Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	superoxide-generating NADPH oxidase activator activity	NCF1 NCF1C NCF1B	1.56e-05	10	103	3	GO:0016176
GeneOntologyMolecularFunction	superoxide-generating NAD(P)H oxidase activity	NCF1 NCF1C NCF1B	2.83e-05	12	103	3	GO:0016175
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DYNC2H1 DNAH17 DYNC1H1	1.03e-04	18	103	3	GO:0008569
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	NCF1 NCF1C NCF1B	1.43e-04	20	103	3	GO:0050664
GeneOntologyMolecularFunction	indanol dehydrogenase activity	AKR1B10 AKR1B15	1.57e-04	4	103	2	GO:0047718
GeneOntologyMolecularFunction	allyl-alcohol dehydrogenase activity	AKR1B10 AKR1B15	1.57e-04	4	103	2	GO:0047655
GeneOntologyMolecularFunction	lipid binding	NCF1 SMURF1 PPARD GSDMC GSTA3 ITPR1 SYT16 MAP1LC3C AKR1B10 APOL6 AKR1B15 PRKCA PLD1 NCF1C NCF1B	1.62e-04	988	103	15	GO:0008289
GeneOntologyMolecularFunction	histone modifying activity	HDAC9 SETD1A SETMAR RPS6KA5 MIER1 PRKCA ATM	1.86e-04	229	103	7	GO:0140993
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	FLT1 RPS6KA5 STK17A PDPK1 TSSK2 RET PI4KB PRKCA ATM PIPSL TSSK1B MAP4K4	2.91e-04	709	103	12	GO:0016773
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PI4KB ATM PIPSL	3.18e-04	26	103	3	GO:0052742
GeneOntologyMolecularFunction	geranylgeranyl reductase activity	AKR1B10 AKR1B15	3.90e-04	6	103	2	GO:0045550
GeneOntologyMolecularFunction	histone kinase activity	RPS6KA5 PRKCA ATM	3.98e-04	28	103	3	GO:0035173
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DYNC2H1 DNAH17 DYNC1H1	3.98e-04	28	103	3	GO:0051959
GeneOntologyMolecularFunction	kinase activity	FLT1 RPS6KA5 STK17A PDPK1 TSSK2 RET PI4KB PRKCA ATM PIPSL TSSK1B MAP4K4	5.69e-04	764	103	12	GO:0016301
GeneOntologyMolecularFunction	protein serine kinase activity	RPS6KA5 STK17A PDPK1 TSSK2 PRKCA ATM TSSK1B MAP4K4	5.86e-04	363	103	8	GO:0106310
GeneOntologyMolecularFunction	phosphatidylinositol-3,4-bisphosphate binding	NCF1 NCF1C NCF1B	7.74e-04	35	103	3	GO:0043325
GeneOntologyMolecularFunction	dynein intermediate chain binding	DYNC2H1 DNAH17 DYNC1H1	9.12e-04	37	103	3	GO:0045505
GeneOntologyMolecularFunction	NADP+ binding	AKR1B10 AKR1B15	9.26e-04	9	103	2	GO:0070401
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	FLT1 RPS6KA5 STK17A PDPK1 TSSK2 RET PI4KB PRKCA ATM PIPSL TSSK1B MAP4K4 TENT2	1.06e-03	938	103	13	GO:0016772
GeneOntologyMolecularFunction	protein kinase activity	FLT1 RPS6KA5 STK17A PDPK1 TSSK2 RET PRKCA ATM TSSK1B MAP4K4	1.07e-03	600	103	10	GO:0004672
GeneOntologyMolecularFunction	lipid kinase activity	PI4KB ATM PIPSL	1.23e-03	41	103	3	GO:0001727
GeneOntologyMolecularFunction	ATP-dependent activity	ATP5PF MYH7 SETX DYNC2H1 PSMC1 ATAD2 MDN1 DNAH17 DYNC1H1 SLC27A4	1.27e-03	614	103	10	GO:0140657
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H	NCF1 RTN4IP1 NCF1C NCF1B	1.48e-03	95	103	4	GO:0016651
GeneOntologyMolecularFunction	histone H3 kinase activity	RPS6KA5 PRKCA	1.68e-03	12	103	2	GO:0140996
GeneOntologyMolecularFunction	phospholipid binding	NCF1 SMURF1 GSDMC ITPR1 SYT16 MAP1LC3C PLD1 NCF1C NCF1B	2.11e-03	548	103	9	GO:0005543
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	RPS6KA5 STK17A PDPK1 TSSK2 PRKCA ATM TSSK1B MAP4K4	2.18e-03	446	103	8	GO:0004674
GeneOntologyMolecularFunction	aldose reductase (NADPH) activity	AKR1B10 AKR1B15	2.30e-03	14	103	2	GO:0004032
GeneOntologyMolecularFunction	retinal dehydrogenase activity	AKR1B10 AKR1B15	2.30e-03	14	103	2	GO:0001758
GeneOntologyMolecularFunction	all-trans-retinol dehydrogenase (NADP+) activity	AKR1B10 AKR1B15	2.65e-03	15	103	2	GO:0052650
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYH7 DYNC2H1 DNAH17 DYNC1H1	3.27e-03	118	103	4	GO:0003774
GeneOntologyBiologicalProcess	neutrophil-mediated killing of gram-positive bacterium	NCF1 NCF1C NCF1B	1.13e-06	5	101	3	GO:0070946
GeneOntologyBiologicalProcess	NADP catabolic process	NCF1 NCF1C NCF1B	3.93e-06	7	101	3	GO:0006742
GeneOntologyBiologicalProcess	neutrophil-mediated killing of fungus	NCF1 NCF1C NCF1B	3.93e-06	7	101	3	GO:0070947
GeneOntologyBiologicalProcess	NADP metabolic process	NCF1 PC NCF1C NCF1B G6PD	7.98e-06	56	101	5	GO:0006739
GeneOntologyBiologicalProcess	regulation of respiratory burst involved in inflammatory response	NCF1 NCF1C NCF1B	1.83e-05	11	101	3	GO:0060264
GeneOntologyBiologicalProcess	respiratory burst involved in inflammatory response	NCF1 NCF1C NCF1B	3.15e-05	13	101	3	GO:0002536
GeneOntologyBiologicalProcess	positive regulation of cell motility	HDAC9 FLT1 PDPK1 SLC26A5 ELP6 RET ARHGAP5 PRKCA ATM PLD1 MAP4K4 SMURF2 NOTCH1	5.32e-05	725	101	13	GO:2000147
GeneOntologyBiologicalProcess	neutrophil-mediated killing of bacterium	NCF1 NCF1C NCF1B	6.09e-05	16	101	3	GO:0070944
GeneOntologyBiologicalProcess	positive regulation of locomotion	HDAC9 FLT1 PDPK1 SLC26A5 ELP6 RET ARHGAP5 PRKCA ATM PLD1 MAP4K4 SMURF2 NOTCH1	6.73e-05	742	101	13	GO:0040017
GeneOntologyBiologicalProcess	response to yeast	NCF1 NCF1C NCF1B	8.82e-05	18	101	3	GO:0001878
GeneOntologyBiologicalProcess	neutrophil-mediated killing of symbiont cell	NCF1 NCF1C NCF1B	1.04e-04	19	101	3	GO:0070943
GeneOntologyBiologicalProcess	respiratory burst involved in defense response	NCF1 NCF1C NCF1B	1.22e-04	20	101	3	GO:0002679
GeneOntologyBiologicalProcess	organelle assembly	MYH7 DYNC2H1 MYOM3 SMURF1 CEP192 CEP350 CSDE1 MDN1 MAP1LC3C CFAP221 DNAH17 ATM LRBA PSPC1 DYNC1H1 NOTCH1	1.26e-04	1138	101	16	GO:0070925
GeneOntologyBiologicalProcess	positive regulation of cell migration	HDAC9 FLT1 PDPK1 ELP6 RET ARHGAP5 PRKCA ATM PLD1 MAP4K4 SMURF2 NOTCH1	1.42e-04	691	101	12	GO:0030335
GeneOntologyBiologicalProcess	neutrophil mediated cytotoxicity	NCF1 NCF1C NCF1B	1.42e-04	21	101	3	GO:0070942
GeneOntologyBiologicalProcess	negative regulation of smooth muscle contraction	NCF1 NCF1C NCF1B	1.64e-04	22	101	3	GO:0045986
GeneOntologyBiologicalProcess	hydrogen peroxide biosynthetic process	NCF1 NCF1C NCF1B	1.64e-04	22	101	3	GO:0050665
GeneOntologyBiologicalProcess	regulation of muscle system process	FLT1 MYH7 NCF1 PRKCA NCF1C NCF1B G6PD NOTCH1	1.67e-04	317	101	8	GO:0090257
GeneOntologyBiologicalProcess	epithelial cell proliferation	FLT1 HTRA1 PDPK1 NCF1 PPARD ITPR1 PRKCA CDC25A NCF1C NCF1B NOTCH1	1.79e-04	603	101	11	GO:0050673
GeneOntologyBiologicalProcess	regulation of respiratory burst	NCF1 NCF1C NCF1B	1.88e-04	23	101	3	GO:0060263
GeneOntologyCellularComponent	NADPH oxidase complex	NCF1 NCF1C NCF1B	8.98e-05	18	103	3	GO:0043020
MousePheno	abnormal angiotensin I-converting enzyme activity	NCF1 NCF1C NCF1B	4.44e-06	6	86	3	MP:0013254
MousePheno	increased angiotensin I-converting enzyme activity	NCF1 NCF1C NCF1B	4.44e-06	6	86	3	MP:0003184
MousePheno	liver abscess	NCF1 NCF1C NCF1B	7.73e-06	7	86	3	MP:0003332
