Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionandrosterone dehydrogenase (B-specific) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.69e-104894GO:0047042
GeneOntologyMolecularFunctionketoreductase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.69e-104894GO:0045703
GeneOntologyMolecularFunctionchlordecone reductase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.69e-104894GO:0047743
GeneOntologyMolecularFunctiontrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.84e-095894GO:0047115
GeneOntologyMolecularFunction15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.84e-095894GO:0047020
GeneOntologyMolecularFunction17-beta-ketosteroid reductase (NADPH) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.84e-095894GO:0072555
GeneOntologyMolecularFunction17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.84e-095894GO:0047006
GeneOntologyMolecularFunctionlithocholic acid binding

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.84e-095894GO:1902121
GeneOntologyMolecularFunctionketosteroid monooxygenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.84e-095894GO:0047086
GeneOntologyMolecularFunctionDelta4-3-oxosteroid 5beta-reductase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.84e-095894GO:0047787
GeneOntologyMolecularFunctiongeranylgeranyl reductase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.49e-096894GO:0045550
GeneOntologyMolecularFunction17-beta-hydroxysteroid dehydrogenase (NADP+) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.28e-087894GO:0072582
GeneOntologyMolecularFunction5alpha-androstane-3beta,17beta-diol dehydrogenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.55e-088894GO:0047024
GeneOntologyMolecularFunctionandrosterone dehydrogenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.55e-088894GO:0047023
GeneOntologyMolecularFunctionenone reductase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.55e-088894GO:0035671
GeneOntologyMolecularFunctionandrostan-3-alpha,17-beta-diol dehydrogenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.57e-089894GO:0047044
GeneOntologyMolecularFunctionNADP+ binding

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.57e-089894GO:0070401
GeneOntologyMolecularFunctiontestosterone 17-beta-dehydrogenase (NADP+) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.59e-0810894GO:0047045
GeneOntologyMolecularFunctionbile acid binding

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.59e-0810894GO:0032052
GeneOntologyMolecularFunctionaldose reductase (NADPH) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.57e-0714894GO:0004032
GeneOntologyMolecularFunctionretinal dehydrogenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.57e-0714894GO:0001758
GeneOntologyMolecularFunctionestradiol 17-beta-dehydrogenase [NAD(P)+] activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.69e-0620894GO:0004303
GeneOntologyMolecularFunctionall-trans-retinol dehydrogenase (NAD+) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.66e-0624894GO:0004745
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors

AOX1 AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.01e-0656895GO:0016903
GeneOntologyMolecularFunctionalcohol dehydrogenase (NAD+) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.11e-0626894GO:0004022
GeneOntologyMolecularFunctionNADPH binding

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.11e-0626894GO:0070402
GeneOntologyMolecularFunctionalcohol dehydrogenase (NADP+) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.98e-0627894GO:0008106
GeneOntologyMolecularFunctionalcohol dehydrogenase [NAD(P)+] activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.25e-0630894GO:0018455
GeneOntologyMolecularFunctionaldo-keto reductase (NADPH) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.21e-0532894GO:0004033
GeneOntologyMolecularFunctionsteroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.37e-0533894GO:0033764
GeneOntologyMolecularFunctiontestosterone dehydrogenase [NAD(P)+] activity

AKR1C3 AKR1C4 AKR1C1

1.38e-0511893GO:0030283
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.54e-0534894GO:0016628
GeneOntologyMolecularFunctionsteroid dehydrogenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.69e-0539894GO:0016229
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.98e-0540894GO:0016709
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.18e-0548894GO:0016620
GeneOntologyMolecularFunctionindanol dehydrogenase activity

AKR1C1 AKR1C2

1.17e-044892GO:0047718
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.49e-0460894GO:0016655
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.69e-0462894GO:0016627
GeneOntologyMolecularFunctionNADP binding

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.69e-0462894GO:0050661
GeneOntologyMolecularFunctionlipoteichoic acid binding

CD6 TLR2

4.07e-047892GO:0070891
GeneOntologyMolecularFunctiontestosterone dehydrogenase (NAD+) activity

AKR1C3 AKR1C4

6.93e-049892GO:0047035
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.62e-0495894GO:0016651
GeneOntologyMolecularFunctionmonocarboxylic acid binding

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.34e-03107894GO:0033293
GeneOntologyMolecularFunctionmonooxygenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.75e-03115894GO:0004497
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

AKR1C3 RIOX1 AKR1C4 AKR1C1 AKR1C2

1.76e-03194895GO:0016705
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.51e-03127894GO:0016616
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH5 DNAH11

2.87e-0318892GO:0008569
GeneOntologyMolecularFunctionsteroid binding

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.97e-03133894GO:0005496
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH-OH group of donors

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.39e-03138894GO:0016614
GeneOntologyMolecularFunctionproteasome binding

SACS ECPAS

3.54e-0320892GO:0070628
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

TRIO PLEKHG4 MCF2L2 PREX2 VAV2

3.75e-03231895GO:0005085
GeneOntologyMolecularFunctionlipid binding

CD6 SVIL TLR2 MTTP AKR1C3 APPL1 AKR1C4 BAIAP3 AKR1C1 AKR1C2 ITPR2

4.40e-039888911GO:0008289
GeneOntologyBiologicalProcessresponse to jasmonic acid

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.95e-104874GO:0009753
GeneOntologyBiologicalProcessprogesterone catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.95e-104874GO:0006709
GeneOntologyBiologicalProcesscellular response to jasmonic acid stimulus

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.95e-104874GO:0071395
GeneOntologyBiologicalProcessC21-steroid hormone catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.95e-104874GO:0008208
GeneOntologyBiologicalProcessfarnesol metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.47e-095874GO:0016487
GeneOntologyBiologicalProcessfarnesol catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.47e-095874GO:0016488
GeneOntologyBiologicalProcessnegative regulation of isoprenoid metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.47e-095874GO:0045827
GeneOntologyBiologicalProcesssesquiterpenoid catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.47e-095874GO:0016107
GeneOntologyBiologicalProcessolefinic compound catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.47e-095874GO:0120256
GeneOntologyBiologicalProcessnegative regulation of retinoic acid biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.47e-095874GO:1900053
GeneOntologyBiologicalProcesssesquiterpenoid metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.40e-096874GO:0006714
GeneOntologyBiologicalProcesspolyprenol catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.40e-096874GO:0016095
GeneOntologyBiologicalProcessresponse to prostaglandin D

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.02e-087874GO:0071798
GeneOntologyBiologicalProcesscellular response to prostaglandin D stimulus

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.02e-087874GO:0071799
GeneOntologyBiologicalProcessregulation of retinoic acid biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.02e-087874GO:1900052
GeneOntologyBiologicalProcessregulation of retinoic acid receptor signaling pathway

AKR1C3 AKR1C4 CNOT1 AKR1C1 AKR1C2

2.29e-0821875GO:0048385
GeneOntologyBiologicalProcessdaunorubicin metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.66e-089874GO:0044597
GeneOntologyBiologicalProcessdoxorubicin metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.08e-0810874GO:0044598
GeneOntologyBiologicalProcessregulation of isoprenoid metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.08e-0810874GO:0019747
GeneOntologyBiologicalProcessnegative regulation of vitamin metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.08e-0810874GO:0046137
GeneOntologyBiologicalProcesspolyketide metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.08e-0810874GO:0030638
GeneOntologyBiologicalProcessaminoglycoside antibiotic metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.08e-0810874GO:0030647
GeneOntologyBiologicalProcessregulation of testosterone biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.53e-0811874GO:2000224
GeneOntologyBiologicalProcessterpenoid catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.53e-0811874GO:0016115
GeneOntologyBiologicalProcessretinoic acid biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.86e-0714874GO:0002138
GeneOntologyBiologicalProcessisoprenoid catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.86e-0714874GO:0008300
GeneOntologyBiologicalProcessditerpenoid biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.89e-0715874GO:0016102
GeneOntologyBiologicalProcesstestosterone biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.17e-0716874GO:0061370
GeneOntologyBiologicalProcessnegative regulation of hormone metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.17e-0716874GO:0032351
GeneOntologyBiologicalProcessretinoic acid receptor signaling pathway

AKR1C3 AKR1C4 CNOT1 AKR1C1 AKR1C2

5.35e-0738875GO:0048384
GeneOntologyBiologicalProcessregulation of vitamin metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.64e-0718874GO:0030656
GeneOntologyBiologicalProcesshormone catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.67e-0621874GO:0042447
GeneOntologyBiologicalProcessterpenoid biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.67e-0621874GO:0016114
GeneOntologyBiologicalProcessretinal metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.67e-0621874GO:0042574
GeneOntologyBiologicalProcessketone catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.67e-0621874GO:0042182
GeneOntologyBiologicalProcessparturition

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.04e-0622874GO:0007567
GeneOntologyBiologicalProcessglycoside metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.04e-0622874GO:0016137
GeneOntologyBiologicalProcessprogesterone metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.04e-0622874GO:0042448
GeneOntologyBiologicalProcesstertiary alcohol metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.04e-0622874GO:1902644
GeneOntologyBiologicalProcesscellular response to prostaglandin stimulus

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.46e-0623874GO:0071379
GeneOntologyBiologicalProcessprimary alcohol catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.46e-0623874GO:0034310
GeneOntologyBiologicalProcessregulation of ketone biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.11e-0626874GO:0010566
GeneOntologyBiologicalProcesspositive regulation of epithelial cell apoptotic process

MTOR AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.41e-0660875GO:1904037
GeneOntologyBiologicalProcessnegative regulation of mRNA splicing, via spliceosome

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.60e-0628874GO:0048025
GeneOntologyBiologicalProcesspolyprenol metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.47e-0629874GO:0016093
GeneOntologyBiologicalProcessnegative regulation of mRNA processing

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.47e-0629874GO:0050686
GeneOntologyBiologicalProcesssecondary metabolic process

AKR1C3 APPL1 AKR1C4 AKR1C1 AKR1C2

9.34e-0667875GO:0019748
GeneOntologyBiologicalProcesspositive regulation of endothelial cell apoptotic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.70e-0632874GO:2000353
GeneOntologyBiologicalProcessresponse to fatty acid

TLR2 AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.08e-0569875GO:0070542
GeneOntologyBiologicalProcessnegative regulation of RNA splicing

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.10e-0533874GO:0033119
GeneOntologyBiologicalProcesssteroid catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.24e-0534874GO:0006706
GeneOntologyBiologicalProcessolefinic compound biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.40e-0535874GO:0120255
GeneOntologyBiologicalProcessresponse to prostaglandin

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.57e-0536874GO:0034694
GeneOntologyBiologicalProcessisoprenoid biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.57e-0536874GO:0008299
GeneOntologyBiologicalProcessretinoic acid metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.40e-0540874GO:0042573
GeneOntologyBiologicalProcesscellular response to fatty acid

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.92e-0542874GO:0071398
GeneOntologyBiologicalProcesscellular response to calcium ion

AKR1C3 AKR1C4 ADGRV1 AKR1C1 AKR1C2

3.54e-0588875GO:0071277
GeneOntologyBiologicalProcesspositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

MTOR AKR1C3 AKR1C4 AKR1C1 AKR1C2 MUSK VAV2

3.71e-05217877GO:0051897
GeneOntologyBiologicalProcessC21-steroid hormone metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.86e-0545874GO:0008207
GeneOntologyBiologicalProcessprotein localization to kinetochore

