Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	actin binding	XIRP1 PHACTR2 SPATA31A3 WIPF1 MAP1A INPPL1 SPATA31A7 SPATA31A6 SPATA31A5 MRTFB SPATA31A1 MICALL2 NF2 LIMCH1 NOS3	1.07e-07	479	115	15	GO:0003779
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	SH3RF1 NRBF2 ATN1 MAP1A NAB2 PEX6 ICE1 DRAP1 SRCAP PPP1R13L RCOR2 NCOR2 KMT2D MRTFB LAT SETD5 INSM2 IRS2 DGCR8 NOTCH1	9.64e-06	1160	115	20	GO:0030674
GeneOntologyMolecularFunction	transcription coregulator activity	NRBF2 ATN1 NAB2 DRAP1 SRCAP PPP1R13L RCOR2 NCOR2 KMT2D MRTFB SETD5 INSM2 NOTCH1	2.15e-05	562	115	13	GO:0003712
GeneOntologyMolecularFunction	molecular adaptor activity	SH3RF1 NRBF2 ATN1 MAP1A NAB2 PEX6 ICE1 DRAP1 SRCAP PPP1R13L RCOR2 NCOR2 KMT2D MRTFB LAT SETD5 ITSN2 INSM2 IRS2 DGCR8 NOTCH1	2.82e-05	1356	115	21	GO:0060090
GeneOntologyMolecularFunction	transcription corepressor activity	ATN1 NAB2 DRAP1 PPP1R13L RCOR2 NCOR2 SETD5 INSM2	5.46e-05	229	115	8	GO:0003714
GeneOntologyMolecularFunction	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	INPP5E INPPL1	6.78e-04	7	115	2	GO:0034485
GeneOntologyMolecularFunction	inositol-polyphosphate 5-phosphatase activity	INPP5E INPPL1	9.00e-04	8	115	2	GO:0004445
GeneOntologyCellularComponent	ribonuclease III complex	DROSHA DGCR8	8.97e-05	3	115	2	GO:1903095
GeneOntologyCellularComponent	TCR signalosome	LCP2 LAT	8.97e-05	3	115	2	GO:0036398
GeneOntologyCellularComponent	microprocessor complex	DROSHA DGCR8	8.97e-05	3	115	2	GO:0070877
GeneOntologyCellularComponent	histone deacetylase complex	SRCAP RCOR2 PHF21A NCOR2 SETD5	1.07e-04	85	115	5	GO:0000118
GeneOntologyCellularComponent	acrosomal vesicle	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1 CFAP119 NOTCH1	1.45e-04	206	115	7	GO:0001669
GeneOntologyCellularComponent	nuclear protein-containing complex	POLR3GL ZCCHC8 SCAF8 HLF ICE1 DRAP1 KDM6B SRCAP RCOR2 PHF21A NCOR2 KMT2D LAT SETD5 DROSHA DGCR8 CDC23 SYMPK	5.15e-04	1377	115	18	GO:0140513
MousePheno	abnormal eye development	ATN1 NTF4 INPP5E NR6A1 PPP1R13L SOCS7 COL18A1 NCOR2 ZNRF3 SETD5 ARHGAP44 LPP LRP5 IRS2 ADAMTSL4	2.50e-07	482	87	15	MP:0001286
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31D4 SPATA31D1 SPATA31D3	2.02e-13	12	114	7	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31D4 SPATA31D1 SPATA31D3	2.02e-13	12	114	7	IPR027970
Domain	NPIP	NPIPB15 NPIPB9 NPIPB8	7.68e-05	14	114	3	IPR009443
Domain	DUF2476	PRR23B PRR23C	2.20e-04	4	114	2	PF10630
Domain	Mod_r	VPS37B VPS37D	2.20e-04	4	114	2	PF07200
Domain	Mod_r	VPS37B VPS37D	2.20e-04	4	114	2	IPR009851
Domain	PRR23	PRR23B PRR23C	2.20e-04	4	114	2	IPR018903
Domain	VPS37_C	VPS37B VPS37D	2.20e-04	4	114	2	PS51314
Domain	GAE	GGA3 GGA1	3.65e-04	5	114	2	PS50180
Domain	-	SCAF8 GGA3 GGA1	5.20e-04	26	114	3	1.25.40.90
Domain	-	GGA3 GGA1	5.45e-04	6	114	2	2.60.40.1230
Domain	GAT_dom	GGA3 GGA1	5.45e-04	6	114	2	IPR004152
Domain	-	GGA3 GGA1	5.45e-04	6	114	2	1.20.58.160
Domain	Clathrin_g-adaptin_app	GGA3 GGA1	5.45e-04	6	114	2	IPR008153
Domain	GAT	GGA3 GGA1	5.45e-04	6	114	2	PS50909
Domain	GAT	GGA3 GGA1	5.45e-04	6	114	2	PF03127
Domain	ENTH_VHS	SCAF8 GGA3 GGA1	7.21e-04	29	114	3	IPR008942
Domain	RPEL	PHACTR2 MRTFB	7.60e-04	7	114	2	PS51073
Domain	RPEL	PHACTR2 MRTFB	7.60e-04	7	114	2	SM00707
Domain	RPEL	PHACTR2 MRTFB	7.60e-04	7	114	2	PF02755
Domain	RPEL_repeat	PHACTR2 MRTFB	7.60e-04	7	114	2	IPR004018
Domain	Alpha_adaptinC2	GGA3 GGA1	1.29e-03	9	114	2	PF02883
Domain	VHS	GGA3 GGA1	1.29e-03	9	114	2	PS50179
Domain	Clathrin_a/b/g-adaptin_app_Ig	GGA3 GGA1	1.29e-03	9	114	2	IPR008152
Domain	VHS	GGA3 GGA1	1.29e-03	9	114	2	PF00790
Domain	Alpha_adaptinC2	GGA3 GGA1	1.29e-03	9	114	2	SM00809
Domain	VHS	GGA3 GGA1	1.29e-03	9	114	2	SM00288
Domain	VHS_dom	GGA3 GGA1	1.29e-03	9	114	2	IPR002014
Domain	MYB_LIKE	RCOR2 NCOR2 MYPOP	1.60e-03	38	114	3	PS50090
Domain	IPPc	INPP5E INPPL1	1.61e-03	10	114	2	IPR000300
Domain	IPPc	INPP5E INPPL1	1.61e-03	10	114	2	SM00128
Domain	MBD	BAZ2B MBD6	1.96e-03	11	114	2	SM00391
Domain	MBD	BAZ2B MBD6	1.96e-03	11	114	2	PS50982
Domain	Methyl_CpG_DNA-bd	BAZ2B MBD6	1.96e-03	11	114	2	IPR001739
Domain	MBD	BAZ2B MBD6	1.96e-03	11	114	2	PF01429
Domain	DNA-bd_dom	BAZ2B MBD6	1.96e-03	11	114	2	IPR016177
Domain	Coatomer/clathrin_app_Ig-like	GGA3 GGA1	2.34e-03	12	114	2	IPR013041
Domain	SANT	RCOR2 NCOR2 MYPOP	3.52e-03	50	114	3	SM00717
Domain	SANT/Myb	RCOR2 NCOR2 MYPOP	3.94e-03	52	114	3	IPR001005
Domain	DSRM	DROSHA DGCR8	5.90e-03	19	114	2	SM00358
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA6C SH3RF1 INPP5E INPPL1 PEX6 ICE1 PLXND1 KDM6B SRCAP MBD6 GGA3 HIVEP3 NHSL1 NCOR2 KMT2D SLC2A4RG NF2 ZNRF3 SETD5 ARHGAP44 LRP5 POLL IRS2 GGA1 NOTCH1 SYMPK	9.24e-15	1105	121	26	35748872
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1	2.81e-12	6	121	5	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1	2.81e-12	6	121	5	25930072
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1	1.89e-08	24	121	5	32212159
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	WIPF1 INPPL1 VPS37B LIMCH1 PRRC2A CDC23	2.24e-06	108	121	6	19531213
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	ATN1 MAP1A INPPL1 VPS37B GGA3 NCOR2 MRTFB UBQLN3 NOTCH1 CRTC2	2.81e-06	430	121	10	35044719
Pubmed	Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer.	NF2 DROSHA DGCR8	3.40e-06	9	121	3	24581491
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	PHACTR2 SH3RF1 INPPL1 PPP1R13L GGA3 NHSL1 MRTFB NF2 LPP LIMCH1 NOTCH1	4.82e-06	565	121	11	25468996
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	CTU2 XIRP1 CNOT11 SH3RF1 INPPL1 NHSL1 KANK1 DENND4B SKOR2 LPP SEZ6 SYMPK	5.44e-06	689	121	12	36543142
Pubmed	A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome.	MAP1A GGA3 GGA1	6.64e-06	11	121	3	10747088
Pubmed	Functional proteomics mapping of a human signaling pathway.	ZCCHC8 PEX6 PPP1R13L GGA3 NCOR2 KANK1 KMT2D MRTFB DROSHA LRP5 GGA1	7.36e-06	591	121	11	15231748
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PHACTR2 SH3RF1 ZCCHC8 INPP5E INPPL1 NHSL1 FAM171A2 LPP IRS2 LIMCH1 PAN3 CSPP1 CRTC2	1.01e-05	861	121	13	36931259
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	NYAP2 SH3RF1 PPP1R13L NHSL1 MICALL2 LPP DZIP3	1.19e-05	218	121	7	33378226
Pubmed	Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.	NOS3 NOTCH1	1.20e-05	2	121	2	23583836
