Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	7.71e-06	55	46	4	GO:0042974
GeneOntologyMolecularFunction	Krueppel-associated box domain binding	HDAC1 HDAC2	1.56e-05	3	46	2	GO:0035851
GeneOntologyMolecularFunction	mannosyltransferase activity	ALG3 POMT1 ALG12	3.60e-05	28	46	3	GO:0000030
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	3.78e-05	82	46	4	GO:1990756
GeneOntologyMolecularFunction	protein decrotonylase activity	HDAC1 HDAC2	5.17e-05	5	46	2	GO:0160008
GeneOntologyMolecularFunction	histone decrotonylase activity	HDAC1 HDAC2	5.17e-05	5	46	2	GO:0160009
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	6.73e-05	95	46	4	GO:0140767
GeneOntologyMolecularFunction	transcription factor binding	MYBBP1A PRAMEF1 PRAMEF2 PRAMEF13 ICMT PRAMEF14 HDAC1 HDAC2	2.88e-04	753	46	8	GO:0008134
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	PRAMEF1 PRAMEF2 PRAMEF13 ICMT PRAMEF14 HDAC1 HDAC2	3.44e-04	582	46	7	GO:0140297
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14 HDAC1 HDAC2	3.70e-04	417	46	6	GO:0061629
GeneOntologyMolecularFunction	nuclear receptor binding	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	8.94e-04	187	46	4	GO:0016922
GeneOntologyMolecularFunction	histone deacetylase activity	HDAC1 HDAC2	1.39e-03	24	46	2	GO:0004407
GeneOntologyMolecularFunction	protein lysine deacetylase activity	HDAC1 HDAC2	1.51e-03	25	46	2	GO:0033558
GeneOntologyMolecularFunction	NF-kappaB binding	HDAC1 HDAC2	3.11e-03	36	46	2	GO:0051059
GeneOntologyMolecularFunction	deacetylase activity	HDAC1 HDAC2	3.83e-03	40	46	2	GO:0019213
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCG4 ABCA9	5.70e-03	49	46	2	GO:0140359
GeneOntologyBiologicalProcess	stem cell population maintenance	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14 HDAC1 HDAC2	1.38e-05	237	46	6	GO:0019827
GeneOntologyBiologicalProcess	maintenance of cell number	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14 HDAC1 HDAC2	1.55e-05	242	46	6	GO:0098727
GeneOntologyBiologicalProcess	oogenesis	DIAPH2 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	2.48e-05	156	46	5	GO:0048477
GeneOntologyBiologicalProcess	blastocyst formation	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	2.74e-05	78	46	4	GO:0001825
GeneOntologyBiologicalProcess	fungiform papilla formation	HDAC1 HDAC2	2.91e-05	4	46	2	GO:0061198
GeneOntologyBiologicalProcess	oocyte development	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	6.98e-05	99	46	4	GO:0048599
GeneOntologyBiologicalProcess	hair follicle placode formation	HDAC1 HDAC2	7.26e-05	6	46	2	GO:0060789
GeneOntologyBiologicalProcess	fungiform papilla morphogenesis	HDAC1 HDAC2	7.26e-05	6	46	2	GO:0061197
GeneOntologyBiologicalProcess	oocyte differentiation	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	8.15e-05	103	46	4	GO:0009994
GeneOntologyBiologicalProcess	somatic stem cell population maintenance	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	9.79e-05	108	46	4	GO:0035019
GeneOntologyBiologicalProcess	fungiform papilla development	HDAC1 HDAC2	1.01e-04	7	46	2	GO:0061196
GeneOntologyBiologicalProcess	female gamete generation	DIAPH2 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.35e-04	223	46	5	GO:0007292
GeneOntologyBiologicalProcess	negative regulation of apoptotic process	FGG MAPK7 PRAMEF1 PRAMEF2 PRAMEF13 PIK3CG PRAMEF14 HDAC1 HDAC2 TMBIM4	1.60e-04	1133	46	10	GO:0043066
