Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	CCDC88C ARHGEF28 GOPC TRIO MYO9A RAPGEF3 RALBP1 NUCB1 LRRK2 OBSCN	7.81e-05	507	88	10	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	CCDC88C ARHGEF28 GOPC TRIO MYO9A RAPGEF3 RALBP1 NUCB1 LRRK2 OBSCN	7.81e-05	507	88	10	GO:0030695
GeneOntologyBiologicalProcess	positive regulation of RIG-I signaling pathway	DDX60 PUM2 PUM1	1.21e-05	11	88	3	GO:1900246
GeneOntologyBiologicalProcess	centrosome localization	AKAP9 SYNE1 CEP83 CCDC141	1.46e-05	35	88	4	GO:0051642
GeneOntologyBiologicalProcess	microtubule organizing center localization	AKAP9 SYNE1 CEP83 CCDC141	1.64e-05	36	88	4	GO:0061842
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	ADCY10 WHRN ARHGEF28 TRIO USP9X SYNE1 GLI3 NTRK3 LRRK2 GOLGA6A SLITRK6 CTTN ATL1	1.65e-05	748	88	13	GO:0048667
GeneOntologyBiologicalProcess	neuron projection morphogenesis	ADCY10 ARHGEF28 TRIO MYO9A USP9X SYNE1 GLI3 NTRK3 LRRK2 GOLGA6A SLITRK6 CTTN ATL1	3.42e-05	802	88	13	GO:0048812
GeneOntologyBiologicalProcess	cilium organization	NEDD9 DNHD1 CCDC88C USP9X SYNE1 CFAP221 FBF1 IQCB1 CEP83 CEP164	3.52e-05	476	88	10	GO:0044782
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	ADCY10 ARHGEF28 TRIO MYO9A USP9X SYNE1 GLI3 NTRK3 LRRK2 GOLGA6A SLITRK6 CTTN ATL1	4.25e-05	819	88	13	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	ADCY10 ARHGEF28 TRIO MYO9A USP9X SYNE1 GLI3 NTRK3 LRRK2 GOLGA6A SLITRK6 CTTN ATL1	4.63e-05	826	88	13	GO:0048858
GeneOntologyBiologicalProcess	positive regulation of sprouting of injured axon	NTRK3 PUM2	5.38e-05	3	88	2	GO:0048687
GeneOntologyBiologicalProcess	positive regulation of cellular component organization	NEDD9 ADCY10 SFTPA2 AKAP9 HDAC4 RAPGEF3 RALBP1 SYNE1 NTRK3 LRRK2 PUM2 SFTPA1 ACTN4 FYCO1 GOLGA6A SLITRK6 CTTN	5.63e-05	1366	88	17	GO:0051130
GeneOntologyBiologicalProcess	Golgi organization	AKAP9 SYNE1 LRRK2 GOLGA6A ATL2 TRIP11	8.33e-05	168	88	6	GO:0007030
GeneOntologyBiologicalProcess	organelle assembly	ABRAXAS2 DNHD1 USP9X SYNE1 NTRK3 CFAP221 FBF1 IQCB1 LRRK2 CEP83 OBSCN PUM2 GOLGA6A CEP164 WDR62	8.70e-05	1138	88	15	GO:0070925
GeneOntologyBiologicalProcess	axon development	ADCY10 ARHGEF28 TRIO USP9X GLI3 NTRK3 PUM2 GOLGA6A SLITRK6 CTTN ATL1	8.88e-05	642	88	11	GO:0061564
GeneOntologyBiologicalProcess	regulation of RIG-I signaling pathway	DDX60 PUM2 PUM1	9.44e-05	21	88	3	GO:0039535
GeneOntologyBiologicalProcess	neuron projection development	ADCY10 WHRN ARHGEF28 TRIO MYO9A USP9X SYNE1 GLI3 NTRK3 LRRK2 PUM2 GOLGA6A SLITRK6 CTTN TRIP11 ATL1	9.58e-05	1285	88	16	GO:0031175
GeneOntologyBiologicalProcess	cytosolic ciliogenesis	USP9X IQCB1	1.07e-04	4	88	2	GO:0061824
GeneOntologyBiologicalProcess	endoplasmic reticulum tubular network membrane organization	ATL2 ATL1	1.07e-04	4	88	2	GO:1990809
GeneOntologyBiologicalProcess	neuron development	ADCY10 WHRN ARHGEF28 TRIO MYO9A USP9X SYNE1 GLI3 NTRK3 LRRK2 PUM2 RORB GOLGA6A SLITRK6 CTTN TRIP11 ATL1	1.31e-04	1463	88	17	GO:0048666
GeneOntologyBiologicalProcess	axonogenesis	ADCY10 ARHGEF28 TRIO USP9X GLI3 NTRK3 GOLGA6A SLITRK6 CTTN ATL1	1.48e-04	566	88	10	GO:0007409
GeneOntologyBiologicalProcess	cell morphogenesis	ADCY10 WHRN CCDC88C ARHGEF28 TRIO MYO9A USP9X SYNE1 GLI3 NTRK3 LRRK2 GOLGA6A SLITRK6 CTTN ATL1	1.48e-04	1194	88	15	GO:0000902
GeneOntologyBiologicalProcess	regulation of sprouting of injured axon	NTRK3 PUM2	1.78e-04	5	88	2	GO:0048686
GeneOntologyBiologicalProcess	cell junction organization	NEDD9 WHRN MYO9A USP9X NTRK3 FBF1 LRRK2 NBEA ACTN4 SLITRK6 ITGA5 CTTN ELFN2	2.40e-04	974	88	13	GO:0034330
GeneOntologyBiologicalProcess	sprouting of injured axon	NTRK3 PUM2	2.67e-04	6	88	2	GO:0048682
GeneOntologyBiologicalProcess	RIG-I signaling pathway	DDX60 PUM2 PUM1	2.80e-04	30	88	3	GO:0039529
GeneOntologyBiologicalProcess	small GTPase-mediated signal transduction	CCDC88C ARHGEF28 TRIO MYO9A RAPGEF3 RALBP1 NUCB1 LRRK2 OBSCN	4.80e-04	538	88	9	GO:0007264
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection assembly	DNHD1 HDAC4 USP9X SYNE1 CFAP221 FBF1 IQCB1 CEP83 CTTN CEP164	5.64e-04	670	88	10	GO:0120031
GeneOntologyBiologicalProcess	endoplasmic reticulum to Golgi vesicle-mediated transport	GOPC LRRK2 GOLGA6A ATL2 TRIP11	5.98e-04	159	88	5	GO:0006888
GeneOntologyBiologicalProcess	cilium assembly	DNHD1 USP9X SYNE1 CFAP221 FBF1 IQCB1 CEP83 CEP164	6.18e-04	444	88	8	GO:0060271
GeneOntologyCellularComponent	ciliary transition fiber	FBF1 CEP83 CEP164	9.06e-06	10	90	3	GO:0097539
GeneOntologyCellularComponent	axon	ADCY10 WHRN SACS TRPM7 MYO9A RAPGEF3 USP9X NTRK3 LRRK2 EEA1 CTTN PUM1 UNC80 ATL1	2.61e-05	891	90	14	GO:0030424
GeneOntologyCellularComponent	postsynapse	WHRN AKAP9 GOPC TRIO MYO9A USP9X SYNE1 NTRK3 LRRK2 NBEA ACTN4 EEA1 ITGA5 CTTN ELFN2	2.75e-05	1018	90	15	GO:0098794
GeneOntologyCellularComponent	microtubule organizing center	NEDD9 ABRAXAS2 WHRN CCDC88C AKAP9 CEP112 USP9X FBF1 IQCB1 CEP83 CCDC141 CEP164 WDR62 KLHL4	3.67e-05	919	90	14	GO:0005815
GeneOntologyCellularComponent	growth cone	ADCY10 WHRN MYO9A RAPGEF3 USP9X LRRK2 CTTN	9.11e-05	245	90	7	GO:0030426
GeneOntologyCellularComponent	site of polarized growth	ADCY10 WHRN MYO9A RAPGEF3 USP9X LRRK2 CTTN	1.11e-04	253	90	7	GO:0030427
GeneOntologyCellularComponent	centrosome	ABRAXAS2 CCDC88C AKAP9 CEP112 USP9X FBF1 IQCB1 CEP83 CCDC141 CEP164 WDR62 KLHL4	1.13e-04	770	90	12	GO:0005813
GeneOntologyCellularComponent	endoplasmic reticulum tubular network membrane	ATL2 ATL1	1.82e-04	5	90	2	GO:0098826
GeneOntologyCellularComponent	spindle pole	NEDD9 ABRAXAS2 RALBP1 FBF1 GOLGA6A WDR62	2.60e-04	205	90	6	GO:0000922
GeneOntologyCellularComponent	cilium	NEDD9 ADCY10 WHRN DNHD1 AKAP9 USP9X GLI3 CFAP221 FBF1 IQCB1 CEP83 CEP164	4.60e-04	898	90	12	GO:0005929
GeneOntologyCellularComponent	cis-Golgi network	AKAP9 GOLIM4 GOLGA6A TRIP11	4.99e-04	85	90	4	GO:0005801
GeneOntologyCellularComponent	glutamatergic synapse	PRUNE2 AKAP9 TRIO MYO9A NTRK3 LRRK2 NBEA EEA1 ITGA5 CTTN PPM1H	7.58e-04	817	90	11	GO:0098978
GeneOntologyCellularComponent	Golgi stack	AKAP9 NUCB1 GOLIM4 GOLGA6A ATL1	8.67e-04	171	90	5	GO:0005795
GeneOntologyCellularComponent	centriole	FBF1 IQCB1 CEP83 CEP164 WDR62	8.90e-04	172	90	5	GO:0005814