MousePheno	abnormal metabolism	ANKRD31 SETX NCF1 RET PPARD CSDE1 RNH1 AKR1B10 APOL6 AKR1B15 PRKCA ATM PLD1 HERC2 CDC25A NCF1C NCF1B WDR24	1.23e-05	936	86	18	MP:0005266
MousePheno	impaired granulocyte bactericidal activity	NCF1 NCF1C NCF1B	2.62e-05	10	86	3	MP:0005074
MousePheno	abnormal redox activity	NCF1 AKR1B10 AKR1B15 ATM NCF1C NCF1B G6PD	9.30e-05	173	86	7	MP:0003186
MousePheno	decreased susceptibility to Orthomyxoviridae infection	NCF1 NCF1C NCF1B	1.72e-04	18	86	3	MP:0020947
Domain	HECT	UBE3B SMURF1 HERC2 SMURF2	1.09e-05	27	97	4	PF00632
Domain	HECTc	UBE3B SMURF1 HERC2 SMURF2	1.09e-05	27	97	4	SM00119
Domain	HECT_dom	UBE3B SMURF1 HERC2 SMURF2	1.09e-05	27	97	4	IPR000569
Domain	HECT	UBE3B SMURF1 HERC2 SMURF2	1.09e-05	27	97	4	PS50237
Domain	WD40_repeat	DMXL2 WDR64 COPA NUP214 TLE1 LRBA HERC2 TAF5 WDR24	1.21e-05	272	97	9	IPR001680
Domain	ATPase_dyneun-rel_AAA	DYNC2H1 MDN1 DYNC1H1	4.74e-05	14	97	3	IPR011704
Domain	AAA_5	DYNC2H1 MDN1 DYNC1H1	4.74e-05	14	97	3	PF07728
Domain	WD40	DMXL2 WDR64 COPA NUP214 TLE1 LRBA TAF5 WDR24	7.77e-05	268	97	8	SM00320
Domain	WD_REPEATS_1	DMXL2 WDR64 COPA TLE1 LRBA HERC2 TAF5 WDR24	1.00e-04	278	97	8	PS00678
Domain	WD_REPEATS_2	DMXL2 WDR64 COPA TLE1 LRBA HERC2 TAF5 WDR24	1.03e-04	279	97	8	PS50082
Domain	WD_REPEATS_REGION	DMXL2 WDR64 COPA TLE1 LRBA HERC2 TAF5 WDR24	1.03e-04	279	97	8	PS50294
Domain	Kinase-like_dom	FLT1 RPS6KA5 STK17A PDPK1 TSSK2 RET PI4KB PRKCA ATM TSSK1B MAP4K4	1.16e-04	542	97	11	IPR011009
Domain	Protein_kinase_ATP_BS	FLT1 RPS6KA5 STK17A PDPK1 TSSK2 RET PRKCA TSSK1B MAP4K4	1.57e-04	379	97	9	IPR017441
Domain	-	DMXL2 WDR64 COPA NUP214 TLE1 LRBA TAF5 WDR24	3.42e-04	333	97	8	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	DMXL2 WDR64 COPA NUP214 TLE1 LRBA TAF5 WDR24	3.56e-04	335	97	8	IPR015943
Domain	RIH_assoc	RYR3 ITPR1	3.95e-04	6	97	2	PF08454
Domain	RIH_assoc-dom	RYR3 ITPR1	3.95e-04	6	97	2	IPR013662
Domain	RIH_dom	RYR3 ITPR1	3.95e-04	6	97	2	IPR000699
Domain	Ins145_P3_rcpt	RYR3 ITPR1	3.95e-04	6	97	2	IPR014821
Domain	Ryanodine_recept-rel	RYR3 ITPR1	3.95e-04	6	97	2	IPR015925
Domain	-	RYR3 ITPR1	3.95e-04	6	97	2	1.25.10.30
Domain	RYDR_ITPR	RYR3 ITPR1	3.95e-04	6	97	2	PF01365
Domain	Ins145_P3_rec	RYR3 ITPR1	3.95e-04	6	97	2	PF08709
Domain	WD40	DMXL2 WDR64 COPA TLE1 LRBA TAF5 WDR24	4.04e-04	259	97	7	PF00400
Domain	PROTEIN_KINASE_ATP	FLT1 RPS6KA5 STK17A PDPK1 TSSK2 RET PRKCA TSSK1B MAP4K4	6.39e-04	459	97	9	PS00107
Domain	DHC_N1	DYNC2H1 DYNC1H1	7.32e-04	8	97	2	PF08385
Domain	Dynein_heavy_dom-1	DYNC2H1 DYNC1H1	7.32e-04	8	97	2	IPR013594
Domain	WD40_repeat_dom	DMXL2 WDR64 COPA TLE1 LRBA TAF5 WDR24	9.08e-04	297	97	7	IPR017986
Domain	AAA+_ATPase	DYNC2H1 PSMC1 ATAD2 MDN1 DYNC1H1	9.27e-04	144	97	5	IPR003593
Domain	AAA	DYNC2H1 PSMC1 ATAD2 MDN1 DYNC1H1	9.27e-04	144	97	5	SM00382
Domain	Prot_kinase_dom	FLT1 RPS6KA5 STK17A PDPK1 TSSK2 RET PRKCA TSSK1B MAP4K4	9.99e-04	489	97	9	IPR000719
Domain	PROTEIN_KINASE_DOM	FLT1 RPS6KA5 STK17A PDPK1 TSSK2 RET PRKCA TSSK1B MAP4K4	1.06e-03	493	97	9	PS50011
Domain	MIR	RYR3 ITPR1	1.17e-03	10	97	2	PS50919
Domain	MIR	RYR3 ITPR1	1.17e-03	10	97	2	PF02815
Domain	MIR	RYR3 ITPR1	1.17e-03	10	97	2	SM00472
Domain	ALDOKETO_REDUCTASE_1	AKR1B10 AKR1B15	1.17e-03	10	97	2	PS00798
Domain	Aldo/ket_reductase_CS	AKR1B10 AKR1B15	1.17e-03	10	97	2	IPR018170
Domain	Aldo/keto_reductase	AKR1B10 AKR1B15	1.17e-03	10	97	2	IPR020471
Domain	MIR_motif	RYR3 ITPR1	1.17e-03	10	97	2	IPR016093
Domain	ALDOKETO_REDUCTASE_2	AKR1B10 AKR1B15	1.17e-03	10	97	2	PS00062
Domain	ALDOKETO_REDUCTASE_3	AKR1B10 AKR1B15	1.17e-03	10	97	2	PS00063
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DYNC1H1	2.33e-03	14	97	2	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DYNC1H1	2.33e-03	14	97	2	IPR024743
Domain	Dynein_heavy_dom-2	DYNC2H1 DYNC1H1	2.33e-03	14	97	2	IPR013602
Domain	DHC_N2	DYNC2H1 DYNC1H1	2.33e-03	14	97	2	PF08393
Domain	MT	DYNC2H1 DYNC1H1	2.33e-03	14	97	2	PF12777
Domain	AAA_8	DYNC2H1 DYNC1H1	2.33e-03	14	97	2	PF12780
Domain	Ser/Thr_kinase_AS	RPS6KA5 STK17A PDPK1 TSSK2 PRKCA TSSK1B MAP4K4	2.59e-03	357	97	7	IPR008271
Domain	S_TKc	RPS6KA5 STK17A PDPK1 TSSK2 PRKCA TSSK1B MAP4K4	2.67e-03	359	97	7	SM00220
Domain	DHC_fam	DYNC2H1 DYNC1H1	2.68e-03	15	97	2	IPR026983
Domain	Dynein_heavy_dom	DYNC2H1 DYNC1H1	2.68e-03	15	97	2	IPR004273
Domain	Dynein_heavy	DYNC2H1 DYNC1H1	2.68e-03	15	97	2	PF03028
Domain	PI3/4_kinase_CS	PI4KB ATM	2.68e-03	15	97	2	IPR018936
Domain	PROTEIN_KINASE_ST	RPS6KA5 STK17A PDPK1 TSSK2 PRKCA TSSK1B MAP4K4	2.80e-03	362	97	7	PS00108
Domain	Post-SET_dom	SETD1A SETMAR	3.06e-03	16	97	2	IPR003616
Domain	PostSET	SETD1A SETMAR	3.06e-03	16	97	2	SM00508
Domain	-	PI4KB ATM	3.06e-03	16	97	2	1.10.1070.11
Domain	-	AKR1B10 AKR1B15	3.06e-03	16	97	2	3.20.20.100
Domain	PI3Kc	PI4KB ATM	3.06e-03	16	97	2	SM00146
Domain	POST_SET	SETD1A SETMAR	3.06e-03	16	97	2	PS50868
Domain	NADP_OxRdtase_dom	AKR1B10 AKR1B15	3.45e-03	17	97	2	IPR023210
Domain	Aldo_ket_red	AKR1B10 AKR1B15	3.45e-03	17	97	2	PF00248
Domain	Aldo/ket_red/Kv-b	AKR1B10 AKR1B15	3.45e-03	17	97	2	IPR001395
Domain	Pkinase	RPS6KA5 STK17A PDPK1 TSSK2 PRKCA TSSK1B MAP4K4	3.71e-03	381	97	7	PF00069
Domain	PI3/4_kinase_cat_dom	PI4KB ATM	3.87e-03	18	97	2	IPR000403
Domain	PI3_PI4_kinase	PI4KB ATM	3.87e-03	18	97	2	PF00454
Domain	PI3_4_KINASE_3	PI4KB ATM	3.87e-03	18	97	2	PS50290
Domain	PI3_4_KINASE_1	PI4KB ATM	3.87e-03	18	97	2	PS00915
Domain	PI3_4_KINASE_2	PI4KB ATM	3.87e-03	18	97	2	PS00916
Domain	C2	SMURF1 SYT16 PRKCA SMURF2	4.84e-03	131	97	4	PF00168
Pathway	REACTOME_CROSS_PRESENTATION_OF_PARTICULATE_EXOGENOUS_ANTIGENS_PHAGOSOMES	NCF1 NCF1C NCF1B	1.44e-05	9	80	3	MM14524
Pathway	BIOCARTA_FMLP_PATHWAY	NCF1 NFATC4 NCF1C NCF1B	3.92e-05	34	80	4	MM1399
Pubmed	PKC-alpha mediates flow-stimulated superoxide production in thick ascending limbs.	NCF1 PRKCA NCF1C NCF1B	7.25e-11	4	103	4	20053794
Pubmed	ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion.	NCF1 PLD1 NCF1C NCF1B	2.52e-09	7	103	4	11544318
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SETD1A UBE3B MYOM3 MED14 ELP6 NUP214 CEP192 FANCA MDN1 INF2 ANKRD34A LRBA HERC2 PC SMURF2 DYNC1H1 NOTCH1 WDR24	4.08e-09	1105	103	18	35748872
Pubmed	Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4.	NCF1 NCF1C NCF1B G6PD	1.50e-08	10	103	4	21212270
Pubmed	Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	27044504
Pubmed	NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	18787174
Pubmed	Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	24873968
Pubmed	p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	22184329
Pubmed	Natural Loss-of-Function Mutations in Qa2 and NCF1 Cause the Spread of Mannan-Induced Psoriasis.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	33545139
Pubmed	Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	20142487
