Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmonoatomic ion channel activity

ANO2 CACNA2D1 TTYH2 ANO1 ABCC9 GRIA3 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ANO7 SEC61A1

4.61e-0845916418GO:0005216
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA2D1 ANO1 ABCC9 GRIA3 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A SEC61A1

1.61e-0734316415GO:0005261
GeneOntologyMolecularFunctionATP-dependent activity

UBA5 DNHD1 ATP7B DNAH10 ABCA13 SMCHD1 ABCC9 CCT2 CHD7 MORC4 DNAH14 FBH1 G3BP1 KCNJ8 EIF4A1 ERCC6L2 MACF1 ABCC12 ATP1A4 TOP2A

1.64e-0761416420GO:0140657
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA2D1 ATP7B ABCC9 GRIA3 LETM1 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ATP1A4 SEC61A1

3.01e-0746516417GO:0046873
GeneOntologyMolecularFunctionchannel activity

ANO2 CACNA2D1 TTYH2 ANO1 ABCC9 GRIA3 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ANO7 SEC61A1

3.39e-0752516418GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

ANO2 CACNA2D1 TTYH2 ANO1 ABCC9 GRIA3 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ANO7 SEC61A1

3.49e-0752616418GO:0022803
GeneOntologyMolecularFunctionribosome binding

SRP72 LETM1 NOMO1 NMD3 SEC61A2 G3BP1 NOMO2 SEC61A1 NOMO3

6.55e-071201649GO:0043022
GeneOntologyMolecularFunctiongated channel activity

ANO2 CACNA2D1 TTYH2 ANO1 ABCC9 GRIA3 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A ANO7

7.06e-0733416414GO:0022836
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

ANO2 CACNA2D1 ATP7B TTYH2 ANO1 ABCC9 GRIA3 LETM1 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ANO7 ATP1A4 SEC61A1

1.12e-0675816421GO:0015318
GeneOntologyMolecularFunctiontransmembrane transporter activity

ANO2 CACNA2D1 ATP7B ABCA13 SLC2A7 TTYH2 SLC19A3 ANO1 ABCC9 GRIA3 LETM1 RYR1 RYR2 RYR3 SEC61A2 SLC22A18 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ANO7 ABCC12 ATP1A4 SEC61A1

1.22e-06118016427GO:0022857
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN2A SCN4A SCN8A SCN9A

2.01e-06261645GO:0005248
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR1 RYR2 RYR3

2.16e-0641643GO:0005219
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

ANO2 CACNA2D1 ATP7B TTYH2 ANO1 ABCC9 GRIA3 LETM1 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ANO7 ATP1A4 SEC61A1

2.28e-0679316421GO:0015075
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN2A SCN8A SCN9A

4.12e-06141644GO:0031402
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

ANO2 TTYH2 ANO1 ABCC9 GRIA3 RYR1 RYR2 RYR3 KCNJ8 ANO7

4.56e-0619316410GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

ANO2 TTYH2 ANO1 ABCC9 GRIA3 RYR1 RYR2 RYR3 KCNJ8 ANO7

5.47e-0619716410GO:0022834
GeneOntologyMolecularFunctiontransporter activity

ANO2 CACNA2D1 ATP7B ABCA13 SLC2A7 TTYH2 SLC19A3 ANO1 ABCC9 GRIA3 LETM1 RYR1 RYR2 RYR3 SEC61A2 SLC22A18 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ANO7 ABCC12 ATP1A4 SEC61A1

6.37e-06128916427GO:0005215
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA2D1 ATP7B ANO1 ABCC9 GRIA3 LETM1 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ATP1A4 SEC61A1

9.30e-0666416418GO:0008324
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

KCNC2 SCN1A KCNJ8 SCN2A

9.60e-06171644GO:0099508
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR1 RYR2 RYR3

1.07e-0561643GO:0048763
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA2D1 ATP7B ABCC9 GRIA3 LETM1 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ATP1A4 SEC61A1

1.67e-0562716417GO:0022890
GeneOntologyMolecularFunctionATP hydrolysis activity

ATP7B DNAH10 ABCA13 SMCHD1 ABCC9 CCT2 CHD7 MORC4 FBH1 G3BP1 EIF4A1 MACF1 ABCC12 ATP1A4

1.74e-0544116414GO:0016887
GeneOntologyMolecularFunctionintracellularly calcium-gated channel activity

ANO2 TTYH2 ANO1 ANO7

1.92e-05201644GO:0141147
GeneOntologyMolecularFunctionintracellularly calcium-gated chloride channel activity

ANO2 TTYH2 ANO1 ANO7

1.92e-05201644GO:0005229
GeneOntologyMolecularFunctionribonucleoprotein complex binding

SRP72 LETM1 NOMO1 NMD3 SEC61A2 G3BP1 NOMO2 SEC61A1 NOMO3

5.30e-052061649GO:0043021
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN2A SCN8A SCN9A

5.70e-05261644GO:0031420
GeneOntologyMolecularFunctionsodium channel activity

SCN1A SCN2A SCN4A SCN8A SCN9A

6.69e-05521645GO:0005272
GeneOntologyMolecularFunctionN-acetyl-L-aspartate-L-glutamate ligase activity

RIMKLA RIMKLB

6.70e-0521642GO:0072590
GeneOntologyMolecularFunctionligand-gated calcium channel activity

GRIA3 RYR1 RYR2 RYR3

1.16e-04311644GO:0099604
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA2D1 ANO1 ABCC9 RYR1 KCNC2 SCN1A KCNJ8 SCN2A

1.33e-041821648GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA2D1 ANO1 ABCC9 RYR1 KCNC2 SCN1A KCNJ8 SCN2A

1.43e-041841648GO:0022832
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

ANO1 ABCC9 GRIA3 RYR1 RYR2 RYR3 KCNJ8

1.60e-041401647GO:0099094
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA2D1 GRIA3 LETM1 RYR1 RYR2 RYR3 SEC61A1

2.54e-041511647GO:0015085
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ATP7B ABCA13 ABCC9 KCNJ8 ABCC12 ATP1A4

2.82e-041091646GO:0042626
GeneOntologyMolecularFunctionelectron-transferring-flavoprotein dehydrogenase activity

TXNDC12 AIFM2

3.98e-0441642GO:0004174
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR1 RYR2 RYR3

4.05e-04181643GO:0015278
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNHD1 DNAH10 DNAH14

4.05e-04181643GO:0008569
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

HBS1L ATP7B DNAH10 ABCA13 SMCHD1 ABCC9 CCT2 CHD7 MORC4 FBH1 G3BP1 EIF4A1 MACF1 ABCC12 DNM1 ATP1A4

6.65e-0477516416GO:0017111
GeneOntologyMolecularFunctioncalcium channel activity

CACNA2D1 GRIA3 RYR1 RYR2 RYR3 SEC61A1

6.93e-041291646GO:0005262
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

ANO2 TTYH2 ANO1 ANO7

7.53e-04501644GO:0099095
GeneOntologyMolecularFunctionphospholipid scramblase activity

ANO2 ANO1 ANO7

8.54e-04231643GO:0017128
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor

TXNDC12 AIFM2

9.84e-0461642GO:0016649
GeneOntologyMolecularFunctionATP-activated inward rectifier potassium channel activity

ABCC9 KCNJ8

9.84e-0461642GO:0015272
GeneOntologyMolecularFunctionpyridoxal phosphate binding

PDXDC1 GAD1 GOT1L1 GCAT

1.16e-03561644GO:0030170
GeneOntologyMolecularFunctionvitamin B6 binding

PDXDC1 GAD1 GOT1L1 GCAT

1.23e-03571644GO:0070279
GeneOntologyMolecularFunctionchloride channel inhibitor activity

STX8 VAMP8

1.37e-0371642GO:0019869
GeneOntologyMolecularFunctioncell adhesion molecule binding

DAB2IP PDXDC1 FERMT1 OBSCN ACTN3 ITGA2B TENM2 CEMIP2 FASN TJP1 MACF1 TLN2 TAGLN2

1.37e-0359916413GO:0050839
GeneOntologyMolecularFunctionpyrophosphatase activity

HBS1L ATP7B DNAH10 ABCA13 SMCHD1 ABCC9 CCT2 CHD7 MORC4 FBH1 G3BP1 EIF4A1 MACF1 ABCC12 DNM1 ATP1A4

1.52e-0383916416GO:0016462
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNHD1 DNAH10 DNAH14

1.53e-03281643GO:0051959
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

HBS1L ATP7B DNAH10 ABCA13 SMCHD1 ABCC9 CCT2 CHD7 MORC4 FBH1 G3BP1 EIF4A1 MACF1 ABCC12 DNM1 ATP1A4

1.54e-0384016416GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

HBS1L ATP7B DNAH10 ABCA13 SMCHD1 ABCC9 CCT2 CHD7 MORC4 FBH1 G3BP1 EIF4A1 MACF1 ABCC12 DNM1 ATP1A4

1.54e-0384016416GO:0016818
GeneOntologyMolecularFunctionATPase-coupled monoatomic cation transmembrane transporter activity

ATP7B ABCC9 KCNJ8 ATP1A4

1.69e-03621644GO:0019829
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-NH group of donors

ALDH1L1 TXNDC12 AIFM2

1.88e-03301643GO:0016645
GeneOntologyMolecularFunctionvitamin binding

PDXDC1 GAD1 GOT1L1 FASN CYP2R1 GCAT

2.17e-031611646GO:0019842
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

RYR1 RYR2 RYR3

2.48e-03331643GO:0005217
GeneOntologyMolecularFunctionactin filament binding

SYNE1 SPTA1 FERMT1 ACTN3 MACF1 TLN2 TAGLN2

2.76e-032271647GO:0051015
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SCN1A SCN2A SCN4A SCN8A SCN9A ATP1A4

2.92e-031711646GO:0015081
GeneOntologyMolecularFunctioncalmodulin binding

OBSCN ADCY3 RYR1 RYR2 RYR3 TJP1 SCN2A

2.97e-032301647GO:0005516
GeneOntologyMolecularFunctionligase activity

UBA5 RIMKLA MARS1 GART PARS2 RIMKLB

3.19e-031741646GO:0016874
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNHD1 DNAH10 DNAH14

3.44e-03371643GO:0045505
GeneOntologyMolecularFunctionprimary active transmembrane transporter activity

ATP7B ABCA13 ABCC9 KCNJ8 ABCC12 ATP1A4

3.56e-031781646GO:0015399
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

CHD7 FBH1 G3BP1 ERCC6L2 TOP2A

4.00e-031271645GO:0008094
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

CACNA2D1 RYR2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A

3.16e-08621648GO:0086002
GeneOntologyBiologicalProcesscardiac muscle cell contraction

CACNA2D1 ABCC9 RYR2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A

5.54e-08931649GO:0086003
GeneOntologyBiologicalProcessstriated muscle contraction

CACNA2D1 ABCC9 ACTN3 RYR1 RYR2 RYR3 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A

1.75e-0721716412GO:0006941
GeneOntologyBiologicalProcessmembrane depolarization during action potential

CACNA2D1 SCN1A SCN2A SCN4A SCN8A SCN9A

3.69e-07361646GO:0086010
GeneOntologyBiologicalProcesscardiac muscle cell action potential

CACNA2D1 RYR2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A

4.62e-07871648GO:0086001
GeneOntologyBiologicalProcessactin-mediated cell contraction

CACNA2D1 ABCC9 RYR2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A

8.11e-071271649GO:0070252
GeneOntologyBiologicalProcessactin filament-based movement

CACNA2D1 ABCC9 RYR2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A

3.82e-061531649GO:0030048
GeneOntologyBiologicalProcessaction potential

CACNA2D1 ABCC9 RYR2 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A

4.93e-0620116410GO:0001508
GeneOntologyBiologicalProcesscardiac muscle contraction

CACNA2D1 ABCC9 RYR2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A

7.80e-061671649GO:0060048
GeneOntologyBiologicalProcessmulti-pass transmembrane protein insertion into ER membrane

NOMO1 NOMO2 NOMO3

4.00e-0591643GO:0160063
GeneOntologyBiologicalProcessadult walking behavior

HTRA2 CHD7 SCN1A SCN8A AGTPBP1

4.74e-05501645GO:0007628
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

ANO2 CACNA2D1 ATP7B TTYH2 ANO1 ABCC9 CHD7 LETM1 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ANO7 ATP1A4 SEC61A1

5.89e-05101716421GO:0098660
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

ANO2 CACNA2D1 ATP7B TTYH2 ANO1 ABCC9 GRIA3 CHD7 LETM1 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ANO7 ATP1A4 SEC61A1

7.58e-05111516422GO:0034220
GeneOntologyBiologicalProcesscellular response to caffeine

RYR1 RYR2 RYR3

7.77e-05111643GO:0071313
GeneOntologyBiologicalProcessestablishment of protein localization to endoplasmic reticulum

SRP72 RYR2 SEC61A2 MACF1 SEC61A1

8.23e-05561645GO:0072599
GeneOntologyBiologicalProcessmuscle contraction

CACNA2D1 ABCC9 ACTN3 RYR1 RYR2 RYR3 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A

8.89e-0540016412GO:0006936
GeneOntologyBiologicalProcessprotein insertion into ER membrane

NOMO1 NOMO2 SEC61A1 NOMO3

1.03e-04311644GO:0045048
GeneOntologyBiologicalProcesschemosensory behavior

CHD7 ADCY3 SCN9A CFAP69

1.03e-04311644GO:0007635
GeneOntologyBiologicalProcesswalking behavior

HTRA2 CHD7 SCN1A SCN8A AGTPBP1

1.15e-04601645GO:0090659
GeneOntologyBiologicalProcessregulation of presynaptic membrane potential

GRIA3 KCNC2 SCN1A KCNJ8

1.16e-04321644GO:0099505
GeneOntologyBiologicalProcessmuscle system process

CACNA2D1 ABCC9 ACTN3 RYR1 RYR2 RYR3 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A AKAP13 FBXO32

1.25e-0454716414GO:0003012
GeneOntologyBiologicalProcessneuronal action potential

SCN1A SCN2A SCN4A SCN8A SCN9A

1.45e-04631645GO:0019228
GeneOntologyBiologicalProcessregulation of membrane potential

CACNA2D1 SYNE1 ANO1 ABCC9 GRIA3 RYR2 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ATP1A4

1.57e-0455916414GO:0042391
GeneOntologyBiologicalProcessprotein localization to organelle

RAPSN HTRA2 SYNE1 FERMT1 OBSCN ZDHHC5 SRP72 CCT2 TXNDC12 RYR2 NOMO1 NMD3 TYK2 KAT7 SEC61A2 NOMO2 MACF1 AKAP11 SEC61A1 TNPO3 NOMO3

1.58e-04109116421GO:0033365
GeneOntologyBiologicalProcesscellular response to purine-containing compound

RYR1 RYR2 RYR3

1.68e-04141643GO:0071415
GeneOntologyBiologicalProcessheart process

CACNA2D1 ABCC9 RYR2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A AKAP13

1.89e-0430916410GO:0003015
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum

CHD7 RYR1 RYR2 RYR3

2.07e-04371644GO:0014808
GeneOntologyBiologicalProcessolfactory behavior

CHD7 ADCY3 CFAP69

2.09e-04151643GO:0042048
GeneOntologyBiologicalProcessmonoatomic ion transport

ANO2 CACNA2D1 ATP7B TTYH2 ANO1 ABCC9 GRIA3 CHD7 LETM1 RYR1 RYR2 RYR3 SLC22A18 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ANO7 HSD3B2 ATP1A4 SEC61A1

