
Pubmed	SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.	MAPK1 PARD3	4.28e-04	19	56	2	21965329
Pubmed	Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase.	LTF MAPK1	4.28e-04	19	56	2	28424251
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	FREM2 FRAS1 FBN2 IWS1	4.35e-04	219	56	4	31353912
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	HOXC13 NELFCD NFIC SMARCB1 CUL9 MRPL38 DYNC1H1	4.37e-04	857	56	7	25609649
Pubmed	Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).	MAPK1 MAPK8IP3	4.75e-04	20	56	2	12897243
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FRAS1 SRGAP3 CUL9 RUBCN DYNC1H1	5.01e-04	407	56	5	12693553
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	ADH5 NELFCD PEPD MAPK1 TMX3 DYNC1H1 PCMT1	5.04e-04	878	56	7	37223481
Pubmed	PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα.	FREM2 ITGB4	5.24e-04	21	56	2	27856617
Pubmed	Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).	FAT2 F11R LTF ITGB4 DYNC1H1	5.59e-04	417	56	5	19199708
Pubmed	The transition from radial glial to intermediate progenitor cell is inhibited by FGF signaling during corticogenesis.	MAPK1 PARD3	5.76e-04	22	56	2	19923290
Pubmed	Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways.	MAPK1 MAPK8IP3	5.76e-04	22	56	2	15767678
Pubmed	Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli.	FREM2 FRAS1	6.30e-04	23	56	2	18787044
Pubmed	New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity.	PARD3 ITGB4	6.30e-04	23	56	2	18809908
Pubmed	ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation.	FBN2 MAPK1	6.30e-04	23	56	2	26027930
Pubmed	A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.	CUL9 DYNC1H1	6.87e-04	24	56	2	33705438
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	FREM2 FAT2 HP ITGB4	7.91e-04	257	56	4	16335952
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	NEK1 PEPD RIMBP3C MRPL38 SRGAP2 TMX3	8.28e-04	689	56	6	36543142
Pubmed	mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation.	PARD3 ITGB4	8.71e-04	27	56	2	27807348
Pubmed	Genetic link between renal birth defects and congenital heart disease.	FREM2 FRAS1	9.37e-04	28	56	2	27002738
Pubmed	Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in Ventricular Development.	MAPK1 PARD3	9.37e-04	28	56	2	37846569
Pubmed	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.	FREM2 FRAS1	1.01e-03	29	56	2	22613833
Pubmed	iRhom2 mutation leads to aberrant hair follicle differentiation in mice.	HOXC13 MAPK1	1.08e-03	30	56	2	25546423
Pubmed	Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro.	FBN2 TNFRSF19	1.08e-03	30	56	2	29555813
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	SRGAP3 SRGAP2 MAPK1 DYNC1H1	1.10e-03	281	56	4	28706196
Pubmed	Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.	FBN2 MAPK1	1.15e-03	31	56	2	25762570
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	NELFCD NFIC DHX38 SMARCB1 MAPK1 PCMT1 IWS1	1.17e-03	1014	56	7	32416067
Pubmed	Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha.	HP LTF	1.22e-03	32	56	2	9611252