KNTC1 CDK1 ZW10

3.90e-0516873GO:0034501
GeneOntologyBiologicalProcessprotein localization to condensed chromosome

KNTC1 CDK1 ZW10

3.90e-0516873GO:1903083
GeneOntologyBiologicalProcessalcohol catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.59e-0547874GO:0046164
GeneOntologyBiologicalProcessresponse to calcium ion

MTTP AKR1C3 AKR1C4 ADGRV1 AKR1C1 AKR1C2

6.17e-05161876GO:0051592
GeneOntologyBiologicalProcessprostaglandin metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.17e-0556874GO:0006693
GeneOntologyBiologicalProcessprostanoid metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.83e-0557874GO:0006692
GeneOntologyBiologicalProcessketone biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.83e-0557874GO:0042181
GeneOntologyBiologicalProcessregulation of hormone metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.05e-0458874GO:0032350
GeneOntologyBiologicalProcessnegative regulation of mRNA metabolic process

MTOR AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.27e-04115875GO:1903312
GeneOntologyBiologicalProcessregulation of attachment of spindle microtubules to kinetochore

KNTC1 CDK1 ZW10

1.38e-0424873GO:0051988
GeneOntologyBiologicalProcesssperm motility

ENO4 INPP5B PDILT CFAP61 DNAH5 DNAH11

1.67e-04193876GO:0097722
GeneOntologyBiologicalProcessphosphatidylinositol 3-kinase/protein kinase B signal transduction

MTOR AKR1C3 AKR1C4 AKR1C1 AKR1C2 MUSK PREX2 VAV2

2.10e-04382878GO:0043491
GeneOntologyBiologicalProcesscellular response to alcohol

AKR1C3 AKR1C4 AKR1C1 AKR1C2 ITPR2

2.25e-04130875GO:0097306
GeneOntologyBiologicalProcessorganic hydroxy compound catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.57e-0473874GO:1901616
GeneOntologyBiologicalProcessregulation of endothelial cell apoptotic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.71e-0474874GO:2000351
GeneOntologyBiologicalProcessxenobiotic metabolic process

AOX1 AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.28e-04141875GO:0006805
GeneOntologyBiologicalProcessicosanoid metabolic process

TLR2 AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.38e-04142875GO:0006690
GeneOntologyBiologicalProcessendothelial cell apoptotic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.49e-0479874GO:0072577
GeneOntologyBiologicalProcesscellular response to xenobiotic stimulus

AOX1 AKR1C3 AKR1C4 AKR1C1 AKR1C2 VAV2

3.55e-04222876GO:0071466
GeneOntologyBiologicalProcesscellular response to corticosteroid stimulus

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.84e-0481874GO:0071384
GeneOntologyBiologicalProcessregulation of epithelial cell apoptotic process

MTOR AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.62e-04152875GO:1904035
GeneOntologyBiologicalProcessregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

MTOR AKR1C3 AKR1C4 AKR1C1 AKR1C2 MUSK VAV2

5.29e-04334877GO:0051896
GeneOntologyBiologicalProcesspositive regulation of reactive oxygen species metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.49e-0489874GO:2000379
GeneOntologyBiologicalProcessretinoid metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.49e-0489874GO:0001523
GeneOntologyBiologicalProcesshormone-mediated signaling pathway

AKR1C3 APPL1 AKR1C4 CNOT1 AKR1C1 AKR1C2

5.85e-04244876GO:0009755
GeneOntologyBiologicalProcessnegative regulation of lipid biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.97e-0491874GO:0051055
GeneOntologyBiologicalProcessditerpenoid metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.74e-0494874GO:0016101
GeneOntologyBiologicalProcessaldehyde metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.02e-0495874GO:0006081
GeneOntologyBiologicalProcessglycosyl compound metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.30e-0496874GO:1901657
GeneOntologyBiologicalProcessprotein localization to chromosome, centromeric region

KNTC1 CDK1 ZW10

7.39e-0442873GO:0071459
GeneOntologyBiologicalProcesscilium movement

ENO4 INPP5B CFAP61 DNAH5 AK7 DNAH11

8.31e-04261876GO:0003341
GeneOntologyBiologicalProcessresponse to estrogen

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.50e-04103874GO:0043627
GeneOntologyBiologicalProcessterpenoid metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.02e-03105874GO:0006721
GeneOntologyBiologicalProcessprimary alcohol metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.06e-03106874GO:0034308
GeneOntologyBiologicalProcessregulation of steroid biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.06e-03106874GO:0050810
GeneOntologyBiologicalProcessflagellated sperm motility

ENO4 INPP5B CFAP61 DNAH5 DNAH11

1.15e-03186875GO:0030317
GeneOntologyBiologicalProcesslipid catabolic process

MTOR LIPH AKR1C3 AKR1C4 AKR1C1 AKR1C2 ABHD16A

1.16e-03382877GO:0016042
GeneOntologyBiologicalProcessregulation of ketone metabolic process

MTOR AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.23e-03189875GO:0010565
GeneOntologyBiologicalProcessheart development

AP1B1 AP2B1 DSP MTOR SYNE1 PDS5A PRKDC CDK1 DNAH5 DNAH11

1.31e-037578710GO:0007507
GeneOntologyBiologicalProcessepithelial cell apoptotic process

MTOR AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.32e-03192875GO:1904019
GeneOntologyBiologicalProcessnuclear receptor-mediated signaling pathway

AKR1C3 AKR1C4 CNOT1 AKR1C1 AKR1C2

1.65e-03202875GO:0141193
GeneOntologyCellularComponentRZZ complex

KNTC1 ZW10

5.48e-053902GO:1990423
GeneOntologyCellularComponent9+0 motile cilium

DNAH5 DNAH11

2.72e-046902GO:0097728
MousePhenoparturition failure

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.12e-0710694MP:0012010
MousePhenohypermyelination

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.75e-0711694MP:0010050
MousePhenoincreased oligodendrocyte number

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.76e-0713694MP:0010160
MousePhenoincreased circulating progesterone level

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.12e-0715694MP:0005186
MousePhenolong stride length

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.12e-0715694MP:0010540
MousePhenolong gestation period

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.12e-0715694MP:0002293
MousePhenoabnormal gestational length

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.58e-0618694MP:0002292
MousePhenodysmyelination

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.48e-0620694MP:0013438
MousePhenoabnormal respiratory system physiology

ILF3 TMTC3 AP1B1 KCNJ3 TLR2 AKR1C3 PDS5A AKR1C4 PRKDC DNAH5 AKR1C1 AKR1C2 AK7 MUSK DNAH11 HELLS

5.52e-068976916MP:0002133
MousePhenodecreased oligodendrocyte number

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.36e-0625694MP:0009808
MousePhenoabnormal respiratory motile cilium physiology

AP1B1 DNAH5 AK7 DNAH11

1.18e-0529694MP:0011055
MousePhenoprolonged diestrus

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.35e-0530694MP:0009011
MousePhenoabnormal parturition

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.00e-0533694MP:0002907
MousePhenobiventricular, ambiguous atrioventricular connection

DNAH5 DNAH11

2.40e-052692MP:0011511
MousePhenoabnormal diestrus

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.54e-0535694MP:0009010
MousePhenoenhanced coordination

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.54e-0538694MP:0003858
MousePhenoprolonged estrous cycle

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.92e-0539694MP:0009006
MousePhenoabnormal stride length

AKR1C3 AKR1C4 AKR1C1 AKR1C2 PREX2

5.14e-0582695MP:0012690
MousePhenoabnormal anxiety-related response

NDST3 DCDC2 KCNJ3 MC2R SPPL3 AKR1C3 AKR1C4 TMEM35A ECPAS BAIAP3 AKR1C1 AKR1C2 BTBD3

5.69e-057406913MP:0001362
MousePhenobiventricular, discordant atrioventricular connection

DNAH5 DNAH11

7.18e-053692MP:0011510
MousePhenoimmotile respiratory cilia

AP1B1 DNAH5 DNAH11

7.45e-0517693MP:0011649
MousePhenodecreased vocalization

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.59e-0546694MP:0020351
MousePhenorespiratory system inflammation

AKR1C3 AKR1C4 PRKDC DNAH5 AKR1C1 AKR1C2 AK7

1.02e-04220697MP:0002405
MousePhenoabnormal circulating progesterone level

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.05e-0450694MP:0005184
MousePhenoabnormal motile cilium physiology

AP1B1 DNAH5 AK7 DNAH11

1.14e-0451694MP:0013209
MousePhenoabnormal respiratory epithelium physiology

AP1B1 DNAH5 AK7 DNAH11

1.14e-0451694MP:0014200
MousePhenoabnormal oligodendrocyte morphology

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.14e-0451694MP:0000953
MousePhenoabnormal cilium physiology

AP1B1 DNAH5 AK7 DNAH11

1.33e-0453694MP:0013208
MousePhenoincreased stereotypic behavior

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.33e-0453694MP:0001409
MousePhenoabnormal progesterone level

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.43e-0454694MP:0011384
MousePhenositus inversus totalis

AP1B1 DNAH5 DNAH11

1.90e-0423693MP:0011252
MousePhenoheart left ventricle hypertrophy

AP2B1 DNAH5 VAV2 DNAH11

2.93e-0465694MP:0002625
MousePhenoleft pulmonary isomerism

AP1B1 DNAH5 DNAH11

4.69e-0431693MP:0003178
MousePhenoabnormal fear/anxiety-related behavior

NDST3 DCDC2 KCNJ3 MC2R SPPL3 AKR1C3 AKR1C4 TMEM35A ECPAS BAIAP3 AKR1C1 AKR1C2 BTBD3

4.86e-049196913MP:0002065
MousePhenosuperior-inferior ventricles

DNAH5 DNAH11

4.96e-047692MP:0011254
MousePhenositus inversus with levocardia

DNAH5 DNAH11

4.96e-047692MP:0011253
MousePhenoincreased circulating hormone level

SLC16A2 TLR2 MC2R AKR1C3 APPL1 AKR1C4 TMEM35A AKR1C1 AKR1C2 VAV2

5.09e-045786910MP:0014456
MousePhenoleft-sided isomerism

AP1B1 DNAH5 DNAH11

6.17e-0434693MP:0000542
MousePhenoleft atrial isomerism

DNAH5 DNAH11

6.60e-048692MP:0008461
MousePhenodecreased circulating LDL cholesterol level

SLC16A2 MTOR MTTP HELLS

7.79e-0484694MP:0000183
MousePhenoatrioventricular septal defect

AP2B1 PDS5A DNAH5 DNAH11

7.79e-0484694MP:0010412
MousePhenoabdominal situs inversus

DNAH5 DNAH11

8.45e-049692MP:0011249
MousePhenodecreased B cell proliferation

CD6 MTOR PRKDC VAV2

8.51e-0486694MP:0005093
MousePhenoabnormal atrioventricular septum morphology

AP2B1 PDS5A DNAH5 DNAH11

8.89e-0487694MP:0010592
MousePhenooxidative stress

ABCB10 AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.14e-04152695MP:0003674
MousePhenoabnormal gait

