Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF600 ZNF713 ZNF665 ZNF652 ZNF790 ZNF347 NR5A2 HDX ZNF534 ZNF431 RORA ZNF701 ZNF679 PRDM2

1.74e-0414126614GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF600 ZNF713 ZNF665 ZNF652 ZNF790 ZNF347 NR5A2 HDX ZNF534 ZNF431 RORA ZNF701 ZNF679

1.85e-0412446613GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF600 ZNF713 ZNF665 ZNF652 ZNF790 ZNF347 NR5A2 HDX ZNF534 ZNF431 RORA ZNF701 ZNF679

2.28e-0412716613GO:0000987
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF600 ZNF713 ZNF665 ZNF652 ZNF790 ZNF347 NR5A2 HDX ZNF534 ZNF431 RORA ZNF701 ZNF679 PRDM2

2.45e-0414596614GO:0000977
GeneOntologyMolecularFunctionstructural constituent of skin epidermis

KRT81 KRT83 KRT86

3.87e-0443663GO:0030280
GeneOntologyMolecularFunctionproteoglycan binding

THBS1 PTPRC LRP1

6.41e-0451663GO:0043394
GeneOntologyBiologicalProcesstransforming growth factor beta receptor signaling pathway

THBS1 FBN2 ZFYVE9 LRP1 LTBP1 ADAM17 PML

2.55e-05276657GO:0007179
GeneOntologyBiologicalProcessregulation of transforming growth factor beta receptor signaling pathway

THBS1 FBN2 ZFYVE9 LRP1 LTBP1 ADAM17

3.15e-05192656GO:0017015
GeneOntologyBiologicalProcessregulation of cellular response to transforming growth factor beta stimulus

THBS1 FBN2 ZFYVE9 LRP1 LTBP1 ADAM17

3.44e-05195656GO:1903844
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN2 LTBP1

5.84e-054652GO:0035583
GeneOntologyBiologicalProcessnegative regulation of cellular component organization

LMOD3 THBS1 EFEMP1 CENPF TRPC5 MID1 LRP1 ADAM17 BECN1 TMEFF2 PML

7.38e-058646511GO:0051129
GeneOntologyBiologicalProcesscellular response to transforming growth factor beta stimulus

THBS1 FBN2 ZFYVE9 LRP1 LTBP1 ADAM17 PML

8.85e-05336657GO:0071560
GeneOntologyBiologicalProcessintermediate filament organization

KRT39 KRT81 KRT83 KRT86

9.23e-0575654GO:0045109
GeneOntologyBiologicalProcessresponse to transforming growth factor beta

THBS1 FBN2 ZFYVE9 LRP1 LTBP1 ADAM17 PML

1.01e-04343657GO:0071559
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

THBS1 FBN2 ZFYVE9 LRP1 LTBP1 ADAM17 BECN1 PML

1.32e-04482658GO:0007178
HumanPhenoAbnormal perifollicular morphology

KRT81 KRT83 KRT86 LRP1

7.95e-096264HP:0031285
HumanPhenoPerifollicular hyperkeratosis

KRT81 KRT83 KRT86

4.71e-074263HP:0007468
HumanPhenoAbnormality of hair growth rate

KRT81 KRT83 KRT86 ADAM17

1.16e-0529264HP:0011363
HumanPhenoSlow-growing hair

KRT81 KRT83 KRT86 ADAM17

1.16e-0529264HP:0002217
HumanPhenoFollicular hyperkeratosis

KRT81 KRT83 KRT86 LRP1

1.34e-0530264HP:0007502
HumanPhenoAbnormality of hair growth

KRT81 KRT83 KRT86 ADAM17

1.34e-0530264HP:0040170
HumanPhenoKeratosis pilaris

KRT81 KRT83 KRT86 LRP1

3.14e-0537264HP:0032152
HumanPhenoAbnormal duodenum morphology

XYLT2 FBN2 CENPF ADAM17 PALB2

6.78e-0588265HP:0002246
HumanPhenoChoroidal neovascularization

XYLT2 FBN2 EFEMP1

1.95e-0423263HP:0011506
MousePhenoabnormal bone mineral content

KDM3A LMOD3 THBS1 FBN2 THSD7A ZNF665 ZNF347 SCAF11 BICRAL LTBP1 ADAM17 TG

1.09e-057135312MP:0010122
DomainEGF-like_CS

THBS1 FBN2 EFEMP1 ATRNL1 LRP1 LTBP1 ADAM17 C8A LRP1B TMEFF2

1.59e-082616310IPR013032
DomaincEGF

FBN2 EFEMP1 LRP1 LTBP1 LRP1B

2.31e-0826635IPR026823
DomaincEGF

FBN2 EFEMP1 LRP1 LTBP1 LRP1B

2.31e-0826635PF12662
DomainEGF_3

THBS1 FBN2 EFEMP1 ATRNL1 LRP1 LTBP1 C8A LRP1B TMEFF2

8.89e-08235639PS50026
DomainEGF-like_dom

THBS1 FBN2 EFEMP1 ATRNL1 LRP1 LTBP1 C8A LRP1B TMEFF2

1.46e-07249639IPR000742
DomainEGF_1

THBS1 FBN2 EFEMP1 ATRNL1 LRP1 LTBP1 C8A LRP1B TMEFF2

1.78e-07255639PS00022
DomainEGF_2

THBS1 FBN2 EFEMP1 ATRNL1 LRP1 LTBP1 C8A LRP1B TMEFF2

2.47e-07265639PS01186
DomainEGF_CA

THBS1 FBN2 EFEMP1 LRP1 LTBP1 LRP1B

4.40e-0786636PF07645
DomainGrowth_fac_rcpt_

FBN2 EFEMP1 KRT83 LRP1 LTBP1 C8A LRP1B

9.26e-07156637IPR009030
DomainEGF

THBS1 FBN2 EFEMP1 ATRNL1 LRP1 LTBP1 LRP1B TMEFF2

1.19e-06235638SM00181
DomainEGF_CA

THBS1 FBN2 EFEMP1 LRP1 LTBP1 LRP1B

3.44e-06122636SM00179
DomainEGF-like_Ca-bd_dom

THBS1 FBN2 EFEMP1 LRP1 LTBP1 LRP1B

3.78e-06124636IPR001881
DomainDUF5050

LRP1 LRP1B

1.12e-052632IPR032485
DomainDUF5050

LRP1 LRP1B

1.12e-052632PF16472
DomainLY

LRP1 ROS1 LRP1B

1.62e-0515633SM00135
DomainLDLR_classB_rpt

LRP1 ROS1 LRP1B

1.62e-0515633IPR000033
Domainzf-C2H2

ZNF600 ZNF713 ZNF665 ZNF652 ZNF790 ZNF347 ZNF534 ZNF431 ZNF701 ZNF679 PRDM2

1.80e-056936311PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF600 ZNF713 ZNF665 ZNF652 ZNF790 ZNF347 ZNF534 ZNF431 ZNF701 ZNF679 PRDM2

