Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

3.05e-1526287GO:0005248
GeneOntologyMolecularFunctionsodium channel activity

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

6.06e-1352287GO:0005272
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

ATP12A SLC29A1 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.20e-12171289GO:0015081
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

ANO4 CACNA1E ANO5 ATP12A KCNA10 SLC29A1 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

6.79e-127582813GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

ANO4 CACNA1E ANO5 ATP12A KCNA10 SLC29A1 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.20e-117932813GO:0015075
GeneOntologyMolecularFunctionmonoatomic ion channel activity

ANO4 CACNA1E ANO5 KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.27e-114592811GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1E ATP12A KCNA10 SLC29A1 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.46e-114652811GO:0046873
GeneOntologyMolecularFunctionchannel activity

ANO4 CACNA1E ANO5 KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

5.36e-115252811GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

ANO4 CACNA1E ANO5 KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

5.47e-115262811GO:0022803
GeneOntologyMolecularFunctiontransmembrane transporter activity

ANO4 CACNA1E ANO5 ATP12A KCNA10 ABCA7 SLC29A1 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.08e-1011802814GO:0022857
GeneOntologyMolecularFunctiontransporter activity

ANO4 CACNA1E ANO5 ATP12A KCNA10 ABCA7 SLC29A1 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

3.47e-1012892814GO:0005215
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1E ATP12A KCNA10 SLC29A1 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

3.54e-106272811GO:0022890
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1E KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

6.08e-10343289GO:0005261
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1E ATP12A KCNA10 SLC29A1 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

6.50e-106642811GO:0008324
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN2A SCN3A SCN8A

3.07e-0914284GO:0031402
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN2A SCN3A SCN8A

4.53e-0826284GO:0031420
GeneOntologyMolecularFunctiongated channel activity

ANO4 CACNA1E ANO5 KCNA10 SCN1A SCN2A SCN7A

3.01e-07334287GO:0022836
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ANO4 ANO5 ABCA7

4.92e-0551283GO:0140303
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1E KCNA10 SCN1A SCN2A

1.15e-04182284GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1E KCNA10 SCN1A SCN2A

1.20e-04184284GO:0022832
GeneOntologyMolecularFunctionphospholipid transporter activity

ANO4 ANO5 ABCA7

1.50e-0474283GO:0005548
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

SCN1A SCN2A

2.55e-0417282GO:0099508
GeneOntologyMolecularFunctionintracellularly calcium-gated chloride channel activity

ANO4 ANO5

3.55e-0420282GO:0005229
GeneOntologyMolecularFunctionintracellularly calcium-gated channel activity

ANO4 ANO5

3.55e-0420282GO:0141147
GeneOntologyMolecularFunctionphospholipid scramblase activity

ANO4 ANO5

4.71e-0423282GO:0017128
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

ANO4 ANO5

2.23e-0350282GO:0099095
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

ANO4 ANO5 KCNA10

2.44e-03193283GO:0015276
GeneOntologyMolecularFunctionlipid transporter activity

ANO4 ANO5 ABCA7

2.55e-03196283GO:0005319
GeneOntologyMolecularFunctionligand-gated channel activity

ANO4 ANO5 KCNA10

2.58e-03197283GO:0022834
GeneOntologyMolecularFunctioncalmodulin binding

SCN2A SCN3A SCN5A

4.00e-03230283GO:0005516
GeneOntologyMolecularFunctionchloride channel activity

ANO4 ANO5

6.44e-0386282GO:0005254
GeneOntologyMolecularFunctionmonoatomic anion channel activity

ANO4 ANO5

9.13e-03103282GO:0005253
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ATP12A ABCA7

1.02e-02109282GO:0042626
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

ANO4 ANO5

1.32e-02125282GO:0015108
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

ANO4 ANO5

1.89e-02151282GO:0008509
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1E KCNA10

1.91e-02152282GO:0022843
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.76e-1262287GO:0086002
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A

6.68e-1236286GO:0086010
GeneOntologyBiologicalProcesscardiac muscle cell action potential

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

2.05e-1187287GO:0086001
GeneOntologyBiologicalProcesscardiac muscle cell contraction

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

3.30e-1193287GO:0086003
GeneOntologyBiologicalProcesstransmission of nerve impulse

CACNA1E SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A

1.24e-10112287GO:0019226
GeneOntologyBiologicalProcessaction potential

KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.86e-10201288GO:0001508
GeneOntologyBiologicalProcessneuronal action potential

SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A

2.27e-1063286GO:0019228
GeneOntologyBiologicalProcesssodium ion transmembrane transport

ATP12A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

2.44e-10208288GO:0035725
GeneOntologyBiologicalProcessactin-mediated cell contraction

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

3.02e-10127287GO:0070252
GeneOntologyBiologicalProcessactin filament-based movement

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.12e-09153287GO:0030048
GeneOntologyBiologicalProcesscardiac muscle contraction

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

2.06e-09167287GO:0060048
GeneOntologyBiologicalProcesssodium ion transport

ATP12A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

2.23e-09275288GO:0006814
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

ANO4 CACNA1E ANO5 ATP12A KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

2.83e-0910172812GO:0098660
GeneOntologyBiologicalProcessheart contraction

CACNA1E SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

4.18e-09298288GO:0060047
GeneOntologyBiologicalProcessheart process

CACNA1E SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

5.55e-09309288GO:0003015
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

ANO4 CACNA1E ANO5 ATP12A KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

7.98e-0911152812GO:0034220
GeneOntologyBiologicalProcessmembrane depolarization

SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A

1.22e-08121286GO:0051899
GeneOntologyBiologicalProcessstriated muscle contraction

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.27e-08217287GO:0006941
GeneOntologyBiologicalProcessregulation of membrane potential

KCNA10 SLC29A1 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

3.23e-08559289GO:0042391
GeneOntologyBiologicalProcessmonoatomic ion transport

ANO4 CACNA1E ANO5 ATP12A KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

8.14e-0813742812GO:0006811
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

CACNA1E ATP12A KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.91e-079222810GO:0098662
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

CACNA1E ATP12A KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

2.33e-079422810GO:0098655
GeneOntologyBiologicalProcesscirculatory system process

CACNA1E SLC29A1 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

3.24e-07733289GO:0003013
GeneOntologyBiologicalProcessmetal ion transport

CACNA1E ATP12A KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

4.05e-0710002810GO:0030001
GeneOntologyBiologicalProcessmuscle contraction

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

8.15e-07400287GO:0006936
GeneOntologyBiologicalProcessmonoatomic cation transport

CACNA1E ATP12A KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.54e-0611572810GO:0006812
GeneOntologyBiologicalProcessblood circulation

CACNA1E SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.62e-06648288GO:0008015
GeneOntologyBiologicalProcessmuscle system process

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

6.48e-06547287GO:0003012
GeneOntologyBiologicalProcessactin filament-based process

HMCN1 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

2.00e-05912288GO:0030029
GeneOntologyBiologicalProcessplasma membrane organization

ANO4 ANO5 ABCA7 A4GALT

1.15e-04188284GO:0007009
GeneOntologyBiologicalProcessnerve development

SCN1A SCN2A SCN8A

4.27e-04109283GO:0021675
GeneOntologyBiologicalProcessintracellular sodium ion homeostasis

ATP12A SCN7A

7.55e-0430282GO:0006883
GeneOntologyBiologicalProcessbehavioral response to pain

CACNA1E SCN3A

8.60e-0432282GO:0048266
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

CACNA1E ATP12A SCN5A

9.23e-04142283GO:0098659
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

CACNA1E ATP12A SCN5A

9.23e-04142283GO:0099587
GeneOntologyBiologicalProcessbehavior

CACNA1E ABCA7 SCN1A SCN2A SCN3A SCN8A

1.06e-03891286GO:0007610
GeneOntologyBiologicalProcesscellular response to hypoxia

SLC29A1 SCN2A DDR2

1.52e-03169283GO:0071456
GeneOntologyBiologicalProcesscellular response to decreased oxygen levels

SLC29A1 SCN2A DDR2

1.77e-03178283GO:0036294
GeneOntologyBiologicalProcessresponse to abiotic stimulus

CACNA1E ABCA7 SLC29A1 SCN1A SCN2A DDR2 SCN7A

1.86e-031361287GO:0009628
GeneOntologyBiologicalProcessadult walking behavior

SCN1A SCN8A

2.09e-0350282GO:0007628
GeneOntologyBiologicalProcessresponse to pain

CACNA1E SCN3A

2.17e-0351282GO:0048265
GeneOntologyBiologicalProcesssodium ion homeostasis

ATP12A SCN7A

2.17e-0351282GO:0055078
GeneOntologyBiologicalProcesscellular response to oxygen levels

SLC29A1 SCN2A DDR2

2.29e-03195283GO:0071453
GeneOntologyBiologicalProcessretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

