Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionalpha-glucosidase activity

MGAM AGL

5.53e-057332GO:0090599
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

KMT2A KMT2B

7.37e-058332GO:0140945
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

KMT2A KMT2B

1.18e-0410332GO:0140999
GeneOntologyMolecularFunctionunmethylated CpG binding

KMT2A KMT2B

1.18e-0410332GO:0045322
GeneOntologyMolecularFunctionglucosidase activity

MGAM AGL

2.74e-0415332GO:0015926
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

KMT2A KMT2B

4.94e-0420332GO:0042800
GeneOntologyMolecularFunctioncomplement binding

APCS C3AR1

1.27e-0332332GO:0001848
GeneOntologyMolecularFunctionhydrolase activity, acting on glycosyl bonds

MGAM SMPD1 AGL

1.71e-03144333GO:0016798
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

KMT2A KMT2B

2.40e-0344332GO:0140938
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

KMT2A KMT2B

5.64e-0368332GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

KMT2A KMT2B

5.80e-0369332GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

KMT2A KMT2B

6.13e-0371332GO:0042054
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

DENND5B DENND4A DENND5A

6.46e-03231333GO:0005085
MousePhenoenlarged liver

KMT2A SMPD1 CHST2 KMT2B WDR11 AGL

8.93e-06253286MP:0000599
DomainuDENN

DENND5B DENND4A DENND5A

1.98e-0614343SM00800
DomainuDENN

DENND5B DENND4A DENND5A

2.47e-0615343PF03456
DomainDENN

DENND5B DENND4A DENND5A

3.04e-0616343PF02141
DomainUDENN

DENND5B DENND4A DENND5A

3.04e-0616343PS50946
DomainDDENN

DENND5B DENND4A DENND5A

3.04e-0616343PS50947
DomaindDENN_dom

DENND5B DENND4A DENND5A

3.04e-0616343IPR005112
DomainuDENN_dom

DENND5B DENND4A DENND5A

3.04e-0616343IPR005113
DomaindDENN

DENND5B DENND4A DENND5A

3.04e-0616343PF03455
DomainDENN

DENND5B DENND4A DENND5A

3.04e-0616343SM00799
DomainDENN

DENND5B DENND4A DENND5A

3.04e-0616343PS50211
DomainDENN_dom

DENND5B DENND4A DENND5A

3.04e-0616343IPR001194
DomaindDENN

DENND5B DENND4A DENND5A

3.04e-0616343SM00801
DomainMeTrfase_trithorax

KMT2A KMT2B

3.22e-062342IPR016569
DomainFYrich_C

KMT2A KMT2B

3.21e-055342IPR003889
DomainFYrich_N

KMT2A KMT2B

3.21e-055342IPR003888
DomainFYRC

KMT2A KMT2B

3.21e-055342SM00542
DomainFYRN

KMT2A KMT2B

3.21e-055342SM00541
DomainFYRN

KMT2A KMT2B

3.21e-055342PF05964
DomainFYRC

KMT2A KMT2B

3.21e-055342PF05965
DomainFYRC

KMT2A KMT2B

3.21e-055342PS51543
DomainFYRN

KMT2A KMT2B

3.21e-055342PS51542
Domainzf-CXXC

KMT2A KMT2B

1.75e-0411342PF02008
DomainZnf_CXXC

KMT2A KMT2B

1.75e-0411342IPR002857
DomainZF_CXXC

KMT2A KMT2B

1.75e-0411342PS51058
DomainPost-SET_dom

KMT2A KMT2B

3.80e-0416342IPR003616
DomainPostSET

KMT2A KMT2B

3.80e-0416342SM00508
DomainPOST_SET

KMT2A KMT2B

3.80e-0416342PS50868
DomainRUN

DENND5B DENND5A

4.83e-0418342SM00593
DomainRUN

DENND5B DENND5A

5.39e-0419342PS50826
DomainRun_dom

DENND5B DENND5A

5.39e-0419342IPR004012
DomainRUN

DENND5B DENND5A

5.39e-0419342PF02759
DomainPLAT

DENND5B DENND5A

6.61e-0421342PF01477
DomainPLAT

DENND5B DENND5A

6.61e-0421342PS50095
DomainPLAT/LH2_dom

DENND5B DENND5A

6.61e-0421342IPR001024
Domain-

DENND5B DENND5A

6.61e-04213422.60.60.20
DomainEPHD

KMT2A KMT2B

7.26e-0422342PS51805
DomainAT_hook

KMT2A KMT2B

1.10e-0327342SM00384
DomainAT_hook_DNA-bd_motif

KMT2A KMT2B

1.10e-0327342IPR017956
DomainSET

KMT2A KMT2B

2.52e-0341342PF00856
DomainSET

KMT2A KMT2B

3.17e-0346342SM00317
DomainSET_dom

KMT2A KMT2B

3.73e-0350342IPR001214
DomainSET

KMT2A KMT2B

3.73e-0350342PS50280
DomainGlycoside_hydrolase_SF

MGAM AGL

4.18e-0353342IPR017853
DomainConA-like_dom

APCS ADGRV1 NBEAL2