2.26e-04137416424GO:0006811
GeneOntologyBiologicalProcessnerve development

CHD7 SALL1 KCNC2 SCN1A SCN2A SCN8A

2.38e-041091646GO:0021675
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by endoplasmic reticulum

CHD7 RYR1 RYR2 RYR3

2.55e-04391644GO:1903514
GeneOntologyBiologicalProcesstransmission of nerve impulse

SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A

2.75e-041121646GO:0019226
GeneOntologyBiologicalProcessresponse to ATP

ABCC9 RYR1 RYR3 KCNJ8

2.82e-04401644GO:0033198
GeneOntologyBiologicalProcesscilium movement involved in cell motility

DNHD1 ARMC3 DNAH10 CATSPERD ADCY3 DNAH14 ATP1A4 CFAP69

2.84e-042101648GO:0060294
GeneOntologyBiologicalProcesscilium-dependent cell motility

DNHD1 ARMC3 DNAH10 CATSPERD ADCY3 DNAH14 ATP1A4 CFAP69

3.33e-042151648GO:0060285
GeneOntologyBiologicalProcesscilium or flagellum-dependent cell motility

DNHD1 ARMC3 DNAH10 CATSPERD ADCY3 DNAH14 ATP1A4 CFAP69

3.33e-042151648GO:0001539
GeneOntologyBiologicalProcessamino acid metabolic process

GAD1 ACADSB RIMKLA MARS1 GART PARS2 GOT1L1 RIMKLB GCAT SMS

3.36e-0433216410GO:0006520
GeneOntologyBiologicalProcessactin filament-based process

CACNA2D1 SPTA1 OBSCN ABCC9 ACTN3 RYR2 CSF1R TJP1 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A TLN2 AKAP13 AKAP11 TAGLN2

3.55e-0491216418GO:0030029
GeneOntologyBiologicalProcessfemale meiosis chromosome separation

SYCP3 TOP2A

3.73e-0441642GO:0051309
GeneOntologyBiologicalProcesssarcoplasmic reticulum calcium ion transport

CHD7 RYR1 RYR2 RYR3

4.08e-04441644GO:0070296
GeneOntologyBiologicalProcessmembrane depolarization

CACNA2D1 SCN1A SCN2A SCN4A SCN8A SCN9A

4.17e-041211646GO:0051899
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

CACNA2D1 ATP7B ANO1 ABCC9 CHD7 LETM1 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ATP1A4 SEC61A1

5.20e-0494216418GO:0098655
GeneOntologyBiologicalProcesspost-translational protein targeting to endoplasmic reticulum membrane

SEC61A2 MACF1 SEC61A1

5.91e-04211643GO:0006620
GeneOntologyBiologicalProcesscellular response to ATP

ABCC9 RYR1 RYR3

5.91e-04211643GO:0071318
GeneOntologyBiologicalProcessresponse to caffeine

RYR1 RYR2 RYR3

5.91e-04211643GO:0031000
GeneOntologyBiologicalProcessheart contraction

CACNA2D1 ABCC9 RYR2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A

6.53e-042981649GO:0060047
GeneOntologyBiologicalProcessprotein insertion into membrane

NOMO1 NOMO2 SEC61A1 NOMO3

6.67e-04501644GO:0051205
GeneOntologyBiologicalProcessproteinogenic amino acid metabolic process

GAD1 RIMKLA GART GOT1L1 RIMKLB GCAT SMS

7.10e-041851647GO:0170039
GeneOntologyCellularComponentmonoatomic ion channel complex

ANO2 CACNA2D1 CATSPERD TTYH2 ANO1 ABCC9 GRIA3 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A

8.64e-0937816517GO:0034702
GeneOntologyCellularComponentcation channel complex

CACNA2D1 CATSPERD ABCC9 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A

4.83e-0823516513GO:0034703
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN2A SCN4A SCN8A SCN9A

1.65e-07171655GO:0001518
GeneOntologyCellularComponenttransmembrane transporter complex

ANO2 CACNA2D1 CATSPERD TTYH2 ANO1 ABCC9 GRIA3 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ATP1A4

1.81e-0752316518GO:1902495
GeneOntologyCellularComponenttransporter complex

ANO2 CACNA2D1 CATSPERD TTYH2 ANO1 ABCC9 GRIA3 RYR1 RYR2 RYR3 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ATP1A4

3.79e-0755016518GO:1990351
GeneOntologyCellularComponentsarcolemma

CACNA2D1 OBSCN ABCC9 RYR1 RYR2 RYR3 SCN1A KCNJ8 SCN2A FLOT1

2.80e-0619016510GO:0042383
GeneOntologyCellularComponentsodium channel complex

SCN1A SCN2A SCN4A SCN8A SCN9A

2.94e-06291655GO:0034706
GeneOntologyCellularComponentmyofibril

SYNE1 OBSCN ABCC9 ACTN3 RYR1 RYR2 RYR3 SCN1A KCNJ8 SCN8A FBXO32

1.15e-0527316511GO:0030016
GeneOntologyCellularComponentpresynaptic membrane

ANO2 CACNA2D1 ANO1 GRIA3 KCNC2 SCN1A KCNJ8 SCN2A SCN8A C1QB DNM1

1.32e-0527716511GO:0042734
GeneOntologyCellularComponentmembrane protein complex

STX8 ANO2 CACNA2D1 CATSPERD HTRA2 SYNE1 TTYH2 ANO1 ABCC9 GRIA3 ITGA2B RYR1 RYR2 RYR3 TYK2 SEC61A2 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A DNM1 ATP1A4 VAMP8 FLOT1 SEC61A1

1.68e-05149816528GO:0098796
GeneOntologyCellularComponentcontractile muscle fiber

SYNE1 OBSCN ABCC9 ACTN3 RYR1 RYR2 RYR3 SCN1A KCNJ8 SCN8A FBXO32

2.02e-0529016511GO:0043292
GeneOntologyCellularComponentZ disc

OBSCN ACTN3 RYR1 RYR2 RYR3 SCN1A SCN8A FBXO32

2.71e-051511658GO:0030018
GeneOntologyCellularComponentsarcomere

SYNE1 OBSCN ABCC9 ACTN3 RYR1 RYR2 RYR3 SCN1A SCN8A FBXO32

2.98e-0524916510GO:0030017
GeneOntologyCellularComponentmulti-pass translocon complex

NOMO1 NOMO2 NOMO3

3.92e-0591653GO:0160064
GeneOntologyCellularComponentI band

OBSCN ACTN3 RYR1 RYR2 RYR3 SCN1A SCN8A FBXO32

5.33e-051661658GO:0031674
GeneOntologyCellularComponentsynaptic membrane

ANO2 CACNA2D1 RAPSN SYNE1 ANO1 GRIA3 TENM2 PTPRA KCNC2 SCN1A KCNJ8 SCN2A SCN8A C1QB DNM1

6.21e-0558316515GO:0097060
GeneOntologyCellularComponentcell-cell contact zone

OBSCN TJP1 SCN1A SCN2A TLN2 FLOT1

1.01e-04941656GO:0044291
GeneOntologyCellularComponentpresynaptic active zone

GAD1 CACNA2D1 GRIA3 KCNJ8 SCN8A EGFLAM FLOT1

1.31e-041411657GO:0048786
GeneOntologyCellularComponentplasma membrane protein complex

CACNA2D1 CATSPERD HTRA2 ABCC9 GRIA3 ITGA2B RYR1 TYK2 KCNC2 SCN1A KCNJ8 SCN2A SCN4A SCN8A SCN9A ATP1A4 FLOT1

1.64e-0478516517GO:0098797
GeneOntologyCellularComponentER membrane insertion complex

NOMO1 NOMO2 NOMO3

1.65e-04141653GO:0072379
GeneOntologyCellularComponentpotassium ion-transporting ATPase complex

ABCC9 KCNJ8

1.85e-0431652GO:0031004
GeneOntologyCellularComponentintercalated disc

OBSCN TJP1 SCN1A SCN2A TLN2

2.01e-04681655GO:0014704
GeneOntologyCellularComponentcalcium channel complex

CACNA2D1 CATSPERD RYR1 RYR2 RYR3

2.81e-04731655GO:0034704
GeneOntologyCellularComponentinward rectifying potassium channel

ABCC9 KCNJ8

3.68e-0441652GO:0008282
GeneOntologyCellularComponentT-tubule

CACNA2D1 ABCC9 RYR1 SCN1A SCN2A

4.06e-04791655GO:0030315
GeneOntologyCellularComponentsmooth endoplasmic reticulum

RYR1 RYR2 RYR3 HSD3B2

4.72e-04461654GO:0005790
GeneOntologyCellularComponentnode of Ranvier

SCN1A SCN2A SCN8A

4.99e-04201653GO:0033268
GeneOntologyCellularComponentSec61 translocon complex

SEC61A2 SEC61A1

6.10e-0451652GO:0005784
GeneOntologyCellularComponentmain axon

KCNC2 SCN1A SCN2A SCN8A DNM1

7.01e-04891655GO:0044304
GeneOntologyCellularComponenttranslocon complex

SEC61A2 SEC61A1

9.10e-0461652GO:0071256
GeneOntologyCellularComponentsupramolecular fiber

KRT16 DNAH10 SYNE1 OBSCN ABCC9 CCT2 ACTN3 DNAH14 RYR1 RYR2 RYR3 KRT23 SCN1A KCNJ8 SCN8A MACF1 AKAP13 CEP295 FBXO32 DNM1

1.03e-03117916520GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

KRT16 DNAH10 SYNE1 OBSCN ABCC9 CCT2 ACTN3 DNAH14 RYR1 RYR2 RYR3 KRT23 SCN1A KCNJ8 SCN8A MACF1 AKAP13 CEP295 FBXO32 DNM1

1.12e-03118716520GO:0099081
GeneOntologyCellularComponentrough endoplasmic reticulum membrane

SEC61A2 PI4KB SEC61A1

1.52e-03291653GO:0030867
GeneOntologyCellularComponentaxon initial segment

SCN1A SCN2A SCN8A

1.52e-03291653GO:0043194
GeneOntologyCellularComponentjunctional membrane complex

RYR1 RYR3

2.15e-0391652GO:0030314
GeneOntologyCellularComponentinner dynein arm

DNHD1 DNAH10

2.67e-03101652GO:0036156
GeneOntologyCellularComponentjunctional sarcoplasmic reticulum membrane

RYR1 RYR2

2.67e-03101652GO:0014701
GeneOntologyCellularComponentpresynaptic active zone membrane

CACNA2D1 GRIA3 KCNJ8 SCN8A

3.39e-03781654GO:0048787
GeneOntologyCellularComponentcytoplasmic side of plasma membrane

HTRA2 SPTA1 RYR1 RYR2 RYR3 TYK2

3.55e-031851656GO:0009898
HumanPhenoRigidity

UBA5 CACNA2D1 ATP7B HTRA2 SLC19A3 PARS2 RYR1 CSF1R KCNC2 SCN1A SCN2A SCN8A SCN9A DNM1

5.74e-072146814HP:0002063
HumanPhenoImpulsivity

UBA5 CACNA2D1 HTRA2 PARS2 KCNC2 SCN1A SCN2A SCN8A SCN9A DEPDC5 DNM1

3.39e-061496811HP:0100710
HumanPhenoUnsteady gait

UBA5 CACNA2D1 RAPSN GRIA3 CHD7 PARS2 CSF1R TMTC3 KCNC2 SACS SCN1A SCN8A SMS DNM1 CAPRIN1 AGTPBP1

1.22e-053576816HP:0002317
HumanPhenoStatus epilepticus

UBA5 CACNA2D1 SLC19A3 GRIA3 PARS2 KCNC2 SCN1A SCN2A SCN8A SCN9A DEPDC5 DNM1

1.44e-052076812HP:0002133
HumanPhenoFocal hemiclonic seizure

CACNA2D1 SCN1A SCN2A SCN8A SCN9A

1.58e-0525685HP:0006813
HumanPhenoHypsarrhythmia

UBA5 GAD1 CACNA2D1 PARS2 KCNC2 SCN1A SCN2A SCN8A DEPDC5 DNM1 CAPRIN1

2.70e-051856811HP:0002521
HumanPhenoStatus epilepticus with prominent motor symptoms

KCNC2 SCN1A SCN2A SCN9A DEPDC5

3.38e-0529685HP:0032658
HumanPhenoFocal impaired awareness seizure

CACNA2D1 KCNC2 SCN1A SCN2A SCN8A SCN9A MACF1 DEPDC5 DNM1

3.74e-05126689HP:0002384
HumanPhenoEEG with generalized epileptiform discharges

UBA5 GAD1 CACNA2D1 PARS2 KCNC2 SCN1A SCN2A SCN8A SCN9A DEPDC5 DNM1 CAPRIN1 PIGO

4.42e-052706813HP:0011198
HumanPhenoDysgenesis of the hippocampus

SCN1A SCN2A SCN9A MACF1

4.69e-0516684HP:0025101
HumanPhenoComplex febrile seizure

SCN1A SCN2A SCN8A SCN9A

4.69e-0516684HP:0011172
HumanPhenoHyposmia

ATP7B HTRA2 SMCHD1 CHD7 ADCY3 SCN9A

5.69e-0552686HP:0004409
HumanPhenoEEG with multifocal slow activity

UBA5 CACNA2D1 PARS2 KCNC2 SCN8A DNM1

5.69e-0552686HP:0010844
HumanPhenoInterictal epileptiform activity

UBA5 GAD1 CACNA2D1 GRIA3 PARS2 KCNC2 SCN1A SCN2A SCN8A SCN9A DEPDC5 DNM1 CAPRIN1 PIGO

6.01e-053196814HP:0011182
HumanPhenoAtypical absence status epilepticus

SCN1A SCN2A SCN9A DNM1

6.07e-0517684HP:0011151
HumanPhenoAbnormal nervous system electrophysiology

UBA5 GAD1 CACNA2D1 RAPSN ATP7B SYNE1 OBSCN GRIA3 CHD7 DDB2 LETM1 PARS2 RYR1 CSF1R KCNC2 SACS SCN1A SCN2A SCN4A SCN8A SCN9A DEPDC5 SMS DNM1 CAPRIN1 PIGO

6.90e-059246826HP:0001311
HumanPhenoInterictal EEG abnormality

UBA5 GAD1 CACNA2D1 GRIA3 PARS2 KCNC2 SCN1A SCN2A SCN8A SCN9A DEPDC5 DNM1 CAPRIN1 PIGO

7.37e-053256814HP:0025373
HumanPhenoEpileptic spasm

UBA5 GAD1 SLC19A3 KCNC2 SCN1A SCN2A SCN8A MACF1 DEPDC5 DNM1 CAPRIN1

7.63e-052076811HP:0011097
HumanPhenoGeneralized non-convulsive status epilepticus without coma

