Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 OR6N1 OR10G7 OR10G4

1.36e-224318926GO:0004984
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR5T1 OR5B3 OR8D1 GPR17 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 GPR132 OR6N1 OR10G7 OR10G4

6.59e-178848928GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR5T1 OR5B3 OR8D1 GPR17 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 GRIK4 OR2M3 OR10G9 OR6C6 OR10S1 GPR132 ALK OR6N1 OR10G7 OR10G4

5.63e-1413538930GO:0004888
GeneOntologyMolecularFunctionodorant binding

OR5T1 OR5B3 OR8D1 OR8D2 OR6N2 OR5B2 OR9Q2 OR9Q1 OR5B17

5.30e-09127899GO:0005549
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC37A1 SLC9A1 SLC15A1 SLC15A2 SLC6A17 SLC22A5 SLC7A11 SLC38A3

5.30e-05296898GO:0015291
GeneOntologyMolecularFunctionpeptide:proton symporter activity

SLC15A1 SLC15A2

1.17e-044892GO:0015333
GeneOntologyMolecularFunctiondipeptide transmembrane transporter activity

SLC15A1 SLC15A2

1.95e-045892GO:0071916
GeneOntologyMolecularFunctionsymporter activity

SLC15A1 SLC15A2 SLC6A17 SLC22A5 SLC38A3

5.59e-04150895GO:0015293
GeneOntologyMolecularFunctiontripeptide transmembrane transporter activity

SLC15A1 SLC15A2

6.93e-049892GO:0042937
GeneOntologyMolecularFunctionpeptide transmembrane transporter activity

SLC15A1 SLC15A2

6.93e-049892GO:1904680
GeneOntologyMolecularFunctionamide transmembrane transporter activity

SLC15A1 SLC15A2 SLC38A3

8.67e-0442893GO:0042887
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC37A1 SLC9A1 SLC15A1 SLC15A2 SLC6A17 SLC22A5 SLC7A11 SLC38A3

1.30e-03477898GO:0022804
GeneOntologyMolecularFunctionproton transmembrane transporter activity

SLC9A1 SLC15A1 SLC15A2 OTOP2 SLC38A3

1.54e-03188895GO:0015078
GeneOntologyBiologicalProcesssensory perception of smell

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 ADCY3 OR6N1 OR10G7 OR10G4

2.14e-234658927GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 OR6N1 OR10G7 OR10G4

6.48e-234328926GO:0050911
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 OR6N1 OR10G7 OR10G4

1.22e-214858926GO:0050907
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 ADCY3 OR6N1 OR10G7 OR10G4

1.51e-215478927GO:0007606
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 OR6N1 OR10G7 OR10G4

8.53e-215248926GO:0009593
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 OR6N1 OR10G7 OR10G4

1.17e-195828926GO:0050906
GeneOntologyBiologicalProcessdetection of stimulus

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 OR6N1 OR10G7 OR10G4

2.32e-177228926GO:0051606
GeneOntologyBiologicalProcesssensory perception

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 ADCY3 OR6N1 OR10G7 OR10G4

3.34e-1410728927GO:0007600
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR5T1 OR5B3 OR8D1 GPR17 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 GPR132 ADCY3 ALK OR6N1 OR10G7 OR10G4

5.40e-1413958930GO:0007186
GeneOntologyBiologicalProcessoligopeptide import across plasma membrane

SLC15A1 SLC15A2 SLC7A11

7.72e-075893GO:0140205
GeneOntologyBiologicalProcessdipeptide import across plasma membrane

SLC15A1 SLC15A2 SLC7A11

7.72e-075893GO:0140206
GeneOntologyBiologicalProcessdipeptide transport

SLC15A1 SLC15A2 SLC7A11

4.28e-068893GO:0042938
GeneOntologyBiologicalProcessdipeptide transmembrane transport

SLC15A1 SLC15A2 SLC7A11

4.28e-068893GO:0035442
GeneOntologyBiologicalProcesstripeptide transmembrane transport

SLC15A1 SLC15A2 SLC7A11

9.12e-0610893GO:0035443
GeneOntologyBiologicalProcesstripeptide import across plasma membrane

SLC15A1 SLC15A2

1.84e-052892GO:0140207
GeneOntologyBiologicalProcesstripeptide transport

SLC15A1 SLC15A2 SLC7A11

2.15e-0513893GO:0042939
GeneOntologyBiologicalProcessoligopeptide transmembrane transport