GeneOntologyBiologicalProcess	negative regulation of programmed cell death	FGG MAPK7 PRAMEF1 PRAMEF2 PRAMEF13 PIK3CG PRAMEF14 HDAC1 HDAC2 TMBIM4	2.09e-04	1171	46	10	GO:0043069
GeneOntologyBiologicalProcess	phospholipase C-activating G protein-coupled receptor signaling pathway	P2RY10 NPR3 GPR157 PIK3CG	2.19e-04	133	46	4	GO:0007200
GeneOntologyBiologicalProcess	tongue morphogenesis	HDAC1 HDAC2	3.17e-04	12	46	2	GO:0043587
GeneOntologyBiologicalProcess	anatomical structure formation involved in morphogenesis	CHAD NPR3 MAPK7 PRAMEF1 PRAMEF2 PRAMEF13 PIK3CG PRAMEF14 HDAC1 HDAC2 JAM2	3.27e-04	1483	46	11	GO:0048646
GeneOntologyBiologicalProcess	ectodermal placode morphogenesis	HDAC1 HDAC2	5.72e-04	16	46	2	GO:0071697
GeneOntologyBiologicalProcess	eyelid development in camera-type eye	HDAC1 HDAC2	5.72e-04	16	46	2	GO:0061029
GeneOntologyBiologicalProcess	ectodermal placode formation	HDAC1 HDAC2	5.72e-04	16	46	2	GO:0060788
GeneOntologyBiologicalProcess	circadian regulation of gene expression	MYBBP1A HDAC1 HDAC2	6.26e-04	75	46	3	GO:0032922
GeneOntologyBiologicalProcess	germ cell development	DIAPH2 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14 JAM2	6.69e-04	482	46	6	GO:0007281
GeneOntologyBiologicalProcess	blastocyst development	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	6.73e-04	179	46	4	GO:0001824
GeneOntologyBiologicalProcess	ectodermal placode development	HDAC1 HDAC2	7.28e-04	18	46	2	GO:0071696
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	3.73e-06	47	47	4	GO:0031462
GeneOntologyCellularComponent	SWI/SNF superfamily-type complex	MYBBP1A INO80 HDAC1 HDAC2	6.40e-05	96	47	4	GO:0070603
GeneOntologyCellularComponent	ATPase complex	MYBBP1A INO80 HDAC1 HDAC2	2.01e-04	129	47	4	GO:1904949
GeneOntologyCellularComponent	NuRD complex	HDAC1 HDAC2	6.59e-04	17	47	2	GO:0016581
GeneOntologyCellularComponent	CHD-type complex	HDAC1 HDAC2	6.59e-04	17	47	2	GO:0090545
GeneOntologyCellularComponent	Sin3-type complex	HDAC1 HDAC2	1.11e-03	22	47	2	GO:0070822
GeneOntologyCellularComponent	acrosomal vesicle	POMT1 PRAMEF1 PRAMEF2 PRAMEF13	1.17e-03	206	47	4	GO:0001669
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.30e-03	212	47	4	GO:0031461
GeneOntologyCellularComponent	lumenal side of endoplasmic reticulum membrane	ALG3 ALG12	2.81e-03	35	47	2	GO:0098553
MousePheno	abnormal spermatogonia proliferation	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	6.11e-06	47	36	4	MP:0002685
MousePheno	increased circulating amylase level	PRAMEF1 PRAMEF2 RNF145 PRAMEF13 PRAMEF14	1.25e-05	119	36	5	MP:0008806
MousePheno	abnormal kidney weight	KISS1R HSD17B3 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.36e-05	208	36	6	MP:0002707
MousePheno	decreased testis weight	KISS1R HSD17B3 PRAMEF1 CCDC183 PRAMEF2 PRAMEF13 PRAMEF14	3.70e-05	370	36	7	MP:0004852
MousePheno	abnormal circulating amylase level	PRAMEF1 PRAMEF2 RNF145 PRAMEF13 PRAMEF14	4.63e-05	156	36	5	MP:0008804
MousePheno	abnormal testis weight	KISS1R HSD17B3 PRAMEF1 CCDC183 PRAMEF2 PRAMEF13 PRAMEF14	5.26e-05	391	36	7	MP:0004850
MousePheno	abnormal seminal vesicle morphology	INO80 KISS1R HSD17B3 PRAMEF1 PRAMEF2 PRAMEF13	1.47e-04	319	36	6	MP:0002059
MousePheno	abnormal jejunum morphology	PRAMEF1 PRAMEF2 PRAMEF13	1.56e-04	41	36	3	MP:0004002
MousePheno	small testis	NPR3 KISS1R HSD17B3 PRAMEF1 CCDC183 PRAMEF2 PRAMEF13 PRAMEF14 HDAC2	1.81e-04	823	36	9	MP:0001147
