Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsphingosine N-acyltransferase activity

CERS6 CERS4 CERS3

4.66e-087233GO:0050291
GeneOntologyMolecularFunctionN-acyltransferase activity

CERS6 CERS4 CERS3

2.13e-04102233GO:0016410
GeneOntologyMolecularFunctionacyltransferase activity, transferring groups other than amino-acyl groups

CERS6 CERS4 CERS3

2.48e-03238233GO:0016747
GeneOntologyBiologicalProcessceramide biosynthetic process

CERS6 CERS4 CERS3

6.24e-0573223GO:0046513
GeneOntologyBiologicalProcessceramide metabolic process

CERS6 CERS4 CERS3

2.29e-04113223GO:0006672
GeneOntologyBiologicalProcesssphingolipid biosynthetic process

CERS6 CERS4 CERS3

2.53e-04117223GO:0030148
DomainNPIP

NPIPB3 NPIPB15 NPIPB5 NPIPB13

2.08e-0914244IPR009443
DomainLag1/Lac1

CERS6 CERS4 CERS3

3.72e-086243IPR016439
DomainHomeobox

CERS6 DUXA SIX4 CERS4 CERS3 PROP1

4.04e-07234246PF00046
DomainHOMEOBOX_1

CERS6 DUXA SIX4 CERS4 CERS3 PROP1

4.25e-07236246PS00027
DomainHOX

CERS6 DUXA SIX4 CERS4 CERS3 PROP1

4.36e-07237246SM00389
DomainHomeobox_dom

CERS6 DUXA SIX4 CERS4 CERS3 PROP1

4.58e-07239246IPR001356
DomainHOMEOBOX_2

CERS6 DUXA SIX4 CERS4 CERS3 PROP1

4.58e-07239246PS50071
DomainTLC

CERS6 CERS4 CERS3

1.03e-0616243PS50922
DomainTLC-dom

CERS6 CERS4 CERS3

1.03e-0616243IPR006634
DomainTLC

CERS6 CERS4 CERS3

1.03e-0616243SM00724
DomainTRAM_LAG1_CLN8

CERS6 CERS4 CERS3

1.03e-0616243PF03798
Domain-

CERS6 DUXA SIX4 CERS4 CERS3 PROP1

1.23e-062832461.10.10.60
DomainHomeodomain-like

CERS6 DUXA SIX4 CERS4 CERS3 PROP1

3.10e-06332246IPR009057
DomainDH_1

ARHGEF28 ITSN1

2.95e-0363242PS00741
DomainRhoGEF

ARHGEF28 ITSN1

3.42e-0368242SM00325
DomainHTH_motif

DUXA PROP1

3.52e-0369242IPR000047
DomainDH_2

ARHGEF28 ITSN1

3.62e-0370242PS50010
DomainRhoGEF

ARHGEF28 ITSN1

3.62e-0370242PF00621
Domain-

ARHGEF28 ITSN1

3.73e-03712421.20.900.10
DomainDH-domain

ARHGEF28 ITSN1

3.73e-0371242IPR000219
DomainPH_dom-like

ARHGEF28 NBEAL1 ITSN1

1.67e-02426243IPR011993
PathwayWP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES

CERS6 CERS4 CERS3

2.21e-0622173M45544
PathwayWP_SPHINGOLIPID_METABOLISM_OVERVIEW

CERS6 CERS4 CERS3

3.30e-0625173MM15931
PathwayWP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY

CERS6 CERS4 CERS3

3.72e-0626173MM15892
PathwayWP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY

CERS6 CERS4 CERS3

3.72e-0626173M39784
PathwayWP_SPHINGOLIPID_METABOLISM_OVERVIEW

CERS6 CERS4 CERS3

4.19e-0627173M39863
PathwayREACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS

CERS6 CERS4 CERS3

4.19e-0627173MM14646
PathwayWP_SPHINGOLIPID_PATHWAY

CERS6 CERS4 CERS3

5.80e-0630173M39501
PathwayREACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS

CERS6 CERS4 CERS3

1.10e-0537173M554
PathwayREACTOME_SPHINGOLIPID_METABOLISM

CERS6 CERS4 CERS3

1.71e-0492173MM15086
PathwayREACTOME_SPHINGOLIPID_METABOLISM

CERS6 CERS4 CERS3

2.68e-04107173M14857
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

ARHGEF28 ITSN1

8.89e-0437172MM15022
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

ARHGEF28 ITSN1

1.15e-0342172M27308
PathwayWP_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION

TRAF3IP3 LYL1

2.56e-0363172M39366
PathwayREACTOME_EPH_EPHRIN_SIGNALING

ARHGEF28 ITSN1

2.72e-0365172MM14911
PathwayREACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING

LINGO1 ITSN1

4.61e-0385172MM14746
PathwayREACTOME_EPH_EPHRIN_SIGNALING

ARHGEF28 ITSN1

5.38e-0392172M27201
PathwayREACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING

LINGO1 ITSN1

5.96e-0397172M9400
Pubmed

Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.

