Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9

4.56e-1237256GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9

5.41e-1238256GO:0070001
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9

1.21e-05430256GO:0004175
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-8 ERVK-6 OAS3 POLR3G

3.60e-05152254GO:0016779
GeneOntologyMolecularFunctionstructural molecule activity

ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9 PLEC

8.16e-05891257GO:0005198
GeneOntologyMolecularFunctionzinc ion binding

ERVK-8 ERVK-6 ERVK-19 KDM5B TRIM11 ERVK-21 ERVK-9

8.16e-05891257GO:0008270
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-8 ERVK-6

8.22e-0511252GO:0004523
GeneOntologyMolecularFunctionpeptidase activity

ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9

1.25e-04654256GO:0008233
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-8 ERVK-6

1.36e-0414252GO:0003964
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-8 ERVK-6

3.11e-0421252GO:0035613
GeneOntologyMolecularFunctiontransition metal ion binding

ERVK-8 ERVK-6 ERVK-19 KDM5B TRIM11 ERVK-21 ERVK-9

4.85e-041189257GO:0046914
GeneOntologyMolecularFunctionendonuclease activity

ERVK-8 ERVK-6 OGG1

6.37e-04136253GO:0004519
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-8 ERVK-6

9.76e-0437252GO:0016891
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-8 ERVK-6

1.03e-0338252GO:0034061
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-8 ERVK-6

1.51e-0346252GO:0016893
GeneOntologyMolecularFunctionnuclease activity

ERVK-8 ERVK-6 OGG1

2.91e-03231253GO:0004518
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

ERVK-8 ERVK-6 OGG1

4.15e-03262253GO:0140097
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-8 ERVK-6

4.37e-0379252GO:0004521
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

ERVK-8 ERVK-6 OGG1 POLR3G

7.95e-03645254GO:0140640
GeneOntologyBiologicalProcesscell-cell fusion

ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9

6.48e-0885265GO:0140253
GeneOntologyBiologicalProcesssyncytium formation by plasma membrane fusion

ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9

6.48e-0885265GO:0000768
GeneOntologyBiologicalProcessviral process

ERVK-8 ERVK-6 OAS3 ERVK-19 TRIM11 ERVK-21 ERVK-9 CD28

6.76e-08464268GO:0016032
GeneOntologyBiologicalProcesssyncytium formation

ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9

8.18e-0889265GO:0006949
GeneOntologyBiologicalProcesspositive regulation of interferon-beta production

OAS3 TRIM11 POLR3G

2.78e-0547263GO:0032728
GeneOntologyBiologicalProcessinterferon-beta production

OAS3 TRIM11 POLR3G

1.04e-0473263GO:0032608
GeneOntologyBiologicalProcessregulation of interferon-beta production

OAS3 TRIM11 POLR3G

1.04e-0473263GO:0032648
GeneOntologyBiologicalProcessDNA integration

ERVK-8 ERVK-6

1.18e-0413262GO:0015074
GeneOntologyBiologicalProcesspositive regulation of type I interferon production

OAS3 TRIM11 POLR3G

1.42e-0481263GO:0032481
GeneOntologyBiologicalProcesspositive regulation of gene expression

ERVK-6 OAS3 KDM5B SH3PXD2B TRIM11 OGG1 CD28 POLR3G

2.85e-041446268GO:0010628
DomainDEP

RGS11 RAPGEF4

2.00e-0422182PF00610
DomainDEP

RGS11 RAPGEF4

2.00e-0422182SM00049
DomainDEP

RGS11 RAPGEF4

2.00e-0422182PS50186
DomainDEP_dom

RGS11 RAPGEF4

2.19e-0423182IPR000591
Domain-

RGS11 RAPGEF4

1.83e-022181821.10.10.10
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9

1.22e-131226514557543
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9 ERVK-16

5.29e-139426721542922
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-19 ERVK-9 ERVK-16

3.68e-12626415063128
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-19 ERVK-21

3.70e-09526312629516
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-19 ERVK-21

4.43e-081026312970426
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-21 ERVK-25 ERVK-9

3.00e-071826318664271
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

5.37e-0722629060628
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

5.37e-0722629460924
Pubmed

Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.

ERVK-6 ERVK-19

1.61e-06326210516026
Pubmed

Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.

ERVK-6 ERVK-9

1.61e-0632629971820
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-19

3.22e-0642627983737
Pubmed

Tempo and mode of ERV-K evolution in human and chimpanzee genomes.

ERVK-6 ERVK-16

5.37e-06526216830071
Pubmed

Card9 protects fungal peritonitis through regulating Malt1-mediated activation of autophagy in macrophage.