SACS AKR1C3 AKR1C4 DNAH5 AKR1C1 AKR1C2 MUSK PREX2 HELLS

9.89e-04520699MP:0001406
MousePhenoincreased hormone level

SLC16A2 TLR2 MC2R AKR1C3 APPL1 AKR1C4 TMEM35A AKR1C1 AKR1C2 VAV2

1.13e-036416910MP:0014454
MousePhenoheart right ventricle hypertrophy

AP2B1 DNAH5 DNAH11

1.15e-0342693MP:0000276
MousePhenoabnormal circulating LDL cholesterol level

SLC16A2 MTOR TLR2 MTTP HELLS

1.25e-03163695MP:0000181
DomainALDOKETO_REDUCTASE_1

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.03e-0810874PS00798
DomainAldo/ket_reductase_CS

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.03e-0810874IPR018170
DomainAldo/keto_reductase

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.03e-0810874IPR020471
DomainALDOKETO_REDUCTASE_2

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.03e-0810874PS00062
DomainALDOKETO_REDUCTASE_3

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.03e-0810874PS00063
DomainARM-type_fold

ELMO3 AP1B1 AP2B1 MTOR CIP2A PDS5A PRKDC API5 ECPAS ITPR2 XPO7

4.90e-073398711IPR016024
DomainARM-like

ELMO3 AP1B1 AP2B1 MTOR CIP2A PDS5A PRKDC API5 ECPAS XPO7

5.07e-072708710IPR011989
Domain-

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.66e-07168743.20.20.100
DomainNADP_OxRdtase_dom

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.98e-0717874IPR023210
DomainAldo_ket_red

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.98e-0717874PF00248
DomainAldo/ket_red/Kv-b

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.98e-0717874IPR001395
Domain-

AP1B1 AP2B1 MTOR CIP2A PDS5A PRKDC API5 ECPAS

9.16e-062228781.25.10.10
DomainDH_1

TRIO PLEKHG4 MCF2L2 PREX2 VAV2

1.11e-0563875PS00741
DomainSpectrin/alpha-actinin

TRIO DSP SYNE1 MCF2L2

1.43e-0532874IPR018159
DomainSPEC

TRIO DSP SYNE1 MCF2L2

1.43e-0532874SM00150
DomainRhoGEF

TRIO PLEKHG4 MCF2L2 PREX2 VAV2

1.62e-0568875SM00325
DomainRhoGEF

TRIO PLEKHG4 MCF2L2 PREX2 VAV2

1.86e-0570875PF00621
DomainDH_2

TRIO PLEKHG4 MCF2L2 PREX2 VAV2

1.86e-0570875PS50010
DomainDH-domain

TRIO PLEKHG4 MCF2L2 PREX2 VAV2

2.00e-0571875IPR000219
Domain-

TRIO PLEKHG4 MCF2L2 PREX2 VAV2

2.00e-05718751.20.900.10
Domain-

AP1B1 AP2B1

2.14e-0528722.60.40.1150
DomainClathrin_b-adaptin_app_Ig-like

AP1B1 AP2B1

2.14e-052872IPR013037
DomainGDS_CDC24_CS

TRIO PLEKHG4 PREX2 VAV2

3.19e-0539874IPR001331
DomainAP_complex_bsu_1_2_4

AP1B1 AP2B1

6.42e-053872IPR016342
DomainB2-adapt-app_C

AP1B1 AP2B1

6.42e-053872PF09066
DomainB-adaptin_app_sub_C

AP1B1 AP2B1

1.28e-044872IPR015151
DomainB2-adapt-app_C

AP1B1 AP2B1

1.28e-044872SM01020
DomainAP_beta

AP1B1 AP2B1

2.13e-045872IPR026739
DomainFATC

MTOR PRKDC

2.13e-045872PF02260
DomainCRAL-TRIO_dom

TRIO PLEKHG4 MCF2L2

2.94e-0428873IPR001251
DomainPH

ELMO3 TRIO PLEKHG4 MCF2L2 APPL1 PREX2 VAV2

3.18e-04278877SM00233
DomainFAT

MTOR PRKDC

3.18e-046872PS51189
DomainFATC

MTOR PRKDC

3.18e-046872PS51190
DomainFAT

MTOR PRKDC

3.18e-046872PF02259
DomainPIK-rel_kinase_FAT

MTOR PRKDC

3.18e-046872IPR003151
DomainFATC_dom

MTOR PRKDC

3.18e-046872IPR003152
DomainPIK_FAT

MTOR PRKDC

3.18e-046872IPR014009
DomainBeta2_adaptin/TBP_C_dom

AP1B1 AP2B1

3.18e-046872IPR012295
DomainFATC

MTOR PRKDC

3.18e-046872SM01343
Domain-

AP1B1 AP2B1

3.18e-0468723.30.310.10
DomainHEAT_REPEAT

MTOR PDS5A PRKDC ECPAS

3.19e-0470874PS50077
DomainPH_DOMAIN

ELMO3 TRIO PLEKHG4 MCF2L2 APPL1 PREX2 VAV2

3.25e-04279877PS50003
DomainSpectrin_repeat

TRIO DSP SYNE1

3.27e-0429873IPR002017
DomainPH_domain

ELMO3 TRIO PLEKHG4 MCF2L2 APPL1 PREX2 VAV2

3.32e-04280877IPR001849
DomainCoatomer/calthrin_app_sub_C

AP1B1 AP2B1

5.90e-048872IPR009028
DomainDHC_N1

DNAH5 DNAH11

5.90e-048872PF08385
DomainDynein_heavy_dom-1

DNAH5 DNAH11

5.90e-048872IPR013594
DomainClathrin_a/b/g-adaptin_app_Ig

AP1B1 AP2B1

7.56e-049872IPR008152
DomainAlpha_adaptinC2

AP1B1 AP2B1

7.56e-049872PF02883
DomainAlpha_adaptinC2

AP1B1 AP2B1

7.56e-049872SM00809
DomainCoatomer/clathrin_app_Ig-like

AP1B1 AP2B1

1.37e-0312872IPR013041
DomainDynein_heavy_chain_D4_dom

DNAH5 DNAH11

1.88e-0314872IPR024317
DomainDynein_HC_stalk

DNAH5 DNAH11

1.88e-0314872IPR024743
DomainDynein_heavy_dom-2

DNAH5 DNAH11

1.88e-0314872IPR013602
DomainDHC_N2

DNAH5 DNAH11

1.88e-0314872PF08393
DomainMT

DNAH5 DNAH11

1.88e-0314872PF12777
DomainAAA_8

DNAH5 DNAH11

1.88e-0314872PF12780
DomainATPase_dyneun-rel_AAA

DNAH5 DNAH11

1.88e-0314872IPR011704
DomainAAA_5

DNAH5 DNAH11

1.88e-0314872PF07728
DomainDHC_fam

DNAH5 DNAH11

2.17e-0315872IPR026983
DomainClathrin/coatomer_adapt-like_N

AP1B1 AP2B1

2.17e-0315872IPR002553
DomainAdaptin_N

AP1B1 AP2B1

2.17e-0315872PF01602
DomainDynein_heavy_dom

DNAH5 DNAH11

2.17e-0315872IPR004273
DomainDynein_heavy

DNAH5 DNAH11

2.17e-0315872PF03028
DomainPI3/4_kinase_CS

MTOR PRKDC

2.17e-0315872IPR018936
Domain-

ELMO3 TRIO PLEKHG4 MCF2L2 APPL1 PREX2 VAV2

2.32e-033918772.30.29.30
Domain-

MTOR PRKDC

2.47e-03168721.10.1070.11
DomainPI3Kc

MTOR PRKDC

2.47e-0316872SM00146
DomainHEAT

MTOR PRKDC ECPAS

2.50e-0358873IPR000357
DomainPI3/4_kinase_cat_dom

MTOR PRKDC

3.13e-0318872IPR000403
DomainPI3_PI4_kinase

MTOR PRKDC

3.13e-0318872PF00454
DomainPI3_4_KINASE_3

MTOR PRKDC

3.13e-0318872PS50290
DomainPI3_4_KINASE_1

MTOR PRKDC

3.13e-0318872PS00915
DomainPI3_4_KINASE_2

MTOR PRKDC

3.13e-0318872PS00916
DomainPH_dom-like

ELMO3 TRIO PLEKHG4 MCF2L2 APPL1 PREX2 VAV2

3.73e-03426877IPR011993
DomainSRCR

CD6 TMPRSS3

4.25e-0321872PF00530
DomainPH

TRIO PLEKHG4 APPL1 PREX2 VAV2

4.34e-03229875PF00169
PathwayWP_BENZOAPYRENE_METABOLISM

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.18e-089734M39344
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_KEAP1_NRF2_SIGNALIG_PATHWAY

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.18e-089734M47817
PathwayKEGG_MEDICUS_ENV_FACTOR_BENZO_A_PYRENRE_TO_CYP_MEDIATED_METABOLISM

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.12e-0711734M47812
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.57e-0713734M17842
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.57e-0713734MM14747
PathwayWP_GLUCOCORTICOID_BIOSYNTHESIS

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.37e-0714734M46449
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.37e-0714734M27074
PathwayWP_MINERALOCORTICOID_BIOSYNTHESIS

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.37e-0714734M46453
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.37e-0714734MM14748
PathwayREACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.65e-0715734MM14870
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.44e-0623734M1926
PathwayREACTOME_PREDNISONE_ADME

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.44e-0623734MM16639
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.44e-0623734MM14741
PathwayREACTOME_RA_BIOSYNTHESIS_PATHWAY

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.23e-0528734MM15188
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.42e-0533734M5967
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.42e-0533734MM14737
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.68e-0544734M499
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.40e-0545734MM15344
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.40e-0545734MM14751
PathwayREACTOME_SIGNALING_BY_RETINOIC_ACID

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.18e-0449734MM15186
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

LCP2 VAV2 ITPR2

1.22e-0419733M47733
PathwayKEGG_STEROID_HORMONE_BIOSYNTHESIS

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.85e-0455734M14933
PathwayKEGG_MEDICUS_PATHOGEN_YERSINIA_YOPH_TO_TCR_NFAT_SIGNALING_PATHWAY

LCP2 VAV2

2.62e-045732M48994
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.76e-0461734MM14861
PathwayREACTOME_DRUG_ADME

AKR1C3 AKR1C4 AKR1C1 AKR1C2 VAV2

3.74e-04119735MM15692
PathwayKEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.69e-0470734M16794
PathwayPID_RAC1_REG_PATHWAY

TRIO PREX2 VAV2

9.87e-0438733M241
Pubmed

Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490410500239
Pubmed

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490419487289
Pubmed

Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490414967952
Pubmed

Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490410393440
Pubmed

Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490415193432
Pubmed

Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490431479646
Pubmed

Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490416191478
Pubmed

Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490415577209
Pubmed

Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490410702227
Pubmed

Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490417034817
Pubmed

RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490429764944
Pubmed

Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490417888864
Pubmed

Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490417442338
Pubmed

Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490428329705
Pubmed

Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490419237748
Pubmed

Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490428259989
Pubmed

Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490416511129
Pubmed

Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-1149047789999
Pubmed

Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490420124700
Pubmed

Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490416508162
Pubmed

Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490415222881
Pubmed

Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490417629694
Pubmed

Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490410526179
Pubmed

Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490416018803
Pubmed

Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490417272929
Pubmed

Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490418667791
Pubmed

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490421521174
Pubmed

Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-1149048274401
Pubmed

Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490410803568
Pubmed

AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-11490434590152
Pubmed

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.09e-10590421851338
Pubmed

Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.09e-10590416984997
Pubmed

Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.09e-1059047737980
Pubmed

Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.09e-10590417872381
Pubmed

Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.09e-10590417064890
Pubmed

Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.09e-10590410672042
Pubmed

Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F2α (PGF2α) levels.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.09e-10590438788959
Pubmed

Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.09e-10590418003893
Pubmed

Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.26e-10690419273550
Pubmed

Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.26e-10690415471942
Pubmed

MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.26e-10690426748576
Pubmed

The Gαq/11-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.26e-10690429107092
Pubmed

Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.26e-10690415860270
Pubmed

Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.26e-10690417122075
Pubmed

Decidual prolactin silences the expression of genes detrimental to pregnancy.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.26e-10690417255200
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

ILF3 AP1B1 AP2B1 MTOR CIP2A PDS5A APPL1 PRKDC CDK1 API5 ZW10 ECPAS CNOT1 HELLS

1.07e-09638901433239621
Pubmed

MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.46e-09790422529366
Pubmed

A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: Phenotype and impact on adrenocortical function.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.46e-09790433127481
Pubmed

A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.46e-09790412562828
Pubmed

The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.46e-09790426160177
Pubmed

Aldo-ketoreductase 1c19 ablation does not affect insulin secretion in murine islets.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.46e-09790434843575
Pubmed

17Beta-HSD type 5 expression and the emergence of differentiated epithelial Type II cells in fetal lung: a novel role for androgen during the surge of surfactant.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.46e-09790416337335
Pubmed

Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.91e-09890433584538
Pubmed

Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.91e-0989049224647
Pubmed

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.91e-09890420837989
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

KNTC1 TMTC3 TRIO DSP MTOR MTTP PRKDC ECPAS CNOT1

2.96e-0920290933005030
Pubmed

Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.23e-09990433348080
Pubmed

Lack of placental neurosteroid alters cortical development and female somatosensory function.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.70e-091090436313771
Pubmed

MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation.

MC2R AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.72e-092890529879378
Pubmed

Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.

AKR1C3 AKR1C1 AKR1C2

1.68e-08390319320734
Pubmed

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.

AKR1C3 AKR1C1 AKR1C2

1.68e-08390331780644
Pubmed

Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.

AKR1C3 AKR1C1 AKR1C2

1.68e-08390313678667
Pubmed

Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.

AKR1C3 AKR1C4 AKR1C1

1.68e-0839037626489
Pubmed

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.

AKR1C3 AKR1C1 AKR1C2

1.68e-08390321232532
Pubmed

A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-β1.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.04e-081290425774556
Pubmed

Endogenous biotin as a marker of adrenocortical cells with steroidogenic potential.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.04e-081290421256921
Pubmed

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.04e-081290428893949
Pubmed

The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.94e-081390411682476
Pubmed

A link between lung androgen metabolism and the emergence of mature epithelial type II cells.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.94e-081390415117747
Pubmed

Ontogeny of adrenal-like glucocorticoid synthesis pathway and of 20α-hydroxysteroid dehydrogenase in the mouse lung.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.94e-081390424580729
Pubmed

Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.94e-081390417062636
Pubmed

Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.11e-081490419955443
Pubmed

Placental endocrine function shapes cerebellar development and social behavior.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.11e-081490434400844
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

MED15 ILF3 AKR1C3 CPSF1 FARSB PDS5A PRKDC CDK1 API5 ECPAS AKR1C1 AKR1C2 PHC2 HELLS XPO7

5.03e-081014901532416067
Pubmed

Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal Cortex Development and Alters Adrenocortical Cell Fate.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.72e-081790432243503
Pubmed

Functional dynamics of H3K9 methylation during meiotic prophase progression.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.58e-071990417599069
Pubmed

Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.

AKR1C3 AKR1C1 AKR1C2

1.67e-07590315212687
Pubmed

WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.97e-072090424135228
Pubmed

A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.97e-072090423636947
Pubmed

Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.58e-072390423685333
Pubmed

Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.09e-072590426098214
Pubmed

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.

AP2B1 MTOR CIP2A PRKDC CDK1 ZW10 XPO7

5.15e-0718390723956138
Pubmed

Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk.

AKR1C3 AKR1C1 AKR1C2

5.82e-07790319846565
Pubmed

Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.00e-072690423892084
Pubmed

Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.03e-072790417077188
Pubmed

Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.03e-072790423471215
Pubmed

Identification of differentially expressed genes in mouse spermatogenesis.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.03e-072790414581517
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

KNTC1 ILF3 TRIO DSP MTOR SYNE1 CPSF1 FARSB PDS5A PRKDC CDK1 API5 ECPAS DNAH5 CNOT1 HELLS

7.12e-071425901630948266
Pubmed

A protein interaction landscape of breast cancer.

ILF3 AP2B1 TRIO CIP2A SVIL FARSB PDS5A RIOX1 CDK1 ECPAS XPO7

7.66e-07634901134591612
Pubmed

The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.19e-072890429212953
Pubmed

Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.19e-072890421820362
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

MED15 KNTC1 ILF3 AP1B1 AP2B1 FARSB C15orf39 PDS5A PRKDC CDK1 ZW10 ECPAS CNOT1 HELLS

9.20e-071103901434189442
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

TMTC3 DSP MTOR CIP2A PDS5A PRKDC CDK1 ZW10 ECPAS CNOT1 XPO7

1.08e-06657901136180527
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

ILF3 AP1B1 AP2B1 DSP SYNE1 AKR1C3 PRKDC ECPAS CNOT1 AKR1C1 AKR1C2 VAV2

1.17e-06807901230575818
Pubmed

Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.43e-063290434288113
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

ILF3 AP1B1 AP2B1 DSP CIP2A SVIL FARSB PDS5A PRKDC CDK1 API5 ZW10 ECPAS CNOT1

1.49e-061149901435446349
Pubmed

Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.

UBE2G2 AP1B1 AP2B1 PDS5A ECPAS VAV2 HELLS XPO7

2.03e-0632390824797263
Pubmed

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

AKR1C3 FARSB AKR1C4 AKR1C1 AKR1C2 PREX2 HELLS

2.11e-0622690737839992
Pubmed

An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.59e-063790421362171
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

TRIO PLEKHG4 INPP5B SYDE2 MCF2L2 CPSF1 PDS5A APPL1 API5 ECPAS PREX2 VAV2

4.32e-06916901232203420
InteractionC3orf18 interactions

KNTC1 SACS MTOR CIP2A PDS5A PRKDC ZW10 ECPAS XPO7

2.24e-09115909int:C3orf18
InteractionSCN2B interactions

KNTC1 MTOR CIP2A SPPL3 PDS5A ZW10 CNOT1 XPO7

1.02e-0895908int:SCN2B
InteractionFPR1 interactions

KNTC1 PLEKHG4 MTOR CIP2A PDS5A PRKDC ZW10 ECPAS XPO7

1.95e-08147909int:FPR1
InteractionAKR1C4 interactions

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.57e-088904int:AKR1C4
InteractionGPR17 interactions

KNTC1 SACS MTOR CIP2A SPPL3 PDS5A PRKDC ZW10 ECPAS ITPR2 XPO7

5.37e-082839011int:GPR17
InteractionFAM234A interactions

KNTC1 SLC16A2 MTOR CIP2A PDS5A PRKDC ZW10 XPO7

9.42e-08126908int:FAM234A
InteractionCHRM4 interactions

KNTC1 CIP2A SPPL3 PRKDC ZW10 ECPAS XPO7

2.09e-0794907int:CHRM4
InteractionEED interactions

KNTC1 NPRL2 ILF3 CD6 AP2B1 TRIO DSP CIP2A SVIL MTTP CPSF1 FARSB PDS5A RIOX1 PRKDC CDK1 API5 ZW10 CNOT1 PHC2 HELLS XPO7

2.65e-0714459022int:EED
InteractionLRRC31 interactions

KNTC1 TMTC3 TRIO DSP MTOR MTTP PRKDC ECPAS CNOT1

3.39e-07205909int:LRRC31
InteractionCYB5B interactions

KNTC1 SLC16A2 MTOR CIP2A PDS5A TMEM35A ZW10 ECPAS HELLS XPO7

5.77e-072859010int:CYB5B
InteractionMTTP interactions

SPPL3 MTTP PRKDC ADGRV1

1.37e-0619904int:MTTP
InteractionCD80 interactions

KNTC1 MTOR PDS5A PRKDC ZW10 XPO7

1.43e-0679906int:CD80
InteractionAKR1C1 interactions

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.71e-0620904int:AKR1C1
InteractionOPALIN interactions

KNTC1 COX16 MTOR CIP2A PDS5A PRKDC ECPAS XPO7

4.38e-06209908int:OPALIN
InteractionGPR182 interactions

KNTC1 PLEKHG4 MTOR CIP2A SPPL3 PDS5A PRKDC ZW10 ECPAS HELLS XPO7

5.76e-064559011int:GPR182
InteractionP2RY10 interactions

PLEKHG4 CIP2A SPPL3 PRKDC ZW10 ECPAS

7.99e-06106906int:P2RY10
InteractionGYPA interactions

KNTC1 MTOR CIP2A PDS5A ECPAS HELLS XPO7

1.30e-05174907int:GYPA
InteractionAKR1C3 interactions

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.19e-0537904int:AKR1C3
InteractionEDNRB interactions

KNTC1 CIP2A ECPAS XPO7

2.71e-0539904int:EDNRB
InteractionNPTN interactions

KNTC1 PLEKHG4 MTOR CIP2A PDS5A ZW10 ECPAS XPO7

3.46e-05278908int:NPTN
InteractionSGO1 interactions

CIP2A SPPL3 PDS5A PRKDC CDK1 ZW10

3.59e-05138906int:SGO1
InteractionSTIP1 interactions

NPRL2 ILF3 AP1B1 AP2B1 MTOR CIP2A PDS5A APPL1 PRKDC CDK1 API5 ZW10 ECPAS CNOT1 HELLS

3.65e-0510069015int:STIP1
InteractionHCST interactions

MTOR CIP2A PDS5A ZW10 ECPAS HELLS XPO7

3.72e-05205907int:HCST
InteractionRP2 interactions

KNTC1 MTOR PDS5A ECPAS XPO7

6.70e-0595905int:RP2
InteractionPIP5K1C interactions

AP1B1 AP2B1 SPPL3 CDK1

7.32e-0550904int:PIP5K1C
InteractionFLT3 interactions

KNTC1 PDS5A PRKDC CDK1 TMEM225B ECPAS PHC2 HELLS

8.88e-05318908int:FLT3
InteractionCMKLR1 interactions

MTOR PDS5A ZW10 ECPAS HELLS

8.97e-05101905int:CMKLR1
InteractionEFNA4 interactions

KNTC1 DSP CIP2A PDS5A PRKDC ZW10 XPO7

9.79e-05239907int:EFNA4
InteractionAKR1C2 interactions

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.07e-0455904int:AKR1C2
InteractionSIGLECL1 interactions

KNTC1 AP1B1 CIP2A PDS5A ZW10

1.52e-04113905int:SIGLECL1
InteractionNPY2R interactions

MTOR CIP2A PRKDC ECPAS

2.17e-0466904int:NPY2R
InteractionEFNA5 interactions

SLC16A2 MTOR CIP2A ZW10

2.43e-0468904int:EFNA5
InteractionCTDSPL2 interactions

MED15 ILF3 DSP CDK1

2.72e-0470904int:CTDSPL2
InteractionCOMTD1 interactions

KNTC1 MTOR CIP2A PDS5A ZW10 XPO7

2.76e-04200906int:COMTD1
Cytoband10p15-p14

AKR1C3 AKR1C1 AKR1C2

1.45e-07690310p15-p14
CytobandEnsembl 112 genes in cytogenetic band chr10p15

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.10e-0590904chr10p15
GeneFamilyAldo-keto reductases