SLC15A1 SLC15A2 SLC7A11

5.05e-0517893GO:0035672
GeneOntologyBiologicalProcessnegative regulation of phospholipase A2 activity

ANXA8L1 ANXA8

5.51e-053892GO:1900138
GeneOntologyBiologicalProcessoligopeptide transport

SLC15A1 SLC15A2 SLC7A11

1.29e-0423893GO:0006857
GeneOntologyBiologicalProcessneutral amino acid transport

ACE2 SLC6A17 SLC7A11 SLC38A3

1.31e-0460894GO:0015804
GeneOntologyBiologicalProcessnegative regulation of phospholipase activity

ANXA8L1 ANXA8

1.83e-045892GO:0010519
GeneOntologyBiologicalProcessimport across plasma membrane

ACE2 SLC9A1 SLC15A1 SLC15A2 SLC7A11 SLC38A3

4.84e-04230896GO:0098739
GeneOntologyBiologicalProcessnegative regulation of serine-type peptidase activity

ANXA8L1 ANXA8

5.07e-048892GO:1902572
GeneOntologyBiologicalProcessnegative regulation of serine-type endopeptidase activity

ANXA8L1 ANXA8

5.07e-048892GO:1900004
GeneOntologyBiologicalProcesstransport across blood-brain barrier

SLC15A2 SLC6A17 SLC22A5 SLC38A3

5.49e-0487894GO:0150104
GeneOntologyBiologicalProcessvascular transport

SLC15A2 SLC6A17 SLC22A5 SLC38A3

5.73e-0488894GO:0010232
GeneOntologyBiologicalProcessexport across plasma membrane

SLC9A1 SLC15A2 SLC22A5 KCNE5

6.50e-0491894GO:0140115
GeneOntologyBiologicalProcessregulation of serine-type peptidase activity

ANXA8L1 ANXA8

8.10e-0410892GO:1902571
GeneOntologyBiologicalProcessregulation of phospholipase A2 activity

ANXA8L1 ANXA8

8.10e-0410892GO:0032429
GeneOntologyBiologicalProcessintracellular amino acid homeostasis

SLC7A11 SLC38A3

8.10e-0410892GO:0080144
GeneOntologyBiologicalProcessregulation of serine-type endopeptidase activity

ANXA8L1 ANXA8

8.10e-0410892GO:1900003
GeneOntologyCellularComponentautophagosome

TM9SF1 RAB2B VPS16 RAB2A WIPI2

1.73e-04119915GO:0005776
DomainOlfact_rcpt

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 OR6N1 OR10G7 OR10G4

9.36e-233939026IPR000725
DomainGPCR_Rhodpsn_7TM

OR5T1 OR5B3 OR8D1 GPR17 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 GPR132 OR6N1 OR10G7 OR10G4

3.74e-196709028IPR017452
Domain7tm_1

OR5T1 OR5B3 OR8D1 GPR17 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 GPR132 OR6N1 OR10G7 OR10G4

4.92e-196779028PF00001
DomainG_PROTEIN_RECEP_F1_1

OR5T1 OR5B3 OR8D1 GPR17 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 GPR132 OR6N1 OR10G7 OR10G4

6.71e-196859028PS00237
DomainG_PROTEIN_RECEP_F1_2

OR5T1 OR5B3 OR8D1 GPR17 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 GPR132 OR6N1 OR10G7 OR10G4

8.43e-196919028PS50262
DomainGPCR_Rhodpsn

OR5T1 OR5B3 OR8D1 GPR17 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 GPR132 OR6N1 OR10G7 OR10G4