1.82e-056946311IPR013087
DomainEGF_Ca-bd_CS

FBN2 EFEMP1 LRP1 LTBP1 LRP1B

1.89e-0597635IPR018097
DomainEGF_CA

FBN2 EFEMP1 LRP1 LTBP1 LRP1B

2.08e-0599635PS01187
DomainASX_HYDROXYL

FBN2 EFEMP1 LRP1 LTBP1 LRP1B

2.19e-05100635PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

FBN2 EFEMP1 LRP1 LTBP1 LRP1B

2.90e-05106635IPR000152
DomainZINC_FINGER_C2H2_2

ZNF600 ZNF713 ZNF665 ZNF652 ZNF790 ZNF347 ZNF534 ZNF431 ZNF701 ZNF679 PRDM2

5.01e-057756311PS50157
DomainZINC_FINGER_C2H2_1

ZNF600 ZNF713 ZNF665 ZNF652 ZNF790 ZNF347 ZNF534 ZNF431 ZNF701 ZNF679 PRDM2

5.13e-057776311PS00028
DomainIntermediate_filament_CS

KRT39 KRT81 KRT83 KRT86

6.03e-0563634IPR018039
DomainZnf_C2H2-like

ZNF600 ZNF713 ZNF665 ZNF652 ZNF790 ZNF347 ZNF534 ZNF431 ZNF701 ZNF679 PRDM2

6.37e-057966311IPR015880
DomainKeratin_2_head

KRT81 KRT83 KRT86

7.04e-0524633IPR032444
DomainKeratin_2_head

KRT81 KRT83 KRT86

7.04e-0524633PF16208
DomainZnf_C2H2

ZNF600 ZNF713 ZNF665 ZNF652 ZNF790 ZNF347 ZNF534 ZNF431 ZNF701 ZNF679 PRDM2

7.05e-058056311IPR007087
DomainZnF_C2H2

ZNF600 ZNF713 ZNF665 ZNF652 ZNF790 ZNF347 ZNF534 ZNF431 ZNF701 ZNF679 PRDM2

7.29e-058086311SM00355
Domain-

ZNF600 ZNF665 ZNF652 ZNF790 ZNF347 ZNF534 ZNF431 ZNF701 ZNF679 PRDM2

8.45e-0567963103.30.160.60
DomainKeratin_II

KRT81 KRT83 KRT86

9.00e-0526633IPR003054
DomainFilament

KRT39 KRT81 KRT83 KRT86

9.64e-0571634SM01391
DomainIF

KRT39 KRT81 KRT83 KRT86

1.02e-0472634PS00226
DomainFilament

KRT39 KRT81 KRT83 KRT86

1.07e-0473634PF00038
DomainIF

KRT39 KRT81 KRT83 KRT86

1.26e-0476634IPR001664
DomainKRAB

ZNF713 ZNF790 ZNF347 ZNF534 ZNF431 ZNF701 ZNF679

1.97e-04358637PS50805
DomainKRAB

ZNF713 ZNF790 ZNF347 ZNF534 ZNF431 ZNF701 ZNF679

1.97e-04358637PF01352
DomainTB

FBN2 LTBP1

2.33e-047632PF00683
DomainKRAB

ZNF713 ZNF790 ZNF347 ZNF534 ZNF431 ZNF701 ZNF679

2.37e-04369637SM00349
DomainKRAB

ZNF713 ZNF790 ZNF347 ZNF534 ZNF431 ZNF701 ZNF679

2.41e-04370637IPR001909
Domain-

LRP1 ROS1 LRP1B

3.07e-04396332.120.10.30
Domain-

FBN2 LTBP1

3.09e-0486323.90.290.10
DomainLDLR_class-A_CS

LRP1 C8A LRP1B

3.31e-0440633IPR023415
DomainTB

FBN2 LTBP1

3.97e-049632PS51364
DomainTB_dom

FBN2 LTBP1

3.97e-049632IPR017878
DomainLdl_recept_a

LRP1 C8A LRP1B

4.69e-0445633PF00057
Domain-

LRP1 C8A LRP1B

5.01e-04466334.10.400.10
Domain6-blade_b-propeller_TolB-like

LRP1 ROS1 LRP1B

5.01e-0446633IPR011042
DomainLDLRA_1

LRP1 C8A LRP1B

5.68e-0448633PS01209
DomainLDLRA_2

LRP1 C8A LRP1B

6.03e-0449633PS50068
DomainLDrepeatLR_classA_rpt

LRP1 C8A LRP1B

6.03e-0449633IPR002172
DomainLDLa

LRP1 C8A LRP1B

6.03e-0449633SM00192
Domainzf-C2H2_6

ZNF600 ZNF652 ZNF790 ZNF431 ZNF701 PRDM2

6.54e-04314636PF13912
DomainEGF

LRP1 LTBP1 LRP1B TMEFF2

8.65e-04126634PF00008
DomainLdl_recept_b

LRP1 LRP1B

9.93e-0414632PF00058
DomainLDLRB

LRP1 LRP1B

9.93e-0414632PS51120
DomainTSP_1

THBS1 THSD7A C8A

1.26e-0363633PF00090
DomainTSP1

THBS1 THSD7A C8A

1.38e-0365633SM00209
DomainTSP1_rpt

THBS1 THSD7A C8A

1.38e-0365633IPR000884
DomainTSP1

THBS1 THSD7A C8A

1.38e-0365633PS50092
DomainZnf_FYVE_PHD

KDM3A ZFYVE9 PHF3 BSN

1.53e-03147634IPR011011
Domain-

ZFYVE9 PHF3 MID1 SCAF11 BSN PML

3.99e-034496363.30.40.10
DomainZnf_RING/FYVE/PHD

ZFYVE9 PHF3 MID1 SCAF11 BSN PML

4.44e-03459636IPR013083
Pubmed

Structure and site of expression of a murine type II hair keratin.

KRT81 KRT83 KRT86

6.83e-0936731372089
Pubmed

Transient expression of mouse hair keratins in transfected HeLa cells: interactions between "hard" and "soft" keratins.

KRT81 KRT83 KRT86

6.83e-0936731712823
Pubmed

Novel KRT83 and KRT86 mutations associated with monilethrix.

KRT81 KRT83 KRT86

6.83e-09367325557232
Pubmed

Comprehensive analysis of keratin gene clusters in humans and rodents.

KRT39 KRT81 KRT83 KRT86

2.25e-081667415085952
Pubmed

Keratins of the human hair follicle.

KRT81 KRT83 KRT86

2.73e-08467315797458
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

THBS1 FBN2 THSD7A ATRNL1 LRP1

2.69e-077167533541421
Pubmed

Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain.

KRT81 KRT83 KRT86

1.48e-061267310692104
Pubmed

Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages.

LRP1 ADAM17

3.66e-06267220610799
Pubmed

Striking differences of LDL receptor-related protein 1B expression in mouse and human.

LRP1 LRP1B

3.66e-06267215963947
Pubmed

Ceramide kinase regulates the production of tumor necrosis factor α (TNFα) via inhibition of TNFα-converting enzyme.

CERK ADAM17

3.66e-06267222009748
Pubmed

A missense mutation in the type II hair keratin hHb3 is associated with monilethrix.

KRT83 KRT86

3.66e-06267215744029
Pubmed

Internalization but not binding of thrombospondin-1 to low density lipoprotein receptor-related protein-1 requires heparan sulfate proteoglycans.

THBS1 LRP1

3.66e-06267214991768
Pubmed

Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17.

ADAM17 TMEFF2

3.66e-06267217942404
Pubmed

Antigen-induced regulation of T-cell motility, interaction with antigen-presenting cells and activation through endogenous thrombospondin-1 and its receptors.

THBS1 LRP1

3.66e-06267225393517
Pubmed

HPP1 Ectodomain Shedding is Mediated by ADAM17 and is Necessary for Tumor Suppression in Colon Cancer.

ADAM17 TMEFF2

3.66e-06267232450419
Pubmed

A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1.

KRT81 KRT86

3.66e-0626729665406
Pubmed

Cellular internalization and degradation of thrombospondin-1 is mediated by the amino-terminal heparin binding domain (HBD). High affinity interaction of dimeric HBD with the low density lipoprotein receptor-related protein.

THBS1 LRP1

3.66e-0626729045712
Pubmed

Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1).

THBS1 LRP1

3.66e-06267217154366
Pubmed

A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix.

KRT81 KRT86

3.66e-0626729402962
Pubmed

Regulation of T-lymphocyte motility, adhesion and de-adhesion by a cell surface mechanism directed by low density lipoprotein receptor-related protein 1 and endogenous thrombospondin-1.

THBS1 LRP1

3.66e-06267224877199
Pubmed

PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.

KRT81 KRT83 KRT86

6.48e-061967321285247
Pubmed

New consensus nomenclature for mammalian keratins.

KRT39 KRT81 KRT83 KRT86

6.88e-066367416831889
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TET2 KDM3A CERK FBXL7 VPS13C SLMAP SCAF11 BSN

8.07e-0652967814621295
Pubmed

HTRA1, an age-related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1.

THBS1 EFEMP1

1.10e-05367229730901
Pubmed

Sequence data and chromosomal localization of human type I and type II hair keratin genes.

KRT81 KRT86

1.10e-0536727556444
Pubmed

Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis.

THBS1 LRP1

1.10e-05367218653767
Pubmed

Sequences and differential expression of three novel human type-II hair keratins.

KRT83 KRT86

1.10e-0536729084137
Pubmed

Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer.

BECN1 PALB2

1.10e-05367223650262
Pubmed

Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17.

LYPD3 ADAM17

1.10e-05367218979631
Pubmed

Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis.

THBS1 BECN1

1.10e-05367228174297
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TET2 CENPF LRP1 AKAP1 MBIP PALB2 PRDM2

1.61e-0541867734709266
Pubmed

Interaction between the C8 alpha-gamma and C8 beta subunits of human complement C8: role of the C8 beta N-terminal thrombospondin type 1 module and membrane attack complex/perforin domain.

THBS1 C8A

2.19e-05467212220191
Pubmed

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

FBN2 LTBP1

2.19e-05467212429738
Pubmed

A Disintegrin and Metalloproteinase 17 is required for ILC2 responses to IL-33.

RORA ADAM17

2.19e-05467230926166
Pubmed

Human eye development is characterized by coordinated expression of fibrillin isoforms.

FBN2 EFEMP1

2.19e-05467225406291
Pubmed

Functions for Retinoic Acid-Related Orphan Receptor Alpha (RORα) in the Activation of Macrophages During Lipopolysaccharide-Induced Septic Shock.

PTPRC RORA

2.19e-05467233767712
Pubmed

Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle.

KRT81 KRT86

2.19e-0546729457912
Pubmed

Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.

THBS1 LRP1

2.19e-0546727775583
Pubmed

Retinoic Acid-Related Orphan Receptor α Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation.

PTPRC RORA

3.64e-05567237387671
Pubmed

Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress.

