Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glutathione binding	GSTM1 GSTM2 GSTM4	4.84e-05	18	80	3	GO:0043295
GeneOntologyMolecularFunction	oligopeptide binding	GSTM1 GSTM2 GSTM4	6.72e-05	20	80	3	GO:1900750
GeneOntologyMolecularFunction	glutathione transferase activity	GSTM1 GSTM2 GSTM4	2.10e-04	29	80	3	GO:0004364
GeneOntologyMolecularFunction	sulfur compound binding	GSTM1 GSTM2 GSTM4 P2RX1 ACADM ADAMTS3 PCOLCE	3.14e-04	323	80	7	GO:1901681
GeneOntologyMolecularFunction	protein kinase regulator activity	SPRED2 DEPTOR APC SAV1 TESC FAF1	6.06e-04	259	80	6	GO:0019887
GeneOntologyBiologicalProcess	nitrobenzene metabolic process	GSTM1 GSTM2 GSTM4	2.24e-07	4	80	3	GO:0018916
GeneOntologyBiologicalProcess	positive regulation of bone mineralization	ANO6 WNT10B OSR2 ATP2B1	3.89e-05	49	80	4	GO:0030501
GeneOntologyBiologicalProcess	positive regulation of biomineral tissue development	ANO6 WNT10B OSR2 ATP2B1	8.67e-05	60	80	4	GO:0070169
GeneOntologyBiologicalProcess	positive regulation of ossification	ANO6 WNT10B OSR2 ATP2B1	1.26e-04	66	80	4	GO:0045778
GeneOntologyBiologicalProcess	cellular detoxification of nitrogen compound	GSTM1 GSTM2	1.47e-04	5	80	2	GO:0070458
GeneOntologyBiologicalProcess	detoxification of nitrogen compound	GSTM1 GSTM2	1.47e-04	5	80	2	GO:0051410
GeneOntologyBiologicalProcess	long-chain fatty acid biosynthetic process	GSTM1 GSTM2 GSTM4	1.91e-04	29	80	3	GO:0042759
GeneOntologyBiologicalProcess	negative regulation of cyclin-dependent protein serine/threonine kinase activity	LATS2 APC CDK5RAP1	1.91e-04	29	80	3	GO:0045736
GeneOntologyBiologicalProcess	negative regulation of cyclin-dependent protein kinase activity	LATS2 APC CDK5RAP1	2.12e-04	30	80	3	GO:1904030
Domain	GST_mu	GSTM1 GSTM2 GSTM4	7.52e-07	5	80	3	IPR003081
Domain	Prepro-melanin_conc_hormone	PMCHL1 PMCHL2	5.42e-05	3	80	2	IPR005456
Domain	Pro-MCH	PMCHL1 PMCHL2	5.42e-05	3	80	2	PF05824
Domain	GST_N	GSTM1 GSTM2 GSTM4	1.10e-04	22	80	3	PF02798
Domain	GST_NTER	GSTM1 GSTM2 GSTM4	1.10e-04	22	80	3	PS50404
Domain	GST_C	GSTM1 GSTM2 GSTM4	1.83e-04	26	80	3	IPR004046
Domain	GST_C	GSTM1 GSTM2 GSTM4	1.83e-04	26	80	3	PF00043
Domain	Glutathione_S-Trfase_N	GSTM1 GSTM2 GSTM4	2.06e-04	27	80	3	IPR004045
Domain	GST_CTER	GSTM1 GSTM2 GSTM4	4.11e-04	34	80	3	PS50405
Domain	PDZ	DEPTOR PARD6A AFDN SIPA1 PRX	4.35e-04	148	80	5	SM00228
Domain	-	DEPTOR PARD6A AFDN SIPA1 PRX	4.63e-04	150	80	5	2.30.42.10
Domain	PDZ	DEPTOR PARD6A AFDN SIPA1 PRX	4.77e-04	151	80	5	PS50106
Domain	PDZ	DEPTOR PARD6A AFDN SIPA1 PRX	4.92e-04	152	80	5	IPR001478
Domain	Glutathione-S-Trfase_C-like	GSTM1 GSTM2 GSTM4	6.19e-04	39	80	3	IPR010987
Domain	-	GSTM1 GSTM2 GSTM4	6.19e-04	39	80	3	1.20.1050.10
Domain	rSAM	TYW1B CDK5RAP1	6.40e-04	9	80	2	IPR007197
Domain	Radical_SAM	TYW1B CDK5RAP1	6.40e-04	9	80	2	PF04055
Domain	GST_C_3	GSTM1 GSTM4	7.97e-04	10	80	2	PF14497
Domain	TF_T-box	TBX15 TBX10	2.36e-03	17	80	2	IPR001699
Domain	TBOX	TBX15 TBX10	2.36e-03	17	80	2	SM00425
Domain	TF_T-box_CS	TBX15 TBX10	2.36e-03	17	80	2	IPR018186
Domain	-	TBX15 TBX10	2.36e-03	17	80	2	2.60.40.820
Domain	TBOX_3	TBX15 TBX10	2.36e-03	17	80	2	PS50252
Domain	T-box	TBX15 TBX10	2.36e-03	17	80	2	PF00907
Domain	TBOX_1	TBX15 TBX10	2.36e-03	17	80	2	PS01283
Domain	TBOX_2	TBX15 TBX10	2.36e-03	17	80	2	PS01264
Domain	Thioredoxin-like_fold	GSTM1 GSTM2 GSTM4 FAF1	2.49e-03	132	80	4	IPR012336
Domain	PDZ	PARD6A AFDN SIPA1 PRX	3.16e-03	141	80	4	PF00595
Pubmed	Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution.	GSTM1 GSTM2 GSTM4	1.26e-08	3	82	3	16549767