GeneOntologyCellularComponent	spindle	NEDD9 ABRAXAS2 RALBP1 FBF1 IQCB1 GOLGA6A CTTN WDR62	9.65e-04	471	90	8	GO:0005819
GeneOntologyCellularComponent	mitotic spindle	NEDD9 IQCB1 GOLGA6A CTTN WDR62	1.77e-03	201	90	5	GO:0072686
GeneOntologyCellularComponent	distal axon	ADCY10 WHRN MYO9A RAPGEF3 USP9X LRRK2 CTTN	2.73e-03	435	90	7	GO:0150034
GeneOntologyCellularComponent	Golgi cisterna	NUCB1 GOLIM4 GOLGA6A ATL1	2.77e-03	135	90	4	GO:0031985
GeneOntologyCellularComponent	postsynaptic actin cytoskeleton	ACTN4 CTTN	2.99e-03	19	90	2	GO:0098871
GeneOntologyCellularComponent	Golgi apparatus subcompartment	AKAP9 NUCB1 LRRK2 GOLIM4 NBEA GOLGA6A ATL1	3.02e-03	443	90	7	GO:0098791
GeneOntologyCellularComponent	lamellar body	SFTPA2 SFTPA1	3.65e-03	21	90	2	GO:0042599
GeneOntologyCellularComponent	Golgi membrane	MAN2A2 GOPC NUCB1 LRRK2 GOLIM4 GOLGA6A ST8SIA3 TRIP11 ATL1	3.85e-03	721	90	9	GO:0000139
GeneOntologyCellularComponent	Z disc	HDAC4 OBSCN ACTN4 RYR1	4.13e-03	151	90	4	GO:0030018
GeneOntologyCellularComponent	sarcomere	HDAC4 SYNE1 OBSCN ACTN4 RYR1	4.45e-03	249	90	5	GO:0030017
GeneOntologyCellularComponent	Schaffer collateral - CA1 synapse	TRIO MYO9A RALBP1 EEA1	4.53e-03	155	90	4	GO:0098685
MousePheno	abnormal podocyte adhesion	MYO9A ACTN4	2.76e-05	2	74	2	MP:0011864
MousePheno	abnormal right lung middle lobe morphology	GLI3 ZFPM2	2.76e-05	2	74	2	MP:0009573
MousePheno	abnormal grooming behavior	HDAC4 SYNE1 LRRK2 NBEA CCDC141 ELFN2	8.51e-05	137	74	6	MP:0001440
MousePheno	abnormal pulmonary alveolar parenchyma morphology	SFTPA2 LRRK2 SFTPA1 GOLGA6A TRIP11	1.12e-04	90	74	5	MP:0010901
MousePheno	heart right ventricle outflow tract stenosis	NTRK3 TRIP11 ZFPM2	1.30e-04	19	74	3	MP:0010449
MousePheno	pulmonary valve hyperplasia	NTRK3 ZFPM2	1.65e-04	4	74	2	MP:0031529
MousePheno	semilunar valve hyperplasia	NTRK3 ZFPM2	1.65e-04	4	74	2	MP:0031581
MousePheno	premature lambdoid suture closure	HDAC4 GLI3	1.65e-04	4	74	2	MP:0030356
MousePheno	abnormal cell motility	NEDD9 ADCY10 DNHD1 ARHGEF28 GOPC TRIO MYO9A GLI3 ACTN4 GOLGA6A ITGA5 CTTN CCDC141 WDR62	1.93e-04	885	74	14	MP:0020846
Domain	Spectrin	TRIO SYNE1 ACTN4 CCDC141	3.63e-06	23	87	4	PF00435
Domain	Spectrin_repeat	TRIO SYNE1 ACTN4 CCDC141	9.54e-06	29	87	4	IPR002017
Domain	Pumilio_RNA-bd	PUM2 PUM1	2.14e-05	2	87	2	IPR033712
Domain	PUM-HD	PUM2 PUM1	6.42e-05	3	87	2	IPR033133
Domain	PUF	PUM2 PUM1	6.42e-05	3	87	2	PF00806
Domain	PUM_HD	PUM2 PUM1	6.42e-05	3	87	2	PS50303
Domain	Pumilio_RNA-bd_rpt	PUM2 PUM1	1.28e-04	4	87	2	IPR001313
Domain	PUM	PUM2 PUM1	1.28e-04	4	87	2	PS50302
Domain	Pumilio	PUM2 PUM1	1.28e-04	4	87	2	SM00025
Domain	IQ	RNF32 MYO9A IQCB1 OBSCN	3.36e-04	71	87	4	PF00612
Domain	LRR	LRR1 NTRK3 LRRK2 SLITRK6 ELFN2 BGN	3.53e-04	201	87	6	PS51450
Domain	Spectrin/alpha-actinin	TRIO SYNE1 ACTN4	4.39e-04	32	87	3	IPR018159
Domain	SPEC	TRIO SYNE1 ACTN4	4.39e-04	32	87	3	SM00150
Domain	IQ	RNF32 MYO9A IQCB1 OBSCN	5.56e-04	81	87	4	SM00015
Domain	LRR_1	LRR1 NTRK3 LRRK2 SLITRK6 ELFN2 BGN	5.56e-04	219	87	6	PF00560
Domain	IQ_motif_EF-hand-BS	RNF32 MYO9A IQCB1 OBSCN	8.27e-04	90	87	4	IPR000048
Domain	IQ	RNF32 MYO9A IQCB1 OBSCN	9.35e-04	93	87	4	PS50096
Domain	Leu-rich_rpt_4	LRR1 LRRK2	9.42e-04	10	87	2	IPR025875
Domain	LRR_4	LRR1 LRRK2	9.42e-04	10	87	2	PF12799
Domain	GBP_C	ATL2 ATL1	9.42e-04	10	87	2	PF02841
Domain	C-type_lectin_CS	SFTPA2 ASGR1 SFTPA1	1.05e-03	43	87	3	IPR018378
Domain	G_GB1_RHD3_dom	ATL2 ATL1	1.15e-03	11	87	2	IPR030386
Domain	Guanylate-bd_C	ATL2 ATL1	1.15e-03	11	87	2	IPR003191
Domain	GBP	ATL2 ATL1	1.15e-03	11	87	2	PF02263
Domain	Guanylate-bd_N	ATL2 ATL1	1.15e-03	11	87	2	IPR015894
Domain	G_GB1_RHD3	ATL2 ATL1	1.15e-03	11	87	2	PS51715
Domain	LRR_8	NTRK3 LRRK2 SLITRK6 ELFN2 BGN	1.22e-03	171	87	5	PF13855
Domain	Leu-rich_rpt_typical-subtyp	LRR1 LRRK2 SLITRK6 ELFN2 BGN	1.43e-03	177	87	5	IPR003591
Domain	LRR_TYP	LRR1 LRRK2 SLITRK6 ELFN2 BGN	1.43e-03	177	87	5	SM00369
Domain	ARM-like	USP9X IQCB1 LRRK2 PUM2 NBEA PUM1	1.64e-03	270	87	6	IPR011989
Domain	Leu-rich_rpt	LRR1 NTRK3 LRRK2 SLITRK6 ELFN2 BGN	1.67e-03	271	87	6	IPR001611
Domain	DH_1	ARHGEF28 TRIO OBSCN	3.17e-03	63	87	3	PS00741
Domain	ConA-like_dom	FSD1L LAMA4 NBEA TRIM34 RYR1	3.59e-03	219	87	5	IPR013320
Domain	-	LRR1 NTRK3 LRRK2 SLITRK6 ELFN2 BGN	3.87e-03	321	87	6	3.80.10.10
Domain	RhoGEF	ARHGEF28 TRIO OBSCN	3.93e-03	68	87	3	SM00325
Domain	CRAL_TRIO	PRUNE2 TRIO	4.25e-03	21	87	2	PF00650
Domain	RhoGEF	ARHGEF28 TRIO OBSCN	4.27e-03	70	87	3	PF00621
Domain	DH_2	ARHGEF28 TRIO OBSCN	4.27e-03	70	87	3	PS50010
Domain	L_dom-like	LRR1 NTRK3 LRRK2 SLITRK6 ELFN2 BGN	4.30e-03	328	87	6	IPR032675
Domain	DH-domain	ARHGEF28 TRIO OBSCN	4.44e-03	71	87	3	IPR000219
Domain	-	ARHGEF28 TRIO OBSCN	4.44e-03	71	87	3	1.20.900.10
Domain	ARM-type_fold	USP9X IQCB1 LRRK2 PUM2 NBEA PUM1	5.04e-03	339	87	6	IPR016024
Domain	Actinin_actin-bd_CS	SYNE1 ACTN4	5.09e-03	23	87	2	IPR001589
Domain	-	PRUNE2 TRIO	5.09e-03	23	87	2	3.40.525.10
Domain	ACTININ_2	SYNE1 ACTN4	5.09e-03	23	87	2	PS00020
Domain	ACTININ_1	SYNE1 ACTN4	5.09e-03	23	87	2	PS00019
Domain	P-loop_NTPase	ADCY10 DNHD1 MYO9A DDX60 IQCB1 LRRK2 DDX60L SLFN5 ATL2 ATL1	5.99e-03	848	87	10	IPR027417
Domain	SEC14	PRUNE2 TRIO	6.00e-03	25	87	2	SM00516
Domain	C_TYPE_LECTIN_1	SFTPA2 ASGR1 SFTPA1	6.20e-03	80	87	3	PS00615
Domain	CRAL_TRIO	PRUNE2 TRIO	6.98e-03	27	87	2	PS50191
Domain	Lectin_C	SFTPA2 ASGR1 SFTPA1	7.09e-03	84	87	3	PF00059
Domain	CLECT	SFTPA2 ASGR1 SFTPA1	7.09e-03	84	87	3	SM00034
Domain	C_TYPE_LECTIN_2	SFTPA2 ASGR1 SFTPA1	7.32e-03	85	87	3	PS50041
Domain	CRAL-TRIO_dom	PRUNE2 TRIO	7.49e-03	28	87	2	IPR001251
Domain	C-type_lectin-like	SFTPA2 ASGR1 SFTPA1	7.56e-03	86	87	3	IPR001304
Domain	SPRY	FSD1L TRIM34 RYR1	7.81e-03	87	87	3	SM00449
Domain	FYVE	FYCO1 EEA1	8.03e-03	29	87	2	PF01363
Domain	FYVE	FYCO1 EEA1	8.03e-03	29	87	2	SM00064
Domain	Cys-rich_flank_reg_C	NTRK3 SLITRK6 ELFN2	8.57e-03	90	87	3	IPR000483
Domain	LRRCT	NTRK3 SLITRK6 ELFN2	8.57e-03	90	87	3	SM00082
Pathway	REACTOME_ANCHORING_OF_THE_BASAL_BODY_TO_THE_PLASMA_MEMBRANE	AKAP9 FBF1 IQCB1 CEP83 CEP164	1.20e-04	96	71	5	MM15207
Pathway	REACTOME_ANCHORING_OF_THE_BASAL_BODY_TO_THE_PLASMA_MEMBRANE	AKAP9 FBF1 IQCB1 CEP83 CEP164	1.26e-04	97	71	5	M27478
