Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncarnitine O-palmitoyltransferase activity

CPT1C CPT1A CPT1B

8.62e-104133GO:0004095
GeneOntologyMolecularFunctionO-palmitoyltransferase activity

CPT1C CPT1A CPT1B

2.15e-095133GO:0016416
GeneOntologyMolecularFunctioncarnitine O-acyltransferase activity

CPT1C CPT1A CPT1B

4.31e-096133GO:0016406
GeneOntologyMolecularFunctionpalmitoyltransferase activity

CPT1C HHAT CPT1A CPT1B

7.05e-0937134GO:0016409
GeneOntologyMolecularFunctionO-acyltransferase activity

CPT1C HHAT CPT1A CPT1B

4.82e-0859134GO:0008374
GeneOntologyMolecularFunctionacyltransferase activity, transferring groups other than amino-acyl groups

CPT1C HHAT CPT1A CPT1B

1.29e-05238134GO:0016747
GeneOntologyMolecularFunctionacyltransferase activity

CPT1C HHAT CPT1A CPT1B

1.22e-03775134GO:0016746
GeneOntologyBiologicalProcesscarnitine metabolic process

CPT1C CPT1A CPT1B

5.57e-0813133GO:0009437
GeneOntologyBiologicalProcessamino-acid betaine metabolic process

CPT1C CPT1A CPT1B

1.59e-0718133GO:0006577
GeneOntologyBiologicalProcesscarnitine shuttle

CPT1A CPT1B

2.20e-064132GO:0006853
GeneOntologyBiologicalProcessfatty acid transmembrane transport

CPT1A CPT1B

8.41e-0522132GO:1902001
GeneOntologyBiologicalProcessmodified amino acid metabolic process

CPT1C CPT1A CPT1B

3.08e-04218133GO:0006575
GeneOntologyBiologicalProcessintracellular lipid transport

CPT1A CPT1B

4.96e-0453132GO:0032365
HumanPhenoIncreased skull ossification

HHAT NAGLU

7.53e-045842HP:0004330
DomainCPT_N

CPT1C CPT1A CPT1B

2.63e-103133IPR032476
DomainCPT_N

CPT1C CPT1A CPT1B

2.63e-103133PF16484
DomainCarn_acyltransf

CPT1C CPT1A CPT1B

9.21e-097133PF00755
DomainACYLTRANSF_C_1

CPT1C CPT1A CPT1B

9.21e-097133PS00439
DomainCarn_acyl_trans

CPT1C CPT1A CPT1B

9.21e-097133IPR000542
DomainACYLTRANSF_C_2

CPT1C CPT1A CPT1B

9.21e-097133PS00440
PathwayKEGG_MEDICUS_REFERENCE_BETA_OXIDATION_ACYL_COA_SYNTHESIS

CPT1C CPT1A CPT1B

1.24e-081173M47626
PathwayKEGG_FATTY_ACID_METABOLISM

CPT1C CPT1A CPT1B

8.54e-074273M699
PathwayPID_HNF3B_PATHWAY

CPT1C CPT1A CPT1B

1.05e-064573M106
PathwayWP_AMPACTIVATED_PROTEIN_KINASE_SIGNALING

CPT1C CPT1A CPT1B

3.54e-066773M39630
PathwayKEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY

CPT1C CPT1A CPT1B

3.54e-066773M10462
PathwayWP_PPAR_SIGNALING

CPT1C CPT1A CPT1B

3.54e-066773M39553
PathwayKEGG_PPAR_SIGNALING_PATHWAY

CPT1C CPT1A CPT1B

3.87e-066973M13088
PathwayWP_PPAR_SIGNALING_PATHWAY

CPT1C CPT1A CPT1B

4.59e-067373MM15995
PathwayWP_THERMOGENESIS

CPT1C CPT1A CPT1B

1.50e-0510873M39746
PathwayREACTOME_CARNITINE_METABOLISM

CPT1A CPT1B

1.92e-051472MM14788
PathwayREACTOME_CARNITINE_METABOLISM

CPT1A CPT1B

1.92e-051472M27098
PathwayWP_FATTY_ACID_BETAOXIDATION

CPT1A CPT1B

1.18e-043472M39596
PathwayWP_FATTY_ACID_BETAOXIDATION

CPT1A CPT1B

1.18e-043472MM15937
PathwayREACTOME_SIGNALING_BY_RETINOIC_ACID

CPT1A CPT1B

1.89e-044372M27443
PathwayREACTOME_SIGNALING_BY_RETINOIC_ACID

CPT1A CPT1B

2.46e-044972MM15186
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

CPT1C CPT1A CPT1B

6.32e-0438173M48063
PathwayREACTOME_FATTY_ACID_METABOLISM

CPT1A CPT1B

2.92e-0317072MM15573
PathwayREACTOME_FATTY_ACID_METABOLISM

CPT1A CPT1B

3.12e-0317672M27854
PathwayREACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS

CPT1A CPT1B

3.67e-0319172MM15586
PathwayWP_CIRCADIAN_RHYTHM_GENES

NAGLU CPT1A

4.05e-0320172M39605
PathwayREACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS

CPT1A CPT1B

8.61e-0329672M27869
Pubmed

Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity.

CPT1C CPT1A CPT1B

2.08e-10414311095714
Pubmed

The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions.

CPT1C CPT1A CPT1B

2.08e-10414326041663
Pubmed

Genomics of the human carnitine acyltransferase genes.

CPT1C CPT1A CPT1B

1.04e-09614311001805
Pubmed

Temperature dependence of the control of energy homeostasis requires CART signaling.

CPT1C CPT1A CPT1B

1.14e-081214327080622
Pubmed

Nutrient Transporter Gene Expression in the Early Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy.

CPT1C CPT1A CPT1B

1.19e-072514335478964
Pubmed

Fine chromosome mapping of the genes for human liver and muscle carnitine palmitoyltransferase I (CPT1A and CPT1B).

CPT1A CPT1B

1.50e-0721429070950
Pubmed

Variants within the muscle and liver isoforms of the carnitine palmitoyltransferase I (CPT1) gene interact with fat intake to modulate indices of obesity in French-Canadians.

CPT1A CPT1B

1.50e-07214217089095
Pubmed

Expression and regulation of carnitine palmitoyltransferase-Ialpha and -Ibeta genes.

CPT1A CPT1B

1.50e-07214210408760
Pubmed

Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis.

CPT1A CPT1B

1.50e-0721429013572
Pubmed

High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism.

CPT1C CPT1A

4.51e-07314224618825
Pubmed

Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues.

CPT1A CPT1B

4.51e-07314211023836
Pubmed

Carnitine palmitoyltransferase I and Acyl-CoA dehydrogenase 9 in retina: insights of retinopathy in mitochondrial trifunctional protein defects.

CPT1C CPT1A

4.51e-07314218385088
Pubmed

Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene.

CPT1A CPT1B

4.51e-0731428307575
Pubmed

Haplotype analysis of carnitine transporters and left ventricular mass in human essential hypertension.

CPT1A CPT1B

9.02e-07414215647998
Pubmed

Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction.

CPT1A CPT1B

9.02e-07414226253087
Pubmed

Increased expression of carnitine palmitoyltransferase I gene is repressed by administering L-carnitine in the hearts of carnitine-deficient juvenile visceral steatosis mice.

CPT1A CPT1B

9.02e-0741428830050
Pubmed

HIV-1 Vpr enhances PPARβ/δ-mediated transcription, increases PDK4 expression, and reduces PDC activity.

CPT1A CPT1B

3.16e-06714223842279
Pubmed

Molecular enzymology of carnitine transfer and transport.

CPT1A CPT1B

5.41e-06914211257506
Pubmed

Maternal diabetes causes coordinated down-regulation of genes involved with lipid metabolism in the murine fetal heart.

CPT1A CPT1B

1.37e-051414218502258
Pubmed

Chromosomal locations of the mouse fatty acid oxidation genes Cpt1a, Cpt1b, Cpt2, Acadvl, and metabolically related Crat gene.

CPT1A CPT1B

2.04e-05171429680378
Pubmed

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.

CPT1A CPT1B

2.29e-051814216054041
Pubmed

Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism.

CPT1A CPT1B

5.25e-052714224086110
Pubmed

Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming.

CPT1A CPT1B

5.65e-052814228159809
Pubmed

Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation.

CPT1A CPT1B

2.21e-045514227997827
Pubmed

Candidate gene polymorphisms for ischemic stroke.

