Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	RAF1 FCSK CRLS1 MTOR ADCK5 POLR3H SELENOO DYRK1A POLR1B LRRK1 TRRAP MTPAP PIGO MAP3K1	7.48e-05	938	90	14	GO:0016772
GeneOntologyBiologicalProcess	calcineurin-NFAT signaling cascade	NRG1 PPP3CA MTOR DYRK1A CAMTA1	3.57e-06	54	89	5	GO:0033173
GeneOntologyBiologicalProcess	calcineurin-mediated signaling	NRG1 PPP3CA MTOR DYRK1A CAMTA1	5.11e-06	58	89	5	GO:0097720
GeneOntologyBiologicalProcess	negative regulation of cellular component organization	RAF1 SETMAR PPP3CA MTOR KHDC3L DIAPH1 DYRK1A BCL11A DENND5A ITGA3 DDX3X MAP3K1 SMG6 RAD50	1.89e-05	864	89	14	GO:0051129
GeneOntologyBiologicalProcess	regulation of calcineurin-NFAT signaling cascade	NRG1 PPP3CA MTOR CAMTA1	3.85e-05	44	89	4	GO:0070884
GeneOntologyBiologicalProcess	T cell differentiation	NCOR1 LIG4 BCL11B MTOR SMARCD2 BCL11A BCL6 STAT4 SOS2	4.02e-05	382	89	9	GO:0030217
GeneOntologyBiologicalProcess	regulation of calcineurin-mediated signaling	NRG1 PPP3CA MTOR CAMTA1	4.22e-05	45	89	4	GO:0106056
GeneOntologyBiologicalProcess	regulation of protein autophosphorylation	NRG1 MVP DDX3X RAD50	4.60e-05	46	89	4	GO:0031952
GeneOntologyBiologicalProcess	positive regulation of calcineurin-mediated signaling	NRG1 PPP3CA CAMTA1	9.76e-05	21	89	3	GO:0106058
GeneOntologyBiologicalProcess	positive regulation of calcineurin-NFAT signaling cascade	NRG1 PPP3CA CAMTA1	9.76e-05	21	89	3	GO:0070886
GeneOntologyBiologicalProcess	response to nitrogen compound	HDAC9 RAF1 FCSK PPP2R2A CRLS1 CIB2 PPP3CA MTOR DIAPH1 BCL11A CHRNA3 FAF1 STAT4 HTT ITPR2 SOS2	9.79e-05	1272	89	16	GO:1901698
GeneOntologyBiologicalProcess	lymphocyte differentiation	HDAC9 NCOR1 LIG4 BCL11B MTOR SMARCD2 BCL11A BCL6 STAT4 SOS2	1.06e-04	537	89	10	GO:0030098
GeneOntologyBiologicalProcess	leukocyte differentiation	HDAC9 NCOR1 LIG4 BCL11B PPP3CA MTOR SMARCD2 BCL11A LRRK1 BCL6 STAT4 SOS2	1.44e-04	789	89	12	GO:0002521
GeneOntologyBiologicalProcess	calcium-mediated signaling	NRG1 PPP3CA MTOR DYRK1A CAMTA1 HTT ITPR2	1.53e-04	266	89	7	GO:0019722
GeneOntologyBiologicalProcess	regulation of kinase activity	CASS4 NRG1 MTOR NLRC5 PLEC MVP CHRNA3 DDX3X MAP3K1 HTT RAD50	1.76e-04	686	89	11	GO:0043549
GeneOntologyBiologicalProcess	regulation of calcium-mediated signaling	NRG1 PPP3CA MTOR CAMTA1 HTT	1.79e-04	121	89	5	GO:0050848
GeneOntologyBiologicalProcess	somatic recombination of T cell receptor gene segments	LIG4 BCL11B	1.83e-04	5	89	2	GO:0002681
GeneOntologyBiologicalProcess	T cell receptor V(D)J recombination	LIG4 BCL11B	1.83e-04	5	89	2	GO:0033153
GeneOntologyBiologicalProcess	somatic diversification of T cell receptor genes	LIG4 BCL11B	1.83e-04	5	89	2	GO:0002568
GeneOntologyBiologicalProcess	regulation of transferase activity	CASS4 NRG1 MTOR NLRC5 PLEC MVP CHRNA3 DDX3X MAP3K1 HTT SMG6 RAD50	1.83e-04	810	89	12	GO:0051338
GeneOntologyBiologicalProcess	DNA metabolic process	HSPD1 HDAC9 LIG4 SETMAR BCL11B GTF2H4 KHDC3L SMARCD2 BCL6 TRRAP FAF1 XAB2 SMG6 RAD50	2.09e-04	1081	89	14	GO:0006259
GeneOntologyBiologicalProcess	T cell activation	HSPD1 NCOR1 LIG4 BCL11B PPP3CA MTOR SMARCD2 BCL11A BCL6 STAT4 SOS2	2.12e-04	701	89	11	GO:0042110
GeneOntologyBiologicalProcess	locomotory behavior	B4GALT2 NCOR1 NRG1 MTOR CHRNA3 HTT RNF170	2.29e-04	284	89	7	GO:0007626
GeneOntologyBiologicalProcess	positive regulation of protein autophosphorylation	NRG1 DDX3X RAD50	2.62e-04	29	89	3	GO:0031954
GeneOntologyBiologicalProcess	regulation of phosphate metabolic process	CASS4 RAF1 NCOR1 NRG1 MTOR NLRC5 LRRK1 PLEC CAMTA1 MVP CHRNA3 DDX3X MAP3K1 HTT SMG6 RAD50	3.47e-04	1421	89	16	GO:0019220
GeneOntologyBiologicalProcess	regulation of phosphorus metabolic process	CASS4 RAF1 NCOR1 NRG1 MTOR NLRC5 LRRK1 PLEC CAMTA1 MVP CHRNA3 DDX3X MAP3K1 HTT SMG6 RAD50	3.52e-04	1423	89	16	GO:0051174
GeneOntologyBiologicalProcess	activation of transmembrane receptor protein tyrosine kinase activity	NRG1 CHRNA3	3.81e-04	7	89	2	GO:0007171
GeneOntologyBiologicalProcess	cellular response to nitrogen compound	HDAC9 RAF1 CIB2 PPP3CA MTOR DIAPH1 BCL11A CHRNA3 HTT ITPR2 SOS2	3.86e-04	752	89	11	GO:1901699
GeneOntologyBiologicalProcess	mononuclear cell differentiation	HDAC9 NCOR1 LIG4 BCL11B MTOR SMARCD2 BCL11A BCL6 STAT4 SOS2	4.33e-04	640	89	10	GO:1903131
GeneOntologyBiologicalProcess	somatic cell DNA recombination	HSPD1 LIG4 BCL11B BCL6	4.38e-04	82	89	4	GO:0016444
GeneOntologyBiologicalProcess	regulation of carbohydrate catabolic process	PPP1R3C NCOR1 MTOR PPP1CB	4.38e-04	82	89	4	GO:0043470
GeneOntologyBiologicalProcess	somatic diversification of immune receptors via germline recombination within a single locus	HSPD1 LIG4 BCL11B BCL6	4.38e-04	82	89	4	GO:0002562
GeneOntologyBiologicalProcess	protein autophosphorylation	NRG1 MTOR DYRK1A MVP DDX3X RAD50	4.62e-04	228	89	6	GO:0046777
GeneOntologyBiologicalProcess	renal filtration	PPP3CA SULF1 ITGA3	5.00e-04	36	89	3	GO:0097205
GeneOntologyBiologicalProcess	peptidyl-tyrosine modification	CASS4 TPST2 NRG1 MTOR DYRK1A LRRK1 MVP	5.55e-04	329	89	7	GO:0018212
GeneOntologyBiologicalProcess	nucleotide-excision repair	LIG4 GTF2H4 SMARCD2 XAB2	5.73e-04	88	89	4	GO:0006289
GeneOntologyBiologicalProcess	regulation of glycogen biosynthetic process	PPP1R3C MTOR PPP1CB	5.87e-04	38	89	3	GO:0005979
GeneOntologyBiologicalProcess	regulation of glucan biosynthetic process	PPP1R3C MTOR PPP1CB	5.87e-04	38	89	3	GO:0010962
GeneOntologyBiologicalProcess	alpha-beta T cell differentiation	NCOR1 BCL11B MTOR BCL6 STAT4	5.95e-04	157	89	5	GO:0046632
GeneOntologyBiologicalProcess	negative regulation of telomere capping	SMG6 RAD50	6.50e-04	9	89	2	GO:1904354
GeneOntologyBiologicalProcess	somatic diversification of immune receptors	HSPD1 LIG4 BCL11B BCL6	6.50e-04	91	89	4	GO:0002200
GeneOntologyBiologicalProcess	dephosphorylation	PPP2R2A PPP3CA MTOR CAMTA1 HTT PPP1CB SMG6	7.59e-04	347	89	7	GO:0016311
GeneOntologyBiologicalProcess	positive regulation of double-strand break repair	SETMAR KHDC3L SMARCD2 TRRAP	7.64e-04	95	89	4	GO:2000781
GeneOntologyCellularComponent	phosphatase complex	PPP1R3C PPP2R2A PPP3CA PPP1CB	9.26e-05	55	90	4	GO:1903293
GeneOntologyCellularComponent	protein serine/threonine phosphatase complex	PPP1R3C PPP2R2A PPP3CA PPP1CB	9.26e-05	55	90	4	GO:0008287
GeneOntologyCellularComponent	nuclear protein-containing complex	IVNS1ABP HDAC9 NCOR1 LIG4 BCL11B GTF2H4 POLR3H SMARCD2 POLR1B BCL11A TRRAP MVP XAB2 STAT4 SMG6 RAD50	2.39e-04	1377	90	16	GO:0140513
GeneOntologyCellularComponent	SWI/SNF complex	BCL11B SMARCD2 BCL11A	2.88e-04	30	90	3	GO:0016514
GeneOntologyCellularComponent	glycogen granule	PPP1R3C PPP1CB	5.05e-04	8	90	2	GO:0042587
GeneOntologyCellularComponent	SWI/SNF superfamily-type complex	BCL11B SMARCD2 BCL11A TRRAP	7.89e-04	96	90	4	GO:0070603
GeneOntologyCellularComponent	paraspeckles	BCL11A BCL6	8.07e-04	10	90	2	GO:0042382
HumanPheno	Thickened helices	RAF1 DYRK1A PIGO DDX3X PPP1CB SOS2	4.61e-06	47	49	6	HP:0000391
HumanPheno	Curly hair	RAF1 MTOR ST14 PPP1CB SOS2	2.01e-05	36	49	5	HP:0002212
Domain	FAT	MTOR TRRAP	3.33e-04	6	89	2	PS51189
Domain	FATC	MTOR TRRAP	3.33e-04	6	89	2	PS51190
Domain	FAT	MTOR TRRAP	3.33e-04	6	89	2	PF02259
Domain	PIK-rel_kinase_FAT	MTOR TRRAP	3.33e-04	6	89	2	IPR003151
Domain	FATC_dom	MTOR TRRAP	3.33e-04	6	89	2	IPR003152
Domain	PIK_FAT	MTOR TRRAP	3.33e-04	6	89	2	IPR014009
Domain	FATC	MTOR TRRAP	3.33e-04	6	89	2	SM01343
Domain	PP2Ac	PPP3CA PPP1CB	1.69e-03	13	89	2	SM00156
Domain	Ser/Thr-sp_prot-phosphatase	PPP3CA PPP1CB	1.69e-03	13	89	2	IPR006186
Domain	SER_THR_PHOSPHATASE	PPP3CA PPP1CB	1.69e-03	13	89	2	PS00125
Domain	FH2	GRID2IP DIAPH1	2.26e-03	15	89	2	PS51444
Domain	FH2_Formin	GRID2IP DIAPH1	2.26e-03	15	89	2	IPR015425
Domain	FH2	GRID2IP DIAPH1	2.26e-03	15	89	2	PF02181