MousePheno	abnormal male accessory sex gland morphology	INO80 KISS1R HSD17B3 PRAMEF1 PRAMEF2 PRAMEF13	2.75e-04	358	36	6	MP:0013330
MousePheno	small gonad	NPR3 KISS1R HSD17B3 PRAMEF1 CCDC183 PRAMEF2 PRAMEF13 PRAMEF14 HDAC2	3.12e-04	885	36	9	MP:0001116
MousePheno	abnormal primary sex determination	NPR3 KISS1R HSD17B3 PRAMEF1 CCDC183 PRAMEF2 PRAMEF13 PRAMEF14 HDAC2	3.57e-04	901	36	9	MP:0002211
MousePheno	azoospermia	KISS1R PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	3.77e-04	244	36	5	MP:0005159
MousePheno	abnormal testis size	NPR3 KISS1R HSD17B3 PRAMEF1 CCDC183 PRAMEF2 PRAMEF13 PRAMEF14 HDAC2	4.00e-04	915	36	9	MP:0004849
MousePheno	absent gametes	KISS1R PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	4.69e-04	256	36	5	MP:0001117
MousePheno	increased kidney weight	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	5.05e-04	145	36	4	MP:0003917
MousePheno	abnormal sex determination	NPR3 KISS1R HSD17B3 PRAMEF1 CCDC183 PRAMEF2 PRAMEF13 PRAMEF14 HDAC2	5.07e-04	945	36	9	MP:0002210
MousePheno	abnormal tail morphology	NPR3 PRAMEF1 PRAMEF2 PRAMEF13 CLEC16A PRAMEF14	5.17e-04	403	36	6	MP:0002111
MousePheno	abnormal duodenum morphology	PRAMEF1 PRAMEF2 PRAMEF13	5.87e-04	64	36	3	MP:0003271
Domain	PRAME_family	PRAMEF1 PRAMEF2 PRAMEF13	1.23e-05	19	45	3	IPR026271
Domain	His_deacetylse_1	HDAC1 HDAC2	3.40e-05	4	45	2	IPR003084
Domain	His_deacetylse_dom	HDAC1 HDAC2	3.08e-04	11	45	2	IPR023801
Domain	Hist_deacetyl	HDAC1 HDAC2	3.08e-04	11	45	2	PF00850
Domain	-	HDAC1 HDAC2	3.08e-04	11	45	2	3.40.800.20
Domain	His_deacetylse	HDAC1 HDAC2	3.08e-04	11	45	2	IPR000286
Domain	Znf_RING-CH	MARCHF10 RNF145	7.54e-04	17	45	2	IPR011016
Domain	RINGv	MARCHF10 RNF145	7.54e-04	17	45	2	SM00744
Domain	ARM-type_fold	DIAPH2 UTP20 MYBBP1A PIK3CG UBR4	1.29e-03	339	45	5	IPR016024
Domain	ABC_TRANSPORTER_2	ABCG4 ABCA9	5.97e-03	48	45	2	PS50893
Domain	ABC_tran	ABCG4 ABCA9	5.97e-03	48	45	2	PF00005
Domain	ABC_TRANSPORTER_1	ABCG4 ABCA9	6.21e-03	49	45	2	PS00211
Domain	ABC_transporter-like	ABCG4 ABCA9	6.46e-03	50	45	2	IPR003439
Domain	-	CHAD PRAMEF1 PRAMEF2 PRAMEF13	7.33e-03	321	45	4	3.80.10.10
Domain	L_dom-like	CHAD PRAMEF1 PRAMEF2 PRAMEF13	7.90e-03	328	45	4	IPR032675
Pathway	WP_HISTONE_MODIFICATIONS	HDAC1 HDAC2	4.66e-05	5	31	2	MM15874
Pathway	REACTOME_P75NTR_NEGATIVELY_REGULATES_CELL_CYCLE_VIA_SC1	HDAC1 HDAC2	6.98e-05	6	31	2	M27072
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_REST_MEDIATED_TRANSCRIPTIONAL_REPRESSION	HDAC1 HDAC2	9.76e-05	7	31	2	M47673
Pathway	WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS	ABCG4 PIK3CG HDAC1 HDAC2	1.27e-04	119	31	4	M48309
Pathway	REACTOME_STAT3_NUCLEAR_EVENTS_DOWNSTREAM_OF_ALK_SIGNALING	HDAC1 HDAC2	2.54e-04	11	31	2	M42523
Pathway	KEGG_MEDICUS_VARIANT_TEL_AML1_FUSION_TO_TRANSCRIPTIONAL_REPRESSION	HDAC1 HDAC2	2.54e-04	11	31	2	M47438
Pathway	BIOCARTA_PRC2_PATHWAY	HDAC1 HDAC2	4.19e-04	14	31	2	M22025
Pathway	BIOCARTA_ERK5_PATHWAY	MAPK7 PIK3CG	4.19e-04	14	31	2	MM1481
Pathway	BIOCARTA_ERK5_PATHWAY	MAPK7 PIK3CG	4.19e-04	14	31	2	M16811
Pathway	KEGG_CHRONIC_MYELOID_LEUKEMIA	PIK3CG HDAC1 HDAC2	5.40e-04	73	31	3	M321
Pathway	REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	ABCG4 ABCA9	6.24e-04	17	31	2	MM14552
Pathway	BIOCARTA_MEF2D_PATHWAY	HDAC1 HDAC2	7.01e-04	18	31	2	M5290
Pathway	REACTOME_MECP2_REGULATES_NEURONAL_RECEPTORS_AND_CHANNELS	HDAC1 HDAC2	7.01e-04	18	31	2	M27901
Pathway	REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	ABCG4 ABCA9	7.01e-04	18	31	2	M524