C1orf167 PARP12

2.99e-046414219729601
InteractionGORASP1 interactions

MON2 FCGRT FLOT2

3.57e-05103133int:GORASP1
CytobandEnsembl 112 genes in cytogenetic band chr17q11

SUPT6H FLOT2

1.22e-03171142chr17q11
CoexpressionJOHNSTONE_PARVB_TARGETS_3_UP

SUPT6H FLOT2 PARP12 NAGLU

6.45e-05433144M2240
CoexpressionMOOTHA_FFA_OXYDATION

CPT1A CPT1B

7.26e-0524142M15531
CoexpressionZHAN_V1_LATE_DIFFERENTIATION_GENES_UP

FCGRT NAGLU

1.39e-0433142M13608
CoexpressionGSE35543_IN_VITRO_ITREG_VS_CONVERTED_EX_ITREG_UP

FCGRT HHAT PARP12

1.50e-04200143M9437
CoexpressionGSE17721_CTRL_VS_GARDIQUIMOD_0.5H_BMDC_UP

SUPT6H PARP12 CPT1A

1.50e-04200143M3774
CoexpressionGSE369_PRE_VS_POST_IL6_INJECTION_SOCS3_KO_LIVER_DN

FCGRT SUPT6H NAGLU

1.50e-04200143M5977
DrugTDGA-carnitine

CPT1C CPT1A CPT1B

1.45e-095133CID000196388
Drug4 t ha

CPT1C CPT1A CPT1B

1.45e-095133CID000124503
Drugbezafibroyl CoA

CPT1C CPT1A CPT1B

1.45e-095133CID000176137
DrugTG-CoA

CPT1C CPT1A CPT1B

2.91e-096133CID000124781
Drugpisolithin A

CPT1C CPT1A CPT1B

2.91e-096133CID000000355
DrugFOX 988

CPT1C CPT1A CPT1B

2.91e-096133CID005491458
DrugPDCoA

CPT1C CPT1A CPT1B

2.91e-096133CID000125034
Drugmethylthiopropionylcarnitine

CPT1C CPT1A CPT1B

8.13e-098133CID000194919
DrugAC1O5S5Y

CPT1C CPT1A CPT1B

8.13e-098133CID006439672
Drug3-acetamido-4-trimethylaminobutyric acid

CPT1C CPT1A CPT1B

1.22e-089133CID000127169
Drug2-bromododecanoate

CPT1C CPT1A CPT1B

1.74e-0810133CID000066980
Druglinoleylcarnitine

CPT1C CPT1A CPT1B

1.74e-0810133CID006450015
Drugetomoxiryl-CoA

CPT1C CPT1A CPT1B

3.19e-0812133CID003081714
Drug4-Cphoc

CPT1C CPT1A CPT1B

4.15e-0813133CID000001230
Drugclomoxir

CPT1C CPT1A CPT1B

5.27e-0814133CID000054221
Drug2-tetradecylglycidic acid

CPT1C CPT1A CPT1B

5.27e-0814133CID000071976
Drugoleoylcarnitine

CPT1C CPT1A CPT1B

8.11e-0816133CID006441392
Drugbuformin

CPT1C CPT1A CPT1B

1.18e-0718133CID000002468
Drugaminocarnitine

CPT1C CPT1A CPT1B

1.65e-0720133CID000121830
Drug4-bromocrotonic acid

CPT1C CPT1A CPT1B

1.65e-0720133CID006436411
DrugAD 198

CPT1C CPT1A CPT1B

1.65e-0720133CID000127201
Drugoxfenicine

CPT1C CPT1A CPT1B

2.56e-0723133CID000036143
Drugbeta-aminoisobutyric acid

CPT1C CPT1A CPT1B

2.92e-0724133CID000064956
DrugPOCA

CPT1C CPT1A CPT1B

3.75e-0726133CID000054217
Drugmethyl palmoxirate

CPT1C CPT1A CPT1B

3.75e-0726133CID000068593
Drughydroxycitrate

CPT1C CPT1A CPT1B

3.75e-0726133CID000123908
DrugAC1L3NLD

CPT1C CPT1A CPT1B

5.27e-0729133CID000092184
Drugoctanoylcarnitine

CPT1C CPT1A CPT1B

5.85e-0730133CID000123701
Drughexadecanedioic acid

CPT1C CPT1A CPT1B

7.86e-0733133CID000010459
Drug2-bromopalmitoylcarnitine

CPT1C CPT1A

9.03e-073132CID003082365
DrugCETTD