Pubmed	Posttranscriptional crossregulation between Drosha and DGCR8.	DROSHA DGCR8	1.20e-05	2	121	2	19135890
Pubmed	Cutting edge: rescue of pre-TCR but not mature TCR signaling in mice expressing membrane-targeted SLP-76.	LCP2 LAT	1.20e-05	2	121	2	19380761
Pubmed	The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis.	DROSHA DGCR8	1.20e-05	2	121	2	15589161
Pubmed	Evaluation of polymorphisms in microRNA biosynthesis genes and risk of laryngeal cancer in the Polish population.	DROSHA DGCR8	1.20e-05	2	121	2	28155978
Pubmed	The Microprocessor complex mediates the genesis of microRNAs.	DROSHA DGCR8	1.20e-05	2	121	2	15531877
Pubmed	Functional Anatomy of the Human Microprocessor.	DROSHA DGCR8	1.20e-05	2	121	2	26027739
Pubmed	DGCR8 HITS-CLIP reveals novel functions for the Microprocessor.	DROSHA DGCR8	1.20e-05	2	121	2	22796965
Pubmed	The Drosha-DGCR8 complex in primary microRNA processing.	DROSHA DGCR8	1.20e-05	2	121	2	15574589
Pubmed	Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor.	DROSHA DGCR8	1.20e-05	2	121	2	32317642
Pubmed	Pharmacogenetic angiogenesis profiling for first-line chemotherapy in patients with advanced gastric cancer.	COL18A1 NOS3	1.20e-05	2	121	2	23641912
Pubmed	Association of miRNA biosynthesis genes DROSHA and DGCR8 polymorphisms with cancer susceptibility: a systematic review and meta-analysis.	DROSHA DGCR8	1.20e-05	2	121	2	29654164
Pubmed	Inflammation induced changes in the expression levels of components of the microRNA maturation machinery Drosha, Dicer, Drosha co-factor DGRC8 and Exportin-5 in inflammatory lesions of hidradenitis suppurativa patients.	DROSHA DGCR8	1.20e-05	2	121	2	26917346
Pubmed	Global miRNA dosage control of embryonic germ layer specification.	DROSHA DGCR8	1.20e-05	2	121	2	33953397
Pubmed	Cellular functions of the microprocessor.	DROSHA DGCR8	1.20e-05	2	121	2	23863141
Pubmed	The role of SLP-76 and LAT in lymphocyte development.	LCP2 LAT	1.20e-05	2	121	2	10712938
Pubmed	Metalloprotease-disintegrin ADAM12 expression is regulated by Notch signaling via microRNA-29.	ADAM12 NOTCH1	1.20e-05	2	121	2	21518768
Pubmed	A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes.	NOS3 NOTCH1	1.20e-05	2	121	2	34504875
Pubmed	Genomic Clustering Facilitates Nuclear Processing of Suboptimal Pri-miRNA Loci.	DROSHA DGCR8	1.20e-05	2	121	2	32302542
Pubmed	Genomic analysis suggests that mRNA destabilization by the microprocessor is specialized for the auto-regulation of Dgcr8.	DROSHA DGCR8	1.20e-05	2	121	2	19759829
Pubmed	Commutative regulation between endothelial NO synthase and insulin receptor substrate 2 by microRNAs.	IRS2 NOS3	1.20e-05	2	121	2	30295821
Pubmed	Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs.	DROSHA DGCR8	1.20e-05	2	121	2	29170488
Pubmed	Oxidative-mechanical stress signals stem cell niche mediated Lrp5 osteogenesis in eNOS(-/-) null mice.	LRP5 NOS3	1.20e-05	2	121	2	22359381
Pubmed	Schizophrenia is associated with an increase in cortical microRNA biogenesis.	DROSHA DGCR8	1.20e-05	2	121	2	19721432
Pubmed	The internal loops in the lower stem of primary microRNA transcripts facilitate single cleavage of human Microprocessor.	DROSHA DGCR8	1.20e-05	2	121	2	31956890
Pubmed	The Microprocessor controls the activity of mammalian retrotransposons.	DROSHA DGCR8	1.20e-05	2	121	2	23995758
Pubmed	Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis.	FGF21 CRTC2	1.20e-05	2	121	2	29192248
Pubmed	Signalling scaffolds and adaptors in T-cell immunity.	LCP2 LAT	1.20e-05	2	121	2	11841396
Pubmed	KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress.	KDM6B NOTCH1	1.20e-05	2	121	2	36797416
Pubmed	Development of nanoscale structure in LAT-based signaling complexes.	LCP2 LAT	1.20e-05	2	121	2	27875277
Pubmed	A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting.	DROSHA DGCR8	1.20e-05	2	121	2	26683315
Pubmed	The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation.	LCP2 LAT	1.20e-05	2	121	2	15699071
Pubmed	Molecular determinants that govern scaRNA processing by Drosha/DGCR8.	DROSHA DGCR8	1.20e-05	2	121	2	33037012
Pubmed	Structural Basis for pri-miRNA Recognition by Drosha.	DROSHA DGCR8	1.20e-05	2	121	2	32220645
Pubmed	Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA.	DROSHA DGCR8	1.20e-05	2	121	2	32220646
Pubmed	Microprocessor dynamics and interactions at endogenous imprinted C19MC microRNA genes.	DROSHA DGCR8	1.20e-05	2	121	2	22393237
Pubmed	Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches.	LFNG NOTCH1	1.20e-05	2	121	2	16699526
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	CNOT11 ABCF1 ZCCHC8 INPPL1 PPP1R13L VPS37B MRTFB DROSHA LPP IRS2 LIMCH1 PAN3 CDC23 CRTC2	1.60e-05	1038	121	14	26673895
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZCCHC8 ICE1 RCOR2 PHF21A NCOR2 KMT2D MRTFB IRS2 CDC23	1.66e-05	418	121	9	34709266
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ABCF1 ATN1 ZCCHC8 SCAF8 NCOR2 KMT2D UTP20 IRS2 LIMCH1 PRRC2A CDC23 SYMPK	1.73e-05	774	121	12	15302935
Pubmed	A census of human transcription factors: function, expression and evolution.	HIC1 FOXQ1 HMX3 HLF NR6A1 DRAP1 RCOR2 HIVEP3 MYPOP KMT2D SKOR2 ZFHX2 MNT	1.76e-05	908	121	13	19274049
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	BAZ2B KDM6B SRCAP MBD6 RCOR2 KMT2D	1.93e-05	157	121	6	30186101
Pubmed	Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis.	LFNG LRP5 NOTCH1	2.23e-05	16	121	3	19154719
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	PCED1A NRBF2 ATN1 CNTRL PPP1R13L ADAM12 ZNRF3 ARHGAP44 ADAMTSL4 NOTCH1	2.77e-05	560	121	10	21653829
Pubmed	Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation.	LCP2 LAT	3.59e-05	3	121	2	20606011
Pubmed	The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8.	DROSHA DGCR8	3.59e-05	3	121	2	36950067
Pubmed	Recurrent mutations in NF-κB pathway components, KMT2D, and NOTCH1/2 in ocular adnexal MALT-type marginal zone lymphomas.	KMT2D NOTCH1	3.59e-05	3	121	2	27566587
Pubmed	Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1.	GGA3 GGA1	3.59e-05	3	121	2	22836275
Pubmed	Fringe is a glycosyltransferase that modifies Notch.	LFNG NOTCH1	3.59e-05	3	121	2	10935626
Pubmed	Mammalian GGAs act together to sort mannose 6-phosphate receptors.	GGA3 GGA1	3.59e-05	3	121	2	14638859