Pubmed	Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript.	GSTM1 GSTM2 GSTM4	5.04e-08	4	82	3	8373352
Pubmed	Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1.	GSTM1 GSTM2 GSTM4	1.26e-07	5	82	3	19856098
Pubmed	Glutathione S-transferase variants and hypertension.	GSTM1 GSTM2 GSTM4	1.26e-07	5	82	3	18551009
Pubmed	Purification and characterization of eight glutathione S-transferase isoenzymes of hamster. Comparison of subunit composition of enzymes from liver, kidney, testis, pancreas and trachea.	GSTM1 GSTM2 GSTM4	2.51e-07	6	82	3	1530570
Pubmed	Structure of human glutathione S-transferase class Mu genes.	GSTM2 GSTM4	5.49e-06	2	82	2	2006920
Pubmed	Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion.	GSTM1 GSTM4	5.49e-06	2	82	2	3174634
Pubmed	Human genes for glutathione S-transferases.	GSTM1 GSTM2	5.49e-06	2	82	2	6500576
Pubmed	Cloning and expression of a novel Mu class murine glutathione transferase isoenzyme.	GSTM2 GSTM4	5.49e-06	2	82	2	12069689
Pubmed	Functional compensation of glutathione S-transferase M1 (GSTM1) null by another GST superfamily member, GSTM2.	GSTM1 GSTM2	5.49e-06	2	82	2	24048194
Pubmed	Birth of two chimeric genes in the Hominidae lineage.	PMCHL1 PMCHL2	5.49e-06	2	82	2	11181993
Pubmed	Epithelial Src homology region 2 domain-containing phosphatase-1 restrains intestinal growth, secretory cell differentiation, and tumorigenesis.	PTPN6 APC	5.49e-06	2	82	2	28465325
Pubmed	Structure and expression of the variant melanin-concentrating hormone genes: only PMCHL1 is transcribed in the developing human brain and encodes a putative protein.	PMCHL1 PMCHL2	5.49e-06	2	82	2	11070051
Pubmed	Identification of residues in glutathione transferase capable of driving functional diversification in evolution. A novel approach to protein redesign.	GSTM1 GSTM2	5.49e-06	2	82	2	12486119
Pubmed	Quantitative assessment of the effect of glutathione S-transferase genes GSTM1 and GSTT1 on hepatocellular carcinoma risk.	GSTM1 GSTM2	5.49e-06	2	82	2	24399650
Pubmed	The redox state of cytochrome c modulates resistance to methotrexate in human MCF7 breast cancer cells.	GSTM1 GSTM2	5.49e-06	2	82	2	23675469
Pubmed	Impact of domain interchange on conformational stability and equilibrium folding of chimeric class micro glutathione transferases.	GSTM1 GSTM2	5.49e-06	2	82	2	12192076
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	FOXRED2 ACADM ANO6 BMS1 DAD1 SAV1 PUM3 ATP2B1 DYNC1I2 FTSJ3	1.13e-05	754	82	10	33060197
Pubmed	Assignment of the human pro-melanin-concentrating hormone gene (PMCH) to chromosome 12q23-q24 and two variant genes (PMCH1 and PMCHL2) to chromosome 5p14 and 5q12-q13.	PMCHL1 PMCHL2	1.64e-05	3	82	2	8188237
Pubmed	Deduced amino acid sequence, gene structure and chromosomal location of a novel human class Mu glutathione S-transferase, GSTM4.	GSTM1 GSTM4	1.64e-05	3	82	2	8471052
Pubmed	Altered growth characteristics of skin fibroblasts from wild-derived mice, and genetic loci regulating fibroblast clone size.	GSTM2 GSTM4	1.64e-05	3	82	2	16842493
Pubmed	The structure of two murine class-mu glutathione transferase genes coordinately induced by butylated hydroxyanisole.	GSTM1 GSTM4	1.64e-05	3	82	2	8512323
Pubmed	Genetic susceptibility, residential radon, and lung cancer in a radon prone area.	GSTM1 GSTM2	1.64e-05	3	82	2	24852519
Pubmed	Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage.	GSTM1 GSTM2	1.64e-05	3	82	2	32574561
Pubmed	Characterization of the human class Mu glutathione S-transferase gene cluster and the GSTM1 deletion.	GSTM1 GSTM2	1.64e-05	3	82	2	9452477