BECN1 NOD2

3.64e-05567236738733
Pubmed

POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.

FBN2 LTBP1

3.64e-05567234411563
Pubmed

Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells.

PTPRC BECN1

3.64e-05567238754428
Pubmed

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

TET2 EFEMP1 ZNF652 LTBP1 PML

4.12e-0519867520881960
Pubmed

Methylation of CLDN6, FBN2, RBP1, RBP4, TFPI2, and TMEFF2 in esophageal squamous cell carcinoma.

FBN2 TMEFF2

5.46e-05667219288010
Pubmed

High-throughput mammalian two-hybrid screening for protein-protein interactions using transfected cell arrays.

THBS1 FBN2

5.46e-05667218254948
Pubmed

An extended consensus motif enhances the specificity of substrate modification by SUMO.

NR5A2 PML

5.46e-05667217036045
Pubmed

Variants at the 3p21 locus influence susceptibility and phenotype both in adults and early-onset patients with inflammatory bowel disease.

BSN NOD2

5.46e-05667220024904
Pubmed

Cytoplasmic PML function in TGF-beta signalling.

ZFYVE9 PML

5.46e-05667215356634
Pubmed

TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence.

RORA PML

5.46e-05667228486108
Pubmed

Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression.

THBS1 LTBP1

7.63e-05767219998449
Pubmed

Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling.

ZFYVE9 PML

7.63e-05767216916642
Pubmed

Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signalling.

ZFYVE9 PML

1.02e-04867218511908
Pubmed

Mapping Extracellular Protein-Protein Interactions Using Extracellular Proximity Labeling (ePL).

THBS1 FBN2 EFEMP1 KRT81 LTBP1

1.17e-0424767539238192
Pubmed

Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection.

BECN1 NOD2

1.30e-04967236221902
Pubmed

Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.

FBN2 LTBP1

1.30e-04967238844137
Pubmed

TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.

MID1 NOD2

1.30e-04967222829933
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF665 ZNF790 ZNF347 NR5A2 ZDHHC14 RORA ZNF679 PML

1.60e-0480867820412781
Pubmed

Maturation of the HIV reverse transcription complex: putting the jigsaw together.

AKAP1 PML

1.63e-041067219750561
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

TET2 KDM3A THBS1 EFEMP1 ATRNL1 KRT83 LRP1 SESN3 BECN1 LRP1B

1.67e-041285671035914814
Pubmed

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

BSN PALB2 NOD2

1.95e-045867317554300
Pubmed

Genomic organization, nucleotide sequence, biophysical properties, and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4 to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13.

THBS1 KCNA1

1.99e-04116728020965
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP1 LRP1B

1.99e-041167224639464
Pubmed

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

KRT81 KRT83 KRT86 LTBP1 PRDM2

2.24e-0428467529459677
Pubmed

Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.

PTPRC TG

2.81e-041367222724066
Pubmed

IRGM governs the core autophagy machinery to conduct antimicrobial defense.

BECN1 NOD2

2.81e-041367225891078
Pubmed

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

LRP1 LRP1B

3.28e-041467215082773
Pubmed

DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis.

KRT81 KRT83 KRT86

3.41e-047067334255829
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

THBS1 FBN2 EFEMP1 LTBP1

3.71e-0417567428071719
Pubmed

Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.

NR5A2 RORA

3.78e-041567214701856
Pubmed

TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression.

TET2 KDM3A

3.78e-041567231530896
Pubmed

Hague (Hag). A new mouse hair mutation with an unstable semidominant allele.

KRT81 KRT86

4.31e-041667212399393
Pubmed

Esophageal Atresia / Tracheoesophageal Fistula Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

MID1 PALB2

4.31e-041667220301753
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

XYLT2 THBS1 FBN2 EFEMP1 LRP1 LTBP1 ADAM17 AKAP1 LRP1B

4.79e-04120167935696571
Pubmed

A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.

FBN2 TG

4.88e-041767222832960
Pubmed

The expression pattern of nuclear receptors during cerebellar development.

NR5A2 RORA

4.88e-041767217205580
Pubmed

Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7.

PTPRC ADAM17

4.88e-041767217804806
Pubmed

Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis.

KRT81 KRT86

6.12e-041967227234308
Pubmed

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

THBS1 FBN2 LTBP1

6.24e-048667328327460
Pubmed

Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.

EFEMP1 BSN

6.79e-042067220846217
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

PHF3 MID1 BSN PRDM2

7.10e-0420867433230847
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

KDM3A PTPRC PHF3 SCAF11 AKAP1 PALB2 PRDM2

7.19e-0477467715302935
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

LRP1 LRP1B

7.50e-042167221337463
Pubmed

Hippo signaling regulates differentiation and maintenance in the exocrine pancreas.

PTPRC NR5A2

8.24e-042267223454691
Pubmed

A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.

NR5A2 RORA

8.24e-042267223975195
Pubmed

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.

KRT81 KRT83 KRT86

8.59e-049667323580065
Pubmed

Functional proteomics mapping of a human signaling pathway.

FBN2 PTPRC ZFYVE9 THSD7A KRT81 LRP1

9.74e-0459167615231748
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

LRP1 GABRQ LRP1B

9.95e-0410167323382219
Pubmed

Proteomics characterization of extracellular space components in the human aorta.

THBS1 EFEMP1 LTBP1

9.95e-0410167320551380
Pubmed

ERp57 is essential for efficient folding of glycoproteins sharing common structural domains.

EFEMP1 ADAM17

1.07e-032567217170699
Pubmed

Identification of 15 loci influencing height in a Korean population.

EFEMP1 LTBP1

1.24e-032767219893584
Pubmed

Identification of differentially expressed genes in mouse spermatogenesis.

ZNF665 ZNF347

1.24e-032767214581517
Pubmed

Genetic risk profiling and prediction of disease course in Crohn's disease patients.

BSN NOD2

1.34e-032867219422935
Pubmed

Alternatively spliced isoforms of WT1 control podocyte-specific gene expression.

SGIP1 THSD7A

1.34e-032867225993318
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

THBS1 EFEMP1 LTBP1 ADAM17

1.36e-0324867424006456
Pubmed

ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1.

FBN2 ANKRD26 BSN

1.38e-0311367334474245
Pubmed

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

TET2 LRP1

1.54e-033067221946350
Pubmed

ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.

FBN2 LTBP1

1.54e-033067232882513
Pubmed

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.

EFEMP1 LRP1 LTBP1

1.56e-0311867321078624
Pubmed

Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.

FBN2 LTBP1

1.64e-033167225762570
Pubmed

Molecular and spatial landmarks of early mouse skin development.

THBS1 PTPRC

1.86e-033367237591247
InteractionZFP41 interactions

FBN2 LRP1 LTBP1 AKAP1 LRP1B

1.19e-0657665int:ZFP41
InteractionZDHHC15 interactions

THBS1 FBN2 THSD7A ATRNL1 LRP1 TMEFF2

3.38e-06125666int:ZDHHC15
Cytoband12q13

KRT81 KRT83 KRT86

1.58e-047167312q13
Cytoband19q13.41

ZNF600 ZNF534 ZNF701

2.09e-047867319q13.41
Cytoband15q22.2

VPS13C RORA

8.30e-042967215q22.2
CytobandEnsembl 112 genes in cytogenetic band chr3p14

LMOD3 CCDC66 SLMAP

1.15e-03140673chr3p14
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF600 ZNF665 ZNF790 ZNF347 LYPD3 ZNF534 ZNF701

1.75e-031192677chr19q13
CytobandEnsembl 112 genes in cytogenetic band chr12q13

KRT81 KRT83 KRT86 LRP1

3.45e-03423674chr12q13
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF600 ZNF713 ZNF665 ZNF652 ZNF790 ZNF347 ZNF534 ZNF431 ZNF701 ZNF679

1.85e-05718491028
GeneFamilyKeratins, type II

KRT81 KRT83 KRT86

5.23e-0527493609
GeneFamilyLow density lipoprotein receptors

LRP1 LRP1B

5.51e-0413492634
CoexpressionAtlasdev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#4_top-relative-expression-ranked_500

FBN2 EFEMP1 ATRNL1 LRP1 LTBP1 TMEFF2

4.08e-05207656gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k4_500
CoexpressionAtlasdev gonad_e11.5_F_GonadVasMes_Flk_top-relative-expression-ranked_500

KDM3A FBN2 EFEMP1 ATRNL1 LRP1 SESN3 LTBP1 TMEFF2

4.34e-05423658gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_500
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D122|Adult / Lineage, Cell type, age group and donor

FBXL7 SGIP1 THSD7A NR5A2 ZDHHC14 TM4SF18

2.43e-07173676dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCellmetastatic_Lymph_Node-Endothelial_cells-Lymphatic_ECs|metastatic_Lymph_Node / Location, Cell class and cell subclass

THBS1 EFEMP1 FBXL7 SGIP1 MID1 TM4SF18

2.52e-07174676d551bc29afef071adf4c9bb80345352ec33441d8
ToppCellCOVID-19-Neuronal_cells-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