Domain	FH2	GRID2IP DIAPH1	2.26e-03	15	89	2	SM00498
Domain	-	MTOR TRRAP	2.58e-03	16	89	2	1.10.1070.11
Domain	PI3Kc	MTOR TRRAP	2.58e-03	16	89	2	SM00146
Domain	-	MTOR CFAP70 TRRAP XAB2 SMG6	3.11e-03	207	89	5	1.25.40.10
Domain	PI3_PI4_kinase	MTOR TRRAP	3.27e-03	18	89	2	PF00454
Domain	PI3_4_KINASE_1	MTOR TRRAP	3.27e-03	18	89	2	PS00915
Domain	PI3_4_KINASE_2	MTOR TRRAP	3.27e-03	18	89	2	PS00916
Domain	PI3/4_kinase_cat_dom	MTOR TRRAP	3.27e-03	18	89	2	IPR000403
Domain	PI3_4_KINASE_3	MTOR TRRAP	3.27e-03	18	89	2	PS50290
Domain	TPR-like_helical_dom	MTOR CFAP70 TRRAP XAB2 SMG6	5.14e-03	233	89	5	IPR011990
Domain	Pentatricopeptide_repeat	XAB2 HTT	5.32e-03	23	89	2	IPR002885
Domain	ARM-type_fold	MTOR DIAPH1 TRRAP MAP3K1 HTT ITPR2	5.63e-03	339	89	6	IPR016024
Pathway	WP_CARDIAC_HYPERTROPHIC_RESPONSE	HDAC9 RAF1 NRG1 PPP3CA MTOR MAP3K1	2.02e-07	55	66	6	M39685
Pathway	SIG_BCR_SIGNALING_PATHWAY	RAF1 PPP3CA ITPR2 SOS2	6.17e-05	46	66	4	M8626
Pathway	WP_RETT_SYNDROME	NCOR1 TRRAP XAB2 HTT	7.30e-05	48	66	4	M39759
Pathway	BIOCARTA_MAL_PATHWAY	RAF1 DIAPH1 MAP3K1	7.61e-05	18	66	3	MM1482
Pathway	BIOCARTA_MAL_PATHWAY	RAF1 DIAPH1 MAP3K1	9.00e-05	19	66	3	M10547
Pathway	WP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY	HDAC9 RAF1 NRG1 PPP3CA MTOR	9.82e-05	99	66	5	MM15905
Pathway	WP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY	HDAC9 RAF1 NRG1 PPP3CA MTOR	1.24e-04	104	66	5	M39625
Pathway	KEGG_LONG_TERM_POTENTIATION	RAF1 PPP3CA PPP1CB ITPR2	3.19e-04	70	66	4	M3115
Pathway	KEGG_FOCAL_ADHESION	COL4A4 RAF1 DIAPH1 ITGA3 PPP1CB SOS2	3.30e-04	199	66	6	M7253
Pathway	REACTOME_LAMININ_INTERACTIONS	COL4A4 COL7A1 ITGA3	3.64e-04	30	66	3	M27216
Pathway	WP_JOUBERT_SYNDROME	PDE6B MTOR CC2D2A RAD50	4.37e-04	76	66	4	M39835
Pathway	BIOCARTA_BCR_PATHWAY	RAF1 PPP3CA MAP3K1	4.41e-04	32	66	3	MM1355
Pathway	KEGG_INSULIN_SIGNALING_PATHWAY	PPP1R3C RAF1 MTOR PPP1CB SOS2	4.48e-04	137	66	5	M18155
Pathway	WP_MAPK_CASCADE	RAF1 MAP3K1 SOS2	4.84e-04	33	66	3	M39594
Pathway	BIOCARTA_BCR_PATHWAY	RAF1 PPP3CA MAP3K1	4.84e-04	33	66	3	M9494
Pathway	BIOCARTA_FMLP_PATHWAY	RAF1 PPP3CA MAP3K1	5.29e-04	34	66	3	M10287
Pathway	BIOCARTA_FMLP_PATHWAY	RAF1 PPP3CA MAP3K1	5.29e-04	34	66	3	MM1399
Pathway	REACTOME_SIGNALING_BY_MRAS_COMPLEX_MUTANTS	RAF1 PPP1CB	5.94e-04	8	66	2	M38999
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_MRAS_SHOC2_PP1_HOLOPHOSPHATASE	RAF1 PPP1CB	5.94e-04	8	66	2	M47933
Pathway	WP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE	RAF1 NRG1 MTOR SOS2	6.38e-04	84	66	4	M39839
Pathway	WP_HEPATITIS_B_INFECTION	RAF1 DDX3X MAP3K1 STAT4 SOS2	6.97e-04	151	66	5	M39801
Pathway	KEGG_ERBB_SIGNALING_PATHWAY	RAF1 NRG1 MTOR SOS2	7.29e-04	87	66	4	M12467
Pathway	BIOCARTA_FCER1_PATHWAY	RAF1 PPP3CA MAP3K1	7.94e-04	39	66	3	MM1397
Pathway	BIOCARTA_FCER1_PATHWAY	RAF1 PPP3CA MAP3K1	7.94e-04	39	66	3	M1908
Pathway	WP_ERBB_SIGNALING	RAF1 NRG1 MTOR SOS2	8.99e-04	92	66	4	M39715
Pathway	BIOCARTA_TCR_PATHWAY	RAF1 PPP3CA MAP3K1	9.88e-04	42	66	3	MM1504
Pathway	WP_EUKARYOTIC_TRANSCRIPTION_INITIATION	GTF2H4 POLR3H POLR1B	9.88e-04	42	66	3	M39386
Pathway	WP_EUKARYOTIC_TRANSCRIPTION_INITIATION	GTF2H4 POLR3H POLR1B	1.06e-03	43	66	3	MM15919
Pathway	BIOCARTA_TCR_PATHWAY	RAF1 PPP3CA MAP3K1	1.13e-03	44	66	3	M19784
Pathway	PID_ERBB2_ERBB3_PATHWAY	RAF1 NRG1 MTOR	1.13e-03	44	66	3	M175
Pathway	REACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION	PPP3CA ITPR2	1.16e-03	11	66	2	M27466
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH3 DCTN4 HTT	1.21e-03	45	66	3	M47670
Pathway	KEGG_GNRH_SIGNALING_PATHWAY	RAF1 MAP3K1 ITPR2 SOS2	1.27e-03	101	66	4	M1979
Pathway	WP_MAPK_AND_NFKB_SIGNALING_INHIBITED_BY_YERSINIA_YOPJ	RAF1 MAP3K1	1.38e-03	12	66	2	M39552
Pathway	PID_ERBB1_DOWNSTREAM_PATHWAY	RAF1 PPP2R2A MTOR MAP3K1	1.47e-03	105	66	4	M164
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY	MAP3K1 SOS2	1.63e-03	13	66	2	M47594
Pathway	KEGG_NON_HOMOLOGOUS_END_JOINING	LIG4 RAD50	1.63e-03	13	66	2	M7857
Pathway	REACTOME_ERBB2_REGULATES_CELL_MOTILITY	NRG1 DIAPH1	1.63e-03	13	66	2	MM15320
Pathway	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	RAF1 LNPEP SOS2	1.74e-03	51	66	3	M7955
Pathway	WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER	RAF1 MTOR SMARCD2 RAD50	1.74e-03	110	66	4	M48043
Pathway	WP_EGFR1_SIGNALING_PATHWAY	RAF1 PLEC MAP3K1 HTT SOS2	1.85e-03	188	66	5	MM15828
Pathway	KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	1.89e-03	14	66	2	M47364
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	1.89e-03	14	66	2	M47365
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	1.89e-03	14	66	2	M47366
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	1.89e-03	14	66	2	M47378
Pathway	KEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	1.89e-03	14	66	2	M47488
Pathway	WP_INTERFERON_TYPE_I_SIGNALING	MTOR MAP3K1 STAT4	2.05e-03	54	66	3	M39435
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.18e-03	15	66	2	M47367
Pathway	KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE	B4GALT2 B4GAT1	2.18e-03	15	66	2	M3042
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.18e-03	15	66	2	M47375
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.18e-03	15	66	2	M47380
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.18e-03	15	66	2	M47592
Pathway	KEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.18e-03	15	66	2	M47593
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.18e-03	15	66	2	M47640
Pathway	REACTOME_ANCHORING_FIBRIL_FORMATION	COL4A4 COL7A1	2.18e-03	15	66	2	M27161
Pathway	REACTOME_ERBB2_REGULATES_CELL_MOTILITY	NRG1 DIAPH1	2.18e-03	15	66	2	M27608
Pathway	REACTOME_LAMININ_INTERACTIONS	COL4A4 ITGA3	2.18e-03	15	66	2	MM14922
Pathway	KEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.18e-03	15	66	2	M47485
Pathway	KEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.18e-03	15	66	2	M47473
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.18e-03	15	66	2	M47474
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY	MTOR SOS2	2.18e-03	15	66	2	M47475
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.18e-03	15	66	2	M47480
Pathway	KEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.18e-03	15	66	2	M47495
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.18e-03	15	66	2	M47496
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.18e-03	15	66	2	M47497
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.18e-03	15	66	2	M47472
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.18e-03	15	66	2	M47535
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.18e-03	15	66	2	M47531
Pathway	WP_11P112_COPY_NUMBER_VARIATION_SYNDROME	B4GAT1 ITGA3 LGALS3BP	2.28e-03	56	66	3	M48075
Pathway	WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS	RAF1 ABCG4 MTOR HTT	2.32e-03	119	66	4	M48309
Pathway	WP_FOCAL_ADHESION	COL4A4 RAF1 DIAPH1 ITGA3 PPP1CB	2.37e-03	199	66	5	M39402
Pathway	KEGG_ACUTE_MYELOID_LEUKEMIA	RAF1 MTOR SOS2	2.39e-03	57	66	3	M19888
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.48e-03	16	66	2	M47363
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.48e-03	16	66	2	M47373
Pathway	KEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.48e-03	16	66	2	M47381
Pathway	KEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.48e-03	16	66	2	M47804
Pathway	WP_MAPK_PATHWAY_IN_CONGENITAL_THYROID_CANCER	RAF1 SOS2	2.48e-03	16	66	2	M39882
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY	RAF1 SOS2	2.48e-03	16	66	2	M47483
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TPST2 NCOR1 MTOR MRPL55 DYRK1A NLRC5 SPATA20 LRRK1 DENND5A ITGA3 PLEC TRRAP ST14 ABTB2 HTT SMG6 ITPR2	4.54e-09	1105	92	17	35748872