8.76e-196929028IPR000276
DomainAnnexinVIII

ANXA8L1 ANXA8

2.30e-052902IPR009115
DomainOligopep_transport

SLC15A1 SLC15A2

2.30e-052902IPR004768
DomainPTR2_symporter_CS

SLC15A1 SLC15A2

6.87e-053902IPR018456
DomainRFX1_trans_act

RFX2 RFX3

6.87e-053902IPR007668
DomainPTR2_1

SLC15A1 SLC15A2

6.87e-053902PS01022
DomainRFX1_trans_act

RFX2 RFX3

6.87e-053902PF04589
DomainPTR2_2

SLC15A1 SLC15A2

1.37e-044902PS01023
DomainPOT_fam

SLC15A1 SLC15A2

2.27e-045902IPR000109
DomainPTR2

SLC15A1 SLC15A2

2.27e-045902PF00854
DomainRAB

RAB2B RAB3D RAB2A RAB13

4.26e-0473904PS51419
DomainRFX_DNA_binding

RFX2 RFX3

8.09e-049902PF02257
DomainDNA-bd_RFX

RFX2 RFX3

8.09e-049902IPR003150
DomainRFX_DBD

RFX2 RFX3

8.09e-049902PS51526
DomainANX

ANXA8L1 ANXA8

1.73e-0313902SM00335
DomainANNEXIN

ANXA8L1 ANXA8

1.73e-0313902PS00223
DomainAnnexin_repeat_CS

ANXA8L1 ANXA8

1.73e-0313902IPR018252
DomainAnnexin

ANXA8L1 ANXA8

1.73e-0313902PF00191
DomainAnnexin_repeat

ANXA8L1 ANXA8

1.73e-0313902IPR018502
Domain-

ANXA8L1 ANXA8

1.73e-03139021.10.220.10
DomainAnnexin

ANXA8L1 ANXA8

2.01e-0314902IPR001464
DomainAa_trans

TMEM104 SLC38A3

2.98e-0317902PF01490
DomainAA_transpt_TM

TMEM104 SLC38A3

2.98e-0317902IPR013057
DomainMFS_dom

SLC37A1 SLC15A1 SLC15A2 SLC22A5

4.02e-03134904IPR020846
DomainRas

RAB2B RAB3D RAB2A RAB13

4.24e-03136904PF00071
DomainSmall_GTPase

RAB2B RAB3D RAB2A RAB13

7.49e-03160904IPR001806
DomainSmall_GTP-bd_dom

RAB2B RAB3D RAB2A RAB13

8.68e-03167904IPR005225
DomainSNF2_N

SMARCA4 CHD1L

1.04e-0232902IPR000330
DomainSNF2_N

SMARCA4 CHD1L

1.04e-0232902PF00176
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 ADCY3 OR6N1 OR10G7 OR10G4

5.63e-224177927M4072
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 ADCY3 OR6N1 OR10G7 OR10G4

5.32e-193897924M14091
PathwayREACTOME_SENSORY_PERCEPTION

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR6C1 OR9Q2 OR9Q1 OR5B17 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 ADCY3 OR6N1 OR10G7 OR10G4

3.02e-176367927M41834
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR8D1 OR10G3 OR2T1 OR10G9 OR10S1 OR10G7 OR10G4

1.20e-0770797MM14984
PathwayREACTOME_SENSORY_PERCEPTION

OR8D1 OR10G3 OR2T1 OR10G9 OR10S1 OR10G7 OR10G4

9.25e-05190797MM15687
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC9A1 SLC15A1 SLC15A2 SLC7A11 SLC38A3

3.45e-04108795M823
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC9A1 SLC15A1 SLC15A2 SLC7A11 SLC38A3

3.61e-04109795MM15074
PathwayREACTOME_RAB_GERANYLGERANYLATION

RAB2B RAB3D RAB2A RAB13

4.77e-0465794M27771
PathwayREACTOME_RAB_GERANYLGERANYLATION

RAB2B RAB3D RAB2A RAB13

4.77e-0465794MM15511
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C1 OR9Q2 OR9Q1 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 OR6N1 OR10G7 OR10G4

3.24e-26340912311875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C1 OR9Q2 OR9Q1 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 OR6N1 OR10G7 OR10G4

3.24e-26340912311802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C1 OR9Q2 OR9Q1 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 OR6N1 OR10G7 OR10G4

3.97e-26343912332295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR5T1 OR5B3 OR8D1 OR8D2 OR2T6 OR2M2 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C1 OR9Q2 OR9Q1 OR2T1 OR2M3 OR10G9 OR6C6 OR10S1 OR6N1 OR10G7 OR10G4

4.86e-26346912314611657
Pubmed

The human olfactory receptor gene family.