Pubmed	Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils.	GSTM1 GSTM2	1.64e-05	3	82	2	21046276
Pubmed	Primate-specific spliced PMCHL RNAs are non-protein coding in human and macaque tissues.	PMCHL1 PMCHL2	1.64e-05	3	82	2	19068116
Pubmed	A common variant in the glutathione S transferase gene is associated with elevated markers of inflammation and lipid peroxidation in subjects with diabetes mellitus.	GSTM1 GSTM2	1.64e-05	3	82	2	16002077
Pubmed	Glutathione-S-transferases and Chemotherapy Resistance of Hodgkin's Lymphoma Cell Lines.	GSTM1 GSTM4	1.64e-05	3	82	2	27466493
Pubmed	The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor.	GSTM1 GSTM2	3.28e-05	4	82	2	22406107
Pubmed	Reduced intestinal tumorigenesis in APCmin mice lacking melanin-concentrating hormone.	APC PMCHL2	3.28e-05	4	82	2	22848656
Pubmed	Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13.	GSTM1 GSTM2	3.28e-05	4	82	2	8317488
Pubmed	Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung function.	GSTM2 GSTM4	3.28e-05	4	82	2	19151192
Pubmed	NEDD4 controls intestinal stem cell homeostasis by regulating the Hippo signalling pathway.	LATS2 SAV1	3.28e-05	4	82	2	25692647
Pubmed	AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1.	AFDN SIPA1	3.28e-05	4	82	2	12590145
Pubmed	Deptor Is a Novel Target of Wnt/β-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth.	DEPTOR APC	3.28e-05	4	82	2	29666061
Pubmed	Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.	GSTM1 GSTM2 GSTM4	4.90e-05	30	82	3	20200426
Pubmed	FAM deubiquitylating enzyme is essential for preimplantation mouse embryo development.	AFDN FAF1	5.47e-05	5	82	2	11731229
Pubmed	Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development.	TBX15 WNT10B	5.47e-05	5	82	2	17071745
Pubmed	Ajuba LIM proteins are negative regulators of the Hippo signaling pathway.	LATS2 SAV1	8.19e-05	6	82	2	20303269
Pubmed	The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.	LATS2 SAV1	8.19e-05	6	82	2	15688006
Pubmed	In vitro reconstitution of a highly processive recombinant human dynein complex.	DYNC1H1 DYNC1I2	8.19e-05	6	82	2	24986880
Pubmed	Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells.	AFDN SIPA1	8.19e-05	6	82	2	19589776
Pubmed	Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling.	LATS2 SAV1	8.19e-05	6	82	2	30266805
Pubmed	UHRF2 promotes intestinal tumorigenesis through stabilization of TCF4 mediated Wnt/β-catenin signaling.	APC UHRF2	8.19e-05	6	82	2	32372448
Pubmed	Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium.	SLC12A3 APC	8.19e-05	6	82	2	15550389
Pubmed	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	CWF19L2 SPRED2 DAD1 CDK5RAP1 DYNC1H1	9.64e-05	193	82	5	20677014
Pubmed	Hippo signaling impedes adult heart regeneration.	LATS2 SAV1	1.14e-04	7	82	2	24255096
Pubmed	β-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis.	APC SAV1	1.14e-04	7	82	2	26193883
Pubmed	A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system.	DYNC1H1 DYNC1I2	1.14e-04	7	82	2	11163259
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	GTF3C1 ACADM TONSL APC CDK5RAP1 AFDN FHIP2A SBNO2	1.51e-04	650	82	8	38777146
Pubmed	Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells.	PARD6A AFDN	1.52e-04	8	82	2	12203721
Pubmed	A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members if the T-box family.	TBX15 TBX10	1.52e-04	8	82	2	9503012
Pubmed	Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.	LATS2 APC	1.52e-04	8	82	2	32259481
Pubmed	Pervasive translational regulation of the cell signalling circuitry underlies mammalian development.	LATS2 SAV1	1.52e-04	8	82	2	28195124