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.66e-0715624399
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

TRIO PLEKHG4 MCF2L2 PREX2 VAV2

3.06e-0666625722
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

SYDE2 BAIAP3 CCDC33

2.53e-0436623823
GeneFamilyDyneins, axonemal

DNAH5 DNAH11

1.52e-0317622536
CoexpressionIRITANI_MAD1_TARGETS_UP

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.99e-0717904MM826
CoexpressionVARELA_ZMPSTE24_TARGETS_DN

INPP5B AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.68e-0745905MM1173
CoexpressionLIN_TUMOR_ESCAPE_FROM_IMMUNE_ATTACK

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.31e-0624904MM766
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_C_DN

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.56e-0625904MM480
CoexpressionMARSON_FOXP3_TARGETS_DN

AKR1C3 RIOX1 AKR1C4 AKR1C1 AKR1C2

2.01e-0660905MM847
CoexpressionBYSTRYKH_HEMATOPOIESIS_STEM_CELL_SCP2_QTL_TRANS

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.33e-0630904MM853
CoexpressionDESCARTES_ORGANOGENESIS_INTERMEDIATE_MESODERM

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.04e-0636904MM3660
CoexpressionWANG_IMMORTALIZED_BY_HOXA9_AND_MEIS1_UP

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.87e-0637904MM630
CoexpressionZAMORA_NOS2_TARGETS_DN

AP1B1 AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.41e-0589905MM690
CoexpressionYAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_6

DSP AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.73e-05102905MM872
CoexpressionGAO_ESOPHAGUS_25W_C1_CILIATED_EPITHELIAL_CELLS

DCDC2 ABCB10 INPP5B SYNE1 CFAP61 DNAH5 BAIAP3 CCDC33 DNAH11

2.89e-05459909M39136
CoexpressionKINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP

KNTC1 DCDC2 ILF3 UBE2G2 ABCB10 TMTC3 FARSB PDS5A APPL1 PRKDC CDK1 ZW10 CNOT1 HELLS XPO7

3.15e-0512909015M80
CoexpressionWOOD_EBV_EBNA1_TARGETS_UP

ILF3 TMPRSS3 AKR1C3 AKR1C1 AKR1C2

3.93e-05110905M1696
CoexpressionNADLER_HYPERGLYCEMIA_AT_OBESITY

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.96e-0566904MM631
CoexpressionPETROVA_PROX1_TARGETS_UP

DSP CDK1 BTBD3

8.52e-0525903M1495
CoexpressionPATIL_LIVER_CANCER

KNTC1 ILF3 ABCB10 TRIO DSP AKR1C3 PRKDC CDK1 HELLS XPO7

8.95e-056609010M1195
CoexpressionGOLDRATH_IMMUNE_MEMORY

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.47e-0569904MM621
CoexpressionRAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP

CIP2A AKR1C3 AKR1C4 AKR1C1 AKR1C2 HELLS

1.10e-04219906MM1237
CoexpressionBREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_UP

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.24e-0474904MM769
CoexpressionSHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM3

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.60e-0479904MM535
CoexpressionGRYDER_PAX3FOXO1_ENHANCERS_IN_TADS

UBE2G2 AP1B1 TRIO SACS SLC16A2 COX16 SVIL FARSB APPL1 ZW10 HELLS XPO7

1.71e-0410099012M157
CoexpressionHOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_DN

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.13e-0485904MM802
ToppCellP07-Epithelial-airway_epithelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ENO4 DCDC2 CFAP61 DNAH5 AK7 CCDC33 DNAH11

9.58e-08184907a5e7af3392e9d6ddad0397f1eeb6b91ed1107cc2
ToppCellP07-Epithelial-airway_epithelial_cell-club_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ENO4 DCDC2 CFAP61 DNAH5 AK7 CCDC33 DNAH11

9.58e-08184907ab469b9e06212462cbe2e4db8775c6778db855e6
ToppCellP28-Epithelial-airway_epithelial_cell-club_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ENO4 DCDC2 CFAP61 DNAH5 AK7 CCDC33 DNAH11

1.03e-07186907a26811481668fa25c48a064a56c198685693ad8d
ToppCellP28-Epithelial-airway_epithelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ENO4 DCDC2 CFAP61 DNAH5 AK7 CCDC33 DNAH11

1.03e-07186907df80f101954b8ec6ccdb03e702de22e70b65181f
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENO4 DCDC2 CFAP61 DNAH5 AK7 CCDC33 DNAH11

1.23e-07191907649fcb62ad15de2f83e61591e43923a717664ae7
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENO4 DCDC2 CFAP61 DNAH5 AK7 CCDC33 DNAH11

1.23e-071919079621e22e14ea069f22713947c9faa2d882abe5fe
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENO4 DCDC2 CFAP61 DNAH5 AK7 CCDC33 DNAH11

1.23e-071919076a8fc9dc1a4c7115862e8f20204fa2f95e50e22f
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-10|TCGA-Brain / Sample_Type by Project: Shred V9

ENO4 DCDC2 CFAP61 DNAH5 AK7 CCDC33

1.32e-0617190674be8d3bf6b99e2d734635a8b1a7c41e8c596959
ToppCellP03-Epithelial-airway_epithelial_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ENO4 DCDC2 CFAP61 DNAH5 AK7 CCDC33

1.84e-061819061ea21d860d4d7abab3e21e130a16d044006656ee
ToppCellP03-Epithelial-airway_epithelial_cell-club_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ENO4 DCDC2 CFAP61 DNAH5 AK7 CCDC33

1.84e-0618190660a91587c59029a34e7bec1255083337fe21b72a
ToppCelldroplet-Lung-LUNG-30m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENO4 DCDC2 DNAH5 TMC3 AK7 CCDC33

1.96e-061839063991830726d05cf19606d540de04093985b7bdeb
ToppCelldroplet-Lung-LUNG-30m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENO4 DCDC2 DNAH5 TMC3 AK7 CCDC33

1.96e-06183906cc844f54c7564bf432b179ca63bc7c4b9b8cfdd9
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENO4 DCDC2 DNAH5 AK7 CCDC33 DNAH11

2.22e-0618790604dba2ed09ee4180830bdf0191921696697ea234
ToppCellP15-Epithelial-airway_epithelial_cell-club_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ENO4 DCDC2 CFAP61 DNAH5 TMC3 AK7

2.22e-06187906a70aaae32426e9ddb1cbfbd0e0db24ccc96b9f40
ToppCellfacs-Lung-EPCAM-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENO4 DCDC2 DNAH5 AK7 CCDC33 DNAH11

2.22e-06187906805dafe22f835ece4dd091d8030d0a63b52a48dd
ToppCellP15-Epithelial-airway_epithelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ENO4 DCDC2 CFAP61 DNAH5 TMC3 AK7

2.29e-06188906e3e71c0f2e374330620cb4d27638953ffa9f5298
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENO4 DCDC2 CFAP61 DNAH5 AK7 CCDC33

2.43e-061909069ffd18ef358f8e32c610ab6420f479067c8ba44b
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENO4 DCDC2 CFAP61 DNAH5 AK7 CCDC33

2.43e-061909063ef39d61c98de4e5df946b995847aa65eba6a4b6
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTP4A2 DSP MSL3 PDS5A BTBD3 ITPR2

2.51e-0619190660c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTP4A2 DSP MSL3 PDS5A BTBD3 ITPR2

2.51e-06191906973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellCiliated-cil-3|World / Class top

SYNE1 CFAP61 DNAH5 AK7 CCDC33 DNAH11

2.58e-061929064989ebb8812b8af1870599acd932849122c05a29
ToppCellPCW_10-12-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DCDC2 DSP LIPH MTTP ADGRV1 DNAH5

2.66e-06193906b25cdca3a1e381784ae48ca73c51cbb6ac62b811
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DSP SVIL SAMD5 AKR1C3 AKR1C1 PREX2

2.66e-061939063f8280ef849d95b2fcea5e6824b95a07febc96d0
ToppCell(05)_Ciliated|World / shred by cell type and Timepoint

ENO4 SYNE1 CFAP61 DNAH5 AK7 CCDC33

2.99e-06197906fee3cd16af8eea697cd64e8f64af505aaa2ac4b0
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial-Airway-Club|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ENO4 TMPRSS3 AKR1C3 CFAP61 AKR1C1 CCDC33

3.08e-061989066712216c5a7fd86b68fd45b0ff7794975f19774e
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

TMPRSS3 AKR1C3 DNAH5 AKR1C1 AK7 CCDC33

3.17e-0619990660919c2af31d39a2d36d7bc432e43dab2a4e05fb
ToppCellLPS_anti-TNF-Epithelial_airway|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

TMPRSS3 AKR1C3 DNAH5 AKR1C1 AK7 CCDC33

3.17e-061999066aca164bbbb961f34b1e6f1857f91ade5c059405
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP61 DNAH5 BAIAP3 AK7 CCDC33 DNAH11

3.27e-0620090652aef65f01b06cd98056f17977efe525aee6eb6f
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP61 DNAH5 BAIAP3 AK7 CCDC33 DNAH11

3.27e-0620090655c148238d5c80c1faa3428a917ae8075be2c145
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-Cilia-bearing_cell|6m / Sample Type, Dataset, Time_group, and Cell type.