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	ADCY10 DNHD1 CCDC88C MYO9A CEP112 DDX60 LRRK2 FYCO1 RYR1	3.82e-09	208	90	9	33230847
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	NEDD9 MAN2A2 AKAP9 TRIO RALBP1 SYNE1 OBSCN LAMA4 ACTN4 CCDC141 TRIP11 RYR1	6.35e-09	497	90	12	23414517
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CCDC88C ARHGEF28 AKAP9 HDAC4 TRIO TRPM7 MYO9A CEP112 NTRK3 IQCB1 PUM1 TRIP11 PPM1H WDR62	4.63e-08	861	90	14	36931259
Pubmed	Centriole distal appendages promote membrane docking, leading to cilia initiation.	FBF1 CEP83 CEP164	1.67e-07	5	90	3	23348840
Pubmed	Molecular embryology of the lung: then, now, and in the future.	SFTPA2 GLI3 SFTPA1	3.33e-07	6	90	3	10330024
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZNF18 TRIO SACS TRPM7 USP9X RALBP1 SYNE1 NUCB1 NBEA RORB ACTN4 CTTN TRIP11 TXLNG KLHL4	1.02e-06	1285	90	15	35914814
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CCDC88C AKAP9 HDAC4 TRIO USP9X SYNE1 CALCOCO1 NBEA FYCO1 GOLGA6A CTTN TRIP11 PPM1H	1.19e-06	963	90	13	28671696
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	ABRAXAS2 CCDC88C AKAP9 HDAC4 USP9X FBF1 PUM1 PPM1H WDR62	2.44e-06	446	90	9	24255178
Pubmed	Airway epithelial cell differentiation during lung organogenesis requires C/EBPα and C/EBPβ.	SFTPA2 CEBPG SFTPA1	5.97e-06	14	90	3	22411169
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	LRR1 TBRG4 SFTPA2 USP9X PHF12 FBF1 NBEA ITGA5 TRIP11 RYR1	6.16e-06	638	90	10	31182584
Pubmed	Major Effect of Oxidative Stress on the Male, but Not Female, SP-A1 Type II Cell miRNome.	SFTPA2 SFTPA1	6.62e-06	2	90	2	31354704
Pubmed	Signaling Pathways That Mediate Alveolar Macrophage Activation by Surfactant Protein A and IL-4.	SFTPA2 SFTPA1	6.62e-06	2	90	2	35444643
Pubmed	Surfactant-associated protein A inhibits LPS-induced cytokine and nitric oxide production in vivo.	SFTPA2 SFTPA1	6.62e-06	2	90	2	10749762
Pubmed	The flagellum of Pseudomonas aeruginosa is required for resistance to clearance by surfactant protein A.	SFTPA2 SFTPA1	6.62e-06	2	90	2	17593964
Pubmed	Studies of the structure of lung surfactant protein SP-A.	SFTPA2 SFTPA1	6.62e-06	2	90	2	2610270
Pubmed	Surfactant protein-A binds group B streptococcus enhancing phagocytosis and clearance from lungs of surfactant protein-A-deficient mice.	SFTPA2 SFTPA1	6.62e-06	2	90	2	9922219
Pubmed	Maternal surfactant protein A influences the immunoprotective properties of milk in a murine model.	SFTPA2 SFTPA1	6.62e-06	2	90	2	24858142
Pubmed	Surfactant protein-A--deficient mice display an exaggerated early inflammatory response to a beta-resistant strain of influenza A virus.	SFTPA2 SFTPA1	6.62e-06	2	90	2	11867335
Pubmed	Pneumocystis murina colonization in immunocompetent surfactant protein A deficient mice following environmental exposure.	SFTPA2 SFTPA1	6.62e-06	2	90	2	19228388
Pubmed	SP-A preserves airway homeostasis during Mycoplasma pneumoniae infection in mice.	SFTPA2 SFTPA1	6.62e-06	2	90	2	19494306
Pubmed	An 11-nt sequence polymorphism at the 3'UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture.	SFTPA2 SFTPA1	6.62e-06	2	90	2	24793167
Pubmed	Sex differences in the acute in vivo effects of different human SP-A variants on the mouse alveolar macrophage proteome.	SFTPA2 SFTPA1	6.62e-06	2	90	2	24954098
Pubmed	Characterization of a second human pulmonary surfactant-associated protein SP-A gene.	SFTPA2 SFTPA1	6.62e-06	2	90	2	1372511
Pubmed	Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation.	SFTPA2 SFTPA1	6.62e-06	2	90	2	21257967
Pubmed	The Pseudomonas aeruginosa flagellum confers resistance to pulmonary surfactant protein-A by impacting the production of exoproteases through quorum-sensing.	SFTPA2 SFTPA1	6.62e-06	2	90	2	21205009
Pubmed	Surfactant protein A modulates neuroinflammation in adult mice upon pulmonary infection.	SFTPA2 SFTPA1	6.62e-06	2	90	2	38964703
Pubmed	Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants.	SFTPA2 SFTPA1	6.62e-06	2	90	2	34917085
Pubmed	Surfactant protein A integrates activation signal strength to differentially modulate T cell proliferation.	SFTPA2 SFTPA1	6.62e-06	2	90	2	22219327
Pubmed	Surfactant protein A is a principal and oxidation-sensitive microbial permeabilizing factor in the alveolar lining fluid.	SFTPA2 SFTPA1	6.62e-06	2	90	2	15890661
Pubmed	Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen species.	SFTPA2 SFTPA1	6.62e-06	2	90	2	15385504
Pubmed	A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation.	SFTPA2 SFTPA1	6.62e-06	2	90	2	23475791
Pubmed	Surfactant protein A associated with respiratory distress syndrome in Korean preterm infants: evidence of ethnic difference.	SFTPA2 SFTPA1	6.62e-06	2	90	2	23038062
Pubmed	Surfactant protein A binds flagellin enhancing phagocytosis and IL-1β production.	SFTPA2 SFTPA1	6.62e-06	2	90	2	24312669
Pubmed	Correlation analysis between single nucleotide polymorphisms of pulmonary surfactant protein A gene and pulmonary tuberculosis in the Han population in China.	SFTPA2 SFTPA1	6.62e-06	2	90	2	24984162
Pubmed	Effect of cysteine 85 on biochemical properties and biological function of human surfactant protein A variants.	SFTPA2 SFTPA1	6.62e-06	2	90	2	17580966
Pubmed	Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.	PUM2 PUM1	6.62e-06	2	90	2	12459267
Pubmed	Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.	PUM2 PUM1	6.62e-06	2	90	2	29165587
Pubmed	NEDD9 is transcriptionally regulated by HDAC4 and promotes breast cancer metastasis and macrophage M2 polarization via the FAK/NF-κB signaling pathway.	NEDD9 HDAC4	6.62e-06	2	90	2	39326322
Pubmed	Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein.	SFTPA2 SFTPA1	6.62e-06	2	90	2	3755136
Pubmed	Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences.	SFTPA2 SFTPA1	6.62e-06	2	90	2	29394894
Pubmed	Surfactant protein-A suppresses eosinophil-mediated killing of Mycoplasma pneumoniae in allergic lungs.	SFTPA2 SFTPA1	6.62e-06	2	90	2	22384248
Pubmed	Surfactant protein A enhances production of secretory leukoprotease inhibitor and protects it from cleavage by matrix metalloproteinases.	SFTPA2 SFTPA1	6.62e-06	2	90	2	19155504