Pubmed	p47(phox) contributes to albuminuria and kidney fibrosis in mice.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	25565313
Pubmed	Knockout of neutrophil cytosolic factor 1 ameliorates neuroinflammation and motor deficit after traumatic brain injury.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	39357591
Pubmed	Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	11435342
Pubmed	Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	31118934
Pubmed	Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	16041040
Pubmed	Intermittent hypoxia has organ-specific effects on oxidative stress.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	18703411
Pubmed	Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	17307863
Pubmed	Ncf1 affects osteoclast formation but is not critical for postmenopausal bone loss.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	27829407
Pubmed	The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	22376231
Pubmed	Leishmania amazonensis amastigotes trigger neutrophil activation but resist neutrophil microbicidal mechanisms.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	23918780
Pubmed	NADPH oxidase NOX2 mediates TLR2/6-dependent release of GM-CSF from endothelial cells.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	28274989
Pubmed	Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	12364355
Pubmed	NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	34557202
Pubmed	Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	28467721
Pubmed	P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	10670582
Pubmed	Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	26528554
Pubmed	The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	19052348
Pubmed	Effect of early particulate air pollution exposure on obesity in mice: role of p47phox.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	20864666
Pubmed	Reactive oxygen species delay control of lymphocytic choriomeningitis virus.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	23328631
Pubmed	p47phox-Dependent Oxidant Signalling through ASK1, MKK3/6 and MAPKs in Angiotensin II-Induced Cardiac Hypertrophy and Apoptosis.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	34572995
Pubmed	Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	17114280
Pubmed	B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	25989352
Pubmed	Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	17404617
Pubmed	Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	17332431
Pubmed	Lpp of Escherichia coli K1 inhibits host ROS production to counteract neutrophil-mediated elimination.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	36592568
Pubmed	Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	30504842
Pubmed	Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	33705493
Pubmed	Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	23965970
Pubmed	Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	15513930
Pubmed	Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	15033459
Pubmed	Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	20828610
Pubmed	p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	20817944
Pubmed	NCF1-dependent production of ROS protects against lupus by regulating plasmacytoid dendritic cell development and functions.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	36853827
Pubmed	Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	23024271
Pubmed	Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	21253614
Pubmed	Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	15310853
Pubmed	Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	31393787
Pubmed	Vascular effects following homozygous disruption of p47(phox) : An essential component of NADPH oxidase.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	10725280
Pubmed	Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	34970267
Pubmed	Germ-free mice deficient of reactive oxygen species have increased arthritis susceptibility.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	25689796
Pubmed	Opposing roles of p47phox in basal versus angiotensin II-stimulated alterations in vascular O2- production, vascular tone, and mitogen-activated protein kinase activation.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	14993144
Pubmed	Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	22050439
Pubmed	The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	12031896
Pubmed	NAD(P)H oxidase-derived superoxide mediates hypercholesterolemia-induced leukocyte-endothelial cell adhesion.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	11249873
Pubmed	Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	15936744
Pubmed	NADPH oxidase p47phox siRNA attenuates adventitial fibroblasts proliferation and migration in apoE(-/-) mouse.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	25628043
Pubmed	Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	12560337
Pubmed	Inhibition of endothelial Nox2 activation by LMH001 protects mice from angiotensin II-induced vascular oxidative stress, hypertension and aortic aneurysm.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	35276443
Pubmed	Reactive oxygen species modulate growth of cerebral aneurysms: a study using the free radical scavenger edaravone and p47phox(-/-) mice.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	19381132
Pubmed	Identification of a novel NCF-1 (p47-phox) pseudogene not containing the signature GT deletion: significance for A47 degrees chronic granulomatous disease carrier detection.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	12176908
Pubmed	A p47-phox pseudogene carries the most common mutation causing p47-phox- deficient chronic granulomatous disease.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	9329953
Pubmed	Superoxide prevents nitric oxide-mediated suppression of helper T lymphocytes: decreased autoimmune encephalomyelitis in nicotinamide adenine dinucleotide phosphate oxidase knockout mice.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	10799876
Pubmed	Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alpha.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	11834706
Pubmed	A model of chronic enthesitis and new bone formation characterized by multimodal imaging.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	30045841
Pubmed	Virulence and cellular interactions of Burkholderia multivorans in chronic granulomatous disease.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	19635825
Pubmed	The NCF1 variant p.R90H aggravates autoimmunity by facilitating the activation of plasmacytoid dendritic cells.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	35788118