ENO4 DCDC2 DNAH5 AK7 CCDC33 DNAH11

3.27e-06200906177f9ad8dd8635394c575a2b30140184df0bd51e
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ELMO3 DSP SAMD5 TMEM225B HELLS

3.54e-06114905b350140b389f8762c77a37df473081e1127a8972
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP61 DNAH5 AK7 CCDC33 DNAH11

1.39e-0515190581cf939ed4df9574fbfff265e109cb9f947d7e6e
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP61 DNAH5 AK7 CCDC33 DNAH11

1.39e-051519059cbcbbc22965a9f0be8364e733d205dd64f2a533
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP61 DNAH5 AK7 CCDC33 DNAH11

1.53e-051549054e3bc24043144143842627cacf6f90dda2228910
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP61 DNAH5 AK7 CCDC33 DNAH11

1.53e-051549057556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP61 DNAH5 AK7 CCDC33 DNAH11

1.58e-051559055f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP61 DNAH5 AK7 CCDC33 DNAH11

1.58e-051559050944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LIPH TMPRSS3 COX10 AKR1C1 ABHD16A

2.07e-05164905c5bfae7e9497185548c243d6f9ebadbcef48ba7f
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LIPH TMPRSS3 COX10 AKR1C1 ABHD16A

2.07e-0516490576b0ac220b7ca22fbea28a507f01f96ae9f53932
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LIPH TMPRSS3 COX10 AKR1C1 ABHD16A

2.07e-05164905911081739174ec68bc0893c804e4276b206bea7d
ToppCellLPS_only-Epithelial_airway|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DSP TMPRSS3 DNAH5 AKR1C1 CCDC33

2.07e-0516490556e6934e6c7503a300d7be06762d45a1d6f1ae0f
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-Klrb1a/b/c(-)_NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD6 SYNE1 APLP1 HERC3 BAIAP3

2.13e-05165905eeb58d4db64ad37dc6b441eab22b05c24862e1a9
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

UBE2G2 CPSF1 DISP2 PREX2 HELLS

2.13e-0516590562457b7b74c6eae42d91d65e7dc6df6bf8e061f7
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-Th1|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA2D4 CD6 TMPRSS3 ZBTB4 LCP2

2.26e-051679059c55ec8f70b86d4d3d5c2a6ecd9bff2dafe68c11
ToppCelldroplet-Fat-Gat-18m-Epithelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENO4 DCDC2 DNAH5 AK7 DNAH11

2.68e-05173905f3f67531f72d6d52e19c7f1f2db1ab4026fb70da
ToppCelldroplet-Fat-Gat-18m-Epithelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENO4 DCDC2 DNAH5 AK7 DNAH11

2.68e-05173905a40a52d8041d45dc3bef74fe55945ae07aa018d6
ToppCelldroplet-Fat-Gat-18m-Epithelial-epithelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENO4 DCDC2 DNAH5 AK7 DNAH11

2.68e-05173905f0b4dd1cf41d6ee6abb0e1968b8b39f4fabebcb5
ToppCellfacs-Trachea-nan-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DCDC2 DNAH5 AK7 CCDC33 DNAH11

2.91e-05176905ed788a5969edfd1199828ca5b0dd34e7f29c4d30
ToppCellfacs-Skin-Anagen-24m-Epithelial-actively_dividing_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENO4 KNTC1 CIP2A CDK1 VAV2

2.99e-051779058a0f0fbb06cdacb99a3fdba0da3e0494b891db4f
ToppCelldroplet-Lung-LUNG-30m-Epithelial-club_cell_of_bronchiole|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DCDC2 DSP DNAH5 AK7 CCDC33

2.99e-051779057ac99ff16df94b4e08d361e3d98a7b3af8d6ee3b
ToppCellfacs-Skin-Anagen-24m-Epithelial-keratinocyte_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENO4 KNTC1 CIP2A CDK1 VAV2

2.99e-05177905e9d7682517fb30fd2ad535d59779d718a7024c13
ToppCelldroplet-Lung-21m-Epithelial-airway_epithelial-lung_ciliated_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DCDC2 LIPH DNAH5 AK7 CCDC33

2.99e-05177905d947ba38db1772fc5fdcdc211f7511c4aa699dee
ToppCelldroplet-Lung-LUNG-30m-Epithelial-Club_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DCDC2 DSP DNAH5 AK7 CCDC33

2.99e-05177905092a345cb802f183322aa5542341ba2d96d4f06a
ToppCelldroplet-Lung-21m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DCDC2 LIPH DNAH5 AK7 CCDC33

2.99e-05177905d5640f0097878f0dac671e51dc51310278bb2682
ToppCellfacs-Trachea-18m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell-ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DCDC2 DNAH5 AK7 CCDC33 DNAH11

3.15e-05179905d4efbc34f52136039b96451fd0b0a0ad164197c6
ToppCellfacs-Trachea-18m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DCDC2 DNAH5 AK7 CCDC33 DNAH11

3.15e-051799058a66d197a2f55d763ff7ef0bec89ee96f59c3937
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 CIP2A PRKDC CDK1 HELLS

3.15e-0517990588d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCellE18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENO4 DCDC2 DNAH5 AK7 CCDC33

3.59e-05184905797b6a6d6f6aafae98f75ca8bffe8263f8d3ff9b
ToppCellE18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENO4 DCDC2 DNAH5 AK7 CCDC33

3.59e-0518490577d5b60a20b277f589b18f7a131142a7ef2dac17
ToppCellControl-Myeloid-Macrophage_Alveolar|World / Disease state, Lineage and Cell class

SVIL MCF2L2 AKR1C3 AKR1C1 AKR1C2

3.69e-0518590585cb81759589a26d83676cffbf2bc37399683c10
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH5 BAIAP3 AK7 CCDC33 DNAH11

3.69e-051859055e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell15-Airway-Epithelial-Multiciliated_cell|Airway / Age, Tissue, Lineage and Cell class

CFAP61 DNAH5 AK7 CCDC33 DNAH11

3.69e-051859050998b6bf44287eebbf39249fff23fc3689e44c4e
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH5 BAIAP3 AK7 CCDC33 DNAH11

3.78e-0518690576033438426d8f9c72cd6691a7baf92104c9f03d
ToppCelldroplet-Lung-nan-18m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENO4 DCDC2 DNAH5 AK7 CCDC33

3.78e-05186905740fd06bcd3b24e6ff2ecf8080f378afc3e95084
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-Microfold_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DCDC2 PDILT AKR1C3 AKR1C1 AKR1C2

3.78e-051869056d8dd6d0403d149cb6edb346581fe6c248036785
ToppCelldroplet-Lung-nan-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENO4 DCDC2 DNAH5 AK7 CCDC33

3.78e-051869055ab43a298d23238b34e898d11decf0ad81d1b14e
ToppCellfacs-MAT-Fat-3m-Epithelial-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NDST3 APLP1 ADGRV1 DNAH11

3.82e-0593904dbfaa7f23d25f5c286ab7ca3ca795b734cb95153
ToppCellfacs-MAT-Fat-3m-Epithelial-epithelial_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NDST3 APLP1 ADGRV1 DNAH11

3.82e-05939040d6d1d8dd9c91ba31eb35a4b5979d087890936c1
ToppCellfacs-MAT-Fat-3m-Epithelial|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NDST3 APLP1 ADGRV1 DNAH11

3.82e-0593904abffb1fd5a919b7c08e62e1c3c08a8dd8783a4ca
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENO4 DCDC2 DNAH5 AK7 DNAH11

3.88e-051879051bba994aaaa9825b54aaeaff3829850267bc4602
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 CIP2A TLR2 CDK1 LCP2

3.88e-0518790573931a5ea73799095daff100b5f18853c57c74dc
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENO4 DCDC2 DNAH5 AK7 DNAH11

3.88e-05187905d6ac351e7aeba98851d308c14ac395044fe4fbbb
ToppCelldroplet-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENO4 DCDC2 DNAH5 AK7 CCDC33

3.98e-051889050eca3dc93724e23b71e687fc24fa9f1e89bdef6a
ToppCelldroplet-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENO4 DCDC2 DNAH5 AK7 CCDC33

3.98e-051889059ce3e1fffce87ad19812ecbf9b7f9935a975d676
ToppCellPND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENO4 DCDC2 DNAH5 AK7 CCDC33

4.08e-05189905057d7a03fdbe779122b203619a6f947f49b84d28
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENO4 DCDC2 CFAP61 DNAH5 AK7

4.08e-05189905b55de812043b670cbde810d7d42f45909b6d66ef
ToppCellPND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENO4 DCDC2 DNAH5 AK7 DNAH11

4.08e-0518990502c6128a9ab5818e0881dcadafdad5f08b9a67cf
ToppCellPND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENO4 DCDC2 DNAH5 AK7 DNAH11

4.08e-05189905164ea92ff6a1aa2ead1c9b8f64f99a9d65437232
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DCDC2 TRIO SVIL ADGRV1 DNAH5

4.08e-051899058c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCellPND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENO4 DCDC2 DNAH5 AK7 CCDC33

4.08e-051899059f57a131902d23494bf389baf6e6e2d99f88b2c8
ToppCelldroplet-Lung-18m-Epithelial-airway_epithelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENO4 DCDC2 DNAH5 AK7 CCDC33

4.08e-05189905fe958fdf9963c2dfe270f67f0da36b3264d0017c
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DCDC2 TRIO SVIL ADGRV1 DNAH5

4.08e-051899055d902a4660a27548764bf04c6de152b565da835c
ToppCellPND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENO4 DCDC2 DNAH5 AK7 DNAH11

4.08e-05189905a85099bd598a27ee64ee0664d051d89fa8d62fc9
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

CFAP61 DNAH5 AK7 CCDC33 DNAH11

4.08e-0518990527329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENO4 DCDC2 CFAP61 DNAH5 AK7

4.08e-051899054e83e49d1265ffe507fdb72924c77c4d1c73f0bd
ToppCellPND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ENO4 DCDC2 DNAH5 AK7 CCDC33

4.08e-05189905e443b02502edaefa94567a9e8af5756e8e11ff30
ToppCellfacs-Lung-nan-3m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENO4 DCDC2 CFAP61 DNAH5 AK7

4.19e-05190905e243b5fbb17b9ec3cc90bbe970c1d30b0fd1c2e1
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KNTC1 CD6 CDK1 BAIAP3 HELLS

4.19e-05190905f5a8b44d9948a16e2d5284c78d8f7ed422ac623a
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LIPH SYNE1 AKR1C1 AKR1C2 DNAH11

4.19e-05190905a5db902ad112a0c0a0a7f1a2e38718bb3bd11412
ToppCellfacs-Lung-nan-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENO4 DCDC2 CFAP61 DNAH5 AK7

4.19e-05190905fe844559b95832845d2e8d3ab4b57e3d558bc372
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-Proliferating_T_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KNTC1 CD6 CDK1 BAIAP3 HELLS

4.19e-0519090508420f0ecd2c62e102371d16dcb8eda0d510e92a
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DCDC2 TRIO LIPH DNAH5 AKR1C1

4.29e-05191905d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellCOVID-19-kidney-Proliferating_T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

KNTC1 CD6 CIP2A CDK1 HELLS

4.29e-05191905bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTP4A2 DSP MSL3 PDS5A BTBD3

4.29e-0519190509db184cb90fe282a14474d7217068c58092c6f8
ToppCellPCW_13-14-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DCDC2 DSP LIPH ADGRV1 DNAH5

4.51e-05193905b38aaffbea36ef6c08ebe82675438f873c89b242
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

SYNE1 CFAP61 DNAH5 AK7 DNAH11

4.51e-05193905ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SLC43A2 AP1B1 TLR2 LCP2 ITPR2

4.62e-05194905663e7e7fe48157e808b4f1a0ea6ad41944e857a2
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DCDC2 DSP MTTP ADGRV1 DNAH5

4.62e-05194905f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

LIPH SYNE1 DNAH5 AK7 DNAH11

4.74e-05195905fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

KNTC1 CIP2A PRKDC CDK1 HELLS

4.74e-05195905cec7df321f372d05c94f97d6bb18891a5cc3dec3
Drugcloxazolam

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.28e-104904ctd:C005522
DrugPregnanes

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.28e-104904ctd:D011278
Drugtetralol

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.28e-104904ctd:C019106
Drug3',3'',5',5''-tetrabromophenolphthalein

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.28e-104904ctd:C018156
DrugHydroxysteroids

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.14e-095904ctd:D006914
Drugcresolphthalein

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.14e-095904ctd:C010092
DrugMeclofenamic Acid

SLC16A2 AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.68e-0914905ctd:D008469
DrugMedazepam

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.40e-096904ctd:D008472
DrugNitrazepam

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.58e-088904ctd:D009567
Drug4-hydroxybenzoic acid

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.83e-089904ctd:C038193
Drug20-alpha-Dihydroprogesterone

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.83e-089904ctd:D004092
Drugoctyl gallate

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.71e-0810904ctd:C016627
Drugcyclopentanol