Pubmed	Pineoblastoma is uniquely tolerant of mutually exclusive loss of DICER1, DROSHA or DGCR8.	DROSHA DGCR8	3.59e-05	3	121	2	32124011
Pubmed	Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization.	LCP2 LAT	3.59e-05	3	121	2	12847255
Pubmed	Dynamic Lunatic fringe expression is correlated with boundaries formation in developing mouse teeth.	LFNG NOTCH1	3.59e-05	3	121	2	10704873
Pubmed	Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region.	LFNG NOTCH1	3.59e-05	3	121	2	12486116
Pubmed	Drosha, DGCR8, and Dicer mRNAs are down-regulated in human cells infected with dengue virus 4, and play a role in viral pathogenesis.	DROSHA DGCR8	3.59e-05	3	121	2	27173348
Pubmed	Yeast and human Ysl2p/hMon2 interact with Gga adaptors and mediate their subcellular distribution.	GGA3 GGA1	3.59e-05	3	121	2	18418388
Pubmed	Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase.	KDM6B FGF21	3.59e-05	3	121	2	32042044
Pubmed	The role of Gads in hematopoietic cell signalling.	LCP2 LAT	3.59e-05	3	121	2	11607830
Pubmed	ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization.	GGA3 GGA1	3.59e-05	3	121	2	12221117
Pubmed	Expression of genes for microRNA-processing enzymes is altered in advanced non-alcoholic fatty liver disease.	DROSHA DGCR8	3.59e-05	3	121	2	23663110
Pubmed	Notch around the clock.	LFNG NOTCH1	3.59e-05	3	121	2	10508694
Pubmed	Overexpression of microRNA biogenesis machinery: Drosha, DGCR8 and Dicer in multiple sclerosis patients.	DROSHA DGCR8	3.59e-05	3	121	2	25439752
Pubmed	GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination.	GGA3 GGA1	3.59e-05	3	121	2	14660606
Pubmed	JMJD3 and NF-κB-dependent activation of Notch1 gene is required for keratinocyte migration during skin wound healing.	KDM6B NOTCH1	3.59e-05	3	121	2	28747631
Pubmed	Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling.	LFNG NOTCH1	3.59e-05	3	121	2	23072809
Pubmed	Cell cycle-dependent regulation of Aurora kinase B mRNA by the Microprocessor complex.	DROSHA DGCR8	3.59e-05	3	121	2	24589731
Pubmed	The miRNA biogenesis pathway prevents inappropriate expression of injury response genes in developing and adult Schwann cells.	DROSHA DGCR8	3.59e-05	3	121	2	30295958
Pubmed	Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor.	GGA3 GGA1	3.59e-05	3	121	2	18638397
Pubmed	Lunatic Fringe prolongs Delta/Notch-induced self-renewal of committed αβ T-cell progenitors.	LFNG NOTCH1	3.59e-05	3	121	2	21097675
Pubmed	Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia.	ADAM12 NOTCH1	3.59e-05	3	121	2	23589494
Pubmed	Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling.	LCP2 LAT	3.59e-05	3	121	2	11901197
Pubmed	Defects in cellular sorting and retroviral assembly induced by GGA overexpression.	GGA3 GGA1	3.59e-05	3	121	2	19788741
Pubmed	Reconstitution of TGFBR2 in HCT116 colorectal cancer cells causes increased LFNG expression and enhanced N-acetyl-d-glucosamine incorporation into Notch1.	LFNG NOTCH1	3.59e-05	3	121	2	27156840
Pubmed	Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members.	CDHR1 PCDH15	3.59e-05	3	121	2	20498078
Pubmed	Inactivation of the three GGA genes in HeLa cells partially compromises lysosomal enzyme sorting.	GGA3 GGA1	3.59e-05	3	121	2	33206455
Pubmed	Transcript Level of MicroRNA Processing Elements in Gastric Cancer.	DROSHA DGCR8	3.59e-05	3	121	2	30168106
Pubmed	The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors.	LCP2 LAT	3.59e-05	3	121	2	10021361
Pubmed	Role of two adaptor molecules SLP-76 and LAT in the PI3K signaling pathway in activated T cells.	LCP2 LAT	3.59e-05	3	121	2	21282515
Pubmed	Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP.	SRCAP NOTCH1	7.17e-05	4	121	2	21673954
Pubmed	A mutation in the Lunatic fringe gene suppresses the effects of a Jagged2 mutation on inner hair cell development in the cochlea.	LFNG NOTCH1	7.17e-05	4	121	2	10837254
Pubmed	Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2.	GGA3 GGA1	7.17e-05	4	121	2	27901063
Pubmed	HIV-1 Nef limits communication between linker of activated T cells and SLP-76 to reduce formation of SLP-76-signaling microclusters following TCR stimulation.	LCP2 LAT	7.17e-05	4	121	2	22802418
Pubmed	Inducing mutations in the mouse genome with the chemical mutagen ethylnitrosourea.	KMT2D PCDH15	7.17e-05	4	121	2	16972005
Pubmed	Effects of nitric oxide synthase deficiency on a disintegrin and metalloproteinase domain-containing protein 12 expression in mouse brain samples.	ADAM12 NOS3	7.17e-05	4	121	2	25892053
Pubmed	Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice.	LCP2 LAT	7.17e-05	4	121	2	15238603
Pubmed	T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression.	LCP2 LAT	7.17e-05	4	121	2	14624253
Pubmed	Wnt5a controls Notch1 signaling through CaMKII-mediated degradation of the SMRT corepressor protein.	NCOR2 NOTCH1	7.17e-05	4	121	2	22888005
Interaction	TOP3B interactions	SEMA6C CNOT11 SH3RF1 INPP5E INPPL1 PEX6 ICE1 PLXND1 KDM6B SRCAP MBD6 GGA3 HIVEP3 NHSL1 NCOR2 KMT2D SLC2A4RG NF2 ZNRF3 SETD5 ARHGAP44 LRP5 POLL IRS2 GGA1 ADAMTSL4 PRRC2A NOTCH1 SYMPK	1.53e-09	1470	113	29	int:TOP3B
Interaction	NCK2 interactions	ATN1 WIPF1 DRAP1 MBD6 LCP2 VPS37B SOCS7 NHSL1 MYPOP PRRC2A MNT	2.62e-07	262	113	11	int:NCK2
Interaction	VASP interactions	CTU2 XIRP1 NRBF2 MAP1A INPPL1 NHSL1 MICALL2 LPP IRS2 LIMCH1	6.19e-06	294	113	10	int:VASP
Interaction	DGCR6L interactions	ATN1 NAB2 GGA1 ADAMTSL4	2.62e-05	31	113	4	int:DGCR6L
Interaction	SH3RF1 interactions	XIRP1 SH3RF1 ATN1 WIPF1 LCP2 SOCS7	3.27e-05	108	113	6	int:SH3RF1
Interaction	TLE3 interactions	FOXQ1 ATN1 BAZ2B SCAF8 NAB2 NCOR2 KMT2D DZIP3 NOTCH1 CRTC2	5.12e-05	376	113	10	int:TLE3
Interaction	KDM1A interactions	NRBF2 ZCCHC8 ICE1 VPS37B RCOR2 PHF21A NCOR2 KMT2D MRTFB NF2 ITSN2 DZIP3 IRS2 NOTCH1 CDC23 SYMPK	7.09e-05	941	113	16	int:KDM1A
Cytoband	16p11.2	NPIPB7 ZNF843 SRCAP NPIPB8 LAT CFAP119	1.36e-05	191	123	6	16p11.2
Cytoband	9q21.32	SPATA31D4 SPATA31D1 SPATA31D3	1.76e-05	19	123	3	9q21.32
Cytoband	Ensembl 112 genes in cytogenetic band chr16p11	ZNF843 NPIPB9 SRCAP NPIPB8 LAT CFAP119	1.10e-04	278	123	6	chr16p11
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	1.97e-04	8	123	2	chr9q12