Pubmed	Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	17310103
Pubmed	Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	18036262
Pubmed	Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	10678931
Pubmed	Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	17167081
Pubmed	Mice lacking NCF1 exhibit reduced growth of implanted melanoma and carcinoma tumors.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	24358335
Pubmed	Molecular characterization of the mouse p47-phox (Ncf1) gene and comparative analysis of the mouse p47-phox (Ncf1) gene to the human NCF1 gene.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	10891396
Pubmed	P47phox-/- mice are compromised in expansion and activation of CD8+ T cells and susceptible to Trypanosoma cruzi infection.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	25474113
Pubmed	NAD(P)H oxidase subunit p47phox is elevated, and p47phox knockout prevents diaphragm contractile dysfunction in heart failure.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	26209274
Pubmed	NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	11018074
Pubmed	Enhanced host defense after gene transfer in the murine p47phox-deficient model of chronic granulomatous disease.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	9116268
Pubmed	Mice producing less reactive oxygen species are relatively resistant to collagen glycopeptide vaccination against arthritis.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	20686129
Pubmed	Angiotensin II induced catabolic effect and muscle atrophy are redox dependent.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	21570954
Pubmed	Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	12958309
Pubmed	Female mice lacking p47phox have altered adipose tissue gene expression and are protected against high fat-induced obesity.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	23482812
Pubmed	The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	10085000
Pubmed	Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	10987289
Pubmed	Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	21435178
Pubmed	Mycobacterial infection induces higher interleukin-1β and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	29228045
Pubmed	Generation of reactive oxygen species (ROS) is a key factor for stimulation of macrophage proliferation by ceramide 1-phosphate.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	22155727
Pubmed	Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	24576409
Pubmed	The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	26645958
Pubmed	NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	24549323
Pubmed	NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	20881184
Pubmed	Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	19168575
Pubmed	NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	19503084
Pubmed	Genetic requirement of p47phox for superoxide production by murine microglia.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	11156938
Pubmed	Genomic structure of the human p47-phox (NCF1) gene.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	10772875
Pubmed	A Feed-Forward Mechanism Involving the NOX Complex and RyR-Mediated Ca2+ Release During Axonal Specification.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	27798190
Pubmed	Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived reactive oxygen species.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	20702812
Pubmed	Macrophage-derived reactive oxygen species protects against autoimmune priming with a defined polymeric adjuvant.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	26455429
Pubmed	Conditional haploinsufficiency of NCF1 (encoding p47(phox)), a signaling gene with a heterozygous phenotype potentially subject to natural selection.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	15626477
Pubmed	NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	19077231
Pubmed	Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	22319452
Pubmed	Early determinants of H2O2-induced endothelial dysfunction.	NCF1 NCF1C NCF1B	2.52e-08	3	103	3	16895801
Interaction	YWHAZ interactions	HDAC9 DMXL2 RPS6KA5 PDPK1 SPTA1 RALGAPB TACC2 CEP192 ITPR1 VPS13D NFATC4 SULT1C3 PI4KB KCTD16 ANKRD34A PRKCA ATM HERC2 CDC25A G6PD DYNC1H1	1.62e-06	1319	100	21	int:YWHAZ
Interaction	YWHAQ interactions	MYH7 PDPK1 SPTA1 NCF1 SMURF1 CEP192 CEP350 VPS13D RNH1 NFATC4 PI4KB DENND2C PRKCA LRBA CDC25A PC G6PD DYNC1H1	8.74e-06	1118	100	18	int:YWHAQ
Interaction	TP53BP1 interactions	SETD1A SETX ACD RPS6KA5 MED14 PSMC1 SLC35D1 MDN1 ATM HERC2 PSPC1 SMURF2	1.31e-05	533	100	12	int:TP53BP1
GeneFamily	WD repeat domain containing	DMXL2 WDR64 COPA TLE1 LRBA TAF5 WDR24	6.82e-05	262	70	7	362
GeneFamily	Dyneins, cytoplasmic	DYNC2H1 DYNC1H1	1.12e-03	13	70	2	538
GeneFamily	AAA ATPases	PSMC1 ATAD2 MDN1	1.13e-03	53	70	3	413
GeneFamily	Aldo-keto reductases	AKR1B10 AKR1B15	1.50e-03	15	70	2	399
GeneFamily	Cadherin related	CDHR5 RET	1.94e-03	17	70	2	24
Coexpression	GSE360_L_DONOVANI_VS_M_TUBERCULOSIS_DC_DN	HTRA1 SETX SPTA1 MED14 PSMC1 PPARD SLC35D1	1.40e-05	199	103	7	M5206
Coexpression	GSE29618_PRE_VS_DAY7_POST_LAIV_FLU_VACCINE_BCELL_DN	UBE3B TSSK2 CDHR5 VANGL1 ATM QTRT1 TAF1D	1.40e-05	199	103	7	M4984
Coexpression	HADDAD_B_LYMPHOCYTE_PROGENITOR	NEIL1 SPTA1 ITPR1 SLC35D1 TLE1 ATM PSPC1 MAP4K4	1.95e-05	290	103	8	M939
Coexpression	PILON_KLF1_TARGETS_UP	FLT1 ZNF562 CYP2D7 SPTA1 RALGAPB MIER1 AKR1B10 DENND2C AKR1B15 TENT2	5.47e-05	541	103	10	MM1061
Coexpression	GSE29618_BCELL_VS_MDC_UP	STK17A ITPR1 TLE1 NCF1C MAP4K4 TAF1D	1.20e-04	194	103	6	M4943
Coexpression	GSE10325_LUPUS_BCELL_VS_LUPUS_MYELOID_UP	STK17A DIPK1A BCL11A MDN1 TLE1 LRBA	1.23e-04	195	103	6	M3089
Coexpression	GSE17974_0.5H_VS_72H_IL4_AND_ANTI_IL12_ACT_CD4_TCELL_UP	SETMAR STK17A SMURF1 NUP214 SLC35D1 NOTCH1	1.27e-04	196	103	6	M4244
Coexpression	GAVIN_PDE3B_TARGETS	NCF1 NCF1C NCF1B	1.27e-04	25	103	3	MM726
Coexpression	GSE16450_CTRL_VS_IFNA_12H_STIM_IMMATURE_NEURON_CELL_LINE_UP	RTN4IP1 VPS13D MDN1 PRKCA LRBA HERC2	1.30e-04	197	103	6	M7403
Coexpression	GSE40184_HEALTHY_VS_HCV_INFECTED_DONOR_PBMC_UP	NEIL1 DIPK1A GRM4 MDN1 RRN3 ZFP41	1.38e-04	199	103	6	M9405
Coexpression	GSE10273_HIGH_VS_LOW_IL7_TREATED_IRF4_8_NULL_PRE_BCELL_DN	SETX SMURF1 VPS13D HERC2 SMURF2 DYNC1H1	1.38e-04	199	103	6	M316
Coexpression	GSE40277_EOS_AND_LEF1_TRANSDUCED_VS_GATA1_AND_SATB1_TRANSDUCED_CD4_TCELL_DN	DIPK1A TACC2 ITPR1 DENND2C ENTPD5 ATM	1.38e-04	199	103	6	M9170
Coexpression	GSE2770_IL12_VS_IL4_TREATED_ACT_CD4_TCELL_48H_DN	SETD1A SETX DIPK1A RALGAPB SMURF1 ENTPD5	1.38e-04	199	103	6	M6030
Coexpression	GSE8621_UNSTIM_VS_LPS_PRIMED_AND_LPS_STIM_MACROPHAGE_DN	HDAC9 DYNC2H1 PPARD ITPR1 PRKCA NOTCH1	1.38e-04	199	103	6	M6987