Pubmed	Hippo pathway-dependent and -independent roles of RASSF6.	LATS2 SAV1	1.52e-04	8	82	2	19797269
Pubmed	HIV-1 uncoating is facilitated by dynein and kinesin 1.	DYNC1H1 DYNC1I2	1.52e-04	8	82	2	25231297
Pubmed	AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.	LATS2 SAV1	1.52e-04	8	82	2	34404733
Pubmed	HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.	DYNC1H1 DYNC1I2	1.52e-04	8	82	2	25818806
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	SMG7 SYNJ1 APC AFDN FHIP2A DYNC1H1 DYNC1I2 FAM83B FTSJ3	1.82e-04	853	82	9	28718761
Pubmed	Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis.	GSTM1 GSTM2	1.96e-04	9	82	2	18065725
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	SNCAIP APC ATIC SIPA1 DYNC1H1 DYNC1I2	2.13e-04	360	82	6	33111431
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	ABCB10 ACADM RNASEH2C DAD1 ATIC ATP2B1 DYNC1H1 FAF1 DYNC1I2	2.26e-04	878	82	9	37223481
Pubmed	PEX14 is required for microtubule-based peroxisome motility in human cells.	FAR1 DYNC1H1 DYNC1I2	2.87e-04	54	82	3	21525035
Pubmed	Synaptic vesicle trafficking and Parkinson's disease.	SNCAIP SYNJ1	2.98e-04	11	82	2	21563316
Pubmed	Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon.	ENPP6 APC	2.98e-04	11	82	2	34222248
Pubmed	Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2.	LATS2 SAV1	2.98e-04	11	82	2	28486106
Pubmed	The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.	GSTM1 TIA1 SYNJ1 PYGM ATP2B1 DYNC1H1 DYNC1I2	3.32e-04	552	82	7	36293380
Pubmed	BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.	CWF19L2 PYGM DYNC1H1	3.37e-04	57	82	3	27433848
Pubmed	WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy.	LATS2 SAV1	3.57e-04	12	82	2	35429439
Pubmed	Multiple glycolytic enzymes are tightly bound to the fibrous sheath of mouse spermatozoa.	GSTM1 AKAP3	3.57e-04	12	82	2	16687649
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	LATS2 SPRED2 DEPTOR ANO6 PLEKHN1 ATP2B1 FAM83B	3.99e-04	569	82	7	30639242
Pubmed	Cytoplasmic dynein nomenclature.	DYNC1H1 DYNC1I2	4.21e-04	13	82	2	16260502
Pubmed	DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.	LATS2 SAV1	4.91e-04	14	82	2	28087714
Pubmed	BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures.	DYNC1H1 DYNC1I2	4.91e-04	14	82	2	22956769
Pubmed	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	GSTM1 GSTM4 CYP8B1	5.19e-04	66	82	3	19898482
Pubmed	β-catenin regulates the formation of multiple nephron segments in the mouse kidney.	SLC12A3 OSR2	5.65e-04	15	82	2	31685872
Pubmed	Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.	SLC18A3 GRIN1	5.65e-04	15	82	2	18227507
Pubmed	Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis.	TBX15 OSR2	6.45e-04	16	82	2	33482080
Pubmed	Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer.	LATS2 APC	6.45e-04	16	82	2	32730753
Pubmed	A crucial role of WW45 in developing epithelial tissues in the mouse.	LATS2 SAV1	6.45e-04	16	82	2	18369314
Pubmed	Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC.	SPRED2 SMG7 TIA1 SAV1 AFDN	6.59e-04	293	82	5	31741433
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	GTF3C1 PUM3 AFDN ATIC FAR1 ATP2B1 DYNC1H1 FAM83B FTSJ3	6.88e-04	1024	82	9	24711643
Pubmed	FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals.	CDH22 SLC18A3	8.20e-04	18	82	2	12682014
Pubmed	De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity.	PARD6A AFDN	8.20e-04	18	82	2	23487309
Pubmed	Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.	PTPN6 SLC18A3 BMS1	8.46e-04	78	82	3	19204726