NBAS ERGIC2

2.35e-0353282GO:0006890
GeneOntologyBiologicalProcessdetermination of adult lifespan

SCN1A SCN2A

2.43e-0354282GO:0008340
GeneOntologyBiologicalProcessphospholipid translocation

ANO4 ABCA7

2.52e-0355282GO:0045332
GeneOntologyBiologicalProcesswalking behavior

SCN1A SCN8A

3.00e-0360282GO:0090659
GeneOntologyBiologicalProcesslipid translocation

ANO4 ABCA7

3.00e-0360282GO:0034204
GeneOntologyBiologicalProcessregulation of membrane lipid distribution

ANO4 ABCA7

3.51e-0365282GO:0097035
GeneOntologyBiologicalProcessimport across plasma membrane

CACNA1E ATP12A SCN5A

3.65e-03230283GO:0098739
GeneOntologyBiologicalProcesscellular response to osmotic stress

SCN2A SCN7A

4.28e-0372282GO:0071470
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

6.60e-1717287GO:0001518
GeneOntologyCellularComponentsodium channel complex

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

5.24e-1529287GO:0034706
GeneOntologyCellularComponentcation channel complex

CACNA1E KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.41e-11235289GO:0034703
GeneOntologyCellularComponenttransporter complex

CACNA1E ERGIC2 ATP12A KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

5.42e-115502811GO:1990351
GeneOntologyCellularComponenttransmembrane transporter complex

CACNA1E ATP12A KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

7.72e-105232810GO:1902495
GeneOntologyCellularComponentmonoatomic ion channel complex

CACNA1E KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

9.59e-10378289GO:0034702
GeneOntologyCellularComponentplasma membrane protein complex

CACNA1E ATP12A KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

3.74e-087852810GO:0098797
GeneOntologyCellularComponentnode of Ranvier

SCN1A SCN2A SCN8A

2.42e-0620283GO:0033268
GeneOntologyCellularComponentaxon initial segment

SCN1A SCN2A SCN8A

7.68e-0629283GO:0043194
GeneOntologyCellularComponentmembrane protein complex

CACNA1E ATP12A KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.37e-0514982810GO:0098796
GeneOntologyCellularComponentintercalated disc

SCN1A SCN2A SCN5A

1.02e-0468283GO:0014704
GeneOntologyCellularComponentT-tubule

SCN1A SCN2A SCN5A

1.59e-0479283GO:0030315
GeneOntologyCellularComponentmain axon

SCN1A SCN2A SCN8A

2.26e-0489283GO:0044304
GeneOntologyCellularComponentcell-cell contact zone

SCN1A SCN2A SCN5A

2.66e-0494283GO:0044291
GeneOntologyCellularComponentpresynaptic membrane

CACNA1E SCN1A SCN2A SCN8A

4.81e-04277284GO:0042734
GeneOntologyCellularComponentaxon

SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A

9.92e-04891286GO:0030424
GeneOntologyCellularComponentZ disc

SCN1A SCN5A SCN8A

1.06e-03151283GO:0030018
GeneOntologyCellularComponentI band

SCN1A SCN5A SCN8A

1.39e-03166283GO:0031674
GeneOntologyCellularComponentglial cell projection

ABCA7 SCN7A

1.80e-0347282GO:0097386
GeneOntologyCellularComponentsarcolemma

SCN1A SCN2A SCN5A

2.05e-03190283GO:0042383
GeneOntologyCellularComponentapical plasma membrane

ATP12A ABCA7 SLC29A1 DDR2

3.82e-03487284GO:0016324
GeneOntologyCellularComponentsarcomere

SCN1A SCN5A SCN8A

4.39e-03249283GO:0030017
GeneOntologyCellularComponentmyofibril

SCN1A SCN5A SCN8A

5.67e-03273283GO:0030016
GeneOntologyCellularComponentpresynapse

CACNA1E SLC29A1 SCN1A SCN2A SCN8A

5.90e-03886285GO:0098793
GeneOntologyCellularComponentcontractile muscle fiber

SCN1A SCN5A SCN8A

6.70e-03290283GO:0043292
GeneOntologyCellularComponentsynaptic membrane

CACNA1E SCN1A SCN2A SCN8A

7.20e-03583284GO:0097060
GeneOntologyCellularComponentcell-cell junction

HMCN1 SCN1A SCN2A SCN5A

7.55e-03591284GO:0005911
GeneOntologyCellularComponentapical part of cell

ATP12A ABCA7 SLC29A1 DDR2

7.60e-03592284GO:0045177
GeneOntologyCellularComponentanchoring junction

HMCN1 SCN1A SCN2A DDR2 SCN5A

8.81e-03976285GO:0070161
HumanPhenoSimple febrile seizure

SCN1A SCN2A SCN3A SCN8A

4.33e-0727134HP:0011171
HumanPhenoFocal automatism seizure

SCN1A SCN2A SCN8A

2.82e-0612133HP:0032898
HumanPhenoEpileptic encephalopathy

CACNA1E SCN1A SCN2A SCN3A SCN8A

7.09e-06119135HP:0200134
HumanPhenoComplex febrile seizure

SCN1A SCN2A SCN8A

7.14e-0616133HP:0011172
HumanPhenoFocal hemiclonic seizure

SCN1A SCN2A SCN8A

2.89e-0525133HP:0006813
HumanPhenoClonic seizure

SCN1A SCN2A SCN3A SCN8A

3.80e-0581134HP:0020221
HumanPhenoFocal head nodding automatism seizure

SCN2A SCN8A

5.99e-055132HP:0032906
HumanPhenoNeonatal electro-clinical non-motor seizure

SCN2A SCN8A

5.99e-055132HP:0032812
HumanPhenoNeonatal seizure with electrographic correlate

SCN2A SCN8A

5.99e-055132HP:0032808
HumanPhenoNeonatal electro-clinical seizure

SCN2A SCN8A

5.99e-055132HP:0032809
HumanPhenoNeonatal electro-clinical seizure with behavior arrest

SCN2A SCN8A

5.99e-055132HP:0032823
HumanPhenoHypsarrhythmia

CACNA1E SCN1A SCN2A SCN3A SCN8A

6.08e-05185135HP:0002521
HumanPhenoGeneralized clonic seizure

SCN1A SCN2A SCN8A

7.43e-0534133HP:0011169
HumanPhenoAbnormal ankle morphology

ANO5 SCN1A SCN2A DDR2

8.73e-05100134HP:0034673
HumanPhenoEncephalopathy

CACNA1E NBAS SCN1A SCN2A SCN3A SCN8A

8.94e-05335136HP:0001298
HumanPhenoNormal interictal EEG

SCN2A SCN8A

8.97e-056132HP:0002372
HumanPhenoStatus epilepticus

CACNA1E SCN1A SCN2A SCN3A SCN8A

1.04e-04207135HP:0002133
HumanPhenoHyperkinetic movements

CACNA1E SCN1A SCN2A

1.22e-0440133HP:0002487
HumanPhenoFocal non-motor seizure

SCN1A SCN2A SCN8A

1.22e-0440133HP:0032679
HumanPhenoEyelid myoclonia seizure

SCN2A SCN8A

1.25e-047132HP:0032678
HumanPhenoFocal clonic seizure

SCN1A SCN2A SCN8A

1.41e-0442133HP:0002266
HumanPhenoMyoclonus

CACNA1E ABCA7 SCN1A SCN2A SCN3A SCN8A

1.58e-04371136HP:0001336
HumanPhenoCyanosis

SCN1A SCN2A SCN4A SCN8A

1.61e-04117134HP:0000961
HumanPhenoPhotosensitive myoclonic seizure

SCN1A SCN2A

1.67e-048132HP:0001327
HumanPhenoCyanotic episode

SCN1A SCN2A

1.67e-048132HP:0200048
HumanPhenoAbnormal hippocampus morphology

ABCA7 SCN1A SCN2A

2.10e-0448133HP:0025100
HumanPhenoFocal impaired awareness seizure

SCN1A SCN2A SCN3A SCN8A

2.15e-04126134HP:0002384
HumanPhenoAbnormal morphology of the limbic system

ABCA7 SCN1A SCN2A

2.24e-0449133HP:0007343
HumanPhenoAbnormality of vision

CACNA1E NBAS HMCN1 ABCA7 SCN1A SCN2A SCN3A DDR2 SCN4A SCN8A

2.45e-0413731310HP:0000504
HumanPhenoBilateral tonic-clonic seizure with focal onset

