Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenodecreased liver glycogen level

NCOR1 MARK3 PCK1

3.18e-0549183MP:0010398
MousePhenoabnormal Ly6C-positive NK T cell number

UBE3C RHOBTB1

4.36e-058182MP:0013677
MousePhenodecreased glycogen level

NCOR1 MARK3 PCK1

7.45e-0565183MP:0005439
MousePhenoincreased cardiac muscle contractility

RAF1 TBX3 UBE3C

8.91e-0569183MP:0005599
MousePhenoabnormal liver glycogen level

NCOR1 MARK3 PCK1

1.44e-0481183MP:0012777
MousePhenolethality throughout fetal growth and development, complete penetrance

VEZF1 RAF1 NCOR1 TBX3

3.04e-04263184MP:0011099
DomainBTB

KBTBD3 RHOBTB1

8.54e-03131202PF00651
DomainBTB

KBTBD3 RHOBTB1

1.25e-02160202PS50097
Pubmed

C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1.

RAF1 MARK3

2.08e-06421211741534
Pubmed

TBX3 acts as tissue-specific component of the Wnt/β-catenin transcriptional complex.

BCL9L TBX3

3.47e-06521232808927
Pubmed

A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.

NCOR1 RHOBTB1

9.70e-06821222157079
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

CUL9 NCOR1 TBX3 INTS14

2.27e-0528221423667531
Pubmed

Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1, Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal imprinting region of mouse chromosome 2 are not monoallelically expressed.

CDH4 PCK1

3.15e-05142127781998
Pubmed

A protein interaction landscape of breast cancer.

RAF1 CUL9 TBX3 SPTBN2 UBE3C

3.17e-0563421534591612
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

PTPRF CUL9 NEURL4 UBE3C

3.41e-0531321438270169
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CUL9 FKBP15 MARK3 UBE3C

9.45e-0540721412693553
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

VEZF1 KBTBD3 NCOR1 HSPBAP1 TBX3

9.98e-0580821520412781
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

RAF1 BCL9L FKBP15

1.03e-0415221334299191
Pubmed

Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal.

RAF1 PCK1

1.12e-04262127905852
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

RAF1 BCL9L FKBP15 MARK3

1.34e-0444621424255178
Pubmed

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.

RAF1 MARK3

1.50e-043021216306228
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

CUL9 NEURL4 UBE3C

2.74e-0421221333853758
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

PTPRF RAF1 MARK3 SPTBN2

3.40e-0456921430639242
Pubmed

Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

RAF1 NCOR1 PCK1

4.44e-0425021318660489
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

RAF1 CUL9 TBX3 INTS14 RTL9

4.47e-04111621531753913
Pubmed

Skp2-Mediated Stabilization of MTH1 Promotes Survival of Melanoma Cells upon Oxidative Stress.

BCL9L HSPBAP1

4.52e-045221228947420
Pubmed

Claudin-4 localization in epithelial ovarian cancer.

MARK3 SPTBN2

4.88e-045421236237976
Pubmed

Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.

NEURL4 UBE3C

5.62e-045821222645313
InteractionCST5 interactions

FKBP15 PCK1 RHOBTB1

6.81e-0636213int:CST5
GeneFamilyBasic leucine zipper proteins|BTB domain containing

KBTBD3 RHOBTB1

4.03e-03134132861
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

FKBP15 NCOR1

7.23e-03181132694
ToppCellE16.5-samps-Mesenchymal-Myofibroblast-Smooth_Muscle-like_MyoFibroblast|E16.5-samps / Age Group, Lineage, Cell class and subclass

CDH4 SPTBN2 RTL9

3.76e-051402135623a0a68403fc00166b7d13d13e184a718d9bdd
ToppCellCOVID-19-Heart-Adipocyte|Heart / Disease (COVID-19 only), tissue and cell type

PTPRF CDH4 PCK1

6.59e-05169213bd39f85b48207955f80ca120a11e15a0124117b9
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRF TBX3 SPTBN2

9.62e-051922139e031bf93eb8757fdd0cc22f01b44e48f85532d5
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRF TBX3 SPTBN2