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SPRED2 SYNJ1 DAD1 APC AFDN ATIC WRAP53 MED13 DYNC1H1 FAF1	8.76e-04	1285	82	10	35914814
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	GTF3C1 BMS1 PUM3 AFDN ATIC DYNC1H1 FTSJ3	8.97e-04	653	82	7	22586326
Pubmed	ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis.	PARD6A AFDN	9.15e-04	19	82	2	35177595
Pubmed	Fyn Regulates Binding Partners of Cyclic-AMP Dependent Protein Kinase A.	GSTM1 GSTM2 DYNC1H1	9.78e-04	82	82	3	30274258
Pubmed	Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites.	DAD1 GRIN1	1.01e-03	20	82	2	16679559
Pubmed	A Wnt-bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis.	WNT10B APC	1.01e-03	20	82	2	22234613
Pubmed	Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism.	TBX15 DEPTOR	1.01e-03	20	82	2	26299309
Pubmed	TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development.	TBX15 OSR2	1.01e-03	20	82	2	36542062
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TIA1 SYNJ1 TYW1B RNASEH2C APC ZFYVE1 ATXN1L ATP2B1 SBNO2	1.03e-03	1084	82	9	11544199
Pubmed	Ski regulates Hippo and TAZ signaling to suppress breast cancer progression.	LATS2 SAV1 DYNC1H1	1.05e-03	84	82	3	25670202
Pubmed	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	GSTM1 TBX15 OSR2 TBX10 ATIC	1.14e-03	331	82	5	20634891
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	GSTM1 GSTM2 GSTM4 ABCB10	1.15e-03	193	82	4	19343046
Pubmed	Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size.	LATS2 SAV1	1.23e-03	22	82	2	21512031
Pubmed	The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.	PARD6A AFDN	1.23e-03	22	82	2	27521426
Cytoband	1p13.3	GSTM1 GSTM2 GSTM4	2.64e-04	69	82	3	1p13.3
GeneFamily	Glutathione S-transferases	GSTM1 GSTM2 GSTM4	4.94e-05	25	52	3	567
GeneFamily	PDZ domain containing	DEPTOR PARD6A AFDN SIPA1 PRX	7.43e-05	152	52	5	1220
GeneFamily	Dyneins, cytoplasmic	DYNC1H1 DYNC1I2	6.20e-04	13	52	2	538
GeneFamily	T-boxes	TBX15 TBX10	1.21e-03	18	52	2	766
CoexpressionAtlas	DevelopingGonad_e16.5_testes_emap-8444_k-means-cluster#4_top-relative-expression-ranked_100	GSTM1 GSTM2 OSR2 TESC	3.93e-06	29	79	4	gudmap_developingGonad_e16.5_testes_100_k4
CoexpressionAtlas	DevelopingGonad_e16.5_testes_emap-8444_top-relative-expression-ranked_100	GSTM1 GSTM2 OSR2 TESC FAF1	1.14e-05	79	79	5	gudmap_developingGonad_e16.5_testes_100
CoexpressionAtlas	PP_MEP_top-relative-expression-ranked_500_k-means-cluster#3	PTPN6 P2RX1 SNX20 TESC DOK2	3.58e-05	100	79	5	PP_MEP_500_K3
CoexpressionAtlas	PP_HSC_top-relative-expression-ranked_500_k-means-cluster#1	PTPN6 P2RX1 SNX20 TESC DOK2	5.66e-05	110	79	5	PP_HSC_500_K1
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#3_top-relative-expression-ranked_100	GSTM1 GSTM2 TESC	7.25e-05	22	79	3	gudmap_developingGonad_e12.5_epididymis_k3_100
CoexpressionAtlas	DevelopingGonad_e16.5_testes_emap-8444_k-means-cluster#5_top-relative-expression-ranked_200	GSTM1 GSTM2 OSR2 TESC	8.40e-05	62	79	4	gudmap_developingGonad_e16.5_testes_200_k5
CoexpressionAtlas	PP_RBC_top-relative-expression-ranked_500_k-means-cluster#5	P2RX1 SNX20 TESC DOK2	1.14e-04	67	79	4	PP_RBC_500_K5
CoexpressionAtlas	DevelopingGonad_P2_testes_emap-30171_k-means-cluster#2_top-relative-expression-ranked_100	GSTM1 GSTM2 TESC	1.21e-04	26	79	3	gudmap_developingGonad_P2_testes_100_k2
CoexpressionAtlas	dev gonad_e12.5_M_InterstitTestis_Sma_k-means-cluster#1_top-relative-expression-ranked_500	GSTM1 GSTM2 TESC PCOLCE	1.51e-04	72	79	4	gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_k1_500
CoexpressionAtlas	PP_GMP_top-relative-expression-ranked_500_k-means-cluster#2	PTPN6 P2RX1 SNX20 TESC	1.59e-04	73	79	4	PP_GMP_500_K2