AKR1C3 AKR1C1 AKR1C2

5.97e-083903ctd:C016327
Drugcyclopentanone

AKR1C3 AKR1C1 AKR1C2

5.97e-083903ctd:C007201
Drug5-dihydrodeoxycorticosterone

AKR1C4 AKR1C1 AKR1C2

5.97e-083903ctd:C454687
Drug4-benzoylbenzoic acid

AKR1C3 AKR1C1 AKR1C2

5.97e-083903ctd:C058818
Drugdichloro(4-cymene)ruthenium(II)

AKR1C3 AKR1C1 AKR1C2

5.97e-083903ctd:C530610
DrugDihydroxydihydrobenzopyrenes

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.38e-0811904ctd:D004101
Drugchlordecone alcohol

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.38e-0811904CID000013946
DrugPhenolphthalein

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.10e-0712904ctd:D020113
DrugDMBA-3,4-dihydrodiol

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.59e-0713904CID000050096
Drugflunisolide

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.59e-0713904ctd:C007734
Drug5-alpha-Dihydroprogesterone

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.22e-0714904ctd:D043582
Drug1-acenaphthenol

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.22e-0714904CID000022750
Drugtetrahydrodeoxycorticosterone

AKR1C4 AKR1C1 AKR1C2

2.38e-074903ctd:C009413
Druggliquidone

AKR1C3 AKR1C1 AKR1C2

2.38e-074903ctd:C010969
DrugDBD-H

AKR1C3 AKR1C4 AKR1C1

2.38e-074903CID000131382
DrugNSC86000

AKR1C3 AKR1C1 AKR1C2

5.94e-075903CID000257630
Drugoxcarbazepine

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.46e-0719904ctd:C036006
Drugbenzo(a)pyrene-7,8-dione

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.05e-0620904ctd:C076588
DrugChrysenes

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.05e-0620904ctd:D002911
DrugAC1L93E5

AKR1C3 AKR1C4 AKR1C1

1.18e-066903CID000412383
DrugEstazolam

AKR1C3 AKR1C1 AKR1C2

1.18e-066903ctd:D004949
Drug3-hydroxyhexobarbital

AKR1C3 AKR1C4 AKR1C2

1.18e-066903CID000439898
DrugGlipizide

AKR1C3 AKR1C1 AKR1C2

1.18e-066903ctd:D005913
Drugacenaphthene-1-ol

AKR1C3 AKR1C1 AKR1C2

1.18e-066903ctd:C023723
DrugFlunitrazepam

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.30e-0621904ctd:D005445
Drugbenzene dihydrodiol

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.58e-0622904CID000000418
Drug4-hydroxyequilenin-o-quinone

AKR1C3 AKR1C1 AKR1C2

2.07e-067903ctd:C117714
Drugzomepirac

AKR1C3 AKR1C1 AKR1C2

2.07e-067903ctd:C020549
DrugGlycyrrhetinic Acid

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.28e-0624904ctd:D006034
DrugHexestrol

SVIL AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.57e-0655905ctd:D006589
Drug9,10-phenanthrenequinone

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.71e-0625904ctd:C005399
DrugPregnanolone

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.71e-0625904ctd:D011280
Drug2-cyclohexen-1-ol

AKR1C3 AKR1C4 AKR1C2

3.30e-068903CID000013198
Drugbenzo(a)pyrene 7,8-dihydrodiol

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.62e-0631904ctd:C017228
Drugfenamic acid

AKR1C3 AKR1C1 AKR1C2

1.28e-0512903ctd:C001209
DrugDB07444

AOX1 APPL1 AKR1C2

1.28e-0512903CID006540255
DrugSotalol hydrochloride [959-24-0]; Down 200; 13uM; MCF7; HT_HG-U133A

MED15 INPP5B SVIL AOX1 MSL3 C15orf39 XPO7

1.42e-051999077338_DN
Drugalpha-methylcinnamic acid

AKR1C3 AKR1C1

1.55e-052902ctd:C510582
Drug(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE

AKR1C1 AKR1C2

1.55e-052902DB07768
Drugbaccharin

AKR1C3 AKR1C2

1.55e-052902ctd:C012764
Drug4-formyl-benzoate

AKR1C4 AKR1C1 AKR1C2

1.66e-0513903CID000012088
Drug20 alpha-dihydroprogesterone

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.87e-0540904CID000008956
Drugaa 2

DSP SYNE1 AKR1C1 AKR1C2

2.07e-0541904CID000447622
Drugo-quinone

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.07e-0541904CID000011421
DrugDydrogesterone

AKR1C3 AKR1C1 AKR1C2

2.11e-0514903ctd:D004394
Drug6-.beta.-Naltrexol

AKR1C4 AKR1C1 AKR1C2

2.11e-0514903CID000631219
Drugandrosterone glucuronide

AOX1 AKR1C3 AKR1C1 AKR1C2

2.50e-0543904CID000114833
Drugdrospirenone

AKR1C4 AKR1C1 AKR1C2

2.63e-0515903ctd:C035144
DrugFlufenamic Acid

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.00e-0545904ctd:D005439
Drugnaphthalene-1,2-dihydrodiol

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.00e-0545904CID000000362
Drug9-cis-retinal

AKR1C3 AKR1C4 AKR1C1

3.22e-0516903ctd:C031390
Drugbenzo(a)pyrene-1,6-quinone

AKR1C3 AKR1C1 AKR1C2

3.90e-0517903ctd:C030233
DrugXK469

SYNE1 AOX1 CDK1

3.90e-0517903CID000148183
DrugNSC55

AOX1 APPL1

4.62e-053902CID000012116
Drugcloxazolam

AKR1C3 AKR1C1 AKR1C2

4.67e-0518903CID000002816
DrugRuthenium Compounds

AKR1C3 AKR1C1 AKR1C2

4.67e-0518903ctd:D017975
Drugbenzo(a)pyrene-3,6-quinone

AKR1C3 AKR1C1 AKR1C2

4.67e-0518903ctd:C018003
Drug1 C2

PLEKHG4 AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.83e-05100905CID005327152
Drugandrostane-3,17-dione

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.95e-0551904CID000000443
Drug3-hydroxyandrostan-17-one

PTP4A2 AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.31e-05102905CID000000225
DrugAC1L8ZBW

AKR1C4 AKR1C1 AKR1C2

5.53e-0519903CID000435356
Drugconiferaldehyde

AKR1C3 AKR1C1 AKR1C2

7.54e-0521903ctd:C075384
DrugDutasteride

AKR1C3 AKR1C1 AKR1C2

7.54e-0521903ctd:D000068538
Drug1,2-dihydroxynaphthalene

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.68e-0557904CID000011318
Drugphenolphthalein

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.23e-0558904CID000004764
DrugNSC36919

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.23e-0558904CID000235496
Drugmethiin

SACS MTOR

9.22e-054902CID000082142
Druggamma-terpineol

PTP4A2 CD6

9.22e-054902CID000011467
DrugSanguinarine [2447-54-3]; Down 200; 12uM; HL60; HT_HG-U133A

UBE2G2 SACS INPP5B PDS5A APPL1 PRKDC

9.38e-051859062927_DN
Drug2-carboxybenzaldehyde

APPL1 AKR1C4 AKR1C1

9.99e-0523903CID000008406
Drug2'-Monophosphoadenosine 5'-Diphosphoribose

AKR1C3 AKR1C1 AKR1C2

9.99e-0523903DB03461
Drug9,10-phenanthrenequinone

MTTP AKR1C3 AKR1C4 AKR1C1

1.00e-0461904CID000006763
Drugmedazepam

AKR1C3 AKR1C1 AKR1C2

1.14e-0424903CID000004041
DrugCeforanide [60925-61-3]; Down 200; 7.6uM; PC3; HT_HG-U133A

MED15 ILF3 CD6 INPP5B PRKDC ITPR2

1.18e-041939066751_DN
Drugisoeugenol

TLR2 AKR1C3 AKR1C1 AKR1C2

1.21e-0464904ctd:C036643
DrugMidodrine hydrochloride [3092-17-9]; Down 200; 13.8uM; PC3; HT_HG-U133A

MED15 AP2B1 TRIO CNGB3 C15orf39 XPO7

1.22e-041949062087_DN
DrugNeostigmine bromide [114-80-7]; Up 200; 13.2uM; MCF7; HT_HG-U133A

AP2B1 SYNE1 MC2R PEX11A ECPAS ITPR2

1.25e-041959063294_UP
DrugSulmazole [73384-60-8]; Up 200; 14uM; MCF7; HT_HG-U133A

KCNJ3 SYNE1 CNGB3 PEX11A BAIAP3 VAV2

1.29e-041969064127_UP
DrugDequalinium dichloride [522-51-0]; Up 200; 7.6uM; MCF7; HT_HG-U133A

NDST3 AP2B1 TRIO ECPAS BAIAP3 PREX2

1.29e-041969062631_UP
DrugClorsulon [60200-06-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A

MED15 TLR2 C15orf39 APLP1 ECPAS ITPR2

1.29e-041969062884_UP
DrugR(+)-verapamil hydrochloride; Down 200; 10uM; MCF7; HG-U133A

ILF3 TRIO CPSF1 C15orf39 PDS5A CDK1

1.32e-04197906164_DN
DrugAceclofenac [89796-99-6]; Up 200; 11.2uM; PC3; HT_HG-U133A

MED15 UBE2G2 AP2B1 INPP5B TLR2 HERC3

1.32e-041979062117_UP
DrugLomefloxacin hydrochloride [98079-52-8]; Down 200; 10.4uM; PC3; HT_HG-U133A

AP2B1 TRIO INPP5B SVIL ZW10 ITPR2

1.32e-041979063723_DN
DrugIsradipine [75695-93-1]; Up 200; 10.8uM; PC3; HT_HG-U133A

CD6 CNGB3 PDS5A AKR1C4 PEX11A BAIAP3

1.36e-041989066347_UP
Drugtamoxifen citrate; Down 200; 1uM; MCF7; HG-U133A

CD6 COX16 MTOR KCNJ3 HERC3 LCP2

1.40e-04199906380_DN
Drugchlordecone

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.45e-0467904CID000000299
Drugglycolithocholic acid

AKR1C3 AKR1C4 AKR1C2

1.45e-0426903CID000115245
DrugV-X-R

DSP PHC2

1.53e-045902CID011957413
DiseaseNeoplasms, Hormone-Dependent

AKR1C3 AKR1C1 AKR1C2

2.74e-083903C0027661
DiseaseHermaphroditism

AKR1C3 AKR1C1 AKR1C2

2.73e-075903C0019269
DiseaseAmbiguous Genitalia

AKR1C3 AKR1C1 AKR1C2

2.73e-075903C0266362
DiseasePseudohermaphroditism

AKR1C3 AKR1C1 AKR1C2

2.73e-075903C0033804
DiseaseIntersex Conditions

AKR1C3 AKR1C1 AKR1C2

2.73e-075903C2930618
DiseaseSex Differentiation Disorders

AKR1C3 AKR1C1 AKR1C2

2.73e-075903C2930619
DiseaseDisorders of Sex Development

AKR1C3 AKR1C1 AKR1C2

9.52e-077903C0036875
DiseaseMALE PSEUDOHERMAPHRODITISM: DEFICIENCY OF TESTICULAR 17,20-DESMOLASE

AKR1C4 AKR1C2

9.20e-062902C1839840
Disease46,XY disorder of sex development due to testicular 17,20-desmolase deficiency