SCN1A SCN2A SCN8A

2.67e-0452133HP:0007334
HumanPhenoApneic episodes in infancy

SCN4A SCN5A

2.67e-0410132HP:0005949
HumanPhenoSudden unexpected death in epilepsy

SCN1A SCN8A

2.67e-0410132HP:0033258
HumanPhenoLimited neck range of motion

SCN1A SCN2A

3.26e-0411132HP:0000466
HumanPhenoNeonatal seizure

SCN2A SCN8A

3.26e-0411132HP:0032807
HumanPhenoPes valgus

SCN1A SCN2A SCN4A

3.33e-0456133HP:0008081
HumanPhenoEEG with generalized epileptiform discharges

CACNA1E SCN1A SCN2A SCN3A SCN8A

3.65e-04270135HP:0011198
HumanPhenoInfection-related seizure

SCN1A SCN2A SCN3A SCN8A

3.69e-04145134HP:0032892
HumanPhenoSeizure precipitated by febrile infection

SCN1A SCN2A SCN3A SCN8A

3.69e-04145134HP:0032894
HumanPhenoFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SCN2A SCN3A SCN8A

3.69e-04145134HP:0002373
HumanPhenoEpilepsia partialis continua

SCN1A SCN2A

3.91e-0412132HP:0012847
HumanPhenoImpulsivity

SCN1A SCN2A SCN3A SCN8A

4.09e-04149134HP:0100710
HumanPhenoGeneralized cerebral atrophy/hypoplasia

SCN1A SCN2A

4.62e-0413132HP:0007058
HumanPhenoGeneralized tonic seizure

SCN1A SCN2A SCN8A

4.95e-0464133HP:0010818
HumanPhenoVisual impairment

CACNA1E NBAS HMCN1 SCN1A SCN2A SCN3A DDR2 SCN4A SCN8A

5.11e-041174139HP:0000505
HumanPhenoMultifocal epileptiform discharges

SCN1A SCN2A SCN8A

5.42e-0466133HP:0010841
HumanPhenoAortopulmonary collateral arteries

SCN1A SCN2A

6.20e-0415132HP:0031834
HumanPhenoPhotosensitive tonic-clonic seizure

SCN1A SCN2A

6.20e-0415132HP:0007207
HumanPhenoFacial tics

SCN1A SCN2A

6.20e-0415132HP:0011468
HumanPhenoDysgenesis of the hippocampus

SCN1A SCN2A

7.07e-0416132HP:0025101
HumanPhenoCerebral palsy

CACNA1E SCN2A SCN3A SCN4A

7.55e-04175134HP:0100021
HumanPhenoInterictal epileptiform activity

CACNA1E SCN1A SCN2A SCN3A SCN8A

7.91e-04319135HP:0011182
HumanPhenoAtypical absence status epilepticus

SCN1A SCN2A

8.00e-0417132HP:0011151
HumanPhenoFocal motor status epilepticus

SCN1A SCN2A

8.00e-0417132HP:0032663
HumanPhenoFocal emotional seizure with laughing

SCN1A SCN2A

8.00e-0417132HP:0010821
HumanPhenoInterictal EEG abnormality

CACNA1E SCN1A SCN2A SCN3A SCN8A

8.61e-04325135HP:0025373
HumanPhenoVisually-induced seizure

SCN1A SCN2A

8.99e-0418132HP:0020216
HumanPhenoGeneralized non-convulsive status epilepticus without coma

SCN1A SCN2A

8.99e-0418132HP:0032860
HumanPhenoFocal emotional seizure

SCN1A SCN2A

8.99e-0418132HP:0025613
HumanPhenoHypokalemia

SERPINA6 SCN4A SCN5A

9.18e-0479133HP:0002900
HumanPhenoIncreased muscle fatiguability

SERPINA6 SCN4A

1.00e-0319132HP:0003750
HumanPhenoAbnormality of the ankle

ANO5 SCN1A SCN2A DDR2

1.07e-03192134HP:0003028
HumanPhenoNon-convulsive status epilepticus without coma

SCN1A SCN2A

1.11e-0320132HP:0032671
HumanPhenoPsychomotor deterioration

SCN2A SCN8A

1.11e-0320132HP:0002361
HumanPhenoAbnormal knee physiology

ANO5 SCN1A SCN2A

1.22e-0387133HP:0034670
HumanPhenoTalipes valgus

SCN1A SCN2A

1.23e-0321132HP:0004684
HumanPhenoEEG with spike-wave complexes

SCN1A SCN2A SCN8A

1.26e-0388133HP:0010850
HumanPhenoEEG with abnormally slow frequencies

SCN1A SCN3A SCN8A

1.26e-0388133HP:0011203
HumanPhenoFocal sensory seizure

SCN1A SCN8A

1.35e-0322132HP:0011157
HumanPhenoReflex seizure

SCN1A SCN2A

1.35e-0322132HP:0020207
HumanPhenoFocal tonic seizure

SCN2A SCN8A

1.48e-0323132HP:0011167
HumanPhenoReduced systolic function

SCN4A SCN5A

1.48e-0323132HP:0006673
HumanPhenoTibial torsion

SCN1A SCN2A

1.48e-0323132HP:0100694
HumanPhenoRigidity

SCN1A SCN2A SCN3A SCN8A

1.61e-03214134HP:0002063
HumanPhenoElbow flexion contracture

ANO5 DDR2 SCN4A

1.67e-0397133HP:0002987
HumanPhenoIntellectual disability, borderline

SCN3A SCN8A

1.75e-0325132HP:0006889
HumanPhenoEpileptic aura

SCN1A SCN8A

1.75e-0325132HP:0033348
HumanPhenoMalignant hyperthermia

SCN4A SCN5A

1.89e-0326132HP:0002047
HumanPhenoPsychomotor regression

ABCA7 SCN1A SCN2A SCN3A SCN8A

1.97e-03390135HP:0002489
HumanPhenoMental deterioration

ABCA7 SCN1A SCN2A SCN3A SCN8A

1.97e-03390135HP:0001268
HumanPhenoLimited knee extension

SCN1A SCN2A

2.04e-0327132HP:0003066
HumanPhenoStatus epilepticus without prominent motor symptoms

SCN1A SCN2A

2.04e-0327132HP:0031475
HumanPhenoAphasia

ABCA7 SCN1A SCN5A

2.04e-03104133HP:0002381
HumanPhenoFocal aware seizure

SCN1A SCN2A

2.19e-0328132HP:0002349
HumanPhenoElbow contracture

ANO5 DDR2 SCN4A

2.33e-03109133HP:0034391
HumanPhenoStatus epilepticus with prominent motor symptoms

SCN1A SCN2A

2.35e-0329132HP:0032658
HumanPhenoLimb myoclonus

SCN2A SCN8A

2.35e-0329132HP:0045084
HumanPhenoProgressive gait ataxia

SCN1A SCN2A

2.51e-0330132HP:0007240
HumanPhenoProgressive ataxia

SCN1A SCN2A

2.51e-0330132HP:0001329
MousePhenoventricular fibrillation

SCN1A SCN5A

5.90e-057242MP:0006110
MousePhenohyperostosis

ANO5 SLC29A1

5.90e-057242MP:0030222
MousePhenoabnormal action potential

SCN1A SCN2A SCN5A SCN8A

7.18e-05133244MP:0005402
MousePhenoabnormal muscle relaxation

DDR2 SCN4A SCN8A

1.50e-0461243MP:0004036
MousePhenoabnormal behavioral response to xenobiotic

SERPINA6 SLC29A1 SCN1A A4GALT SCN8A

1.54e-04309245MP:0009745
MousePhenofibrillation

SCN1A SCN5A

2.54e-0414242MP:0006109
MousePhenoincreased muscle fatigability

ANO5 SCN4A

3.34e-0416242MP:0003646
MousePhenoimpaired behavioral response to xenobiotic

SERPINA6 SLC29A1 A4GALT

3.73e-0483243MP:0009747
MousePhenoabnormal muscle fiber morphology

ANO5 DDR2 SCN4A SCN5A SCN8A

5.43e-04406245MP:0004087
MousePhenomuscular atrophy

HAT1 SCN4A SCN8A

5.72e-0496243MP:0002269
MousePhenoakinesia

SCN1A SCN4A

5.82e-0421242MP:0002690
DomainNa_channel_asu

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

6.76e-1910277IPR001696
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

6.76e-1910277IPR010526
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

6.76e-1910277PF06512
DomainChannel_four-helix_dom

CACNA1E KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

5.32e-1757279IPR027359
Domain-

CACNA1E KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

5.32e-17572791.20.120.350
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN5A SCN8A

2.56e-146275PF11933
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN5A SCN8A

2.56e-146275IPR024583
DomainIon_trans_dom

CACNA1E KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

3.65e-14114279IPR005821
DomainIon_trans

CACNA1E KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

3.65e-14114279PF00520
DomainIQ

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.83e-1181277SM00015
DomainIQ_motif_EF-hand-BS