CoexpressionAtlas	PP_epoMEP_top-relative-expression-ranked_500_k-means-cluster#5	PTPN6 P2RX1 TESC DOK2	1.76e-04	75	79	4	PP_epoMEP_500_K5
CoexpressionAtlas	DevelopingGonad_e12.5_testes_emap-29069_k-means-cluster#2_top-relative-expression-ranked_200	GSTM1 GSTM2 TESC	1.87e-04	30	79	3	gudmap_developingGonad_e12.5_testes_k2_200
CoexpressionAtlas	DevelopingGonad_P2_testes_emap-30171_top-relative-expression-ranked_100	GSTM1 GSTM2 OSR2 TESC	2.26e-04	80	79	4	gudmap_developingGonad_P2_testes_100
CoexpressionAtlas	DevelopingGonad_e12.5_testes_emap-29069_k-means-cluster#1_top-relative-expression-ranked_500	GSTM1 GSTM2 OSR2 TESC	2.49e-04	82	79	4	gudmap_developingGonad_e12.5_testes_k1_500
CoexpressionAtlas	dev gonad_e12.5_M_InterstitTestis_Sma_k-means-cluster#1_top-relative-expression-ranked_1000	GSTM1 GSTM2 TTC39C TESC PCOLCE	2.83e-04	155	79	5	gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_k1_1000
CoexpressionAtlas	dev gonad_e11.5_M_GonMes_Sma_k-means-cluster#1_top-relative-expression-ranked_1000	GSTM1 GSTM2 TTC39C TESC PCOLCE	2.92e-04	156	79	5	gudmap_dev gonad_e11.5_M_GonMes_Sma_k1_1000
CoexpressionAtlas	DevelopingGonad_P2_testes_emap-30171_k-means-cluster#1_top-relative-expression-ranked_200	GSTM1 GSTM2 TESC	3.24e-04	36	79	3	gudmap_developingGonad_P2_testes_200_k1
CoexpressionAtlas	DevelopingGonad_P2_testes_emap-30171_top-relative-expression-ranked_200	GSTM1 GSTM2 OSR2 TESC FAF1	3.38e-04	161	79	5	gudmap_developingGonad_P2_testes_200
CoexpressionAtlas	DevelopingGonad_e16.5_testes_emap-8444_top-relative-expression-ranked_200	GSTM1 GSTM2 OSR2 TESC FAF1	3.57e-04	163	79	5	gudmap_developingGonad_e16.5_testes_200
CoexpressionAtlas	DevelopingGonad_e14.5_ testes_emap-6710_k-means-cluster#2_top-relative-expression-ranked_200	GSTM1 GSTM2 TESC	3.81e-04	38	79	3	gudmap_developingGonad_e14.5_ testes_200_k2
CoexpressionAtlas	DevelopingGonad_e18.5_testes_emap-11164_top-relative-expression-ranked_200	GSTM1 GSTM2 OSR2 TESC FAF1	3.89e-04	166	79	5	gudmap_developingGonad_e18.5_testes_200
CoexpressionAtlas	dev gonad_e13.5_M_SertoliCell_Sox9_top-relative-expression-ranked_200	GSTM1 GSTM2 TTC39C TESC PCOLCE	4.33e-04	170	79	5	gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_200
CoexpressionAtlas	DevelopingGonad_e18.5_testes_emap-11164_k-means-cluster#3_top-relative-expression-ranked_100	GSTM1 GSTM2 OSR2	4.77e-04	41	79	3	gudmap_developingGonad_e18.5_testes_100_k3
CoexpressionAtlas	DevelopingGonad_e14.5_ testes_emap-6710_k-means-cluster#5_top-relative-expression-ranked_500	GSTM1 GSTM2 OSR2 TESC	4.92e-04	98	79	4	gudmap_developingGonad_e14.5_ testes_500_k5
CoexpressionAtlas	dev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#1_top-relative-expression-ranked_500	GSTM1 GSTM2 TESC PCOLCE	4.92e-04	98	79	4	gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k1_500
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#1_top-relative-expression-ranked_200	GSTM1 GSTM2 TESC	5.13e-04	42	79	3	gudmap_developingGonad_e12.5_epididymis_k1_200
CoexpressionAtlas	dev gonad_e12.5_M_SertoliCell_Sox9_top-relative-expression-ranked_200	GSTM1 GSTM2 TTC39C TESC PCOLCE	5.21e-04	177	79	5	gudmap_dev gonad_e12.5_M_SertoliCell_Sox9_200
CoexpressionAtlas	dev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#4_top-relative-expression-ranked_1000	GSTM1 GSTM2 ATP2B1 PCOLCE	6.15e-04	104	79	4	gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k4_1000
CoexpressionAtlas	PP_epoMEP_top-relative-expression-ranked_1000_k-means-cluster#5	PTPN6 P2RX1 SNX20 TESC DOK2	6.36e-04	185	79	5	PP_epoMEP_1000_K5