Pubmed	Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice.	LTF PARD3	1.22e-03	32	56	2	26184908
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	SRGAP3 DHX38 PEPD SMARCB1 PCMT1	1.24e-03	498	56	5	36634849
Cytoband	22q11.21	RIMBP3 RIMBP3C MAPK1 RIMBP3B	1.08e-05	111	56	4	22q11.21
Cytoband	Ensembl 112 genes in cytogenetic band chr22q11	RIMBP3 SMARCB1 RIMBP3C MAPK1 RIMBP3B	1.61e-04	419	56	5	chr22q11
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	SRGAP3 SRGAP2	7.98e-04	23	33	2	1288
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	SRGAP3 SRGAP2	3.75e-03	50	33	2	721
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	HP SRPX	4.84e-03	57	33	2	1179
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM2 FRAS1 PIEZO2 STAB2 FBN2 PKD1L2	1.18e-07	184	56	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM2 FRAS1 PIEZO2 STAB2 FBN2 PKD1L2	1.18e-07	184	56	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM2 FRAS1 PIEZO2 STAB2 FBN2 PKD1L2	1.18e-07	184	56	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 FAT2 F11R SRGAP3 CMYA5	2.37e-06	170	56	5	928e42c51a7079c506f21c669c4e4c1a0df84d77
ToppCell	ILEUM-non-inflamed-(7)_Lymphatics\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	THBS4 PIEZO2 STAB2 SRPX CMYA5	3.05e-06	179	56	5	99777a8931356d1206b8ab22aaa1b1d5a600b809
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FRAS1 PIEZO2 SRGAP3 TNFRSF19 CMYA5	3.98e-06	189	56	5	203c80030df08ae112f9ae4043709f455d87ce89
ToppCell	(6)_Endothelial_cells-(6)_Endothelial-F_(Lymphatics)\|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	THBS4 PIEZO2 STAB2 HP SRGAP3	4.52e-06	194	56	5	9441202d6fa2ffbef9277d48ae9bc98876c26ec5
ToppCell	Basal_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	FRAS1 FAT2 SRGAP3 CMYA5 ITGB4	4.75e-06	196	56	5	3b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCell	Basal_cells\|World / lung cells shred on cell class, cell subclass, sample id	FRAS1 FAT2 SRGAP3 CMYA5 ITGB4	4.87e-06	197	56	5	24360b660000bdfb999d58fbf4e29585a97e1785
ToppCell	Tracheal\|World / Cell types per location group and 10X technology with lineage, and cell group designations	SRGAP3 TNFRSF19 LTF CMYA5 ITGB4	5.25e-06	200	56	5	682960e28542a3d6c119047cd0131941932cfdea
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FAT2 PIEZO2 HOXC13 TMPRSS11A	2.52e-05	135	56	4	4451c44f3ad788437f4e2ae81049fbbab53f967e
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FAT2 PIEZO2 HOXC13 TMPRSS11A	2.52e-05	135	56	4	45f67f33c8320d9fb6dbceae603b564f6a8ffd1e
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_vein-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	STAB2 SRPX LTF AMIGO1	3.81e-05	150	56	4	4f31867cb85253ff6d22f3b02ef972a42cb41123
ToppCell	Adult-Epithelial-basal_cell-D122\|Adult / Lineage, Cell type, age group and donor	FRAS1 FAT2 SRGAP3 CMYA5	4.22e-05	154	56	4	38d346402417960044ae999e61f0092b46f2b591
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 FBN2 CUL9 TMPRSS11A	4.78e-05	159	56	4	7619d0d49738dd08daf01b42664691a5323aa793