Pathway	PID_REG_GR_PATHWAY	FGG HDAC1 HDAC2	7.58e-04	82	31	3	M115
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	PSMD3 ALG3 INO80 POMT1 FGG COG1 ICMT ALG12 HDAC1 HDAC2	8.60e-04	1475	31	10	M19806
Pathway	WP_CALCIUM_MEDIATED_TCELL_APOPTOSIS_INVOLVED_IN_INCLUSION_BODY_MYOSITIS	HDAC1 HDAC2	8.68e-04	20	31	2	M48330
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_N_GLYCOSYLATION_OF_PROTEINS	ALG3 ALG12	8.68e-04	20	31	2	M27274
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	9.63e-09	18	48	4	29731491
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	9.63e-09	18	48	4	23894331
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	9.63e-09	18	48	4	14675769
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	9.63e-09	18	48	4	12890732
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.22e-08	19	48	4	28604677
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.52e-08	20	48	4	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.52e-08	20	48	4	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.52e-08	20	48	4	21425410
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	2.29e-08	22	48	4	31729367
Pubmed	Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis.	MYBBP1A HDAC1 HDAC2	2.46e-08	5	48	3	22333916
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	2.77e-08	23	48	4	19480014
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	3.95e-08	25	48	4	37451217
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	3.95e-08	25	48	4	12620990
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	4.67e-08	26	48	4	18500982
Pubmed	Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway.	PIK3CG HDAC1 HDAC2	4.92e-08	6	48	3	19801684
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	6.38e-08	28	48	4	25089626
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	8.52e-08	30	48	4	38786026
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.12e-07	32	48	4	37889087
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.62e-07	35	48	4	19389355
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	4.99e-07	46	48	4	17287250
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	7.02e-07	50	48	4	31806660
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF1 PRAMEF2 PRAMEF13	1.65e-06	17	48	3	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF1 PRAMEF2 PRAMEF13	1.65e-06	17	48	3	37781892
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14 HDAC1 HDAC2 JAM2	1.82e-06	424	48	7	21731673
Pubmed	Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice.	HDAC1 HDAC2	1.87e-06	2	48	2	22307625
Pubmed	The lysine deacetylase activity of histone deacetylases 1 and 2 is required to safeguard zygotic genome activation in mice and cattle.	HDAC1 HDAC2	1.87e-06	2	48	2	35575026
Pubmed	Histone hypoacetylation and increased histone deacetylases in peripheral blood mononuclear cells from patients with Graves' disease.	HDAC1 HDAC2	1.87e-06	2	48	2	26116233
Pubmed	Disrupted ectodermal organ morphogenesis in mice with a conditional histone deacetylase 1, 2 deletion in the epidermis.	HDAC1 HDAC2	1.87e-06	2	48	2	23792463
Pubmed	Dynamic distribution of HDAC1 and HDAC2 during mitosis: association with F-actin.	HDAC1 HDAC2	1.87e-06	2	48	2	23280436
Pubmed	Selective Inhibition of HDAC1 and HDAC2 as a Potential Therapeutic Option for B-ALL.	HDAC1 HDAC2	1.87e-06	2	48	2	25688158