OAS3 PLEC

3.53e-051226235850054
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

CCP110 KDM5B SH3PXD2B PLEC SHTN1

3.92e-0486126536931259
Pubmed

High-Confidence Interactome for RNF41 Built on Multiple Orthogonal Assays.

CCP110 SHTN1

6.44e-045026229560723
CoexpressionAtlasgamma delta T cells, Tgd.vg2-.Sp, TCRd+ Vg2- CD44-, Spleen, avg-3

OAS3 KDM5B PLEC CD28 RAPGEF4

1.73e-05382195GSM476684_500
CoexpressionAtlasgamma delta T cells, Tgd.vg2-.Sp.TCRbko, TCRd+ Vg2- CD44-, Spleen, avg-3

OAS3 KDM5B PLEC CD28 RAPGEF4

2.30e-05405195GSM605796_500
CoexpressionAtlasdev gonad_e13.5_M_SertoliCell_Sox9_top-relative-expression-ranked_1000

KDM5B RGS11 PLEC SHTN1 RAPGEF4 POLR3G

8.49e-05880196gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_1000
CoexpressionAtlasalpha beta T cells, T.4int8+.Th, 4int 8+ TCRhi, Thymus, avg-3

OAS3 KDM5B CD28 RAPGEF4

1.11e-04289194GSM399367_500
CoexpressionAtlasalpha beta T cells, T.4SP24int.Th, 4+ 8- TCRhi 24int, Thymus, avg-3

OAS3 KDM5B CD28 RAPGEF4

1.72e-04324194GSM399373_500
CoexpressionAtlasalpha beta T cells, T.8SP24int.Th, 4- 8+ TCRhi 24int, Thymus, avg-3

OAS3 KDM5B CD28 RAPGEF4

2.05e-04339194GSM399382_500
CoexpressionAtlasalpha beta T cells, T.8SP69+.Th, 4- 8+ TCRhi 69+, Thymus, avg-3

OAS3 KDM5B CD28 RAPGEF4

2.63e-04362194GSM399385_500
CoexpressionAtlasalpha beta T cells, T.4SP24-.Th, 4+ 8- TCRhi 24-/lo, Thymus, avg-3

OAS3 KDM5B CD28 RAPGEF4

2.71e-04365194GSM399370_500
CoexpressionAtlasalpha beta T cells, T.4SP69+.Th, 4+ 8- TCRhi 69+, Thymus, avg-3

OAS3 KDM5B CD28 RAPGEF4

2.71e-04365194GSM399376_500
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_k-means-cluster#2_top-relative-expression-ranked_500

CCP110 UTP18 POLR3G

3.20e-04152193gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_k2_500
CoexpressionAtlasgamma delta T cells, Tgd.vg2+.Sp, TCRd+ Vg2+ CD44-, Spleen, avg-3

OAS3 KDM5B CD28 RAPGEF4

3.36e-04386194GSM605787_500
CoexpressionAtlasgamma delta T cells, Tgd.vg2+.Sp.TCRbko, TCRd+ Vg2+ CD44-, Spleen, avg-3

OAS3 KDM5B CD28 RAPGEF4

3.42e-04388194GSM605790_500
CoexpressionAtlasdev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_1000

SH3BP1 CCP110 UTP18 SHTN1 POLR3G

6.35e-04822195gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_1000
CoexpressionAtlasCD positive, CD4 Control, 4+ 8- B220-, Spleen, avg-4

CD28 RAPGEF4

8.01e-0447192GSM403995_100
CoexpressionAtlasdev gonad_e12.5_M_SertoliCell_Sox9_top-relative-expression-ranked_1000

KDM5B RGS11 SHTN1 RAPGEF4 POLR3G

8.83e-04884195gudmap_dev gonad_e12.5_M_SertoliCell_Sox9_1000
CoexpressionAtlasalpha beta T cells, T.4Nve.LN, 4+ 8- 25- 62Lhi 44lo, Lymph Node, avg-3

CD28 RAPGEF4

9.42e-0451192GSM538374_100
CoexpressionAtlasalpha beta T cells, T.4Nve.MLN, 4+ 8- 25- 62Lhi 44lo, Lymph Node, avg-3

CD28 RAPGEF4

9.79e-0452192GSM538377_100
CoexpressionAtlasalpha beta T cells, T.8SP24int.Th, 4- 8+ TCRhi 24int, Thymus, avg-3

CD28 RAPGEF4

9.79e-0452192GSM399382_100
CoexpressionAtlasalpha beta T cells, T.4Nve.PP, TCR+ CD4+ CD44low CD62Lhigh, Peyer's Patch, avg-2