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 FBN2 CUL9 TMPRSS11A	4.78e-05	159	56	4	4000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FRAS1 FBN2 CUL9 TMPRSS11A	5.65e-05	166	56	4	5e3b998d740b24f790fad37350d704ca0ea10b77
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FRAS1 FBN2 CUL9 TMPRSS11A	5.65e-05	166	56	4	bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	THBS4 PIEZO2 SRGAP3 ITGB4	5.92e-05	168	56	4	dae37b316ce80dfe4236c4ed7f0d4e7c340fa7b6
ToppCell	Bronchial_Biopsy-Immune-T_and_NK\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	FSIP2 PIEZO2 SRPX ZNF471	5.92e-05	168	56	4	435b2f238fbb3f50427e8cdecf2220615015153c
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)\|368C / Donor, Lineage, Cell class and subclass (all cells)	THBS4 PIEZO2 SRGAP3 ITGB4	5.92e-05	168	56	4	a74c8a9e3299183fba31ce3053ef325b5dbcd104
ToppCell	Control-Epithelial_cells-Airway_basal\|Control / group, cell type (main and fine annotations)	FRAS1 FAT2 SRGAP3 ITGB4	6.34e-05	171	56	4	3965ced4be6db14265a90673502fceee425837ca
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	FAT2 F11R PARD3 TMPRSS11A	6.94e-05	175	56	4	0cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L6_LAMP5_C1QL2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RIMBP3 FBN2 RIMBP3C RIMBP3B	7.41e-05	178	56	4	39889db130216655a34796e7030ffeb372465500
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRAS1 KLHL1 TNFRSF19 SRPX	7.57e-05	179	56	4	820289f14ecf165758529c236bb220bb1a744f02
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRAS1 KLHL1 TNFRSF19 SRPX	7.57e-05	179	56	4	e5f781d35449628a7f356d71e26231dd63482eec
ToppCell	Epithelial-basal_cell\|World / Lineage, Cell type, age group and donor	FRAS1 FAT2 SRGAP3 ITGB4	7.57e-05	179	56	4	d9be6647ec7b22747dc00dce4ea307b6af412dfa
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_IL7R\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FREM2 FRAS1 KLHL1 TNFRSF19	7.90e-05	181	56	4	3e3c903b522dced6bec5dc447cc3f8bf9a9749e3
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	THBS4 STAB2 SRGAP3 ITGB4	7.90e-05	181	56	4	b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FREM2 FRAS1 KLHL1 TNFRSF19	7.90e-05	181	56	4	13270b6ba6a9c8e5681c6f40000c643ce1d9344a
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)\|367C / Donor, Lineage, Cell class and subclass (all cells)	THBS4 STAB2 SRGAP3 ITGB4	7.90e-05	181	56	4	dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THBS4 PIEZO2 SRPX CMYA5	8.07e-05	182	56	4	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	Adult-Epithelial-basal_cell\|Adult / Lineage, Cell type, age group and donor	FRAS1 FAT2 SRGAP3 ITGB4	8.25e-05	183	56	4	00a6b19ca49e3b8e0d1cd387a3515b0ff4b81c81
ToppCell	(6)_Endothelial-F_(Lymphatics)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	THBS4 PIEZO2 STAB2 SRGAP3	8.42e-05	184	56	4	03ea613e00b45c81b752c14505a0538d698f551e