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

3.91e-1190277IPR000048
DomainIQ

SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A

3.52e-0993276PS50096
DomainIQ

SCN1A SCN3A SCN4A SCN8A

3.15e-0671274PF00612
DomainAnoct_dimer

ANO4 ANO5

4.21e-057272PF16178
DomainAnoct_dimer

ANO4 ANO5

4.21e-057272IPR032394
DomainAnoctamin

ANO4 ANO5

8.99e-0510272PF04547
DomainAnoctamin

ANO4 ANO5

8.99e-0510272IPR007632
DomainEF-hand-dom_pair

SCN1A SCN3A SCN7A SCN8A

7.25e-04287274IPR011992
DomainMFS_dom

MFSD13A SLC29A1

1.59e-02134272IPR020846
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

2.87e-1431237M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

3.67e-1432237M27455
PathwayREACTOME_L1CAM_INTERACTIONS

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

6.30e-10121237M872
PathwayREACTOME_CARDIAC_CONDUCTION

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.05e-09130237M27454
PathwayREACTOME_MUSCLE_CONTRACTION

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

2.33e-08203237M5485
PathwayWP_DRAVET_SYNDROME

SCN1A SCN2A SCN3A SCN8A

1.07e-0728234M45519
PathwayWP_ADHD_AND_AUTISM_ASD_PATHWAYS

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

1.31e-06367237M48346
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

2.51e-05575237M29853
PathwayWP_RETT_SYNDROME

SCN1A SCN2A SCN8A

6.25e-0548233M39759
PathwayREACTOME_INDUCTION_OF_CELL_CELL_FUSION

ANO4 ANO5

1.96e-0413232M46426
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

SCN2A SCN3A

2.63e-0347232M42524
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ANO4 ANO5 ATP12A

2.82e-03176233MM15718
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ANO4 ANO5 ATP12A

3.15e-03183233M997
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

ANO4 ANO5 ATP12A ABCA7 SLC29A1

4.22e-03681235MM14985
PathwayREACTOME_LATE_SARS_COV_2_INFECTION_EVENTS

ANO4 ANO5

5.75e-0370232M46438
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

ANO4 ANO5 ATP12A ABCA7 SLC29A1

5.87e-03736235M27287
PathwayWP_DRAVET_SYNDROME_SCN1AA1783V_POINT_MUTATION_MODEL

SCN1A SCN3A

6.24e-0373232MM16641
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

6.25e-031432237M509
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A

1.29e-17928615746173
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A

1.29e-17928616382098
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN3A SCN4A SCN5A SCN8A

2.32e-16528517724025
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN2A SCN3A SCN5A SCN8A

1.83e-131228530175250
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN2A SCN3A SCN5A SCN8A

2.97e-131328515123669
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN2A SCN3A SCN8A

3.36e-13428417537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN2A SCN3A SCN8A

3.36e-13428435031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN2A SCN3A SCN8A

3.36e-13428429578003
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN2A SCN3A SCN8A

5.03e-12628423652591
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA1E SCN1A SCN3A SCN4A SCN5A SCN7A SCN8A

1.54e-1113928716985003
Pubmed

Confirmation of quantitative trait loci for alcohol preference in mice.

SCN1A SCN2A SCN3A SCN7A

4.56e-10152849726281
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN1A SCN2A SCN3A

4.67e-10328312610651
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN1A SCN2A SCN8A

4.67e-10328317928448
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN1A SCN2A SCN3A

4.67e-10328323859570
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN1A SCN2A SCN3A

4.67e-10328314973256
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN1A SCN2A SCN3A

4.67e-10328318784617
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN1A SCN2A SCN3A

4.67e-10328317544618
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN1A SCN2A SCN8A

4.67e-10328332845893
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN1A SCN2A SCN8A

4.67e-10328328518218
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN1A SCN2A SCN8A

1.87e-09428321156207
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN1A SCN2A SCN3A

1.87e-09428335801810
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

SCN1A SCN2A SCN3A

1.87e-0942838974318
Pubmed

Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.

SCN1A SCN2A SCN3A

4.67e-0952831679748
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN1A SCN2A SCN3A

4.67e-0952838812438
Pubmed

Early development of electrical excitability in the mouse enteric nervous system.

SCN3A SCN5A SCN8A

4.67e-09528322875929
Pubmed

Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.

SCN1A SCN2A SCN3A

4.67e-09528324337656
Pubmed

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.

SCN1A SCN5A SCN8A

1.63e-08728315272007
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

SCN1A SCN2A SCN8A

1.63e-08728325818041
Pubmed

Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins.

SCN1A SCN4A SCN5A

2.61e-0882839412493
Pubmed

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.

SCN1A SCN5A SCN8A

3.91e-08928317884088
Pubmed

Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.

SCN1A SCN2A SCN3A

1.02e-07122838169823
Pubmed

Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine.

SCN1A SCN5A

6.25e-07228216054936
Pubmed

Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.

SCN1A SCN2A

6.25e-07228229649454
Pubmed

Sodium channel expression within chronic multiple sclerosis plaques.

SCN2A SCN8A

6.25e-07228217805013
Pubmed

Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.

SCN2A SCN3A

6.25e-07228220346423
Pubmed

Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies.

SCN1A SCN5A

6.25e-07228233712547
Pubmed

Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.

SCN1A SCN2A

6.25e-07228226311622
Pubmed

Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.

SCN1A SCN8A

6.25e-07228237901435
Pubmed

Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.

SCN1A SCN8A

6.25e-07228233411788
Pubmed

An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.

SCN1A SCN8A

6.25e-07228226410685
Pubmed

Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.

SCN1A SCN8A

6.25e-07228231943325
Pubmed

Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants.

SCN4A SCN5A

6.25e-07228211834499
Pubmed

Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.

SCN1A SCN2A

6.25e-07228210827969
Pubmed

Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.

SCN1A SCN2A

6.25e-07228215249644
Pubmed

Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.

SCN1A SCN3A

6.25e-07228227690330
Pubmed

Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.

SCN1A SCN2A

6.25e-07228219694741
Pubmed

Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.

SCN2A SCN8A

6.25e-07228235348308
Pubmed

Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.

SCN2A SCN3A

6.25e-07228211245985
Pubmed

Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.

SCN2A SCN8A

6.25e-07228215760941
Pubmed

The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.

SCN1A SCN2A

6.25e-07228221377452
Pubmed

Differential expression of two sodium channel subtypes in human brain.

SCN1A SCN2A

6.25e-0722821317301
Pubmed

Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.

SCN2A SCN8A

6.25e-07228218601978
Pubmed

Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.

SCN1A SCN3A

6.25e-07228223965409
Pubmed

Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.

SCN2A SCN3A

6.25e-07228223016767
Pubmed

Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.

SCN2A SCN3A

6.25e-07228227153334
Pubmed

Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.

SCN1A SCN2A

6.25e-07228233096315
Pubmed

FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.

SCN2A SCN8A

6.25e-07228219465131
Pubmed

Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.

SCN1A SCN3A

6.25e-07228224990319
Pubmed

Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif.

SCN4A SCN5A

6.25e-07228230944319
Pubmed

Isoform-specific effects of the beta2 subunit on voltage-gated sodium channel gating.

SCN2A SCN5A

6.25e-07228216847056
Pubmed

Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.

SCN1A SCN2A

6.25e-07228231439038
Pubmed

Direct amplification of a single dissected chromosomal segment by polymerase chain reaction: a human brain sodium channel gene is on chromosome 2q22-q23.

SCN2A SCN7A

6.25e-0722821846440
Pubmed

Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.

SCN1A SCN8A

6.25e-07228237665666
Pubmed

The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.

SCN1A SCN8A

6.25e-07228217881658
Pubmed

SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.

SCN1A SCN2A

6.25e-07228230693367
Pubmed

Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.

SCN2A SCN8A

6.25e-07228223735284
Pubmed

Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.

SCN1A SCN8A

1.87e-06328224704313
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN3A

1.87e-06328219284629
Pubmed

Gene-to-gene interaction between sodium channel-related genes in determining the risk of antiepileptic drug resistance.

SCN1A SCN2A

1.87e-06328219270815
Pubmed

Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.

SCN1A SCN2A

1.87e-06328228784306
Pubmed

Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.

SCN2A SCN3A

1.87e-06328216052353
Pubmed

Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.

SCN1A SCN2A

1.87e-06328232185219
Pubmed

Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort.

SCN1A SCN2A

1.87e-06328232005694
Pubmed

Calmodulin mediates Ca2+ sensitivity of sodium channels.

SCN2A SCN5A

1.87e-06328215316014
Pubmed

Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy.

SCN1A SCN2A

1.87e-06328225155934
Pubmed

The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.

SCN1A SCN8A

1.87e-06328228117367
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN1A SCN3A

1.87e-06328233895391
Pubmed

Modulation of skeletal and cardiac voltage-gated sodium channels by calmodulin.

SCN4A SCN5A

1.87e-06328215746172
Pubmed

Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of NaV1.2 and NaV1.6.

SCN2A SCN8A

1.87e-06328238514708
Pubmed

Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction.