GeneFamily	Golgi associated, gamma adaptin ear containing, ARF binding proteins	GGA3 GGA1	4.17e-05	3	68	2	1031
GeneFamily	ESCRT-I	VPS37B VPS37D	4.93e-04	9	68	2	1116
GeneFamily	Zinc fingers CXXC-type\|Methyl-CpG binding domain containing	BAZ2B MBD6	7.50e-04	11	68	2	1025
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	RCOR2 NCOR2 MYPOP	1.04e-03	53	68	3	532
GeneFamily	LIM domain containing	MICALL2 LPP LIMCH1	1.42e-03	59	68	3	1218
GeneFamily	Cadherin related	CDHR1 PCDH15	1.83e-03	17	68	2	24
GeneFamily	Ataxins\|Trinucleotide repeat containing	NCOR2 KMT2D	3.95e-03	25	68	2	775
GeneFamily	PHD finger proteins	BAZ2B PHF21A KMT2D	4.73e-03	90	68	3	88
GeneFamily	Phosphoinositide phosphatases	INPP5E INPPL1	6.43e-03	32	68	2	1079
GeneFamily	SH2 domain containing	INPPL1 LCP2 SOCS7	6.52e-03	101	68	3	741
Coexpression	GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	SEMA6C ATN1 SRCAP PHF21A MYPOP KMT2D SETD5 DENND4B GGA1 PRRC2A SYMPK	3.28e-07	338	116	11	M17094
CoexpressionAtlas	gudmap_RNAseq_e11.5_Ureteric_stalks_2500_K0	SEMA6C PCED1A SH3RF1 INPPL1 ZBTB22 DRAP1 KDM6B MBD6 RCOR2 COL18A1 KANK1 DROSHA ARHGAP44 ZFHX2 POLL CFAP119 IRS2 MARCHF11 GGA1 CCDC17 PRRC2A VPS37D SYMPK	3.43e-07	1275	116	23	gudmap_RNAseq_e11.5_Ureteric_stalks_2500_K0
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	SH3RF1 NR6A1 NHSL1 KANK1 ARHGAP44 LPP LIMCH1 PAN3	6.73e-08	198	120	8	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MAP1A CES1 DZIP3 CC2D2A CFAP119 CCDC17 CSPP1	1.01e-06	195	120	7	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATN1 KDM6B NCOR2 IRS2 PRRC2A NOTCH1	1.14e-05	186	120	6	bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLXND1 PPP1R13L COL18A1 KANK1 NF2 ARHGAP44	1.14e-05	186	120	6	c116cc9f41971622264434ebe29d18e719b0ae19
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 KANK1 MRTFB ARHGAP44 NOS3 SEZ6	1.14e-05	186	120	6	5302399825f213d105ac70b91366a4513b732838
ToppCell	facs-Skin-nan-18m-Epithelial-Basal_IFE\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHACTR2 FOXQ1 KDM6B VPS37B NHSL1 LIMCH1	1.25e-05	189	120	6	6c71e81373cb7822de23c193a6350b6df9f567bc
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATN1 KDM6B NCOR2 IRS2 PRRC2A NOTCH1	1.25e-05	189	120	6	965e0e388251e7318f8b463816dc96ccb4658677
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Mesenchymal-choroid_plexus/mesenchymal-like_cells\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	HIC1 PHACTR2 CDHR1 LAMA2 ADAM12 COL18A1	1.44e-05	194	120	6	8ac0b63c7a89e5ff78bbdd8dd1960aa2422a85f7
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Mesenchymal\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	HIC1 PHACTR2 CDHR1 LAMA2 ADAM12 COL18A1	1.44e-05	194	120	6	4bafe26573cb2ff966f4a688c5769da598eea415
ToppCell	356C-Epithelial_cells-Epithelial-H_(AT1)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	HLF GGA3 NHSL1 MYPOP LRP5 CFAP119	1.44e-05	194	120	6	4c40d6b50675eae52c419d69e719a9223df02ae3
ToppCell	356C-Epithelial_cells-Epithelial-H_(AT1)\|356C / Donor, Lineage, Cell class and subclass (all cells)	HLF GGA3 NHSL1 MYPOP LRP5 CFAP119	1.44e-05	194	120	6	99a90de637e3babec2131cdd9f05ea965d8a8f30
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	NR6A1 HIVEP3 KANK1 LPP LIMCH1 PAN3	1.53e-05	196	120	6	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHACTR2 FOXQ1 COL18A1 KANK1 ZFHX2 NOS3	1.53e-05	196	120	6	dbf154b3d166ffd07be717dac8d8a3350ac63e16
ToppCell	critical-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MAP1A CNTRL DZIP3 CC2D2A CCDC17 CSPP1	1.62e-05	198	120	6	ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell	Bronchial-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SH3RF1 NR6A1 NHSL1 KANK1 ARHGAP44 LIMCH1	1.67e-05	199	120	6	5f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SH3RF1 NR6A1 NHSL1 KANK1 ARHGAP44 LIMCH1	1.67e-05	199	120	6	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SH3RF1 NR6A1 NHSL1 KANK1 ARHGAP44 LIMCH1	1.67e-05	199	120	6	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SH3RF1 NR6A1 NHSL1 KANK1 ARHGAP44 LIMCH1	1.67e-05	199	120	6	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	(09)_Interm._secr.>cil.\|World / shred by cell type by condition	MAP1A CNTRL DZIP3 CC2D2A CCDC17 CSPP1	1.72e-05	200	120	6	3305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Fibroblasts\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCED1A ADAM12 HIVEP3 MICALL2 PCDH15	4.74e-05	146	120	5	86cddd0e7f954547b7ffdccb0329cd5c4b725ac1
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCED1A LFNG COL18A1 ARHGAP44 ZNF385C	6.70e-05	157	120	5	a426c54fd1545093d41426e9620862f71bd06f6b
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Fibroblasts-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCED1A ZBTB22 ADAM12 HIVEP3 PCDH15	6.90e-05	158	120	5	7f5426585d0d299d2b48e5fcb349950feffdef33
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SH3RF1 NR6A1 SOCS7 KANK1 LIMCH1	7.11e-05	159	120	5	8680b054622f573a82b1625fb93c2d5db81d1034
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CDHR1 NR6A1 ADAM12 FAM171A2 LIMCH1	7.99e-05	163	120	5	f4fcac0af9967ec34a43c9674aa17b0aa5344cf6
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NYAP2 MAP1A DROSHA INSM2 LIMCH1	7.99e-05	163	120	5	132aece9c79499b4bb3c2bde68d3d7202e1d8772
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA6C PLXND1 LCP2 ZNF385D NOS3	8.71e-05	166	120	5	ec719368295133da2f7ff587c5329ed6db1dd56d
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	MAP1A CC2D2A LRP5 CFAP119 ZNF385C	9.22e-05	168	120	5	968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCell	facs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHACTR2 KANK1 ZFHX2 NOS3 NOTCH1	9.22e-05	168	120	5	06dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCell	facs-Heart-RA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHACTR2 KANK1 ZFHX2 NOS3 NOTCH1	9.22e-05	168	120	5	1002f058a340763e3d8de0bd1f0547a903526ec6
ToppCell	Control-Epithelial_cells-ECM-high_epithelial\|Control / group, cell type (main and fine annotations)	SH3RF1 HMX3 NR6A1 ARHGAP44 LIMCH1	9.74e-05	170	120	5	e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SEMA6C NPIPB9 NR6A1 NHSL1 ZFHX2	1.00e-04	171	120	5	1854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LCP2 VPS37B MYPOP LAT DROSHA	1.00e-04	171	120	5	f1fdc0ec3399ed6955976d02be7e5fc329a64276