ToppCell	ILEUM-inflamed-(7)_Lymphatics\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	THBS4 PIEZO2 STAB2 CMYA5	8.60e-05	185	56	4	d711dd2e91cfee723dae1ccb2b910b8cf3becc3b
ToppCell	facs-Trachea-nan-3m-Epithelial-basal_epithelial_cell_of_tracheobronchial_tree\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT2 LTF ALS2CL ITGB4	8.96e-05	187	56	4	fe9fc21192ede2eea61f419d20ccda254569d0a6
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIEZO2 F11R HP ITGB4	9.73e-05	191	56	4	b94e66ac71e73f46b0323d424e7b8b906751d584
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	THBS4 PIEZO2 STAB2 SRGAP3	9.92e-05	192	56	4	5f4f44f15d3a2846981e68296643a4634930a211
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	THBS4 PIEZO2 STAB2 SRGAP3	9.92e-05	192	56	4	5e709c0714e8eba27e03a6def0544256bedb3ced
ToppCell	IPF-Epithelial-Basal\|World / Disease state, Lineage and Cell class	FAT2 SRGAP3 PARD3 ITGB4	9.92e-05	192	56	4	9b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FAT2 CMYA5 ALS2CL ITGB4	1.01e-04	193	56	4	a5695ce2e24a62026ae28f3dea07ca4a435206b8
ToppCell	(4)_Endothelial_cells-(4)_Lymph_vessel\|(4)_Endothelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	THBS4 PIEZO2 STAB2 SRGAP3	1.03e-04	194	56	4	9735b86d3b2480a0b34d8aab8e7bd609d83c2454
ToppCell	droplet-Mammary_Gland-nan-18m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIEZO2 F11R HP LTF	1.05e-04	195	56	4	c771ac1db8bd5f3a80bd3484094a58c28983f97b
ToppCell	343B-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PIEZO2 STAB2 HP SRGAP3	1.05e-04	195	56	4	fc75f04eb475c8139cc5c35e6be22e73fb2be9e6
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 FAT2 SRGAP3 ITGB4	1.05e-04	195	56	4	6c9c58322c1df891bb4bab56dacb542c8777bb7d
ToppCell	343B-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PIEZO2 STAB2 HP SRGAP3	1.05e-04	195	56	4	83d45ff5e5bc704448431149fffb2e4c1278f279
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_basal-Basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 FAT2 SRGAP3 ITGB4	1.07e-04	196	56	4	c5adab88140a465698abcbedc6505a43cae7bfd1
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT2 FBN2 CMYA5 ITGB4	1.07e-04	196	56	4	a58bdf9de05d13d84211e09a933679d485bf8ab4
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PIEZO2 STAB2 SRGAP3 PEPD	1.07e-04	196	56	4	b04ca69b0ed44e09c989b575f747e1e819cd8008
ToppCell	Endothelial_cells-Endothelial-B\|Endothelial_cells / lung cells shred on cell class, cell subclass, sample id	THBS4 PIEZO2 STAB2 SRGAP3	1.07e-04	196	56	4	36f95f9ef74eb951e41ef46fd136ceaef45208fc
ToppCell	droplet-Mammary_Gland-nan-18m-Epithelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIEZO2 F11R HP LTF	1.07e-04	196	56	4	00f9171da4c791619e8c4c8c3c7da578c96a30ed
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PIEZO2 STAB2 SRGAP3 PEPD	1.07e-04	196	56	4	a31e227de2dc077b81881295b012d22fedbd65ed
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 FAT2 SRGAP3 ITGB4	1.10e-04	197	56	4	1e915957ea6a4550ecb9d6ee4b232aa5800faf20
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 FAT2 SRGAP3 ITGB4	1.10e-04	197	56	4	de772bd2b4cda843777ac879b1087e6444199dfb