Pubmed	Expression and function of histone deacetylases in rheumatoid arthritis synovial fibroblasts.	HDAC1 HDAC2	1.87e-06	2	48	2	19531758
Pubmed	Histone deacetylase 2 (HDAC2) regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouse.	HDAC1 HDAC2	1.87e-06	2	48	2	23516383
Pubmed	Histone deacetylases 1 and 2 are phosphorylated at novel sites during varicella-zoster virus infection.	HDAC1 HDAC2	1.87e-06	2	48	2	19740981
Pubmed	NuRD and SIN3 histone deacetylase complexes in development.	HDAC1 HDAC2	1.87e-06	2	48	2	10904264
Pubmed	HDAC1 and HDAC2 collectively regulate intestinal stem cell homeostasis.	HDAC1 HDAC2	1.87e-06	2	48	2	25648995
Pubmed	Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro.	HDAC1 HDAC2	1.87e-06	2	48	2	31222845
Pubmed	The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis.	HDAC1 HDAC2	1.87e-06	2	48	2	24525021
Pubmed	Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility.	HDAC1 HDAC2	1.87e-06	2	48	2	17639084
Pubmed	HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1.	HDAC1 HDAC2	1.87e-06	2	48	2	11287668
Pubmed	Differential HDAC1/2 network analysis reveals a role for prefoldin/CCT in HDAC1/2 complex assembly.	HDAC1 HDAC2	1.87e-06	2	48	2	30209338
Pubmed	Essential roles of HDAC1 and 2 in lineage development and genome-wide DNA methylation during mouse preimplantation development.	HDAC1 HDAC2	1.87e-06	2	48	2	31533525
Pubmed	HDAC1 and HDAC2 are differentially expressed in endometriosis.	HDAC1 HDAC2	1.87e-06	2	48	2	22344732
Pubmed	Kidney cell type-specific changes in the chromatin and transcriptome landscapes following epithelial Hdac1 and Hdac2 knockdown.	HDAC1 HDAC2	1.87e-06	2	48	2	34890513
Pubmed	Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts.	HDAC1 HDAC2	1.87e-06	2	48	2	32366868
Pubmed	HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells.	HDAC1 HDAC2	1.87e-06	2	48	2	21423190
Pubmed	HDAC1 and HDAC2 independently regulate common and specific intrinsic responses in murine enteroids.	HDAC1 HDAC2	1.87e-06	2	48	2	30926862
Pubmed	Primary macrophages rely on histone deacetylase 1 and 2 expression to induce type I interferon in response to gammaherpesvirus infection.	HDAC1 HDAC2	1.87e-06	2	48	2	24335310
Pubmed	Attenuation of neuronal ferroptosis in intracerebral hemorrhage by inhibiting HDAC1/2: Microglial heterogenization via the Nrf2/HO1 pathway.	HDAC1 HDAC2	1.87e-06	2	48	2	38523117
Pubmed	Trans-regulation of histone deacetylase activities through acetylation.	HDAC1 HDAC2	1.87e-06	2	48	2	19822520
Pubmed	Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC.	HDAC1 HDAC2	1.87e-06	2	48	2	18408217
Pubmed	Valproic acid targets HDAC1/2 and HDAC1/PTEN/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer.	HDAC1 HDAC2	1.87e-06	2	48	2	31692265
Pubmed	HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia.	HDAC1 HDAC2	1.87e-06	2	48	2	28579617
Pubmed	HDAC1 and HDAC2 Modulate TGF-β Signaling during Endothelial-to-Hematopoietic Transition.	HDAC1 HDAC2	1.87e-06	2	48	2	29641990
Pubmed	HDAC1 and HDAC2 restrain the intestinal inflammatory response by regulating intestinal epithelial cell differentiation.	HDAC1 HDAC2	1.87e-06	2	48	2	24040068
Pubmed	Distinct Roles for Intestinal Epithelial Cell-Specific Hdac1 and Hdac2 in the Regulation of Murine Intestinal Homeostasis.	HDAC1 HDAC2	1.87e-06	2	48	2	26174178
Pubmed	Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumor proliferation.	HDAC1 HDAC2	1.87e-06	2	48	2	15297431