7.28e-03219343IPR013320
DomainPHD

KMT2A KMT2B

8.21e-0375342PF00628
Pubmed

KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions.

KMT2A KMT2B

1.04e-06236228723559
Pubmed

KRT13, FAIM2 and CYP2W1 mRNA expression in oral squamous cell carcinoma patients with risk habits.

FAIM2 CYP2W1

3.12e-06336225735388
Pubmed

WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket.

KMT2A KMT2B

6.24e-06436218840606
Pubmed

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes.

KMT2A KMT2B

6.24e-06436226267306
Pubmed

MLL1 is required for PAX7 expression and satellite cell self-renewal in mice.

KMT2A KMT2B

6.24e-06436231534153
Pubmed

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

KMT2A KMT2B

6.24e-06436223129768
Pubmed

Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation.

KMT2A KMT2B

6.24e-06436217166833
Pubmed

Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory.

KMT2A KMT2B

6.24e-06436225834037
Pubmed

Oncogenic All1 fusion proteins target Drosha-mediated microRNA processing.

KMT2A DROSHA

6.24e-06436217581865
Pubmed

Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA.

KMT2A KMT2B

6.24e-06436234156981
Pubmed

Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.

DENND5B DENND4A DENND5A

7.72e-063736320937701
Pubmed

Evolving Catalytic Properties of the MLL Family SET Domain.

KMT2A KMT2B

1.04e-05536226320581
Pubmed

Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.

KMT2A KMT2B

1.04e-05536225561738
Pubmed

MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

KMT2A KMT2B

1.04e-05536228609655
Pubmed

MLL associates specifically with a subset of transcriptionally active target genes.

KMT2A KMT2B

1.56e-05636216199523
Pubmed

Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.

KMT2A KMT2B

1.56e-05636224176642
Pubmed

Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.

KMT2A KMT2B

2.91e-05836223130995
Pubmed

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

KMT2A KMT2B

2.91e-05836222266653
Pubmed

Analysis of BCL6-interacting proteins by tandem mass spectrometry.

KMT2B DROSHA PARP12

3.69e-056236316147992
Pubmed

Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

KMT2A KMT2B

3.73e-05936222665483
Pubmed

Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.

KMT2A KMT2B

3.73e-05936216951254
Pubmed

DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.

KMT2A KMT2B

4.66e-051036229276034
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

KMT2A DENND4A DENND5A WDR11 DROSHA PARP12

5.03e-0565036638777146
Pubmed

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.

KMT2A KMT2B

6.83e-051236227563068
Pubmed

Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.

KMT2A KMT2B

8.07e-051336224619213
Pubmed

SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.

KMT2A KMT2B

1.24e-041636223870121
Pubmed

Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation.

DENND5B DENND5A

1.58e-041836232496646
Pubmed

Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.

MAEL ABCA13

1.76e-041936225367360
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KMT2A KMT2B

2.16e-042136227626377
Pubmed

Structural basis for activity regulation of MLL family methyltransferases.

KMT2A KMT2B

2.38e-042236226886794
Pubmed

Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription.

KMT2A KMT2B

3.08e-042536225664857
Pubmed

Rebalancing gene haploinsufficiency in vivo by targeting chromatin.

KMT2A KMT2B

3.87e-042836227256596
Pubmed

Impact of WIN site inhibitor on the WDR5 interactome.

KMT2A KMT2B

9.16e-044336233472061
Pubmed

Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.