SCN1A SCN2A SCN9A DNM1

7.72e-0518684HP:0032860
HumanPhenoGait disturbance

UBA5 CACNA2D1 RAPSN ATP7B HTRA2 MARS1 SYNE1 SMCHD1 OBSCN SLC19A3 GRIA3 CHD7 LETM1 PARS2 RYR1 RYR3 CSF1R TMTC3 CYP2R1 KCNC2 SACS SCN1A SCN2A SCN4A SCN8A SCN9A ZFYVE26 SMS DNM1 CAPRIN1 TNPO3 PIGO AGTPBP1

8.23e-0513566833HP:0001288
HumanPhenoNon-convulsive status epilepticus without coma

SCN1A SCN2A SCN9A DNM1

1.20e-0420684HP:0032671
HumanPhenoPhotosensitive myoclonic seizure

SCN1A SCN2A SCN9A

1.21e-048683HP:0001327
HumanPhenoCyanotic episode

SCN1A SCN2A SCN9A

1.21e-048683HP:0200048
HumanPhenoCentrally nucleated skeletal muscle fibers

SYNE1 OBSCN RYR1 RYR3 SCN4A TNPO3

1.29e-0460686HP:0003687
HumanPhenoFocal-onset seizure

CACNA2D1 GRIA3 CSF1R TMTC3 KCNC2 SCN1A SCN2A SCN8A SCN9A MACF1 DEPDC5 SMS DNM1 CAPRIN1

1.45e-043466814HP:0007359
HumanPhenoEEG with abnormally slow frequencies

UBA5 CACNA2D1 PARS2 KCNC2 SCN1A SCN8A DNM1

1.49e-0488687HP:0011203
HumanPhenoHyperkalemia

OBSCN RYR1 SCN4A HSD3B2 SEC61A1

1.67e-0440685HP:0002153
HumanPhenoCuboid-shaped vertebral bodies

ABCC9 KCNJ8

1.76e-042682HP:0004634
HumanPhenoFocal clonic seizure

CACNA2D1 SCN1A SCN2A SCN8A SCN9A

2.12e-0442685HP:0002266
HumanPhenoDecreased fetal movement

UBA5 CACNA2D1 RAPSN SYNE1 LETM1 PARS2 RYR1 KCNC2 SCN4A SCN8A DNM1

2.28e-042346811HP:0001558
HumanPhenoReduced tendon reflexes

UBA5 CACNA2D1 RAPSN MARS1 SYNE1 OBSCN GRIA3 DDB2 PARS2 RYR1 KCNC2 SACS SCN4A SCN8A SCN9A DNM1 CAPRIN1 PIGO AGTPBP1

3.06e-046176819HP:0001315
HumanPhenoFocal motor seizure

CACNA2D1 GRIA3 SCN1A SCN2A SCN8A SCN9A DEPDC5 SMS

3.12e-04131688HP:0011153
HumanPhenoContinuous spike and waves during slow sleep

CACNA2D1 KCNC2 SCN2A

3.48e-0411683HP:0031491
HumanPhenoLimited neck range of motion

SCN1A SCN2A SCN9A

3.48e-0411683HP:0000466
HumanPhenoPrenatal movement abnormality

UBA5 CACNA2D1 RAPSN SYNE1 LETM1 PARS2 RYR1 KCNC2 SCN4A SCN8A DNM1

3.53e-042466811HP:0001557
HumanPhenoMuscle weakness

UBA5 CACNA2D1 RAPSN ATP7B MARS1 SYNE1 SMCHD1 SPTA1 OBSCN SLC19A3 GRIA3 CHD7 PARS2 RYR1 RYR3 CYP2R1 KCNC2 SACS SCN1A SCN2A SCN4A SCN8A ZFYVE26 DNM1 CAPRIN1 TNPO3 AGTPBP1

3.66e-0410796827HP:0001324
HumanPhenoAbnormal peripheral nervous system morphology

UBA5 CACNA2D1 RAPSN ATP7B KRT16 HTRA2 MARS1 SYNE1 SMCHD1 OBSCN SLC19A3 GRIA3 CHD7 DDB2 ADCY3 LETM1 PARS2 RYR1 SALL1 CSF1R KCNC2 SACS SCN1A SCN4A SCN8A SCN9A ZFYVE26 DEPDC5 DNM1 CAPRIN1 PIGO AGTPBP1

3.82e-0413956832HP:0000759
HumanPhenoAbnormality of central nervous system electrophysiology

UBA5 GAD1 CACNA2D1 RAPSN GRIA3 CHD7 DDB2 LETM1 PARS2 CSF1R KCNC2 SACS SCN1A SCN2A SCN8A SCN9A DEPDC5 SMS DNM1 CAPRIN1 PIGO

4.03e-047386821HP:0030178
HumanPhenoStatus epilepticus without prominent motor symptoms

SCN1A SCN2A SCN9A DNM1

4.04e-0427684HP:0031475
HumanPhenoSimple febrile seizure

SCN1A SCN2A SCN8A DEPDC5

4.04e-0427684HP:0011171
HumanPhenoEpilepsia partialis continua

SCN1A SCN2A SCN9A

4.59e-0412683HP:0012847
HumanPhenoFocal automatism seizure

SCN1A SCN2A SCN8A

4.59e-0412683HP:0032898
HumanPhenoFocal aware seizure

SCN1A SCN2A SCN9A DEPDC5

4.67e-0428684HP:0002349
HumanPhenoSymblepharon

FERMT1 LAMA3

5.22e-043682HP:0430007
HumanPhenoPelvic girdle muscle weakness

RAPSN SMCHD1 RYR1 SCN4A TNPO3

5.34e-0451685HP:0003749
HumanPhenoSick sinus syndrome

CACNA2D1 ABCC9 RYR2 KCNJ8

5.37e-0429684HP:0011704
HumanPhenoGowers sign

RAPSN SYNE1 RYR1 RYR3 SCN4A CAPRIN1

5.46e-0478686HP:0003391
HumanPhenoAbnormal morphology of the pelvis musculature

RAPSN SMCHD1 RYR1 SCN4A TNPO3

5.84e-0452685HP:0001469
HumanPhenoAbnormality of the hip-girdle musculature

RAPSN SMCHD1 RYR1 SCN4A TNPO3

5.84e-0452685HP:0001445
HumanPhenoGeneralized cerebral atrophy/hypoplasia

SCN1A SCN2A SCN9A

5.91e-0413683HP:0007058
HumanPhenoProgressive gait ataxia

SACS SCN1A SCN2A SCN9A

6.13e-0430684HP:0007240
HumanPhenoProgressive ataxia

SACS SCN1A SCN2A SCN9A

6.13e-0430684HP:0001329
HumanPhenoEEG abnormality

UBA5 GAD1 CACNA2D1 GRIA3 DDB2 LETM1 PARS2 KCNC2 SCN1A SCN2A SCN8A SCN9A DEPDC5 SMS DNM1 CAPRIN1 PIGO

6.38e-045486817HP:0002353
HumanPhenoClonic seizure

CACNA2D1 SCN1A SCN2A SCN8A SCN9A DNM1

6.69e-0481686HP:0020221
HumanPhenoAbnormal electrophysiology of sinoatrial node origin

CACNA2D1 ABCC9 RYR1 RYR2 KCNJ8 DEPDC5

6.69e-0481686HP:0011702
HumanPhenoAbnormality of jaw muscles

RAPSN OBSCN RYR1 SCN4A

6.97e-0431684HP:0045037
HumanPhenoIncoordination

UBA5 CACNA2D1 ATP7B MARS1 SYNE1 SMCHD1 SPTA1 SLC19A3 CHD7 DDB2 LETM1 PARS2 RYR1 RYR3 COL18A1 CSF1R KCNC2 SACS SCN1A SCN2A SCN4A SCN8A SCN9A ZFYVE26 DNM1 CAPRIN1 PIGO AGTPBP1

7.05e-0411846828HP:0002311
HumanPhenoAbnormal muscle fiber-type distribution

RAPSN OBSCN RYR1 RYR3 SCN4A AGTPBP1

7.62e-0483686HP:0033684
HumanPhenoCogwheel rigidity

SLC19A3 SCN1A SCN2A SCN9A

7.88e-0432684HP:0002396
HumanPhenoPes valgus

ANO1 SCN1A SCN2A SCN4A SCN9A

8.24e-0456685HP:0008081
HumanPhenoAbnormal esophagus morphology

UBA5 CACNA2D1 ATP7B HTRA2 FERMT1 OBSCN SLC19A3 LAMA3 CHD7 F5 LETM1 PARS2 SALL1 CSF1R TMTC3 KCNC2 SACS SCN4A SCN8A SCN9A MACF1 ZFYVE26 CEP295 DNM1 CAPRIN1 TNPO3

9.08e-0410786826HP:0002031
HumanPhenoFacial tics

SCN1A SCN2A SCN9A

9.23e-0415683HP:0011468
HumanPhenoPhotosensitive tonic-clonic seizure

SCN1A SCN2A SCN9A

9.23e-0415683HP:0007207
HumanPhenoEpileptic encephalopathy

UBA5 PARS2 KCNC2 SCN1A SCN2A SCN8A DNM1

9.48e-04119687HP:0200134
HumanPhenoFunctional abnormality of the gastrointestinal tract

UBA5 CACNA2D1 ATP7B HTRA2 FERMT1 CD109 OBSCN SLC19A3 ANO1 LAMA3 CHD7 ITGA2B F5 LETM1 PARS2 SALL1 CSF1R TMTC3 KCNC2 SACS SCN4A SCN8A SCN9A MACF1 ZFYVE26 DNM1 SEC61A1 CAPRIN1 TNPO3