ToppCell	droplet-Kidney-nan-21m-Lymphocytic-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WIPF1 LCP2 VPS37B HIVEP3 LAT	1.15e-04	176	120	5	feafc757e7aa4f17128ff34886beb2fd3461c9ea
ToppCell	facs-MAT-Fat-3m-Lymphocytic-T_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NYAP2 LCP2 VPS37B SPATA31D3 LAT	1.15e-04	176	120	5	71b3309ddadd035a1224fca4fc5946dc4c0283fe
ToppCell	facs-Spleen-nan-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LCP2 LFNG LAT ZNRF3 NOTCH1	1.18e-04	177	120	5	ac0cf03e2a1baf84db3ae245d59bbc6ae52c13be
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL18A1 KANK1 ARHGAP44 NOS3 SEZ6	1.18e-04	177	120	5	d68132e145bd413404fdbe215b5dbe520e756e50
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLXND1 KANK1 MRTFB ARHGAP44 NOS3	1.21e-04	178	120	5	9f59a9af232d77bb55603a7776dbf9749ea652f2
ToppCell	facs-Heart-RA-18m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIC1 KDM6B LCP2 LAT FAM171A2	1.21e-04	178	120	5	b505e2550860e777535ee95f29c936242fd607f1
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPATA31A7 PLXND1 RTL8C PRRC2A SYMPK	1.27e-04	180	120	5	81d60f0fa9e3b5bfcec85139a0a49e9130145f0e
ToppCell	facs-Spleen-nan-3m-Lymphocytic-Cd3e_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LCP2 LFNG LAT ZNRF3 NOTCH1	1.31e-04	181	120	5	be7c7db6b99603759593e6f79cdcaa4bbf234cb7
ToppCell	facs-Spleen-nan-18m-Lymphocytic-Cd3e_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHACTR2 LCP2 LFNG LAT NOTCH1	1.34e-04	182	120	5	da3e9093cba791c7c282eb044656046252a32789
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KANK1 MRTFB ARHGAP44 NOS3 SEZ6	1.34e-04	182	120	5	ebc812ed3f25839ea25f76b952c463d79a8325b1
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KANK1 MRTFB ARHGAP44 NOS3 SEZ6	1.34e-04	182	120	5	47ff6b4002a4167412c79210651316d1342503f9
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXQ1 SOCS7 KANK1 ZFHX2 NOTCH1	1.38e-04	183	120	5	b0b5a41f1a40f9c946d0dc8b67eaccdd9f9b73a5
ToppCell	3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLXND1 RCOR2 MRTFB LIMCH1 NOS3	1.41e-04	184	120	5	842473fa415575441b595073a994b6d621169776
ToppCell	facs-Spleen-nan-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LCP2 LFNG LAT ZNRF3 NOTCH1	1.41e-04	184	120	5	c37c623c4a5ff1628486d8a6461fa355ad5c264c
ToppCell	E12.5-Endothelial-capillary_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PLXND1 COL18A1 LAT LIMCH1 NOS3	1.45e-04	185	120	5	e005d3c01a908157f780bbc1d53dd2ed814a39d2
ToppCell	E12.5-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PLXND1 COL18A1 LAT LIMCH1 NOS3	1.45e-04	185	120	5	0bccc424d0466f7f82baa00127c733640a2d50fb
ToppCell	droplet-Lung-LUNG-1m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 NHSL1 KANK1 ARHGAP44 NOS3	1.48e-04	186	120	5	1e67bfb248366d7395efdd2d5e70a97bdb2e68af
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_3\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	CNOT11 HLF LFNG PHF21A CDC23	1.52e-04	187	120	5	689b3cc76f1e04bd35a7d3ce19e9f08744a7835b
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CNOT11 HLF LFNG PHF21A CDC23	1.52e-04	187	120	5	4527d6426f2c4397e47f12439a13a8c14fd2aab2
ToppCell	facs-Heart-LA-24m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHACTR2 KANK1 ZFHX2 NOS3 NOTCH1	1.52e-04	187	120	5	d9943e65eedab73d141eae524e2411653a751705
ToppCell	facs-Heart-LA-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHACTR2 KANK1 ZFHX2 NOS3 NOTCH1	1.52e-04	187	120	5	7b13c3b67d66f3afb410141d5471c9e78a4d8623
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-neuron_precursor\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NYAP2 HMX3 ZFHX2 NALF2 SEZ6	1.56e-04	188	120	5	9fd262bbf6cdebfd945e39428a6059726fb55b3a
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-neuron_precursor-Neuroblast\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NYAP2 HMX3 ZFHX2 NALF2 SEZ6	1.56e-04	188	120	5	459e3fd4335a6f25f982d011b38702f4fcfed1cd
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	SH3RF1 NR6A1 KANK1 ARHGAP44 LIMCH1	1.56e-04	188	120	5	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HLF NR6A1 ZNF385D KANK1 LIMCH1	1.60e-04	189	120	5	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-Basal_IFE\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXQ1 KDM6B VPS37B NHSL1 LIMCH1	1.60e-04	189	120	5	1cfc1fe27c4b57b4e52700fa8f679ce172cee5a9
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIC1 SH3RF1 PLXND1 CFAP119 NOS3	1.60e-04	189	120	5	ce5b3d53c9a5457a5a02b221dee18334b5eaf8b7
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NHSL1 KANK1 ZNRF3 ARHGAP44 LIMCH1	1.64e-04	190	120	5	8aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCell	facs-Heart-LA-24m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 KDM6B LIMCH1 NOS3 NOTCH1	1.64e-04	190	120	5	911b93c4c828ef2d867b91a5eced2dc12a1baf27
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDHR1 KANK1 ZFHX2 CCDC17 NOS3	1.64e-04	190	120	5	6f71a9f74af7cd9a674753cfc9833ebe5bba0fa2
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-Double_negative_Thymocyte,_DN4_(Cd8-,_Cd4-),_some_undergoing_VDJ_recombination_\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAB2 KDM6B LCP2 HIVEP3 LAT	1.64e-04	190	120	5	d85b34d19af43d83ebe728f3c7bbefd3792df4a6
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXQ1 KDM6B VPS37B ZNRF3 LIMCH1	1.64e-04	190	120	5	3639eb9b887a2d76949cad4a2586524fe0e1015f
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-Double_negative_Thymocyte,_DN4_(Cd8-,_Cd4-),_some_undergoing_VDJ_recombination_\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAB2 KDM6B LCP2 HIVEP3 LAT	1.64e-04	190	120	5	8f5e71a0861ee4e8f3ce45e8a7f18fb9d6036a3c
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-double_negative_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAB2 KDM6B LCP2 HIVEP3 LAT	1.64e-04	190	120	5	84265be128170cbb08d76e824aa108e07da9c3e5
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LFNG NHSL1 KANK1 MICALL2 NOTCH1	1.64e-04	190	120	5	b56c55f608b30f7379941ac7d5f0f5200f305fca
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	WIPF1 KDM6B LCP2 CC2D2A IRS2	1.68e-04	191	120	5	47156e5f1d790707f42f6283104a44b33af613e5