CoexpressionAtlas	dev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#4_top-relative-expression-ranked_1000	GSTM1 GSTM2 TTC39C TESC PCOLCE	7.35e-04	191	79	5	gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k4_1000
CoexpressionAtlas	PP_GMP_top-relative-expression-ranked_1000_k-means-cluster#4	PTPN6 P2RX1 SNX20 TESC DOK2	8.07e-04	195	79	5	PP_GMP_1000_K4
CoexpressionAtlas	DevelopingGonad_P2_ovary_emap-30224_k-means-cluster#1_top-relative-expression-ranked_500	GSTM1 GSTM2 TESC	8.07e-04	49	79	3	gudmap_developingGonad_P2_ovary_500_k1
Computational	ROS metabolism.	GSTM1 GSTM2 GSTM4	1.29e-04	22	49	3	MODULE_310
Drug	Glutathione S-(2,4 Dinitrobenzene)	GSTM1 GSTM2	1.25e-05	2	81	2	DB02458
Drug	EUK-189	GSTM1 GSTM2 GSTM4	2.35e-05	16	81	3	ctd:C436526
Drug	C14791	GSTM1 GSTM2 GSTM4	3.41e-05	18	81	3	CID011954044
Drug	C14793	GSTM1 GSTM2 GSTM4	3.41e-05	18	81	3	CID011954046
Drug	C14803	GSTM1 GSTM2 GSTM4	3.41e-05	18	81	3	CID011954054
Drug	C14805	GSTM1 GSTM2 GSTM4	3.41e-05	18	81	3	CID011954056
Drug	C14804	GSTM1 GSTM2 GSTM4	3.41e-05	18	81	3	CID011954055
Drug	C14806	GSTM1 GSTM2 GSTM4	3.41e-05	18	81	3	CID011954057
Drug	C14848	GSTM1 GSTM2 GSTM4	3.41e-05	18	81	3	CID011954067
Drug	C14856	GSTM1 GSTM2 GSTM4	3.41e-05	18	81	3	CID011954069
Drug	C14855	GSTM1 GSTM2 GSTM4	3.41e-05	18	81	3	CID011954068
Drug	S-(2,2-dichloro-1-hydroxy)ethylglutathione	GSTM1 GSTM2 GSTM4	3.41e-05	18	81	3	CID011954070
Drug	AC1L4MYY	GSTM1 GSTM2 GSTM4	3.41e-05	18	81	3	CID000188517
Drug	Clch2cosg	GSTM1 GSTM2 GSTM4	3.41e-05	18	81	3	CID000163913
Drug	2-(S-glutathionyl) acetyl glutathione	GSTM1 GSTM2 GSTM4	4.73e-05	20	81	3	CID011954072
Drug	C14865	GSTM1 GSTM2 GSTM4	4.73e-05	20	81	3	CID011954073
Drug	NSC39143	GSTM1 GSTM2 GSTM4 APC	6.65e-05	61	81	4	CID000002579
Drug	Estrone [53-16-7]; Down 200; 14.8uM; PC3; HT_HG-U133A	SPRED2 SMG7 APC SPIDR SBNO2 PCOLCE	6.76e-05	194	81	6	6647_DN
Drug	Guanabenz acetate [23256-50-0]; Down 200; 13.8uM; PC3; HT_HG-U133A	DHRS12 FOXRED2 WNT10B APC TBX10 SPIDR	7.36e-05	197	81	6	4642_DN
Drug	4-chloronitrobenzene	GSTM1 GSTM2	7.47e-05	4	81	2	ctd:C010407
Drug	sulfolithocholic acid	GSTM1 GSTM2	7.47e-05	4	81	2	ctd:C014202
Drug	Oxantel pamoate [68813-55-8]; Up 200; 6.6uM; MCF7; HT_HG-U133A	DHRS12 ELOA2 SPRED2 AFDN GRIN1 SIPA1	8.00e-05	200	81	6	2632_UP
Drug	S-(formylmethyl)glutathione	GSTM1 GSTM2 GSTM4	8.32e-05	24	81	3	CID011954074
Drug	AC1NSK22	GSTM1 GSTM2 GSTM4 ZFYVE1	9.06e-05	66	81	4	CID005311131
Disease	Brugada syndrome (implicated_via_orthology)	GSTM1 GSTM2 GSTM4	2.06e-07	5	82	3	DOID:0050451 (implicated_via_orthology)
Disease	level of glutathione S-transferase mu 1 in blood serum	GSTM1 GSTM2	7.63e-06	2	82	2	OBA_2041806
Disease	Intellectual Disability	RNASEH2C APC GRIN1 ATIC FHIP2A MED13 DYNC1H1 DYNC1I2	3.49e-05	447	82	8	C3714756
Disease	gamma-glutamylglycine measurement	ACADM UHRF2	1.59e-04	7	82	2	EFO_0800670
Disease	Degenerative Diseases, Central Nervous System	GSTM1 GSTM2 GSTM4	1.76e-04	39	82	3	C0270715
Disease	Degenerative Diseases, Spinal Cord	GSTM1 GSTM2 GSTM4	1.76e-04	39	82	3	C0751733
Disease	Neurodegenerative Disorders	GSTM1 GSTM2 GSTM4	1.76e-04	39	82	3	C0524851
Disease	cholestasis (implicated_via_orthology)	GSTM1 PYGM	2.71e-04	9	82	2	DOID:13580 (implicated_via_orthology)
Disease	medulloblastoma (is_implicated_in)	GSTM1 APC	3.38e-04	10	82	2	DOID:0050902 (is_implicated_in)
Disease	kidney cancer (implicated_via_orthology)	LATS2 SAV1	4.13e-04	11	82	2	DOID:263 (implicated_via_orthology)
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	ATP2B1 MED13	1.01e-03	17	82	2	DOID:0060307 (is_implicated_in)