AKR1C4 AKR1C2

9.20e-062902cv:C1839840
Disease46,XY sex reversal 8 (is_implicated_in)

AKR1C4 AKR1C2

9.20e-062902DOID:0111773 (is_implicated_in)
Disease46,XY SEX REVERSAL 8

AKR1C4 AKR1C2

9.20e-062902614279
DiseaseKartagener syndrome (implicated_via_orthology)

AP1B1 DNAH5 DNAH11

9.75e-0614903DOID:0050144 (implicated_via_orthology)
DiseaseKartagener syndrome (is_implicated_in)

DNAH5 DNAH11

5.50e-054902DOID:0050144 (is_implicated_in)
Diseasephosphatidylcholine 38:4 measurement

ADGRV1 MUSK ITPR2

8.51e-0528903EFO_0010386
Diseaseresponse to bevacizumab, Proteinuria

TRIO DNAH5

9.15e-055902EFO_0005943, HP_0000093
Diseaseprocollagen C-endopeptidase enhancer 1 measurement

MUSK DNAH11

1.37e-046902EFO_0801920
Diseasecortolone glucuronide (1) measurement

AKR1C3 AKR1C2

1.37e-046902EFO_0800552
Diseasevisceral heterotaxy (implicated_via_orthology)

AP1B1 DNAH5 DNAH11

1.98e-0437903DOID:0050545 (implicated_via_orthology)
Diseasechemotherapy-induced alopecia, methylcobalamin deficiency type cblE

TRIO DNAH5

2.55e-048902EFO_0005400, MONDO_0009354
Diseasealcohol consumption measurement

NDST3 MTOR KCNJ3 MTTP FARSB ADGRV1 ZW10 DNAH5 BTBD3 PHC2 CCDC33 XPO7

3.88e-0412429012EFO_0007878
DiseaseIntellectual Disability

AP1B1 TRIO SACS MTOR SYNE1 MSL3 FARSB

4.43e-04447907C3714756
DiseaseMetastatic melanoma

TRIO MTOR PRKDC

6.08e-0454903C0278883
DiseaseSclerocystic Ovaries

AKR1C3 AKR1C1 AKR1C2 HELLS

1.00e-03144904C1136382
DiseasePolycystic Ovary Syndrome

AKR1C3 AKR1C1 AKR1C2 HELLS

1.00e-03144904C0032460
Diseasemaximal oxygen uptake measurement, response to exercise

SLC43A2 SAMD5

1.07e-0316902EFO_0004887, EFO_0007768
Diseaseresponse to methotrexate

AKR1C1 AKR1C2

1.07e-0316902GO_0031427
DiseaseColorectal Carcinoma

NDST3 ABCB10 SACS SYNE1 PDILT TLR2 MCF2L2 PREX2

1.38e-03702908C0009402
Diseasecytochrome-c oxidase deficiency disease (is_implicated_in)

COX16 COX10

1.52e-0319902DOID:3762 (is_implicated_in)
Diseaseprimary ciliary dyskinesia (implicated_via_orthology)

AP1B1 DNAH5

1.52e-0319902DOID:9562 (implicated_via_orthology)
Diseaseselenium measurement, response to dietary selenium supplementation

TRIO DNAH5

1.69e-0320902EFO_0006331, EFO_0600021
DiseaseLung diseases

PRKDC DNAH5 DNAH11

1.77e-0378903C0024115
DiseaseNonsyndromic Deafness

DCDC2 TMPRSS3 ADGRV1

1.97e-0381903C3711374
DiseaseBronchiectasis

DNAH5 DNAH11

2.04e-0322902C0006267
Diseasetriacylglycerol 54:8 measurement

CACNA2D4 SLC35B3

2.23e-0323902EFO_0010426
DiseaseDyslipidemias

PEX11A DNAH11

2.43e-0324902C0242339
Diseasechildhood trauma measurement

NDST3 SAMD5

2.43e-0324902EFO_0007979
DiseaseDyslipoproteinemias

PEX11A DNAH11

2.43e-0324902C0598784
Diseaseforced expiratory volume, response to bronchodilator

SYNE1 SLC35B3 HERC3 ADGRV1 DNAH5 BTBD3

2.44e-03445906EFO_0004314, GO_0097366
DiseaseLiver Cirrhosis, Experimental

SLC43A2 ZBTB4 AKR1C3 APPL1 CDK1 LCP2 AKR1C1 HELLS

2.53e-03774908C0023893
Diseasediacylglycerol 34:2 measurement

CACNA2D4 MUSK

2.64e-0325902EFO_0010353
Diseaseresponse to norepinephrine-dopamine reuptake inhibitor

ADGRV1 AK7

2.85e-0326902EFO_0007870

Protein segments in the cluster

PeptideGeneStartEntry
RQLEMILNKPGLKYK

AKR1C4

171

P17516
RILSDLNLVMYPKLG

CAPZA3

271

Q96KX2
ANLDRLIPMYKGAKI

CFAP61

1026

Q8NHU2
PIYVKLEKLDIMIRL

AP2B1

331

P63010
VLPLKSRLYQKMLTG

CCDC33

516

Q8N5R6
VAPLMKYLDEKLALL

BAIAP3

891

O94812
RQLEMILNKPGLKYK

AKR1C3

171

P42330
MAKLLSCVLGPRLYK

ABHD16A

1

O95870
IIRLKGLMGKVLVSY

ADGRV1

2001

Q8WXG9
IVLSMLLLRRKKPYG

APLP1

596

P51693
MKLQVYDLPGILARL

COX10

146

Q12887
RLRYFMELLLEKGKP

DNAH11

2491

Q96DT5
EELLSKPNGIYRKLM

ABCB10

716

Q9NRK6
KVLGKALYLIRIPTM

BTBD3

311

Q9Y2F9
NLRKLFDKLLEYMPL

API5

306

Q9BZZ5
PIYVKLEKLDIMIRL

AP1B1

331

Q10567
RKNKTLGYGVPMLLL

COX16

11

Q9P0S2
LMLPATVLLYRKLGI

DISP2

1076

A7MBM2
MLLPYLRKKLRLTGT

AOX1

26

Q06278
FPFLIRMLGDKIKLA

SLC16A2

246

P36021
DLPVLIDKMKGKYIL

NDST3

116

O95803
LHKALVKLLLPLEYM

PDS5A

936

Q29RF7
INPLGKYRMDLVLQL

ITPR2

2026

Q14571
FILLRIKGKYALPVM

CD6

421

P30203
FLILDRMLPELKKRG

HELLS

601

Q9NRZ9
FLLLLKELLNPIYGM

HERC3

751

Q15034
LGIVMDKYGPRKLRL

SLC43A2

106

Q8N370
KKKIALLEPLLGYMQ

APPL1

191

Q9UKG1
GLLLPMQEKTYRRLL

CPSF1

1346

Q10570
PMLLNGLTKLINEYK

ECPAS

396

Q5VYK3
SQRLIKYQMLLKGLL

MCF2L2

756

Q86YR7
RMYLLALKNALLPEG

MTTP

471

P55157
LLRLFVKLPEILGKM

MSL3

456

Q8N5Y2
LKQLSKYIEPLRRMI

MED15

536

Q96RN5
LLGFNMIPYLRKVLK

KNTC1

1986

P50748
LIGPRYKLRILRMKL

LIPH

401

Q8WWY8
LELLLMNRYVKPGLK

ANKRD49

191

Q8WVL7
ALRELMKLAPRYKLG

CACNA2D4

536

Q7Z3S7
KLGIYEAMKIGLVRP

DSP

2271

P15924
LMRLNQLKPGLQYKL

ILF3

406

Q12906
KLKPELMGLIRQQRL

ELMO3

526

Q96BJ8
EIRKLRQDILLMKPY

DEF8

366

Q6ZN54
MLLNKPLYLNIALLK

ENO4

251

A6NNW6
YAKVKLIRLVGIMLL

INPP5B

416

P32019
KNYGKILLPDTNLML

SACS

2446

Q9NZJ4
KLNYLDIGEIKKRPM

DCDC2

96

Q9UHG0
MLKKFERLNIPNLGI

DNAH5

571

Q8TE73
PLRYPVLMNRKKCLL

OR2T11

126

Q8NH01
YMEPILKALILKLKD

MTOR

771

P42345
KMLFPLLEELGRKYQ

PDILT

421

Q8N807
KLEPRGLIYVKVTLM

SYDE2

781

Q5VT97
LPAFNVLKLIGLMYL

TMC3

581

Q7Z5M5
SAVPYKRLMLLQIKG

SVIL

1436

O95425
LGYRLPLNDKEIKRM

SYNE1

7416

Q8NF91
LEIKALRMKLGPLQF

TMEM225B

131

P0DP42
ELVSYPKLKLKIMIR

SAMD5

121

Q5TGI4
LKPIQRMGKYALLLQ

PLEKHG4

861

Q58EX7
KNMDKIRLPSLYDLI

SLC35B3

371

Q9H1N7
MLLRYLLEPKAGKEK

PEX11A

26

O75192
FGLMKNLIRRLQKYP

NPRL2

316

Q8WTW4
YKRVMPDGKIQKLII

FARSB

96

Q9NSD9
LYDKGLLLTKMPLAL

RIOX1

626

Q9H6W3
NILIILRNMGYLKPR

MC2R

81

Q01718
RQLEMILNKPGLKYK

AKR1C1

171

Q04828
RLLEMILNKPGLKYK

AKR1C2

171

P52895
LDLLSKMLIYDPAKR

CDK1

261

P06493
RKYSVDLLMDLLKNP

CIP2A

251

Q8TCG1
MLLRLKSVLYLPGDF

CNGB3

536

Q9NQW8
MLKLLALRQLPDIYP

C15orf39

896

Q6ZRI6
KPMQILYKGTLRVLL

CNOT1

2086

A5YKK6
YKPKRLGNDIALMKL

TMPRSS3

296

P57727
GFDILLMKNLKPILL

TTLL11

516

Q8NHH1
KLGPALKIYARISML

PHC2

841

Q8IXK0
KQLLYLEKYRPKMRL

PTP4A2

141

Q12974
LLPLLTMAYLKGDLR

SPPL3

351

Q8TCT6
KPKLNTLKLYRLLPM

ZBTB4

406

Q9P1Z0
KLMRPLNALDELYRL

PREX2

1471

Q70Z35
LPYMIRSKLKLLLQG

PRKDC

3041

P78527
MSRPLLGLILLNEKY

XPO7

1001

Q9UIA9
VPMQRVLKYHLLLKE

VAV2

331

P52735
YISRGELLLKMNKPL

TMTC3

566

Q6ZXV5
LPQLKELYISRNKLM

TLR2

476

O60603
LLIKPVQRIMKYQLL

TRIO

2096

O75962
LKRLMAEYKQLTLNP

UBE2G2

6

P60604
LKSFGQMLLKYILRP

ZW10

241

O43264
KAYSLGDLPMKLQRI

KCNJ3

426

P48549
LKEYKQSRGLMPIKI

AK7

356

Q96M32
IIDYFRKMPLLLIDG

LCP2

501

Q13094
RMPLLLNPKLLSLEY

MUSK

556

O15146
SYVRALPLLKKMGIN

TMEM35A

46

Q53FP2