CD28 RAPGEF4

1.02e-0353192GSM538380_100
CoexpressionAtlasalpha beta T cells, T.4Nve.Sp, 4+ 8- 25- 62Lhi 44lo, Spleen, avg-4

CD28 RAPGEF4

1.06e-0354192GSM538382_100
CoexpressionAtlasalpha beta T cells, T.4int8+.Th, 4int 8+ TCRhi, Thymus, avg-3

CD28 RAPGEF4

1.06e-0354192GSM399367_100
CoexpressionAtlasCD positive, CD4 Test CJ, 4+8-B220-, Spleen, avg-2

CD28 RAPGEF4

1.10e-0355192GSM404003_100
CoexpressionAtlasCD positive, CD4 Control, 4+8-B220-, Spleen, avg-2

CD28 RAPGEF4

1.10e-0355192GSM403994_100
CoexpressionAtlasCD positive, CD4 Test NA, 4+8-B220-, Spleen, avg-1

CD28 RAPGEF4

1.13e-0356192GSM403986_100
CoexpressionAtlasCD positive, CD4 Test DB, 4+8-B220-, Spleen, avg-1

CD28 RAPGEF4

1.22e-0358192GSM403987_100
CoexpressionAtlasalpha beta T cells, T.8SP69+.Th, 4- 8+ TCRhi 69+, Thymus, avg-3

CD28 RAPGEF4

1.22e-0358192GSM399385_100
CoexpressionAtlasalpha beta T cells, T.4FP3-.Sp, 4+ 8- GFP- 44lo, Spleen, avg-3

CD28 RAPGEF4

1.26e-0359192GSM605766_100
CoexpressionAtlasalpha beta T cells, T.8SP24-.Th, 4- 8+ TCRhi 24-/lo, Thymus, avg-3

OAS3 RAPGEF4

1.30e-0360192GSM399379_100
CoexpressionAtlasCD positive, CD4 Test JS, 4+8-B220-, Spleen, avg-3

CD28 RAPGEF4

1.35e-0361192GSM404000_100
CoexpressionAtlasalpha beta T cells, T.8Mem.LN, CD8 TCRb CD44high CD122high, Lymph Node, avg-3

CD28 RAPGEF4

1.39e-0362192GSM538395_100
CoexpressionAtlasalpha beta T cells, T.8Mem.Sp, 4- 8+ 25- 44hi 122hi, Spleen, avg-3

CD28 RAPGEF4

1.48e-0364192GSM538398_100
CoexpressionAtlasalpha beta T cells, T.8.Sp.B16, 4- 8+ TCR+ 45+, B16 Melanoma Spleen, avg-3

CD28 RAPGEF4

1.57e-0366192GSM605770_100
CoexpressionAtlasCD positive, T.8Nve.Sp.OT1, CD8+ CD45.1+, Spleen, avg-3

CD28 RAPGEF4

1.77e-0370192GSM605909_100
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHTN1 TSGA10IP PNOC

3.59e-05153193c81a88d3f707487c511020d3960a1c41e706c6a0
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

OAS3 KDM5B CD28

4.74e-05168193ca94b29c1030484143a77f2df06dad74d2c6136e
ToppCelldroplet-Thymus-nan-18m-Lymphocytic-DN4|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OAS3 RGS11 CD28

5.00e-05171193f08402d0f42822c35673522043b652f8fb68d2f6
ToppCellfacs-Marrow-KLS-18m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SH3BP1 SH3PXD2B SHTN1

5.09e-05172193979fd7b435f59b8a4d290a809cf76147d4c63d48
ToppCellfacs-Marrow-KLS-18m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SH3BP1 SH3PXD2B SHTN1

5.09e-05172193f4d7f416802218ce56408fa4cb8a555d846bc85b
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD141+_DCs|Myeloid_cells / Location, Cell class and cell subclass

RGS11 SHTN1 PNOC

5.82e-05180193a0b35067b6f2dbd8145da8bab760e9f650f045b0
ToppCell10x5'-GI_small-bowel-Myeloid_Dendritic-DC2|GI_small-bowel / Manually curated celltypes from each tissue

SH3PXD2B SHTN1 RAPGEF4

6.31e-05185193f78be85dd6e443abb7af20f98ff351c1131ece4d
ToppCellMesenchymal_cells-Ng2+_MSCs|Mesenchymal_cells / Lineage and Cell class

SH3PXD2B CD28 RAPGEF4

6.52e-05187193e899b906409f3fad69cb3d3c6432c3fd862ae3c1
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Myeloid|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