OR5T1 OR5B3 OR8D1 OR8D2 OR2T27 OR6N2 OR10G3 OR10G2 OR2AP1 OR2T35 OR5B2 OR6C4 OR5B17 OR2T1 OR2M3 OR10G9 OR10S1 OR6N1 OR10G7 OR10G4

1.14e-17541912014983052
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR2T6 OR2M2 OR10G3 OR5B2 OR6C1 OR9Q1 OR2T1 OR2M3 OR10S1 OR6N1

3.29e-10219911012213199
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

GPD2 USP34 SLC9A1 YIF1B DPY19L2 TMEM168 TM9SF1 SLC22A5 MIPEP RAB3D HACD2 VPS16 ELOVL6 RAB2A RAB13 DEGS1

1.54e-081061911633845483
Pubmed

Molecular cloning and characterization of a novel human Rab ( Rab2B) gene.

RAB2B RAB2A

6.77e-06291212376746
Pubmed

TaqI polymorphisms at the annexin VIII locus (ANX8).

ANXA8L1 ANXA8

6.77e-0629121364010
Pubmed

Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63.

ANXA8L1 ANXA8

6.77e-06291224769558
Pubmed

Importance of a small N-terminal region in mammalian peptide transporters for substrate affinity and function.

SLC15A1 SLC15A2

6.77e-06291211944083
Pubmed

Comparison of human and monkey peptide transporters: PEPT1 and PEPT2.

SLC15A1 SLC15A2

6.77e-06291215981923
Pubmed

Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes.

ANXA8L1 ANXA8

6.77e-06291229306076
Pubmed

Peptide transporters and their roles in physiological processes and drug disposition.

SLC15A1 SLC15A2

6.77e-06291218668438
Pubmed

Lack of interaction between the peptidomimetic substrates captopril and cephradine.

SLC15A1 SLC15A2

6.77e-06291219246733
Pubmed

Bone matrix regulates osteoclast differentiation and annexin A8 gene expression.

ANXA8L1 ANXA8

6.77e-06291221344395
Pubmed

Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited.

SLC15A1 SLC15A2

6.77e-06291218713951
Pubmed

Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2.

SLC15A1 SLC15A2

6.77e-06291218367661
Pubmed

Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer.

ANXA8L1 ANXA8

6.77e-06291216203777
Pubmed

Tissue distribution and thyroid hormone regulation of Pept1 and Pept2 mRNA in rodents.

SLC15A1 SLC15A2

6.77e-06291216202478
Pubmed

Annexins: linking Ca2+ signalling to membrane dynamics.

ANXA8L1 ANXA8

6.77e-06291215928709
Pubmed

Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy.

RAB2B RAB2A

6.77e-06291228063257
Pubmed

The bioactive dipeptide anserine is transported by human proton-coupled peptide transporters.

SLC15A1 SLC15A2

6.77e-06291220067523
Pubmed

Annexins: from structure to function.

ANXA8L1 ANXA8

6.77e-06291211917092
Pubmed

Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.

ANXA8L1 ANXA8

6.77e-06291225803307
Pubmed

Screening of the interaction between xenobiotic transporters and PDZ proteins.

SLC15A1 SLC15A2 SLC22A5

7.71e-061591315553237
Pubmed

Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.

RFX2 RFX3

2.03e-05391215024578
Pubmed

Specific expression of annexin A8 in adult murine stratified epithelia.

ANXA8L1 ANXA8

2.03e-05391217082908
Pubmed

Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.

RFX2 RFX3

2.03e-05391210330134
Pubmed

Ciliogenic RFX transcription factors regulate FGF1 gene promoter.

RFX2 RFX3

2.03e-05391222415835
Pubmed

PDZK1 regulates two intestinal solute carriers (Slc15a1 and Slc22a5) in mice.

SLC15A1 SLC22A5

2.03e-05391218322073
Pubmed

Alternate expression of PEPT1 and PEPT2 in epidermal differentiation is required for NOD2 immune responses by bacteria-derived muramyl dipeptide.

SLC15A1 SLC15A2

2.03e-05391231757425
Pubmed

Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1.

SLC15A1 SLC15A2

2.03e-05391225531100
Pubmed

Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.

RFX2 RFX3

2.03e-05391212403718
Pubmed

Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-fractalkine signaling pathway.

ACE2 CCN2

2.03e-05391224161906
Pubmed

RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.

RFX2 RFX3

2.03e-0539128289803
Pubmed

Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.

RFX2 RFX3

2.03e-05391232725242
Pubmed

Effect of Janus kinase 3 on the peptide transporters PEPT1 and PEPT2.

SLC15A1 SLC15A2

2.03e-05391223934551
Pubmed

Expression profile and functional activity of peptide transporters in prostate cancer cells.