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	HSPD1 PPP2R2A GTF2H4 BYSL ZNF638 MRPS34 SMARCD2 POLR1B PLEC MVP MTPAP XAB2 DDX3X LGALS3BP PPP1CB ITPR2 RAD50 MICU1	4.58e-09	1257	92	18	36526897
Pubmed	Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6-dependent pathway.	BCL11B BCL11A BCL6	7.15e-08	4	92	3	35766181
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	HSPD1 IVNS1ABP NCOR1 POGLUT1 PPP3CA LNPEP DIAPH1 MRPS34 ITGA3 TRRAP MTPAP PIGO XAB2 DDX3X LGALS3BP PPP1CB	2.79e-07	1297	92	16	33545068
Pubmed	mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability.	PPP2R2A MTOR POLR1B	6.22e-07	7	92	3	15004009
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PPP2R2A POGLUT1 PPP3CA STXBP5L ZNF638 NLRC5 DENND5A CAMTA1 TRRAP NAALADL2 FAF1 HTT PPP1CB SMG6 SOS2 MICU1	1.71e-06	1489	92	16	28611215
Pubmed	Ski regulates Hippo and TAZ signaling to suppress breast cancer progression.	HSPD1 NCOR1 DIAPH1 PLEC MVP	3.04e-06	84	92	5	25670202
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	RAF1 FCSK PPP2R2A SETMAR MTOR DYRK1A MRPS34 POLR1B MTPAP PPP1CB	4.80e-06	606	92	10	36538041
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	HSPD1 IVNS1ABP PPP2R2A PPP3CA MTOR LNPEP DIAPH1 BYSL PLEC DCTN4 MVP FAF1 DDX3X HTT PPP1CB	6.20e-06	1455	92	15	22863883
Pubmed	The histone deacetylase 9 gene encodes multiple protein isoforms.	HDAC9 NCOR1 BCL6	6.38e-06	14	92	3	12590135
Pubmed	COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein.	BCL11B BCL11A	6.92e-06	2	92	2	12196208
Pubmed	CTIP1 and CTIP2 are differentially expressed during mouse embryogenesis.	BCL11B BCL11A	6.92e-06	2	92	2	15465497
Pubmed	Correlation of gene expression of ATP-binding cassette protein and tyrosine kinase signaling pathway in patients with hepatocellular carcinoma.	RAF1 MAP3K1	6.92e-06	2	92	2	22110214
Pubmed	Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells.	BCL11A BCL6	6.92e-06	2	92	2	16704730
Pubmed	The BCL11 gene family: involvement of BCL11A in lymphoid malignancies.	BCL11B BCL11A	6.92e-06	2	92	2	11719382
Pubmed	Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease.	BCL11B HTT	6.92e-06	2	92	2	18595722
Pubmed	The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations.	LIG4 SETMAR	6.92e-06	2	92	2	20620605
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NCOR1 BCL11B PPP3CA MTOR DIAPH1 DYRK1A SPATA20 BCL11A DDX3X PPP1CB SMG6 RAD50	9.01e-06	963	92	12	28671696
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	COL4A4 TPST2 COL7A1 PPP2R2A POGLUT1 B4GAT1 LNPEP ITGA3 PIGO LGALS3BP HTT ITPR2 RNF170	1.66e-05	1201	92	13	35696571
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	MTOR MRPS34 SMARCD2 POLR1B DCTN4 TRRAP MTPAP DDX3X PPP1CB RAD50	1.76e-05	704	92	10	29955894
Pubmed	Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively.	RAF1 DDX3X	2.07e-05	3	92	2	9693046
Pubmed	Identification of heat shock protein 60 as a molecular mediator of alpha 3 beta 1 integrin activation.	HSPD1 ITGA3	2.07e-05	3	92	2	11888933
Pubmed	Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function.	NCOR1 MAP3K1	2.07e-05	3	92	2	11971970
Pubmed	ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of phosphatidylinositol 3-kinase and Ras/MAPK pathway.	RAF1 NRG1	2.07e-05	3	92	2	8707830
Pubmed	Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation.	NCOR1 HTT	2.07e-05	3	92	2	12799135
Pubmed	The PP242 mammalian target of rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of rapamycin complex 1 (TORC1)/eukaryotic translation initiation factor 4E (eIF-4E)/RAF pathway and activation is a mechanism of resistance.	RAF1 MTOR	2.07e-05	3	92	2	22556409
Pubmed	Association of Target Therapy Gene Expression with Metastasizing of Clear-Cell Renal Cell Carcinoma.	RAF1 MTOR	2.07e-05	3	92	2	30488209
Pubmed	Rod and cone degeneration in the rd mouse is p53 independent.	PDE6B HTT	2.07e-05	3	92	2	11344337
Pubmed	Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.	PPP3CA ITPR2	2.07e-05	3	92	2	21435446
Pubmed	mTORC1/C2 and pan-HDAC inhibitors synergistically impair breast cancer growth by convergent AKT and polysome inhibiting mechanisms.	HDAC9 MTOR	2.07e-05	3	92	2	24562770
Pubmed	Regulation of pulmonary fibrosis by chemokine receptor CXCR3.	BCL11B BCL11A	2.07e-05	3	92	2	15254596
Pubmed	BYSL contributes to tumor growth by cooperating with the mTORC2 complex in gliomas.	MTOR BYSL	2.07e-05	3	92	2	33628587
Pubmed	Analysis of BCL6-interacting proteins by tandem mass spectrometry.	HDAC9 NCOR1 BCL11A BCL6	2.27e-05	62	92	4	16147992
Pubmed	Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers.	BCL11B STAB2 BCL11A	2.66e-05	22	92	3	27117402
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	RAF1 PPP2R2A GTF2H4 DYRK1A PLEC DCTN4 TRRAP MAP3K1 PPP1CB ITPR2 RAD50	2.89e-05	910	92	11	36736316
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	HSPD1 NCOR1 ZNF638 PLEC XAB2 DDX3X RAD50	2.97e-05	332	92	7	32786267
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	HDAC9 SETMAR PPP3CA B4GAT1 SULF1 DYRK1A PLEC MVP FAF1 XAB2 DDX3X SOS2 MICU1	3.34e-05	1285	92	13	35914814
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	HSPD1 IVNS1ABP POGLUT1 B4GAT1 LNPEP ITGA3 DDX3X LGALS3BP RAD50	3.67e-05	613	92	9	22268729
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	RAF1 FCSK PPP2R2A BCL11B DIAPH1 SMARCD2 BCL11A ITGA3 TRRAP MTPAP LGALS3BP RAD50	3.84e-05	1116	92	12	31753913
Pubmed	Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin.	NCOR1 HTT	4.14e-05	4	92	2	10441327
Pubmed	Reprogramming towards anabolism impedes degeneration in a preclinical model of retinitis pigmentosa.	PDE6B MTOR	4.14e-05	4	92	2	27516389
Pubmed	Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease.	MTOR HTT	4.14e-05	4	92	2	25351248
Pubmed	Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction.	LIG4 RAD50	4.14e-05	4	92	2	11809878
Pubmed	Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes.	RAF1 PPP1CB	4.14e-05	4	92	2	30368668
Pubmed	mTOR kinase inhibition disrupts neuregulin 1-ERBB3 autocrine signaling and sensitizes NF2-deficient meningioma cellular models to IGF1R inhibition.	NRG1 MTOR	4.14e-05	4	92	2	33273014
Pubmed	Ribosomal protein S6 kinase 1 promotes the survival of photoreceptors in retinitis pigmentosa.	PDE6B MTOR	4.14e-05	4	92	2	30442943
Pubmed	Systematic identification of cellular signals reactivating Kaposi sarcoma-associated herpesvirus.	RAF1 MAP3K1	4.14e-05	4	92	2	17397260
Pubmed	DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding.	RAF1 DYRK1A	4.14e-05	4	92	2	17229891
Pubmed	Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR).	MTOR STAT4	4.14e-05	4	92	2	15522880
Pubmed	Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesis.	PPP1R3C PPP1CB	4.14e-05	4	92	2	21471512
Pubmed	Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation.	LIG4 RAD50	4.14e-05	4	92	2	18854157
Pubmed	Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa.	PDE6B MTOR	4.14e-05	4	92	2	19060896
Pubmed	Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program.	BCL6 STAT4	4.14e-05	4	92	2	24489092
Pubmed	Des-gamma-carboxy prothrombin antagonizes the effects of Sorafenib on human hepatocellular carcinoma through activation of the Raf/MEK/ERK and PI3K/Akt/mTOR signaling pathways.	RAF1 MTOR	4.14e-05	4	92	2	27167344
Pubmed	A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf.	RAF1 MAP3K1	4.14e-05	4	92	2	8385802
Pubmed	Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein.	PPP2R2A MTOR	4.14e-05	4	92	2	10200280
Pubmed	Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable.	HTT ITPR2	4.14e-05	4	92	2	33086039
Pubmed	Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors.	BCL11B BCL11A	4.14e-05	4	92	2	10744719
Pubmed	N-CoR controls differentiation of neural stem cells into astrocytes.	NCOR1 PPP1CB	4.14e-05	4	92	2	12410313