9.71e-0412706829HP:0012719
HumanPhenoAbnormal knee physiology

SYNE1 GRIA3 RYR1 SCN1A SCN2A SCN9A

9.78e-0487686HP:0034670
HumanPhenoAnal stenosis

FERMT1 CHD7 SALL1 PIGO

9.96e-0434684HP:0002025
HumanPhenoGeneralized clonic seizure

SCN1A SCN2A SCN8A SCN9A

9.96e-0434684HP:0011169
DomainNa_channel_asu

SCN1A SCN2A SCN4A SCN8A SCN9A

1.05e-08101605IPR001696
DomainNa_trans_assoc

SCN1A SCN2A SCN4A SCN8A SCN9A

1.05e-08101605IPR010526
DomainNa_trans_assoc

SCN1A SCN2A SCN4A SCN8A SCN9A

1.05e-08101605PF06512
DomainNa_trans_cytopl

SCN1A SCN2A SCN8A SCN9A

7.68e-0861604PF11933
DomainNa_trans_cytopl

SCN1A SCN2A SCN8A SCN9A

7.68e-0861604IPR024583
DomainIon_trans_dom

RYR1 RYR2 RYR3 KCNC2 SCN1A SCN2A SCN4A SCN8A SCN9A

5.97e-071141609IPR005821
DomainIon_trans

RYR1 RYR2 RYR3 KCNC2 SCN1A SCN2A SCN4A SCN8A SCN9A

5.97e-071141609PF00520
DomainRyanodine_rcpt

RYR1 RYR2 RYR3

6.17e-0731603IPR003032
DomainRyanrecept_TM4-6

RYR1 RYR2 RYR3

6.17e-0731603IPR009460
DomainRyR

RYR1 RYR2 RYR3

6.17e-0731603PF02026
DomainRR_TM4-6

RYR1 RYR2 RYR3

6.17e-0731603PF06459
DomainRyan_recept

RYR1 RYR2 RYR3

6.17e-0731603IPR013333
DomainDUF2012

NOMO1 NOMO2 NOMO3

2.45e-0641603PF09430
DomainDUF2012

NOMO1 NOMO2 NOMO3

2.45e-0641603IPR019008
DomainChannel_four-helix_dom

KCNC2 SCN1A SCN2A SCN4A SCN8A SCN9A

9.10e-06571606IPR027359
Domain-

KCNC2 SCN1A SCN2A SCN4A SCN8A SCN9A

9.10e-065716061.20.120.350
DomainCarboxyPept-like_regulatory

TENM2 NOMO1 NOMO2 NOMO3

1.13e-05171604IPR008969
DomainRIH_assoc-dom

RYR1 RYR2 RYR3

1.21e-0561603IPR013662
DomainIns145_P3_rec

RYR1 RYR2 RYR3

1.21e-0561603PF08709
DomainRIH_assoc

RYR1 RYR2 RYR3

1.21e-0561603PF08454
DomainRIH_dom

RYR1 RYR2 RYR3

1.21e-0561603IPR000699
DomainIns145_P3_rcpt

RYR1 RYR2 RYR3

1.21e-0561603IPR014821
DomainRyanodine_recept-rel

RYR1 RYR2 RYR3

1.21e-0561603IPR015925
Domain-

RYR1 RYR2 RYR3

1.21e-05616031.25.10.30
DomainRYDR_ITPR

RYR1 RYR2 RYR3

1.21e-0561603PF01365
DomainAnoct_dimer

ANO2 ANO1 ANO7

2.11e-0571603PF16178
DomainAnoct_dimer

ANO2 ANO1 ANO7

2.11e-0571603IPR032394
Domain-

SMCHD1 MORC4 SACS TOP2A

2.26e-052016043.30.565.10
DomainHATPase_C

SMCHD1 MORC4 SACS TOP2A

2.77e-05211604IPR003594
DomainCarb-bd-like_fold

NOMO1 NOMO2 NOMO3

3.35e-0581603IPR013784
DomainSpectrin

SYNE1 SPTA1 ACTN3 MACF1

4.05e-05231604PF00435
DomainIQ

OBSCN SCN1A SCN2A SCN4A SCN8A SCN9A

6.87e-05811606SM00015
DomainMIR

RYR1 RYR2 RYR3

7.08e-05101603PF02815
DomainMIR_motif

RYR1 RYR2 RYR3

7.08e-05101603IPR016093
DomainAnoctamin

ANO2 ANO1 ANO7

7.08e-05101603PF04547
DomainAnoctamin

ANO2 ANO1 ANO7

7.08e-05101603IPR007632
DomainMIR

RYR1 RYR2 RYR3

7.08e-05101603PS50919
DomainMIR

RYR1 RYR2 RYR3

7.08e-05101603SM00472
DomainATP-grasp_RimK-type

RIMKLA RIMKLB

7.29e-0521602IPR013651
DomainSecY_su_dom

SEC61A2 SEC61A1

7.29e-0521602IPR023201
DomainSECY_1

SEC61A2 SEC61A1

7.29e-0521602PS00755
DomainSECY_2

SEC61A2 SEC61A1

7.29e-0521602PS00756
Domain-

SEC61A2 SEC61A1

7.29e-05216021.10.3370.10
DomainTranslocon_Sec61/SecY_plug_dom

SEC61A2 SEC61A1

7.29e-0521602IPR019561
DomainSecY_CS

SEC61A2 SEC61A1

7.29e-0521602IPR030659
DomainPlug_translocon

SEC61A2 SEC61A1

7.29e-0521602PF10559
DomainRimK

RIMKLA RIMKLB

7.29e-0521602PF08443
DomainSecY

SEC61A2 SEC61A1

7.29e-0521602PF00344
DomainRpS6_RimK/Lys_biosynth_LsyX

RIMKLA RIMKLB

7.29e-0521602IPR004666
DomainSecY/SEC61-alpha

SEC61A2 SEC61A1

7.29e-0521602IPR002208
DomainSpectrin_repeat

SYNE1 SPTA1 ACTN3 MACF1

1.04e-04291604IPR002017
DomainIQ_motif_EF-hand-BS

OBSCN SCN1A SCN2A SCN4A SCN8A SCN9A

1.24e-04901606IPR000048
DomainIQ

OBSCN SCN1A SCN2A SCN4A SCN8A SCN9A

1.48e-04931606PS50096
DomainSPEC

SYNE1 SPTA1 ACTN3 MACF1

1.55e-04321604SM00150
DomainSpectrin/alpha-actinin

SYNE1 SPTA1 ACTN3 MACF1

1.55e-04321604IPR018159
DomainCarboxyPept_regulatory_dom

NOMO1 NOMO2 NOMO3

1.66e-04131603IPR014766
Domain-

RIMKLA GART RIMKLB

1.66e-041316033.40.50.20
Domain-

NOMO1 NOMO2 NOMO3

1.66e-041316032.60.40.1120
DomainEF-hand-dom_pair

SPTA1 ACTN3 LETM1 RYR1 RYR2 RYR3 SCN1A SCN8A SCN9A MACF1

1.88e-0428716010IPR011992
DomainDynein_HC_stalk

DNHD1 DNAH10 DNAH14

2.10e-04141603IPR024743
DomainATP_GRASP

RIMKLA GART RIMKLB

2.10e-04141603PS50975
DomainATP-grasp

RIMKLA GART RIMKLB

2.10e-04141603IPR011761
DomainPreATP-grasp_dom

RIMKLA GART RIMKLB

2.10e-04141603IPR016185
DomainMT

DNHD1 DNAH10 DNAH14

2.10e-04141603PF12777
DomainGART_AS

GART ALDH1L1

2.18e-0431602IPR001555
DomainGART

GART ALDH1L1

2.18e-0431602PS00373
DomainPyrdxlP-dep_Trfase_major_sub2

PDXDC1 GAD1 GOT1L1 GCAT

2.47e-04361604IPR015422
DomainDHC_fam

DNHD1 DNAH10 DNAH14

2.60e-04151603IPR026983
DomainDynein_heavy

DNHD1 DNAH10 DNAH14

2.60e-04151603PF03028
DomainDynein_heavy_dom

DNHD1 DNAH10 DNAH14

2.60e-04151603IPR004273
Domain-

RIMKLA GART RIMKLB

2.60e-041516033.30.1490.20
DomainIQ

OBSCN SCN1A SCN4A SCN8A SCN9A

3.58e-04711605PF00612
DomainPyrdxlP-dep_Trfase

PDXDC1 GAD1 GOT1L1 GCAT

4.10e-04411604IPR015424
DomainPyrdxlP-dep_Trfase_major_sub1

PDXDC1 GAD1 GOT1L1 GCAT

4.10e-04411604IPR015421
Domain-

GART ALDH1L1

4.33e-04416023.40.50.170
DomainFormyl_transf_N

GART ALDH1L1

4.33e-0441602IPR002376
DomainFormyl_trans_N

GART ALDH1L1

4.33e-0441602PF00551
DomainATP_grasp_subdomain_1

RIMKLA GART RIMKLB

4.58e-04181603IPR013815
Domain-

RIMKLA GART RIMKLB

4.58e-041816033.30.470.20
Domain-

ARMC3 CUL9 HEATR1 HEATR9 CFAP69 TNPO3 AGTPBP1 ARMC8

6.68e-0422216081.25.10.10
DomainARM-type_fold

ARMC3 CUL9 HEATR1 CLHC1 RYR3 HEATR9 CFAP69 TNPO3 AGTPBP1 ARMC8

6.99e-0433916010IPR016024
DomainGroucho_enhance

TLE1 TLE3

7.17e-0451602IPR009146
Domain-

ALDH1L1 FASN

7.17e-04516021.10.1200.10
DomainTLE_N

TLE1 TLE3

7.17e-0451602PF03920
DomainPHOSPHOPANTETHEINE

ALDH1L1 FASN

7.17e-0451602PS00012
DomainGroucho/TLE_N

TLE1 TLE3

7.17e-0451602IPR005617
DomainPP-binding

ALDH1L1 FASN

7.17e-0451602PF00550
DomainACP_DOMAIN

ALDH1L1 FASN

7.17e-0451602PS50075
DomainDUF1785

PIWIL2 AGO4

7.17e-0451602SM01163
DomainACTININ_2

SYNE1 ACTN3 MACF1

9.63e-04231603PS00020
DomainACTININ_1

SYNE1 ACTN3 MACF1

9.63e-04231603PS00019
DomainActinin_actin-bd_CS

SYNE1 ACTN3 MACF1

9.63e-04231603IPR001589
DomainEFhand_Ca_insen

SPTA1 ACTN3

1.07e-0361602PF08726
DomainArgoL1

PIWIL2 AGO4

1.07e-0361602PF08699
DomainEF-hand_Ca_insen

SPTA1 ACTN3

1.07e-0361602IPR014837
DomainArgoL1

PIWIL2 AGO4

1.07e-0361602IPR014811
DomainPP-bd_ACP

ALDH1L1 FASN

1.07e-0361602IPR009081
DomainPIWI

PIWIL2 AGO4

1.97e-0381602PS50822
DomainPiwi

PIWIL2 AGO4

1.97e-0381602SM00950
DomainPyrdxlP-dep_de-COase

PDXDC1 GAD1

1.97e-0381602IPR002129
PathwayREACTOME_CARDIAC_CONDUCTION

ABCC9 RYR1 RYR2 RYR3 SCN1A SCN2A SCN4A SCN8A SCN9A ATP1A4

2.27e-0713012510M27454
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTA1 SCN1A SCN2A SCN4A SCN8A SCN9A

2.65e-07311256M877
PathwayREACTOME_MUSCLE_CONTRACTION

ABCC9 ACTN3 RYR1 RYR2 RYR3 SCN1A SCN2A SCN4A SCN8A SCN9A ATP1A4

1.87e-0620312511M5485
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN1A SCN2A SCN4A SCN8A SCN9A

8.41e-06321255M27455
PathwayREACTOME_L1CAM_INTERACTIONS

SPTA1 ITGA2B SCN1A SCN2A SCN4A SCN8A SCN9A DNM1

1.19e-051211258M872
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ANO2 ATP7B TTYH2 ANO1 RYR1 RYR2 RYR3 ANO7 ATP1A4

2.65e-051761259MM15718
PathwayREACTOME_STIMULI_SENSING_CHANNELS

ANO2 TTYH2 ANO1 RYR1 RYR2 RYR3 ANO7

2.76e-05991257MM14910
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ANO2 ATP7B TTYH2 ANO1 RYR1 RYR2 RYR3 ANO7 ATP1A4

3.61e-051831259M997
PathwayREACTOME_STIMULI_SENSING_CHANNELS

ANO2 TTYH2 ANO1 RYR1 RYR2 RYR3 ANO7

4.29e-051061257M27200
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

RYR1 RYR2 RYR3

1.07e-04111253M47958
PathwayREACTOME_ION_HOMEOSTASIS

ABCC9 RYR1 RYR2 RYR3 ATP1A4

1.13e-04541255M27460
PathwayREACTOME_ION_HOMEOSTASIS

ABCC9 RYR1 RYR2 RYR3 ATP1A4

1.13e-04541255MM15202
PathwayWP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING

RYR1 RYR2 RYR3

1.82e-04131253M39589
PathwayREACTOME_INDUCTION_OF_CELL_CELL_FUSION

ANO2 ANO1 ANO7

1.82e-04131253M46426
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

RYR1 RYR2 RYR3

5.94e-04191253M47760
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

KRT16 ARMC3 SYNE1 SMCHD1 SPTA1 SRP72 GRIA3 CCT2 HEATR1 ACTN3 LETM1 RYR2 KRT23 SEC61A2 FASN RIMKLB SACS TJP1 FAM186A EIF4A1 SCN4A SCN9A MACF1 BOD1L1 CEP295 ATP1A4 SEC61A1 CFAP69 TOP2A DOP1A

1.01e-1114421663035575683
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

PDXDC1 CACNA2D1 HBS1L MARS1 SMCHD1 GART CD109 SRP72 CCT2 TXNDC12 COL18A1 FASN TMTC3 G3BP1 GCAT NOMO2 TJP1 EIF4A1 MACF1 AKAP13 BOD1L1 TAGLN2 FLOT1 SEC61A1 CAPRIN1 TNPO3 PIGO

1.24e-1012971662733545068
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN2A SCN4A SCN8A SCN9A

2.89e-109166516382098
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

DNHD1 ABCA13 MARS1 TXNDC12 RYR1 EIF4A1 TLN2 BOD1L1 DNM1 SEC61A1 DOP1A

5.63e-092081661133230847
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN2A SCN8A SCN9A

7.45e-096166423652591
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

DNHD1 HBS1L DNAH10 HTRA2 MARS1 SYNE1 SMCHD1 GART SRP72 CCT2 HEATR1 LETM1 NOMO1 NMD3 FASN G3BP1 EIF4A1 TLN2 BOD1L1 TAGLN2 FLOT1 SEC61A1 CAPRIN1 TOP2A ARMC8

1.99e-0814251662530948266
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA2D1 ABCC9 RYR2 KCNC2 SCN1A KCNJ8 SCN4A SCN8A SCN9A

2.49e-08139166916985003
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN2A SCN4A SCN8A

6.19e-089166415746173
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

CACNA2D1 KRT16 MARS1 SYNE1 SPTA1 SRP72 CCT2 ALDH1L1 ACTN3 LETM1 FASN PTPRA G3BP1 SACS TJP1 SCN2A C1QB MACF1 TLN2 DNM1 FLOT1 CAPRIN1 AGTPBP1 ARMC8

9.08e-0814311662437142655
Pubmed

Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.

RYR1 RYR2 RYR3

1.07e-073166318403125
Pubmed

Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.

NOMO1 NOMO2 NOMO3

1.07e-073166336011023
Pubmed

The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

RYR1 RYR2 RYR3

1.07e-07316637876312
Pubmed

Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.

RYR1 RYR2 RYR3

1.07e-073166322948152
Pubmed

Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.

RYR1 RYR2 RYR3

1.07e-073166310788707
Pubmed

Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.

RYR1 RYR2 RYR3

1.07e-07316637621815
Pubmed

Molecular identification of the ryanodine receptor pore-forming segment.

RYR1 RYR2 RYR3

1.07e-073166310473538
Pubmed

Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.

GAD1 SCN1A SCN2A

1.07e-073166328784306
Pubmed

Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.

RYR1 RYR2 RYR3

1.07e-073166318434746
Pubmed

Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex.

GAD1 ANO2 ANO1

1.07e-073166326558388
Pubmed

SPRY domains in ryanodine receptors (Ca(2+)-release channels).

RYR1 RYR2 RYR3

1.07e-07316639204703
Pubmed

Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.

RYR1 RYR2 RYR3

1.07e-073166321881589
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN1A SCN2A SCN8A

1.07e-073166332845893
Pubmed

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

RYR1 RYR2 RYR3

1.07e-073166312213830
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN1A SCN2A SCN8A

1.07e-073166328518218
Pubmed

Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.

RYR1 RYR2 RYR3

1.07e-07316639242641
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN1A SCN2A SCN8A

1.07e-073166317928448
Pubmed

Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.

RYR1 RYR2 RYR3

1.07e-073166325239916
Pubmed

A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.

RYR1 RYR2 RYR3

1.07e-073166318643873
Pubmed

Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).

RYR1 RYR2 RYR3

1.07e-073166311159936
Pubmed

Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.

NOMO1 NOMO2 NOMO3

1.07e-073166325576386
Pubmed

Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.

RYR1 RYR2 RYR3

1.07e-07316637959768
Pubmed

The organization of proteins in the human red blood cell membrane. A review.

RYR1 RYR2 RYR3

1.07e-07316634600883
Pubmed

Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.

RYR1 RYR2 RYR3

1.07e-07316637635066
Pubmed

An ER translocon for multi-pass membrane protein biogenesis.

NOMO1 NOMO2 SEC61A1 NOMO3

1.61e-0711166432820719
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

MARS1 SMCHD1 GART CCT2 ITGA2B CEMIP2 NOMO1 COL18A1 FASN GCAT NOMO2 EIF4A1 COPS6 CAPRIN1 NOMO3

2.87e-076131661522268729
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN2A SCN8A SCN9A

3.46e-0713166415123669
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN2A SCN8A

4.26e-074166317537961
Pubmed

Ryanodine receptor calcium release channels: lessons from structure-function studies.

RYR1 RYR2 RYR3

4.26e-074166323413940
Pubmed

Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.

RYR1 RYR2 RYR3

4.26e-07416639607712
Pubmed

Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.

RYR1 RYR2 RYR3

4.26e-074166323482488
Pubmed

A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.

RYR1 RYR2 RYR3

4.26e-074166318206662
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN2A SCN8A

4.26e-074166335031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN2A SCN8A

4.26e-074166329578003
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN1A SCN2A SCN8A

4.26e-074166321156207
Pubmed

Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.

NOMO1 NOMO2 NOMO3

4.26e-074166331833031
Pubmed

Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.

RYR1 RYR2 RYR3

4.26e-07416639384575
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

GAD1 SCN1A SCN2A

4.26e-07416638974318
Pubmed

A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.

NOMO1 NOMO2 NOMO3

4.26e-07416639267806
Pubmed

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.

DAB2IP FASTKD1 ZDHHC5 GRIA3 TENM2 GCAT TJP1 SCN1A MACF1

4.92e-07197166936604605
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DAB2IP TTC28 SYNE1 CUL9 TENM2 ADCY3 TBC1D1 TLE3 MACF1 BOD1L1 AGTPBP1 PDZD2

6.77e-074071661212693553
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

HBS1L SMCHD1 HEATR1 G3BP1 SACS TJP1 MACF1 TLN2 BOD1L1 SMS TAGLN2 TNPO3 TOP2A

8.99e-074981661336634849
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

NR2C1 TTC28 SYNE1 CUL9 CCT2 RYR3 PTPRA FBH1 SACS NOMO2 TJP1 EIF4A1 MACF1 TLN2 EIF2AK1 DNM1 FLOT1 LNX1 CAPRIN1 AGTPBP1 ARMC8

9.46e-0712851662135914814
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN1A SCN2A SCN9A

1.06e-06516638812438
Pubmed

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.

RYR1 RYR2 RYR3

1.06e-065166323918386
Pubmed

Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.

RYR1 RYR2 RYR3

1.06e-065166319011160
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN4A SCN8A

1.06e-065166317724025
Pubmed

Network organization of the human autophagy system.

UBA5 STX8 HTRA2 CCT2 DDB2 PARS2 SEC61A2 COL18A1 PTPRA G3BP1 TJP1 PI4KB

1.42e-064371661220562859
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

DNAH10 SYNE1 SPTA1 CCDC168 RYR2 RYR3 PTPRA AKAP13

1.58e-06168166830631154
Pubmed

Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.

RYR1 RYR2 RYR3

2.11e-066166319549818
Pubmed

Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.

RYR1 RYR2 RYR3

2.11e-066166326025922
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

RYR1 RYR2 RYR3

2.11e-066166323463619
Pubmed

FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.