SCN1A SCN8A

1.87e-06328226182346
Pubmed

Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.

SCN2A SCN8A

1.87e-06328216033895
Pubmed

Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons.

SCN2A SCN8A

1.87e-06328229991598
Pubmed

De novo SCN1A, SCN8A, and CLCN2 mutations in childhood absence epilepsy.

SCN1A SCN8A

1.87e-06328231054517
Pubmed

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.

SCN4A SCN5A

1.87e-06328220038812
Pubmed

GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.

SCN1A SCN3A

1.87e-06328227816501
Pubmed

Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.

SCN1A SCN2A

3.75e-06428226637798
Pubmed

Models for discovery of targeted therapy in genetic epileptic encephalopathies.

SCN1A SCN8A

3.75e-06428228742937
Pubmed

Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.

SCN3A SCN5A

6.24e-06528215548568
Pubmed

Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression.

SCN2A SCN8A

6.24e-06528224077057
Pubmed

Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.

SCN2A SCN5A

6.24e-06528225232683
Pubmed

Identification and characterization of TMEM16E and TMEM16F genes in silico.

ANO4 ANO5

9.36e-06628215067359
Pubmed

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.

SCN3A SCN8A

9.36e-06628223711479
Pubmed

Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?

SCN2A SCN8A

9.36e-06628217513486
Pubmed

ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.

ANO4 ANO5

1.31e-05728222075693
Pubmed

Anoctamins are a family of Ca2+-activated Cl- channels.

ANO4 ANO5

1.74e-05828222946059
Pubmed

Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996.

SCN1A SCN2A SCN3A

2.57e-05712838751373
Pubmed

Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.

ANO4 ANO5

2.80e-051028219015192
Pubmed

Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.

ANO4 ANO5

2.80e-051028223532839
Pubmed

Common variants associated with general and MMR vaccine-related febrile seizures.

SCN1A SCN2A

2.80e-051028225344690
Pubmed

Structure and function of TMEM16 proteins (anoctamins).

ANO4 ANO5

2.80e-051028224692353
InteractionSCN4B interactions

SCN1A SCN2A SCN8A

1.34e-078283int:SCN4B
InteractionSCN11A interactions

SCN1A SCN5A SCN8A

1.08e-0615283int:SCN11A
InteractionSCN8A interactions

SCN4A SCN5A SCN8A

2.70e-0620283int:SCN8A
InteractionS1PR4 interactions

ERGIC2 ATP12A SLC29A1 TM9SF3

3.69e-05137284int:S1PR4
InteractionSCN5A interactions

SCN1A SCN5A SCN8A

3.74e-0547283int:SCN5A
InteractionIL2RA interactions

ERGIC2 ATP12A TM9SF3

5.68e-0554283int:IL2RA
InteractionNEDD4L interactions

SCN1A SCN2A SCN3A SCN5A SCN8A

7.12e-05320285int:NEDD4L
InteractionSCN10A interactions

SCN1A SCN5A

1.02e-0411282int:SCN10A
InteractionMLNR interactions

NBAS ERGIC2 ATP12A

1.13e-0468283int:MLNR
InteractionNALCN interactions

SCN1A SCN5A

1.68e-0414282int:NALCN
InteractionSPPL2B interactions

ERGIC2 ATP12A SCN4A TM9SF3

2.87e-04233284int:SPPL2B
InteractionSCN4A interactions

SLC29A1 SCN4A SCN8A

3.34e-0498283int:SCN4A
InteractionTM2D2 interactions

ERGIC2 SLC29A1

3.85e-0421282int:TM2D2
InteractionSCN9A interactions

SCN1A SCN5A

3.85e-0421282int:SCN9A
InteractionSNTA1 interactions

SCN1A SCN4A SCN5A

4.10e-04105283int:SNTA1
InteractionSLC22A15 interactions

ERGIC2 ATP12A

4.23e-0422282int:SLC22A15
InteractionS1PR1 interactions

ERGIC2 ATP12A TM9SF3

4.95e-04112283int:S1PR1
InteractionP2RY2 interactions

ATP12A SLC29A1 TM9SF3

4.95e-04112283int:P2RY2
InteractionB3GNT7 interactions

ERGIC2 ATP12A

5.04e-0424282int:B3GNT7
InteractionCACNA1D interactions

SCN1A SCN5A

5.04e-0424282int:CACNA1D
InteractionSCN1A interactions

SCN1A SCN5A

7.38e-0429282int:SCN1A
InteractionTMC4 interactions

ANO5 ABCA7

7.90e-0430282int:TMC4
InteractionNEDD4 interactions

SCN1A SCN2A SCN3A SCN5A SCN8A

8.27e-04544285int:NEDD4
CytobandEnsembl 112 genes in cytogenetic band chr2q24

SCN1A SCN2A SCN3A SCN7A

1.09e-06127284chr2q24
Cytoband2q24.3

SCN1A SCN2A

4.28e-05162822q24.3
CytobandEnsembl 112 genes in cytogenetic band chr1q25

CACNA1E HMCN1 TEDDM1

1.45e-04167283chr1q25
Cytoband1q25.3

CACNA1E TEDDM1

1.65e-04312821q25.3
CytobandEnsembl 112 genes in cytogenetic band chr11p15

ANO5 ZNF214 GVINP1

4.81e-03564283chr11p15
CytobandEnsembl 112 genes in cytogenetic band chr10q24

MFSD13A TM9SF3

5.94e-03189282chr10q24
Cytoband11p15.4

ZNF214 GVINP1

6.63e-0320028211p15.4
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A

1.29e-1692261203
GeneFamilyAnoctamins

ANO4 ANO5

6.32e-0510222865
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HNBGABA

CACNA1E ANO5 SCN1A SCN2A SCN3A SCN7A SCN8A

7.02e-06703287M39070
CoexpressionAtlasdev lower uro neuro_e15.5_PelvicGanglion_Sox10_k-means-cluster#2_top-relative-expression-ranked_1000

CACNA1E NBAS HMCN1 SCN2A SCN7A

9.69e-0891275gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k2_1000
CoexpressionAtlasdev lower uro neuro_e15.5_PelvicGanglion_Sox10_k-means-cluster#4_top-relative-expression-ranked_500

CACNA1E NBAS HMCN1 SCN2A

2.03e-0741274gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k4_500
CoexpressionAtlasdev lower uro neuro_e15.5_PelvicGanglion_Sox10_top-relative-expression-ranked_500

CACNA1E NBAS HMCN1 SCN2A SCN3A DDR2

5.93e-06371276gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_500
CoexpressionAtlasdev lower uro neuro_e15.5_PelvicGanglion_Sox10_top-relative-expression-ranked_1000

CACNA1E NBAS HMCN1 SCN2A SCN3A DDR2 SCN7A

2.78e-05734277gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_1000
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_top-relative-expression-ranked_1000

ANO4 HMCN1 SCN1A SCN2A SCN3A DDR2 SCN7A

5.59e-05819277gudmap_developingKidney_e15.5_Peripheral blastema_1000
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_top-relative-expression-ranked_200

ANO4 SCN3A DDR2 SCN7A

6.75e-05175274gudmap_developingKidney_e15.5_Peripheral blastema_200
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#2_top-relative-expression-ranked_500

SCN1A SCN3A DDR2 SCN7A

1.27e-04206274gudmap_developingKidney_e15.5_Peripheral blastema_500_k2
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_top-relative-expression-ranked_500

ANO4 SCN1A SCN3A DDR2 SCN7A

1.68e-04421275gudmap_developingKidney_e15.5_Peripheral blastema_500
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#2_top-relative-expression-ranked_1000

HMCN1 SCN1A SCN3A SCN7A

2.07e-04234274gudmap_developingKidney_e15.5_Peripheral blastema_1000_k2
CoexpressionAtlasdev lower uro neuro_e14.5_BladdPelvicGanglion_Sox10_k-means-cluster#4_top-relative-expression-ranked_1000

CACNA1E SCN2A

2.92e-0420272gudmap_dev lower uro neuro_e14.5_BladdPelvicGanglion_Sox10_k4_1000
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#2_top-relative-expression-ranked_200

SCN3A DDR2 SCN7A

4.22e-04116273gudmap_developingKidney_e15.5_Peripheral blastema_200_k2
CoexpressionAtlasdev lower uro neuro_e15.5_PelvicGanglion_Sox10_k-means-cluster#1_top-relative-expression-ranked_500

NBAS SCN2A SCN3A

5.25e-04125273gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k1_500
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SERPINA6 SCN1A SCN2A SCN7A

3.68e-08151285f41c6558a5874b6464c157027fdf202257c60e5b
ToppCellE16.5-Endothelial-Endothelial_lymphatic|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1E HMCN1 SCN3A SCN5A

3.50e-06167284b93103a868fba63a8910bffb690a6242b9252833
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1E HMCN1 SCN3A SCN5A