Coexpression	GSE39556_UNTREATED_VS_3H_POLYIC_INJ_MOUSE_CD8A_DC_DN	DMXL2 SPTA1 BCL11A ITPR1 TLE1 MAP4K4	1.42e-04	200	103	6	M9408
Coexpression	GSE5503_MLN_DC_VS_PLN_DC_ACTIVATED_ALLOGENIC_TCELL_DN	DYNC2H1 PPARD ITPR1 TLE1 PRKCA NOTCH1	1.42e-04	200	103	6	M291
Coexpression	GSE10273_LOW_IL7_VS_HIGH_IL7_AND_IRF4_IN_IRF4_8_NULL_PRE_BCELL_DN	FLT1 RPS6KA5 TACC2 VPS13D G6PD SMURF2	1.42e-04	200	103	6	M322
Coexpression	GSE5679_CTRL_VS_PPARG_LIGAND_ROSIGLITAZONE_TREATED_DC_DN	HDAC9 NEIL1 RYR3 SLC35D1 ARHGAP5 PRKCA	1.42e-04	200	103	6	M6554
Coexpression	CALVET_IRINOTECAN_SENSITIVE_VS_RESISTANT_UP	FLT1 ATM	1.52e-04	5	103	2	M17456
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	SETX ERCC5 NCF1 SLC26A5 MED14 CEP192 BCL11A ATAD2 CEP350 ARHGAP5 MDN1 TLE1 PI4KB ZFP41 ATM TAF5 PSPC1 SLC27A4 TAF1D	8.69e-06	1257	103	19	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_k-means-cluster#2_top-relative-expression-ranked_1000	RPS6KA5 RTN4IP1 CEP192 ATAD2 MDN1 DENND2C ATM TAF5	4.65e-05	266	103	8	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_k2_1000
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500	SETX ERCC5 NCF1 SLC26A5 MED14 CEP192 BCL11A ATAD2 CEP350 ARHGAP5 MDN1 TLE1 PI4KB ZFP41 ATM TAF5 PSPC1 SLC27A4 TAF1D	6.78e-05	1459	103	19	facebase_RNAseq_e10.5_Emin_LatNas_2500
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_B-B_cells-B-cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HDAC9 DIPK1A NCF1 BCL11A GRM4 ITPR1	2.63e-06	168	103	6	eeb381b62c7ba263af96de1194ed59e57b6ca3ae
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_B-B_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HDAC9 DIPK1A NCF1 BCL11A GRM4 ITPR1	2.63e-06	168	103	6	063d0368d656962b335154c230bdcd9236e7c9ad
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_B\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HDAC9 DIPK1A NCF1 BCL11A GRM4 ITPR1	2.63e-06	168	103	6	a7c4251d8a83bc30196a444028a35c17c24dc291
ToppCell	LPS-IL1RA-Lymphocytic_B-B_cells-B-cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HDAC9 DIPK1A NCF1 BCL11A GRM4 ITPR1	2.81e-06	170	103	6	92e0873f618b2fa60c4d555b10f234d5cbcf3325
ToppCell	LPS-IL1RA-Lymphocytic_B-B_cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HDAC9 DIPK1A NCF1 BCL11A GRM4 ITPR1	2.81e-06	170	103	6	c181991f933b779f99afc3782f292306f209e2ac
ToppCell	LPS-IL1RA-Lymphocytic_B\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HDAC9 DIPK1A NCF1 BCL11A GRM4 ITPR1	2.81e-06	170	103	6	56284fbfd1e53f67c8c0b7fba64505a4002adba2
ToppCell	LPS-antiTNF-Lymphocytic_B\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HDAC9 DIPK1A NCF1 BCL11A GRM4 ITPR1	3.22e-06	174	103	6	cc493654ea3517bc6a145c7f787f304929636f86
ToppCell	LPS-antiTNF-Lymphocytic_B-B_cells-B-cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HDAC9 DIPK1A NCF1 BCL11A GRM4 ITPR1	3.22e-06	174	103	6	9eb3504f9340517ef5d056503044fbdb9ffeb714
ToppCell	LPS-antiTNF-Lymphocytic_B-B_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HDAC9 DIPK1A NCF1 BCL11A GRM4 ITPR1	3.22e-06	174	103	6	b4c2d1c029fcd0d4926aa79a5b789c713919dcf3
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B-B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HDAC9 STK17A BCL11A ITPR1 ATM MAP4K4	4.04e-06	181	103	6	8d8cc4dae2c8bd5f4b1c159f2a52edc4c9449c86
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_activate-7\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HDAC9 NEIL1 NCF1 BCL11A TLE1 TAF1D	5.17e-06	189	103	6	ef33cc03728a78423ee92d2ef1ffed4918d4221f
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HDAC9 FLT1 BCL11A ITPR1 TLE1 NCF1C	5.17e-06	189	103	6	e2bb5900d210386b7b74938e7a3636d0c7ba1bcf
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NCF1 BCL11A ITPR1 NCF1C MAP4K4 NCF1B	6.01e-06	194	103	6	ff661419b697aef51a53fdeac8d37d870d65f491
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BCL11A GRM4 GSDMC AKR1B10 DENND2C PLD1	6.95e-06	199	103	6	f5c3561744e2a0e7716657cb521acb1d8f054b41
ToppCell	5'-Adult-Appendix-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL11A FANCA KCTD16 ATM MAP4K4	3.13e-05	156	103	5	203ef22eb76bd2b829b027c30af0557080f4006c
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	HDAC9 NCF1 BCL11A ITPR1 TLE1	3.86e-05	163	103	5	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	HDAC9 NCF1 BCL11A ITPR1 TLE1	5.12e-05	173	103	5	d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Enterocyte\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDHR5 MIER1 SLC35D1 ARHGAP5 ENTPD5	5.26e-05	174	103	5	2fbdb62e269acf4447b171700a615e878dde7f9f
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDHR5 MIER1 SLC35D1 ARHGAP5 ENTPD5	5.26e-05	174	103	5	7c52b5d8f1e65e5208c952be341fa155ed0e6e76
ToppCell	Control-B_cells-B_cells\|Control / group, cell type (main and fine annotations)	HDAC9 NCF1 BCL11A ITPR1 ATM	5.56e-05	176	103	5	d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCell	LPS_only-Lymphocytic_B-B_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HDAC9 NCF1 BCL11A GRM4 ITPR1	5.71e-05	177	103	5	c82332c5f656aa26513e4f7525d5d4d733019725
ToppCell	LPS_only-Lymphocytic_B\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HDAC9 NCF1 BCL11A GRM4 ITPR1	5.71e-05	177	103	5	5ed65e08d773d157840317c72e0d43c261d438d4
ToppCell	LPS_only-Lymphocytic_B-B_cells-B-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HDAC9 NCF1 BCL11A GRM4 ITPR1	5.71e-05	177	103	5	8a955a7ab84c434f9ad4b467246b8be3cb479406
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	VPS13D MDN1 PRKCA PC DYNC1H1	5.71e-05	177	103	5	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-2\|TCGA-Skin / Sample_Type by Project: Shred V9	RPS6KA5 VANGL1 PLD1 LRBA DYNC1H1	6.34e-05	181	103	5	9d5b331cabc5524f0a9fd8b571e87be4c447c7d4
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH7 BCL11A GRM4 RYR3 KCTD16	6.51e-05	182	103	5	d41ff834b8fc1d0e23cac7ae261de5f72874e462
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH7 BCL11A GRM4 RYR3 KCTD16	6.51e-05	182	103	5	6cde859edfe7607bd7ada89d20258413d06f4207
ToppCell	remission-B_naive\|remission / disease stage, cell group and cell class	HDAC9 FLT1 NCF1 BCL11A TLE1	6.68e-05	183	103	5	280d55d67f1d44594206da2f3a332c9d799dbdf0
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HDAC9 RET GRM4 RYR3 PLD1	6.86e-05	184	103	5	658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCell	10x5'-GI_large-bowel-Lymphocytic_B-Naive_B_cells\|GI_large-bowel / Manually curated celltypes from each tissue	NCF1 BCL11A ITPR1 TLE1 MAP4K4	7.04e-05	185	103	5	1c99373c123b5e0de40b47d9d885974a747b9839
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	HDAC9 MYH7 MYOM3 TACC2 BCL11A	7.04e-05	185	103	5	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	Children_(3_yrs)-Immune-B_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HDAC9 DIPK1A NCF1 BCL11A ITPR1	7.22e-05	186	103	5	aa576748921a318798b911a611f05319b95e8d5e