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	RAF1 LIG4 BYSL ZNF638 TRRAP LGALS3BP RAD50	5.31e-05	364	92	7	24778252
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	HSPD1 DNAH3 PPP3CA ITGA3 PLEC MVP DDX3X LGALS3BP PPP1CB SOS2	5.33e-05	803	92	10	36517590
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	HSPD1 RAF1 PLEC LGALS3BP HTT	5.40e-05	152	92	5	34299191
Pubmed	Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.	RAF1 ABCG4 NCOR1 PPP3CA MTOR BCL6	5.53e-05	250	92	6	18660489
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	HSPD1 GTF2H4 DIAPH1 BYSL ZNF638 POLR1B PLEC DCTN4 TRRAP MVP MTPAP PPP1CB RAD50	5.67e-05	1353	92	13	29467282
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MTOR BYSL ZNF638 PLEC TRRAP MVP XAB2 PPP1CB RAD50	5.97e-05	653	92	9	22586326
Pubmed	The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.	HSPD1 LRRK1 PLEC SOS2	6.53e-05	81	92	4	20697350
Pubmed	Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.	HSPD1 NCOR1 PPP2R2A DDX3X LGALS3BP RAD50	6.58e-05	258	92	6	21081666
Pubmed	Myelodysplastic syndrome: an inability to appropriately respond to damaged DNA?	LIG4 RAD50	6.89e-05	5	92	2	23643835
Pubmed	Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.	NCOR1 BCL6	6.89e-05	5	92	2	15531890
Pubmed	The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions.	DYRK1A MAP3K1	6.89e-05	5	92	2	20940704
Pubmed	Dyrk1a Mutations Cause Undergrowth of Cortical Pyramidal Neurons via Dysregulated Growth Factor Signaling.	MTOR DYRK1A	6.89e-05	5	92	2	33840455
Pubmed	p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association.	RAF1 BCL6	6.89e-05	5	92	2	15849194
Pubmed	Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.	RAF1 MTOR	6.89e-05	5	92	2	15150271
Pubmed	Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.	NCOR1 BCL6	6.89e-05	5	92	2	11865059
Pubmed	Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.	HSPD1 RAF1	6.89e-05	5	92	2	15618521
Pubmed	Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation.	RAF1 MTOR	6.89e-05	5	92	2	19703998
Pubmed	Morphoproteomic profile of mTOR, Ras/Raf kinase/ERK, and NF-kappaB pathways in human gastric adenocarcinoma.	RAF1 MTOR	6.89e-05	5	92	2	18715846
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	NCOR1 ZNF638 MRPS34 POLR1B DCTN4 TRRAP MVP XAB2 DDX3X PPP1CB	8.29e-05	847	92	10	35850772
Pubmed	RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair.	DYRK1A RAD50	1.03e-04	6	92	2	30104380
Pubmed	Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease.	MTOR ITGA3	1.03e-04	6	92	2	20852388
Pubmed	Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex.	TRRAP RAD50	1.03e-04	6	92	2	20070254
Pubmed	Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway.	RAF1 MTOR	1.03e-04	6	92	2	19222999
Pubmed	Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.	BCL11B BCL11A	1.03e-04	6	92	2	23644491
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	HSPD1 IVNS1ABP PPP2R2A BYSL PLEC XAB2 DDX3X RAD50	1.09e-04	551	92	8	34728620
Pubmed	The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking.	MRPS34 CC2D2A DCTN4 MTPAP HTT	1.11e-04	177	92	5	26485645
Pubmed	Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly.	ITGA3 MVP DDX3X PPP1CB	1.12e-04	93	92	4	38245532
Pubmed	The functional interactome landscape of the human histone deacetylase family.	HDAC9 NCOR1 PPP2R2A BCL11B BCL11A XAB2	1.22e-04	289	92	6	23752268
Pubmed	A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins.	HSPD1 DDX3X LGALS3BP	1.41e-04	38	92	3	18247557
Pubmed	MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.	NCOR1 BCL6	1.44e-04	7	92	2	15454082
Pubmed	HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling.	HDAC9 NCOR1	1.44e-04	7	92	2	11486045
Pubmed	alpha3beta1 Integrin is required for normal development of the epidermal basement membrane.	COL7A1 ITGA3	1.44e-04	7	92	2	9151677
Pubmed	Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation.	RAF1 MAP3K1	1.44e-04	7	92	2	21336309
Pubmed	Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.	PPP3CA ITPR2	1.44e-04	7	92	2	22495310
Pubmed	A novel tumor-promoting function residing in the 5' non-coding region of vascular endothelial growth factor mRNA.	NRG1 BCL6	1.44e-04	7	92	2	18494554
Pubmed	Strict in vivo specificity of the Bcl11a erythroid enhancer.	BCL11B BCL11A	1.44e-04	7	92	2	27707736
Pubmed	GPR56 functions together with α3β1 integrin in regulating cerebral cortical development.	BCL11B ITGA3	1.44e-04	7	92	2	23874761
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	HSPD1 NRG1 DIAPH1 ZNF638 PLEC MVP FAF1 RAD50	1.59e-04	582	92	8	20467437
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	GTF2H4 DYRK1A SMARCD2 POLR1B TRRAP DDX3X ITPR2	1.72e-04	440	92	7	34244565
Pubmed	Functional proteomics mapping of a human signaling pathway.	NCOR1 LNPEP DIAPH1 PLEC FAF1 XAB2 DDX3X PPP1CB	1.77e-04	591	92	8	15231748
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	IVNS1ABP RAF1 PPP2R2A MTOR DYRK1A ZNF638 PLEC DCTN4 MTPAP PPP1CB RAD50 MICU1	1.89e-04	1321	92	12	27173435
Interaction	CREBBP interactions	NCOR1 LIG4 PPP2R2A DYRK1A POLR1B BCL6 TRRAP FAF1 DDX3X STAT4 HTT RAD50 SOS2	1.93e-06	599	88	13	int:CREBBP
Interaction	TOP3B interactions	TPST2 NCOR1 MTOR MRPL55 BYSL DYRK1A NLRC5 SPATA20 LRRK1 DENND5A ITGA3 PLEC DCTN4 TRRAP ST14 ABTB2 DDX3X HTT SMG6 ITPR2	4.05e-06	1470	88	20	int:TOP3B
Interaction	B4GALT2 interactions	B4GALT2 HSPD1 FCSK NCOR1 DYRK1A ST14	1.36e-05	119	88	6	int:B4GALT2
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPP3CA PPP1CB	1.03e-03	13	67	2	693
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	IVNS1ABP BCL6 ABTB2 LGALS3BP	1.54e-03	134	67	4	861
GeneFamily	EF-hand domain containing\|Nucleotide excision repair\|Transcription and export complex 2	GTF2H4 XAB2	1.99e-03	18	67	2	1269
ToppCell	facs-Thymus-nan-3m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIG4 BCL11B SMARCD2 BCL6 ABTB2 DDX3X MAP3K1 PPP1CB	7.06e-09	194	92	8	f1661f9f2439fca5c1012c693b0744c4e3b90a9b
ToppCell	facs-Thymus-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIG4 BCL11B SMARCD2 BCL6 ABTB2 DDX3X MAP3K1 PPP1CB	7.06e-09	194	92	8	cda1b197efb199330ea7ab25a7cee22cae22589d
ToppCell	facs-Thymus-nan-3m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIG4 BCL11B SMARCD2 BCL6 ABTB2 DDX3X MAP3K1 PPP1CB	7.06e-09	194	92	8	66c056232ac216780acf4cc8ea325bd8ed1909c9
ToppCell	facs-Thymus-nan-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIG4 BCL11B GTF2H4 SMARCD2 BCL6 ABTB2 DDX3X ITPR2	7.35e-09	195	92	8	79114b3c78cc15c413bb58f0673e7215b784a9b6
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIG4 BCL11B GTF2H4 SMARCD2 BCL6 ABTB2 ITPR2	1.54e-07	193	92	7	a6a864644e1b80b7417ea0a27281e79068a3fd3d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CASS4 HDAC9 NLRC5 BCL11A LRRK1 BCL6	2.44e-06	186	92	6	305f1726b8b5add32f1c29c74991ff34f42e0da7
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	HSPD1 LNPEP DYRK1A DDX3X STAT4 SMG6	2.60e-06	188	92	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	facs-Skin\|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIB2 BCL11B BCL11A PLEC BCL6 CAMTA1	2.85e-06	191	92	6	ae524103331fa53fa82888dbb567fc36abcee7e0
ToppCell	facs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IVNS1ABP ITGA3 PLEC BCL6 DDX3X MAP3K1	3.51e-06	198	92	6	22559b161e67b49fe8028bfaf861e069063599f5
ToppCell	(02)_MMP9/10+-(1)_GFP\|(02)_MMP9/10+ / shred by cell type by condition	IVNS1ABP HDAC9 COL7A1 ITGA3 PLEC ABTB2	3.61e-06	199	92	6	448ba982be804007f991d469eca9d885b21ae499
ToppCell	Children_(3_yrs)-Immune-dendritic_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HDAC9 ENOX1 BCL11A LRRK1 BCL6	1.60e-05	152	92	5	0769857f25da2e6169420818e61d65e33b7277b1