Pubmed	[Regulatory effect of ginsenoside Rh2 on HDAC1/2 activity and cyclin in human erythroleukemia K562 cells].	HDAC1 HDAC2	1.87e-06	2	48	2	25270209
Pubmed	Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells.	HDAC1 HDAC2	1.87e-06	2	48	2	24958871
Pubmed	Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma.	HDAC1 HDAC2	1.87e-06	2	48	2	22156779
Pubmed	Epigenetic targeting of SLC30A3 by HDAC1 is related to the malignant phenotype of glioblastoma.	SLC30A3 HDAC1	1.87e-06	2	48	2	33715270
Pubmed	Histone deacetylase (HDAC) 1 and 2 expression and chemotherapy in gastric cancer.	HDAC1 HDAC2	1.87e-06	2	48	2	20585871
Pubmed	Combined HDAC1 and HDAC2 Depletion Promotes Retinal Ganglion Cell Survival After Injury Through Reduction of p53 Target Gene Expression.	HDAC1 HDAC2	1.87e-06	2	48	2	26129908
Pubmed	Histone deacetylase HDAC1/HDAC2-controlled embryonic development and cell differentiation.	HDAC1 HDAC2	1.87e-06	2	48	2	19412887
Pubmed	A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes.	HDAC1 HDAC2	1.87e-06	2	48	2	19561124
Pubmed	HDAC1 and HDAC2 independently predict mortality in hepatocellular carcinoma by a competing risk regression model in a Southeast Asian population.	HDAC1 HDAC2	1.87e-06	2	48	2	26352599
Pubmed	Leucine zipper domain is required for Kaposi sarcoma-associated herpesvirus (KSHV) K-bZIP protein to interact with histone deacetylase and is important for KSHV replication.	HDAC1 HDAC2	1.87e-06	2	48	2	22416134
Pubmed	Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer.	HDAC1 HDAC2	1.87e-06	2	48	2	23251689
Pubmed	Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity.	HDAC1 HDAC2	1.87e-06	2	48	2	32934238
Pubmed	Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining.	HDAC1 HDAC2	1.87e-06	2	48	2	20802485
Pubmed	Histone deacetylase 1 and 2 in mesenchymal tumors.	HDAC1 HDAC2	1.87e-06	2	48	2	22037263
Pubmed	Loss of histone deacetylase 2 improves working memory and accelerates extinction learning.	HDAC1 HDAC2	1.87e-06	2	48	2	23575838
Pubmed	Inhibition of histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing.	HDAC1 HDAC2	1.87e-06	2	48	2	31799598
Pubmed	Podocyte histone deacetylase activity regulates murine and human glomerular diseases.	HDAC1 HDAC2	1.87e-06	2	48	2	30776024
Pubmed	The binding of histone deacetylases and the integrity of zinc finger-like motifs of the E7 protein are essential for the life cycle of human papillomavirus type 31.	HDAC1 HDAC2	1.87e-06	2	48	2	15016876
Pubmed	Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis.	HDAC1 HDAC2	1.87e-06	2	48	2	21270520
Pubmed	Phosphatase inhibition leads to histone deacetylases 1 and 2 phosphorylation and disruption of corepressor interactions.	HDAC1 HDAC2	1.87e-06	2	48	2	11919195
Pubmed	Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia.	HDAC1 HDAC2	1.87e-06	2	48	2	21292776
Pubmed	Genetic dissection of histone deacetylase requirement in tumor cells.	HDAC1 HDAC2	1.87e-06	2	48	2	19416910
Pubmed	Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice.	HDAC1 HDAC2	1.87e-06	2	48	2	23287868
Pubmed	HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer.	HDAC1 HDAC2	1.87e-06	2	48	2	30669676
Pubmed	HDAC1,2 Knock-Out and HDACi Induced Cell Apoptosis in Imatinib-Resistant K562 Cells.	HDAC1 HDAC2	1.87e-06	2	48	2	31071955
Pubmed	JAK-STAT Pathway Inhibition Partially Restores Intestinal Homeostasis in Hdac1- and Hdac2-Intestinal Epithelial Cell-Deficient Mice.	HDAC1 HDAC2	1.87e-06	2	48	2	33498747