ToppCell	lymphoid-B_cell-Naive_B_cell\|World / Lineage, cell class and subclass	HDAC9 NEIL1 NCF1 BCL11A TLE1	7.40e-05	187	103	5	904ffd8cf4513e86fcd4c2b7faf24a34fbd2dce3
ToppCell	lymphoid-B_cell\|World / Lineage, cell class and subclass	HDAC9 NEIL1 NCF1 BCL11A TLE1	7.40e-05	187	103	5	2abbc01fd7f5b4e52113699625287893c991f8da
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NEIL1 STK17A BCL11A ITPR1 TLE1	7.59e-05	188	103	5	d8decd9b5967873ca8320c2f9f07365f163c777f
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	HDAC9 MYH7 MYOM3 TACC2 BCL11A	7.59e-05	188	103	5	0758b474457efa36488e0195f7357100f4b6a090
ToppCell	10x5'-blood-Lymphocytic_B-Naive_B_cells\|blood / Manually curated celltypes from each tissue	HDAC9 NCF1 BCL11A ITPR1 TLE1	7.59e-05	188	103	5	2b3560b28f9df6f4d4a3e0a4acfa6c7d964ad0fe
ToppCell	356C-Lymphocytic-B_cell\|356C / Donor, Lineage, Cell class and subclass (all cells)	STK17A NCF1 BCL11A TLE1 TAF1D	7.78e-05	189	103	5	5168038d098ed59f042059a9f82496ddadf98e8f
ToppCell	356C-Lymphocytic-B_cell-\|356C / Donor, Lineage, Cell class and subclass (all cells)	STK17A NCF1 BCL11A TLE1 TAF1D	7.78e-05	189	103	5	4aea4c86ba3641e34952bb3954a26655cff314b9
ToppCell	lymphoid-B_cell-Naive_B_cell\|lymphoid / Lineage, cell class and subclass	HDAC9 NEIL1 NCF1 BCL11A TLE1	7.98e-05	190	103	5	b8b05894e811e431d797ac4fa3ccff4963a154e7
ToppCell	lymphoid-B_cell\|lymphoid / Lineage, cell class and subclass	HDAC9 NEIL1 NCF1 BCL11A TLE1	7.98e-05	190	103	5	c451de643ee08c2ff1093e807c65d724237473c5
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HDAC9 RET GRM4 KCTD16 PRKCA	7.98e-05	190	103	5	1bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	HDAC9 RALGAPB BCL11A ITPR1 TLE1	8.59e-05	193	103	5	08696a99309f5b088692ddac8cca35413b5e810d
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-9\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NEIL1 NCF1 BCL11A TLE1 TAF1D	8.59e-05	193	103	5	d5d188a314da1b4c8390276d88173c09dd7ce4bf
ToppCell	severe_influenza-B_naive\|severe_influenza / disease group, cell group and cell class (v2)	NEIL1 STK17A BCL11A TLE1 TAF1D	8.80e-05	194	103	5	7c1e9ce5de3bb1657a67010de673c8bb60129cb6
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NEIL1 NCF1 BCL11A TLE1 TAF1D	8.80e-05	194	103	5	24f9de4781666c96c4a2d04f8a444543dbd99cbe
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-B_cell\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HDAC9 BCL11A ITPR1 TLE1 TAF1D	8.80e-05	194	103	5	87604c93d20f9171e0a1279bdb6ad73fe5fed356
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NEIL1 BCL11A ITPR1 TLE1 TAF1D	8.80e-05	194	103	5	36ce99b9e4e1c968cc7ae381168124cc7c14afb2
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NEIL1 NCF1 BCL11A ITPR1 TLE1	8.80e-05	194	103	5	287439c51528d7bb13bd235875d85631dc91ed91
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	NEIL1 NCF1 BCL11A ITPR1 TLE1	9.01e-05	195	103	5	b74645072a063732d5be43036ce0e9568eff3d14
ToppCell	Influenza_Severe-B_naive\|Influenza_Severe / Disease group and Cell class	NEIL1 STK17A BCL11A TLE1 TAF1D	9.01e-05	195	103	5	a25516ed670c7738670ffbaa6f7cd167946f3825
ToppCell	myeloid-Monocyte-CD14+_Monocyte\|myeloid / Lineage, cell class and subclass	DMXL2 NCF1 NUP214 PLD1 NOTCH1	9.01e-05	195	103	5	15ba9c5f6ecb6ae2c603e6b036eb92b00b46f13f
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNC2H1 RET PRKCA PC DYNC1H1	9.01e-05	195	103	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NEIL1 NCF1 BCL11A ITPR1 TLE1	9.01e-05	195	103	5	4b882a71f0e02fef5580e9d9bc42245cf9df2e57
ToppCell	mild_COVID-19_(asymptomatic)-B_naive\|World / disease group, cell group and cell class (v2)	NEIL1 BCL11A ITPR1 TLE1 TAF1D	9.01e-05	195	103	5	e763d9a431052c03cc6d514f2736506c6667e2be
ToppCell	severe_COVID-19-B_naive\|World / disease group, cell group and cell class (v2)	NEIL1 BCL11A ITPR1 TLE1 TAF1D	9.01e-05	195	103	5	e6c77119494b787c44502c0390fb2c86a34b1846
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNC2H1 RET PRKCA PC DYNC1H1	9.01e-05	195	103	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	COVID-19_Severe-Lymphoid_B-B_naive\|COVID-19_Severe / Disease group, lineage and cell class	NEIL1 BCL11A ITPR1 TLE1 TAF1D	9.01e-05	195	103	5	71563e838fcda34a9a209c5433e0d84420373402
ToppCell	mild_COVID-19_(asymptomatic)-B_naive\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	NEIL1 BCL11A ITPR1 TLE1 TAF1D	9.23e-05	196	103	5	c87499aa570f8fab878c4c015e47c711a3a21e9c
ToppCell	mild_COVID-19-B_naive\|mild_COVID-19 / disease group, cell group and cell class (v2)	NEIL1 NCF1 BCL11A ITPR1 TLE1	9.23e-05	196	103	5	00398079d3ac14dc2026c0cbd7388f1f3257b134
ToppCell	Healthy/Control-B_naive\|Healthy/Control / Disease group and Cell class	NEIL1 NCF1 BCL11A ITPR1 TLE1	9.23e-05	196	103	5	e92d2c814d2dcb049f3e455fe66fd40898b3524d
ToppCell	Healthy_donor-B_naive\|Healthy_donor / disease group, cell group and cell class (v2)	NEIL1 NCF1 BCL11A ITPR1 TLE1	9.23e-05	196	103	5	cf254b1466357984201595fa32408d659eb741ef
ToppCell	COVID-19_Mild-Lymphoid_B-B_naive\|COVID-19_Mild / Disease group, lineage and cell class	NEIL1 NCF1 BCL11A ITPR1 TLE1	9.23e-05	196	103	5	4b3ceb1f85be0fa8d53dc5548326ab0a5239a8b9
ToppCell	severe_COVID-19-B_naive\|severe_COVID-19 / disease group, cell group and cell class (v2)	NEIL1 BCL11A ITPR1 TLE1 TAF1D	9.23e-05	196	103	5	1a2b7c3f00098e9b4c0659b8714a0e4cf9f86f27
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NCF1 BCL11A ITPR1 NCF1C NCF1B	9.46e-05	197	103	5	fa3cc33c975648172feabb485c3bdd087f1f8ea7
ToppCell	proximal-Hematologic-B_cell\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	STK17A NCF1 BCL11A NCF1C NCF1B	9.46e-05	197	103	5	735b5026d28cd3677947ae8e462f6fd640cf9c9b
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HDAC9 DIPK1A NCF1 BCL11A ITPR1	9.46e-05	197	103	5	da61afba697ec49ca86e062d35a825280da558ac
ToppCell	URO-Myeloid-cDC2\|URO / Disease, Lineage and Cell Type	HDAC9 ATP5PF BCL11A ARHGAP5 RNH1	9.46e-05	197	103	5	7fee14356d7fba68a0515c8b9284568d14124b0a
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HDAC9 WDR64 DIPK1A NCF1 BCL11A	9.46e-05	197	103	5	0f489d26e4013d1b5a90559856ed2de32a0bb772
ToppCell	proximal-Hematologic-B_cell-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	STK17A NCF1 BCL11A NCF1C NCF1B	9.46e-05	197	103	5	08b3f2e3933242b9fa93998cfce3d094a3db833e
ToppCell	proximal-3-Hematologic-B_cell\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	STK17A NCF1 BCL11A NCF1C NCF1B	9.46e-05	197	103	5	81ba0eb2222e83b4ba2db3228dc04c390c2dbc63
ToppCell	mild_COVID-19-B_naive\|World / disease group, cell group and cell class (v2)	NEIL1 BCL11A ITPR1 TLE1 TAF1D	9.46e-05	197	103	5	b817ecdcea453a15fd0dd1d7fdf196bed68f7358