3.50e-0616728426cd8ee5e826e71eaf58d10a906543a6932fb3f9
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1E HMCN1 SCN3A SCN5A

3.50e-06167284fcd583b1efd0ac883379982ea8e6c54f2c0be268
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1E HMCN1 SCN3A SCN5A

3.50e-06167284f6bc63138b7239211fa5f27a8dc799b6e022c0f8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SCN2A SCN3A SCN7A

4.21e-06175284787ac1a12cda10af5c8830471702a4cbaf43e79e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SCN2A SCN3A SCN7A

4.60e-06179284666072c0e8448dbaec1683d18368ec2502453f90
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

ANO5 SCN2A SCN3A SCN8A

4.92e-0618228457bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SCN2A SCN3A SCN7A

4.92e-061822845f513bbb7125956eb528e3120de3fd776770a7c3
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 SCN1A DDR2 SCN7A

5.24e-06185284785c55d39909fac74415f24427979691e7e694e6
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 SCN1A DDR2 SCN7A

5.24e-0618528497a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 SCN1A DDR2 SCN7A

5.36e-0618628494d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E SCN1A SCN2A SCN8A

5.36e-061862847278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ANO5 SCN2A SCN3A SCN8A

5.36e-06186284b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SCN2A SCN3A SCN7A

5.47e-06187284f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ANO5 SCN2A SCN3A SCN8A

5.59e-06188284c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SCN2A SCN3A SCN7A

5.71e-061892847eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SCN2A SCN3A SCN7A

5.71e-06189284e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SCN2A SCN3A SCN7A

5.71e-06189284975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell11.5-Airway-Epithelial-Epithelial|Airway / Age, Tissue, Lineage and Cell class

CACNA1E SCN2A SCN3A SCN5A

6.07e-06192284a77d3692ff02ef7e066a9bd9e22725055a25c4d4
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E SCN1A SCN2A SCN8A

6.20e-06193284be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E SCN1A SCN2A SCN8A

6.20e-061932840c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E SCN1A SCN2A SCN8A

6.20e-061932848689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A SCN2A SCN3A SCN8A

6.86e-06198284c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ANO4 SCN2A SCN3A SCN8A

6.86e-061982848f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ANO4 SCN2A SCN3A SCN8A

6.86e-06198284e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A SCN2A SCN3A SCN8A

6.86e-061982846d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A SCN2A SCN3A SCN8A

6.86e-061982844ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-2|TCGA-Cervix / Sample_Type by Project: Shred V9

CACNA1E SCN1A SCN5A

5.63e-05119283d21877baa088440a1e1902bbeb667b977475437a
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Acinar_Adenocarcinoma-7|TCGA-Lung / Sample_Type by Project: Shred V9

ANO4 HMCN1 SCN7A

7.32e-051302830219d0d5d21df08f816569c7eb34f1bfa095d29a
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SCN2A SCN7A

8.56e-0513728385b3a98039c1f68addad0334aa5b2584f6045aaa
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP12A SCN2A SCN7A

9.72e-05143283990844ca674d30b2924c74b45bed4fdfb8463fa7
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANO4 SCN5A SCN7A

9.92e-051442830322fef818a963be00535d5f141f028d43de5c6a
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANO4 SCN5A SCN7A

1.01e-0414528378f5f4b96420c7f391e4d32a9ed151ed95fad90b
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP12A SERPINA6 SCN1A

1.01e-0414528396712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANO4 SCN5A SCN7A

1.01e-04145283590ba937c741ae67460f303eca88b1cd3ac87f64
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_AB-8|TCGA-Thymus / Sample_Type by Project: Shred V9

HMCN1 SCN1A SCN7A

1.14e-041512835906562efd36fbcb91f96e0a0d3a8fe999ba1e79
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo1_Itga4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANO4 SCN5A SCN7A

1.23e-04155283cba6f3f7742b4d5d54ad0a0ac0dd4016e73fe658
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SCN1A SCN2A SCN3A

1.23e-0415528377fdae85d36efb776db977eb424b32487ef222e4
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANO4 SCN5A SCN7A

1.26e-04156283896e2d958be0a5c62fb6eebad2dfb7e1ce69f3ad
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SCN2A SCN7A

1.26e-041562834d2679e7639758c49fc25a2deb9109b08f0a3e57
ToppCellIPF-Epithelial-PNEC|IPF / Disease state, Lineage and Cell class

ANO4 SCN2A SCN3A

1.33e-04159283adec82df944fe8699a69ca52534353bef100f2f9
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ANO5 SCN2A SCN3A

1.33e-041592837747cef94c55144fddcd024a7495318357f1351b
ToppCellIPF-Epithelial-PNEC|World / Disease state, Lineage and Cell class

ANO4 SCN2A SCN3A

1.38e-04161283133833729ba8b6d3eef326590ca7476b17602cbb
ToppCellPND07-Endothelial-Endothelial_lymphatic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A SCN5A

1.38e-04161283133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A SCN5A

1.38e-04161283cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A SCN5A

1.38e-041612839466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP12A SCN2A SCN3A

1.41e-04162283285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A SCN5A

1.41e-0416228396c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP12A SCN2A SCN3A

1.46e-041642836fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A SCN5A

1.48e-04165283347b59aa625a8a960828b8620824d8ac48990e07
ToppCellPND03-Endothelial-Endothelial_lymphatic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A SCN5A

1.48e-041652831890f9c33b0c5b381d57f97042da2610a093a6de
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A SCN5A

1.48e-04165283507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A SCN5A

1.48e-0416528339a25be081a5d59c7cf107a997d352793d5025fb
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SCN2A SCN3A SCN7A

1.59e-041692830332f539a2f7d6dcd081a5d2f567290721f5a329
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SCN2A AGAP1

1.71e-041732834bc6d93716f093b460c8b047199db8cab5fea720
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

HMCN1 DDR2 SCN7A

1.79e-04176283510f9a14dc1c151d24d079e0cc004cdf4f86336c
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

ANO4 DDR2 SCN7A

1.79e-041762832e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

ANO4 DDR2 SCN7A

1.79e-04176283f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCellwk_15-18-Epithelial-PNS-Schwann_precursor|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SCN1A SCN5A SCN8A

1.82e-041772835357359e6c2161a37f39a6b3b78449f5cbc327d1
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SCN2A SCN7A

1.82e-04177283c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCellCOPD-Epithelial-PNEC|Epithelial / Disease state, Lineage and Cell class

ANO4 ANO5 SCN3A

1.89e-04179283988d0853c391da1e5004f73f3678047418d3f6d3
ToppCellPCW_13-14-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SCN1A SCN2A SCN3A

1.89e-04179283af0b54c9ea0b6e4210f22dbb6e88ecd3276a5f86
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANO4 SERPINA6 SCN7A

1.89e-04179283d1365d48d1b017a7917f4f63a82ac4720c3d87df
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP12A SCN2A SCN3A

2.01e-04183283d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SCN2A SCN7A

2.01e-041832832f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCellControl-Epithelial_cells-Airway_mucous|Control / group, cell type (main and fine annotations)

SCN2A SCN3A AGAP1

2.01e-0418328315d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SCN2A SCN3A

2.01e-041832832e831a4d99c6f983793df71c0994124c943c6da9
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO5 HMCN1 SCN2A

2.04e-04184283ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO5 HMCN1 SCN2A

2.04e-041842832cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO5 HMCN1 SCN2A

2.04e-041842832b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A SCN2A SCN8A

2.04e-041842837d9bcdaff8cbea4c50ab7db0f8e01f6bbd0ef593
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HMCN1 DDR2 SCN7A

2.11e-041862835473283fb95cee556b1f6934cf72169b676b5bcc
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SCN2A SCN3A

2.14e-0418728377886f99c229610abd28c4c370d2c7d1536c9782
ToppCellwk_08-11-Hematologic-Meg-ery-Cycling_definitive_erythroblast|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ABCA7 SLC29A1 A4GALT

2.14e-04187283c0965293f08d3e49000871777a5b26d81a4af203
ToppCellmetastatic_Lymph_Node-Fibroblasts-COL13A1+_matrix_FBs|metastatic_Lymph_Node / Location, Cell class and cell subclass

HMCN1 DDR2 SCN5A

2.14e-04187283e04fb35f2f5b120659d06b5ae427ab1ec56d5c36
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A SCN2A SCN8A

2.14e-041872837b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

ANO4 HMCN1 SCN7A

2.14e-04187283bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SCN2A SCN3A

2.18e-04188283eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)|Striatum / BrainAtlas - Mouse McCarroll V32

CACNA1E SCN2A SCN3A

2.18e-04188283e34ea7014c5a059a7db38f78bd903cf02616ddd3
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CACNA1E SCN2A SCN3A

2.18e-04188283b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HMCN1 SCN2A SCN3A