CERS6 CERS4 CERS3

2.08e-09429312912983
Pubmed

Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis?

CERS6 CERS4 CERS3

2.08e-09429312297269
Pubmed

Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.

CERS6 CERS4 CERS3

5.21e-09529326887952
Pubmed

Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.

CERS6 CERS4 CERS3

1.04e-08629317977534
Pubmed

Oxidized phospholipids induce ceramide accumulation in RAW 264.7 macrophages: role of ceramide synthases.

CERS6 CERS4 CERS3

1.04e-08629323936132
Pubmed

Ceramide synthesis regulates T cell activity and GVHD development.

CERS6 CERS4

6.71e-07229228515365
Pubmed

Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.

CERS6 CERS4 CERS3

1.50e-062729323096701
Pubmed

Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.

CERS6 CERS4 CERS3

1.50e-062729325269881
Pubmed

Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.

CERS6 CERS4 CERS3

1.88e-062929338485951
Pubmed

Divergent origins and concerted expansion of two segmental duplications on chromosome 16.

NPIPB3 NPIPB5

2.01e-06329211948212
Pubmed

The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.

CERS6 CERS4

4.02e-06429223538298
Pubmed

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.

CERS6 CERS4

6.70e-06529215823095
Pubmed

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

TENM4 SYNE1

1.14e-041929218711365
Pubmed

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.

SYNE1 ITSN1

1.53e-042229212812986
Cytoband16p12.2

NPIPB3 NPIPB4 NPIPB5

1.74e-063729316p12.2
CytobandEnsembl 112 genes in cytogenetic band chr16p12

NPIPB3 NPIPB4 NPIPB5

1.76e-04172293chr16p12
Cytoband16p11.2

NPIPB13 NPIPB12 NPIPB11

2.39e-0419129316p11.2
CytobandEnsembl 112 genes in cytogenetic band chr16p11

NPIPB13 NPIPB12 NPIPB11

7.14e-04278293chr16p11
Cytoband19p13.2

LYL1 CERS4

9.20e-0322929219p13.2
GeneFamilyCERS class homeoboxes

CERS6 CERS4 CERS3

5.80e-096133530
GeneFamilyPRD class homeoboxes and pseudogenes

DUXA PROP1

1.93e-0392132521
CoexpressionJINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_DN

NPIPB3 NPIPB15 NPIPB13 NPIPB12 NPIPB11

1.86e-05302295M38975
CoexpressionJINESH_BLEBBISHIELD_VS_LIVE_CONTROL_UP

NPIPB3 NPIPB15 NPIPB13 NPIPB12 NPIPB11

5.56e-05380295M38974
CoexpressionAtlasMesoderm Day 30-method_NA_vs_Mesoderm Day 30-method_plasmid-Confounder_removed-fold2.0_adjp0.05

NPIPB3 NPIPB4 LINGO1 NPIPB5 NPIPB13

7.71e-05371265PCBC_ratio_MESO-30_from-ESC_vs_MESO-30_from-plasmid_cfr-2X-p05
CoexpressionAtlasMesoderm Day 30-reprogram_NA_vs_Mesoderm Day 30-reprogram_OSKM - NLT-Confounder_removed-fold2.0_adjp0.05

NPIPB3 NPIPB4 LINGO1 NPIPB5 NPIPB13

7.71e-05371265PCBC_ratio_MESO-30_from-ESC_vs_MESO-30_from-OSKM - NLT_cfr-2X-p05
CoexpressionAtlasMESO-30 blastocyst_vs_MESO-30 fibroblast-Confounder_removed-fold2.0_adjp0.05

NPIPB3 NPIPB4 LINGO1 NPIPB5 NPIPB13

7.71e-05371265PCBC_ratio_MESO-30 blastocyst_vs_MESO-30 fibroblast_cfr-2X-p05
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SFI1 NPIPB4 NPIPB5 SYNE1 USP24

1.51e-071932959337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SFI1 NPIPB4 NPIPB5 SYNE1 USP24

1.75e-07199295f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

NPIPB4 NPIPB5 SYNE1 USP24

7.77e-0619729457ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellmild-low-quality_cells|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SFI1 ARHGEF28 NPIPB5 SYNE1

7.77e-06197294e4331969bd911d1ebb5453f40a7057297b5389b4
ComputationalNeighborhood of ATM