SLC15A1 SLC15A2

2.03e-05391222950754
Pubmed

Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha.

ANXA8L1 ANXA8

2.03e-0539122530088
Pubmed

Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.

RAB2B RAB3D RAB2A RAB13

2.04e-056191412578829
Pubmed

Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.

OR6C4 OR6C1 OR6C6

3.37e-052491324152035
Pubmed

Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.

RAB2B RAB3D RAB2A RAB13

3.94e-057291416923123
Pubmed

Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.

RFX2 RFX3

4.05e-05491211682486
Pubmed

Differential expression of Rfx1-4 during mouse spermatogenesis.

RFX2 RFX3

4.05e-05491219596083
Pubmed

FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice.

RAB2B RAB2A

4.05e-05491234714330
Pubmed

Pathological Ace2-to-Ace enzyme switch in the stressed heart is transcriptionally controlled by the endothelial Brg1-FoxM1 complex.

ACE2 SMARCA4

4.05e-05491227601681
Pubmed

Proton-coupled oligopeptide transporter (POT) family expression in human nasal epithelium and their drug transport potential.

SLC15A1 SLC15A2

4.05e-05491221366347
Pubmed

High-throughput microarray detection of olfactory receptor gene expression in the mouse.

OR2M2 OR2M3

4.05e-05491215377787
Pubmed

The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology.

SLC15A1 SLC15A2

4.05e-05491212905028
Pubmed

Local and cis effects of the H element on expression of odorant receptor genes in mouse.

OR10G3 OR10G2

6.74e-05591217662950
Pubmed

RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow.

RFX2 RFX3

1.41e-04791222233545
Pubmed

The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy.

SLC15A1 SLC15A2

1.41e-04791227553280
Pubmed

Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology.

RAB2B RAB2A

1.41e-04791226209634
Pubmed

The genetic origin of mouse annexin VIII.

ANXA8L1 ANXA8

1.41e-0479129434938
Pubmed

Blood-Brain Barrier: From Physiology to Disease and Back.

SLC15A2 SLC6A17 SLC22A5 SLC38A3

1.71e-0410591430280653
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

SLC9A1 SLC22A5 TMEM115 EI24 MAGOHB RAB3D RAB2A SLC38A3 RAB13 DEGS1

1.96e-04952911038569033
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

USP34 TM9SF1 ANXA8L1 GIGYF1 PEX11B CNOT2 DEGS1

2.02e-0445791732344865
Pubmed

Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.

SLC9A1 LZTR1 TMEM115 EI24 PEX11B SLC7A11 RAB13

2.31e-0446791730194290
Pubmed

RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.

RAB2B RAB2A

2.41e-04991221808068
Pubmed

Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.

OR2T27 OR2T35 OR2M3

2.42e-044691332126975
Pubmed

The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.

ACE2 SLC22A5 GRIK4 SLC7A11 GPR132

2.44e-0421291519521566
Pubmed

Characterization of a cluster comprising approximately 100 odorant receptor genes in mouse.

OR8D1 OR8D2

3.01e-041091211130974
Pubmed

Expression of olfactory receptors in the cribriform mesenchyme during prenatal development.

OR6C1 ADCY3

3.01e-041091215261832
Pubmed

G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.

RFX2 RFX3

3.67e-041191218218630
Pubmed

Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones.

OR10G3 OR10G2

4.39e-04129129110172
Pubmed

Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport.

RAB2B RAB3D RAB2A

4.82e-045891311856727
Pubmed

The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.

RAB2B RAB3D RAB2A

5.86e-046291311773082
Pubmed

Cytoplasmic control of Rab family small GTPases through BAG6.

RAB2B RAB13

6.95e-041591230804014
Pubmed

The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium.

TMEM115 SLC38A3

6.95e-041591211085536
Pubmed

New GPCRs from a human lingual cDNA library.

OR8D1 OR8D2

8.98e-041791211705801
Pubmed

Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis.

RFX2 RFX3

8.98e-041791231068677
Pubmed

PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination.

RAB2A RAB13

8.98e-041791236719382
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR8D2 OR10G3 OR2T35

9.82e-047491315081110
Pubmed

Proteomics characterization of abundant Golgi membrane proteins.

RAB2A RAB13

1.12e-031991211042173
Pubmed

Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.