ToppCell	Children_(3_yrs)-Immune-dendritic_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HDAC9 ENOX1 BCL11A LRRK1 BCL6	2.11e-05	161	92	5	cd41abb7ae659d3d314281783a0aaad562b26037
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HDAC9 NLRC5 BCL11A LRRK1 BCL6	2.98e-05	173	92	5	73f858f2c45d19b9ec8d99ac02c91551790f670c
ToppCell	COVID-19-APC-like-Dendritic_cells\|COVID-19 / group, cell type (main and fine annotations)	HDAC9 ENOX1 BCL11A LRRK1 BCL6	3.89e-05	183	92	5	703364836b42aa6ac6c68b42b700ac23c4a1afc7
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOR1 LNPEP DIAPH1 ZNF638 DDX3X	3.99e-05	184	92	5	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HDAC9 NLRC5 BCL11A LRRK1 BCL6	3.99e-05	184	92	5	4f4aeef3b821a003e857fe4a195124d44b2d7479
ToppCell	LPS_only\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BCL6 MVP ABTB2 DDX3X STAT4	4.10e-05	185	92	5	a72ccb147ca505880e2da8f6a70b9d570464a691
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	POGLUT1 NLRC5 LRRK1 MVP STAT4	4.10e-05	185	92	5	19fa853f6f746ccf232a343b3c9c7a5e55800409
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HDAC9 NRG1 ITGA3 NAALADL2 PPP1CB	4.31e-05	187	92	5	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	Control-Myeloid-DC_Mature\|Control / Disease state, Lineage and Cell class	POGLUT1 ENOX1 BCL11A LRRK1 ABTB2	4.31e-05	187	92	5	049780ca2a3e6adcd89dc2cf3095b5ad068b244a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HDAC9 NRG1 ITGA3 NAALADL2 PPP1CB	4.31e-05	187	92	5	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HDAC9 NRG1 ITGA3 NAALADL2 PPP1CB	4.31e-05	187	92	5	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	COPD-Myeloid-DC_Mature\|COPD / Disease state, Lineage and Cell class	POGLUT1 ENOX1 BCL11A LRRK1 ABTB2	4.42e-05	188	92	5	de93ccb53edb8599da9e312db0e3af604c21f673
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IVNS1ABP ENOX1 CPEB3 CFAP70 NAALADL2	4.42e-05	188	92	5	2ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HDAC9 ENOX1 NLRC5 BCL11A BCL6	4.42e-05	188	92	5	d5ce3ffe783c322b4765b790e861727e46bc34b3
ToppCell	facs-Thymus-Flowthrough-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIG4 GTF2H4 SMARCD2 BCL6 MAP3K1	4.42e-05	188	92	5	59b71462338a7efbacf46577cb07e9db3363afee
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IVNS1ABP TPST2 ENOX1 CPEB3 NAALADL2	4.65e-05	190	92	5	b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IVNS1ABP HDAC9 COL7A1 ITGA3 MAP3K1	4.77e-05	191	92	5	5a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCell	COVID-19-kidney-TAL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	IVNS1ABP COL4A4 ENOX1 ITGA3 ABTB2	4.77e-05	191	92	5	fe55475ce0666ab5122447a813dc2369e24947b8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IVNS1ABP HDAC9 COL7A1 ITGA3 MAP3K1	4.77e-05	191	92	5	55ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_10\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CIB2 POGLUT1 ENOX1 BCL11A LRRK1	5.01e-05	193	92	5	7426a30ed01e5c8376b3e0ebe0f1057cfee88340
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IVNS1ABP COL7A1 LNPEP ITGA3 MAP3K1	5.01e-05	193	92	5	263d185af6ed80e639f864e4966268e0862c61dc
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IVNS1ABP COL7A1 LNPEP ITGA3 MAP3K1	5.01e-05	193	92	5	80e058c224749b5fe0ba3e944b48317c2371cb63
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IVNS1ABP COL7A1 LNPEP ITGA3 MAP3K1	5.01e-05	193	92	5	b991fbbb4618401624f0b3045f0e81a606d3a763
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_10\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CIB2 POGLUT1 ENOX1 BCL11A LRRK1	5.01e-05	193	92	5	a2194012dfa0174c6160900625c44e0fd04c50e7
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NRG1 COL7A1 MXRA5 CIB2 SULF1	5.14e-05	194	92	5	735eee6ef25589f935fa922788ebbdbfef61249e
ToppCell	10x5'-bone_marrow-Myeloid_Dendritic\|bone_marrow / Manually curated celltypes from each tissue	HDAC9 CIB2 ENOX1 BCL11A ST14	5.14e-05	194	92	5	768271ae45ff9f6aa3cd9b0ed15fa3caaa68a7b0
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A4 COL7A1 LNPEP ITGA3 MAP3K1	5.26e-05	195	92	5	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A4 COL7A1 LNPEP ITGA3 MAP3K1	5.26e-05	195	92	5	d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IVNS1ABP SULF1 MVP DDX3X PPP1CB	5.39e-05	196	92	5	66d76249bd2770cdddff2c1fe59a016e95da2124
ToppCell	(01)_IL1RL1+-(1)_GFP\|(01)_IL1RL1+ / shred by cell type by condition	HDAC9 COL7A1 ITGA3 PLEC LGALS3BP	5.39e-05	196	92	5	b598b1112242534e139318012b257ed3cb09da83
ToppCell	COVID-19-kidney-TAL\|kidney / Disease (COVID-19 only), tissue and cell type	IVNS1ABP COL4A4 HDAC9 ENOX1 ITGA3	5.39e-05	196	92	5	04f5eb206ed3016a737609a3ebac0c1fcabb94ef
ToppCell	healthy_donor-Lymphocytic-T_cell-CD8+_Memory_T_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	TPST2 BCL11B DIAPH1 NLRC5 STAT4	5.39e-05	196	92	5	af00c31612e4fe068e5fccae05368edba46bbd20
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IVNS1ABP SULF1 MVP DDX3X PPP1CB	5.39e-05	196	92	5	9bd4c146fc7555e32adfa393b3a07846eb826d25
ToppCell	(5)_Dendritic_cell-(53)_Lymphoid_DC\|(5)_Dendritic_cell / shred on Cell_type and subtype	POGLUT1 ENOX1 UPK2 ITGA3 ABTB2	5.66e-05	198	92	5	548da5fa86f9756c503ed77bcdde55bc4d1a2726
ToppCell	PSB-critical-LOC-Epithelial-Basal\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NRG1 COL7A1 MXRA5 SULF1 BCL11A	5.79e-05	199	92	5	2add64c3e4cb6384ec381f34c3f1f77e13e3f27c
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	CPEB3 DYRK1A NAALADL2 FAF1 ITPR2	5.79e-05	199	92	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Dendritic_cell-DC_activated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	POGLUT1 ENOX1 BCL11A LRRK1 ABTB2	5.93e-05	200	92	5	a4c41509ca936e137230a6ae548c90f18a566d12
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Egln3_(Cortical_subplate_interneuron)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	COL4A4 STAB2 CNDP1	1.80e-04	53	92	3	5fa009c9f30c77de6cece40a47da46241f1de54c
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Egln3_(Cortical_subplate_interneuron)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	COL4A4 STAB2 CNDP1	1.80e-04	53	92	3	52a1f2a041e3ba2b11ed753f2f57b78e68b5cc0c
ToppCell	Adult-Immune-dendritic_cell-D231\|Adult / Lineage, Cell type, age group and donor	HDAC9 CIB2 ENOX1 BCL6	2.44e-04	147	92	4	7cc4f74dd7a86247db8dc049ed7eadeb53825a96
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A4 ENOX1 BCL6 MAP3K1	2.71e-04	151	92	4	16fc903fc71e25717b9908416f0bcd29c0a65a61
ToppCell	RV-17._Lymphocyte\|RV / Chamber and Cluster_Paper	CASS4 TDRD15 BCL11B STAT4	2.85e-04	153	92	4	e1ea621184014415870e00d511386b8cc3e0833b
ToppCell	Adult-Epithelial-basal_cell-D122\|Adult / Lineage, Cell type, age group and donor	COL7A1 PDE6B STXBP5L SULF1	2.92e-04	154	92	4	38d346402417960044ae999e61f0092b46f2b591
ToppCell	COVID-19_Moderate-multiplets\|World / disease group, cell group and cell class	BCL11B ENOX1 NLRC5 STAT4	3.07e-04	156	92	4	afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCell	NS-moderate-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH3 CC2D2A EPS8L3 CFAP70	3.14e-04	157	92	4	410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell	Children_(3_yrs)-Immune-dendritic_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HDAC9 ENOX1 BCL11A LRRK1	3.54e-04	162	92	4	86a0b9dabd150dc993bfc0f3344804de7f8e4042
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	HDAC9 PPP3CA BCL11A MAP3K1	3.62e-04	163	92	4	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	Adult-Immune-dendritic_cell\|Adult / Lineage, Cell type, age group and donor	HDAC9 ENOX1 BCL11A LRRK1	3.79e-04	165	92	4	073f52698dac1fe4edd7410865f81b30e1c7196a