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLXND1 KANK1 MRTFB ARHGAP44 NOS3	1.68e-04	191	120	5	6e6b2cb390cc5cd0356924a2c36fbe5b5bd5966c
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLXND1 KANK1 MRTFB ARHGAP44 NOS3	1.68e-04	191	120	5	482db995930346be69072ace2fd78fd453e97fb5
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NHSL1 KANK1 ZNRF3 ARHGAP44 LIMCH1	1.68e-04	191	120	5	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SH3RF1 KANK1 ZNRF3 ARHGAP44 LIMCH1	1.68e-04	191	120	5	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLXND1 ZNF385D MRTFB LIMCH1 NOS3	1.72e-04	192	120	5	eafead22bba48ac5ee568faa8946c444445c1034
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	SH3RF1 KANK1 ZNRF3 ARHGAP44 LIMCH1	1.72e-04	192	120	5	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NHSL1 KANK1 ZNRF3 ARHGAP44 LIMCH1	1.72e-04	192	120	5	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	HLF NR6A1 KANK1 ZNRF3 LRP5	1.76e-04	193	120	5	503a979328c68b096680b71359a26f02fafdff35
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_2\|Classical_Monocyte / Disease condition and Cell class	MAP1A KDM6B LCP2 LFNG LAT	1.76e-04	193	120	5	add29b6abdfa49c7f0a0f49841a588d03e3bdb48
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLXND1 ZNF385D MRTFB LIMCH1 NOS3	1.76e-04	193	120	5	c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LAMA2 HIVEP3 PCDH15 IRS2 LIMCH1	1.81e-04	194	120	5	e93de9428c986b8943fc169258847c650cfab0e5
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SH3RF1 NR6A1 KANK1 ARHGAP44 LIMCH1	1.81e-04	194	120	5	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	CES1 DZIP3 CC2D2A CCDC17 CSPP1	1.81e-04	194	120	5	b4ce60c06568123008b1081d644733cb91c28f51
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SH3RF1 NR6A1 COL18A1 KANK1 ZNRF3	1.81e-04	194	120	5	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HIC1 FOXQ1 ADAM12 COL18A1 ARHGAP44	1.81e-04	194	120	5	78dcb9d48259afabe73b41c5508a73a8d62339a4
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	CES1 DZIP3 CC2D2A CCDC17 CSPP1	1.81e-04	194	120	5	7a7ddccfe72a4a0dc4d1a5c809988f0069f9f1a3
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAP1A UBQLN3 DZIP3 CCDC17 CSPP1	1.85e-04	195	120	5	649fd2336e963f6a150d182a53ad5dd838ca80b1
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAP1A UBQLN3 DZIP3 CCDC17 CSPP1	1.85e-04	195	120	5	129ad5f4253ecb1a8477cc38773e6e91ea9570b0
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAP1A UBQLN3 DZIP3 CCDC17 CSPP1	1.85e-04	195	120	5	3e70ee987d66d450062d5df3d7c733ccc7344470
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SH3RF1 NR6A1 KANK1 ARHGAP44 LIMCH1	1.85e-04	195	120	5	9406866f99555198a9be311fbd65751b70f35446
ToppCell	moderate-Epithelial-Ciliated\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MAP1A CES1 CC2D2A CCDC17 CSPP1	1.85e-04	195	120	5	e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCell	COVID-19-Epithelial-Ciliated_cells\|Epithelial / Condition, Lineage and Cell class	MAP1A CES1 DZIP3 CCDC17 CSPP1	1.89e-04	196	120	5	de7aa31354b019d7321a8ef965d59ce2e8b89276
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_pericyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FOXQ1 LAMA2 ADAM12 COL18A1 ARHGAP44	1.89e-04	196	120	5	cb61757646653f89faba503cb5d99e5dd5197b4c
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDHR1 COL18A1 KANK1 ZFHX2 NOS3	1.89e-04	196	120	5	7d5eaed189aa6116f3799be010139fb675ec65e0
ToppCell	critical-Epithelial-Ciliated\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MAP1A DZIP3 CC2D2A CCDC17 CSPP1	1.89e-04	196	120	5	27b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCell	facs-Skin-Telogen-3m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3RF1 COL18A1 KANK1 LPP ADAMTSL4	1.89e-04	196	120	5	c936014125b2ed5f796221b74acb77b8f8359875
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXND1 KANK1 ZFHX2 NOS3 NOTCH1	1.89e-04	196	120	5	e386526332138e636aef2542c11316347a45689c
ToppCell	(3)_MNP-(3)_Monocyte\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	KDM6B SRCAP LCP2 VPS37B IRS2	1.89e-04	196	120	5	83af2eb1c28dfe7678d972be1d6d358c4a94731d
ToppCell	mild_COVID-19_(asymptomatic)\|World / disease group, cell group and cell class (v2)	HIC1 ABCF1 DRAP1 LFNG HIVEP3	1.89e-04	196	120	5	8cb3dcb3e5732f4bb060c87ca339b8997a1a8cd4
ToppCell	5'-Adult-Appendix\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMA2 KDM6B ADAM12 ZNF385D COL18A1	1.89e-04	196	120	5	a579211ef14f348d0c5a290553150222dfbf1515
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_pericyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FOXQ1 LAMA2 ADAM12 COL18A1 ARHGAP44	1.89e-04	196	120	5	44e2df1b61e3819eae7e482bef0a733afe852d67
ToppCell	5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLXND1 ZNF385D MRTFB LIMCH1 NOS3	1.94e-04	197	120	5	87eda06344498dc66cac292cf89746dc90b5cf67
Drug	Disopyramide [3737-09-5]; Up 200; 11.8uM; MCF7; HT_HG-U133A	MAP1A SRCAP GGA3 COL18A1 LRP5 NALF2 GGA1 PRRC2A	6.23e-06	198	112	8	7035_UP
Drug	Bendroflumethiazide [73-48-3]; Up 200; 9.4uM; MCF7; HT_HG-U133A	NAB2 HLF SRCAP HIVEP3 NF2 IRS2 LIMCH1 DGCR8	6.71e-06	200	112	8	3840_UP
Drug	pyrvinium pamoate; Up 200; 1.25uM; MCF7; HT_HG-U133A_EA	KDM6B SRCAP ZFHX2 POLL GGA1 NOTCH1 SYMPK	2.14e-05	170	112	7	978_UP
Drug	Decamethonium bromide [541-22-0]; Down 200; 9.6uM; PC3; HT_HG-U133A	WIPF1 NAB2 KDM6B NF2 ARHGAP44 CSPP1 SYMPK	4.52e-05	191	112	7	4094_DN
Drug	11-deoxy-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; PC3; HT_HG-U133A	ATN1 PLXND1 NF2 LPP POLL DGCR8 NOTCH1	4.52e-05	191	112	7	7538_UP
Drug	Equilin [474-86-2]; Up 200; 15uM; MCF7; HT_HG-U133A	CNTRL NAB2 HLF NR6A1 ADAM12 POLL LIMCH1	4.67e-05	192	112	7	5620_UP
Drug	2-propylpentanoic acid; Up 200; 500uM; MCF7; HT_HG-U133A	MAP1A NR6A1 SRCAP HIVEP3 LAT LIMCH1 DGCR8	4.82e-05	193	112	7	5600_UP
Drug	Muramic acid, N-acetyl [10597-89-4]; Up 200; 13.6uM; MCF7; HT_HG-U133A	ATN1 WIPF1 PPP1R13L VPS37B COL18A1 PRRC2A SYMPK	4.82e-05	193	112	7	3262_UP
Drug	Indoprofen [31842-01-0]; Down 200; 14.2uM; PC3; HT_HG-U133A	ATN1 KDM6B COL18A1 NF2 POLL DGCR8 RTL8C	4.98e-05	194	112	7	4249_DN
Drug	Lobelanidine hydrochloride [6112-86-3]; Down 200; 10.6uM; MCF7; HT_HG-U133A	KDM6B SRCAP NF2 LPP ZFHX2 IRS2 DGCR8	5.32e-05	196	112	7	2897_DN