RYR1 RYR2 RYR3

2.11e-066166314592808
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

RYR1 RYR2 RYR3

2.11e-066166325966694
Pubmed

HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

RYR1 RYR2 RYR3

2.11e-066166319009018
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

RYR1 RYR2 RYR3

2.11e-066166320519450
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

RYR1 RYR2 RYR3

2.11e-066166316844763
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

CACNA2D1 KRT16 MARS1 SYNE1 SMCHD1 GART CCT2 HEATR1 F5 FASN G3BP1 SACS TJP1 EIF4A1 MACF1 TAGLN2 FLOT1 TOP2A

2.19e-0610241661824711643
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

ZNF143 TTC28 ACADSB CHD7 MORC4 RYR1 RYR2 RAD51AP2 SALL1 TMTC3 PI4KB TLE3 CEP295 NOMO3

2.59e-066381661431182584
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

STX8 ACADSB SYNE1 ZDHHC5 HEATR1 LETM1 CEMIP2 NOMO1 SEC61A2 COL18A1 AIFM2 TMTC3 SACS NOMO2 MACF1 AKAP13 AKAP11 VAMP8 FLOT1 SEC61A1 CAPRIN1 AGTPBP1

2.60e-0614871662233957083
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

SCN1A SCN2A SCN8A

3.69e-067166325818041
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

RYR1 RYR2 RYR3

3.69e-067166311860456
Pubmed

ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.

ANO2 ANO1 ANO7

3.69e-067166322075693
Pubmed

Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.

RYR1 RYR2 RYR3

3.69e-067166320962236
Pubmed

Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.

KRT16 CCT2 NOMO1 FASN TJP1 MACF1 FLOT1 NOMO3

4.11e-06191166833762435
Pubmed

Wnt signaling regulates ion channel expression to promote smooth muscle and cartilage formation in developing mouse trachea.

ANO1 ABCC9 KCNC2 KCNJ8

4.13e-0623166437873566
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

UBA5 SMCHD1 FERMT1 SRP72 CCT2 CHD7 TRUB1 FASN EIF4A1 MACF1 TLN2 COPS6 TOP2A

4.94e-065821661320467437
Pubmed

The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels.

ANO2 ANO1 ANO7

5.88e-068166321984732
Pubmed

Expression and function of epithelial anoctamins.

ANO2 ANO1 ANO7

5.88e-068166320056604
Pubmed

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.

RYR1 RYR2 RYR3

5.88e-068166311784029
Pubmed

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.

NOMO1 NOMO2 NOMO3

5.88e-068166315257293
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

RYR1 RYR2 RYR3

5.88e-068166319033399
Pubmed

Evolutionarily conserved regulators of tau identify targets for new therapies.

PDXDC1 STX8 ATP7B CCT2 NOMO1 FASN NOMO2 EIF4A1 TAGLN2 VAMP8 SEC61A1 NOMO3

7.73e-065161661236610398
Pubmed

Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.

KRT16 MARS1 SMCHD1 GART CCT2 HEATR1 FASN G3BP1 EIF4A1 MACF1 TAGLN2 VAMP8 FLOT1 TOP2A

8.34e-067071661419738201
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

PDXDC1 MARS1 SYNE1 SPTA1 GART CCT2 ALDH1L1 RYR1 FASN EIF4A1 SCN8A MACF1 AKAP13 SMS TAGLN2

8.35e-068071661530575818
Pubmed

Substrate-driven assembly of a translocon for multipass membrane proteins.

NOMO1 NOMO2 NOMO3

8.78e-069166336261522
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

PDXDC1 ACADSB HTRA2 MARS1 GART CCT2 MORC4 WTAP NOMO1 SEC61A2 FASN G3BP1 GCAT NOMO2 EIF4A1 PIPSL COPS6 SEC61A1 NOMO3

9.82e-0612571661937317656
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

NR2C1 ATP7B TTC28 CHD7 CEMIP2 TMTC3 NOMO2 TJP1 TLE1 AKAP13 BOD1L1 CEP295 VAMP8 AGTPBP1

1.25e-057331661434672954
Pubmed

Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.

ANO2 ANO1 ANO7

1.25e-0510166323532839
Pubmed

Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.

ANO2 ANO1 ANO7

1.25e-0510166319015192
Pubmed

Structure and function of TMEM16 proteins (anoctamins).

ANO2 ANO1 ANO7

1.25e-0510166324692353
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

DAB2IP TTC28 SYNE1 CHD7 TBC1D1 MACF1 TLN2 AKAP11

1.36e-05225166812168954
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

ACADSB ABCA13 SMCHD1 CHD7 HEATR1 TENM2 RYR1 KRT23 KAT7 TJP1 AKAP11 NOMO3

1.51e-055521661210737800
Pubmed

Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.

CCT2 NOMO1 NOMO2 AKAP11 LNX1 NOMO3

1.53e-05110166627889896
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

SMCHD1 GART CUL9 SRP72 CCT2 CHD7 HEATR1 FASN G3BP1 TJP1 EIF4A1 MACF1 CAPRIN1

1.67e-056531661322586326
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

SMCHD1 GART CD109 ZDHHC5 HEATR1 F5 KAT7 TJP1 EIF4A1 MACF1 FLOT1 CAPRIN1 TOP2A

1.87e-056601661332780723
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

PDXDC1 SMCHD1 CD109 HEATR1 NOMO1 TYK2 FASN PTPRA TMTC3 TJP1 SMS TAGLN2 PIPSL SEC61A1 TNPO3 ARMC8

1.90e-059741661628675297
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

PDXDC1 ZNF143 FASTKD1 GART CD109 CCT2 PLA2G2E TXNDC12 NOMO1 FASN TMTC3 GCAT NOMO2 TJP1 TLE1 EIF4A1 VAMP8 SEC61A1 PIGO NOMO3

2.14e-0514511662030550785
Pubmed

Charting the landscape of tandem BRCT domain-mediated protein interactions.

DNHD1 SMCHD1 ZDHHC5 SYCP3 NOMO1 FASN G3BP1 TBC1D1 EIF4A1 TAGLN2 EIF2AK1 SEC61A1 NOMO3

2.19e-056701661322990118
Pubmed

Fatty acid synthase regulates the pathogenicity of Th17 cells.

IL17F FASN

2.26e-052166228848043
Pubmed

Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.

SCN1A SCN8A

2.26e-052166237901435
InteractionSOX6 interactions

NR2C1 SMCHD1 CHD7 MORC4 G3BP1 TLE1 TLE3 FLOT1 CAPRIN1

5.68e-061571649int:SOX6
InteractionFBXO6 interactions

MARS1 SMCHD1 GART CD109 LAMA3 CCT2 ITGA2B CEMIP2 NOMO1 COL18A1 FASN TMTC3 GCAT NOMO2 EIF4A1 COPS6 CAPRIN1 NOMO3

2.30e-0571716418int:FBXO6
InteractionCCDC8 interactions

CACNA2D1 KRT16 MARS1 SMCHD1 GART CUL9 CCT2 HEATR1 F5 FASN G3BP1 SACS TJP1 EIF4A1 MACF1 FLOT1 TOP2A

2.64e-0565616417int:CCDC8
InteractionKCNA3 interactions

DNHD1 HBS1L TTC28 ABCA13 MARS1 GART ZDHHC5 SRP72 CCT2 LETM1 RYR1 FASN EIF4A1 MACF1 TLN2 BOD1L1 TAF7 DNM1 SEC61A1 DOP1A

2.83e-0587116420int:KCNA3
InteractionSCN4B interactions

SCN1A SCN2A SCN8A

2.88e-0581643int:SCN4B
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN2A SCN4A SCN8A SCN9A

1.03e-09911251203
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR1 RYR2 RYR3

2.31e-0731123287
GeneFamilyAnoctamins

ANO2 ANO1 ANO7

2.69e-05101123865
GeneFamilyArgonaute/PIWI family

PIWIL2 AGO4

1.04e-0381122408
GeneFamilyPDZ domain containing

HTRA2 TAX1BP3 TJP1 LNX1 PDZD2

2.56e-0315211251220
GeneFamilyATP binding cassette subfamily C

ABCC9 ABCC12

2.84e-03131122807
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

FERMT1 TYK2 TLN2

3.67e-035011231293
GeneFamilyDyneins, axonemal

DNAH10 DNAH14

4.87e-03171122536
GeneFamilyDNA helicases

CHD7 FBH1

4.87e-031711221167
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

ITGA2B RYR1 SACS TMEM132D AKAP11

5.39e-031811125694
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO2 DNAH10 ABCA13 SPTA1 OBSCN RYR2 RYR3 SCN2A SCN9A TLN2 ONECUT3 ATP1A4

5.76e-12184167122cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO2 DNAH10 ABCA13 SPTA1 OBSCN RYR2 RYR3 SCN2A SCN9A TLN2 ONECUT3 ATP1A4

5.76e-1218416712ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO2 DNAH10 ABCA13 SPTA1 OBSCN RYR2 RYR3 SCN2A SCN9A TLN2 ONECUT3 ATP1A4

5.76e-12184167122b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DAB2IP TTYH2 OBSCN ANO1 ABCC9 ADCY3 RYR2 COL18A1 TJP1 EGFLAM

2.43e-0918716710a2bf958ea59c359a265bfa437d59315e1920cdd4
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

GAD1 OBSCN TENM2 RYR2 FASN CSF1R KCNC2 SCN2A SCN9A ARHGAP20

4.64e-09200167105c7263c862093ad9dbc81d06b16b6f74e8a6b634
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DAB2IP TTYH2 ANO1 ABCC9 ADCY3 RYR2 COL18A1 TJP1 EGFLAM

3.54e-081851679a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 GRIA3 TENM2 RYR2 KCNC2 SCN1A SCN2A SCN8A DNM1

6.34e-0819816796d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.

GAD1 OBSCN RYR2 FASN CSF1R KCNC2 SCN2A SCN9A ARHGAP20

6.91e-08200167961d7dd0a78942b069c3f5e75044368dc00e6e8e6
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB2 ABCA13 SYNE1 CEMIP2 CSF1R TBC1D1 TLE3 PDZD2

3.34e-071751678cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCellfacs-Heart-LV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTYH2 ANO1 ABCC9 CLHC1 TBC1D1 KCNJ8 EGFLAM PDZD2

4.31e-0718116781db1eb7d330a7e5090994007ae287e11f0a74450
ToppCellfacs-Heart-LV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTYH2 ANO1 ABCC9 CLHC1 TBC1D1 KCNJ8 EGFLAM PDZD2

4.31e-07181167806174ce9240c9261c0f51a1b0d875335d60722e5
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT16 GRIA3 RYR2 KCNC2 SCN1A SCN2A SCN8A DNM1

5.30e-0718616787278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCellMesenchymal-pericyte_cell|World / Lineage, Cell type, age group and donor

TTYH2 OBSCN ABCC9 ADCY3 RYR2 COL18A1 TJP1 EGFLAM

5.99e-071891678d7ed96add29f219183c802895fbff519b627f635
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA2D1 GRIA3 RYR2 KCNC2 SCN1A SCN2A SCN8A DNM1

7.01e-071931678be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA2D1 GRIA3 RYR2 KCNC2 SCN1A SCN2A SCN8A DNM1

7.01e-0719316780c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA2D1 GRIA3 RYR2 KCNC2 SCN1A SCN2A SCN8A DNM1

7.01e-0719316788689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 GRIA3 TENM2 RYR2 KCNC2 SCN2A SCN8A DNM1

7.88e-071961678676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 TENM2 RYR2 KCNC2 SCN1A SCN2A SCN8A DNM1

8.50e-071981678c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 GRIA3 RYR2 KCNC2 SCN1A SCN2A SCN8A DNM1

8.50e-0719816784ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

GAD1 FERMT1 GRIA3 TMEM132D SCN1A SCN2A SCN9A PDZD2

9.17e-072001678f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

GAD1 FERMT1 GRIA3 TMEM132D SCN1A SCN2A SCN9A PDZD2

9.17e-072001678cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

GAD1 FERMT1 GRIA3 TMEM132D SCN1A SCN2A SCN9A PDZD2

9.17e-072001678c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

GAD1 FERMT1 GRIA3 TMEM132D SCN1A SCN2A SCN9A PDZD2

9.17e-0720016784fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

GAD1 FERMT1 GRIA3 TMEM132D SCN1A SCN2A SCN9A PDZD2

9.17e-072001678310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

GAD1 FERMT1 GRIA3 TMEM132D SCN1A SCN2A SCN9A PDZD2

9.17e-072001678961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-T_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

F5 COL18A1 FASN PTPRA TMEM132D EGFLAM FBXO32

1.61e-061501677c922dbb4c9c12ccf08bd5f6168b20606c605d052
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 FERMT1 LAMA3 CCDC168 F5 TENM2 DNM1

2.28e-061581677e7db0ee4740e3c7a4d97d7cd7462e2c2ab458a4b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 FERMT1 LAMA3 CCDC168 F5 TENM2 DNM1

2.28e-061581677d39e020c3e77eb9d3de600a171d22f94357061d4
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPLD1 ABCA13 SYNE1 GCAT TLN2 FLOT1 TOP2A

3.29e-0616716771bd27ffe381d26731b6d4cc5f29b27f1bac4473b
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 ABCA13 SPTA1 RYR2 RYR3 KRT23 SCN9A

3.56e-06169167712bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTYH2 ANO1 ABCC9 ADCY3 TBC1D1 KCNJ8 EGFLAM

4.15e-061731677d78397e65e997ddb995111a810f0e2a4f67d0765
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTYH2 ANO1 ABCC9 ADCY3 TBC1D1 KCNJ8 EGFLAM

4.15e-0617316773c852ffe22f4a5b632463086b08c669310684e80
ToppCellCOVID-19-Heart-VSMC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ANO1 ADCY3 COL18A1 TBC1D1 TLE1 EGFLAM FBXO32

4.48e-0617516771125f0d3a5b2388fa77a820dea0288e824d84a82
ToppCellRV-11._Adipocyte|World / Chamber and Cluster_Paper

SLC19A3 ALDH1L1 FASN AIFM2 TLE1 TLN2 ARHGAP20

4.83e-061771677f0edf04930692418953e4f00a917257804ec0ffd
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABCC9 RYR2 COL18A1 KCNJ8 TLN2 EGFLAM TAGLN2

5.01e-061781677e5e4742e35c3d90f82b830d77bdbdc45828c7deb
ToppCellRA-07._Pericyte|RA / Chamber and Cluster_Paper

ANO1 LAMA3 ABCC9 ADCY3 TLE1 EGFLAM PDZD2

5.59e-0618116778dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCellCOVID-19-Heart-Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA2D1 ANO1 ABCC9 ADCY3 KCNJ8 EGFLAM PDZD2

5.59e-06181167733cac65ed1ea5e7bd72250495df4f850b143d5aa
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPLD1 ATP7B F5 SLC22A18 COL18A1 HSD3B2 TMEM82

5.80e-061821677770ce9f3f4538d0181a0181543841bc964c68274
ToppCellCOVID-19-Heart-EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

ANO2 ANO1 ABCC9 ADCY3 KCNJ8 EGFLAM PDZD2

5.80e-061821677e67f3234165199085c793915ebb1f9bbd845e933
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPLD1 ATP7B F5 SLC22A18 COL18A1 HSD3B2 TMEM82

5.80e-06182167777ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPLD1 ATP7B F5 SLC22A18 COL18A1 HSD3B2 TMEM82

5.80e-0618216774921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCellLA-07._Pericyte|World / Chamber and Cluster_Paper