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|World / disease group, cell group and cell class (v2)	B4GALT2 CIB2 ENOX1 BCL11A	3.97e-04	167	92	4	bf08f17965a4dd03f371b4ed0ab0d5e62ed61307
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HDAC9 COL7A1 MTOR ITGA3	3.97e-04	167	92	4	528493896aebe7d03d4b6ad2341b12927859e2e4
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HDAC9 COL7A1 MTOR ITGA3	3.97e-04	167	92	4	a82e85caf79395baa48380786d9df32a86dfd1ce
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	B4GALT2 CIB2 ENOX1 CC2D2A	4.06e-04	168	92	4	968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l4\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BCL11B KHDC3L STAT4 ITPR2	4.06e-04	168	92	4	19d2c763b50e7168dfa7449fc407489b055526c2
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-mature_NK_T_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BCL11B KHDC3L STAT4 ITPR2	4.06e-04	168	92	4	fa198bd53b2d640d9a8684783bf5ca23314caae2
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)\|Striatum / BrainAtlas - Mouse McCarroll V32	NRG1 DYRK1A DENND5A MAP3K1	4.15e-04	169	92	4	c3bf0cb67f200d02d5a021754e9b2a68d23ea168
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)--\|Striatum / BrainAtlas - Mouse McCarroll V32	NRG1 DYRK1A DENND5A MAP3K1	4.15e-04	169	92	4	5375eb52ebadccb7bfff997a11985f23e81014d6
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)-\|Striatum / BrainAtlas - Mouse McCarroll V32	NRG1 DYRK1A DENND5A MAP3K1	4.15e-04	169	92	4	1c132d21255f5a5174ac38db4e91927f9093418e
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PPP1R3C CASS4 NRG1 DENND5A	4.24e-04	170	92	4	7fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCell	Immune-dendritic_cell\|World / Lineage, Cell type, age group and donor	HDAC9 ENOX1 BCL11A LRRK1	4.34e-04	171	92	4	6a9e2e2d3e1d8cc475bf9765129bc4a32da3b8ea
ToppCell	facs\|World / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LNPEP PLEC DCTN4 LGALS3BP	4.34e-04	171	92	4	c9990bc041a632b2f7bbebbfe737772c423d7027
ToppCell	Children_(3_yrs)-Immune-dendritic_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HDAC9 ENOX1 BCL11A LRRK1	4.34e-04	171	92	4	6a5ac0f56bd7b4543be103100fb735ca6bc5b8bf
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	HDAC9 PPP3CA BCL11A MAP3K1	4.53e-04	173	92	4	d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_1\|356C / Donor, Lineage, Cell class and subclass (all cells)	FCSK ENOX1 MTOR POLR1B	4.53e-04	173	92	4	e3cb7c8c09f937da6b8d673e9adfec5d94a15548
ToppCell	10x5'-Lung-Myeloid_Dendritic-Cycling_Dendritic\|Lung / Manually curated celltypes from each tissue	COL4A4 SETMAR ENOX1 BCL11A	4.53e-04	173	92	4	62e0c18cfed9645e34a9d7029c94a8554f773714
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SETMAR B4GAT1 PDE6B SMG6	4.63e-04	174	92	4	a79ebb01a5849c314e02594a9c95009dbb03cb8c
ToppCell	mild_COVID-19-pDC\|mild_COVID-19 / disease group, cell group and cell class (v2)	CIB2 ENOX1 BCL11A ST14	4.73e-04	175	92	4	b87f279a7519710146c49d6acccb0adedc195965
ToppCell	metastatic_Brain-T/NK_cells-Exhausted_Tfh\|metastatic_Brain / Location, Cell class and cell subclass	NCOR1 BCL11B PCIF1 STAT4	4.73e-04	175	92	4	b732c6a423c28856211002107d8c611dcfb6f265
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	FCSK ENOX1 MTOR POLR1B	4.94e-04	177	92	4	36b5d29caa9cffbc0284f771a4db71aa72171a89
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HDAC9 DENND5A ITGA3 PLEC	5.05e-04	178	92	4	a0ab20c588e7d43d0320d4779d9ab95c1c86e297
ToppCell	facs-Lung-EPCAM-24m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POGLUT1 NLRC5 LRRK1 STAT4	5.15e-04	179	92	4	51872338e54c5f3e42ca9f1c4cf1e8b0cb84afcc
ToppCell	facs-Lung-EPCAM-24m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POGLUT1 NLRC5 LRRK1 STAT4	5.15e-04	179	92	4	1b979e0203a2ddfe98bf6c2c80c4af1ba437a80f
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CASS4 HDAC9 ENOX1 BCL11A	5.15e-04	179	92	4	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	BAL-Severe-Lymphocyte-B-B_cell-B_cell-B_activate-7\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL4A4 HDAC9 BCL11A LRRK1	5.26e-04	180	92	4	9f4bbaf6435c23e3e552ae22be8ea7884314192d
ToppCell	BAL-Severe-Lymphocyte-B-B_cell-B_cell\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL4A4 HDAC9 BCL11A LRRK1	5.26e-04	180	92	4	b465f2f8b0e9a2034a4f1272bb00c77439164dbf
ToppCell	10x5'-Lung-Myeloid_Dendritic-migDC\|Lung / Manually curated celltypes from each tissue	POGLUT1 ENOX1 BCL11A LRRK1	5.26e-04	180	92	4	e9e8992deb0beeee5548910e4616e7c990763d99
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	CASS4 MRPL55 DIAPH1 NAALADL2	5.26e-04	180	92	4	81d60f0fa9e3b5bfcec85139a0a49e9130145f0e
ToppCell	BAL-Severe-Lymphocyte-B-B_cell\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL4A4 HDAC9 BCL11A LRRK1	5.26e-04	180	92	4	c3c72531af5b9f7a7416727fe609dab5180e03b6
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FCSK ENOX1 MTOR POLR1B	5.26e-04	180	92	4	a682a5d55c612709c9ee9fa4289d6f8bef7fe1af
ToppCell	COPD-Myeloid-DC_Mature\|World / Disease state, Lineage and Cell class	POGLUT1 ENOX1 LRRK1 ABTB2	5.37e-04	181	92	4	675603a401d92cf9fdcd44e211ec899fa86a0d49
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOR1 BCL11B DIAPH1 STAT4	5.48e-04	182	92	4	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOR1 BCL11B DIAPH1 STAT4	5.48e-04	182	92	4	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	droplet-Spleen-nan-18m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LNPEP DIAPH1 DDX3X ITPR2	5.48e-04	182	92	4	eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCell	367C-Myeloid-Dendritic-cDC1\|367C / Donor, Lineage, Cell class and subclass (all cells)	HDAC9 CIB2 BCL11A BCL6	5.48e-04	182	92	4	6f5228ac47f9ab46d165740cf2655b5ba217acbe
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL4A4 HDAC9 TDRD15 BCL11A	5.60e-04	183	92	4	ffa831f67ed005f05d1b80ebc707e046fc08e22f
ToppCell	Basal\|World / shred by cell class for mouse tongue	COL7A1 BCL11B ITGA3 PLEC	5.60e-04	183	92	4	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CPEB3 CFAP70 NAALADL2 ITPR2	5.60e-04	183	92	4	31ab55d5f3639f5964541d5eae23044dbda3356e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A4 LNPEP BCL6 MAP3K1	5.60e-04	183	92	4	83592c332b1e82673f993d37c7f480befdc3dcda
ToppCell	RA-17._Lymphocyte\|World / Chamber and Cluster_Paper	CASS4 BCL11B NLRC5 STAT4	5.60e-04	183	92	4	6397f684a50346fc42cccb5afbe10350f4b2d9b0
ToppCell	COVID-19-APC-like\|COVID-19 / group, cell type (main and fine annotations)	HDAC9 BCL11A LRRK1 BCL6	5.60e-04	183	92	4	b8f5afaf9ff1b2b1bc60be58654d1b23859dafa9
Drug	Fluoxetine hydrochloride [59333-67-4]; Down 200; 11.6uM; MCF7; HT_HG-U133A	NCOR1 LIG4 LNPEP PCIF1 PLEC MVP ST14 SOS2	1.25e-06	197	91	8	5356_DN
Drug	Parthenolide [20554-84-1]; Down 200; 16.2uM; MCF7; HT_HG-U133A	IVNS1ABP PPP1R3C BCL11B B4GAT1 SULF1 POLR1B DDX3X	4.14e-06	163	91	7	2885_DN
Drug	Mebhydroline 1,5-naphtalenedisulfonate [6153-33-9]; Up 200; 4.8uM; PC3; HT_HG-U133A	COL7A1 CIB2 BCL11B PDE6B DYRK1A UPK2 ITPR2	1.34e-05	195	91	7	4211_UP
Drug	Betazole hydrochloride; Down 200; 27uM; PC3; HT_HG-U133A	CIB2 BCL11B MVP PIGO DDX3X ITPR2 RNF170	1.38e-05	196	91	7	6344_DN
Drug	thioridazine hydrochloride; Down 200; 10uM; HL60; HT_HG-U133A	B4GALT2 COL7A1 LNPEP BCL11A MVP PIGO MAP3K1	1.48e-05	198	91	7	6189_DN
Drug	(+/-)-thalidomide; Down 200; 100uM; MCF7; HG-U133A	NRG1 COL7A1 STAB2 ENOX1 DYRK1A BCL11A CHRNA3	1.48e-05	198	91	7	266_DN
Drug	Promazine hydrochloride [53-60-1]; Up 200; 12.4uM; MCF7; HT_HG-U133A	PDE6B CPEB3 DYRK1A EPS8L3 BCL11A MAP3K1 STAT4	1.58e-05	200	91	7	3833_UP
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A	ABCG4 TPST2 ENOX1 BCL6 ABTB2 STAT4	6.46e-05	171	91	6	3791_UP