ToppCell	Control-PLT_4\|Control / Disease Group and Platelet Clusters	SETX STK17A MIER1 VANGL1 DENND2C	9.69e-05	198	103	5	387fd3037fd52e4d4c42de0588767e58af228b59
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-B-B_naive\|COVID-19_Mild / Disease, condition lineage and cell class	NEIL1 NCF1 BCL11A ITPR1 TLE1	1.02e-04	200	103	5	e6a43eff47195e1d39530ad49ad908fc06a8b038
ToppCell	MS-IIF-Lymphocyte-B-B_naive\|IIF / Disease, condition lineage and cell class	HDAC9 NCF1 BCL11A ITPR1 TLE1	1.02e-04	200	103	5	15f429137b2a3906724118085fcd59750cd767c7
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-B-B_naive\|COVID-19_Severe / Disease, condition lineage and cell class	NEIL1 BCL11A ITPR1 TLE1 TAF1D	1.02e-04	200	103	5	5ba9c541fa356d34f392a63274dcd7bfb844cbb6
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-GLP2R--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	WDR64 ITPR1 TLE1 KCTD16 PRKCA	1.02e-04	200	103	5	dc8702e3cb4ac8c1a9849fc8abf8777f12d55b0b
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-B-B_naive\|Multiple_Sclerosis / Disease, condition lineage and cell class	HDAC9 STK17A NCF1 BCL11A TLE1	1.02e-04	200	103	5	4d16545608aa4289a5e406512100c617ccee6a97
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-GLP2R---L2-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	WDR64 ITPR1 TLE1 KCTD16 PRKCA	1.02e-04	200	103	5	d92d51021ab6d78e9c8f89f7c150181004dcbcbd
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-GLP2R-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	WDR64 ITPR1 TLE1 KCTD16 PRKCA	1.02e-04	200	103	5	cbbb9044283ff9ab63bbfc24d7a9f006b1372705
ToppCell	Influenza-Influenza_Severe-Lymphocyte-B-B_naive\|Influenza_Severe / Disease, condition lineage and cell class	NEIL1 STK17A BCL11A TLE1 TAF1D	1.02e-04	200	103	5	0e05600d725dc5cc9afccc11eedc60efa41e4e46
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SETX CEP350 APOL6 ATM DYNC1H1	1.02e-04	200	103	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	severe-B_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NEIL1 BCL11A ITPR1 TLE1 TAF1D	1.02e-04	200	103	5	0e86f52b6e146d9bbc728d8fb176fc2b53696558
ToppCell	COVID-19-COVID-19_Convalescent-Lymphocyte-B-B_naive\|COVID-19_Convalescent / Disease, condition lineage and cell class	HDAC9 FLT1 NCF1 BCL11A TLE1	1.02e-04	200	103	5	5c1b51b9571681d8b792d1443d9f8926dcd55b29
ToppCell	mild-B_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HDAC9 NEIL1 BCL11A ITPR1 TLE1	1.02e-04	200	103	5	222789b897e2a683bbfd1d00b6fd8705015d90df
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-GLP2R\|Neuronal / cells hierarchy compared to all cells using T-Statistic	WDR64 ITPR1 TLE1 KCTD16 PRKCA	1.02e-04	200	103	5	a3e36bbeed19431d07bc205f14f4e0f12bd8f730
ToppCell	Influenza-Influenza_Severe-Lymphocyte-B\|Influenza_Severe / Disease, condition lineage and cell class	NEIL1 STK17A BCL11A TLE1 TAF1D	1.02e-04	200	103	5	bf238a0a074d6c5cba8cb73d3b715ee701a612b6
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	HTRA1 ACD MYOM3 RTN4IP1	1.63e-04	118	103	4	7e6cb77fa9154f2da985c455bb6a24d6029cc8d6
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC26A5 CDHR5 RYR3 PC	2.22e-04	128	103	4	2cf0384240a4a663869cf6b27d954236f6214a9a
Drug	Indomethacin [53-86-1]; Up 200; 11.2uM; MCF7; HT_HG-U133A	DMXL2 DYNC2H1 SMURF1 GSTA3 ITPR1 VPS13D DNAH17 CDC25A	2.87e-06	196	102	8	7409_UP
Drug	Chrysene-1,4-quinone [100900-16-1]; Down 200; 15.4uM; PC3; HT_HG-U133A	SETX RALGAPB ITPR1 SLC35D1 VANGL1 PI4KB ATM TAF1D	2.87e-06	196	102	8	7139_DN
Drug	LY294002	FLT1 MYH7 RPS6KA5 PDPK1 RET GSTA3 ITPR1 PI4KB AKR1B10 PRKCA ATM PLD1 LRBA CDC25A	6.20e-06	748	102	14	CID000003973
Drug	phosphine oxide	SETX GRM4 RYR3 PRKCA LRBA PC	8.74e-06	107	102	6	CID000166931
Drug	NSC226080	FLT1 MYH7 RPS6KA5 PDPK1 NUP214 PPARD RYR3 ITPR1 RRN3 PI4KB PRKCA ATM PLD1 CDC25A	1.02e-05	782	102	14	CID000005040
Drug	Camptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; PC3; HT_HG-U133A	SETX STK17A TACC2 CEP350 VANGL1 TLE1 TAF5	1.69e-05	180	102	7	4541_DN
Drug	0179445-0000 [211246-22-9]; Down 200; 10uM; MCF7; HT_HG-U133A	SETX DIPK1A TACC2 CEP350 VANGL1 TAF5 CDC25A	1.81e-05	182	102	7	3630_DN
Drug	GW8510; Down 200; 10uM; MCF7; HT_HG-U133A	SETX STK17A TACC2 CEP350 VANGL1 TAF5 CDC25A	1.88e-05	183	102	7	7062_DN
Drug	tyrphostin AG-825; Down 200; 25.2uM; MCF7; HT_HG-U133A_EA	SETX CEP350 MDN1 VANGL1 TAF5 CDC25A SMURF2	2.01e-05	185	102	7	1114_DN
Drug	geldanamycin; Up 200; 1uM; MCF7; HG-U133A	SETX SMURF1 TACC2 PPARD ARHGAP5 RRN3 TLE1	2.31e-05	189	102	7	611_UP
Drug	Cefsulodin sodium salt [52152-93-9]; Down 200; 7.2uM; PC3; HT_HG-U133A	SETD1A UBE3B SMURF1 BCL11A ITPR1 DNAH17 NOTCH1	2.64e-05	193	102	7	4067_DN
Drug	phentolamine; Down 200; 11.5uM; MCF7; HT_HG-U133A_EA	PDPK1 MED14 TACC2 NUP214 VPS13D PI4KB PRKCA	2.82e-05	195	102	7	1138_DN
Drug	Perhexiline maleate [6724-53-4]; Down 200; 10.2uM; HL60; HT_HG-U133A	STK17A BCL11A RET FANCA SLC35D1 VPS13D CDC25A	2.82e-05	195	102	7	2410_DN
Drug	Chlormezanone [80-77-3]; Down 200; 14.6uM; HL60; HG-U133A	MED14 ITPR1 FANCA ATM LRBA CDC25A NOTCH1	2.91e-05	196	102	7	1620_DN
Drug	Triflusal [322-79-2]; Down 200; 16.2uM; HL60; HG-U133A	STK17A RET FANCA VPS13D RRN3 PI4KB DYNC1H1	3.01e-05	197	102	7	1717_DN
Drug	Gossypol [303-45-7]; Down 200; 7.8uM; MCF7; HT_HG-U133A	SETD1A DMXL2 RET SLC35D1 VPS13D TLE1 CDC25A	3.11e-05	198	102	7	4762_DN
Drug	Dihydrostreptomycin sulfate [5490-27-7]; Up 200; 2.8uM; HL60; HG-U133A	RPS6KA5 DYNC2H1 MED14 RET VPS13D PLD1 NOTCH1	3.11e-05	198	102	7	1391_UP
Drug	Cloxacillin sodium salt [642-78-4]; Down 200; 8.8uM; HL60; HG-U133A	RPS6KA5 UBE3B SMURF1 PPARD VPS13D PI4KB LRBA	3.11e-05	198	102	7	1443_DN
Drug	Asbestos, Crocidolite	ATP5PF FLT1 SETX DYNC2H1 PDPK1 MED14 PPARD INF2 RRN3 PRKCA PLD1 PC PSPC1 NCF1C G6PD SMURF2 NOTCH1	3.50e-05	1241	102	17	ctd:D017638
Drug	digalloylresveratrol	ATM CDC25A	5.94e-05	3	102	2	ctd:C534866
Disease	chronic granulomatous disease (implicated_via_orthology)	NCF1 NCF1C NCF1B	3.87e-07	5	101	3	DOID:3265 (implicated_via_orthology)
Disease	rheumatoid arthritis (implicated_via_orthology)	NCF1 NCF1C NCF1B	8.37e-06	12	101	3	DOID:7148 (implicated_via_orthology)
Disease	Transitional cell carcinoma of bladder	FLT1 RET	6.93e-05	4	101	2	C0279680
Disease	Malignant Neoplasms	RET AKR1B10 ATM G6PD NOTCH1	8.06e-05	128	101	5	C0006826
Disease	Vasodilators used in cardiac diseases use measurement	HDAC9 FLT1 DYNC2H1	2.16e-04	34	101	3	EFO_0009926
Disease	melanoma	FLT1 ERCC5 RET PPARD AKR1B10 ATM	2.16e-04	248	101	6	C0025202
Disease	Malignant neoplasm of breast	FLT1 DYNC2H1 PDPK1 MED14 TACC2 NUP214 BCL11A ANKRD34A ATM LRBA HERC2 NOTCH1	3.08e-04	1074	101	12	C0006142