SFI1 TRAF3IP3

5.76e-0430132GNF2_ATM
Diseaselevel of Sphingomyelin (d38:1) in blood serum

CERS4 USP24

2.95e-0430252OBA_2045180
Diseasefish consumption measurement

TENM4 TUSC1

1.35e-0364252EFO_0010139
DiseaseCleft palate, cleft lip

SFI1 TRAF3IP3 TENM4

1.65e-03279253EFO_0003959, HP_0000175
Diseaselate-onset Alzheimers disease

TENM4 LINGO1 TUSC1

1.88e-03292253EFO_1001870
Diseaseamino acid measurement

TENM4 ARHGEF28 TUSC1 SYNE1

2.38e-03678254EFO_0005134
Diseaseattention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia

TENM4 SYNE1

3.31e-03101252EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
DiseaseRS-10-hydroxywarfarin to RS-warfarin ratio measurement

CERS6 TENM4

3.91e-03110252EFO_0803335
DiseaseDrug Use Disorders

CERS6 SYNE1

4.26e-03115252C0013222
DiseaseDrug Dependence

CERS6 SYNE1

4.26e-03115252C1510472
DiseaseDrug habituation

CERS6 SYNE1

4.26e-03115252C0013170
DiseaseSubstance Dependence

CERS6 SYNE1

4.26e-03115252C0038580
DiseaseSubstance Use Disorders

CERS6 SYNE1

4.26e-03115252C0038586
DiseaseSubstance-Related Disorders

CERS6 SYNE1

4.26e-03115252C0236969
DiseaseDrug abuse

CERS6 SYNE1

4.26e-03115252C0013146
DiseaseOrganic Mental Disorders, Substance-Induced

CERS6 SYNE1

4.26e-03115252C0029231
DiseasePrescription Drug Abuse

CERS6 SYNE1

4.26e-03115252C4316881
Diseasemean reticulocyte volume

TRAF3IP3 LYL1 CERS4 ITSN1

4.29e-03799254EFO_0010701
DiseaseSubstance abuse problem

CERS6 SYNE1

4.33e-03116252C0740858
Diseasesleep quality

TENM4 TUSC1

4.48e-03118252EFO_0005272
Diseasebipolar I disorder

TENM4 SYNE1

6.33e-03141252EFO_0009963

Protein segments in the cluster

PeptideGeneStartEntry
LQQTQRWFRRRRNQD

CERS4

111

Q9HA82
NQRRSRQWENRFIAL

NBEAL1

311

Q6ZS30
TDVQQRAWRSNRRRQ

NPIPB3

101

Q92617
TDVQQRAWRSNRRRQ

NPIPB12

101

F8W0I5
QRRWLRRCEQQQRAQ

ARHGEF28

1451

Q8N1W1
FRRRWRLNFNRQQPT

LINGO1

381

Q96FE5
TDVQQRAWRSNRRRQ

NPIPB5

101

A8MRT5
TDVQQRAWRSNRRRQ

NPIPB4

101

C9JG80
TDVQQRAWRSNRSRQ

NPIPB15

101

A6NHN6
TDVQQRAWRSNRRRQ

NPIPB11

101

E5RHQ5
RQVERWFRSRRNQER

CERS3

111

Q8IU89
LERQRQLEWERNRRQ

ITSN1

441

Q15811
RSIQRWFRQRRNQEK

CERS6

111

Q6ZMG9
RRVFTNSRERWRQQN

LYL1

151

P12980
QIWFQNRRSRLLLQR

DUXA

146

A6NLW8
TDVQQRAWRSNRRRQ

NPIPB13

101

A6NJU9
QWRQQLAARRQEQRA

SFI1

826

A8K8P3
SNQWQGVIRRAQQRR

SYNE1

7541

Q8NF91
QRRARRQSQFNEVNQ

SSMEM1

126

Q8WWF3
TQRQRRCRGQRWTVQ

RPP21

76

Q9H633
QVSNWFKNRRQRDRN

SIX4

266

Q9UIU6
QLQRARLQQFFRRRN

TRAF3IP3

56

Q9Y228
QRLQGREANWRQTRR

MPV17L

36

Q2QL34
ERWQQEQEQRRRSRA

KCTD15

151

Q96SI1
QRAVRQAWAREQQRL

TENM4

2696

Q6N022
ARQREQEARLRQQWE

TCHP

21

Q9BT92
ARIQVWFQNRRAKQR

PROP1

111

O75360
RQNNQIRRWSSAQAR

USP24

2321

Q9UPU5
EWDRQNARLRQENAR

TUSC1

81

Q2TAM9