Drug	Acetazolamide	PPP3CA DDX3X MAP3K1 ITPR2	6.97e-05	55	91	4	ctd:D000086
Drug	manganese	LIG4 SETMAR PPP3CA B4GAT1 MTOR DYRK1A POLR1B ITGA3 CHRNA3 CNDP1 RAD50 SOS2	7.25e-05	791	91	12	CID000023930
Drug	15d-PGJ2; Down 200; 10uM; MCF7; HT_HG-U133A_EA	IVNS1ABP PPP1R3C BCL11B B4GAT1 SULF1 MAP3K1	7.58e-05	176	91	6	1011_DN
Drug	osajin	HDAC9 MTOR	9.43e-05	4	91	2	CID000095168
Drug	Rapamycin; Up 200; 0.1uM; PC3; HT_HG-U133A	PPP1R3C DNAH3 PCIF1 BCL11A LRRK1 SOS2	1.22e-04	192	91	6	1221_UP
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A	COL7A1 PCIF1 LRRK1 PIGO DDX3X SOS2	1.26e-04	193	91	6	1284_DN
Drug	Gramine [87-52-5]; Up 200; 23uM; MCF7; HT_HG-U133A	COL4A4 PDE6B DYRK1A DDX3X ITPR2 SOS2	1.26e-04	193	91	6	4118_UP
Drug	Glimepiride [93479-97-1]; Down 200; 8.2uM; MCF7; HT_HG-U133A	PPP1R3C BCL11B PDE6B SULF1 MVP ITPR2	1.26e-04	193	91	6	4973_DN
Drug	Nitrofural [59-87-0]; Down 200; 20.2uM; MCF7; HT_HG-U133A	LIG4 STAB2 PLEC MVP DDX3X SOS2	1.33e-04	195	91	6	3320_DN
Drug	Meclozine dihydrochloride [1104-22-9]; Down 200; 8.6uM; PC3; HT_HG-U133A	LIG4 CIB2 ST14 PIGO XAB2 DDX3X	1.33e-04	195	91	6	4646_DN
Drug	15d-PGJ2; Down 200; 10uM; MCF7; HT_HG-U133A	PPP1R3C BCL11B SULF1 MVP MAP3K1 SOS2	1.33e-04	195	91	6	5228_DN
Drug	(S)-(-)-Cycloserine [339-72-0]; Down 200; 39.2uM; PC3; HT_HG-U133A	B4GALT2 PPP1R3C BCL11B SMARCD2 LRRK1 DDX3X	1.37e-04	196	91	6	3789_DN
Drug	Pentamidine isethionate [140-64-7]; Down 200; 6.8uM; HL60; HT_HG-U133A	PPP1R3C PCIF1 LRRK1 ST14 PIGO XAB2	1.37e-04	196	91	6	2473_DN
Drug	sodium 4-phenylbutyrate; Up 200; 100uM; HL60; HG-U133A	NRG1 STXBP5L SULF1 PLEC CHRNA3 SOS2	1.37e-04	196	91	6	363_UP
Drug	GSK-3 Inhibitor IX; Down 200; 0.5uM; PC3; HT_HG-U133A	DNAH3 LNPEP PCIF1 BCL11A PLEC SOS2	1.37e-04	196	91	6	6585_DN
Drug	(-)-Isoproterenol hydrochloride [5984-95-2]; Up 200; 16.2uM; MCF7; HT_HG-U133A	STAB2 STXBP5L LRRK1 PLEC CHRNA3 DDX3X	1.37e-04	196	91	6	3571_UP
Drug	CP-944629 [668990-94-1]; Up 200; 10uM; PC3; HT_HG-U133A	HDAC9 COL7A1 CIB2 BCL11A LRRK1 SMG6	1.37e-04	196	91	6	7502_UP
Drug	Letrozole [112809-51-5]; Up 200; 14uM; MCF7; HT_HG-U133A	LIG4 PLEC TRRAP PIGO DDX3X SOS2	1.37e-04	196	91	6	4824_UP
Drug	Methazolamide [554-57-4]; Down 200; 17uM; HL60; HT_HG-U133A	LIG4 PLEC ST14 PIGO MAP3K1 SOS2	1.37e-04	196	91	6	2733_DN
Drug	Scopolamine hydrochloride [55-16-3]; Up 200; 11.8uM; MCF7; HT_HG-U133A	ENOX1 DYRK1A EPS8L3 CHRNA3 DDX3X ITPR2	1.41e-04	197	91	6	3357_UP
Drug	Delcorine; Up 200; 8.4uM; HL60; HT_HG-U133A	COL7A1 STAB2 PDE6B CHRNA3 XAB2 ITPR2	1.45e-04	198	91	6	2178_UP
Drug	Napelline [5008-52-6]; Down 200; 11.2uM; PC3; HT_HG-U133A	BCL11B MTOR LRRK1 BCL6 MVP XAB2	1.45e-04	198	91	6	4486_DN
Drug	Reserpinic acid hydrochloride; Down 200; 9.2uM; PC3; HT_HG-U133A	COL7A1 DIAPH1 PLEC PIGO SMG6 SOS2	1.45e-04	198	91	6	6603_DN
Drug	thioridazine hydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A	TPST2 DNAH3 MTOR SULF1 PLEC LGALS3BP	1.45e-04	198	91	6	1655_DN
Drug	Atracurium besylate [64228-81-5]; Down 200; 3.2uM; PC3; HT_HG-U133A	B4GALT2 COL7A1 MRPS34 BCL11A PLEC RAD50	1.45e-04	198	91	6	1824_DN
Drug	Tadjakonine [11087-94-8]; Down 200; 7.4uM; HL60; HT_HG-U133A	PPP1R3C PCIF1 DYRK1A SPATA20 XAB2 ITPR2	1.49e-04	199	91	6	2165_DN
Drug	Catechin-(+,-) hydrate [7295-85-4]; Down 200; 13.8uM; PC3; HT_HG-U133A	CASS4 NRG1 COL7A1 ENOX1 DYRK1A CHRNA3	1.49e-04	199	91	6	4255_DN
Drug	Dacarbazine [4342-03-4]; Down 200; 22uM; MCF7; HT_HG-U133A	LIG4 BCL11B LNPEP SULF1 PCIF1 RNF170	1.49e-04	199	91	6	2754_DN
Drug	Articaine hydrochloride [23964-57-0]; Down 200; 12.4uM; HL60; HT_HG-U133A	B4GAT1 LNPEP SPATA20 LRRK1 BCL6 HTT	1.49e-04	199	91	6	3138_DN
Drug	Zimelidine dihydrochloride monohydrate [61129-30-4]; Up 200; 9.8uM; HL60; HG-U133A	ABCG4 CIB2 PLEC BCL6 PIGO RAD50	1.49e-04	199	91	6	2012_UP
Drug	Proxyphylline [603-00-9]; Up 200; 16.8uM; PC3; HT_HG-U133A	LIG4 ENOX1 DIAPH1 BCL6 PIGO RAD50	1.49e-04	199	91	6	7290_UP
Drug	LY 294002; Down 200; 10uM; PC3; HT_HG-U133A	LIG4 CIB2 BYSL TRRAP ABTB2 HTT	1.49e-04	199	91	6	1227_DN
Drug	PHA-00745360 [351320-33-7]; Down 200; 10uM; MCF7; HT_HG-U133A	LIG4 COL7A1 DNAH3 STAB2 CHRNA3 RAD50	1.53e-04	200	91	6	3907_DN
Drug	Etanidazole [22668-01-5]; Down 200; 18.6uM; HL60; HT_HG-U133A	B4GALT2 COL7A1 B4GAT1 MTOR PCIF1 XAB2	1.53e-04	200	91	6	2510_DN
Drug	dexamethasone; Down 200; 1uM; ssMCF7; HG-U133A	COL7A1 MXRA5 STAB2 BYSL BCL11A CHRNA3	1.53e-04	200	91	6	374_DN
Drug	Diloxanide furoate [3736-81-0]; Down 200; 12.2uM; PC3; HT_HG-U133A	HDAC9 CIB2 PDE6B ABTB2 DDX3X SOS2	1.53e-04	200	91	6	6679_DN
Drug	okadaic acid tetramethyl ether	RAF1 MTOR	1.57e-04	5	91	2	CID000147507
Disease	Intellectual Disability	FCSK BCL11B MTOR DIAPH1 BCL11A TRRAP DDX3X HTT CNDP1	8.45e-06	447	89	9	C3714756
Disease	Noonan-Like Syndrome With Loose Anagen Hair	RAF1 PPP1CB SOS2	2.48e-05	19	89	3	C3501846
Disease	Noonan syndrome-like disorder with loose anagen hair	RAF1 PPP1CB SOS2	2.48e-05	19	89	3	C1843181
Disease	Cardio-facio-cutaneous syndrome	RAF1 PPP1CB SOS2	2.48e-05	19	89	3	C1275081
Disease	Costello syndrome (disorder)	RAF1 PPP1CB SOS2	2.48e-05	19	89	3	C0587248
Disease	LEOPARD Syndrome	RAF1 PPP1CB SOS2	3.92e-05	22	89	3	C0175704
Disease	Etat Marbre	NRG1 HTT MICU1	4.50e-05	23	89	3	C0266487
Disease	Noonan Syndrome	RAF1 PPP1CB SOS2	5.13e-05	24	89	3	C0028326
Disease	Movement Disorders	NRG1 HTT MICU1	9.16e-05	29	89	3	C0026650
Disease	Ischemic stroke, large artery stroke	HDAC9 FAF1	1.34e-04	6	89	2	EFO_0005524, HP_0002140
Disease	mean reticulocyte volume	HDAC9 MTOR PCIF1 DYRK1A ZNF638 CC2D2A BCL11A TRRAP PIGO FAF1	1.48e-04	799	89	10	EFO_0010701
Disease	free cholesterol in small HDL measurement	TDRD15 PCIF1 NLRC5	1.62e-04	35	89	3	EFO_0022270
Disease	cholesteryl esters to total lipids in very large HDL percentage	TDRD15 PCIF1 NLRC5	1.76e-04	36	89	3	EFO_0022257
Disease	free cholesterol to total lipids in large VLDL percentage	TDRD15 PCIF1 NLRC5	1.91e-04	37	89	3	EFO_0022281
Disease	type 2 diabetes mellitus (implicated_via_orthology)	PPP1R3C BCL11B LNPEP BCL11A	2.93e-04	105	89	4	DOID:9352 (implicated_via_orthology)
Disease	Headache, glucose measurement	ZNF638 FAF1	3.19e-04	9	89	2	EFO_0004468, HP_0002315
Disease	cholesterol to total lipids in large VLDL percentage	TDRD15 BANF2 NLRC5	3.43e-04	45	89	3	EFO_0022236
Disease	neuroimaging measurement	HSPD1 HDAC9 NCOR1 BCL11B CC2D2A PLEC CAMTA1 FAF1 MAP3K1 HTT SMG6	3.70e-04	1069	89	11	EFO_0004346
Disease	Malignant neoplasm of breast	RAF1 NCOR1 NRG1 COL7A1 B4GAT1 MTOR NLRC5 BCL11A DDX3X MAP3K1 STAT4	3.85e-04	1074	89	11	C0006142
Disease	factor VIII measurement, coronary artery disease	HDAC9 TDRD15 STAB2 SMG6	3.87e-04	113	89	4	EFO_0001645, EFO_0004630
Disease	factor XI measurement, coronary artery disease	HDAC9 TDRD15 ZNF638 SMG6	4.14e-04	115	89	4	EFO_0001645, EFO_0004694
Disease	cholesteryl esters to total lipids in small VLDL percentage	TDRD15 BANF2 NLRC5	4.42e-04	49	89	3	EFO_0022256
Disease	von Willebrand factor measurement, coronary artery disease	HDAC9 TDRD15 STAB2 SMG6	4.57e-04	118	89	4	EFO_0001645, EFO_0004629
Disease	cholesterol to total lipids in small VLDL percentage	TDRD15 BANF2 NLRC5	4.97e-04	51	89	3	EFO_0022242
Disease	free cholesterol to total lipids in small HDL percentage	TDRD15 BANF2 PCIF1	4.97e-04	51	89	3	EFO_0022285
Disease	neutrophil percentage of leukocytes	HDAC9 ABCG4 LNPEP NLRC5 BCL6 FAF1 HTT RAD50	5.18e-04	610	89	8	EFO_0007990
Disease	phospholipids in IDL measurement	TDRD15 BANF2 PCIF1	5.27e-04	52	89	3	EFO_0022164
Disease	Prostatic Neoplasms	IVNS1ABP NCOR1 PPP2R2A STAB2 PPP3CA EPS8L3 ST14 MAP3K1	5.52e-04	616	89	8	C0033578
Disease	Malignant neoplasm of prostate	IVNS1ABP NCOR1 PPP2R2A STAB2 PPP3CA EPS8L3 ST14 MAP3K1	5.52e-04	616	89	8	C0376358