FBXL7 SGIP1 THSD7A NR5A2 ZDHHC14 TM4SF18

3.61e-071856764a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCellCOVID-19-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

FBXL7 SGIP1 THSD7A NR5A2 ZDHHC14 TM4SF18

3.61e-0718567636ce23893915f5c380cca39b2c33a516edf31c3a
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

FBXL7 SGIP1 THSD7A NR5A2 ZDHHC14 TM4SF18

3.97e-071886762db80767903703e7e0a1a37c598f7877a909ee94
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 FBXL7 SGIP1 ATRNL1 LRP1 LTBP1

4.92e-0719567649c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 FBXL7 SGIP1 ATRNL1 LRP1 LTBP1

4.92e-07195676dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 SGIP1 VPS13C LRP1 RORA SCAF11

4.92e-071956765c86fddd6d0530beecf45ea5ba6b823123847696
ToppCellBronchial-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBXL7 SGIP1 THSD7A NR5A2 ZDHHC14 TM4SF18

5.37e-07198676b3a020522e064bb61949d38e442f24026e339364
ToppCellBronchial-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBXL7 SGIP1 THSD7A NR5A2 ZDHHC14 TM4SF18

5.37e-07198676fc4b7c3ad52bc5c8b40fa04a156bfbb58afa2872
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TET2 PTPRC PHF3 VPS13C SCAF11 PRDM2

5.70e-0720067612f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF713 CCDC66 ANKRD26 SESN3 TG

4.19e-06159675b9d34b9ed8db798f5ea93c44b469cae499403cb8
ToppCellControl-Neuronal_cells-Neuronal_cells|Control / group, cell type (main and fine annotations)

FBXL7 SGIP1 THSD7A NR5A2 ZDHHC14

6.87e-0617667598c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCellControl-Neuronal_cells|Control / group, cell type (main and fine annotations)

FBXL7 SGIP1 THSD7A NR5A2 ZDHHC14

6.87e-06176675c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LMOD3 THBS1 SGIP1 ATRNL1 LTBP1

7.06e-06177675b872ee91e01265b101b81bd304cf6b95d5419e68
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D231|Adult / Lineage, Cell type, age group and donor

FBXL7 THSD7A NR5A2 ZDHHC14 TM4SF18

7.25e-06178675c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCell367C-Lymphocytic-NK_cells-NK_cell_A|367C / Donor, Lineage, Cell class and subclass (all cells)

ZNF600 PTPRC KRT81 KRT86 RORA

7.66e-06180675023c83f0c9d0280983c6fd28ecf04bfa6b1b89e2
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 PTPRC PHF3 VPS13C SCAF11

8.52e-061846751154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel|Children_(3_yrs) / Lineage, Cell type, age group and donor

FBXL7 SGIP1 NR5A2 ZDHHC14 TM4SF18

9.45e-06188675c2805232618a7b6f844d34e37ad458a9923dbfe1
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FBXL7 SGIP1 NR5A2 ZDHHC14 TM4SF18

9.45e-06188675aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCell10x3'2.3-week_12-13-Lymphocytic_NK|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

PTPRC KRT81 KRT83 KRT86 RORA

9.70e-06189675723c57f278919e8251d56b3d19411f9088319450
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBXL7 SGIP1 ATRNL1 LRP1 LTBP1

9.70e-06189675c734e5693808a0333139e87bd5be2597a9252afe
ToppCell10x3'2.3-week_12-13-Lymphocytic_NK-T_NK|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

PTPRC KRT81 KRT83 KRT86 RORA

9.70e-06189675960374f5fb278659500a7c948c3068a95dd62eb0
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.5.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PTPRC KRT81 KRT83 KRT86 NR5A2

9.95e-06190675ce049630ed69d31f00acbc1b5b0896efc592121f
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBXL7 SGIP1 ATRNL1 LRP1 LTBP1

9.95e-061906752e592323085ba9c019d678ac2a784462ab470ed9
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PTPRC KRT81 KRT83 KRT86 RORA

9.95e-06190675af39d2a46d9502cec69a69b7e8ffef78fc8311c3
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel|Adult / Lineage, Cell type, age group and donor

FBXL7 THSD7A NR5A2 ZDHHC14 TM4SF18

9.95e-0619067591bf3b7e9148589757436a53a4f58e0ebfe54400
ToppCellfacs-GAT-Fat-24m-Mesenchymal|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 THSD7A LRP1 LTBP1 TMEFF2

9.95e-061906753720e64129f3f3268b1dc14031a76f41c38241c2
ToppCellfacs-GAT-Fat-24m-Mesenchymal-mesenchymal_progenitor|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 THSD7A LRP1 LTBP1 TMEFF2

9.95e-0619067573a50426f972f08f9bb525ad5c0b774187ab5d6a
ToppCellfacs-GAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 THSD7A LRP1 LTBP1 TMEFF2

9.95e-06190675b55cf1fb586b724295b7b038483249847bb344fc
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

THBS1 FBXL7 SGIP1 RORA LTBP1

9.95e-061906753a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBXL7 SGIP1 ATRNL1 LRP1 LTBP1

9.95e-06190675445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCellIPF-Endothelial-Lymphatic|World / Disease state, Lineage and Cell class

EFEMP1 FBXL7 SGIP1 ZDHHC14 TM4SF18

9.95e-06190675ac029e73da5995221c9b9af551d85e4b835e21d6
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBXL7 SGIP1 ATRNL1 LRP1 LTBP1

1.02e-05191675c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 SGIP1 ATRNL1 LRP1 LTBP1

1.02e-051916751caf726bd07fdca389e678fc16304a6ef1790423
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 THSD7A VPS13C RORA LTBP1

1.02e-051916757d1595e616f6f111fc2f5bc1b179c5d67d624cc9
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBXL7 SGIP1 ATRNL1 LRP1 LTBP1

1.02e-05191675806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBXL7 SGIP1 ATRNL1 LRP1 LTBP1

1.02e-05191675cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 EFEMP1 MID1 LRP1 TMEFF2

1.02e-051916751b26056df078674f37a6c06f6256b30cfcec21a7
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 SGIP1 ATRNL1 LRP1 LTBP1

1.02e-051916753d60c46bced2984c27a1fcf2910bc38b31fb0148
ToppCellIPF-Endothelial-Lymphatic|IPF / Disease state, Lineage and Cell class

EFEMP1 FBXL7 SGIP1 ZDHHC14 TM4SF18

1.05e-051926752496edd8f3a41146d418879de9ee2ccc7857431f
ToppCellCOPD-Endothelial-Lymphatic|World / Disease state, Lineage and Cell class

EFEMP1 FBXL7 SGIP1 ZDHHC14 TM4SF18

1.07e-0519367525bdc557055b5bce6a21f8696b48e991c696b979
ToppCellControl-Endothelial-Lymphatic|Control / Disease state, Lineage and Cell class

EFEMP1 FBXL7 NR5A2 ZDHHC14 TM4SF18

1.07e-0519367564d19be73e5432d491436a01da5de5c926b615a9
ToppCellControl-Endothelial-Endothelial-Gen_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBXL7 THSD7A NR5A2 ZDHHC14 LTBP1

1.07e-05193675e1d546165dcc2392f540162206852c4717d7306f
ToppCellControl-Fibroblasts-Intermediate_pathological_FB|Control / group, cell type (main and fine annotations)

THBS1 FBXL7 SGIP1 RORA LTBP1

1.10e-0519467503a269f75a481ea54aea8e6444605db8d6df493d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 FBXL7 ATRNL1 LRP1 LTBP1

1.10e-05194675240d122dcb9dd1ab2867503ad85869853adcacae
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 FBXL7 ATRNL1 LRP1 LTBP1

1.10e-05194675ae7df037592f1c20c9d32be15fe6fc3c562ebeb1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 FBXL7 ATRNL1 LRP1 LTBP1

1.13e-05195675d8ebb94f30d4a655d6b29dd6a3076be2403d2356
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBXL7 SGIP1 ATRNL1 LRP1 LTBP1

1.13e-05195675edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EFEMP1 FBXL7 ATRNL1 LRP1 LTBP1

1.13e-051956753c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 FBXL7 ATRNL1 LRP1 LTBP1

1.13e-0519567544d7bef5f59c2c2bad1392ee6aabdaa5d7f531d9
ToppCellChildren_(3_yrs)-Endothelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

FBXL7 ST8SIA6 NR5A2 ZDHHC14 TM4SF18

1.13e-05195675094cf6591daa5ffad36e44122b6f524a3a34c2fd
ToppCelldistal-Hematologic-Natural_Killer_T-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PTPRC KRT81 KRT83 KRT86 NR5A2

1.16e-0519667505d2a15ba702b07ef59c55891a06da02cdd15f7f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 FBXL7 ATRNL1 LRP1 LTBP1

1.16e-05196675ba869f7a86f37fd6d84d6ad69baca0e0faaf5887
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 FBXL7 ATRNL1 LRP1 LTBP1