Pubmed	Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy.	HDAC1 HDAC2	1.87e-06	2	48	2	21725353
Pubmed	Histone deacetylases 1 and 2 regulate DNA replication and DNA repair: potential targets for genome stability-mechanism-based therapeutics for a subset of cancers.	HDAC1 HDAC2	1.87e-06	2	48	2	25942572
Pubmed	Regulation of osteogenesis in bone marrow-derived mesenchymal stem cells via histone deacetylase 1 and 2 co-cultured with human gingival fibroblasts and periodontal ligament cells.	HDAC1 HDAC2	1.87e-06	2	48	2	36346011
Pubmed	Histone deacetylases 1 and 2 form a developmental switch that controls excitatory synapse maturation and function.	HDAC1 HDAC2	1.87e-06	2	48	2	19553468
Pubmed	A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog.	HDAC1 HDAC2	1.87e-06	2	48	2	24449838
Pubmed	HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells.	HDAC1 HDAC2	1.87e-06	2	48	2	20398369
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF1 PRAMEF2 PRAMEF13	1.98e-06	18	48	3	39181896
Pubmed	Loss of histone deacetylases 1 and 2 in hepatocytes impairs murine liver regeneration through Ki67 depletion.	HDAC1 HDAC2	5.59e-06	3	48	2	23744762
Pubmed	Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo.	HDAC1 HDAC2	5.59e-06	3	48	2	30279482
Pubmed	HDAC1/2 and HDAC3 play distinct roles in controlling adult Meibomian gland homeostasis.	HDAC1 HDAC2	5.59e-06	3	48	2	38679196
Pubmed	Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy.	HDAC1 HDAC2	5.59e-06	3	48	2	21367693
Pubmed	Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity.	HDAC1 HDAC2	5.59e-06	3	48	2	18172012
Pubmed	Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis.	HDAC1 HDAC2	5.59e-06	3	48	2	24763403
Pubmed	Acetylation-Dependent Control of Global Poly(A) RNA Degradation by CBP/p300 and HDAC1/2.	HDAC1 HDAC2	5.59e-06	3	48	2	27635759
Pubmed	Mutual Balance of Histone Deacetylases 1 and 2 and the Acetyl Reader ATAD2 Regulates the Level of Acetylation of Histone H4 on Nascent Chromatin of Human Cells.	HDAC1 HDAC2	5.59e-06	3	48	2	32015101
Pubmed	Exercise and diabetes have opposite effects on the assembly and O-GlcNAc modification of the mSin3A/HDAC1/2 complex in the heart.	HDAC1 HDAC2	5.59e-06	3	48	2	23835259
Pubmed	Retinoic acid and histone deacetylases regulate epigenetic changes in embryonic stem cells.	HDAC1 HDAC2	5.59e-06	3	48	2	24821725
Pubmed	Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development.	HDAC1 HDAC2	5.59e-06	3	48	2	22223663
Cytoband	1p36.21	PRAMEF1 PRAMEF2 PRAMEF13 ICMT PRAMEF14	6.77e-09	63	48	5	1p36.21
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	PRAMEF1 PRAMEF2 PRAMEF13 ICMT GPR157 PRAMEF14 UBR4	6.66e-06	681	48	7	chr1p36
GeneFamily	PRAME family	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.37e-07	24	36	4	686
GeneFamily	Dolichyl D-mannosyl phosphate dependent mannosyltransferases\|Phosphatidylinositol glycan anchor biosynthesis	ALG3 POMT1 ALG12	6.04e-07	9	36	3	430
GeneFamily	Histone deacetylases, class I\|EMSY complex\|NuRD complex\|SIN3 histone deacetylase complex	HDAC1 HDAC2	2.31e-05	4	36	2	989
GeneFamily	Histone deacetylases, class I\|EMSY complex\|NuRD complex\|SIN3 histone deacetylase complex	HDAC1 HDAC2	1.38e-04	9	36	2	1306
GeneFamily	PHD finger proteins\|NuRD complex	HDAC1 HDAC2	2.51e-04	12	36	2	1305