CPT1C CPT1A CPT1B

1.12e-0637133CID000150912
Drugpropionyl-L-carnitine

CPT1C CPT1A CPT1B

1.21e-0638133CID000107738
DrugBCMTD

CPT1C CPT1A CPT1B

1.31e-0639133CID000161757
Druggamma-butyrobetaine

CPT1C CPT1A CPT1B

1.65e-0642133CID000000134
Drugoctylglucopyranoside

FLOT2 CPT1C CPT1A CPT1B

1.72e-06163134CID000062080
Drugdecanoyl-CoA

CPT1C CPT1A CPT1B

1.77e-0643133CID000164800
DrugHCFC 225ca

CPT1C CPT1A

1.80e-064132CID000061112
DrugR225A

CPT1C CPT1A

1.80e-064132CID000062353
Drugpalmitoylcholine

CPT1C CPT1A

1.80e-064132CID000151731
DrugTDGA

CPT1C CPT1A CPT1B

2.32e-0647133CID000031277
DrugNSC640330

CPT1C CPT1A CPT1B

2.48e-0648133CID000005204
Drugperhexiline

CPT1C CPT1A CPT1B

4.41e-0658133CID000004746
DrugAC1L2K2J

CPT1C CPT1A

4.51e-066132CID000073552
DrugME(O)HP

CPT1C CPT1A

4.51e-066132CID000119096
DrugNSC 88147

CPT1C CPT1A

4.51e-066132CID000258814
Drug3-Hydroxy-5,5-dimethylhexanoic acid

CPT1C CPT1A

4.51e-066132CID000192450
DrugAC1L2UAM

CPT1C CPT1A

4.51e-066132CID000128706
Drug3-amino-5,5-dimethylhexanoic acid

CPT1C CPT1A

4.51e-066132CID010397086
DrugAC1L1AH5

MON2 CPT1C CPT1A CPT1B

5.17e-06215134CID000000986
Drugpristanic acid

CPT1C CPT1A CPT1B

5.94e-0664133CID000123929
DrugAC1L193Y

CPT1C CPT1A CPT1B

6.22e-0665133CID000000380
Drug2-bromopalmitate

CPT1C CPT1A CPT1B

6.52e-0666133CID000082145
Drug3-hydroxy-3-methylglutaryl-CoA

MON2 CPT1C CPT1A CPT1B

7.60e-06237134CID000000084
Drugmyristoylcarnitine

CPT1C CPT1A

8.41e-068132CID003413344
DrugUK5099

CPT1C CPT1A

8.41e-068132CID006438504
DrugAD-143

CPT1C CPT1A

8.41e-068132CID000333663
DrugNSC-163661

CPT1C CPT1A CPT1B

9.59e-0675133CID000005155
Drug9,10-epoxystearic acid

MON2 CPT1A

1.08e-059132CID000015868
Drugmethylmalonyl-CoA

CPT1C CPT1A CPT1B

1.12e-0579133CID000000613
Drugacetyl-L-carnitine

CPT1C CPT1A CPT1B

1.35e-0584133CID000000001
Drugstearoylcarnitine

CPT1C CPT1A

1.35e-0510132CID000005282
Drug6-aminohexanol

CPT1C CPT1A

1.35e-0510132CID000019960
Drugniadenate

CPT1C CPT1A

1.35e-0510132CID000181712
DrugKCD-232

CPT1C CPT1A

1.35e-0510132CID000124998
DrugWy-14,643

MON2 CPT1C CPT1A CPT1B

1.59e-05286134CID000005694
DrugAC1L1COZ

CPT1C CPT1A CPT1B

1.66e-0590133CID000001996
Drug5,6,7-trimethoxyflavone

CPT1C CPT1A

1.98e-0512132CID000442583
DrugS-(4-bromo-2,3-dioxobutyl)-CoA

CPT1C CPT1A

1.98e-0512132CID000188365
Drugphytanic acid

CPT1C CPT1A CPT1B

2.01e-0596133CID000026840
DrugTween 20

CPT1C CPT1A CPT1B

2.14e-0598133CID000443314
DrugS-(-)-Etomoxir

CPT1C CPT1A CPT1B

2.28e-05100133CID000060765
Drugpalmitoylcarnitine

CPT1C CPT1A CPT1B

2.42e-05102133CID000000461
DrugAND-CoA

CPT1C CPT1A CPT1B

2.79e-05107133CID003083159
Drugerucyl-CoA

CPT1C CPT1A

3.15e-0515132CID006443765