Pubmed	Surfactant Protein A can Affect the Surface Tension of the Eustachian Tube and Macrophage Migration.	SFTPA2 SFTPA1	6.62e-06	2	90	2	36102297
Pubmed	Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice.	SFTPA2 SFTPA1	6.62e-06	2	90	2	17307210
Pubmed	PUMILIO-mediated translational control of somatic cell cycle program promotes folliculogenesis and contributes to ovarian cancer progression.	PUM2 PUM1	6.62e-06	2	90	2	35507203
Pubmed	Bespoke RNA recognition by Pumilios.	PUM2 PUM1	6.62e-06	2	90	2	26517885
Pubmed	Surfactant protein A modulates induction of regulatory T cells via TGF-β.	SFTPA2 SFTPA1	6.62e-06	2	90	2	22474025
Pubmed	Mouse Pum1 and Pum2 genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal and adult hematopoietic stem cells and progenitors.	PUM2 PUM1	6.62e-06	2	90	2	12667987
Pubmed	Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer.	PUM2 PUM1	6.62e-06	2	90	2	12771951
Pubmed	Reconstitution of human atlastin fusion activity reveals autoinhibition by the C terminus.	ATL2 ATL1	6.62e-06	2	90	2	34817557
Pubmed	The collagen-like region of surfactant protein A (SP-A) is required for correction of surfactant structural and functional defects in the SP-A null mouse.	SFTPA2 SFTPA1	6.62e-06	2	90	2	11504713
Pubmed	Surfactant protein A promotes western diet-induced hepatic steatosis and fibrosis in mice.	SFTPA2 SFTPA1	6.62e-06	2	90	2	38553537
Pubmed	Alternate modes of cognate RNA recognition by human PUMILIO proteins.	PUM2 PUM1	6.62e-06	2	90	2	21397187
Pubmed	Surfactant protein A reduces TLR4 and inflammatory cytokine mRNA levels in neonatal mouse ileum.	SFTPA2 SFTPA1	6.62e-06	2	90	2	33510368
Pubmed	Genetic complexity of the human innate host defense molecules, surfactant protein A1 (SP-A1) and SP-A2--impact on function.	SFTPA2 SFTPA1	6.62e-06	2	90	2	19392648
Pubmed	Polymorphisms in the surfactant protein a gene are associated with the susceptibility to recurrent urinary tract infection in chinese women.	SFTPA2 SFTPA1	6.62e-06	2	90	2	20448439
Pubmed	Humanized SFTPA1 and SFTPA2 transgenic mice reveal functional divergence of SP-A1 and SP-A2: formation of tubular myelin in vivo requires both gene products.	SFTPA2 SFTPA1	6.62e-06	2	90	2	20048345
Pubmed	Functional assessment and phenotypic heterogeneity of SFTPA1 and SFTPA2 mutations in interstitial lung diseases and lung cancer.	SFTPA2 SFTPA1	6.62e-06	2	90	2	32855221
Pubmed	Surfactant protein A suppresses lipopolysaccharide-induced IL-10 production by murine macrophages.	SFTPA2 SFTPA1	6.62e-06	2	90	2	11342662
Pubmed	Surfactant protein A-deficient mice are susceptible to group B streptococcal infection.	SFTPA2 SFTPA1	6.62e-06	2	90	2	9126996
Pubmed	Type IV pilus of Pseudomonas aeruginosa confers resistance to antimicrobial activities of the pulmonary surfactant protein-A.	SFTPA2 SFTPA1	6.62e-06	2	90	2	24080545
Pubmed	Lung development in the mouse embryo.	SFTPA2 SFTPA1	6.62e-06	2	90	2	2050021
Pubmed	Murine pulmonary surfactant SP-A gene: cloning, sequence, and transcriptional activity.	SFTPA2 SFTPA1	6.62e-06	2	90	2	1443158
Pubmed	Surfactant Protein A and B Gene Polymorphisms and Risk of Respiratory Distress Syndrome in Late-Preterm Neonates.	SFTPA2 SFTPA1	6.62e-06	2	90	2	27835691
Pubmed	Genetic Variation in Surfactant Protein-A2 Delays Resolution of Eosinophilia in Asthma.	SFTPA2 SFTPA1	6.62e-06	2	90	2	31350355
Pubmed	Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2.	SFTPA2 SFTPA1	6.62e-06	2	90	2	23069847
Pubmed	Ablation of SP-A has a negative impact on the susceptibility of mice to Klebsiella pneumoniae infection after ozone exposure: sex differences.	SFTPA2 SFTPA1	6.62e-06	2	90	2	19055785
Pubmed	Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions.	SFTPA2 SFTPA1	6.62e-06	2	90	2	34484180
Pubmed	Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain.	LRRK2 PPM1H	6.62e-06	2	90	2	34658337
Pubmed	Surfactant protein A limits Pneumocystis murina infection in immunosuppressed C3H/HeN mice and modulates host response during infection.	SFTPA2 SFTPA1	6.62e-06	2	90	2	15857803
Pubmed	Surfactant protein-A reduces translocation of mediators from the lung into the circulation.	SFTPA2 SFTPA1	6.62e-06	2	90	2	20715984
Pubmed	A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins.	PUM2 PUM1	6.62e-06	2	90	2	31078383
Pubmed	Effects of surfactant protein-A on the interaction of Pneumocystis murina with its host at different stages of the infection in mice.	SFTPA2 SFTPA1	6.62e-06	2	90	2	19335775
Pubmed	Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas.	PRUNE2 OBSCN	6.62e-06	2	90	2	17360660
Pubmed	Altered surfactant protein A gene expression and protein metabolism associated with repeat exposure to inhaled endotoxin.	SFTPA2 SFTPA1	6.62e-06	2	90	2	12922979
Pubmed	Cryptococcus neoformans is resistant to surfactant protein A mediated host defense mechanisms.	SFTPA2 SFTPA1	6.62e-06	2	90	2	18159253
Pubmed	Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis.	PUM2 PUM1	6.62e-06	2	90	2	32753408
Pubmed	Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice.	SFTPA2 SFTPA1	6.62e-06	2	90	2	33141765
Pubmed	Localization of PPM1H phosphatase tunes Parkinson's disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis.	LRRK2 PPM1H	6.62e-06	2	90	2	37889931
Pubmed	Regulatory roles of SP-A and exosomes in pneumonia-induced acute lung and kidney injuries.	SFTPA2 SFTPA1	6.62e-06	2	90	2	37256132
Pubmed	Surfactant protein a attenuates generalized and localized neuroinflammation in neonatal mice.	SFTPA2 SFTPA1	6.62e-06	2	90	2	36871846
Pubmed	Innate immunity of surfactant protein A in experimental otitis media.	SFTPA2 SFTPA1	6.62e-06	2	90	2	31378117
Pubmed	Surfactant Protein A, a Novel Regulator for Smooth Muscle Phenotypic Modulation and Vascular Remodeling-Brief Report.	SFTPA2 SFTPA1	6.62e-06	2	90	2	33267655
Pubmed	PUMILIO proteins promote colorectal cancer growth via suppressing p21.	PUM2 PUM1	6.62e-06	2	90	2	35338151
Pubmed	Effects of PUMILIO1 and PUMILIO2 knockdown on cardiomyogenic differentiation of human embryonic stem cells culture.	PUM2 PUM1	6.62e-06	2	90	2	32437472