Disease	triglycerides to total lipids in very large VLDL percentage	TDRD15 BANF2 PCIF1	5.57e-04	53	89	3	EFO_0022340
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	BCL11B MTOR DDX3X	5.57e-04	53	89	3	C1961099
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	TDRD15 BANF2 PCIF1 NLRC5 HTT	5.73e-04	222	89	5	EFO_0008317, EFO_0020943
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	PPP2R2A ITPR2	5.82e-04	12	89	2	DOID:1441 (implicated_via_orthology)
Disease	triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	TDRD15 BANF2 PCIF1 NLRC5 FAF1	6.08e-04	225	89	5	EFO_0008317, EFO_0020947
Disease	cholesteryl esters to total lipids in large VLDL percentage	TDRD15 BANF2 PCIF1	6.55e-04	56	89	3	EFO_0022250
Disease	free cholesterol to total lipids in medium VLDL percentage	TDRD15 BANF2 PCIF1	6.90e-04	57	89	3	EFO_0022284
Disease	low density lipoprotein particle size measurement	TDRD15 BANF2 PCIF1	7.26e-04	58	89	3	EFO_0008593
Disease	adverse effect, response to xenobiotic stimulus	STAB2 BCL6 ST14	7.63e-04	59	89	3	EFO_0009658, GO_0009410
Disease	free cholesterol to total lipids in very large VLDL percentage	TDRD15 BANF2 PCIF1	7.63e-04	59	89	3	EFO_0022289
Disease	very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	TDRD15 BANF2 PCIF1 NLRC5 HTT	7.98e-04	239	89	5	EFO_0008317, EFO_0020945
Disease	coronary artery disease, plasminogen activator inhibitor 1 measurement	HDAC9 TDRD15 SMG6	9.24e-04	63	89	3	EFO_0001645, EFO_0004792
Disease	neurodegenerative disease (implicated_via_orthology)	BCL11B BCL11A HTT MICU1	9.88e-04	145	89	4	DOID:1289 (implicated_via_orthology)
Disease	T-Cell Lymphoma	BCL6 DDX3X	1.05e-03	16	89	2	C0079772
Disease	autism spectrum disorder (is_implicated_in)	DYRK1A BCL11A	1.05e-03	16	89	2	DOID:0060041 (is_implicated_in)
Disease	body mass index, type 2 diabetes mellitus	MTOR FAF1	1.05e-03	16	89	2	EFO_0004340, MONDO_0005148
Disease	Mammary Carcinoma, Human	RAF1 NCOR1 NRG1 COL7A1 B4GAT1 MTOR MAP3K1	1.06e-03	525	89	7	C4704874
Disease	Mammary Neoplasms, Human	RAF1 NCOR1 NRG1 COL7A1 B4GAT1 MTOR MAP3K1	1.06e-03	525	89	7	C1257931
Disease	Mammary Neoplasms	RAF1 NCOR1 NRG1 COL7A1 B4GAT1 MTOR MAP3K1	1.09e-03	527	89	7	C1458155
Disease	Microcephaly	LIG4 DYRK1A TRRAP	1.11e-03	67	89	3	C0025958
Disease	triglycerides:total lipids ratio, low density lipoprotein cholesterol measurement	TDRD15 BANF2 PCIF1 HTT	1.12e-03	150	89	4	EFO_0004611, EFO_0020947
Disease	cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	TDRD15 PCIF1	1.19e-03	17	89	2	EFO_0022232
Disease	low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	FCSK TDRD15 PCIF1 NLRC5	1.21e-03	153	89	4	EFO_0004611, EFO_0020946
Disease	Breast Carcinoma	RAF1 NCOR1 NRG1 COL7A1 B4GAT1 MTOR MAP3K1	1.22e-03	538	89	7	C0678222
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	TDRD15 BANF2 PCIF1 NLRC5 HTT	1.24e-03	264	89	5	EFO_0008317, EFO_0020944
Disease	Non-Small Cell Lung Carcinoma	RAF1 COL7A1 MXRA5 MTOR	1.29e-03	156	89	4	C0007131
Disease	tissue plasminogen activator measurement, coronary artery disease	HDAC9 TDRD15 SMG6	1.31e-03	71	89	3	EFO_0001645, EFO_0004791
Disease	lymphocyte count	HDAC9 ABCG4 NCOR1 BCL11B ZNF638 NLRC5 POLR1B PLEC FAF1 HTT SMG6 ITPR2	1.47e-03	1464	89	12	EFO_0004587
Disease	factor VIII measurement, Ischemic stroke	HDAC9 STAB2	1.49e-03	19	89	2	EFO_0004630, HP_0002140
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	TDRD15 BANF2 PCIF1 NLRC5 HTT	1.90e-03	291	89	5	EFO_0008317, EFO_0020946
Disease	Down syndrome (is_marker_for)	HSPD1 DYRK1A	2.00e-03	22	89	2	DOID:14250 (is_marker_for)
Disease	Ovarian Serous Adenocarcinoma	RAF1 TRRAP	2.18e-03	23	89	2	C1335177
Disease	sciatic neuropathy (implicated_via_orthology)	NRG1 MTOR	2.18e-03	23	89	2	DOID:11446 (implicated_via_orthology)
Disease	hepatocellular carcinoma (is_marker_for)	NRG1 MTOR NLRC5 DDX3X MAP3K1	2.21e-03	301	89	5	DOID:684 (is_marker_for)
Disease	left ventricular structural measurement	STAB2 FAF1 SMG6	2.42e-03	88	89	3	EFO_0008205
Disease	Hypertrophic obstructive cardiomyopathy	HSPD1 RAF1	2.58e-03	25	89	2	C4551472
Disease	Left Ventricular Hypertrophy	PPP3CA MTOR	2.58e-03	25	89	2	C0149721
Disease	sleep duration, low density lipoprotein cholesterol measurement	TDRD15 BANF2 HTT	2.66e-03	91	89	3	EFO_0004611, EFO_0005271
Disease	balding measurement	HDAC9 BANF2 MTOR BCL11A LRRK1 DENND5A FAF1 SMG6	2.72e-03	792	89	8	EFO_0007825
Disease	cholesterol to total lipids in medium LDL percentage	TDRD15 PCIF1	3.01e-03	27	89	2	EFO_0022238

Protein segments in the cluster

Peptide	Gene	Start	Entry
MRQMELEIRPLFLVP	SMG6	1236	Q86US8
PTVLTFPLEMAVFMR	ABCG4	441	Q9H172
MPLERVQRENPGVLM	B4GALT2	116	O60909
SQVRPREPMSVLMMA	CAMTA1	1351	Q9Y6Y1
PDDLERFVMVARMLP	CASS4	556	Q9NQ75
FLNLLPRVMFMTRPT	CHRNA3	346	P32297
TLRVPVFRPMDLMVE	PPP2R2A	151	P63151
VFRPMDLMVEASPRR	PPP2R2A	156	P63151
VVPAFEIRRARRMPM	B4GAT1	256	O43505
MMPLSEEAIRPYVSR	COL4A4	1551	P53420
LFAEMLMQRPVRLGQ	ADCK5	426	Q3MIX3
MLRLPTVFRQMRPVS	HSPD1	1	P10809
MLQRRMPQTFRDPAT	DYRK1A	76	Q13627
ILLLVRAMDPAVPNM	DIAPH1	241	O60610
VPALPSLTMRRMRES	RAF1	206	P04049
RDEMLGLVPMRQSII	RAD50	726	Q92878
MSPAIAIMQPILRFL	ITPR2	1911	Q14571
MAVSPFMEEERPLLL	NRG1	466	Q02297
RLPDMEMVINVRDYP	POGLUT1	121	Q8NBL1
RMLDMGFEPQIRRIV	DDX3X	351	O00571
IRFPMMLPEELFELQ	LGALS3BP	346	Q08380
SFLAPMRTPRARFQM	IVNS1ABP	396	Q9Y6Y0
LEICRRLEPYMAPSM	LRRK1	1721	Q38SD2
AFDRVLRLNPMAMEP	BCL11A	296	Q9H165
PIQIRRRLMMVAFLG	MICU1	26	Q9BPX6
RPIIISMNYSLPLRM	ITGA3	566	P26006
LERTVLDQQPIPMMD	PDE6B	746	P35913
AMERPLPMEQARYLE	EPS8L3	171	Q8TE67
MEPFTNDRLQLPRNM	LNPEP	1	Q9UIQ6
TMMVIFFLQRRSPPI	MTPAP	381	Q9NVV4
ERVLFAPMRMVTVPP	MVP	41	Q14764
LQMPSELPLSSRRMR	NLRC5	966	Q86WI3
SMEQIRRIMRPTDVP	PPP1CB	181	P62140
EPLTVRRMMDVLAPH	FCSK	1001	Q8N0W3
LRPVDMLLRSMFVTP	HTT	1646	P42858
ELRQVLMSMEPRRLE	GRID2IP	916	A4D2P6
DRVMRLNPMAIDSPA	BCL11B	346	Q9C0K0
MEREMLFIPSRQTVP	CC2D2A	281	Q9P2K1
PSMFREIMNDIPIRL	PCIF1	261	Q9H4Z3
PAMRLILPQLERERM	LIG4	66	P49917
MDNMSPRLRAFLSEP	BANF2	1	Q9H503
VPRPLRAVELAMIMD	CPEB3	556	Q8NE35
MDPMERKRLFIESIP	DNAH3	301	Q8TD57
RMPEELARRVKEMIP	CFAP70	481	Q5T0N1
LMPPLRISLIQDMRH	DENND5A	856	Q6IQ26
IKPPREEFLNSRMLM	BCL6	136	P41182
MDAPRRFPTLVQLMQ	KHDC3L	1	Q587J8
IILQRIRDMPYMDPS	COL7A1	1116	Q02388
PVMPSRQIVERQPRM	FAF1	86	Q9UNN5
ISPLDLRTDLRMMMP	HDAC9	21	Q9UKV0
LRTDLRMMMPVVDPV	HDAC9	26	Q9UKV0
EMVPARIRVLREMVP	CA5BP1	136	Q8WTZ4
IPEVRIMSIPNLRYM	DCTN4	306	Q9UJW0
ISANEIEMLLMRLPR	ENOX1	601	Q8TC92
LDRINERMPPRRDAM	PPP3CA	476	Q08209
RAIEMFMNKNPPARR	BYSL	131	Q13895
PVPLTYMIISRDVML	CRLS1	191	Q9UJA2
LRNLLPSNDPVVMEM	MTOR	111	P42345
VMLRVFQLEPSDPML	MAP3K1	361	Q13233
TEEPMLNVQRIRMEP	MRPS34	186	P82930
MVVMARLSRPERPDL	XAB2	1	Q9HCS7
IEPDMRRFFENLNPM	SOS2	981	Q07890
MSCTRMIQVLDPRPL	PPP1R3C	1	Q9UQK1
RLIVEMLEEFPQQMP	TDRD15	191	B5MCY1
SVIPPMMFDAEQRRV	NCOR1	401	O75376
QPRSIMERIMDLPTL	RNF170	166	Q96K19
RLAFRPQMDPRQLSM	SELENOO	491	Q9BVL4
EPNPLRSMMDNIRKR	SMIM18	76	P0DKX4
CEPNLLMIPVRIDSM	SETMAR	226	Q53H47
MFVLVEMVDTVRIPP	POLR3H	1	Q9Y535
RMEPRLLMPNLHQRL	REELD1	176	A0A1B0GV85
LRPMLDVNYLPLTDM	STXBP5L	1011	Q9Y2K9
MMDPFRKRLLVPQAQ	SMARCD2	111	Q92925
PPRMTLNNERPFMLL	ABTB2	406	Q8N961
MSLIIQMPELRENPF	CIB2	56	O75838
PVPRFRQELFRMMAV	CNDP1	66	Q96KN2
VMRMLFLEQPLPQAA	GTF2H4	56	Q92759
PRGAMRPEQEELVMV	TPST2	41	O60704
VMKRNEFLRLAMPQP	TRIM77	251	I1YAP6
PRRMLAMPIDLDTLS	MRPL55	71	Q7Z7F7
DPIPMQRTHMLERVT	STAT4	291	Q14765
FSERMRRVPVALPEM	SPATA20	676	Q8TB22
RVMAEERVVMLPPRA	ST14	171	Q9Y5Y6
SLPNLLMRLEQMPDY	STAB2	1136	Q8WWQ8
LLEVERSMQVYPMPQ	TEX13C	146	A0A0J9YWL9
SLQRVRRPVAMVMPA	PLEC	96	Q15149
REIPMSTLPRRNMES	UPK2	131	O00526
EPLMEMRLRDAPQHF	PIGO	991	Q8TEQ8
EKVIRMLIMPRRNFP	POLR1B	176	Q9H9Y6
MLIMPRRNFPIAMIR	POLR1B	181	Q9H9Y6
PMLPIHMEFTNILQR	SULF1	266	Q8IWU6
RQAMAILTPAVPARM	TRRAP	1921	Q9Y4A5
TPENMPLILRDIRMR	ZNF638	166	Q14966
RTLPASMLRNMPLLE	MXRA5	196	Q9NR99
APIRIRMLNDILQDM	NAALADL2	701	Q58DX5