Drug	Diflorasone Diacetate [33564-31-7]; Up 200; 8uM; MCF7; HT_HG-U133A	ATN1 NAB2 NR6A1 SRCAP GGA3 IRS2 DGCR8	5.32e-05	196	112	7	2798_UP
Drug	Methiazole; Down 200; 15uM; MCF7; HT_HG-U133A	ATN1 SRCAP NCOR2 NF2 POLL LIMCH1 DGCR8	5.32e-05	196	112	7	3878_DN
Drug	PF-00539745-00 [351321-33-0]; Up 200; 10uM; PC3; HT_HG-U133A	WIPF1 HLF PLXND1 GGA3 NCOR2 NF2 GGA1	5.32e-05	196	112	7	5979_UP
Drug	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A	MAP1A PRR36 ADAM12 ZFHX2 POLL IRS2 DGCR8	5.49e-05	197	112	7	7500_UP
Drug	Harmaline hydrochloride dihydrate [6027-98-1]; Down 200; 14uM; PC3; HT_HG-U133A	MAP1A PEX6 ZNF385D NCOR2 MICALL2 DZIP3 GGA1	5.49e-05	197	112	7	6623_DN
Drug	Ajmalicine hydrochloride [4373-34-6]; Up 200; 10.2uM; MCF7; HT_HG-U133A	ATN1 SRCAP ADAM12 GGA3 HIVEP3 LAT LIMCH1	5.49e-05	197	112	7	2898_UP
Drug	Idazoxan hydrochloride [79944-56-2]; Up 200; 16.6uM; HL60; HT_HG-U133A	MAP1A NR6A1 ADAM12 SOCS7 GGA3 DZIP3 SYMPK	5.49e-05	197	112	7	3088_UP
Drug	(R) -Naproxen sodium salt [26159-34-2]; Up 200; 15.8uM; MCF7; HT_HG-U133A	NR6A1 ADAM12 GGA3 HIVEP3 NCOR2 NF2 DGCR8	5.49e-05	197	112	7	6096_UP
Drug	Fenbufen [36330-85-5]; Up 200; 15.8uM; MCF7; HT_HG-U133A	NR6A1 SRCAP HIVEP3 KMT2D LIMCH1 DGCR8 ADAMTSL4	5.49e-05	197	112	7	2308_UP
Drug	16, 16-dimethylprostaglandin E2 methyl acetate solution; Down 200; 10uM; PC3; HT_HG-U133A	ATN1 PLXND1 KDM6B HIVEP3 COL18A1 MICALL2 NF2	5.67e-05	198	112	7	6592_DN
Drug	Deltaline [6836-11-9]; Up 200; 7.8uM; MCF7; HT_HG-U133A	PHACTR2 ATN1 NAB2 NR6A1 SRCAP HIVEP3 DGCR8	5.67e-05	198	112	7	3831_UP
Drug	AG-028671 [847803-03-6]; Down 200; 10uM; MCF7; HT_HG-U133A	ATN1 PRR36 INPPL1 SRCAP NF2 POLL LIMCH1	5.67e-05	198	112	7	6587_DN
Drug	U-62066 [87151-85-7]; Down 200; 1uM; MCF7; HT_HG-U133A	ATN1 SRCAP NCOR2 IRS2 LIMCH1 DGCR8 SYMPK	5.67e-05	198	112	7	3901_DN
Drug	Graveoline [485-61-0]; Up 200; 14.4uM; MCF7; HT_HG-U133A	HLF NR6A1 HIVEP3 NCOR2 LAT LIMCH1 DGCR8	5.67e-05	198	112	7	6034_UP
Drug	Ribavirin [36791-04-5]; Down 200; 16.4uM; HL60; HT_HG-U133A	MRTFB NF2 ARHGAP44 POLL DGCR8 GGA1 NOTCH1	5.67e-05	198	112	7	3142_DN
Drug	Practolol [6673-35-4]; Down 200; 15uM; MCF7; HT_HG-U133A	CNTRL PLXND1 KDM6B DZIP3 POLL LIMCH1 CSPP1	5.85e-05	199	112	7	5664_DN
Drug	Propylthiouracil [51-52-5]; Up 200; 23.4uM; MCF7; HT_HG-U133A	HLF NR6A1 ADAM12 LAT POLL IRS2 SYMPK	5.85e-05	199	112	7	4157_UP
Drug	Ungerine nitrate; Up 200; 10.2uM; MCF7; HT_HG-U133A	ATN1 MAP1A SRCAP ADAM12 ZNF385D NCOR2 NF2	5.85e-05	199	112	7	6076_UP
Drug	Methapyrilene hydrochloride [135-23-9]; Up 200; 13.4uM; MCF7; HT_HG-U133A	MAP1A PRR36 LAMA2 SRCAP HIVEP3 LAT IRS2	5.85e-05	199	112	7	4990_UP
Drug	Dipyrone [5907-38-0]; Up 200; 12uM; MCF7; HT_HG-U133A	ATN1 MAP1A HIVEP3 LAT ZFHX2 LIMCH1 NALF2	5.85e-05	199	112	7	3835_UP
Drug	Thiethylperazine malate [52239-63-1]; Down 200; 6uM; PC3; HT_HG-U133A	MAP1A ADAM12 GGA3 NF2 DZIP3 ZFHX2 CSPP1	5.85e-05	199	112	7	5756_DN
Drug	Doxylamine succinate [562-10-7]; Up 200; 10.2uM; HL60; HG-U133A	PHACTR2 WIPF1 KDM6B SRCAP PPP1R13L KANK1 DGCR8	5.85e-05	199	112	7	1973_UP
Drug	Myosmine [532-12-7]; Up 200; 27.4uM; MCF7; HT_HG-U133A	ATN1 CDHR1 LAMA2 LAT LIMCH1 DGCR8 ADAMTSL4	6.04e-05	200	112	7	4759_UP
Drug	Eucatropine hydrochloride [536-93-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A	NR6A1 KMT2D FGF21 UBQLN3 ZFHX2 DGCR8 GGA1	6.04e-05	200	112	7	3935_UP
Drug	Tolfenamic acid [13710-19-5]; Up 200; 15.2uM; MCF7; HT_HG-U133A	WIPF1 CDHR1 HLF NCOR2 LAT IRS2 ADAMTSL4	6.04e-05	200	112	7	5454_UP
Drug	CAY10397; Up 200; 10uM; MCF7; HT_HG-U133A	ATN1 NAB2 NR6A1 NF2 ZFHX2 LIMCH1 DGCR8	6.04e-05	200	112	7	7082_UP
Disease	Malignant neoplasm of breast	CTU2 HIC1 XIRP1 FOXQ1 LAMA2 ADAM12 GGA3 KMT2D NF2 ITSN2 UTP20 GGA1 PRRC2A NOS3 NOTCH1	6.94e-06	1074	106	15	C0006142
Disease	Profound Mental Retardation	ZCCHC8 NTF4 INPP5E PEX6 KDM6B COL18A1	1.14e-05	139	106	6	C0020796
Disease	Mental Retardation, Psychosocial	ZCCHC8 NTF4 INPP5E PEX6 KDM6B COL18A1	1.14e-05	139	106	6	C0025363
Disease	Mental deficiency	ZCCHC8 NTF4 INPP5E PEX6 KDM6B COL18A1	1.14e-05	139	106	6	C0917816
Disease	fat intake measurement	FGF21 ITSN2 VPS37D	6.60e-05	22	106	3	EFO_0010809
Disease	COACH syndrome	INPP5E CC2D2A	7.63e-05	4	106	2	C1857662
Disease	Miller-Dieker lissencephaly syndrome (implicated_via_orthology)	HIC1 MNT	1.27e-04	5	106	2	DOID:0060469 (implicated_via_orthology)
Disease	testosterone measurement	NYAP2 SPEM3 NRBF2 MAP1A HLF KDM6B SRCAP GGA3 NCOR2 MYPOP SLC2A4RG SKOR2 LRP5 VPS37D	1.90e-04	1275	106	14	EFO_0004908
Disease	Intellectual Disability	ATN1 ZCCHC8 NTF4 INPP5E PEX6 KDM6B PHF21A COL18A1	2.15e-04	447	106	8	C3714756
Disease	Joubert syndrome (implicated_via_orthology)	INPP5E CC2D2A	2.65e-04	7	106	2	DOID:0050777 (implicated_via_orthology)
Disease	platelet component distribution width	NYAP2 WIPF1 HLF COL18A1 NCOR2 LPP IRS2 PRRC2A NOS3 VPS37D	3.97e-04	755	106	10	EFO_0007984
Disease	Male sterility	KMT2D DROSHA NOS3	6.93e-04	48	106	3	C0917731
Disease	Male infertility	KMT2D DROSHA NOS3	6.93e-04	48	106	3	C0021364
Disease	Subfertility, Male	KMT2D DROSHA NOS3	6.93e-04	48	106	3	C0848676
Disease	developmental disorder of mental health (implicated_via_orthology)	PLXND1 SRCAP NCOR2	7.36e-04	49	106	3	DOID:0060037 (implicated_via_orthology)
Disease	Meckel-Gruber syndrome	CC2D2A CSPP1	1.30e-03	15	106	2	C0265215
Disease	total cholesterol measurement, very low density lipoprotein cholesterol measurement	NYAP2 NRBF2 MAP1A NCOR2 FGF21	1.31e-03	224	106	5	EFO_0004574, EFO_0008317
Disease	bitter alcoholic beverage consumption measurement	KDM6B ZNF385D MICALL2 SETD5	1.37e-03	133	106	4	EFO_0010092
Disease	lysosomal storage disease (implicated_via_orthology)	GGA3 GGA1	1.48e-03	16	106	2	DOID:3211 (implicated_via_orthology)
Disease	Meckel syndrome type 1	CC2D2A CSPP1	1.88e-03	18	106	2	C3714506
Disease	mean corpuscular hemoglobin concentration	NYAP2 NRBF2 ATN1 MYPOP SLC2A4RG ZNRF3 CC2D2A LRP5 IRS2 PAN3 VPS37D	2.10e-03	1105	106	11	EFO_0004528
Disease	renal system measurement	SCAF8 MICALL2	2.33e-03	20	106	2	EFO_0004742
Disease	Familial aplasia of the vermis	INPP5E CC2D2A	2.33e-03	20	106	2	cv:C0431399
Disease	response to alcohol	LAMA2 ZNF385D PCDH15	2.52e-03	75	106	3	EFO_0005526