LZTR1 EI24 SMARCA4 CSTF3 VPS16 WIPI2

1.25e-0345491633226137
Pubmed

Rfx6 directs islet formation and insulin production in mice and humans.

RFX2 RFX3

1.38e-032191220148032
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

GPD2 USP34 YIF1B TM9SF1 SMARCA4 HACD2 PEX11B RAB2A DNAH6 DNAJC3 DEGS1

1.43e-031451911130550785
Pubmed

The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.

RFX2 RFX3

1.51e-032291219887680
Pubmed

Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability.

ANXA8L1 ANXA8

1.51e-032291215733672
Pubmed

Proximity labeling reveals dynamic changes in the SQSTM1 protein network.

TUT4 RAB2B ASCC3 RAB2A RAB13

1.60e-0332291539098523
Pubmed

Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis.

RAB3D RAB13

1.65e-032391220360680
Pubmed

Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation.

SMARCA4 CCN2

1.80e-032491237543677
Pubmed

Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.

OR8D1 OR2T1

1.80e-03249129119360
Pubmed

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.

GPD2 YIF1B TM9SF1 TMEM115 EI24 SLC7A11

2.02e-0349991622810586
Pubmed

Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.

ELOVL6 DEGS1

2.28e-032791225269881
Pubmed

Control of TurboID-dependent biotinylation intensity in proximity ligation screens.

RAB2B SLC7A11 DNAJC3

2.33e-0310091336966971
Pubmed

FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.

SMARCA4 CSTF3 VPS16 ASCC3

2.37e-0321291433462405
Pubmed

Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease.

ANXA8L1 ANXA8

2.45e-032891233953184
Cytoband1q44

OR2T6 OR2M2 OR2T27 OR2T35 OR2T1 OR2M3

9.31e-081109161q44
CytobandEnsembl 112 genes in cytogenetic band chr11q24

OR8D1 OR8D2 EI24 OR10G9 OR10S1 OR10G7 OR10G4

1.16e-07191917chr11q24
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2T6 OR2M2 OR2T27 OR2T35 OR2T1 OR2M3

2.29e-07128916chr1q44
Cytoband11q12.1

OR5T1 OR5B3 OR5B2 OR9Q2 OR9Q1 OR5B17

8.83e-0716191611q12.1
Cytoband12q13.2

OR2AP1 OR6C4 OR6C1 OR6C6

4.56e-065591412q13.2
Cytoband11q24.1

OR10G9 OR10S1 OR10G4

5.57e-053791311q24.1
CytobandEnsembl 112 genes in cytogenetic band chr11q12

OR5T1 OR5B3 OR5B2 OR9Q2 OR9Q1 OR5B17

6.72e-05345916chr11q12
Cytoband11q24.2

OR8D1 OR8D2 OR10G7

2.74e-046391311q24.2
Cytoband14q11.2

OR10G3 OR10G2 TM9SF1 RAB2B

4.68e-0418091414q11.2
Cytoband10q11.22

ANXA8L1 ANXA8

3.03e-034191210q11.22
Cytoband1q23.1

OR6N2 OR6N1

3.80e-03469121q23.1
GeneFamilyOlfactory receptors, family 10

OR10G3 OR10G2 OR10G9 OR10S1 OR10G7 OR10G4

2.05e-0766706157
GeneFamilyOlfactory receptors, family 2

OR2T6 OR2M2 OR2T27 OR2AP1 OR2T35 OR2T1 OR2M3

2.68e-07113707149
GeneFamilyOlfactory receptors, family 6

OR6N2 OR6C4 OR6C1 OR6C6 OR6N1

1.54e-0651705153
GeneFamilyRAB, member RAS oncogene GTPases

RAB2B RAB3D RAB2A RAB13

1.17e-0465704388
GeneFamilySolute carriers

SLC37A1 SLC9A1 SLC15A1 SLC15A2 SLC6A17 SLC22A5 SLC7A11 SLC38A3

1.40e-04395708752
GeneFamilyRegulatory factor X family

RFX2 RFX3

4.08e-0487021153
GeneFamilyOlfactory receptors, family 5

OR5T1 OR5B3 OR5B2 OR5B17

9.34e-04112704152
GeneFamilyAnnexins|Endogenous ligands

ANXA8L1 ANXA8

1.12e-0313702404
GeneFamilyOlfactory receptors, family 9

OR9Q2 OR9Q1

3.55e-0323702156
DrugD1-G

SLC15A1 SLC15A2 SLC22A5

8.70e-0611873CID011171679
Drugglycylsarcosine

SLC9A1 SLC15A1 SLC15A2 SLC22A5

9.51e-0635874CID000093131
DrugZidovudine, AZT [30516-87-1]; Down 200; 15uM; HL60; HG-U133A