ANO1 ABCC9 ADCY3 TLE1 KCNJ8 EGFLAM PDZD2

6.01e-061831677e3835db4795362b0442d5893baf2a78efcc20428
ToppCellCOVID-19-Heart-Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

ANO1 ABCC9 ADCY3 TLE1 KCNJ8 EGFLAM PDZD2

6.23e-06184167721790cdfa3b4036ad413fd44b94e31563116f25f
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANO1 ABCC9 ADCY3 RYR2 KCNJ8 EGFLAM PDZD2

6.23e-061841677327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCellPBMC-Mild-cDC_9|Mild / Compartment, Disease Groups and Clusters

HEATR1 PARS2 CSF1R TJP1 SCN8A C1QB TOP2A

6.23e-0618416772e0c9a2c40c892a2d435eafb31f1f838de9baf15
ToppCellfacs-Skin-nan-24m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAPSN ABCA13 ABCC9 KCNJ8 DNM1 ARHGAP20 CFAP69

6.45e-0618516778433a337625ff8398520e223ef92bf9bb0beb14c
ToppCellfacs-Skin-nan-24m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAPSN ABCA13 ABCC9 KCNJ8 DNM1 ARHGAP20 CFAP69

6.45e-061851677049d793d043d5d434f143025de49dd210d18756c
ToppCellfacs-Skin-nan-24m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAPSN ABCA13 ABCC9 KCNJ8 DNM1 ARHGAP20 CFAP69

6.45e-06185167763200c42565eea596f9b00728e70e544b8d50a7f
ToppCell3'_v3-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

SYNE1 SMCHD1 PIWIL2 CEMIP2 MACF1 ONECUT3

6.46e-06121167619333a660800b583fa27b495c1f7828e6636a257
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANO1 ABCC9 ADCY3 COL18A1 TJP1 KCNJ8 EGFLAM

6.68e-0618616776568358812f0ca4e0161a1a1b29682fbced35c79
ToppCellE17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TTYH2 ABCC9 TBC1D1 KCNJ8 SCN8A EGFLAM PDZD2

7.42e-06189167726cfe5b7e7f477f225f4e9f25f983f432f01e183
ToppCellE17.5-Mesenchymal-developing_mesenchymal_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TTYH2 ABCC9 TBC1D1 KCNJ8 SCN8A EGFLAM PDZD2

7.68e-0619016772ab604d35456beba71c25511e0f819000e6642d2
ToppCell3'-Child09-12-SmallIntestine-Mesenchymal-Pericytes-Pericyte|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPTA1 ANO1 ABCC9 ADCY3 COL18A1 KCNJ8 EGFLAM

7.68e-061901677136ca6da77a202874376af193a1dd71d810c76c4
ToppCellCOVID-19-Heart-EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

ANO2 ANO1 ABCC9 ADCY3 TLE1 EGFLAM PDZD2

7.68e-061901677a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCellcontrol-Myeloid-Neutrophils_1|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SMCHD1 KRT23 COL18A1 TLE3 BOD1L1 TAGLN2 STK40

7.95e-061911677db1b3cd07d7d190155b2d14e82e1d124975fbd0b
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

IL12RB2 SMCHD1 HEATR1 CEMIP2 NOMO2 MACF1 AGTPBP1

7.95e-0619116779454f642c3621370fa23640b631301346b300950
ToppCell(7)_Epithelial_cells-(7)_Epithelial-H_(AT1)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

KRT16 FERMT1 CD109 TMPRSS4 DDB2 COL18A1 FBXO32

8.22e-0619216777a6dd2ae217b8f8e460d47ad128904408299458c
ToppCellfacs-Aorta-Heart-3m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 LAMA3 CEMIP2 C1QB MACF1 BOD1L1 CAPRIN1

8.22e-0619216771ccc47792edf9ee23501c8e2165d11271636b66a
ToppCellcellseq2-Epithelial-Epithelial_Airway-Basal/Suprabasal|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KRT16 ABCA13 FERMT1 CD109 TMPRSS4 RYR1 TAX1BP3

8.50e-0619316777c34abdcb8839b9fb25457a79af6c5e7b9714b21
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

ARMC3 ABCA13 SYNE1 TMPRSS4 MACF1 CFAP69 TOP2A

9.40e-061961677af4cdc61830685a888a1209826c23bcf54a43084
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-Pericytes-Immature_pericyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABCC9 COL18A1 TBC1D1 KCNJ8 TLN2 EGFLAM TAGLN2

9.40e-061961677c16fbd23d9e117831b55ab3da5b08b22dd972432
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

ARMC3 ABCA13 SYNE1 TMPRSS4 MACF1 CFAP69 TOP2A

9.40e-0619616776d02d494196e3f857d53eea46d9419690d43beca
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes-Immature_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANO1 ABCC9 ADCY3 COL18A1 TJP1 KCNJ8 EGFLAM

9.72e-061971677fd65a9b41df618ff2a09d76dcf9f1ca3f3bdf52a
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Pericyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ABCC9 ADCY3 COL18A1 TJP1 KCNJ8 EGFLAM PDZD2

9.72e-06197167744cd1ece3633a31e8c9b667cd3cbc2749c06f478
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 TENM2 RYR2 SCN1A SCN2A SCN8A DNM1

1.00e-0519816778ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

SYNE1 TENM2 RYR2 KCNC2 SCN2A SCN8A DNM1

1.07e-05200167748d801219bc771d6c7e151dc88ca4c179988de85
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD1 ANO1 LAMA3 CHD7 ALDH1L1 RYR3 SALL1

1.07e-052001677501a3b93624df463458a35d3e6648d4ccc941724
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2-L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD1 ANO1 LAMA3 CHD7 ALDH1L1 RYR3 SALL1

1.07e-052001677d1f36a8232411933b1494168ec912fd0e5246428
ToppCell3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

SYNE1 SMCHD1 CEMIP2 MACF1 AKAP13 TOP2A

1.21e-051351676ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_large-bowel / Manually curated celltypes from each tissue

SMCHD1 ADCY3 CEMIP2 SLC22A18 COL18A1 DOP1A

2.37e-05152167695944864ce7539ff8de028f5700694931338f3ff
ToppCellmild_COVID-19_(asymptomatic)-MAIT|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

IL12RB2 KRT23 TMTC3 TLE1 SCN4A TLN2

2.46e-05153167626852f3d8f80e102e24bcb90e24aac26fdc9a32c
ToppCellCOVID-19-Heart-CM_5_(RYR2-)|Heart / Disease (COVID-19 only), tissue and cell type

IL12RB2 RAPSN ACTN3 RYR1 SCN4A FBXO32

2.64e-051551676d7e26696fd9c0a759524f331243db43059b33ed9
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA2D1 DNAH10 PIWIL2 TENM2 SCN9A TLN2

2.94e-051581676f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA2D1 DNAH10 PIWIL2 TENM2 SCN9A TLN2

2.94e-0515816768c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IL12RB2 CUL9 GRIA3 F5 AIFM2 CSF1R

3.05e-051591676b05fda31b77536a1878f55d3199563b53f9420b2
ToppCellsevere_COVID-19-pDC|severe_COVID-19 / disease group, cell group and cell class (v2)

IL12RB2 TTC28 RYR1 NOMO1 GCAT SCN9A

3.05e-051591676ea5088d27e42b8850455764d53b757ea8d8f14bc
ToppCellChildren_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA2D1 ANO1 RYR2 RAD51AP2 KCNC2 TBC1D1

3.75e-0516516768a82e20c9b1156bb4bbc16f7785abb04458d671b
ToppCellLV-11._Adipocyte|World / Chamber and Cluster_Paper

SLC19A3 ALDH1L1 FASN AIFM2 TLE1 ARHGAP20

3.88e-0516616767e5852891714465c6228c9f955fd511ec79d0e02
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-enterocyte_of_epithelium_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 LAMA3 CSF1R TJP1 AKAP13 FBXO32

4.15e-05168167603896466698a79f7f1ad862cb7e05585260e2a5a
ToppCellmild_COVID-19-HSPC|mild_COVID-19 / disease group, cell group and cell class (v2)

SPTA1 FERMT1 CD109 LAMA3 CFAP69 PDZD2

4.15e-05168167690b33962adb77d8326dee403712118398b4d1315
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GPLD1 RAPSN OBSCN ABCC9 KCNJ8 ATP1A4

4.15e-051681676d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPLD1 ABCA13 SYNE1 TLN2 FLOT1 TOP2A

4.15e-051681676faaba5ac01c2ebe380f56559374a121979a85a13
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RAPSN ABCA13 CHD7 COL18A1 TLE3 SCN9A

4.29e-0516916762456b3e7776e8a2214972be1b4d66a3ca5480ae0
ToppCellAdult-Immune-enucleated_erythrocyte-D122|Adult / Lineage, Cell type, age group and donor

IL12RB2 HTRA2 RIMKLA ITGA2B TAX1BP3 NOMO3

4.29e-051691676d5624e5b3687bd3f18f3a2b47a94d11eb1fbdb75
ToppCellP28-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ATP7B TMPRSS4 PIWIL2 KRT23 FASN VAMP8

4.43e-051701676d0ed3a8a7ad96c05641ec409b0a69c4fb094893c
ToppCelldroplet-Skin-nan-18m-Epithelial-keratinocyte_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA2D1 KRT16 SLC19A3 F5 ARHGAP20 TMEM82

4.43e-05170167610e0912dd0beab5d0bbe2bd49e477b5962687925
ToppCellControl-Fibroblasts-Pericytes|Control / group, cell type (main and fine annotations)

CACNA2D1 OBSCN ADCY3 RYR2 COL18A1 EGFLAM

4.58e-051711676080003f698f867935c2bfc55d241d3650f45a0ab
ToppCellCOVID-19-Heart-T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

IL12RB2 CATSPERD SPTA1 RYR1 RYR3 TMEM132D

4.58e-051711676b2e753e811a7639956994609f73efcdb62d04f82
ToppCellLV-11._Adipocyte|LV / Chamber and Cluster_Paper

SLC19A3 ALDH1L1 FASN AIFM2 TLE1 ARHGAP20

4.89e-051731676c2d3fcb3de71015d03d14c63450853d2b03ffa71
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAD1 CACNA2D1 TMPRSS4 RAD51AP2 AKAP11 DOP1A

5.05e-051741676f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellfacs-Heart-LV-24m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTYH2 MEIOB ANO1 ABCC9 KCNJ8 EGFLAM

5.05e-051741676a0a059bb2a64d7011e206db2ebcdf3eb655a925a
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DAB2IP ANO1 ABCC9 ADCY3 RYR2 COL18A1

5.05e-051741676015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCellfacs-Heart-LV-24m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTYH2 MEIOB ANO1 ABCC9 KCNJ8 EGFLAM

5.05e-0517416767cd6f9103133f8d7b90f9ff4b3b0b078cf554542
ToppCellfacs-Heart-RV-24m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTYH2 ANO1 ABCC9 ADCY3 KCNJ8 SCN9A

5.21e-051751676bfac175b79bb7d3d81074a2407c206a7647ee75d
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TTYH2 ABCC9 KCNJ8 EGFLAM TOP2A PDZD2

5.21e-051751676fa16c6ba08dc0cc22e8cf049db0577811d080df6
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTYH2 CHD7 WTAP CSF1R MACF1 AKAP13

5.21e-0517516761ea6cf9da26601646f57fa14d558a5e9e1f0b345
ToppCellfacs-Heart-RV-24m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTYH2 ANO1 ABCC9 ADCY3 KCNJ8 SCN9A

5.21e-051751676c94fb35bbac95123201ca87ca835aecaefc0c490
ToppCellCOVID-19-Myeloid-MoAM4|COVID-19 / Condition, Lineage and Cell class

CD109 DNAH14 RYR1 CSF1R C1QB ATP1A4

5.55e-051771676ca5d0c3d5c700bbe4c2da068eb02be6229afb9a0
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAD1 CACNA2D1 TMPRSS4 RAD51AP2 TMTC3 AKAP11

5.73e-051781676fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell10x5'v1-week_17-19-Hematopoietic-erythroid-early_erythroid|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

GAD1 ATP7B SPTA1 TMPRSS4 RYR3 GCAT

5.91e-0517916763f73f89905c061ada4e3eb921fa394d95f95c959
Drugchloro-m-cresol

CACNA2D1 RYR1 RYR2 RYR3

3.85e-0861644CID000012008
DrugAzumoleno

CACNA2D1 RYR1 RYR2 RYR3

8.93e-0871644CID000056259
Drug1,2-dichlorohexafluorocyclobutane

GRIA3 RYR1 RYR2 RYR3 SCN2A SCN4A

2.46e-07371646CID000009643
Drugcis-diammineplatinum(II

RYR1 RYR2 RYR3

3.67e-0731643CID000159790
Drug2-hydroxyheptanoic acid

RYR1 RYR2 RYR3

3.67e-0731643CID002750949
Drug8N3-cADPR

RYR1 RYR2 RYR3

3.67e-0731643CID000127713
Drugaminodantrolene

RYR1 RYR2 RYR3

3.67e-0731643CID009570289
Drug2-hydroxycarbazole

RYR1 RYR2 RYR3

3.67e-0731643CID000093551
DrugRyanodyl 3-(pyridine-3-carboxylate

RYR1 RYR2 RYR3

3.67e-0731643CID005748312
DrugPCB74

RYR1 RYR2 RYR3

1.46e-0641643CID000036218
Drug148504-47-6

RYR1 RYR2 RYR3

1.46e-0641643CID006444275
DrugSC 38249

RYR1 RYR2 RYR3

1.46e-0641643CID000134834
DrugAC1L1U7A

RYR1 RYR2 RYR3

1.46e-0641643CID000035682
DrugLOPAC

RYR1 RYR2 RYR3 PI4KB SCN2A

2.25e-06301645CID000062696
DrugFPL 64176

CACNA2D1 RYR1 RYR2 RYR3

3.33e-06151644CID000003423
Drugsodium

CACNA2D1 ZNF143 ATP7B SLC2A7 GART TMPRSS4 GRIA3 ADCY3 RYR1 RYR2 RYR3 NOMO1 KAT7 SACS TJP1 KCNJ8 SCN2A SCN4A SCN9A ATP1A4 LNX1

4.54e-0694416421CID000000923
DrugZonisamide

SCN1A SCN2A SCN4A SCN9A

5.74e-06171644DB00909
DrugAPETx1, Anthopleura elegantissima

SCN2A SCN4A SCN8A

7.22e-0661643ctd:C475726
DrugMBED

RYR1 RYR2 RYR3

7.22e-0661643CID000129958
DrugAC1O528X

RYR1 RYR2 RYR3

7.22e-0661643CID006475857
DrugNSC114784

RYR1 RYR2 RYR3

7.22e-0661643CID000419425
Drugisradipine

CACNA2D1 HTRA2 RYR1 RYR2 RYR3 SCN4A SCN9A

8.08e-061001647CID000003784
Drugflecainide

CACNA2D1 RYR1 RYR2 RYR3 SCN4A SCN9A

1.24e-05711646CID000003355
Drug[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate

RYR1 RYR2 RYR3

1.26e-0571643CID009547999
DrugBr2BAPTA

RYR1 RYR2 RYR3

1.26e-0571643CID003081001
DrugCHEBI:564108

CACNA2D1 RYR1 RYR3

1.26e-0571643CID006400637
Drugindo-1/AM

CACNA2D1 RYR1 RYR2 RYR3

1.41e-05211644CID000123918
Druglamotrigine

CACNA2D1 RYR1 RYR2 RYR3 SCN2A SCN4A SCN9A

2.14e-051161647CID000003878
Drugetridiazole

SPTA1 RYR1 RYR2 RYR3 SCN4A

2.97e-05501645CID000017432
Drugtetracaine

ADCY3 RYR1 RYR2 RYR3 SCN4A SCN9A

4.24e-05881646CID000005411
DrugPCB 95

RYR1 RYR2 RYR3

4.24e-05101643CID000038012
Drug5'-adenylyl (beta,gamma-methylene)diphosphonate

RYR1 RYR3

5.16e-0521642ctd:C005147
Drugmu-conotoxin KIIIA, Conus kinoshitai

SCN2A SCN4A

5.16e-0521642ctd:C502265
DrugNSC7524

CACNA2D1 ADCY3 RYR1 RYR2 RYR3 SCN2A SCN4A SCN9A

5.40e-051821648CID000005657
DrugPCB 66

RYR1 RYR2 RYR3

5.80e-05111643CID000036185
DrugR 478

RYR1 RYR2 RYR3

5.80e-05111643CID000084223
Drug8-amino-cADPR

RYR1 RYR2 RYR3

5.80e-05111643CID003081323
DrugM-HN

ZNF143 RYR1 RYR2 RYR3

7.02e-05311644CID000015450
DrugRyanodine

RYR1 RYR2 RYR3

7.70e-05121643ctd:D012433
DrugIsoxsuprine hydrochloride [579-56-6]; Down 200; 11.8uM; HL60; HG-U133A

UBA5 NR2C1 HTRA2 GART SRP72 CCT2 NMD3 CAPRIN1

8.76e-0519516481985_DN
DrugCNS 1145

CACNA2D1 RYR1 RYR2 RYR3

9.02e-05331644CID000190902
DrugIHC-64

CACNA2D1 RYR1 RYR2 RYR3

9.02e-05331644CID000162753
DrugRimexolone [49697-38-3]; Down 200; 10.8uM; MCF7; HT_HG-U133A

NR2C1 HBS1L ACADSB FERMT1 PTPRA PI4KB EIF2AK1 PIGO

9.08e-0519616483516_DN
DrugCO(2

STX8 GAD1 CACNA2D1 MARS1 GART ALDH1L1 ADCY3 TYK2 GOT1L1 FASN GCAT

9.74e-0537816411CID000000280
DrugQuinethazone [73-49-4]; Up 200; 13.8uM; PC3; HT_HG-U133A

GPLD1 CACNA2D1 ALDH1L1 ITGA2B F5 CSF1R TLE1 TLN2

9.74e-0519816484529_UP
Drugsuccinylcholine

CACNA2D1 RYR1 RYR2 RYR3 SLC22A18

9.87e-05641645CID000005314
Drugaprikalim

SYNE1 SACS KCNJ8

9.95e-05131643CID003034038
Drugdiphenidol

STX8 SYNE1 GART

9.95e-05131643CID000003055
Drugciguatoxin

STX8 TLE1 SCN4A SCN9A

1.14e-04351644CID005311333
Drugpotassium

CACNA2D1 RAPSN SYNE1 SPTA1 GART ABCC9 F5 ADCY3 RYR1 RYR2 RYR3 KCNC2 SACS KCNJ8 SCN2A SCN4A SCN9A TAF7 ATP1A4

1.24e-04100816419CID000000813
Drugbimoclomol

RYR1 RYR3 AKAP13

1.26e-04141643CID009576891
DrugAC1L1F95

SYNE1 IL17F TMEM132D

1.26e-04141643CID000003137
Drugarabinosyladenine

GPLD1 CACNA2D1 ATP7B MARS1 SPTA1 GART ABCC9 GRIA3 ITGA2B F5 ADCY3 RYR1 RYR2 RYR3 PI4KB KCNJ8

1.30e-0476216416CID000000191
Drugsipatrigine

CACNA2D1 SCN2A SCN4A SCN9A

1.42e-04371644CID000060803
DrugN-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide

SCN4A SCN9A

1.54e-0431642ctd:C561228
Drug1,1'-diheptyl-4,4'-bipyridinium

RYR1 RYR3

1.54e-0431642CID000080262
Drugflubendiamide

RYR1 RYR3

1.54e-0431642CID011193251
DrugNSC-40277

IL17F TMEM132D

1.54e-0431642CID000237064
DrugGvapspat amide

RYR1 RYR2 RYR3

1.57e-04151643CID000125015
Drugnonanol

GRIA3 SCN2A SCN4A

1.57e-04151643CID000008914
DrugAC1L98DX

STX8 RYR1 RYR2 RYR3

1.58e-04381644CID000439957
Druglidocaine

CACNA2D1 ADCY3 RYR1 RYR2 RYR3 SCN4A SCN9A

1.64e-041601647CID000003676
DrugCID9959010

STX8 RYR1 RYR3 SLC22A18

1.75e-04391644CID009959010
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN2A SCN4A SCN8A SCN9A

1.19e-09101635DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN2A SCN4A SCN8A SCN9A

1.19e-09101635DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN2A SCN4A SCN8A SCN9A

3.71e-09121635DOID:0060170 (implicated_via_orthology)
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR1 RYR2 RYR3

1.65e-0731633DOID:3529 (implicated_via_orthology)
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR1 RYR2 RYR3

1.65e-0731633DOID:8545 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

GAD1 TMTC3 SCN1A SCN2A SCN4A SCN8A SCN9A DEPDC5 ATP1A4

3.32e-071631639DOID:1826 (implicated_via_orthology)
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1A SCN2A SCN9A

1.36e-0591633C3502809
DiseaseTachycardia, Ventricular

ABCC9 RYR2 KCNJ8

2.64e-05111633C0042514
DiseaseShortened QT interval

CACNA2D1 ABCC9 KCNJ8

2.64e-05111633C0151879
DiseaseCantu syndrome

ABCC9 KCNJ8

3.03e-0521632C0795905
DiseaseEarly Infantile Epileptic Encephalopathy 6

SCN1A SCN9A

3.03e-0521632C4551549
Diseasehypertrichotic osteochondrodysplasia Cantu type (implicated_via_orthology)

ABCC9 KCNJ8

3.03e-0521632DOID:0060569 (implicated_via_orthology)
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN2A SCN9A

4.54e-05131633C0751122
Diseasephosphatidylcholine 40:7 measurement

PDXDC1 RAPSN NOMO1

4.54e-05131633EFO_0021477
Diseasephosphatidylcholine 38:6 measurement

RAPSN PTPRA DEPDC5

8.79e-05161633EFO_0010388
DiseaseEarly infantile epileptic encephalopathy with suppression bursts

SCN1A SCN2A DNM1

8.79e-05161633C0393706
Diseaselevel of Phosphatidylcholine (18:0_20:3) in blood serum

PDXDC1 RAPSN NOMO1

8.79e-05161633OBA_2045093
DiseaseB Virus Infection

SCN8A SCN9A

9.07e-0531632C0037140
DiseaseBenign familial infantile epilepsy

SCN2A SCN8A

9.07e-0531632cv:C5575231
DiseasePostherpetic neuralgia

SCN8A SCN9A

9.07e-0531632C0032768
DiseaseHerpesviridae Infections

SCN8A SCN9A

9.07e-0531632C0019372
Disease1-oleoyl-2-dihomo-linolenoyl-GPC (18:1/20:3) measurement

PDXDC1 RAPSN

9.07e-0531632EFO_0800461
Diseaseage at assessment, pelvic organ prolapse

ABCC9 SACS TJP1 TBC1D1

9.36e-05431634EFO_0004710, EFO_0008007
Diseaselevel of Sterol ester (27:1/20:3) in blood serum

PDXDC1 RAPSN NOMO1

1.50e-04191633OBA_2045199
DiseaseBone Marrow failure syndromes

SRP72 ERCC6L2

1.81e-0441632C2931245
DiseaseBone marrow failure syndrome 2

SRP72 ERCC6L2

1.81e-0441632C3810350
Disease1-dihomo-linolenoyl-GPC (20:3n3 or 6) measurement

PDXDC1 RAPSN

1.81e-0441632EFO_0800235
DiseaseBone marrow failure syndrome 1

SRP72 ERCC6L2

1.81e-0441632C3808553
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN2A SCN9A

2.36e-04221633DOID:2030 (implicated_via_orthology)
Diseaseinsulin sensitivity measurement

RAPSN ALDH1L1 ARMC8

2.70e-04231633EFO_0004471
DiseaseLiver Cirrhosis

ATP7B F5 CYP2R1 C1QB TAGLN2

2.74e-041031635C0023890
DiseaseFibrosis, Liver

ATP7B F5 CYP2R1 C1QB TAGLN2

2.99e-041051635C0239946
DiseaseCerebellar Ataxia

SYNE1 SCN8A

3.00e-0451632C0007758
Disease1-palmitoyl-2-dihomo-linolenoyl-GPC (16:0/20:3n3 or 6) measurement

PDXDC1 RAPSN

3.00e-0451632EFO_0800407
DiseaseBrugada Syndrome (disorder)

CACNA2D1 ABCC9 KCNJ8

3.08e-04241633C1142166
DiseaseMalignant neoplasm of breast

ATP7B SYNE1 CD109 OBSCN OR12D3 SLC22A18 FASN CSF1R TLE3 HEATR9 C1QB MACF1 ZFYVE26 BOD1L1 TOP2A DOP1A

3.16e-04107416316C0006142
DiseaseEpilepsy

SCN1A SCN2A SCN8A SCN9A DNM1

3.56e-041091635C0014544
DiseaseMULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE

RAPSN RYR1

4.48e-0461632C1854678
DiseaseEPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1

SCN1A DNM1

4.48e-0461632C3463992
DiseaseLennox-Gastaut syndrome

SCN1A DNM1

4.48e-0461632C0238111
DiseaseNeonatal Alloimmune Thrombocytopenia

CD109 ITGA2B

4.48e-0461632C3853779
DiseaseFNAITP

CD109 ITGA2B

4.48e-0461632C3854603
Diseasedihomo-linolenate 20:3n3 or n6 measurement

PDXDC1 RAPSN

4.48e-0461632EFO_0021046
Disease1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4n6) measurement

PDXDC1 RAPSN

4.48e-0461632EFO_0800390
Disease1-stearoyl-2-dihomo-linolenoyl-GPC (18:0/20:3n3 or 6) measurement

PDXDC1 RAPSN

4.48e-0461632EFO_0800434
DiseaseFamilial benign neonatal epilepsy

SCN2A SCN8A

4.48e-0461632C0220669
DiseaseLissencephaly

TMTC3 MACF1

4.48e-0461632C0266463
Disease1-dihomo-linolenoyl-GPE (20:3n3 or 6) measurement

PDXDC1 RAPSN

4.48e-0461632EFO_0800358
Diseaseneuroblastoma

TMPRSS4 TENM2 ANO7 CEP295 FBXO32

4.74e-041161635EFO_0000621
Diseasecorpus callosum central volume measurement

LNX1 PIGO PDZD2

4.90e-04281633EFO_0010296
Diseaseaortic measurement

ANO1 ABCC9 RYR2 COL18A1 FBXO32 PIPSL LNX1

5.12e-042511637EFO_0020865
DiseaseSeizure, Febrile, Simple

SCN1A SCN2A

6.25e-0471632C0149886
DiseaseSeizure, Febrile, Complex

SCN1A SCN2A

6.25e-0471632C0751057
DiseaseSarcomatoid Renal Cell Carcinoma

PDXDC1 DNHD1 RYR1 AKAP13 TAGLN2

7.41e-041281635C1266043
DiseaseChromophobe Renal Cell Carcinoma

PDXDC1 DNHD1 RYR1 AKAP13 TAGLN2

7.41e-041281635C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

PDXDC1 DNHD1 RYR1 AKAP13 TAGLN2

7.41e-041281635C1266044
DiseasePapillary Renal Cell Carcinoma

PDXDC1 DNHD1 RYR1 AKAP13 TAGLN2

7.41e-041281635C1306837
DiseaseRenal Cell Carcinoma

PDXDC1 DNHD1 RYR1 AKAP13 TAGLN2

7.41e-041281635C0007134
DiseaseEarly Childhood Epilepsy, Myoclonic

SCN1A SCN9A

8.31e-0481632C0393695
DiseaseIdiopathic Myoclonic Epilepsy

SCN1A SCN9A

8.31e-0481632C0338478
DiseaseSymptomatic Myoclonic Epilepsy

SCN1A SCN9A

8.31e-0481632C0338479
DiseaseX-linked infantile spasms

SCN1A DNM1

8.31e-0481632C4552072
DiseaseBenign Infantile Myoclonic Epilepsy

SCN1A SCN9A

8.31e-0481632C0751120
DiseaseMyoclonic Encephalopathy

SCN1A SCN9A

8.31e-0481632C0438414
Diseasefatty acid desaturase enzyme activity measurement

PDXDC1 RAPSN

8.31e-0481632EFO_0009791
DiseaseMyoclonic Absence Epilepsy

SCN1A SCN9A

8.31e-0481632C0393703
Diseasetriacylglycerol 58:10 measurement

RAPSN SCN9A LNX1

8.73e-04341633EFO_0010437
DiseaseIntellectual Disability

UBA5 SYNE1 LETM1 COL18A1 FASN SACS SCN1A SCN8A MACF1

8.91e-044471639C3714756
Diseasetotal iron binding capacity

UBA5 HBS1L RAPSN F5

9.32e-04781634EFO_0006334
Diseaseplatelet component distribution width

HBS1L RAPSN ARMC3 SYNE1 SPTA1 ITGA2B COL18A1 G3BP1 MACF1 AKAP13 TAGLN2 DNM1

1.04e-0375516312EFO_0007984
DiseaseFebrile Convulsions

SCN1A SCN2A

1.06e-0391632C0009952
Diseaselevel of Phosphatidylcholine (O-18:1_20:3) in blood serum

PDXDC1 RAPSN

1.06e-0391632OBA_2045130
DiseaseMyoclonic Epilepsy

SCN1A SCN9A

1.06e-0391632C0014550
Disease1-stearoyl-2-arachidonoyl-GPC (18:0/20:4) measurement

PDXDC1 RAPSN

1.06e-0391632EFO_0800271
DiseaseProfound Mental Retardation

LETM1 COL18A1 FASN SCN1A SCN8A

1.07e-031391635C0020796
DiseaseMental Retardation, Psychosocial

LETM1 COL18A1 FASN SCN1A SCN8A

1.07e-031391635C0025363
DiseaseMental deficiency

LETM1 COL18A1 FASN SCN1A SCN8A

1.07e-031391635C0917816
DiseaseEpilepsy, Cryptogenic

SCN1A SCN2A SCN8A DNM1

1.12e-03821634C0086237
DiseaseAwakening Epilepsy

SCN1A SCN2A SCN8A DNM1

1.12e-03821634C0751111
DiseaseAura

SCN1A SCN2A SCN8A DNM1

1.12e-03821634C0236018
Diseasesystemic scleroderma, rheumatoid arthritis, myositis, systemic lupus erythematosus

IL12RB2 TYK2 TNPO3

1.21e-03381633EFO_0000685, EFO_0000717, EFO_0000783, MONDO_0007915
DiseaseEpilepsy, Myoclonic, Infantile