1.16e-0519667530ad56d49000e4ddce73b4443b3994564bd1e2d6
ToppCellEndothelial|World / Lineage, Cell type, age group and donor

FBXL7 ST8SIA6 NR5A2 ZDHHC14 TM4SF18

1.16e-0519667596c6d78482a130ce4e29f6629972a06d10d7530e
ToppCelldistal-Hematologic-Natural_Killer_T|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PTPRC KRT81 KRT83 KRT86 NR5A2

1.19e-051976755cb1b45f5dc8fbd9e54db9c943450ce2cc7000e4
ToppCellCOVID-19-Fibroblasts-Intermediate_pathological_FB|COVID-19 / group, cell type (main and fine annotations)

THBS1 FBXL7 SGIP1 RORA LTBP1

1.19e-05197675f1c8936986123a3151140c374fcd62d6705c530b
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 EFEMP1 SGIP1 ATRNL1 LTBP1

1.19e-0519767585a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 EFEMP1 SGIP1 ATRNL1 LTBP1

1.19e-05197675e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCellnucseq-Endothelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FBXL7 ST8SIA6 NR5A2 ZDHHC14 TM4SF18

1.19e-05197675ebf9be068eaa658493fa7884fd19f34642922acb
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 FBXL7 SGIP1 ATRNL1 LTBP1

1.19e-051976759b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCellCOVID-19-Fibroblasts|COVID-19 / group, cell type (main and fine annotations)

THBS1 FBXL7 SGIP1 RORA LTBP1

1.19e-05197675fb847f2277609c31fffcdf49517243ce0684facf
ToppCellsystemic_lupus_erythematosus-flare|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PTPRC PHF3 VPS13C RORA SCAF11

1.21e-051986754c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 FBXL7 SGIP1 ATRNL1 LTBP1

1.21e-0519867579576525a10ed3e3a9d1608077cd16ecda23376f
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBXL7 SGIP1 NR5A2 ZDHHC14 TM4SF18

1.21e-051986759ab0db78394e730f6866b2db80047149024ad5f6
ToppCellIPF-Stromal|IPF / Disease state, Lineage and Cell class

EFEMP1 FBXL7 SGIP1 RORA LTBP1

1.21e-05198675ece914c32c9b123b779aa9624b92e6230763a20e
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBXL7 SGIP1 NR5A2 ZDHHC14 TM4SF18

1.21e-05198675e47d0e2c6353315c85d7007742bb16b0f05795ed
ToppCellILEUM-non-inflamed-(6)_ILC-(6)_ILC3|(6)_ILC / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CERK SGIP1 KRT81 KRT86 RORA

1.24e-05199675ba144739f65560207303c0143e8de1e86922bebb
ToppCellILEUM-inflamed-(6)_ILC-(6)_ILC3|(6)_ILC / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CERK SGIP1 KRT81 KRT86 RORA

1.24e-0519967502879df850b0c72b57d7b22cfc43f3407e182dcb
ToppCellParenchymal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

THBS1 FBXL7 SGIP1 LRP1 LTBP1

1.27e-05200675cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCellBronchial-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

THBS1 FBXL7 SGIP1 LRP1 LTBP1

1.27e-05200675cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

THBS1 FBXL7 SGIP1 LRP1 LTBP1

1.27e-05200675311fab076f2ceb258e3970eb21e39344b894042a
ToppCelldroplet-Tongue-nan-24m-Epithelial-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT39 KRT81 KRT83 KRT86

1.85e-05104674a4ae3cae44aac8b6e0d14896f9acab44f0cc97c4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THSD7A ST8SIA6 SHOC1 LRRC9

6.96e-05146674e887e9de895fd453faa703997ef372cc6410fc49
ToppCell367C-Lymphocytic-NK_cells-NK_cell_E|367C / Donor, Lineage, Cell class and subclass (all cells)

ZNF713 KRT81 KRT86 BICRAL

7.53e-05149674f18bddc84b064f3d57a1281d5172c404d87f25da
ToppCell343B-Lymphocytic-NK_cells-NK_cell_E|343B / Donor, Lineage, Cell class and subclass (all cells)

ZNF600 KRT81 KRT86 BICRAL

9.22e-051576740362c04b7b0b5017964b3a73ee678ae53e7238d7
ToppCellSevere-Lymphoid-NK-Proliferating_T|Severe / Condition, Lineage, Cell class and cell subclass

ZNF665 KRT81 KRT86 TG

9.92e-05160674cb2276d9bd78508644420e9580d3c17b914224cb
ToppCellControl-Treg|World / Disease group and Cell class

LMOD3 SGIP1 SHOC1 SESN3

1.02e-04161674ead9f5a491321f9e307f7c97e47a4ca124f59bb6
ToppCell10x5'-Lung-Lymphocytic_T_CD4/8-lo|Lung / Manually curated celltypes from each tissue

PTPRC KRT81 KRT86 NR5A2

1.02e-04161674a1f10e04836848b1deaf295fae033f54d1572fcd
ToppCellnormal-na-Lymphocytic_T-T4_reg-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

PTPRC THSD7A SESN3 RORA

1.07e-0416367443887e7687fc6367efac0c1f56a9534b06f47b7f
ToppCell10x5'-GI_small-bowel-Lymphocytic_NK-NK_CD56bright_CD16-|GI_small-bowel / Manually curated celltypes from each tissue

ST8SIA6 KRT81 KRT83 KRT86

1.09e-0416467436e64e4f717dd59b352c20ff9742ca1e232342bb
ToppCellEndothelial-B-HP_01|World / lung cells shred on cell class, cell subclass, sample id

SGIP1 THSD7A LYPD3 TM4SF18

1.12e-0416567410087d8bd2985906ef19547fe77eb178ae5e1638
ToppCell10x5'-Liver-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated|Liver / Manually curated celltypes from each tissue

CCDC66 ZFYVE9 ANKRD26 SESN3

1.14e-041666749afa33b5ad27dc33576be592f9b22d8161366838
ToppCellNS-critical-d_0-4-Epithelial-unknown_epithelial|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FBXL7 HDX SHOC1 BICRAL

1.14e-04166674dd02bbe4af609c6348dc92417254f4740f2900a8
ToppCellPND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EFEMP1 CENPF GABRQ TG

1.17e-04167674a90f905ef38437752e2b0b71bd0322a184de1861
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-ILC3|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SGIP1 KRT81 KRT86 RORA

1.20e-041686744f2f78e14f044b535847bcdbbcec8c0fc8529870
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 LRP1 GABRQ TMEFF2

1.22e-04169674bb43abad2c049b7f4d307737347290e01b3339a3
ToppCellfacs-Heart-LV-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 EFEMP1 THSD7A RORA

1.22e-04169674849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 LRP1 GABRQ TMEFF2

1.22e-041696745f18e3f40a5b1b167903f37516ec8181e889c7c5
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 LRP1 GABRQ TMEFF2

1.22e-041696748bfa2d3bb541d02f55d7c95b8fd156c8403befca
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-NK_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PTPRC ST8SIA6 KRT81 KRT86

1.28e-04171674f16cb64b8844c2668922c786888efaa9f873afcc
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 SGIP1 ZNF665 ATRNL1

1.28e-04171674972fab891135bd755d5526cbc5a963200067b0a6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 SGIP1 ZNF665 ATRNL1

1.28e-041716742a77ed79c6f2e700e789c80451a70ecb31639719
ToppCellEndothelial-B-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

EFEMP1 FBXL7 ZDHHC14 TM4SF18

1.31e-04172674d4e98ff9c7cbc95457e1d71fa60f151a2f178dae
ToppCellControl-Endothelial_cells-Systemic_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

FBXL7 THSD7A NR5A2 TM4SF18

1.31e-04172674c55dce1ed3ed7312394b4e050e1de852a994e130
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRC CENPF ZNF679 NOD2

1.31e-04172674ef33b5e0515c6d29fb6d9a673011c1b68ef264f3
ToppCell356C-Fibroblasts-Fibroblast-B_(Myofibroblast)|356C / Donor, Lineage, Cell class and subclass (all cells)

ATRNL1 LTBP1 BSN TMEFF2

1.34e-0417367475e26a65071b0d2f30ed0b2aa9859c488f5cf362
ToppCelldroplet-Liver-Npc-18m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRC MID1 LRP1 ADAM17

1.34e-041736749ba55e21d1037ec3150d77895e52f0b051df65da
ToppCell356C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|356C / Donor, Lineage, Cell class and subclass (all cells)

ATRNL1 LTBP1 BSN TMEFF2

1.34e-0417367426e2e674f5d312fa8f61c11b553dc6101f063b16
DrugScopolamine hydrochloride [55-16-3]; Down 200; 11.8uM; HL60; HT_HG-U133A

FBN2 FBXL7 ZFYVE9 TRPC5 ZDHHC14 ADAM17 C8A PML

9.38e-081986583018_DN
DrugAzathymine, 6 [932-53-6]; Up 200; 31.4uM; HL60; HT_HG-U133A