Pubmed	Immunosuppressed surfactant protein A-deficient mice have increased susceptibility to Pneumocystis carinii infection.	SFTPA2 SFTPA1	6.62e-06	2	90	2	11237812
Pubmed	Human SP-A protein variants derived from one or both genes stimulate TNF-alpha production in the THP-1 cell line.	SFTPA2 SFTPA1	6.62e-06	2	90	2	10781424
Pubmed	SP-A is necessary for increased clearance of alveolar DPPC with hyperventilation or secretagogues.	SFTPA2 SFTPA1	6.62e-06	2	90	2	12676766
Pubmed	Surfactant protein A deficiency exacerbates renal interstitial fibrosis following obstructive injury in mice.	SFTPA2 SFTPA1	6.62e-06	2	90	2	27916681
Pubmed	Surfactant protein A inhibits alveolar macrophage cytokine production by CD14-independent pathway.	SFTPA2 SFTPA1	6.62e-06	2	90	2	12959932
Pubmed	Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition.	SFTPA2 SFTPA1	6.62e-06	2	90	2	15044702
Pubmed	AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties.	AKAP9 RAPGEF3	6.62e-06	2	90	2	20952690
Pubmed	Structural comparison of recombinant pulmonary surfactant protein SP-A derived from two human coding sequences: implications for the chain composition of natural human SP-A.	SFTPA2 SFTPA1	6.62e-06	2	90	2	1986781
Pubmed	Surfactant protein A is a required mediator of keratinocyte growth factor after experimental marrow transplantation.	SFTPA2 SFTPA1	6.62e-06	2	90	2	12740217
Pubmed	Surfactant protein-A plays an important role in lung surfactant clearance: evidence using the surfactant protein-A gene-targeted mouse.	SFTPA2 SFTPA1	6.62e-06	2	90	2	18083768
Pubmed	Structural characterisation of human proteinosis surfactant protein A.	SFTPA2 SFTPA1	6.62e-06	2	90	2	11087951
Pubmed	Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system.	PUM2 PUM1	6.62e-06	2	90	2	18776931
Pubmed	Surfactant protein-A inhibits Aspergillus fumigatus-induced allergic T-cell responses.	SFTPA2 SFTPA1	6.62e-06	2	90	2	16120217
Pubmed	SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved.	SFTPA2 SFTPA1	6.62e-06	2	90	2	29202868
Pubmed	The alveolar macrophage toponome of female SP-A knockout mice differs from that of males before and after SP-A1 rescue.	SFTPA2 SFTPA1	6.62e-06	2	90	2	35322074
Interaction	PCM1 interactions	AKAP9 HDAC4 MYO9A CEP112 USP9X RALBP1 FBF1 IQCB1 GOLGA6A EEA1 TXLNG CEP164	4.00e-07	434	88	12	int:PCM1
Interaction	SFN interactions	CCDC88C ARHGEF28 AKAP9 HDAC4 TRPM7 MYO9A CEP112 NTRK3 LRRK2 EEA1 PUM1 TRIP11 WDR62	9.25e-06	692	88	13	int:SFN
Interaction	KRT38 interactions	CEBPG HDAC4 MYO9A FYCO1 EEA1 TXLNG CEP164	1.04e-05	172	88	7	int:KRT38
Interaction	ANPEP interactions	GOPC TRPM7 USP9X NADK2 NBEA ACTN4 TRIP11	1.12e-05	174	88	7	int:ANPEP
Interaction	GUSBP5 interactions	PHF12 IQCB1 PUM2 PUM1 CEP164	1.92e-05	75	88	5	int:GUSBP5
GeneFamily	Collectins	SFTPA2 SFTPA1	4.32e-04	10	57	2	491
Coexpression	LAKE_ADULT_KIDNEY_C29_UNKNOWN_NOVEL_PT_CFH_POS_SUBPOPULATION_S2	NEDD9 PRUNE2 MYO9A CEP112 SYNE1 ZFPM2	5.22e-07	86	90	6	M39248
Coexpression	GSE9946_IMMATURE_VS_LISTERIA_INF_MATURE_DC_UP	GOPC LRRK2 OBSCN SFTPA1 NBEA CRACR2B	8.98e-06	140	90	6	M418
Coexpression	RAPA_EARLY_UP.V1_UP	ADCY10 CCDC88C NUCB1 GREB1 ITGA5 ST8SIA3	2.45e-05	167	90	6	M2644
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#5_top-relative-expression-ranked_1000	NEDD9 ARHGEF28 AKAP9 TRIO TRPM7 USP9X RALBP1 ATL2 CEP164	1.37e-05	339	90	9	gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_1000_k5
CoexpressionAtlas	DevelopingKidney_e15.5_Medullary collecting duct_emap-28063_k-means-cluster#4_top-relative-expression-ranked_1000	ARHGEF28 AKAP9 GOPC USP9X RALBP1 ATL2 CCDC141 CEP164	1.52e-05	261	90	8	gudmap_developingKidney_e15.5_Medullary collecting duct_1000_k4
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYO9A SYNE1 GLI3 CFAP221 LRRK2 PPM1H	1.03e-07	186	90	7	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 PRUNE2 TRIO MYO9A SYNE1 LRRK2 PPM1H	1.11e-07	188	90	7	63a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell	(02)_MMP9/10+-(2)_GFP_FOXI1\|(02)_MMP9/10+ / shred by cell type by condition	AKAP9 RALBP1 GOLIM4 PARP9 SLFN5 EEA1 TRIP11	1.63e-07	199	90	7	18a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PRUNE2 SACS NTRK3 LAMA4 ITGA5 ZFPM2	1.41e-06	173	90	6	cb6389536195443633adb06e5f1b7483530773d1
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM7 MYO9A CEP112 GOLIM4 TRIP11 ZNF260	1.56e-06	176	90	6	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 PRUNE2 MYO9A SYNE1 LRRK2 PPM1H	1.56e-06	176	90	6	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	SFTPA2 SYNE1 CFAP221 LRRK2 SFTPA1 CCDC141	1.78e-06	180	90	6	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	TRIO USP9X DDX60 PARP9 DDX60L SLFN5	1.96e-06	183	90	6	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYO9A GLI3 CFAP221 LRRK2 PPM1H	2.22e-06	187	90	6	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	SFTPA2 TMEM191B CFAP221 LRRK2 SFTPA1 CTTN	2.36e-06	189	90	6	2d32f09efa982ae458568f6b1cd06bb5078d42a3
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 TRIO MYO9A CFAP221 LRRK2 PPM1H	2.51e-06	191	90	6	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SFTPA2 SYNE1 CFAP221 LRRK2 SFTPA1 CCDC141	2.66e-06	193	90	6	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SFTPA2 SYNE1 CFAP221 LRRK2 SFTPA1 CCDC141	2.66e-06	193	90	6	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF28 MYO9A SYNE1 CFAP221 LRRK2 PPM1H	2.74e-06	194	90	6	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	nucseq-Mesenchymal-Myocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GLI3 NTRK3 OBSCN LAMA4 ZFPM2 BGN	2.74e-06	194	90	6	2d66091097e106c7bee22e5281f50724700bdf8d
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SFTPA2 MYO9A SYNE1 LRRK2 SFTPA1 CCDC141	2.74e-06	194	90	6	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SFTPA2 MYO9A SYNE1 CFAP221 LRRK2 SFTPA1	2.82e-06	195	90	6	9406866f99555198a9be311fbd65751b70f35446
ToppCell	Control_saline-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	FSD1L ARHGEF28 SFTPA2 AKAP9 LRRK2 CCDC141	2.99e-06	197	90	6	44a59dfb889577b3160a5b13ada1276771a00241