2.18e-04188283bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCellCOVID-19-kidney-DCT|kidney / Disease (COVID-19 only), tissue and cell type

HMCN1 SCN2A SCN3A

2.18e-04188283df1fd0819d301679f3c9ea404e942e39095912eb
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP12A SCN2A SCN3A

2.21e-041892833a295c215b5c18e7c673f92b7af5be523421682c
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A SCN2A SCN8A

2.21e-04189283f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCelldroplet-Limb_Muscle-nan-24m-Mesenchymal-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC29A1 DDR2 SCN7A

2.21e-041892836e52cac679e0541ca5f2be316bdabdbc34da6e18
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HMCN1 DDR2 SCN7A

2.25e-04190283d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

HMCN1 DDR2 SCN7A

2.25e-041902833a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCellFibroblasts-CD55+_Fibroblasts|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

ANO5 ABCA7 SLC29A1

2.25e-04190283b4088128f5acf53f43244c9af9fe44e033f1a57a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANO4 SCN5A SCN7A

2.28e-04191283764c3a8829ae1253a0790744138266e81fc075ec
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HMCN1 DDR2 SCN7A

2.28e-041912830fae1c2ef9f83ac7721d0a9d69455bf97eed9257
ToppCellASK440-Mesenchymal-Fibroblast|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

HMCN1 DDR2 SCN7A

2.28e-04191283387296b5377ef6839f0812e5b3529a10b5f7d530
ToppCellfacs-Heart-LV-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN3A DDR2 A4GALT

2.28e-04191283b7a57691a4742070cee640e285c1f4d0da95baf1
ToppCellfacs-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E SCN3A SCN5A

2.28e-0419128348823a97c38263f2c6e58348214f5b62773a6368
ToppCellASK440-Mesenchymal|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

HMCN1 DDR2 SCN7A

2.28e-04191283f12959eebb4167e1aa03de05d7711a702c58b3c9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP12A SCN2A SCN3A

2.28e-0419128396b78b4e819ea6052334bfcbc7abbf35897df885
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E SCN3A SCN5A

2.28e-041912830eedc66e967b1837ce2c14f8c14b3c1eba868c76
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 DDR2 SCN7A

2.32e-04192283d2c03490c5e835d0f0a732803093c64b8d4b4029
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDR2 A4GALT SCN7A

2.32e-04192283671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDR2 A4GALT SCN7A

2.32e-04192283840a34c1b82d218be999ab5e1bcafd6370d7a4b1
DrugZonisamide

SCN1A SCN2A SCN3A SCN4A SCN5A

1.18e-1117285DB00909
DrugAPETx1, Anthopleura elegantissima

SCN2A SCN3A SCN4A SCN8A

2.74e-116284ctd:C475726
Druglamotrigine

CACNA1E SCN2A SCN3A SCN4A SCN5A SCN7A

5.28e-09116286CID000003878
DrugAC1L1MOZ

SCN3A SCN4A SCN5A SCN7A

3.15e-0827284CID000031958
Drugtocainide

SCN3A SCN4A SCN5A SCN7A

4.90e-0830284CID000038945
DrugSodium

CACNA1E SCN2A SCN3A SCN5A SCN8A

5.57e-0884285ctd:D012964
DrugNSC7524

CACNA1E SCN2A SCN3A SCN4A SCN5A SCN7A

7.82e-08182286CID000005657
Drug2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate

SCN2A SCN3A SCN8A

9.29e-088283ctd:C489827
Drugbenzocaine

SCN2A SCN3A SCN4A SCN7A

1.17e-0737284CID000002337
DrugTetrodotoxin

SCN2A SCN3A SCN5A SCN8A

1.62e-0740284ctd:D013779
Drugpyraclofos

KCNA10 SCN2A SCN4A SCN5A SCN7A

1.79e-07106285CID000093460
Drugphenytoin

CACNA1E SCN2A SCN3A SCN4A SCN5A SCN7A

2.33e-07219286CID000001775
Drugpilsicainide

SCN3A SCN4A SCN5A SCN7A

2.88e-0746284CID000004820
Drugbepridil

CACNA1E SCN3A SCN4A SCN5A SCN7A

4.25e-07126285CID000002351
Drugtetradotoxin

CACNA1E SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

6.65e-07428287CID000020382
Drugsaxitoxin

SCN2A SCN3A SCN4A SCN7A

1.18e-0665284CID000037165
DrugAC1L1CQC

SCN3A SCN4A SCN5A SCN7A

1.18e-0665284CID000002012
Drugmexiletine

SCN3A SCN4A SCN5A SCN7A

1.25e-0666284CID000004178
Drugdisopyramide

SCN3A SCN4A SCN5A SCN7A

1.25e-0666284CID000003114
DrugScorpion Venoms

SCN2A SCN3A SCN4A

1.34e-0618283ctd:D012604
Drugdibucaine

SCN3A SCN4A SCN5A SCN7A

1.41e-0668284CID000003025
Drugmu-conotoxin KIIIA, Conus kinoshitai

SCN2A SCN4A

1.46e-062282ctd:C502265
DrugPhenytoin

SCN1A SCN5A

1.46e-062282DB00252
DrugFlecainide

SCN4A SCN5A

1.46e-062282DB01195
Drugdiprafenone

SCN3A SCN4A SCN7A

1.59e-0619283CID000071249
Drugverapamil

CACNA1E KCNA10 ABCA7 SCN3A SCN4A SCN5A SCN7A

1.64e-06490287CID000002520
Drugflecainide

SCN3A SCN4A SCN5A SCN7A

1.68e-0671284CID000003355
Druggabapentin

CACNA1E SCN3A SCN4A SCN5A SCN7A

1.82e-06169285CID000003446
Drug1, 3-diallylurea

CACNA1E SCN3A SCN4A SCN7A

1.98e-0674284CID000074537
Drugriluzole

CACNA1E SCN3A SCN4A SCN5A SCN7A

2.10e-06174285CID000005070
Drugcarbamazepine

SCN2A SCN3A SCN4A SCN5A SCN7A

2.41e-06179285CID000002554
DrugAC1NT1AF

SCN3A SCN4A SCN7A

3.76e-0625283CID005322157
DrugPirmenolum

SCN3A SCN4A SCN7A

4.25e-0626283CID000004853
DrugDB08666

SCN2A SCN4A SCN5A SCN7A

4.35e-0690284CID011840988
DrugN-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide

SCN3A SCN4A

4.37e-063282ctd:C561228
Drugnefopam

SCN3A SCN4A SCN7A

4.78e-0627283CID000004450
DrugPbTx-1

SCN3A SCN4A SCN7A

4.78e-0627283CID006437089
Drugparaben

SCN3A SCN4A SCN7A

5.35e-0628283CID000007175
Drugpropafenone

SCN3A SCN4A SCN5A SCN7A

6.10e-0698284CID000004932
Drugquindine

KCNA10 SCN3A SCN4A SCN5A SCN7A

6.45e-06219285CID000001065
Drugisradipine

CACNA1E SCN3A SCN4A SCN7A

6.61e-06100284CID000003784
DrugNSC93767

SCN3A SCN4A SCN7A

8.07e-0632283CID000005658
DrugFospropofol

SCN2A SCN4A

8.74e-064282DB06716
DrugAPETx2 protein, Anthopleura elegantissima

SCN2A SCN8A

8.74e-064282ctd:C501880
DrugPropofol

SCN2A SCN4A

8.74e-064282DB00818
Drug5-hydroxypropafenone

SCN3A SCN4A SCN7A

9.72e-0634283CID000107927
Drugsodium

ATP12A SERPINA6 SLC29A1 SCN2A SCN3A SCN4A SCN5A SCN7A

1.26e-05944288CID000000923
Drugsipatrigine

CACNA1E SCN2A SCN4A

1.26e-0537283CID000060803
Drugaprindine

SCN3A SCN4A SCN7A

1.37e-0538283CID000002218
DrugS-ropivacaine

SCN3A SCN4A SCN7A

1.60e-0540283CID000071273
Drugpotassium

CACNA1E ATP12A KCNA10 SCN2A SCN3A SCN4A SCN5A SCN7A

2.02e-051008288CID000000813
Drugfenpropathrin

SCN2A SCN3A

2.18e-056282ctd:C044267
Drugspiradoline

SCN3A SCN4A SCN7A

2.44e-0546283CID000005620
Drugdecamethrin

SCN1A SCN2A SCN3A SCN8A

2.95e-05146284ctd:C017180
Drugindoxacarb

SCN3A SCN4A SCN7A

2.95e-0549283CID000107720
Drugfluorocyclobutane

SCN2A SCN4A

3.05e-057282CID011051569
Drugprocaine

CACNA1E SCN3A SCN4A SCN7A

3.54e-05153284CID000004914
DrugAC1NSN3X

SCN3A SCN4A SCN7A

3.96e-0554283CID005366189
Druglidocaine

SCN3A SCN4A SCN5A SCN7A

4.22e-05160284CID000003676
Drugamiodarone

SCN3A SCN4A SCN5A SCN7A

4.22e-05160284CID000002156
Drugtriamterene

SCN3A SCN4A SCN7A

4.91e-0558283CID000005546
Drugzonisamide

SCN3A SCN4A SCN7A

6.00e-0562283CID000005734
Drugresiniferatoxin

SCN3A SCN4A SCN7A

7.24e-0566283CID000104826
Druggastrodin

CACNA1E SCN2A

7.97e-0511282CID000115067
Drugprocainamide

SCN3A SCN4A SCN5A SCN7A

8.22e-05190284CID000004913
DrugGBR 12909

SCN3A SCN4A SCN7A

8.27e-0569283CID000003455
DrugT2755

SCN3A SCN4A SCN7A

9.00e-0571283CID000005514
Drug4-O-methyl-12-O-tetradecanoylphorbol 13-acetate

CACNA1E KCNA10

9.55e-0512282ctd:C020922
DrugIfosfamide [3778-73-2]; Up 200; 15.4uM; PC3; HT_HG-U133A