FBXL7 ZFYVE9 THSD7A ZDHHC14 LRP1 LTBP1 PML

1.49e-061976572466_UP
Drugtebuquine

KRT81 KRT83

8.03e-062652CID000071991
Drug3,5-di-O-galloylquinic acid

KRT81 KRT83

8.03e-062652CID000460896
Drugmelicopicine

KRT81 KRT83

8.03e-062652CID000101253
DrugPregnenolone [145-13-1]; Up 200; 12.6uM; MCF7; HT_HG-U133A

ZFYVE9 ZNF652 TRPC5 MID1 PRDM2 PML

1.56e-051876562856_UP
DrugATBI

KRT81 KRT83 KRT86

1.76e-0518653CID000505862
DrugPF-00539758-00 [351321-34-1]; Up 200; 10uM; PC3; HT_HG-U133A

CENPF ANKRD26 ZNF701 ADAM17 AKAP1 PML

1.87e-051936566421_UP
DrugOfloxacin [82419-36-1]; Up 200; 11uM; MCF7; HT_HG-U133A

THBS1 ZNF652 MID1 NR5A2 PRDM2 PML

1.98e-051956564696_UP
DrugRoxithromycin [80214-83-1]; Up 200; 4.8uM; MCF7; HT_HG-U133A

THBS1 ZFYVE9 CENPF KRT83 NR5A2 ZDHHC14

2.04e-051966563331_UP
DrugCinoxacin [28657-80-9]; Up 200; 15.2uM; MCF7; HT_HG-U133A

THBS1 FBXL7 ZFYVE9 ZDHHC14 PRDM2 PML

2.10e-051976563463_UP
DrugHarmaline hydrochloride dihydrate [6027-98-1]; Down 200; 14uM; PC3; HT_HG-U133A

XYLT2 CENPF ZNF652 ZDHHC14 LRP1 BICRAL

2.10e-051976566623_DN
DrugEpitiostanol [2363-58-8]; Down 200; 13uM; MCF7; HT_HG-U133A

XYLT2 ZNF665 ANKRD26 ADAM17 PRDM2 PML

2.10e-051976567342_DN
DrugAceclofenac [89796-99-6]; Up 200; 11.2uM; PC3; HT_HG-U133A

PHF3 ANKRD26 LYPD3 LTBP1 PRDM2 PML

2.10e-051976562117_UP
DrugSparteine (-) [90-39-1]; Down 200; 17uM; PC3; HT_HG-U133A

EFEMP1 FBXL7 ZNF701 BICRAL ADAM17 PML

2.16e-051986564568_DN
DrugEtofylline [519-37-9]; Down 200; 17.8uM; MCF7; HT_HG-U133A

PHF3 ZNF652 ANKRD26 ZNF701 PRDM2 PML

2.16e-051986562256_DN
Drugsulfonamide-3

KRT81 KRT83

2.40e-053652CID009847197
DrugAC1L1BIT

KRT81 KRT83 KRT86 GABRQ

2.62e-0560654CID000001457
DrugFAH2

KRT81 KRT83 TRPC5 TG

3.38e-0564654CID000000661
Drugpyriproxyfen

KRT81 KRT83 KRT86

3.78e-0523653CID000091753
DrugDabcyl

THBS1 ZFYVE9 ADAM17

4.31e-0524653CID000022650
DrugSalmfamide 1

FBN2 TG

4.80e-054652CID005487416
Druglactucin

KRT81 KRT83

4.80e-054652CID000442266
DrugLactupicrin

KRT81 KRT83

4.80e-054652CID000174880
DrugSuccimer

XYLT2 TET2 CERK THBS1 PTPRC PHF3 TRPC5 MID1 NR5A2 ZDHHC14 LRP1 ANKRD26 PRDM2

4.93e-0512646513ctd:D004113
Drugdictamnine

KRT81 KRT83

1.19e-046652CID000068085
Drugskimmianine

KRT81 KRT83

1.19e-046652CID000006760
Drugarborinine

KRT81 KRT83

1.19e-046652CID005281832
DrugTGQA

KRT81 KRT83

1.67e-047652CID000127406
Drug4-amino-2-trifluoromethyl-phenyl retinate

BECN1 PML

1.67e-047652ctd:C585745
DrugAnisomycin [22862-76-6]; Down 200; 15uM; PC3; HT_HG-U133A

XYLT2 CERK ZDHHC14 AKAP1 PML

1.96e-041876556764_DN
DrugLovastatin [75330-75-5]; Up 200; 9.8uM; MCF7; HT_HG-U133A

THBS1 ZFYVE9 ZNF652 PRDM2 NOD2

2.01e-041886552854_UP
DrugEthotoin [86-35-1]; Down 200; 19.6uM; PC3; HT_HG-U133A

THBS1 PHF3 ZNF665 ZNF652 LYPD3

2.01e-041886554545_DN
DrugDisulfiram [97-77-8]; Down 200; 13.4uM; PC3; HT_HG-U133A

CENPF PHF3 ZNF652 PALB2 PML

2.01e-041886552053_DN
DrugPhenformin hydrochloride [834-28-6]; Down 200; 16.6uM; PC3; HT_HG-U133A

XYLT2 PHF3 ZNF652 SCAF11 LTBP1

2.17e-041916554283_DN
DrugMethapyrilene hydrochloride [135-23-9]; Down 200; 13.4uM; PC3; HT_HG-U133A

XYLT2 THBS1 PHF3 LTBP1 PML

2.17e-041916556644_DN
DrugPronethalol hydrochloride [51-02-5]; Down 200; 15uM; MCF7; HT_HG-U133A

THBS1 PHF3 LTBP1 ADAM17 PRDM2

2.22e-041926554104_DN
DrugFenoprofen calcium salt dihydrate [53746-45-5]; Down 200; 7.2uM; PC3; HT_HG-U133A

THBS1 PHF3 ZNF652 BICRAL PRDM2

2.22e-041926554274_DN
DrugButacaine [149-16-6]; Down 200; 13uM; MCF7; HT_HG-U133A

XYLT2 ZFYVE9 PHF3 ZNF652 ADAM17

2.22e-041926553469_DN
DrugCotinine (-) [486-56-6]; Down 200; 22.6uM; PC3; HG-U133A

THBS1 EFEMP1 CENPF VPS13C SCAF11

2.22e-041926551929_DN
Drugtesmilifene

PTPRC LRP1

2.22e-048652ctd:C043062
Drugdesethylchloroquine

KRT81 KRT83

2.22e-048652CID000095478
DrugPivampicillin [33817-20-8]; Down 200; 8.6uM; PC3; HT_HG-U133A

THBS1 PHF3 ZNF665 ZNF652 PML

2.27e-041936555046_DN
Drugretinoic acid; Down 200; 1uM; MCF7; HT_HG-U133A

XYLT2 THBS1 PHF3 ANKRD26 LTBP1

2.27e-041936556931_DN
DrugMidodrine hydrochloride [3092-17-9]; Down 200; 13.8uM; PC3; HT_HG-U133A

ZFYVE9 PHF3 AKAP1 PRDM2 PML

2.33e-041946552087_DN
DrugMetformin hydrochloride [1115-70-4]; Down 200; 24.2uM; HL60; HT_HG-U133A

FBXL7 ZFYVE9 PHF3 ZNF652 PML

2.33e-041946551858_DN
DrugMethylprednisolone, 6-alpha [83-43-2]; Down 200; 10.6uM; PC3; HT_HG-U133A

PHF3 ZDHHC14 BICRAL MBIP PML

2.33e-041946557137_DN
DrugTetrandrine [518-34-3]; Down 200; 6.4uM; HL60; HT_HG-U133A

THBS1 FBXL7 NR5A2 PRDM2 PML

2.33e-041946552520_DN
DrugFusaric acid [536-69-6]; Up 200; 22.4uM; HL60; HT_HG-U133A

ZFYVE9 PHF3 ADAM17 AKAP1 PML

2.33e-041946551308_UP
DrugMethoxy-6-harmalan [3589-73-9]; Up 200; 18.6uM; MCF7; HT_HG-U133A

ZFYVE9 ZNF652 ANKRD26 AKAP1 PML

2.33e-041946552893_UP
Drugretinoic acid; Down 200; 1uM; MCF7; HT_HG-U133A

XYLT2 THBS1 EFEMP1 LTBP1 PRDM2

2.38e-041956556971_DN
Drugestradiol, USP; Up 200; 0.1uM; MCF7; HT_HG-U133A

THBS1 PHF3 VPS13C ADAM17 C8A

2.38e-041956555568_UP
DrugCytisine (-) [485-35-8]; Down 200; 21uM; PC3; HT_HG-U133A

FBXL7 CENPF ANKRD26 LYPD3 PML

2.38e-041956555739_DN
Drugtroglitazone; Down 200; 10uM; HL60; HT_HG-U133A

ZFYVE9 ZDHHC14 ANKRD26 BICRAL LTBP1

2.38e-041956556191_DN
Drug2-propylpentanoic acid; Up 200; 1000uM; MCF7; HT_HG-U133A