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FSD1L ARHGEF28 SFTPA2 AKAP9 LRRK2 CCDC141	2.99e-06	197	90	6	1485933986921ff45669d9b7501c8d17050b3e97
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FSD1L ARHGEF28 SFTPA2 AKAP9 LRRK2 CCDC141	3.08e-06	198	90	6	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	AKAP9 RALBP1 PARP9 SLFN5 EEA1 TRIP11	3.17e-06	199	90	6	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	(04)_Interm._basal>secr.-(2)_GFP_FOXI1\|(04)_Interm._basal>secr. / shred by cell type by condition	AKAP9 RALBP1 PARP9 SLFN5 EEA1 TRIP11	3.17e-06	199	90	6	53ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	AKAP9 RALBP1 PARP9 SLFN5 EEA1 TRIP11	3.17e-06	199	90	6	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	(05)_Secretory-(2)_GFP_FOXI1\|(05)_Secretory / shred by cell type by condition	AKAP9 RALBP1 PARP9 SLFN5 EEA1 TRIP11	3.17e-06	199	90	6	d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCell	(01)_IL1RL1+-(2)_GFP_FOXI1\|(01)_IL1RL1+ / shred by cell type by condition	NEDD9 AKAP9 GOLIM4 SLFN5 EEA1 TRIP11	3.17e-06	199	90	6	a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FSD1L ARHGEF28 SFTPA2 AKAP9 LRRK2 CCDC141	3.27e-06	200	90	6	e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PRUNE2 SYNE1 LAMA4 SLITRK6 ZFPM2 BGN	3.27e-06	200	90	6	08bf8c00eee6468215edb3611296bfc8784c4d56
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	PRUNE2 SYNE1 LAMA4 SLITRK6 ZFPM2 BGN	3.27e-06	200	90	6	02cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PRUNE2 SYNE1 NTRK3 LAMA4 ZFPM2 BGN	3.27e-06	200	90	6	dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCell	Thalamus\|World / BrainAtlas - Mouse McCarroll V32	CFAP221 RORB SLITRK6 CCDC141 TRIP11	3.85e-06	116	90	5	5ddfb2dd5459ff6d7ae38163a38eae64fda283b7
ToppCell	(08)_Brush+PNEC-(2)_GFP_FOXI1\|(08)_Brush+PNEC / shred by cell type by condition	AKAP9 RALBP1 PARP9 SLFN5 TRIP11	9.00e-06	138	90	5	817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCell	MS-CD4-antiviral_CD4\|MS / Condition, Cell_class and T cell subcluster	ADCY10 DDX60 PARP9 DDX60L SLFN5	1.44e-05	152	90	5	b1eba2d5a6da3eeb83d40a92976e3e8751ed18ee
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SACS RAPGEF3 SYNE1 ZFPM2 BGN	1.63e-05	156	90	5	dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SACS RAPGEF3 SYNE1 ZFPM2 BGN	1.63e-05	156	90	5	abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCell	368C-Epithelial_cells-Epithelial-A_(AT2)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	SFTPA2 LRRK2 SFTPA1 CCDC141 ELFN2	2.07e-05	164	90	5	85f53d184fa70e3eb1af655807f32b17ddbfb304
ToppCell	368C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ADCY10 ARHGEF28 NTRK3 SLITRK6 CCDC141	2.07e-05	164	90	5	dd29decc6c41a580cfdf03962827ec18d432935f
ToppCell	368C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ADCY10 ARHGEF28 NTRK3 SLITRK6 CCDC141	2.07e-05	164	90	5	dcd3c3ee73900180451fad9b4de0efedbd375e1c
ToppCell	368C-Epithelial_cells-Epithelial-A_(AT2)\|368C / Donor, Lineage, Cell class and subclass (all cells)	SFTPA2 LRRK2 SFTPA1 CCDC141 ELFN2	2.07e-05	164	90	5	144ba070a1ede71684224cc6d4ead3b7e6a7b4c6
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Stem_cells-neuroepithelial-like_cells\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	RNF32 WHRN CFAP221 OBSCN CRACR2B	2.26e-05	167	90	5	e488d9c7cf4355959e3833de3bd496c13fc11b1b
ToppCell	Control-Fibroblasts-Pericytes\|Control / group, cell type (main and fine annotations)	NTRK3 OBSCN LAMA4 ZFPM2 BGN	2.53e-05	171	90	5	080003f698f867935c2bfc55d241d3650f45a0ab
ToppCell	COVID-19-kidney-PEC\|kidney / Disease (COVID-19 only), tissue and cell type	PRUNE2 SACS SYNE1 LAMA4 ZFPM2	2.60e-05	172	90	5	36a96714a0eb6ac438648135336c9791881ddadb
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RNF32 PRUNE2 SACS LRRK2 TFAP2C	2.91e-05	176	90	5	33323c97afe509147956b8df9f92ca6b0537e604
ToppCell	368C-Epithelial_cells-Epithelial-B_(AT2)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	SFTPA2 LRRK2 SFTPA1 RORB CCDC141	2.99e-05	177	90	5	ac8f774596068e66c0a9ea8a318be0ce5f5df834
ToppCell	368C-Epithelial_cells-Epithelial-B_(AT2)\|368C / Donor, Lineage, Cell class and subclass (all cells)	SFTPA2 LRRK2 SFTPA1 RORB CCDC141	2.99e-05	177	90	5	d9c4a93b0e04a13bf39992dd1c1ec8df2c5f89fe
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88C AKAP9 SYNE1 SLFN5 TRIP11	3.07e-05	178	90	5	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	COVID-19-kidney-Epi_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 ARHGEF28 MYO9A RAPGEF3 PPM1H	3.07e-05	178	90	5	544379f5a6145429762258d426b876bb36c112f5
ToppCell	Control-Fibroblasts-Airway_smooth_muscle\|Control / group, cell type (main and fine annotations)	PRUNE2 NTRK3 LAMA4 ITGA5 ZFPM2	3.24e-05	180	90	5	d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 MYO9A CFAP221 LRRK2 PPM1H	3.32e-05	181	90	5	6a6bd8e020cb0929b6ecdcb55d467ad24fecfaf0
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYO9A CFAP221 LRRK2 PPM1H	3.32e-05	181	90	5	9d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCell	RV\|World / Chamber and Cluster_Paper	AKAP9 TRPM7 OBSCN LAMA4 CCDC141	3.32e-05	181	90	5	bbe1e6e59d8889bd37d6e8303116cbdcafca7236
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 PRUNE2 MYO9A LRRK2 ADGRF4	3.32e-05	181	90	5	6956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 RAPGEF3 SYNE1 ZFPM2 BGN	3.32e-05	181	90	5	5f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 RAPGEF3 SYNE1 ZFPM2 BGN	3.32e-05	181	90	5	c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYO9A CFAP221 LRRK2 PPM1H	3.41e-05	182	90	5	eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA4 NBEA CRACR2B ZFPM2 BGN	3.41e-05	182	90	5	b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 PRUNE2 MYO9A LRRK2 PPM1H	3.50e-05	183	90	5	738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SFTPA2 CFAP221 LRRK2 SFTPA1 CCDC141	3.50e-05	183	90	5	6847c1252d6bb105524f812658112517fd351eab