SH3BP1 OAS3 SHTN1

7.61e-05197193179b56147cfb0a5f53c58615f2612b8ef68c8bb8
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-leukocyte|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PLEC CD28 RAPGEF4

7.61e-05197193d968d7d5608b175bb567ea3a315bf473ec3be459
ToppCellLPS_IL1RA_TNF-Hematopoietic_Myeloid-Dendritic_cells|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SHTN1 TSGA10IP PNOC

7.72e-05198193436f3a9ef31b0991765bb97c21960f20fa71d578
ToppCellControl-Control-Lymphocyte-T/NK-CD4+_T_activated|Control / Disease, condition lineage and cell class

OAS3 CD28 RAPGEF4

7.72e-05198193ee71543559836fd59adc0da877b2ca538cba60cb
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.

RGS11 PLEC AJAP1

7.96e-0520019361d7dd0a78942b069c3f5e75044368dc00e6e8e6
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

RGS11 PLEC AJAP1

7.96e-052001935c7263c862093ad9dbc81d06b16b6f74e8a6b634
Diseasecorpus callosum volume measurement

PLEC SHTN1

2.08e-03100202EFO_0010299
DiseaseHIV Coinfection

OGG1 CD28

2.20e-03103202C4505456
DiseaseHIV Infections

OGG1 CD28

2.20e-03103202C0019693
Diseasewhite matter microstructure measurement

PLEC SHTN1 CD28

2.21e-03390203EFO_0005674
Diseasebreast cancer (is_implicated_in)

KDM5B OGG1

4.59e-03150202DOID:1612 (is_implicated_in)
Diseasemultiple sclerosis

PLEC TSGA10IP CD28

7.17e-03594203MONDO_0005301
Diseasebody surface area

UTP18 PLEC SHTN1

8.91e-03643203EFO_0022196
Diseasetonsillectomy risk measurement

SH3PXD2B AJAP1

1.32e-02260202EFO_0007924

Protein segments in the cluster

PeptideGeneStartEntry
MNPSEMQRKAPPRRR

ERVK-25

1

P61579
MNPSEMQRKAPPRRR

ERVK-19

1

O71037
MNPSEMQRKAPPRRR

ERVK-8

1

Q902F8
MNPSEMQRKAPPRRR

ERVK-9

1

Q9UKH3
YMNMTPRRPGPTRKH

CD28

191

P10747
MARRTKRPAPARPTM

SH3BP1

561

Q9Y3L3
GQMQMPRARRAHRPR

AJAP1

91

Q9UKB5
MNPSEMQRKAPPRRR

HERVK_113

1

P61574
MNPSEMQRKAPPRRR

HERV-K104

1

P61576
MNPSEMQRKAPPRRR

ERVK-16

1

P61578
MNPSEMQRKAPPRRR

ERVK-19

1

P61572
MHPSEMQRKAPPRRR

ERVK-21

1

P61571
MNPSEMQRKAPPRRR

ERVK-6

1

Q69383
MNPSEMQRKAPPRRR

ERVK-9

1

P61573
RPRAQMPHLRKMERV

RGS11

11

O94810
PPARRAKRMRAEAMN

KDM5B

226

Q9UGL1
MPARALLPRRMGHRT

OGG1

1

O15527
QPRASEMQHLRRMPR

PNOC

86

Q13519
MNPSEMQRKAPPRRR

ERVK-25

1

P61570
MNPSEMQRKAPPRRR

ERVK-6

1

Q69384
RMMHARFRNPLSRQP

FNDC1

1301

Q4ZHG4
SPEPSMSPKMHRRRS

CCP110

366

O43303
MHPSEMQRKAPPRRR

ERVK-21

1

P61565
MNPSEMQRKAPPRRR

HERVK_113

1

Q902F9
PAMRMHLLGQLRKPR

OAS3

681

Q9Y6K5
TPRKPRSHRSMGVRM

TSGA10IP

511

Q3SY00
MPPERRRRMKLDRRT

UTP18

1

Q9Y5J1
AHMRMILRKPPGQRT

RAPGEF4

326

Q8WZA2
PPNPIRSLMSMIRKR

SHTN1

366

A0MZ66
MMTVSPPPAHRHRRR

SPEM1

101

Q8N4L4
RPNRPLAKMAEMARR

TRIM11

66

Q96F44
KMRQRPPPRRDMTIP

SH3PXD2B

341

A1X283
PDWRRLPREMMPRNK

POLR3G

101

O15318
MNPSEMQRKAPPRRR

ERVK-8

1

P61575
RRPVAMVMPARRTPH

PLEC

101

Q15149