ZFYVE9 GABRQ RORA C8A TG

2.38e-041956555569_UP
DrugEburnamonine (-) [4880-88-0]; Up 200; 13.6uM; MCF7; HT_HG-U133A

FBXL7 ZFYVE9 CENPF PHF3 PML

2.44e-041966552781_UP
DrugNialamide [51-12-7]; Up 200; 13.4uM; MCF7; HT_HG-U133A

KRT83 MID1 RORA ZNF701 PML

2.44e-041966553871_UP
DrugCanrenoic acid potassium salt [2181-04-6]; Down 200; 10uM; PC3; HT_HG-U133A

ZNF665 SCAF11 BICRAL PRDM2 PML

2.44e-041966552065_DN
DrugNS-398; Up 200; 10uM; MCF7; HT_HG-U133A

VPS13C NR5A2 RORA ZNF701 PML

2.44e-041966556911_UP
Drugsulfite

THBS1 EFEMP1 LRP1 SESN3 LRP1B PRDM2 TMEFF2

2.47e-04438657CID000001099
DrugHydroxytacrine maleate (R,S) [118909-22-1]; Up 200; 12.2uM; MCF7; HT_HG-U133A

THBS1 FBXL7 CENPF GABRQ BICRAL

2.50e-041976554997_UP
DrugFoliosidine [2520-38-9]; Down 200; 13uM; MCF7; HT_HG-U133A

XYLT2 PHF3 MID1 ZDHHC14 PML

2.50e-041976554761_DN
DrugSuprofen [40828-46-4]; Down 200; 15.4uM; MCF7; HT_HG-U133A

FBXL7 KRT83 MID1 ANKRD26 PML

2.50e-041976554123_DN
Drugclozapine; Up 200; 10uM; MCF7; HT_HG-U133A

THBS1 ZFYVE9 ANKRD26 RORA ADAM17

2.50e-041976555589_UP
DrugCiprofibrate [52214-84-3]; Down 200; 13.8uM; HL60; HT_HG-U133A

XYLT2 FBXL7 MID1 ANKRD26 PML

2.50e-041976556138_DN
DrugTrimipramine maleate salt [521-78-8]; Down 200; 9.8uM; HL60; HT_HG-U133A

FBXL7 ZFYVE9 TRPC5 C8A PML

2.50e-041976553004_DN
DrugTenoxicam [59804-37-4]; Up 200; 11.8uM; MCF7; HT_HG-U133A

THBS1 CENPF PHF3 ZNF652 PRDM2

2.50e-041976552860_UP
DrugMemantine Hydrochloride [41100-52-1]; Down 200; 18.6uM; HL60; HT_HG-U133A

XYLT2 ZFYVE9 ZDHHC14 ANKRD26 BICRAL

2.50e-041976552934_DN
DrugNeomycin sulfate [1405-10-3]; Down 200; 4.2uM; PC3; HT_HG-U133A

ZFYVE9 ZNF665 LYPD3 AKAP1 PRDM2

2.50e-041976555867_DN
DrugAlfadolone acetate [23930-37-2]; Up 200; 10.2uM; MCF7; HT_HG-U133A

CENPF NR5A2 ANKRD26 PML NOD2

2.50e-041976556506_UP
DrugPNU-0293363 [326823-19-2]; Down 200; 10uM; PC3; HT_HG-U133A

XYLT2 ZFYVE9 PHF3 ZNF701 PML

2.56e-041986556568_DN
DrugGlafenine hydrochloride [65513-72-6]; Up 200; 9.8uM; MCF7; HT_HG-U133A

KRT83 ZNF701 ADAM17 PRDM2 PML

2.56e-041986557018_UP
Druggenistein; Up 200; 10uM; MCF7; HT_HG-U133A

THBS1 ZFYVE9 ADAM17 AKAP1 PML

2.56e-041986555595_UP
DrugBemegride [64-65-3]; Down 200; 25.8uM; HL60; HT_HG-U133A

XYLT2 FBXL7 PHF3 ZDHHC14 C8A

2.56e-041986553051_DN
DrugCotinine (-) [486-56-6]; Down 200; 22.6uM; MCF7; HT_HG-U133A

CENPF PHF3 ATRNL1 TRPC5 ZNF701

2.56e-041986555611_DN
DrugNizatidine [76963-41-2]; Up 200; 12uM; MCF7; HT_HG-U133A

FBXL7 CENPF PHF3 MID1 PML

2.56e-041986555406_UP
Drugpaclitaxel; Up 200; 0.1uM; MCF7; HG-U133A

XYLT2 ZNF652 ANKRD26 GABRQ PRDM2

2.56e-04198655640_UP
DrugIsoniazid [54-85-3]; Down 200; 29.2uM; MCF7; HT_HG-U133A

PHF3 ZDHHC14 ADAM17 PRDM2 PML

2.56e-041986552246_DN
DrugQuinethazone [73-49-4]; Down 200; 13.8uM; PC3; HT_HG-U133A

PHF3 LRP1 LYPD3 ADAM17 PRDM2

2.56e-041986553793_DN
DrugCefepime hydrochloride [123171-59-5]; Down 200; 7.4uM; MCF7; HT_HG-U133A

THBS1 CENPF ANKRD26 PRDM2 PML

2.56e-041986553581_DN
DrugDizocilpine maleate [77086-22-7]; Down 200; 11.8uM; PC3; HT_HG-U133A

XYLT2 ZFYVE9 PHF3 PRDM2 PML

2.56e-041986552069_DN
DrugBuspirone hydrochloride [33386-08-2]; Down 200; 9.4uM; PC3; HT_HG-U133A

THBS1 FBXL7 TRPC5 PRDM2 PML

2.62e-041996556743_DN
DrugTolbutamide [64-77-7]; Up 200; 14.8uM; MCF7; HT_HG-U133A

FBXL7 PHF3 RORA TG NOD2

2.62e-041996554362_UP
DrugDipyridamole [58-32-2]; Down 200; 8uM; MCF7; HT_HG-U133A

ZFYVE9 ATRNL1 TRPC5 ZNF701 PML

2.62e-041996555617_DN
Drug0198306-0000 [212631-61-3]; Up 200; 10uM; MCF7; HT_HG-U133A

CERK ZFYVE9 LTBP1 ADAM17 PML

2.62e-041996557099_UP
DrugMorantel tartrate [26155-31-7]; Up 200; 10.8uM; PC3; HT_HG-U133A

FBN2 ZDHHC14 ANKRD26 LYPD3 PML

2.62e-041996557250_UP
DrugProcaine hydrochloride [51-05-8]; Up 200; 14.6uM; PC3; HT_HG-U133A

THBS1 PTPRC PHF3 LYPD3 PML

2.68e-042006556329_UP
DrugUrosiol [128-13-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A

XYLT2 THBS1 ANKRD26 AKAP1 MBIP

2.68e-042006556484_DN
DrugNetilmicin sulfate [56931-57-2]; Up 200; 2.8uM; MCF7; HT_HG-U133A

MID1 ANKRD26 ADAM17 AKAP1 PML

2.68e-042006556005_UP
DrugFamprofazone [22881-35-2]; Up 200; 10.6uM; MCF7; HT_HG-U133A

FBN2 FBXL7 CENPF RORA AKAP1

2.68e-042006556029_UP
Drugbisdesethylchloroquine

KRT81 KRT83

2.85e-049652CID000122672
Drugadipamide

MID1 TG

2.85e-049652CID000012364
DrugMagnetite Nanoparticles

XYLT2 TET2 CERK THBS1 PTPRC PHF3 MID1 NR5A2 ZDHHC14 LRP1 ANKRD26 PRDM2

2.95e-0413106512ctd:D058185
DrugSFBs

THBS1 LTBP1

3.56e-0410652CID000131431
DiseaseBeaded hair

KRT81 KRT83 KRT86

1.02e-083653cv:C0546966
DiseaseMONILETHRIX

KRT81 KRT83 KRT86

1.02e-083653158000
Diseasemonilethrix (is_implicated_in)

KRT81 KRT83 KRT86

1.02e-083653DOID:0050472 (is_implicated_in)
DiseaseMonilethrix

KRT81 KRT83 KRT86

4.07e-084653C0546966
Diseasehair disease (is_implicated_in)

KRT81 KRT86

4.78e-062652DOID:421 (is_implicated_in)
Diseaseglaucoma

EFEMP1 THSD7A RORA LTBP1 LRP1B

2.33e-05154655MONDO_0005041
DiseaseProstatic Neoplasms

TET2 PTPRC CENPF SESN3 LRP1B PALB2 TMEFF2 PML

6.11e-05616658C0033578
DiseaseMalignant neoplasm of prostate

TET2 PTPRC CENPF SESN3 LRP1B PALB2 TMEFF2 PML

6.11e-05616658C0376358
Diseaseosteoarthritis

EFEMP1 ATRNL1 LTBP1 AKAP1 PRDM2

1.32e-04222655MONDO_0005178
DiseaseWNT1-inducible-signaling pathway protein 1 measurement