ToppCell	COPD-Epithelial-ATII\|World / Disease state, Lineage and Cell class	SFTPA2 SYNE1 LRRK2 SFTPA1 CCDC141	3.50e-05	183	90	5	8e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 MYO9A SYNE1 CFAP221 PPM1H	3.50e-05	183	90	5	cfae90c309622b5d499e62a3a8a8b9746478d28d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 PRUNE2 MYO9A LRRK2 PPM1H	3.50e-05	183	90	5	92fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Rorb-Excitatory_Neuron.Slc17a7-Slc17a6.Rorb-Pcdh20_(Layer_5a)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	WHRN CFAP221 RORB ADGRF4	3.50e-05	91	90	4	1fa597c5fa4523b18fa386ee19237b82778bb1cb
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	SFTPA2 CFAP221 LRRK2 SFTPA1 CCDC141	3.59e-05	184	90	5	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 MYO9A CFAP221 LRRK2 PPM1H	3.59e-05	184	90	5	da06ff24ee2b2cf4715fdfce43030b2da9e0aaf8
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ASGR1 SYNE1 LAMA4 ZFPM2 KLHL4	3.59e-05	184	90	5	453295362888c9a59d0e73c7a5b15914c50ff591
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LAMA4 SLITRK6 UNC80 ZFPM2 BGN	3.69e-05	185	90	5	9f19f04fc4d97dfc2dd78cde77b515f1cb5d51ec
ToppCell	droplet-Lung-LUNG-30m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA4 NBEA ZFPM2 ATL1 KLHL4	3.78e-05	186	90	5	f23f21781a758541f59c06efa7739d26a03fb478
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 MYO9A CFAP221 LRRK2 PPM1H	3.78e-05	186	90	5	3dae539cce15fcf2b1b32e981d7febe94c03c600
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA4 NBEA ZFPM2 ATL1 KLHL4	3.78e-05	186	90	5	0de87109da9324c597fadf2eb782f0f158afe832
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	LAMA4 SLITRK6 UNC80 ZFPM2 BGN	3.88e-05	187	90	5	13731298bc562ec29582f5da1b4c97261284f6f1
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYO9A CFAP221 LRRK2 PPM1H	3.88e-05	187	90	5	c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYO9A CFAP221 LRRK2 PPM1H	3.98e-05	188	90	5	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 PRUNE2 MYO9A LRRK2 PPM1H	4.08e-05	189	90	5	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRUNE2 SYNE1 NTRK3 ZFPM2 BGN	4.08e-05	189	90	5	7ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 MYO9A CFAP221 LRRK2 PPM1H	4.08e-05	189	90	5	1ecf9911ff82e0ca0f0c101b735d3b1f3b339d57
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 TRIO LAMA4 ACTN4 PPM1H	4.08e-05	189	90	5	8c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FSD1L RAPGEF3 LAMA4 ZFPM2 BGN	4.08e-05	189	90	5	ce5b3d53c9a5457a5a02b221dee18334b5eaf8b7
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 TRIO LAMA4 ACTN4 PPM1H	4.08e-05	189	90	5	5d902a4660a27548764bf04c6de152b565da835c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 PRUNE2 MYO9A LRRK2 TFAP2C	4.08e-05	189	90	5	bd91bdfe35294e60d980259b70fe9e60dca2743f
ToppCell	COVID-19-lung-AT2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SFTPA2 CFAP221 LRRK2 SFTPA1 CCDC141	4.19e-05	190	90	5	27a1a86620fe9b5ee930d388b32352206485e6d0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYO9A SYNE1 CFAP221 LRRK2 PPM1H	4.19e-05	190	90	5	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NEDD9 SYNE1 GOLIM4 RORB ACTN4	4.29e-05	191	90	5	04faa7d2237e45418611153294eb6f7bb690cbde
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SFTPA2 CFAP221 LRRK2 SFTPA1 CCDC141	4.29e-05	191	90	5	a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	SFTPA2 CFAP221 LRRK2 SFTPA1 CCDC141	4.29e-05	191	90	5	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRUNE2 SYNE1 NTRK3 ZFPM2 BGN	4.29e-05	191	90	5	08042952431ca1a6fd7dfc13f36eb28643979598
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	NEDD9 ARHGEF28 AKAP9 GREB1 PUM1	4.40e-05	192	90	5	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	SFTPA2 CFAP221 LRRK2 SFTPA1 CCDC141	4.40e-05	192	90	5	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	SFTPA2 CFAP221 LRRK2 SFTPA1 CCDC141	4.40e-05	192	90	5	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	AKAP9 USP9X PUM1 TRIP11 ZNF260	4.51e-05	193	90	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2\|Adult / Lineage, Cell type, age group and donor	SFTPA2 CFAP221 LRRK2 SFTPA1 CCDC141	4.51e-05	193	90	5	738f4f0a9ddde2432b429ab46838e353b1790589
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GLI3 NTRK3 LAMA4 ZFPM2 BGN	4.51e-05	193	90	5	5de87fc94a6e58899ef4124cf4887ed3ff96163a
ToppCell	cellseq2-Epithelial-Epithelial_Alveolar-AT2-AT2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SFTPA2 MYO9A FBF1 LRRK2 SFTPA1	4.62e-05	194	90	5	df835578d86a49ae5af5632152fbab9548c0a448
ToppCell	cellseq2-Epithelial-Epithelial_Alveolar\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SFTPA2 MYO9A FBF1 LRRK2 SFTPA1	4.62e-05	194	90	5	0715f2d55f4a6d2edda1b3dc52f12d25ce59eb10
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TRIO SACS NADK2 GOLIM4 KLHL4	4.62e-05	194	90	5	8b81f039f5b25d35a4d5a41b27d4d9360ba22f15
ToppCell	cellseq2-Epithelial-Epithelial_Alveolar-AT2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SFTPA2 MYO9A FBF1 LRRK2 SFTPA1	4.62e-05	194	90	5	a4f7cd507eba40985d82635bbae28c7f5703f883
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	WHRN TRIO CFAP221 ELFN2 PPM1H	4.74e-05	195	90	5	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	Control-Multiplet\|Control / Disease state, Lineage and Cell class	SFTPA2 SYNE1 CFAP221 SFTPA1 CTTN	4.74e-05	195	90	5	618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCell	AT2_cells-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	SFTPA2 SYNE1 LRRK2 SFTPA1 CCDC141	4.74e-05	195	90	5	0792c1e959e933b10ae987d821ff43020dfdabad
ToppCell	AT2_cells-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	SFTPA2 LRRK2 SFTPA1 RORB CCDC141	4.74e-05	195	90	5	33f60762f00cd6f4757d8a8d5227141558ac823e
ToppCell	AT2_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	SFTPA2 SYNE1 LRRK2 SFTPA1 CCDC141	4.74e-05	195	90	5	b0cea3f4e59635913d243612f2e8cf4c7b34e726
ToppCell	343B\|World / Donor, Lineage, Cell class and subclass (all cells)	SFTPA2 CFAP221 LRRK2 SFTPA1 RORB	4.74e-05	195	90	5	2290911fde6efacfa38b985a2541322968bee42d
Drug	Sulfamerazine [127-79-7]; Up 200; 15.2uM; MCF7; HT_HG-U133A	RNF32 WHRN TRIO GREB1 ST8SIA3 CEP164 WDR62	1.33e-05	197	90	7	3616_UP
Drug	Oxantel pamoate [68813-55-8]; Down 200; 6.6uM; PC3; HT_HG-U133A	WHRN TRIO DDX60 ST8SIA3 TFAP2C TAFAZZIN WDR62	1.37e-05	198	90	7	6738_DN