SLC9A1 SLC15A2 TMEM115 SMARCA4 CSTF3 DNAJC3 ADCY3

1.10e-051988771595_DN
Drugmoexipril

SLC15A1 SLC15A2

1.44e-052872ctd:C058302
Drugglycylsarcosine

SLC15A1 SLC15A2

1.44e-052872ctd:C004194
Drugquinaprilat

SLC15A1 SLC15A2

1.44e-052872ctd:C054501
Diseasepalmitoyl dihydrosphingomyelin (d18:0/16:0) measurement

SMARCA4 DEGS1

1.63e-047832EFO_0800400
Diseaseprimary biliary cholangitis (biomarker_via_orthology)

ACE2 CCN2

2.82e-0328832DOID:12236 (biomarker_via_orthology)
DiseaseMyocardial Failure

SLC9A1 CCN2 ELOVL6

3.73e-03110833C1959583
DiseaseCongestive heart failure

SLC9A1 CCN2 ELOVL6

3.73e-03110833C0018802
DiseaseHeart failure

SLC9A1 CCN2 ELOVL6

3.73e-03110833C0018801
DiseaseLeft-Sided Heart Failure

SLC9A1 CCN2 ELOVL6

3.73e-03110833C0023212

Protein segments in the cluster

PeptideGeneStartEntry
YADFGPLNLAMVYRY

CDC14B

86

O60729
TSYLYLSMAFYFNRD

FTHL17

31

Q9BXU8
GFLFYLNMYASIYFL

GPR17

136

Q13304
AFLTCLYLAYSYMGN

CDK5R2

261

Q13319
YIAYYRRATVFLAMG

DNAJC3

71

Q13217
AYYRGAMGIILVYDI

RAB13

76

P51153
MAYAYLFKYIIIGDT

RAB2A

1

P61019
YLLAAMSYDRYVAIC

OR6C1

111

Q96RD1
MTYAYLFKYIIIGDT

RAB2B

1

Q8WUD1
YYRGAMGFLLMYDIA

RAB3D

91

O95716
EGYLLTAMAYDRYVA

OR8D1

111

Q8WZ84
SYFAERLYYAMKGAG

ANXA8

256

P13928
DCYLLAIMAYDRYTA

OR9Q2

111

Q8NGE9
ECYLLTAMAYDRYLA

OR6N1

111

Q8NGY5
CFLYTVMSYDRYLAI

OR10G7

111

Q8NGN6
CFLYTVMAYDRYLAI

OR10S1

126

Q8NGN2
CFLYTVMSYDRYLAI

OR10G4

111

Q8NGN3
EFFLLGLMAYDRYVA

OR2T1

161

O43869
DCYLLALMAYDRYLA

OR9Q1

111

Q8NGQ5
EGYLLTAMEYDRYVA

OR8D2

111

Q9GZM6
QLETARKFLYYEMGY

GPD2

591

P43304
SRQAFESMLRYIYYG

LZTR1

716

Q8N653
LADYRYGREEMLALY

GIGYF1

36

O75420
GDDAYLYILLIMIFY

KCNE5

56

Q9UJ90
YYGAALFMYIRPTSD

OR2M2

251

Q96R28
YYGAALFMYIRPTSD

OR2M3

251

Q8NG83
EFFLLGLMAYDRYVA

OR2T6

111

Q8NHC8
YLLASMAYDRYAAVC

OR5B2

111

Q96R09
YLLASMAYDRYAAVC

OR5B3

111

Q8NH48
LLYFAYADYEESRMK

CSTF3

341

Q12996
FYRGMSLEYYGIEAD

DUSP13

91

Q9UII6
YYMLLLTYSGFFCIT

KNTC1

151

P50748
EFFLLGLMSYDRYVA

OR2T27

111

Q8NH04
TQCFLYTLMAYDRYL

OR10G3

111

Q8NGC4
YLLAAMSYDRYVAIC

OR2AP1

111

Q8NGE2
EFFLLGLMAYDRYVA

OR2T35

111

Q8NGX2