C8A TG

2.13e-0410652EFO_0008321
Diseaseadverse effect, response to xenobiotic stimulus

FBXL7 LRP1B TMEFF2

3.04e-0459653EFO_0009658, GO_0009410
Diseaseage at menarche

TET2 ATRNL1 RORA BSN LRP1B PRDM2 PML

3.28e-04594657EFO_0004703
DiseaseMigraine Disorders

LRP1 GABRQ

3.67e-0413652C0149931
Diseasebody weight

TET2 FBN2 EFEMP1 PHF3 VPS13C HDX RORA LTBP1 LRP1B TMEFF2

4.13e-0412616510EFO_0004338
Diseasecalcium measurement

TET2 FBN2 SHOC1 LYPD3 RORA AKAP1 LRP1B

4.57e-04628657EFO_0004838
Diseaseepilepsy (implicated_via_orthology)

KCNA1 LRP1 BSN LRP1B

4.67e-04163654DOID:1826 (implicated_via_orthology)
Diseasehepatocellular carcinoma (is_marker_for)

TET2 KDM3A EFEMP1 LRP1B PML

5.35e-04301655DOID:684 (is_marker_for)
Diseasehousehold income

TET2 SGIP1 THSD7A BSN LRP1B

5.60e-04304655EFO_0009695
Diseaseuterine prolapse

FBN2 EFEMP1

5.62e-0416652EFO_1001864
Diseaseserum iron measurement

ZDHHC14 RORA LRP1B

9.16e-0486653EFO_0006332
Diseaseage of onset of childhood onset asthma

ZNF652 RORA NOD2

1.11e-0392653OBA_2001015
Diseaseinsular cortex volume measurement

THSD7A VPS13C

1.17e-0323652EFO_0010309
Diseasediffusing capacity of the lung for carbon monoxide

KRT86 ZDHHC14 LRP1B

1.26e-0396653EFO_0009369
Diseasetemperament and character inventory

FBN2 TG

1.28e-0324652EFO_0004825
Diseaseasthma

PTPRC ZNF665 ZNF652 LRP1 RORA LRP1B NOD2

1.30e-03751657MONDO_0004979
DiseasePancreatic Neoplasm

EFEMP1 NR5A2 PALB2

1.42e-03100653C0030297
DiseaseFEV/FEC ratio

TET2 EFEMP1 VPS13C SLMAP LRP1 LTBP1 MBIP PML TG

1.43e-031228659EFO_0004713
Diseaselean body mass

TET2 EFEMP1 VPS13C LTBP1 PML

1.50e-03379655EFO_0004995
DiseaseMalignant neoplasm of pancreas

EFEMP1 NR5A2 PALB2

1.50e-03102653C0346647
Diseaseneuroticism measurement, cognitive function measurement

TET2 THSD7A RORA LRP1B TMEFF2 TG

1.54e-03566656EFO_0007660, EFO_0008354
Diseaselower face morphology measurement

RORA LTBP1 LRP1B

1.81e-03109653EFO_0010948
Diseasebirth weight

TET2 CENPF RORA ADAM17 PML

1.87e-03399655EFO_0004344
DiseaseHuntington disease, disease progression measurement

ST8SIA6 ATRNL1

2.00e-0330652EFO_0008336, MONDO_0007739

Protein segments in the cluster

PeptideGeneStartEntry
CQASQLQGQKEESCV

AKAP1

376

Q92667
VRQAQCGQDFQCKET

C8A

91

P07357
DRKCQLNVCDNENRT

ANKRD26

101

Q9UPS8
TFQDQIECNCLKRNE

LRRC9

1431

Q6ZRR7
ANCTTANQNCVNKSK

KCNA1

476

Q09470
QSKNCFQLILQCAQE

HDX

26

Q7Z353
KCVCDQNFQERNNTC

LRP1B

3866

Q9NZR2
QQVVTSSQQQQCCQK

KRT39

296

Q6A163
KAKEQIRNCENNCQQ

LMOD3

176

Q0VAK6
IRNCENNCQQVTDKA

LMOD3

181

Q0VAK6
NLFNCKNCANEAVVQ

GABRQ

46

Q9UN88
EAQFECQNHRCISKQ

LRP1

2736

Q07954
NNSKRRCKVNCETDQ

LINC02872

106

A2RU37
TKLQFYQNRECCQSN

KRT86

136

O43790
NFNTCTQCHNKVCNQ

BSN

186

Q9UPA5
QLNVTENECQNYKRC

BECN1

151

Q14457
NTFCQDINECQLQGV

LTBP1

621

Q14766
QQCAQDRCNAKLNLT

LYPD3

106

O95274
FTFKENQLCRNTCQE

PALB2

816

Q86YC2
SCKNAQLARDFQQCS

FAM189B

116

P81408
VDNESCCSRSNNKIQ

KDM3A

491

Q9Y4C1
TQQQFFCQAQKKCLN

BICRAL

606

Q6AI39
CRAEQAFQASQIKEN

CENPF

461

P49454
ANCFDLQTLNVQDCE

FBXL7

451

Q9UJT9
CFVCRQSKQQLEEEQ

CERK

351

Q8TCT0
EKENNRCNDQCNQFT

CCDC66

671

A2RUB6
RCNDQCNQFTRIEKQ

CCDC66

676

A2RUB6
TCINNNVCEQCKNLT

ATRNL1

1021

Q5VV63
ENNVREFCNVIDCNQ

MBIP

176

Q9NS73
CQTKQHNCQFLCVNT

FBN2

2536

P35556
NQSANCLKSCNEQIE

SCAF11

441

Q99590
TKLQFYQNRECCQSN

KRT83

141

P78385
VQETFNKNFVCNVCE

PRDM2

1126

Q13029
NNKRYTCIENQNCQI

NR5A2

116

O00482
TCIENQNCQIDKTQR

NR5A2

121

O00482
NECDASNQCAQQCYN

EFEMP1

256

Q12805
QAERPNNQQNCFKVC

THSD7A

101

Q9UPZ6
QNECYLRQAACKQQS

TMEFF2

111

Q9UIK5
EFQFLRCQQCQAEAK

PML

51

P29590
CLEKCSALQNQNQDL

SHOC1

71

Q5VXU9
SCCDAVQNFVVSQNN

ST8SIA6

131

P61647
AQECFQERSNKVCGN

ADAM17

466

P78536
CNQCGKVFTQNSNLA

ZNF665

656

Q9H7R5
NCEECDNTFNQSSNL

ZNF431

541

Q8TF32
CVGDVTENQICNKQD

THBS1

531

P07996
CEMCSQEAFQAQRSQ

NOD2

26

Q9HC29
ENNNNYKCCQSENCS

TM4SF18

71

Q96CE8
QQSNATYSCPRQKNC

RORA

101

P35398
LCCDNTQNDANTKEF

SGIP1

631

Q9BQI5
NFCVCDLANDNNIEN

SESN3

231

P58005
SFQLRCQQCEDQQRE

SLMAP

636

Q14BN4
CNEVNQCLSTTQNKI

ZNF679

141

Q8IYX0
AQQIANCKQCIERSA

MID1

296

O15344
CNECGKVFSQNSNLQ

ZNF534

481

Q76KX8
LCSAEKNSCVQQSDN

PHF3

1701

Q92576
NAFCVIVCNEKNNIA

VPS13C

1091

Q709C8
NAFNVFVCDQKCNIA

VPS13C

1606

Q709C8
TATNQQNKRNQCSCN

ROS1

1316

P08922
QNKRNQCSCNVTEFE

ROS1

1321

P08922
QSQSDMCDQDQCIQS

ZDHHC14

351

Q8IZN3
ECNQVEKSFNNNSSV

ZNF347

206

Q96SE7
QDNQEECFKQVIRTC

ZNF790

131

Q6PG37
NNCKGIRCEKQNNAF

TRPC5

551

Q9UL62
QERSLECNKFAENCN

ZNF713

176

Q8N859
ECNKFAENCNLNSNL

ZNF713

181

Q8N859
CNECGKVFNQQSNLA

ZNF701

366

Q9NV72
QQTDCEKNIQCVSCN

ZNF652

291

Q9Y2D9
CNECDKAFNQQSNLA

ZNF600

276

Q6ZNG1
KCNECGKAFNQQSQL

ZNF600

611

Q6ZNG1
RCFQEQEQKSQQASV

TET2

881

Q6N021
KLNVNENVECGNNTC

PTPRC

251

P08575
QCAEDGSFQTVQCQN

TG

51

P01266
ASTKQCQQEIANVVC

XYLT2

176

Q9H1B5
NCDKRTLQNDLQDCN

ZFYVE9

156

O95405
QDSQECCRQAVQGRQ

nan

76

Q6ZVH6
TKLQFYQNRECCQSN

KRT81

136

Q14533