Disease	treatment resistant depression, response to antidepressant	HIVEP3 ZNF385D	2.57e-03	21	106	2	EFO_0009854, GO_0036276
Disease	Joubert syndrome 1	INPP5E CSPP1	2.57e-03	21	106	2	C4551568
Disease	Metabolic Syndrome X	INPPL1 NOS3	2.57e-03	21	106	2	C0524620
Disease	gastric ulcer (biomarker_via_orthology)	COL18A1 NOS3	2.57e-03	21	106	2	DOID:10808 (biomarker_via_orthology)
Disease	osteoporosis (biomarker_via_orthology)	LRP5 IRS2	2.82e-03	22	106	2	DOID:11476 (biomarker_via_orthology)
Disease	granulocyte percentage of myeloid white cells	NYAP2 KDM6B LPP PAN3 VPS37D	2.86e-03	268	106	5	EFO_0007997
Disease	Mammary Carcinoma, Human	CTU2 HIC1 FOXQ1 KMT2D ITSN2 NOS3 NOTCH1	2.91e-03	525	106	7	C4704874
Disease	Mammary Neoplasms, Human	CTU2 HIC1 FOXQ1 KMT2D ITSN2 NOS3 NOTCH1	2.91e-03	525	106	7	C1257931
Disease	Mammary Neoplasms	CTU2 HIC1 FOXQ1 KMT2D ITSN2 NOS3 NOTCH1	2.97e-03	527	106	7	C1458155
Disease	Cleft Palate	ATN1 NOS3 MNT	3.14e-03	81	106	3	C0008925
Disease	Breast Carcinoma	CTU2 HIC1 FOXQ1 KMT2D ITSN2 NOS3 NOTCH1	3.33e-03	538	106	7	C0678222
Disease	airway responsiveness measurement	PCDH15 DZIP3	3.35e-03	24	106	2	EFO_0006897
Disease	apolipoprotein A 1 measurement	XIRP1 NYAP2 MAP1A CES1 PEX6 COL18A1 NCOR2 SLC2A4RG CCDC17	3.52e-03	848	106	9	EFO_0004614

Protein segments in the cluster

Peptide	Gene	Start	Entry
SLPLPTRPLQPPLDF	ZNF385C	16	Q66K41
LPALVRPPAPPLQPS	ZNF385D	16	Q9H6B1
AKPPLGPLRFTPPQP	CES1	56	P23141
LDALRALLPPPPPSP	FAM246A	146	A0A494C0Y3
LDALRALLPPPPPSP	FAM246B	146	A0A494C0N9
RFTFPDPPPLSPPVL	ABCF1	611	Q8NE71
APPLPPLPGFSEPQL	CCDC17	351	Q96LX7
SLPALPLAELQPPPP	CDC23	61	Q9UJX2
SLLPRAPALPPPPSV	CDHR1	786	Q96JP9
ALYAPPPPLPNNSRP	CNTRL	1261	Q7Z7A1
VQLHPSLPLPPRPPR	ADAMTSL4	76	Q6UY14
PPLLGIPPLFAPPAQ	BAZ2B	131	Q9UIF8
HVTPNLPPPPALRPL	ATN1	296	P54259
PNPPQKPLPADPLAR	ADAM12	851	O43184
LSPFLLLPPRPPPAR	C1orf94	286	Q6P1W5
PFQALPREQSPPPPL	DGCR8	26	Q8WYQ5
LLQTALSPPPPPTRP	POLL	161	Q9UGP5
FLPFASTLPLPPAPP	DRAP1	176	Q14919
LSQPPPLLRPPLPTA	RCOR2	446	Q8IZ40
PLPTAPTLLRQPPPL	RCOR2	456	Q8IZ40
PIESQPPPSTLPPFL	NTF4	21	P34130
QPLPLTLPPELVPPS	ITSN2	316	Q9NZM3
LPRPPTISNPPPLIS	NCOR2	1096	Q9Y618
PQPFSLPEPSQPILP	MBD6	396	Q96DN6
PPLLPSPFQQSPSVP	NOTCH1	2216	P46531
LLVLTADPPPPPLPA	LFNG	21	Q8NES3
VPKDRPLPPAPLSPA	MAP1A	1846	P78559
PSLLPPRPPPALSLD	INPP5E	186	Q9NRR6
PRLTPPPADLPLALP	NAB2	431	Q15742
EPPLALPSLPPLPFQ	HIC1	281	Q14526
PKPQPPPRTLFAPAS	HMX3	46	A6NHT5
PPLSQPDLLPIPRSP	LAT	71	O43561
ATLYPPILNPPPSPA	LRP5	1491	O75197
PILNPPPSPATDPSL	LRP5	1496	O75197
FPPPPYLARSIDPLP	KDM6B	571	O15054
DPPLVPLTLALPPAP	KDM6B	596	O15054
PPRPALSPILPDSPV	NHSL1	996	Q5SYE7
LPSPAPARKPPLSPA	MICALL2	141	Q8IY33
PPFQTPPRCPVPLLL	PLXND1	21	Q9Y4D7
PFPTETPPLAVLLPP	PEX6	11	Q13608
EHLALLPPPPSSLPP	PCED1A	306	Q9H1Q7
ILASPPRLPEPQPYP	COL18A1	1536	P39060
FQTPLPPLSAPSVPP	CSPP1	486	Q1MSJ5
PARFLPLPGLPPALP	FGF21	161	Q9NSA1
LFVPLPPSPLPPSVD	NPIPB8	346	E9PQR5
FLKTPPTADQPPPRP	MRTFB	231	Q9ULH7
PQFIPPPRLTPRPNF	PHF21A	216	Q96BD5
PPPPLETSLPFLTIP	KANK1	121	Q14678
LPSISGNFPPPPPLD	LPP	81	Q93052
PLPSRPQVPTPAPLL	MNT	136	Q99583
LALPSPPRPSPPLLS	KRTAP4-16	181	G5E9R7
LPDDTTFPLPPPRPK	GGA1	151	Q9UJY5
LIPSPPPRPKNPVFD	GGA3	156	Q9NZ52
PPEFQPSPLRNIPPF	LAMA2	2666	P24043
LFEPTTPAPPLRPPD	NALF2	156	O75949
PAPSPLAPPLPLEDQ	PHACTR2	331	O75167
RPLPLNPTFIPPPYG	HLF	6	Q16534
PLPPSPLPPSVDDNL	NPIPB7	331	O75200
DIPPPFPNLLSHRPP	NYAP2	321	Q9P242
PFPEPALQPDPAPLS	INSM2	171	Q96T92
PLPPSPLPPSVDDNL	NPIPB15	326	A6NHN6
FALSTLPPVQLPPPP	DZIP3	941	Q86Y13
IPIPNLPPLDFPSPE	NRBF2	256	Q96F24
PIPAPLPPDIPSFNL	NF2	486	P35240
PEPSRAPASLLPPAP	NOS3	36	P29474
PPPPAPPRLALSEDT	FAM171A2	716	A8MVW0
SLFPLEPLPPPNRIQ	PAN3	481	Q58A45
LSPEASSPYPPLPPR	IRS2	1006	Q9Y4H2
IPLPLPPPTFFPLSV	PCDH15	1786	Q96QU1
DPGANLFPPPLPRPR	CFAP119	61	A1A4V9
FFKLPPPLLSPVPSP	ICE1	336	Q9Y2F5
PLPPLLAPLIATPPR	ICE1	1631	Q9Y2F5
LALPNPIKPFPSRPP	CC2D2A	351	Q9P2K1
PDLTNLHFPPPLPTP	CRTC2	276	Q53ET0
PRYLPPLPASPETPE	MARCHF11	46	A6NNE9
SPASRIPPPELPPDL	DENND4B	1071	O75064
IPSPPLPPSPLDFSA	C19orf54	26	Q5BKX5
LPPSPLDFSALPSPP	C19orf54	31	Q5BKX5
PPLPSPLLPTRLPDD	RTL8C	121	O15255
SPIPPPPFLRASFNP	SCAF8	671	Q9UPN6
PPFLRASFNPSQPPP	SCAF8	676	Q9UPN6
PLFTRAPPPKLQPQP	PPP1R13L	396	Q8WUF5
PPLDPQNLARPPAPA	CTU2	206	Q2VPK5
PLPPSPLPPSVDDNL	NPIPB9	346	F8W1W9
VPPTAPPLLLAPLPA	FOXQ1	341	Q9C009
LQPLQPEPPPEPAFS	LIMCH1	11	Q9UPQ0
LEPPAALPPPPRNGF	NR6A1	21	Q15406
PRLPPQSCLLLPPTP	UTP20	2051	O75691
SPAPNFLPPRPDFVP	DROSHA	66	Q9NRR4
QPSPLFPPLEFRPVP	POLR3GL	36	Q9BT43
LPLEHPSPEPPALFP	SPATA31A6	191	Q5VVP1
TPPLENLPSLAPPPL	PRR36	731	Q9H6K5
LATPPPQAPPALALP	PRR36	836	Q9H6K5
ALALPPLQAPPSPPA	PRR36	846	Q9H6K5
TPPLQALPSPPASFP	PRR36	1016	Q9H6K5
LLEPVPSSPLQPLPP	PRR23B	221	Q6ZRT6
LPLEHPSPEPPALFP	SPATA31A7	191	Q8IWB4
PLPPPPPSSSAVFRL	PRRC2A	1451	P48634
LQPPSLAVRPPPAPA	PRRC2A	2016	P48634
PDFPPPPLPDSAIFL	INPPL1	1051	O15357
RNPNATELPLLPPPP	SETD5	416	Q9C0A6
SPVLPPPQPLFLPST	SPATA31D4	541	Q6ZUB0
PPQPLFLPSTQPLPL	SPATA31D4	546	Q6ZUB0
PQSPFPALPPSPLFL	SPATA31D4	581	Q6ZUB0
AILAPSPAPPLAPLP	SRCAP	1596	Q6ZRS2
PPPPPRSPFYLDSLE	SRCAP	1876	Q6ZRS2
PAPPAELAAPLPSPL	ARHGAP44	546	Q17R89
NPPLPPPPLLAATVL	SH3RF1	396	Q7Z6J0
FSASPLPPLLPPPFP	C11orf53	81	Q8IXP5
DRPPLSGFLPPITPP	CNOT11	166	Q9UKZ1
LPLEHPSPEPPALFP	SPATA31A3	191	Q5VYP0
SPVLPPPQPLFLPST	SPATA31D3	541	P0C874
PPQPLFLPSTQPLPL	SPATA31D3	546	P0C874
PQSPFPALPPSPLFL	SPATA31D3	581	P0C874
SFQFQPPLPPDTPPL	ZCCHC8	461	Q6NZY4
LPTPVPPPLAPAQLR	ZBTB45	136	Q96K62
FISGLPFLSPPPPPL	ZFHX2	1316	Q9C0A1
PFLSPPPPPLDLHRF	ZFHX2	1321	Q9C0A1
PPPPLDLHRFPAPLF	ZFHX2	1326	Q9C0A1
LPLEHPSPEPPALFP	SPATA31A1	191	Q5TZJ5
PPPFTLSLPLVPPRS	SPEM3	591	A0A1B0GUW6
LLEPPALPSPLRPPA	SLC2A4RG	281	Q9NR83
LPLEHPSPEPPALFP	SPATA31A5	191	Q5VU36
LFSPSPLRDPLPPQP	SPATA31D1	211	Q6ZQQ2
PLRDPLPPQPVSPLD	SPATA31D1	216	Q6ZQQ2
PPEFPLPPATRITPN	PRO2289	36	Q9P1D8
LPPSLFQAPPLPLQP	HIVEP3	1181	Q5T1R4
PPAPLTSRALPPEPA	SEMA6C	786	Q9H3T2
PDPPAPFTPSPLPRL	SEZ6	96	Q53EL9
PLPPTPSRALDDKPP	WIPF1	251	O43516
APLLSPRPSQPEPPH	VPS37D	236	Q86XT2
PTPPPPPRRSLSLLD	SOCS7	306	O14512
QPPSPLLLLPPQPDE	SKOR2	671	Q2VWA4
LEPLTLAPAPAPRPP	SYMPK	1121	Q92797
PRPPFLYPGPPLSLQ	ZNF843	216	Q8N446
LRCSRLPPPPPLPLL	ZNRF3	26	Q9ULT6
LPPRLPELAPTAPLP	VPS37B	176	Q9H9H4
LLEPVPSSPLQPLPP	PRR23C	221	Q6ZRP0
SHPPQRLPKPLPLSP	XIRP1	1336	Q702N8
PLPNPPPEVFPALDS	UBQLN3	571	Q9H347
PLSLAPPPLPLPAAA	ZBTB22	16	O15209
RLSPPPEELPASPLP	KMT2D	466	O14686
RNFPLPLPNKPRPPS	LCP2	396	Q13094
VQLPRLALSPPPPAP	MYPOP	211	Q86VE0