FRTEMGLYYSYFKTI

DPY19L2

146

Q6NUT2
YLLASMSYDRYVAIC

OR6C4

111

Q8NGE1
LFYLPVYRDYIMSFG

MOGAT3

151

Q86VF5
LLMGAALGQYAISYY

OTOP2

371

Q7RTS6
MYYFLGVLSFLDVCY

OR5T1

71

Q8NG75
ECYLLTAMAYDRYLA

OR6N2

111

Q8NGY6
ALDYSFLCAYAVGMY

SLC37A1

101

P57057
VMYSYYALRAAGFRV

ELOVL6

176

Q9H5J4
RMALSQYTYGYEYLG

DNAH6

1426

Q9C0G6
SYFAERLYYAMKGAG

ANXA8L1

256

Q5VT79
GDNDIFESLYYRKMY

CCN2

331

P29279
LMLIDFEYSSYNYRG

CHKA

326

P35790
LHMSLLYSLYCFEYR

EI24

206

O14681
SFDYYAFLILIMISY

HACD2

211

Q6Y1H2
LDILQDYMDYRGYSY

CHD1L

376

Q86WJ1
YYFLGIKSLVYMLAA

DEGS1

201

O15121
YLFRSSVAYAMRQYF

ACE2

641

Q9BYF1
FLYLCAIAVGIMSYY

ADCY3

231

O60266
LSGIYRYIMGRFAFY

FOXS1

41

O43638
RYVLYMVNFDGYSAC

EFNA5

76

P52803
LYAGLDYYSLVARFM

GADL1

121

Q6ZQY3
AAELGMVSAYYTYIF

GRIK4

231

Q16099
YYLFSLIMNLSRDAY

PEX11B

126

O96011
ERFSYYGMRAILILY

SLC15A1

26

P46059
ERFSYYGMKAVLILY

SLC15A2

56

Q16348
FGYMVLPLFAYFIRD

SLC22A5

241

O76082
CFLYTVMSYDRYLAI

OR10G9

111

Q8NGN4
QCFLYTLMAYDRYLA

OR10G2

116

Q8NGC3
YLLSSMAYDRYAAVC

OR5B17

111

Q8NGF7
QMDSRIAGYYYARFT

GPR132

191

Q9UNW8
MAVASDFYLRYYVGH

MAGOHB

1

Q96A72
KYSNLYMYVGLFLSL

SERTM2

31

A0A1B0GWG4
IMYFLAALFGYLTFY

SLC38A3

331

Q99624
GSFHLIRLLYDEYMF

RFX2

636

P48378
GSFHLIRLLYDEYMF

RFX3

621

P48380
IMEDYFAYRGFKYLR

SMARCA4

1111

P51532
LVGAADGYLYMYNLD

WIPI2

346

Q9Y4P8
IYYSYGDFLLGKLMD

NOP2

276

P46087
YLLAAMSYDRYVAIC

OR6C6

111

A6NF89
FGMARDIYRASYYRK

ALK

1271

Q9UM73
IPGRYIYTLYFMSDC

ASCC3

2151

Q8N3C0
IYTLYFMSDCYLGLD

ASCC3

2156

Q8N3C0
LGRYGEDLLFYLYYM

CNOT2

436

Q9NZN8
SITRLPLAFYYGMYA

SLC7A11

231

Q9UPY5
YYFAVDTMYVGRKLG

YIF1B

111

Q5BJH7
VGYGARYYSYLMSRA

MIPEP

626

Q99797
SYDFYRYNFSMPSRL

TBX22

471

Q9Y458
AYLLTYMASFNLVYL

TMEM115

116

Q12893
LGDSAFYRKYELYSM

VPS16

11

Q9H269
LYSSYVGLVYMFNLI

TMEM104

11

Q8NE00
PLFVFLYSYMAYLSA

SLC9A1

331

P19634
LYSYMAYLSAELFHL

SLC9A1

336

P19634
GIASILYYYFSMEAA

TMEM168

76

Q9H0V1
YLLATGFMLLFYQYL

XKR3

386

Q5GH77
LTEMLGFRPYRFYFY

SLC6A17

556

Q9H1V8
DDVYDRMLLDYFFSY

USP34

3131

Q70CQ2
RGSLSSYAYILMVLY

TUT4

1116

Q5TAX3
IFLYSVFYYARRSNM

TM9SF1

546

O15321