Disease	hippocampal tail volume	ENPP6 FAF1	1.27e-03	19	82	2	EFO_0009398
Disease	inflammatory bowel disease (is_implicated_in)	GSTM1 ANO6	1.27e-03	19	82	2	DOID:0050589 (is_implicated_in)
Disease	saturated fatty acids to total fatty acids percentage	GSTM1 GSTM2	1.55e-03	21	82	2	EFO_0022305
Disease	Arthrogryposis	SLC18A3 DYNC1H1	1.55e-03	21	82	2	C0003886
Disease	transitional cell carcinoma (is_implicated_in)	GSTM1 APC	1.70e-03	22	82	2	DOID:2671 (is_implicated_in)
Disease	cholangiocarcinoma (is_implicated_in)	GSTM1 APC	1.70e-03	22	82	2	DOID:4947 (is_implicated_in)
Disease	free cholesterol measurement, high density lipoprotein cholesterol measurement	GSTM1 GSTM2 CDH22 SLC12A3 TYW1B	1.87e-03	315	82	5	EFO_0004612, EFO_0008591

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALRQASDKDDRPFQG	AFDN	176	P55196
RPAEAGEFTRRAFAN	GTPBP3	136	Q969Y2
QLARKEAFARAGFFG	ABCB10	386	Q9NRK6
DIFDKFNFTGARVPR	CELSR1	2251	Q9NYQ6
KANRQREPGLGFSFE	ACADM	26	P11310
RAPEGAFRASFEDKL	BMS1	1076	Q14692
SANGEAKVFRPRDRD	ATP2B1	616	P20020
FNGAVSDDSRRLGKF	PCOLCE	221	Q15113
KRKFQPDGRSDESAA	PUM3	91	Q15397
KPDSLFFNDGQRRID	ANO6	56	Q4KMQ2
KFREEAAFPGRRVNA	ELOA2	496	Q8IYF1
NKADFQGISPERAFA	DAD1	81	P61803
VPFDAVARSLGKNFR	DOK2	301	O60496
SGKLFDRLRDENPDF	FAR1	61	Q8WVX9
RNGADDLKAHPFFSA	LATS2	961	Q9NRM7
RNPAELAEKSQARGF	ATXN1L	381	P0C7T5
AGAKLSLNRQFFDER	DYNC1I2	261	Q13409
KFLERAGDASAPRFN	FAM83B	876	Q5T0W9
FGNLRAKFLRPSDDE	CWF19L2	361	Q2TBE0
DAFPNLKDFISRFEG	GSTM2	176	P28161
RNFSGPDKDVFFDDR	FOXRED2	501	Q8IWF2
KDRPRFDFANLAVAA	OSR2	111	Q8N2R0
KFDAEFRRFALPRAS	PARD6A	21	Q9NPB6
RPNGFVDNSFLDIKR	MAML2	191	Q8IZL2
AAFRPNSKPDGANLR	ADAMTS3	1116	O15072
RLPLRDEAKGAFFQF	GAS2L2	471	Q8NHY3
RFRKDDGTFPLDNEV	DEPTOR	116	Q8TB45
AAAQPSGRFFQDRKP	DHRS12	271	A0PJE2
AREFRKLGFSNSNPA	ELMO3	341	Q96BJ8
EENSAKFPVGRRDFD	PMCHL1	56	Q16048
EENSAKFPIGRRDFD	PMCHL2	56	Q9BQD1
DDAFRKNLESALRFG	DYNC1H1	3616	Q14204
DPRFADLGTFRDQAI	CDH22	366	Q9UJ99
PSGEFLERRFLASNK	FAF1	581	Q9UNN5
EDASAFPGKRALISF	FHIP2A	346	Q5W0V3
GPDFKSNFRAAPIRS	ENPP6	371	Q6UWR7
DRFLNPNGSRKVDFF	CYP8B1	406	Q9UNU6
EEKNLSPGFNFRFAR	P2RX1	281	P51575
AVAKPFSAAARARAN	SLC18A3	261	Q16572
DRCKAFNTRRVDPGF	TMEM178B	41	H3BS89
PEAARSGDAAANKLF	PLEKHN1	41	Q494U1
HPDGNRFFSGARKDA	WRAP53	376	Q9BUR4
FSDRTAAPGNPFRAK	SYNJ1	1406	O43426
APGGRLSKDFCAREF	NDUFAF8	41	A1L188
DAFPNLKDFISRFEG	GSTM4	176	Q03013
DAFPNLKDFISRFEG	GSTM1	176	P09488
LKIDRNPFAKGFRDS	TBX15	291	Q96SF7
ALRPSFRNLDFSKGH	SMG7	426	Q92540
AAATKPAAFEDAGRL	SKIDA1	491	Q1XH10
DFLRAANPVDFLSKA	FTSJ3	256	Q8IY81
PFAANADFRAFLLAK	SIPA1	496	Q96FS4
NESGDQLKRPFGAFR	SNCAIP	851	Q9Y6H5
DKLFQLSRPFAGFED	SBNO2	146	Q9Y2G9
PENEALLNGAKSFFR	MED13	1376	Q9UHV7
KRFRGQERPDDFTAS	AKAP3	266	O75969
KLPNNEDRVRGSFAF	APC	1826	P25054
DPAFKRNGFRINLAK	CILP2	851	Q8IUL8
FFDNRNLRKGPSGLA	TESC	66	Q96BS2
DSFPDRFRGAELKEV	CNGA3	96	Q16281
ARKDFSSRLAAGPTF	CDK5RAP1	51	Q96SZ6
DRPAEAFAAGERALQ	SNX20	241	Q7Z614
IASNPFAKGFRESDL	TBX10	241	O75333
SDNFFDGQRKRPLGD	SAV1	136	Q9H4B6
LSFADGKFLRRNDPE	UHRF2	316	Q96PU4
KEERGRGNFPDRFSA	TRBV5-5	71	A0A597
FLNRVAAAFPGDVDR	PYGM	411	P11217
APHSLFFKDALRDQG	SPIDR	716	Q14159
QLGDLFSKAGDFPRA	TONSL	316	Q96HA7
SFPRFGARAKEVAEA	PRX	361	Q9BXM0
PLERDFDRFIGATAN	RNASEH2C	111	Q8TDP1
APFRLNDGFKDEATV	SLC12A3	916	P55017
RKFGLTFQSPADARA	SPRED2	96	Q7Z698
RQALGFAKEARESPD	TMEM44	321	Q2T9K0
FFPFRDNVDRAKRSG	ATIC	541	P31939
SFLARPSRKNQGDFS	PTPN6	26	P29350
QDRFRKLGRFPEAFS	ZFYVE1	341	Q9HBF4
GEKFSRDFLDSREAP	WNT10B	206	O00744
VVRPFFALDGSDNKA	TTC39C	281	Q8N584
RAAGKLDQPDRFSFK	GTF3C1	1531	Q12789
DIKAAFAPFGRISDA	TIA1	121	P31483
LFGANERSFDPKDTR	TYW1B	641	Q6NUM6
DRFSPFGRFKVNSEE	GRIN1	581	Q05586