GeneFamily	Histone deacetylases, class I\|EMSY complex\|NuRD complex\|SIN3 histone deacetylase complex	HDAC1 HDAC2	2.51e-04	12	36	2	1243
Coexpression	KOHOUTEK_CCNT2_TARGETS	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	1.48e-05	81	48	4	MM938
Coexpression	MORI_SMALL_PRE_BII_LYMPHOCYTE_UP	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	3.15e-05	98	48	4	MM592
Coexpression	HUANG_GATA2_TARGETS_DN	PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14	3.15e-05	98	48	4	MM942
Coexpression	KINNEY_DNMT1_METHYLATION_TARGETS	PRAMEF1 PRAMEF2 PRAMEF13	3.31e-05	34	48	3	MM955
ToppCell	Sepsis-ICU-SEP-Lymphocyte-B-B_memory\|ICU-SEP / Disease, condition lineage and cell class	P2RY10 CHAD KISS1R P2RX5 JAM2	2.30e-06	198	48	5	4ba2eb32889bbf043f4bbb822e08eb45a2b576ef
Disease	Congenital disorder of glycosylation	ALG3 COG1 ALG12	2.69e-05	38	45	3	cv:C0282577
Disease	ARTHROGRYPOSIS, DISTAL, TYPE 2B	PIEZO2 NALCN	3.40e-05	6	45	2	C1834523
Disease	Distal arthrogryposis	PIEZO2 NALCN	8.13e-05	9	45	2	cv:C0265213
Disease	alopecia areata (is_marker_for)	HDAC1 HDAC2	1.02e-04	10	45	2	DOID:986 (is_marker_for)
Disease	acute lymphoblastic leukemia (is_marker_for)	HDAC1 HDAC2	1.24e-03	34	45	2	DOID:9952 (is_marker_for)
Disease	cervix uteri carcinoma in situ (is_marker_for)	HDAC1 HDAC2	1.88e-03	42	45	2	DOID:8991 (is_marker_for)
Disease	immunoglobulin isotype switching measurement	PSMD3 UBR4	2.07e-03	44	45	2	EFO_0010128
Disease	diabetic retinopathy (biomarker_via_orthology)	NPR3 PIK3CG	2.16e-03	45	45	2	DOID:8947 (biomarker_via_orthology)
Disease	atopic asthma	PSMD3 RFTN2 CLEC16A	3.48e-03	199	45	3	EFO_0010638
Disease	pulmonary hypertension (is_marker_for)	HDAC1 HDAC2	4.32e-03	64	45	2	DOID:6432 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FFLALRLLAYLVLRY	ABCG4	626	Q9H172
IVYLALLIPYLHFLI	ABCA9	1201	Q8IUA7
LYLATLLLVFLIYHQ	ALG3	131	Q92685
LIYLYLSHNDIRVLR	CHAD	101	O15335
LSILQHFLLIRNDYY	DIAPH2	426	O60879
LYSLLPHKELRFIIY	ALG12	301	Q9BV10
LLYVLALHEVLRAGY	NPR3	366	P17342
HLPASYLYRVVLLRL	RFTN2	91	Q52LD8
YLQYLERALRLDHFL	INO80	21	Q9ULG1
LEHVRYFLYQLLRGL	MAPK7	156	Q13164
SLYLDIINLFLHLLR	TMBIM4	216	Q9HC24
LELLKYHQRVLYIDI	HDAC1	161	Q13547
ERAFALYNLLALYLL	KISS1R	201	Q969F8
LEALREYLYFLKHLN	KRT78	236	Q8N1N4
LLLLRYLVVALGYHK	JAM2	11	P57087
FPREYLLQQIHLYSL	PLEKHM3	631	Q6ZWE6
LYHFNASLYLLRVLK	MYBBP1A	921	Q9BQG0
LISNLPLRVDYYLLH	OXER1	141	Q8TDS5
LYLLFFYVHLILVFR	POMT1	276	Q9Y6A1
HPRNLILYFYALLFL	FGG	6	P02679
LYVAGLNALLLLLYR	ICMT	46	O60725
ALQLLYDLRYLNIVL	COG1	806	Q8WTW3
AYVLLPLLYLLVRKH	GPR157	181	Q5UAW9
QNIHLLYLDLLDYLK	CCDC183	166	Q5T5S1
LKNLYFLYLIELRAL	ERO1A	301	Q96HE7
SGLYLVLLLHLYEQR	MARCHF10	746	Q8NA82
ILELLKYHQRVLYID	HDAC2	161	Q92769
FQRLLLTHYVAYLKL	HSD17B3	291	P37058
YLKHLNLSYVLLFRI	PRAMEF13	321	Q5VWM6
LAHVLSLPLRIYYYI	P2RY10	81	O00398
LLYRLLQASILAYLV	P2RX5	31	Q93086
NLLFAAKVLYLLELY	UTP20	2556	O75691
FSYPHRYLVLDLALL	TMEM80	121	Q96HE8
YLKHLNLSYVLLFRI	PRAMEF14	321	Q5SWL7
YLKHLNLSYVLLFRI	PRAMEF1	321	O95521
YLKHLNLSYVLLFRI	PRAMEF2	321	O60811
DHLLNRLFLPLYVYS	CLEC16A	281	Q2KHT3
LYYVNLLLIDHRFLL	PIK3CG	461	P48736
HYQYLLLLFLHESLI	UHRF1BP1L	821	A0JNW5
IFLLYLTIIFLHIYK	TMEM68	61	Q96MH6
LNLLLRNYLHYSLYD	PSMD3	251	O43242
LHYLRKLTELLFPYI	SNX14	241	Q9Y5W7
VLYDLIQLLALFFHR	PIEZO2	2016	Q9H5I5
LYLAFVRLLHSDYHI	SLC30A3	161	Q99726
ARLLLIFDYLLHQYS	UBR4	856	Q5T4S7
HLVQLYLYFLTALLL	RNF145	76	Q96MT1
LLQTYLPQLFYHLRE	TBC1D19	421	Q8N5T2
DHYQYLALLRLKEVL	UHRF1BP1	831	Q6BDS2
NAHRYYIHLLLSLFL	TMEM272	101	A0A1B0GTI8
AIYFILYHLFATLIL	NALCN	576	Q8IZF0