Disease	Neoplasm of uncertain or unknown behavior of breast	PDPK1 HERC2 NOTCH1	3.78e-04	41	101	3	C0496956
Disease	Breast adenocarcinoma	PDPK1 HERC2 NOTCH1	3.78e-04	41	101	3	C0858252
Disease	Adenoid Cystic Carcinoma	BCL11A FANCA ATM NOTCH1	3.94e-04	100	101	4	C0010606
Disease	symmetrical dimethylarginine measurement	AKR1B10 AKR1B15	4.11e-04	9	101	2	EFO_0006523
Disease	dilated cardiomyopathy (is_implicated_in)	MYH7 NFATC4 PRKCA	4.35e-04	43	101	3	DOID:12930 (is_implicated_in)
Disease	Asthma, Occupational	PRKCA HERC2	5.13e-04	10	101	2	C0264423
Disease	factor VIII measurement, coronary artery disease	HDAC9 FLT1 DYNC2H1 UBE3B	6.26e-04	113	101	4	EFO_0001645, EFO_0004630
Disease	retinopathy of prematurity (biomarker_via_orthology)	FLT1 NOTCH1	7.49e-04	12	101	2	DOID:13025 (biomarker_via_orthology)
Disease	hair colour measurement, hair morphology measurement	FANCA HERC2	7.49e-04	12	101	2	EFO_0007821, EFO_0007822
Disease	clonal hematopoiesis mutation measurement	SETD1A ITPR1 HERC2	8.97e-04	55	101	3	EFO_0020949
Disease	Malignant neoplasm of skin	FLT1 PPARD NOTCH1	1.10e-03	59	101	3	C0007114
Disease	Skin Neoplasms	FLT1 PPARD NOTCH1	1.10e-03	59	101	3	C0037286
Disease	Neoplasm of uncertain or unknown behavior of bladder	ATM NOTCH1	1.18e-03	15	101	2	C0496930
Disease	African Burkitt's lymphoma	RET PC	1.18e-03	15	101	2	C0343640
Disease	Benign neoplasm of bladder	ATM NOTCH1	1.18e-03	15	101	2	C0154017
Disease	Carcinoma in situ of bladder	ATM NOTCH1	1.18e-03	15	101	2	C0154091
Disease	Burkitt Leukemia	RET PC	1.18e-03	15	101	2	C4721444
Disease	lifestyle measurement, anxiety disorder measurement	WDR64 GSTA3 LRBA CDC25A	1.28e-03	137	101	4	EFO_0007795, EFO_0010724
Disease	coronary artery disease, plasminogen activator inhibitor 1 measurement	HDAC9 FLT1 DYNC2H1	1.33e-03	63	101	3	EFO_0001645, EFO_0004792
Disease	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	ATM NOTCH1	1.35e-03	16	101	2	C0334634
Disease	Kuhnt-Junius degeneration (is_implicated_in)	FLT1 HTRA1	1.53e-03	17	101	2	DOID:10873 (is_implicated_in)
Disease	Carcinoma of bladder	ATM NOTCH1	1.71e-03	18	101	2	C0699885
Disease	tissue plasminogen activator measurement, coronary artery disease	HDAC9 FLT1 DYNC2H1	1.88e-03	71	101	3	EFO_0001645, EFO_0004791
Disease	skin sensitivity to sun	FANCA HERC2	1.91e-03	19	101	2	EFO_0004795
Disease	Adenocarcinoma of prostate	FANCA ATM	2.12e-03	20	101	2	C0007112
Disease	cancer (implicated_via_orthology)	FLT1 RET ATM PIPSL NOTCH1	2.32e-03	268	101	5	DOID:162 (implicated_via_orthology)
Disease	Disproportionate short stature	EVC2 DYNC2H1 SLC35D1	2.37e-03	77	101	3	C0878659
Disease	Breast Carcinoma	FLT1 DYNC2H1 PDPK1 ANKRD34A ATM HERC2 NOTCH1	2.54e-03	538	101	7	C0678222
Disease	lung non-small cell carcinoma (is_marker_for)	HTRA1 PDPK1 BCL11A ATM	2.75e-03	169	101	4	DOID:3908 (is_marker_for)
Disease	Cardiomegaly	PPARD PRKCA PLD1	2.83e-03	82	101	3	C0018800
Disease	Cardiac Hypertrophy	PPARD PRKCA PLD1	2.83e-03	82	101	3	C1383860
Disease	congenital heart disease (is_implicated_in)	MYH7 NOTCH1	3.05e-03	24	101	2	DOID:1682 (is_implicated_in)
Disease	trans fatty acid measurement, trans/trans-18:2 fatty acid measurement	DIPK1A RYR3	3.05e-03	24	101	2	EFO_0006821, EFO_0006826

Protein segments in the cluster

Peptide	Gene	Start	Entry
KIPFIILSEEFIDPK	VANGL1	496	Q8TAA9
SPEEKIFLREFPRLK	APOL6	36	Q9BWW8
IPREPKAGEFDKIIR	GRM4	256	Q14833
DFQKRKLLDPEPSFL	GSDMC	131	Q9BYG8
PTFFERPLVRKAFEK	AKR1B10	81	O60218
RIKVDFVIPKELPFG	CSDE1	286	O75534
FLEPREITLPEAKDK	TENT2	141	Q6PIY7
AIDKRFRVFTKPVDP	ATAD2	1001	Q6PL18
PPFSEKFFLVVIEKD	DMXL2	886	Q8TDJ6
KPLFEFVREALKPVD	ELP6	116	Q0PNE2
APEFPFKTKEIRVEE	CDHR5	121	Q9HBB8
EEEEKRDVFEFPLPK	ANKRD34A	206	Q69YU3
PFFKATPEEKLKLED	G6PD	86	P11413
AQTRPFDLKKDVFVP	MYH7	26	P12883
KILAAPNTFFEPRKE	ANKRD31	186	Q8N7Z5
KEVFRPLKPADLTAL	MAP4K4	731	O95819
FLGRPFPFKDKLVVE	MDN1	2801	Q9NU22
KKFRFEEPVVLPDLD	NOTCH1	1821	P46531
FEVKEIFRKSPFLVP	ENTPD5	146	O75356
LKIPPFEKARSVLEA	NEIL1	186	Q96FI4
DFLKIKIPDRFPERK	KCTD16	401	Q68DU8
LRKPSKEEPLFAARV	ITPR1	2561	Q14643
TPLPRLFLDEVAKKI	HERC2	3891	O95714
PFSKRIKLEKEFDLP	BCL11A	631	Q9H165
PPADAKALEEARKIF	GSTA3	206	Q16772
DFFKVRPDDLKLPTD	NCF1	116	P14598
KLFIFRNPKEPEISL	EVC2	1271	Q86UK5
KAAPLLREIFVDFAP	LRBA	1806	P50851
ALKKVRIFDSPEELP	NUP214	21	P35658
IKIIDFGFARLKPPD	RPS6KA5	561	O75582
PRARKEPKEITFLDA	INF2	621	Q27J81
LDFFKVRPDDLKLPT	NCF1B	116	A6NI72
LDFFKVRPDDLKLPT	NCF1C	91	A8MVU1
REKPLPTFKDLDFLQ	PIPSL	221	A2A3N6
LEKFFETRVAGPPFK	MED14	1281	O60244
PTFKFEDPKFEVIEK	ATP5PF	91	P18859
RAVIEKIPEDDKPSF	DYNC2H1	3981	Q8NCM8
RKKFLEVPRFDKENP	ATM	1771	Q13315
IELFRKLPFSKREVP	HTRA1	186	Q92743
PALDVPRKRDLNFEK	DNAH17	2076	Q9UFH2
LTSALLFFRPEKPKE	EFCAB10	26	A6NFE3
RPRVLTIDPTEFKFK	COPA	586	P53621
VAFIESLKRADKIPP	FANCA	601	O15360
EPIKEFQKEAEKFLP	CEP350	1026	Q5VT06
EERLKVIPKFCFPDS	DENND2C	531	Q68D51
PKVLRIFPDKFVLKE	CEP192	1941	Q8TEP8
LAFIKRTPVIDADKP	DYNC1H1	116	Q14204
FRTIVKPVAKEFDPD	HDAC9	891	Q9UKV0
TELEPRKEIVLFDKP	DIPK1A	126	Q5T7M9
PEYLPEDKVIIFLKD	MIER1	216	Q8N108
KENEAFEFKKPVRPV	CDC25A	141	P30304
RETFLPPLDKTKFLV	MAP1LC3C	46	Q9BXW4
EEKIKEFHPTFDPLI	CFAP221	436	Q4G0U5
PFSKVPEAFLKVERG	RTN4IP1	371	Q8WWV3
PILVEKFPFVRKSER	RRN3	206	Q9NYV6
KVFFGLLKEPEIEVP	TAF5	371	Q15542
AIKRDPNLFPFEKEG	MRPL40	161	Q9NQ50
ELKFPHKEKPDLEFV	SULT1C3	91	Q6IMI6
LRKKVFEKDFGPIDP	QTRT1	301	Q9BXR0
RKPFSDIIEPKFEFA	PPARD	321	Q03181
NPVFREKVTFAKLEP	SYT16	411	Q17RD7
VEKRVLALLDKPPFL	PRKCA	386	P17252
LEFKLVFGEEKEAPP	NFATC4	11	Q14934
LRDFINKPVLAKEDP	PLD1	1016	Q13393
EPIPLTIKAIFERFK	TAF1D	71	Q9H5J8
KEFNERFKEKLPAPI	SLC26A5	276	P58743
RFKEKLPAPIPLEFF	SLC26A5	281	P58743
FPEKFFPKARDLVEK	PDPK1	301	O15530
RPIFVFDGDAPLLKK	ERCC5	71	P28715
VPKLALFAAKDIVPE	SETMAR	241	Q53H47
VKAADEDVFRKPGLP	SETX	1571	Q7Z333
EKPIPLFVEKCVEFI	ARHGAP5	1271	Q13017
IEFPLPDEKTKKRIF	PSMC1	351	P62191
VKFPDLDRNVPRKTF	SLC35D1	96	Q9NTN3
FKRDPEDPSAVALKE	PI4KB	521	Q9UBF8
NRDFSLPVPKFKLDE	SETD1A	71	O15047
AKKDFFRLPDPFAKI	SMURF1	26	Q9HCE7
KRFKFEEPLLQEIPG	STK17A	396	Q9UEE5
PTFFERPLVRKAFEK	AKR1B15	81	C9JRZ8
LVTRPQKPSLEFKEF	ACD	361	Q96AP0
QPPRDLTEAFLAKKE	CYP2D7	266	A0A087X1C5
KKDFFRLPDPFAKVV	SMURF2	26	Q9HAU4
FPREPICPFEEKTKI	ZNF562	11	Q6V9R5
QPFKFTIPESLDRIK	TLE1	16	Q04724
DFEGVPVFIPFQRKK	ZFP41	71	Q8N8Y5
LFPCKDVEKDFPTIL	ZNF549	181	Q6P9A3
VEFAAKPPARKALER	PSPC1	201	Q8WXF1
LRKEGFDPAIVKDPL	SLC27A4	601	Q6P1M0
PRDQEIKFFAKVLLP	RYR3	2851	Q15413
PLASVLRAKPDFKEL	RNH1	161	P13489
PISKKVARDPRFDDL	RRP36	111	Q96EU6
PDFREHIAKIFEKPV	TACC2	1406	O95359
EPKFEKFLDAVDPGR	SPTA1	2316	P02549
RPFPEEVDKIPFVKA	RALGAPB	1026	Q86X10
EPDKRPVFADISKDL	RET	991	P07949
FKEFLEEIIKRVFDP	UBE3B	731	Q7Z3V4
KKAPADFLEKFLPRE	TSSK1B	46	Q9BXA7
PIFFKRKLDPAEPFA	WDR24	376	Q96S15
PKERPRFAELVEKLG	FLT1	1141	P17948
KKTPTDFVERFLPRE	TSSK2	46	Q96PF2
EPFRSKVLKDLPRVE	PC	961	P11498
KRTPPKAFEVEQDFK	WDR64	966	B1ANS9
PDDFKFKNPVLVVVD	VPS13D	721	Q5THJ4
VLKPVFAREKEPFSL	MYOM3	276	Q5VTT5