DrugZ-15

CPT1C CPT1A

3.60e-0516132CID000477539
Drugoleoyl coenzyme A

CPT1C CPT1A CPT1B

3.74e-05118133CID000000966
Drugcitric acid

CPT1C PARP12 CPT1A CPT1B

3.80e-05357134CID000000311
Drugproglycosyn

CPT1C CPT1A

4.07e-0517132CID000147052
Drugstearoyl-coenzyme A

CPT1C CPT1A CPT1B

4.13e-05122133CID000001106
Drugacetoacetate

CPT1C CPT1A CPT1B

4.13e-05122133CID000000096
Drugacadesine

CPT1C CPT1A CPT1B

4.55e-05126133CID000017513
Drug3,4-dioctylphthalic acid

CPT1C CPT1A CPT1B

4.55e-05126133CID005743034
Drugmalonyl-coenzyme A

CPT1C CPT1A CPT1B

4.55e-05126133CID000000869
Drugperfluorobutane

CPT1A CPT1B

4.58e-0518132ctd:C108042
DrugEPA-CoA

CPT1C CPT1A

4.58e-0518132CID006450079
Drugtetradecylthioacetic acid

CPT1C CPT1A CPT1B

4.76e-05128133CID000114924
DrugAC1Q68Z5

CPT1C NAGLU CPT1A CPT1B

5.15e-05386134CID000000181
Drug9,11-octadecadienoic acid

CPT1C CPT1A CPT1B

6.49e-05142133CID000074607
DrugAC1L1FF5

CPT1C CPT1A CPT1B

8.74e-05157133CID000003209
Drug5,5'-dithiobis(2-nitrobenzoic acid

CPT1C CPT1A CPT1B

8.74e-05157133CID000006254
Drugglycogen

CPT1C NAGLU CPT1A CPT1B

8.79e-05443134CID000439177
DrugGW 7647

CPT1A CPT1B

8.96e-0525132ctd:C453899
DrugAC1Q5SQW

FLOT2 CPT1B

8.96e-0525132CID000003912
DrugAICAR monophosphate

CPT1C CPT1A CPT1B

9.77e-05163133CID000000200
Drugn-propionyl-CoA

CPT1C CPT1A CPT1B

1.03e-04166133CID000001033
DrugAC1L9NBB

CPT1C CPT1A CPT1B

1.09e-04169133CID000449615
Drugciprofibrate

CPT1C CPT1A CPT1B

1.11e-04170133CID000002763
Drugbeta-hydroxybutyrate

CPT1C CPT1A CPT1B

1.29e-04179133CID000000441
Drugoctanoate

CPT1C CPT1A CPT1B

1.33e-04181133CID000000379
DrugRaloxifene hydrochloride [82640-04-8]; Down 200; 7.8uM; MCF7; HT_HG-U133A

FLOT2 CPT1A CPT1B

1.49e-041881333480_DN
DiseaseAlloxan Diabetes

CPT1A CPT1B

1.17e-03108142C0002152
DiseaseStreptozotocin Diabetes

CPT1A CPT1B

1.17e-03108142C0038433
DiseaseDiabetes Mellitus, Experimental

CPT1A CPT1B

1.17e-03108142C0011853
Diseaseserum non-albumin protein measurement

FCGRT CPT1C

1.23e-02361142EFO_0004568
Diseasecortical thickness

MON2 FLOT2 HHAT

1.43e-021113143EFO_0004840

Protein segments in the cluster

PeptideGeneStartEntry
GAQAAQCWTWCWALW

C1orf167

1131

Q5SNV9
QYVFGGWAWAWWCIS

FLOT2

26

Q14254
GWAWAWWCISDTQRI

FLOT2

31

Q14254
WWATNYVSDWWEEYI

CPT1A

226

P50416
CTQSYSFVWWDWARW

NAGLU

136

P54802
CGAWVWENQVSWYWE

FCGRT

71

P55899
WNWDTWDGPEQEGDW

KRI1

426

Q8N9T8
DLNLWWAAWNTWYRI

MON2

1236

Q7Z3U7
DWIWYWSDEFGSWQE

PARP12

376

Q9H0J9
TDFEWSFWMEWGKQW

HHAT

56

Q5VTY9
WWASNYVSDWWEEFV

CPT1C

226

Q8TCG5
EERTWDWCWMAQWVT

PRSS51

116

A0A1B0GVH4
KSWWASNYVSDWWEE

CPT1B

226

Q92523
NDLWRVWQWDEKWTQ

SUPT6H

391

Q7KZ85
VVQLSWSWEAWWQAA

TMEM169

231

Q96HH4