Drug	Suxibuzone [27470-51-5]; Up 200; 9.2uM; MCF7; HT_HG-U133A	PRUNE2 AKAP9 HDAC4 CALCOCO1 LAMA4 EEA1 ST8SIA3	1.42e-05	199	90	7	7163_UP
Drug	Enilconazole [35554-44-0]; Up 200; 13.4uM; MCF7; HT_HG-U133A	ADCY10 MAN2A2 ADAM20 CALCOCO1 LAMA4 GREB1 WDR62	1.47e-05	200	90	7	6518_UP
Disease	hereditary spastic paraplegia 3A (implicated_via_orthology)	ATL2 ATL1	2.51e-05	3	86	2	DOID:0110791 (implicated_via_orthology)
Disease	Intellectual Disability	HDAC4 TRIO SACS SYNE1 NBEA PUM1 ATL1 WDR62	4.92e-05	447	86	8	C3714756
Disease	level of leukocyte immunoglobulin-like receptor subfamily B member 4 in blood serum	SFTPA2 SFTPA1	8.35e-05	5	86	2	OBA_2042200
Disease	level of prosaposin in blood serum	SFTPA2 SFTPA1	8.35e-05	5	86	2	OBA_2044552
Disease	newborn respiratory distress syndrome (biomarker_via_orthology)	SFTPA2 SFTPA1	1.25e-04	6	86	2	DOID:12716 (biomarker_via_orthology)
Disease	newborn respiratory distress syndrome (is_implicated_in)	SFTPA2 SFTPA1	1.75e-04	7	86	2	DOID:12716 (is_implicated_in)
Disease	attention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia	HDAC4 SYNE1 NTRK3 ZFPM2	2.21e-04	101	86	4	EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
Disease	leukocyte immunoglobulin-like receptor subfamily B member 4 measurement	SFTPA2 SFTPA1	2.32e-04	8	86	2	EFO_0801768
Disease	Dickkopf-related protein 4 measurement	CEP112 ZFPM2	2.32e-04	8	86	2	EFO_0008110
Disease	chronic obstructive pulmonary disease, chronic bronchitis	CFAP221 CRACR2B	3.72e-04	10	86	2	EFO_0000341, EFO_0006505
Disease	complement C1q tumor necrosis factor-related protein 1 measurement	SFTPA2 SFTPA1	5.44e-04	12	86	2	EFO_0801493
Disease	Renal dysplasia and retinal aplasia (disorder)	IQCB1 CEP164	5.44e-04	12	86	2	C0403553
Disease	granulins measurement	SFTPA2 SFTPA1	5.44e-04	12	86	2	EFO_0008141
Disease	Hamman-Rich syndrome	SFTPA2 SFTPA1	7.47e-04	14	86	2	C0085786
Disease	bacterial pneumonia (biomarker_via_orthology)	SFTPA2 SFTPA1	7.47e-04	14	86	2	DOID:874 (biomarker_via_orthology)
Disease	Endometrioma	NTRK3 LRRK2 RORB GREB1	1.28e-03	161	86	4	C0269102
Disease	Endometriosis	NTRK3 LRRK2 RORB GREB1	1.28e-03	161	86	4	C0014175
Disease	Familial Idiopathic Pulmonary Fibrosis	SFTPA2 SFTPA1	1.54e-03	20	86	2	C4721952
Disease	cup-to-disc ratio measurement	NEDD9 RAPGEF3 GLI3 ACTN4 CCDC171 ELFN2	1.63e-03	430	86	6	EFO_0006939
Disease	Idiopathic Pulmonary Fibrosis	SFTPA2 SFTPA1	1.70e-03	21	86	2	C1800706
Disease	severe acute respiratory syndrome, COVID-19	ARHGEF28 USP9X APOL4 SLFN5 ZFPM2 KLHL4	1.98e-03	447	86	6	EFO_0000694, MONDO_0100096
Disease	Ovarian Serous Adenocarcinoma	TRPM7 LRRK2	2.04e-03	23	86	2	C1335177
Disease	congenital diaphragmatic hernia (biomarker_via_orthology)	SFTPA2 SFTPA1	2.22e-03	24	86	2	DOID:3827 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QDLQHLDNEESDHHQ	ASGR1	6	P07306
LTHQQQLEEQDHLLE	AKAP9	271	Q99996
SNTEFLQVIEIHNHQ	ABRAXAS2	46	Q15018
EVQNVDDQHLLLHDQ	TFAP2C	176	Q92754
LEHHQLSQFQLLEQE	NEDD9	661	Q14511
NLNNRLQHDVAHLFI	ADAM20	286	O43506
AQELEENLNELTHIH	APOL4	331	Q9BPW4
LNHIEKSHEQLVLEN	CCDC171	696	Q6TFL3
HIHNNSENIVNELFI	ADGRF4	226	Q8IZF3
HQLIQEALIFDNKHT	ACTN4	711	O43707
LEHEQEKTHLLQQHN	CEP112	666	Q8N8E3
HTRLQNEHVKLQNEL	CEP83	56	Q9Y592
QLLEQHQVSDLTDFH	DNHD1	1586	Q96M86
LKNLEHHEVLVFQQT	ADCY10	741	Q96PN6
LEIKNNHLNQAIHEE	RALBP1	566	Q15311
NHLNQAIHEEREAII	RALBP1	571	Q15311
EHLEAASHQNQQLET	GOLGA6A	476	Q9NYA3
LEELHQHTEQLVQDQ	PUM2	906	Q8TB72
RILSLQNHHIIENNH	PARP9	536	Q8IXQ6
EKEVHDQLLQLHSIQ	GOPC	116	Q9HD26
DRQHEELANVHQLQH	ARHGEF28	1431	Q8N1W1
FDTQEQLVHHINNDH	GLI3	491	P10071
QHEQLSRQHEAQLHE	HDAC4	96	P56524
HVHNFIILNVDLTQN	GREB1	1716	Q4ZG55
QREAELLTNLQHEHI	NTRK3	586	Q16288
HLQELNLNDNHLESF	LRR1	201	Q96L50
VDLHEQQLSLNQHNR	NADK2	236	Q4G0N4
EAQLEHAELQEQLHR	FYCO1	886	Q9BQS8
NDEIQNFIDTLHHTL	FSD1L	51	Q9BXM9
GFQTQRELLQHQELH	ZFPM2	371	Q8WW38
NVDQSLIHEAEHDNL	DDX60	1196	Q8IY21
ALILHLQHNTNIDVQ	DDX60L	106	Q5H9U9
LEEENHHLLSQIQLL	CCDC88C	1331	Q9P219
LNELHLDHNKIQAIE	BGN	231	P21810
QLQLDENELPHAVHF	LRRK2	1561	Q5S007
NVQVDHLNLLKQFEH	NUCB1	126	Q02818
LQQHNLIVHFQANED	KLHL4	91	Q9C0H6
LEELHQHTEQLVQDQ	PUM1	1026	Q14671
QQHKNLLSEHEQLVV	GOLIM4	201	O00461
QAFVEELQFLQSHHL	OBSCN	5706	Q5VST9
LHQQESQSLQLHFRV	ITGA5	926	P08648
EQHGLQLQSEINQLH	EEA1	406	Q15075
ENLHDQVQEQKAHLR	EEA1	596	Q15075
QQHQADLELIESAHR	FBF1	616	Q8TES7
NVQEDDLQHLQLFTE	ATL1	181	Q8WXF7
HLQLSHQKLSQLQEE	CCDC141	326	Q6ZP82
QNEKTQLQAHLDHLI	CCDC150	411	Q8NCX0
QLQAHLDHLILEHNQ	CCDC150	416	Q8NCX0
RELEQQLHAQAAEHL	CRACR2B	261	Q8N4Y2
QLHAQAAEHLEAQAQ	CRACR2B	266	Q8N4Y2
SQNIQEDDLQHLQLF	ATL2	206	Q8NHH9
QLEQLLEENHEIISH	MAN2A2	56	P49641
HVELIQNVLQSDHFL	IQCB1	156	Q15051
QNVLQSDHFLHLLQA	IQCB1	161	Q15051
SDHFLHLLQADNVQI	IQCB1	166	Q15051
LQNTVDILLHHIFQE	SACS	3621	Q9NZJ4
DEEVREFLHNNLHLQ	RYR1	3546	P21817
LQVAQQENHHLNLDL	CALCOCO1	286	Q9P1Z2
LFLEHAHNLADNVQS	CEBPG	121	P53567
QEQHSQELLAELLTH	TBRG4	196	Q969Z0
QHVQLLFDNEVLPDH	PCGF1	216	Q9BSM1
NLSHDLVQEAIDHAQ	LAMA4	581	Q16363
HQQILHLVNVSNEDT	CFAP221	76	Q4G0U5
DLINQLQHNHALVTL	USP9X	601	Q93008
EHLQANQHLANIVER	TRIM34	66	Q9BYJ4
HIFRDEINLHQLNDE	PRUNE2	86	Q8WUY3
QLHINHNSLEILKED	SLITRK6	116	Q9H5Y7
ENLFEAQQLLLHHQQ	SYNE1	1266	Q8NF91
FNQLEDELNSHEHEL	SYNE1	2021	Q8NF91
HKEDLEQHSRQLQEQ	TMEM191B	136	P0C7N4
NSNENIIFVHNTIHL	NBEA	1371	Q8NFP9
HLLNSEHLATQAEQQ	PHF12	416	Q96QT6
VNAVALQDHILHDLQ	RNF32	16	Q9H0A6
AFLHQRQEILQHVDV	ST8SIA3	96	O43173
LEEQARHLLNEQEHA	WHRN	426	Q9P202
ELQATLHDFRHQILQ	SFTPA2	106	Q8IWL1
ELQATLHDFRHQILQ	SFTPA1	106	Q8IWL2
EHTHLLQSNQQLREI	CEP164	986	Q9UPV0
HEGNHTLVENLINFE	RAPGEF3	826	O95398
LLHHQKIQTLDQNVE	ZNF157	121	P51786
TLQHEKIQTLDHNFE	ZNF33B	206	Q06732
NHEELSARQHIADQL	UNC80	2866	Q8N2C7
ESLQHESDLLQHDQI	ZNF260	6	Q3ZCT1
QEEFQHLKTQAEQLH	TAFAZZIN	241	Q16635
LQHHITEQLQDIVDI	PPM1H	166	Q9ULR3
EHINIHKLRENVFQE	CTTN	51	Q14247
FALQHVIQKNHLDDE	RORB	401	Q92753
LLEIDHRQQQQHTND	WDR62	756	O43379
LKQNRSQEIDDHQHE	TRIP11	221	Q15643
QHESAQLQEELHQLQ	TRIP11	1236	Q15643
ENLNLENHRDQELLH	ZNF18	296	P17022
IQAQLEQHDIHNAKL	TXLNG	251	Q9NUQ3
EQHDIHNAKLRQENI	TXLNG	256	Q9NUQ3
EHIQHIIIDDAQNFR	SLFN5	641	Q08AF3
NVLNNLHSHFILVDD	TRPM7	236	Q96QT4
NVLFHSLLNLAQEDH	TEX38	181	Q6PEX7
QEAEQLQREHEQFQH	TRIO	941	O75962
QHINSTVHDLRLNEN	ELFN2	51	Q5R3F8
QERQHLQDLLHQEVL	MYO9A	1006	B2RTY4