ZNF214 KCNA10 MFSD13A SCN2A

9.65e-051982845805_UP
DrugCanavanine sulfate monohydrate (L,+) [206996-57-8]; Up 200; 13.6uM; HL60; HT_HG-U133A

ATP12A SERPINA6 SCN5A A4GALT

1.00e-042002842141_UP
Drugimide

SCN3A SCN4A SCN7A

1.02e-0474283CID000443040
Drugdiphenhydramine

SCN3A SCN4A SCN7A

1.06e-0475283CID000003100
Drug20(S)-Propanaxidiol

SCN2A SCN4A

1.13e-0413282CID005317623
Drugbupropion

SCN3A SCN4A SCN7A

1.33e-0481283CID000000444
Drugnonanol

SCN2A SCN4A

1.52e-0415282CID000008914
DrugPD 150606

SCN2A SCN3A

1.96e-0417282ctd:C100442
Drugtetrapentylammonium

SCN4A SCN5A

1.96e-0417282CID000017248
Drugmoricizine

SCN4A SCN5A

2.20e-0418282CID000034632
DrugU1-1

SCN2A SCN4A SCN7A

2.34e-0498283CID006914645
Drugtrimethoprim

SCN3A SCN4A SCN7A

2.41e-0499283CID000005578
DrugAC1NRC8M

SCN2A SCN3A

2.46e-0419282CID005288877
DrugAC1NPPZW

SCN2A SCN4A SCN5A

2.71e-04103283CID005183170
Drugmethylparaben

CACNA1E SCN2A

2.73e-0420282CID000007456
Drug1-chloro-1,2,2-trifluorocyclobutane

SCN2A SCN4A

3.96e-0424282CID000079091
Drughydrochlorothiazide

SCN3A SCN4A SCN7A

4.25e-04120283CID000003639
DrugMulticide

SCN2A SCN4A

4.30e-0425282CID000024365
Drugbupivacaine

SCN3A SCN4A SCN7A

4.79e-04125283CID000002474
DrugDPI 201-106

SCN4A SCN5A

5.40e-0428282CID000005190
Drugencainide

SCN4A SCN5A

5.40e-0428282CID000048040
Drugcyfluthrin

SCN2A SCN3A

5.80e-0429282ctd:C052570
Drugoxcarbazepine

SCN4A SCN5A

6.21e-0430282CID000034312
DrugAC1L9N2N

CACNA1E SCN5A

6.21e-0430282CID000449393
Drugclenbuterol

SCN3A SCN4A SCN7A

6.94e-04142283CID000002783
DrugGTP[S]

HAT1 CACNA1E SCN3A SCN4A SCN7A

6.94e-04591285CID000001764
DrugAC1MU9VM

SCN2A SCN7A

7.07e-0432282CID003637526
Drugsalbutamol

SCN3A SCN4A SCN7A

7.52e-04146283CID000002083
DrugNSC15627

SCN4A SCN5A

7.99e-0434282CID000002073
Drug1,2-dichlorohexafluorocyclobutane

SCN2A SCN4A

9.46e-0437282CID000009643
Drugdihydrochloride

SCN3A SCN4A SCN7A

9.63e-04159283CID000070978
DrugPrestwick_523

SLC29A1 SCN5A

1.05e-0339282CID000003687
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

3.67e-2010287DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

3.67e-2010287DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

2.42e-1912287DOID:0060170 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

CACNA1E ATP12A KCNA10 SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A

2.41e-161632810DOID:1826 (implicated_via_orthology)
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN2A SCN3A

1.16e-0622283DOID:2030 (implicated_via_orthology)
DiseaseBenign familial infantile epilepsy

SCN2A SCN8A

2.60e-063282cv:C5575231
DiseaseFamilial benign neonatal epilepsy

SCN2A SCN8A

1.30e-056282C0220669
DiseaseSeizure, Febrile, Simple

SCN1A SCN2A

1.82e-057282C0149886
DiseaseSeizure, Febrile, Complex

SCN1A SCN2A

1.82e-057282C0751057
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1A SCN2A

3.11e-059282C3502809
DiseaseFebrile Convulsions

SCN1A SCN2A

3.11e-059282C0009952
Diseaselactosyl-N-nervonoyl-sphingosine (d18:1/24:1) measurement

ABCA7 A4GALT

3.11e-059282EFO_0800517
DiseaseEpilepsy, Cryptogenic

SCN1A SCN2A SCN8A

6.44e-0582283C0086237
DiseaseAwakening Epilepsy

SCN1A SCN2A SCN8A

6.44e-0582283C0751111
DiseaseAura

SCN1A SCN2A SCN8A

6.44e-0582283C0236018
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN2A

6.73e-0513282C0751122
DiseaseMMR-related febrile seizures

SCN1A SCN2A

9.05e-0515282EFO_0006519
DiseaseNeurodevelopmental Disorders

SCN1A SCN2A SCN8A

9.38e-0593283C1535926
DiseaseEarly infantile epileptic encephalopathy with suppression bursts

SCN1A SCN2A

1.03e-0416282C0393706
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SCN2A

1.32e-0418282HP_0002373
DiseaseEpilepsy

SCN1A SCN2A SCN8A

1.50e-04109283C0014544
Diseasesphingolipid measurement

ABCA7 A4GALT

6.62e-0440282EFO_0004622
DiseaseIntellectual Disability

CACNA1E SCN1A SCN3A SCN8A

7.98e-04447284C3714756
DiseaseQRS complex, QRS duration

DDR2 SCN5A

8.38e-0445282EFO_0005054, EFO_0005055

Protein segments in the cluster

PeptideGeneStartEntry
AQFAMWVDAVIFVFS

AGAP1

131

Q9UPQ3
ESTVFFAIFMGIWVT

ANO5

381

Q75V66
VWHFVVSPSFEYTIM

CACNA1E

1471

Q15878
TFFVSIMIYWHVVGE

A4GALT

31

Q9NPC4
MVTVTEEHMPFWQFF

ERGIC2

301

Q96RQ1
AHFIMQWIFQSDSEQ

GVINP1

611

Q7Z2Y8
ATVFFAVFMAVWATV

ANO4

426

Q32M45
VLFDMLTVDEHVWFY

ABCA7

891

Q8IZY2
HFADTWMMFSEITFQ

DDR2

351

Q16832
MTVAHLWFDNQIFVA

ATP12A

401

P54707
SRWEVFMTHLEFLFT

NBAS

1696

A2RRP1
MISWEVVHTVFLFAL

HMCN1

1

Q96RW7
FFMVESTCIVWFTFE

KCNA10

271

Q16322
FLMWFIETASFIDVD

HAT1

181

O14929
FLWFVSMDLVQVFHC

MFSD13A

266

Q14CX5
QPFIIMIFDHFTWSS

SERPINA6

381

P08185
KIVEHNWFETFIVFM

SCN4A

1026

P35499
MFVTTFFCWHVMINA

TEDDM1

196

Q5T9Z0
IVEHSWFETFIIFMI

SCN5A

1201

Q14524
SIVEHNWFETFIVFM

SCN3A

1201

Q9NY46
LTVVFEHDAWFIFFM

SLC29A1

386

Q99808
EHNWFETFIVFMILL

SCN1A

1216

P35498
EHNWFETFIVFMILL

SCN2A

1206

Q99250
EHNWFETFIIFMILL

SCN8A

1196

Q9UQD0
IHWFSIFNSFMMVIF

TM9SF3

221

Q9HD45
TIAWNIFDFMVVIFS

SCN7A

1311

Q01118
MAVTFEDVTIIFTWE

ZNF214

1

Q9UL59
TFHFQREEKFWIMET

ZNF284

56

Q2VY69