9.62e-051922133d777d07878269b87ec7e1f06489cae7c989d633
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRF TBX3 SPTBN2

9.62e-05192213d5ec4cdb15620a5abfc83577353501186c2bc86a
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRF TBX3 SPTBN2

9.76e-051932135da60321bcf761913eb30779b6d8b1e933c5e51e
ToppCelldroplet-Pancreas-Endocrine-21m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRF NCOR1 RHOBTB1

9.91e-051942133a3ecedcdc7691cf21775818b598208fcb980c29
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRF NCOR1 RHOBTB1

9.91e-051942130b023de48ed8a550d169bbe954881eb04bf4f981
DiseaseBreast adenocarcinoma

NCOR1 TBX3

3.89e-0441212C0858252
DiseaseNeoplasm of uncertain or unknown behavior of breast

NCOR1 TBX3

3.89e-0441212C0496956
DiseaseMalignant mesothelioma

PTPRF RAF1

2.71e-03109212C0345967
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Positive

UBE3C RHOBTB1

3.89e-03131212C4704862
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Negative

UBE3C RHOBTB1

3.89e-03131212C4552091
DiseaseJuvenile arthritis

UBE3C RHOBTB1

3.89e-03131212C3495559
DiseaseJuvenile psoriatic arthritis

UBE3C RHOBTB1

3.89e-03131212C3714758
DiseaseJuvenile-Onset Still Disease

UBE3C RHOBTB1

4.12e-03135212C0087031
DiseaseMalignant neoplasm of liver

RAF1 NCOR1

4.55e-03142212C0345904
DiseaseLiver neoplasms

RAF1 NCOR1

4.55e-03142212C0023903
Diseasemajor depressive disorder

MARK3 SPTBN2

5.39e-03155212MONDO_0002009
DiseaseMammary Neoplasms, Human

RAF1 NCOR1 TBX3

5.87e-03525213C1257931
DiseaseMammary Carcinoma, Human

RAF1 NCOR1 TBX3

5.87e-03525213C4704874
DiseaseMammary Neoplasms

RAF1 NCOR1 TBX3

5.93e-03527213C1458155
DiseaseBreast Carcinoma

RAF1 NCOR1 TBX3

6.28e-03538213C0678222
Diseasecortical thickness

PTPRF CUL9 MARK3 SPTBN2

7.21e-031113214EFO_0004840

Protein segments in the cluster

PeptideGeneStartEntry
SLTMRRMRESVSRMP

RAF1

211

P04049
VVASMRIMTRMGTPV

PCK1

166

P35558
VSTMKTPRTMHTSVM

KBTBD3

386

Q8NAB2
IPSMSVTMETSMIMS

FKBP15

551

Q5T1M5
QIRFRMGMKSMSTVP

HSPBAP1

71

Q96EW2
MPTVVVMDVSLSMTR

INTS14

1

Q96SY0
SMPMSNVGTTRLSHM

BCL9L

876

Q86UU0
SIDSMSGRMYVTRPM

CDH4

221

P55283
TTSSMDPGDMMREIR

MARK3

666

P27448
RTEPMPTTRTILMML

CUL9

906

Q8IWT3
PSTMTNLRSGTWMMT

NEURL4

596

Q96JN8
PGRPTMMISTTAMNT

PTPRF

821

P10586
TPQVMLGMSMAVTIR

OR52I1

141

Q8NGK6
AMTTSLMTVPSSGVM

RTL9

436

Q8NET4
MTATDSRGMSTPLMR

RTL9

1061

Q8NET4
MSLSMRDPVIPGTSM

TBX3

1

O15119
TMSRGSPMMNRTSDV

NCOR1

1491

O75376
SKRMGPMTVVRMDAS

RHOBTB1

391

O94844
TMSNPVTVAAAMSMR

VEZF1

411

Q14119
VVPSTTRGMTRAMTM

SPTBN2

2341

O15020
MVVMRTNPTLAESMR

SYCE3

46

A1L190
MSTRMITGSMVPLLQ

UBE3C

466

Q15386