ToppCell	390C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PIEZO2 STAB2 HP SRGAP3	1.10e-04	197	56	4	c84e988c2ad06087aafda9e3b68e9e72fd0e75f1
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FRAS1 PIEZO2 SRGAP3 TNFRSF19	1.10e-04	197	56	4	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	390C-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PIEZO2 STAB2 HP SRGAP3	1.10e-04	197	56	4	6195f945b3fd6da07907619267d49e96d1044f8f
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 FAT2 SRGAP3 ITGB4	1.10e-04	197	56	4	107cb153ea7fc74bbd244dbb9d0499c0a8506724
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT2 SRGAP3 PARD3 ITGB4	1.12e-04	198	56	4	9718f4c013c347f1b3c785ae232dd2fb6c1fe298
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	UBR1 THBS4 PARD3 ITGB4	1.14e-04	199	56	4	a13f4b8a039304e685464cc8879659824cad5a3e
ToppCell	proximal-Epithelial-Proximal_Basal-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAT2 SRGAP3 CMYA5 ITGB4	1.16e-04	200	56	4	de9aec87c86ad0a1bd5e0737c2aae0ec6f269bca
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NEK3 PIEZO2 FBN2 PARD3	1.16e-04	200	56	4	347a510755374c6a66acee326565dfc447993f18
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuroepithelial-Proteoglycan-expressing_cell\|10w / Sample Type, Dataset, Time_group, and Cell type.	FRAS1 PIEZO2 SRPX ITGB4	1.16e-04	200	56	4	07d2133c85e0a4eb8bef653ee15ecd0f1b2bbd44
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FAT2 F11R SRGAP3 ITGB4	1.16e-04	200	56	4	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	proximal-3-Epithelial-Proximal_Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAT2 SRGAP3 CMYA5 ITGB4	1.16e-04	200	56	4	3a0c84f9a551fc2581ec3693481eada297d83f7b
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SRGAP3 TNFRSF19 LTF ITGB4	1.16e-04	200	56	4	030efc36bbb848da31b0db3f74d46aac9c79cc9b
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuroepithelial\|10w / Sample Type, Dataset, Time_group, and Cell type.	FRAS1 PIEZO2 SRPX ITGB4	1.16e-04	200	56	4	ff0b2675c68e9fc1fa16b3276431f199f3642eac
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FAT2 F11R GNA15 ITGB4	1.16e-04	200	56	4	2a9d715aba8bdef2341b0d44ff60825c074a4b03
ToppCell	proximal-Epithelial-Proximal_Basal\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAT2 SRGAP3 CMYA5 ITGB4	1.16e-04	200	56	4	ff2afa5c0352c214525129f9ff85afc139fe44d2
Disease	Cryptophthalmos syndrome	FREM2 FRAS1	8.78e-06	3	51	2	C0265233
Disease	FRASER SYNDROME 1	FREM2 FRAS1	8.78e-06	3	51	2	C4551480
Disease	Fraser syndrome (implicated_via_orthology)	FREM2 FRAS1	1.75e-05	4	51	2	DOID:0090001 (implicated_via_orthology)
Disease	thrombospondin-3 measurement	THBS4 CMYA5	1.75e-05	4	51	2	EFO_0803151
Disease	Unilateral agenesis of kidney	FREM2 FRAS1	8.15e-05	8	51	2	C0266294
Disease	blood lead measurement	SRGAP3 PEPD SRGAP2	2.06e-04	66	51	3	EFO_0007040
Disease	stem Cell Growth Factor beta measurement	PIEZO2 STAB2 ZNF121	3.01e-04	75	51	3	EFO_0008292