SCN1A SCN9A

1.33e-03101632C0917800
Diseaselevel of Phosphatidylcholine (16:0_20:3) in blood serum

PDXDC1 RAPSN

1.33e-03101632OBA_2045075
Diseasefat body mass

NR2C1 SMCHD1 TMPRSS4 ADCY3 TMEM132D SCN2A

1.35e-032171636EFO_0005409
DiseaseInherited neuropathies

SACS SCN9A ZFYVE26

1.41e-03401633C0598589
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

PDXDC1 DNHD1 RYR1 AKAP13 TAGLN2

1.42e-031481635C0279702
DiseaseOther specified cardiac arrhythmias

CACNA2D1 KCNJ8

1.61e-03111632C0348626
DiseaseNodal rhythm disorder

CACNA2D1 KCNJ8

1.61e-03111632C0264893
DiseaseEctopic rhythm

CACNA2D1 KCNJ8

1.61e-03111632C1399226
DiseaseParanoia

TYK2 HSD3B2

1.61e-03111632C1456784
Diseaseearly infantile epileptic encephalopathy (implicated_via_orthology)

UBA5 SCN8A

1.61e-03111632DOID:0050709 (implicated_via_orthology)
DiseaseCARDIAC CONDUCTION DEFECT, NONSPECIFIC (disorder)

CACNA2D1 KCNJ8

1.61e-03111632C2748542
DiseaseMyoclonic Astatic Epilepsy

SCN1A SCN9A

1.61e-03111632C0393702
Diseaseheart rate

DAB2IP CACNA2D1 RAPSN TMEM132D TBC1D1 PDZD2

1.62e-032251636EFO_0004326
Diseasebeta-nerve growth factor measurement

F5 FASN TLN2

1.62e-03421633EFO_0008035
Diseasespleen volume

HBS1L SPTA1 TJP1

1.74e-03431633EFO_0600047
DiseaseNeurodevelopmental Disorders

SCN1A SCN2A SCN8A DNM1

1.79e-03931634C1535926
DiseaseColorectal Carcinoma

ATP7B ABCA13 SYNE1 CD109 OBSCN ALDH1L1 F5 GMCL2 SACS PIGO AGTPBP1

1.88e-0370216311C0009402
Diseaselinoleoyl-arachidonoyl-glycerol (18:2/20:4) [2] measurement

RAPSN PDZD2

1.93e-03121632EFO_0800500
Diseaselevel of Phosphatidylinositol (16:0_18:1) in blood serum

PDXDC1 RAPSN

1.93e-03121632OBA_2045152

Protein segments in the cluster

PeptideGeneStartEntry
EGVKNIMTQNVERIL

VAMP8

21

Q9BV40
IMNVNVKGTQLLLEA

HSD3B2

96

P26439
NGILQVDKQKIVEGM

EGFLAM

706

Q63HQ2
SLSQVAMLVVNQGKG

CATSPERD

206

Q86XM0
ALIGKQEGRNIEVMN

COPS6

71

Q7L5N1
EKIVVLGQVLMNESL

ARMH2

56

H3BNL8
SIEGMISQLEGVQQI

ATP7B

376

P35670
EGVGMLVVVAVNNQQ

GOT1L1

256

Q8NHS2
GVMLKLVEQINISQD

FERMT1

41

Q9BQL6
MKSAINEVEILQGLV

AKAP13

2421

Q12802
TGNLVVNLLVGLMEK

ABCA13

1701

Q86UQ4
KSVIQGLFQQGLMGI

ACADSB

91

P45954
QILKQEGGNSELIMD

AKAP11

1351

Q9UKA4
ELLVQAMVGILQVNG

DOP1A

326

Q5JWR5
GEMTLGQINNLVAIE

ABCC9

406

O60706
TMVQIQQTGGLKKLL

ARMC3

266

Q5W041
ENMIQTLTGGLQSVK

DNHD1

576

Q96M86
LLGMATQCVQVKNVV

AGO4

531

Q9HCK5
LSIIMLGKQLIQNNI

ANO2

681

Q9NQ90
VTKGGSQILLQLLMN

AGTPBP1

106

Q9UPW5
VNSVSLGKNGVVELM

AGTPBP1

191

Q9UPW5
LVIGPQQQFLVMKQT

CDC14C

321

A4D256
TGAVQTEAMKQILGV

CAPRIN1

46

Q14444
QLQAMIQAAGKLVLI

CHD7

1281

Q9P2D1
QIGIIGIQNLITRNM

RAD51AP2

541

Q09MP3
MGEIVTEQQTGQKIQ

NR2C1

16

P13056
MIEVQEGQNLKITIT

NOMO3

941

P69849
MTEIGNRLGQVQALL

RAPSN

276

Q13702
GKQLAIQVSNILGMD

RIMKLA

241

Q8IXN7
LGVTQLAVAVNKMDQ

HBS1L

396

Q9Y450
AQELLVIMVGKQVIN

ANO7

641

Q6IWH7
LQTNMANLKVIGIVI

MEIOB

16

Q8N635
GLQKMVIENDLSGLI

DAB2IP

681

Q5VWQ8
ILTKQRMIDNGIGVD

DEPDC5

351

O75140
MIEVQEGQNLKITIT

NOMO2

941

Q5JPE7
LQGQITEGSNMIKTI

KAT7

326

O95251
MGKIENNERVILNVG

KCNC2

1

Q96PR1
LQNIVGLIINAVMLG

KCNJ8

161

Q15842
MGEQLRLVKSQLQGL

LAMA3

1836

Q16787
SIIVLMAGQQLSGIN

SLC2A7

286

Q6PXP3
QGQRTIGVITKLDLM

DNM1

196

Q05193
QVTLQELTGGKAMTQ

IL12RB2

361

Q99665
RVQQMIGQIDGLISQ

LETM1

611

O95202
ILVKEKGILQGCNQM

GAD1

416

Q99259
GIDIERALKMVQVQG

GRIA3

351

P42263
TGIAQVKIQGQNKEM

FLOT1

66

O75955
ELAQQIQKVVMALGD

EIF4A1

111

P60842
EILSLNGQLMVGVDV

PDZD2

141

O15018
LQGSGQDMVSILQLV

PDXDC1

51

Q6P996
LQGSGQDMVSILQLV

PDXDC2P

51

Q6P474
QAMVLLGVKLSGVQD

COL18A1

531

P39060
MIEVQEGQNLKITIT

NOMO1

941

Q15155
GLLVGSEKVTMQNLN

KRT16

111

P08779
EQIVDGKMTNAQIIL

KRT23

131

Q9C075
MKLQQVNGLGQGLIQ

MACF1

1416

O94854
GDIILKVNGMDISNV

LNX1

321

Q8TBB1
IIMLGKQLIQNNLFE

ANO1

666

Q5XXA6
GVMDQVTIINSTLGK

GCAT

251

O75600
VVTGDNVGNVILLNM

DDB2

216

Q92466
KLDIGIINENQRVSM

IL17F

56

Q96PD4
TGGKNIRIVVMNNLL

PIPSL

181

A2A3N6
NLIGNGSILVMVVLE

OR12D3

36

Q9UGF7
VVSQGRQQMLVIKGF

OBSCN

4671

Q5VST9
LVTGNLVQFGVMIEK

PLA2G2E

16

Q9NZK7
NIRQQVLKSGMLESG

BOD1L1

116

Q8NFC6
VLQGVIDMKNAVIGN

ARMC8

36

Q8IUR7
IVGIVAVDKSVNLMN

CD109

586

Q6YHK3
QEVTVGEGLNLKVMV

CSF1R

311

P07333
VNLDGEVIGVNTMKV

HTRA2

311

O43464
QRVMVEQSEKLNGVL

FBH1

586

Q8NFZ0
SGNVNLTLQMKIIEQ

EIF2AK1

586

Q9BQI3
KTNLKNQLILGVMGV

CACNA2D1

476

P54289
NQLILGVMGVDVSLE

CACNA2D1

481

P54289
NIQGQVQKEIDLIMG

CYP2R1

331

Q6VVX0
LNDGVVVQVMGLLSN

G3BP1

86

Q13283
QQIFKMLAEVLGGIN

FASTKD1

701

Q53R41
GVTVAQQQQEELKGM

ADCY3

206

O60266
GMVLKLEQGENVFLQ

C1QB

211

P02746
SLLQGTIQMIQERLG

CEMIP2

321

Q9UHN6
VNLLTIIGNSMGLVN

DNAH14

666

Q0VDD8
ELLTNQVGEKMVVVQ

CUL9

736

Q8IWT3
VLQGVNGEMVLSQLL

HEATR1

1021

Q9H583
MGGNFEIIIKQILQD

CCDC168

1116

Q8NDH2
QILQDKIAAGMLLNV

CCDC168

1126

Q8NDH2
VRIGLTGTILQNNMK

ERCC6L2

306

Q5T890
NTKVSEIQGMLQELI

FAM186A

231

A6NE01
EGMQSTILVLQQQLK

WTAP

216

Q15007
VQRVGKSVLVGNINM

FBXO32

181

Q969P5
AELQKVLQGDLVMNV

FASN

1491

P49327
GTIQQMIGIFKNIIS

CFAP69

506

A5D8W1
KRGVVTMLQSQGLIE

CEP295

2286

Q9C0D2
MGQGQEKVALQLLET

DNAH10

3911

Q8IVF4
EVVKTRMQLQGELQA

SLC25A35

21

Q3KQZ1
LLLFGQGVKTMQVVE

SLC19A3

96

Q9BZV2
AMKANEISVIQNGGI

SALL1

1246

Q9NSC2
KSRIQGNIGVQMLVD

SACS

3931

Q9NZJ4
ISILNGGNAEVQQKM

RYR1

3801

P21817
LEGNVVNGTIGKQMV

RYR2

3986

Q92736
GKGMISIIAAVQKQQ

PTPRA

706

P18433
KEMQVTISQQLGLEL

ONECUT3

441

O60422
GIIVIKDNMAQEGVI

NTMT1

161

Q9BV86
QKLINQSLVMGIEVG

ARHGAP20

896

Q9P2F6
LVRVIDQEMQAIGGQ

PARS2

101

Q7L3T8
NEGTNQLVMGIQKQI

TAF7

271

Q15545
TILKGLQSIFQEQGM

SMS

21

P52788
QGIESQEERQGKMLL

STK40

76

Q8N2I9
VQMGQELQGEVVIII

SMCHD1

1161

A6NHR9
QKLFGMIITIGQAIV

SEC61A2

116

Q9H9S3
LNMLIKIIGNSVGAL

SCN4A

686

P35499
QNMLEGVGVDINKAL

SYCP3

71

Q8IZU3
VMADLGLNERQVIQK

SYNE1

4411

Q8NF91
IAKLQGGQILMGQEL

TMEM132D

621

Q14C87
QLQEGKNVIGLQMGT

TAGLN2

166

P37802
DMQKEVIITGIQTQG

F5

1966

P12259
LVVGIDLKNQMVLLQ

AIFM2

81

Q9BRQ8
IQSTLGAEGKIQMVV

PIWIL2

656

Q8TC59
ELGINVMKQLIGSSN

GMCL2

251

Q8NEA9
ILTVQEMAGLNNKTI

MORC4

511

Q8TE76
TLNMLIKIIGNSVGA

SCN9A

851

Q15858
LMVTNDGATILKNIG

CCT2

61

P78371
GLKVVSTQNLELGLM

TENM2

1666

Q9NT68
VTVAGNLGMIVLIQA

OR5M8

36

Q8NGP6
KNAQIGIAMLVSVGN

ITGA2B

726

P08514
LIGQGQLNQAMKILQ

SRP72

186

O76094
KVVQIVEIMQQGSQL

PI4KB

746

Q9UBF8
LLGQMQLQKGVVAVN

ABCC12

526

Q96J65
MLEGFQILVQNTVQG

SYT14P1

1

Q58G82
LQMVTQGLVIGQLSS

SLC22A18

286

Q96BI1
LNMLIKIIGNSVGAL

SCN1A

876

P35498
AIMGIQGEIQKICQT

ACTN3

581

Q08043
MKIAVIGQSLFGQEV

ALDH1L1

1

O75891
QALVIRGGEKMQINV

ATP1A4

176

Q13733
RGGEKMQINVQEVVL

ATP1A4

181

Q13733
IQRIVGVLQKPQMGE

CIART

161

Q8N365
INKGGIDAVESLMIN

CLHC1

516

Q8NHS4
AKQVTMAELNAIIGQ

TLE1

111

Q04724
GENEQEKKMQIVLQG

ZNF143

206

P52747
ISMPQELQVLVKVNG

ZSCAN5DP

91

P0CG00
GTENIVAVMISNLKG

RNF148

146

Q8N7C7
QKLFGMIITIGQSIV

SEC61A1

116

P61619
LLEGNVVNGTIGKQM

RYR3

3881

Q15413
VVNGTIGKQMVDTLV

RYR3

3886

Q15413
TTMGVVAGILVQNVL

UBA5

256

Q9GZZ9
LKFIQQMAGSVVVQL

TTYH2

171

Q9BSA4
MPQELQVLVKVNGVQ

ZSCAN5B

96

A6NJL1
PNLGLVQMEKTINQV

TBC1D1

1031

Q86TI0
QMLKTIGLEQIQAQG

HEATR9

351

A2RTY3
TLNMLIKIIGNSVGA

SCN2A

866

Q99250
VLMNGTLKQVLLVGA

GPLD1

656

P80108
GGKMSDILLQASVQV

TMPRSS4

336

Q9NRS4
AEIAGLQIGDKIMQV

TAX1BP3

66

O14907
LNMLIKIIGNSVGAL

SCN8A

861

Q9UQD0
DGEMNNLQISVIRIK

SCN8A

991

Q9UQD0
KQLAIQVSNILGMDV

RIMKLB

246

Q9ULI2
IISRQKQMGQEIGNE

STX8

161

Q9UNK0
QLENIQKTGQEMIEG

SPTA1

636

P02549
LQSQVQTVLVRMGGL

TMEM82

261

A0PJX8
LIESMQINGSVLKNG

GART

781

P22102
AKQVTMTELNAIIGQ

TLE3

111

Q04726
MLVAEQAVGAGQLQV

nan

106

Q96MT0
ELRKELIGQVMNQLG

TNPO3

816

Q9Y5L0
GDVVLKINGTVTENM

TJP1

226

Q07157
IMENAEINNIIKIVG

TOP2A

501

P11388
GQITVKIMDNGIQGE

ZDHHC5

276

Q9C0B5
TIDQILEMVNGQRGL

TTC28

1221

Q96AY4
GGIAQIIAAQEEMLK

TLN2

2496

Q9Y4G6
DIEGILQKFTGNIMQ

TRUB1

181

Q8WWH5
KLSQMDQVIQGLVER

PIGO

251

Q8TEQ8
MANINLKEITLIVGV

TMTC3

1

Q6ZXV5
LQQLLVGQEIGFTMD

ZFYVE26

1701

Q68DK2
QIQALMDEVTKQGNI

MARS1

841

P56192
QVVQGMKEAQERLTG

TXNDC12

146

O95881
TKFLELIGIAQGQMT

TYK2

1106

P29597
IQKEVMNGAILQQVF

NMD3

116

Q96D46