KMT2A KMT2B

9.59e-044436224183668
Cytoband5p13.3

DROSHA PDZD2

1.63e-04243625p13.3
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

DENND5B DENND4A DENND5A

6.68e-0625273504
GeneFamilyZinc fingers CXXC-type

KMT2A KMT2B

1.40e-0412272136
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2A KMT2B

1.17e-0334272487
GeneFamilyPHD finger proteins

KMT2A KMT2B

7.93e-039027288
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CLDN22 ADGRV1 ABCA13 PDZD2

1.35e-051813649d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CLDN22 ADGRV1 ABCA13 PDZD2

1.38e-05182364eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCellLPS_only-Hematopoietic_Myeloid-Granulocytic_cells-Neutrophils|LPS_only / Treatment groups by lineage, cell group, cell type

MGAM C3AR1 DENND5A NBEAL2

2.00e-052003643504aeba7b30cac9c428ba3871c072e2202752b4
ToppCellLPS_only-Hematopoietic_Myeloid-Granulocytic_cells|LPS_only / Treatment groups by lineage, cell group, cell type

MGAM C3AR1 DENND5A NBEAL2

2.00e-05200364c5afebbc16024c60e84a67be81c78b0bfb73ec68
Diseaseprogression free survival, ovarian serous carcinoma

MGAM ABCA13

3.11e-0422352EFO_0004920, EFO_1001516
Diseaseciliopathy (implicated_via_orthology)

WDR11 CC2D2B

1.04e-0340352DOID:0060340 (implicated_via_orthology)
Diseaseocular hypertension, response to triamcinolone acetonide

TMEM132C DENND5A

1.55e-0349352EFO_0006954, EFO_1001069
Diseaseforced expiratory volume

CACNA1D POFUT1 WDR11 DROSHA AGL

2.25e-03789355EFO_0004314
Diseasecongenital heart disease (implicated_via_orthology)

KMT2A KMT2B

3.05e-0369352DOID:1682 (implicated_via_orthology)
DiseaseManic

CACNA1D DNAH8

3.88e-0378352C0338831
Diseaseleptin measurement

DNAH8 PDZD2

4.18e-0381352EFO_0005000

Protein segments in the cluster

PeptideGeneStartEntry
ANIPGAIPHWQLLYR

SMPD1

526

P17405
LSILALHWYPQQING

ADGRV1

5746

Q8WXG9
PRIPIWAAANYANAH

RTL10

11

Q7L3V2
LFNVYPWLGALLQLH

CYP2W1

216

Q8TAV3
PSYLNHLNNLILWQH

ABCA13

4406

Q86UQ4
IHPYPNNILSVWVYL

CC2D2B

1416

Q6DHV5
PFSLAHLALQGQWPY

C3AR1

76

Q16581
KLHQDPGQPLYILWN

DENND4A

1726

Q7Z401
PGQPLYILWNAHTQK

DENND4A

1731

Q7Z401
LAILLPFQYVPWLHA

FAIM2

241

Q9BWQ8
LQNLYRFIHPNPGNW

MAEL

196

Q96JY0
HYNLNVWVAPVFPLR

HMCN2

2161

Q8NDA2
YILPWQEPALNTHLS

MGAM

2611

O43451
DNAVLHLPLLYQWLQ

PDZD2

6

O15018
HLPLLYQWLQNSLQE

PDZD2

11

O15018
LINHPPWNLKLVQLY

DNAH8

2101

Q96JB1
VLPPSLDHVYAQWRQ

KMT2B

1531

Q9UMN6
QNDPWLLPEICQHYN

PARP12

146

Q9H0J9
LTNYLPHWKNLNLDL

CLDN22

26

Q8N7P3
DPLQYIHLNLQPYWA

FBXL4

316

Q9UKA2
QWQHVYVPILPASLL

DENND5B

321

Q6ZUT9
QWQHVYVPILPASLL

DENND5A

336

Q6IQ26
NAVLPPSLDHNYAQW

KMT2A

1791

Q03164
LLHPNAYVRNGWNLL

CACNA1D

186

Q01668
ANPLKTLWNHSLQPY

NRROS

66

Q86YC3
LNRTLAVPPWIEYQH

POFUT1

61

Q9H488
EVWLNYPLHPLQLQE

DROSHA

1076

Q9NRR4
PNYLLSPNWQFDITH

TMEM132C

596

Q8N3T6
LWAPYHAVNLLQAVA

LTB4R2

236

Q9NPC1
PPHTQVRNQVYSWLL

NBEAL2

2026

Q6ZNJ1
LQTALQPPDWLQGHY

CHST2

406

Q9Y4C5
PLPANILDWQALNYE

APCS

196

P02743
HQLYLWVDNIPLSRP

SPEF1

11

Q9Y4P9
FLFHAINKPNAPIWL

TTC17

606

Q96AE7
LWQLLAQYHQAPLAP

UTS2R

276

Q9UKP6
LLLAIHPPNYIVLWN

WDR11

131

Q9BZH6
HQNPWGQLINLFYIP

TRAV22

56

A0A0B4J277
YNLVNSPHLKPAWVL

AGL

236

P35573