Disease	Yu-Zhi constitution type	FREM2 PIEZO2	3.03e-04	15	51	2	EFO_0007638
Disease	teratocarcinoma-derived growth factor 1 measurement	LTF ALS2CL	3.46e-04	16	51	2	EFO_0008297
Disease	Astrocytosis	MAPK1 ITGB4	3.92e-04	17	51	2	C3887640
Disease	Gliosis	MAPK1 ITGB4	3.92e-04	17	51	2	C0017639
Disease	haptoglobin measurement	HP DHX38	6.02e-04	21	51	2	EFO_0004640
Disease	apolipoprotein L1 measurement	HP DHX38	8.57e-04	25	51	2	EFO_0021854
Disease	Alzheimer's disease (is_marker_for)	MAPK1 SNRNP70 DYNC1H1 PCMT1	1.02e-03	257	51	4	DOID:10652 (is_marker_for)
Disease	Polydactyly	FREM2 NEK1 FRAS1	1.10e-03	117	51	3	C0152427
Disease	Ischemic stroke, factor VII measurement	ADH5 PARD3	1.15e-03	29	51	2	EFO_0004619, HP_0002140
Disease	pulmonary hypertension (is_implicated_in)	HP MAPK1	1.24e-03	30	51	2	DOID:6432 (is_implicated_in)
Disease	cholesteryl ester 22:6 measurement	SRGAP3 SRGAP2	1.41e-03	32	51	2	EFO_0010350
Disease	cysteine-rich with EGF-like domain protein 1 measurement	SRGAP3 SRGAP2	1.41e-03	32	51	2	EFO_0021870

Protein segments in the cluster

Peptide	Gene	Start	Entry
GSMCGYGICEYSTDE	ALS2CL	416	Q60I27
YEYAGTDDVVGPEGM	DCUN1D4	111	Q92564
VQVEDGGVYTCYAMG	AMIGO1	331	Q86WK6
EMTDGGVDYSFECIG	ADH5	256	P11766
DMGGEYYCFASDITC	PEPD	276	P12955
AGDYIYIFGDMDEDG	RIMBP3B	861	A6NNM3
AGDYIYIFGDMDEDG	RIMBP3C	861	A6NJZ7
MDSEYYSGDQSDDGG	IWS1	1	Q96ST2
IGEGAYGMVCSAYDN	MAPK1	31	P28482
GVVTSFCGDYGMIDE	CT55	41	Q8WUE5
NGYCVYEETGEFMSS	FRAS1	346	Q86XX4
AGMSKYQEDTCYGDA	HP	341	P00738
MDEGGGVVVYQDDYC	MAPK8IP3	6	Q9UPT6
EENGSLYIVMDYCEG	NEK1	71	Q96PY6
PGAIMDEDYYGSAAE	NELFCD	6	Q8IXH7
SYYDMSELLADCGGT	FREM2	2641	Q5SZK8
NEMESEGGGIETYRY	FSIP2	1696	Q5CZC0
YEGSDMVESDYGSCE	FAT2	4331	Q9NYQ8
YTRMYTGCVDGPEGS	GNA15	316	P30679
EDDDCTYSYTMEGDG	ITGB4	676	P16144
AEGHLYIVMEYCDGG	NEK3	71	P51956
CSTRDGDGDEEEYYG	MARCHF9	46	Q86YJ5
PYSLDAEDMADYGEG	PKD1L2	2056	Q7Z442
YMVLSGDEASESGCY	CMYA5	676	Q8N3K9
MYVYEDSAAESGIGG	HOXC13	16	P31276
LYSYESSGGMHEECV	ELSPBP1	16	Q96BH3
CQEMYLTYGDGEEVG	DYNC1H1	2186	Q14204
DDGGYYDGMSVEAQS	CUL9	2211	Q8IWT3
EGSYECSCSEGYALM	FBN2	1261	P35556
EYEGGRYLCSGEGMF	RUBCN	451	Q92622
GTYMHCGDDEDCFTG	SPACA4	36	Q8TDM5
DDYGFEDYGTDCDNM	PPP4R1L	16	Q9P1A2
GCDDELMYGGVSSYE	PARD3	1091	Q8TEW0
TYTCMVSEEGGNSYG	F11R	106	Q9Y624
RDMYMESEGGDGYLA	SNRNP70	411	P08621
GDGRMGYAEEAPYDA	PCMT1	141	P22061
GEADAMSLDGGYVYT	LTF	406	P02788
AGDYIYIFGDMDEDG	RIMBP3	861	Q9UFD9
CLVATGGADAYYEMG	IMPA1	201	P29218
DDGEFYMIGSEVGNY	SMARCB1	21	Q12824
GYMKCSSDGDNYGAT	SRPX	271	P78539
SMEEDVDTSPGGDYY	NFIC	286	P08651
IMCYGIYTADTDGGY	TMX3	391	Q96JJ7
GDGYICGKDVDIDSY	THBS4	456	P35443
AYAVGEDDLMPVYCG	MRPL38	176	Q96DV4
EGPVYEKCMAGGEEY	SRGAP3	701	O43295
EGPVYSRGGSMEDYC	SRGAP2	686	O75044
EYEATGYDVGAMGAE	PIEZO2	1791	Q9H5I5
MDPDLAYGTYTGSCG	UBR1	1146	Q8IWV7
AGYEGDGTLCSEMDP	STAB2	856	Q8WWQ8
EDGYTDYGMIGCTQP	DHX38	571	Q92620
FMYDDACMEGITSYG	ZNF471	101	Q9BX82
GDTYDCDEYGENFPM	ZNF121	36	P58317
MELSKECGFGYGEDA	TNFRSF19	56	Q9NS68
YMEGIYDACRGDSGG	TMPRSS11A	356	Q6ZMR5
GGRDGSSCLSSMEYY	KLHL1	606	Q9NR64